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https://www.readbyqxmd.com/read/28301790/human-papillomavirus-vaccination-and-genital-warts-in-young-indigenous-australians-national-sentinel-surveillance-data
#1
Hammad Ali, Hamish McManus, Catherine C O'Connor, Denton Callander, Marlene Kong, Simon Graham, Dina Saulo, Christopher K Fairley, David G Regan, Andrew Grulich, Nicola Low, Rebecca J Guy, Basil Donovan
OBJECTIVES: To examine the impact of the national human papillomavirus (HPV) vaccination program (available to girls and women [12-26 years] since 2007 and to boys [12-15 years] since 2013) on the number of diagnoses of genital warts in Australian Aboriginal and Torres Strait Islander (Indigenous) people. DESIGN, SETTING, PARTICIPANTS: Analysis of routinely collected data from patients attending 39 sexual health clinics (SHCs) in the Genital Warts Surveillance Network for the first time...
March 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28277236/-we-ve-been-together-we-don-t-have-it-we-re-fine-how-relationship-status-impacts-human-papillomavirus-vaccine-behavior-among-young-adult-women
#2
Erika L Thompson, Cheryl A Vamos, Diane M Straub, William M Sappenfield, Ellen M Daley
BACKGROUND: Vaccination against the human papillomavirus (HPV) has the potential to significantly reduce morbidity and mortality associated with genital warts and HPV-related cancers. However, HPV vaccination rates continue to be suboptimal among the "catch-up" population of 18- to 26-year-old women. One consistent risk factor for nonvaccination is being in a relationship. This study aimed to understand how relationship status and vaccination status impact risk perceptions and perceived need for the HPV vaccine among young adult women...
October 27, 2016: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28274028/ano-genital-warts-and-hiv-status-a-clinical-study
#3
Shashikant Balakrishana Dhumale, Shimpa Sharma, Arvind Gulbake
INTRODUCTION: Ano-Genital Warts (AGW) like other Sexually Transmitted Diseases (STD) is associated with Human Immunodeficiency Virus (HIV) infection. This study of AGW was done in HIV positive and HIV negative patients. AIM: To study the risk factors and clinical presentations of ano-genital warts in HIV positive and negative patients. MATERIALS AND METHODS: A comparative, cross-sectional, descriptive study of 25 HIV positive and 25 HIV negative (n=50) AGW patients between 15-60 years of both sex was conducted in Dr...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28267627/stop-codon-mutagenesis-for-homogenous-expression-of-human-papillomavirus-l1-protein-in-escherichia-coli
#4
Daning Wang, Fei Fan, Zhihai Li, Xinlin Liu, Shuo Song, Shuangping Wei, Maozhou He, Yahua Lin, Zhongyi Li, Minxi Wei, Hai Yu, Ying Gu, Shaowei Li, Ningshao Xia
Human papillomavirus (HPV) is widely accepted to be the major causative pathogen of cervical cancer, warts, and other epithelial tumors. Virus infection and subsequent disease development can be prevented by vaccination with HPV vaccines derived from eukaryotic expression systems. Here, we report the soluble expression of the major capsid protein L1 of HPV31, a dominant carcinogenic HPV genotype, in Escherichia coli. HPV31 L1 protein and its elongated form (L1+) were observed in SDS-PAGE and CE-SDS analysis, generated by the native HPV31 L1 gene with a TAA stop codon...
March 3, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28261849/the-presence-of-human-papillomavirus-in-semen-does-not-affect-the-integrity-of-sperm-dna
#5
E I Cortés-Gutiérrez, M I Dávila-Rodríguez, J L Fernández, L O de la O-Pérez, M E Garza-Flores, R Eguren-Garza, J Gosálvez
It remains unknown whether human papillomaviruses (HPVs) in semen affect sperm DNA integrity. We investigated whether the presence of these viruses in semen was associated with an elevated sperm DNA fragmentation index. Semen samples of 22 normozoospermic patients undergoing infertility treatment, nine fertile donors and seven fertile men with a risk of HPV infection (genital warts or condylomas) were included in the study. The samples were examined by an INNO-LiPA test PCR-based reverse hybridisation array that identifies 28 types of HPVs as simple or multiple infections...
March 6, 2017: Andrologia
https://www.readbyqxmd.com/read/28253203/beta-human-papillomavirus-infection-is-prevalent-in-elephantiasis-and-exhibits-a-productive-phenotype-a-case-control-study
#6
John Andrew Carlson, Peter Rady, Pooja Kadam, Qin He, Rebecca Simonette, Stephen Tyring
Elephantiasis is considered a cutaneous region of immune deficiency with cobblestone-like surface caused by a wart-like eruption. Verrucosis is a diffuse human papillomavirus (HPV) infection linked to immunodeficiency disorders. The objective of this study was to examine the prevalence of HPV infection in lymphedema and its pathogenic role in elephantiasis. A retrospective case-control study was performed examining lymphedematous skin and controls of peritumoral normal skin. HPV infection was evaluated at the DNA, protein, and histopathologic levels by polymerase chain reaction, immunohistochemistry, and light microscopy, respectively...
February 3, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28248020/-anogenital-warts-a-new-way-of-solving-the-common-problem-of-urology-results-of-long-term-follow-up
#7
A D Protasov, I S Lipatov, M P Kostinov, Yu V Tezikov, A D Shmitko, D V Pakhomov, D A Blagovidov, A V Zhestkov, A A Ryzhov, E V Vekhova
AIM: To evaluate the effectiveness of combined use of the imiquimod 5% cream and vaccination against human papillomavirus (HPV) using a quadrivalent recombinant vaccine to achieve long-term clinical remission of chronic HPV infection manifested by anogenital warts. MATERIAL AND METHODS: The study comprised 36 patients, including 22 men, aged 26.4+/-4.1 years, who had from 1 to 5 anogenital warts. Participants of the study were vaccinated by quadrivalent recombinant vaccine under a 3-dose scheme 0-2-6 months co-administered with imiquimod 5% cream three times per week up to 16 weeks...
November 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28238336/human-papilloma-virus-dermatosis-in-human-immunodeficiency-virus-positive-patients-a-14-year-retrospective-study-in-965-patients
#8
Almudena Nuno-Gonzalez, Juan Emilio Losa Garcia, José Luis López Estebaranz, María Dolores Martin-Rios
INTRODUCTION: The incidence of the human papilloma virus (HPV) has not dropped in HIV-positive patients despite the discovery of antiretroviral therapy (ART). Our goal is to assess the prevalence of HPV in HIV patients and its relationship with the epidemiological and virological characteristics of HIV patients. PATIENTS AND METHODS: Retrospective cohort of 965 patients diagnosed with HIV from 1998 to 2012. We analyzed patients' demographic factors and factors related to the HPV...
February 18, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28236614/treatment-of-athlete-s-plantar-warts-using-a-botanical-blend-a-case-report
#9
Erik O Nelson, Adam F Kozin, Guillermo Ruiz, Arben Lasku, Jeffrey O Langland
Context • Viral plantar warts, or verruca plantaris, are a benign epithelial tumor caused by various strains of the human papilloma virus (HPV). Current treatments have had mixed degrees of success, are moderately invasive, and are often incompatible with participation in sports. Objective • The study intended to examine the benefits of treating plantar warts with a topical, botanical blend that has had clinical success treating herpes simplex virus cold sores. Methods • A synergistic botanical blend was applied topically...
February 27, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28213874/disease-burden-of-human-papillomavirus-infection-in-the-netherlands-1989-2014-the-gap-between-females-and-males-is-diminishing
#10
Scott A McDonald, Venetia Qendri, Johannes Berkhof, Hester E de Melker, Johannes A Bogaards
PURPOSE: Besides cervical cancer, HPV infection is linked to a multitude of diseases in both males and females, suggesting that vaccination programmes should be re-evaluated, with a judicious assessment made of the disease burden stratified by sex, age, and genotype. Projections of burden into the near future are also needed to provide a benchmark for evaluating the impact of vaccination programmes, and to assess the need for scaling-up preventive measures. METHODS: Using the disability-adjusted life-years (DALY) measure, we estimated the total HPV-associated disease burden in the Netherlands...
March 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28191723/perceptions-of-hpv-and-attitudes-towards-hpv-vaccination-amongst-men-who-have-sex-with-men-a-qualitative-analysis
#11
Tom Nadarzynski, Helen Smith, Daniel Richardson, Alex Pollard, Carrie Llewellyn
OBJECTIVES: Men who have sex with men (MSM) are at risk of genital warts and anal cancer due to human papillomavirus (HPV) infection. This study explores MSMs' perceptions of HPV and HPV vaccination prior to the introduction of this programme. DESIGN: Focus groups and one-to-one interviews with self-identified MSM were conducted between November 2014 and March 2015 in Brighton, UK. METHODS: Participants were recruited from community-based lesbian-gay-bisexual-transgender (LGBT) venues and organizations...
February 13, 2017: British Journal of Health Psychology
https://www.readbyqxmd.com/read/28166736/prevalence-and-incidence-of-external-genital-warts-in-a-sample-of-italian-general-female-population
#12
Barbara Suligoi, Giorgio Vittori, Maria Cristina Salfa, Laura Timelli, Dario Corsini, Giovanni Fattorini, Luciano Mariani
BACKGROUND: The Human papillomavirus is the most common sexually transmitted virus worldwide. The objective of this study was to estimate: 1) the prevalence and the incidence of external genital warts (eGW) in a sample of women attending community outpatient clinics and 2) the total number of eGW cases in the Italian female population aged 15-64 years. METHODS: A prospective study was performed for a 12-month period between 2009 and 2010, among a sample of women attending community gynecological outpatient clinics located throughout Italy...
February 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28160045/-genital-warts-in-hiv-infected-individuals
#13
REVIEW
U Wieland, A Kreuter
Anogenital warts (condylomata acuminata) are much more frequent in human immunodeficiency (HIV)-positive patients compared to HIV-negative individuals. Anogenital warts of HIV-infected patients differ from those of HIV-negative individuals with respect to their spread, occurrence on more unusual anatomical sites, human papillomavirus (HPV)-type spectrum, tendency to recur, and risk of malignant transformation. Between 18 and 56% of anogenital warts of HIV-positive patients harbor high-grade dysplasia. Therefore, anogenital warts of HIV-infected patients should be preferentially treated with ablative methods and should be evaluated histopathologically...
March 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28148228/health-economic-evaluation-of-human-papillomavirus-vaccines-in-women-from-venezuela-by-a-lifetime-markov-cohort-model
#14
Ariel Esteban Bardach, Osvaldo Ulises Garay, María Calderón, Andrés Pichón-Riviére, Federico Augustovski, Sebastián García Martí, Paula Cortiñas, Marino Gonzalez, Laura T Naranjo, Jorge Alberto Gomez, Joaquín Enzo Caporale
BACKGROUND: Cervical cancer (CC) and genital warts (GW) are a significant public health issue in Venezuela. Our objective was to assess the cost-effectiveness of the two available vaccines, bivalent and quadrivalent, against Human Papillomavirus (HPV) in Venezuelan girls in order to inform decision-makers. METHODS: A previously published Markov cohort model, informed by the best available evidence, was adapted to the Venezuelan context to evaluate the effects of vaccination on health and healthcare costs from the perspective of the healthcare payer in an 11-year-old girls cohort of 264,489...
February 2, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28132413/immunotolerant-indoleamine-2-3-dioxygenase-increases-in-condyloma-acuminata
#15
Z Xie, M Zhang, W Xiong, H Y Wan, X C Zhao, T Xie, H Lei, Z C Lin, D S Luo, X L Liang, Y H Chen
BACKGROUND: The tryptophan-depleting enzyme indoleamine-2,3-dioxygenase (IDO) is critical for the regulation of immune tolerance and plays an important role in immune-associated skin diseases. OBJECTIVES: To analyze the level of IDO in condyloma acuminata (CA) and its role in this condition. METHODS: IDO expression was assessed in the skin and peripheral blood of healthy subjects and patients with CA. To assess the role of skin IDO in immunity, the ability of isolated epidermal cells to metabolize tryptophan and the influence on polyclonal T cell mitogen (PHA)-stimulated T cell proliferation were explored...
January 29, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28131060/proteomic-comparison-of-chelidonium-majus-l-latex-in-different-phases-of-plant-development
#16
Robert Nawrot, Rico Lippmann, Andrea Matros, Oskar Musidlak, Grzegorz Nowicki, Hans-Peter Mock
Chelidonium majus L. (Papaveraceae) latex is used in traditinonal folk medicine to treat papillae, warts, condylomas, which are visible effects of human papilloma virus (HPV) infections. The aim of this work was to provide new insights into the biology and medicinal use of C. majus milky sap in the flowering and fruit ripening period of the plant by comparing the protein content between samples collected on respective developmental stages using LC-MS-based label-free proteome approach. For quantification, the multiplexed LC-MS data were processed using comparative chemometric approach...
January 13, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28126492/no-evidence-for-cross-protection-of-the-hpv-16-18-vaccine-against-hpv-6-11-positivity-in-female-sti-clinic-visitors
#17
Petra J Woestenberg, Audrey J King, Marianne A B van der Sande, Robine Donken, Suzan Leussink, Fiona R M van der Klis, Christian J P A Hoebe, Johannes A Bogaards, Birgit H B van Benthem
OBJECTIVES: Data from a vaccine trial and from post-vaccine surveillance in the United Kingdom have suggested that the bivalent HPV-16/18 vaccine offers cross-protection against HPV-6/11 and protection against anogenital warts (AGW). We studied the effect of the bivalent vaccine on genital HPV-6/11 positivity and AGW in the Netherlands. METHODS: We included all vaccine-eligible women from the PASSYON study, a biennial cross-sectional study among 16- to 24-year-old sexually transmitted infection (STI) clinic attendants...
January 23, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28121292/ranpirnase-eradicates-human-papillomavirus-in-cultured-cells-and-heals-anogenital-warts-in-a-phase-i-study
#18
Luis Squiquera, Debra J Taxman, Sarah A Brendle, Roberto Torres, Jamie Sulley, Thomas Hodge, Neil Christensen, David Sidransky
BACKGROUND: Human papillomaviruses (HPV), the causative agent of anogenital warts, are the most prevalent sexually transmitted infectious agents, and wart treatment poses a persistent challenge. We assessed the safety and efficacy of treating HPV with ranpirnase, an endoribonuclease from the Northern Leopard frog that has been used extensively in Phase III oncology trials. METHODS: As initial verification of ranpirnase antiviral activity, we assessed its ability to eliminate papillomaviruses in cultured cells...
January 25, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28107544/cutaneous-hpv8-and-mmupv1-e6-proteins-target-the-notch-and-tgf-%C3%AE-tumor-suppressors-to-inhibit-differentiation-and-sustain-keratinocyte-proliferation
#19
Jordan M Meyers, Aayushi Uberoi, Miranda Grace, Paul F Lambert, Karl Munger
Cutaneous beta-papillomaviruses are associated with non-melanoma skin cancers that arise in patients who suffer from a rare genetic disorder, Epidermodysplasia verruciformis (EV) or after immunosuppression following organ transplantation. Recent studies have shown that the E6 proteins of the cancer associated beta human papillomavirus (HPV) 5 and HPV8 inhibit NOTCH and TGF-β signaling. However, it is unclear whether disruption of these pathways may contribute to cutaneous HPV pathogenesis and carcinogenesis...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28070898/clearance-of-recalcitrant-warts-in-a-patient-with-idiopathic-immune-deficiency-following-administration-of-the-quadrivalent-human-papillomavirus-vaccine
#20
S P Smith, H E Baxendale, J C Sterling
Human papillomavirus (HPV)-induced cutaneous warts are potentially serious and debilitating. In immunosuppressed patients, these warts may be resistant to standard therapies. We report a case of a young patient with a primary immune deficiency whose recalcitrant cutaneous warts regressed completely following administration of a quadrivalent HPV vaccine.
January 10, 2017: Clinical and Experimental Dermatology
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