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https://www.readbyqxmd.com/read/29770079/summary-of-the-naci-update-on-the-recommended-use-of-human-papillomavirus-hpv-vaccine-nine-valent-hpv-vaccine-two-dose-immunization-schedule-and-the-use-of-hpv-vaccines-in-immunocompromised-populations
#1
S L Deeks, M C Tunis, S Ismail
Background: Human papillomavirus (HPV) infections are the most common sexually transmitted infections. In the absence of vaccination, it is estimated that 75% of sexually active Canadians will have an HPV infection at some point in their lives. HPV vaccine programs were first recommended by Canada's National Advisory Committee on Immunization (NACI) in 2007. In addition to the existing HPV vaccine options in Canada, NACI recently recommended the use of a newly authorized nine-valent HPV (HPV9) vaccine according to a 3-dose immunization schedule for the prevention of HPV types 6-, 11-, 16-, 18-, 31-, 33-, 45-, 52- and 58-related cancers and anogenital warts in females aged 9 to 45 years and males aged 9 to 26 years...
June 1, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29762430/the-impact-of-varying-numbers-of-quadrivalent-human-papillomavirus-vaccine-doses-on-anogenital-warts-in-the-united-states-a-database-study
#2
Burak Zeybek, Yu-Li Lin, Yong-Fang Kuo, Ana M Rodriguez
OBJECTIVE: The aim of the study was to investigate the effects of 3 or less quadrivalent human papillomavirus (HPV) vaccine doses on anogenital warts in both males and females in the United States. MATERIALS AND METHODS: We conducted a retrospective database study that included males and females aged 9 to 26 years who received varying numbers of vaccine doses between 2006 and 2015. The primary outcome was the incidence of anogenital warts starting 3 months after the last dose of the HPV vaccine...
May 8, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29750774/genital-wart-and-human-papillomavirus-prevalence-in-men-in-the-united-states-from-penile-swabs-results-from-national-health-and-nutrition-examination-surveys
#3
Michael Daugherty, Timothy Byler
INTRODUCTION: Human papillomavirus (HPV) is a common sexually transmitted infection in the United States that can lead to both malignant (high-risk) and benign (low-risk) findings. These low-risk findings include both genital condyloma, anal warts, and adult or juvenile papillomatosis, which are directly attributable to subtypes HPV 6 and HPV 11. We aim to estimate the prevalence of genital wart infections in men in the US population using a nationwide sample. METHODS: The NHANES database was queried for all men aged 18 to 59 years during the years 2013 to 2014...
June 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29744768/symptom-based-versus-laboratory-based-diagnosis-of-five-sexually-transmitted-infections-in-female-sex-workers-in-iran
#4
Armita Shahesmaeili, Mohammad Karamouzian, Mostafa Shokoohi, Kianoush Kamali, Noushin Fahimfar, Seyed Alireza Nadji, Hamid Sharifi, Ali Akbar Haghdoost, Ali Mirzazadeh
Among 1337 Iranian adult female sex workers in 2015, we assessed the diagnostic value of 4 self-reported sexually transmitted infection (STIs) symptoms for detecting laboratory-confirmed gonorrhea, chlamydia, trichomoniasis, human papillomavirus (HPV), and syphilis. While 37.7% reported vaginal discharge (VD), 25.9% reported pain or burning (P/B), 3.0% reported genital ulcers (GU), and 1.4% reported genital warts (GW), the prevalence of laboratory-confirmed syphilis, gonorrhea, chlamydia, trichomoniasis, and HPV was 0...
May 9, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29743937/epidemiologic-and-economic-burden-of-hpv-diseases-in-spain-implication-of-additional-5-types-from-the-9-valent-vaccine
#5
Noelia López, Aureli Torné, Agustín Franco, María San-Martin, Elisabet Viayna, Carmen Barrull, Nuria Perulero
Background: A new nonavalent human papillomavirus (HPV) vaccine that includes genotypes 6/11/16/18/31/33/45/52/58 has been recently approved in Spain. A previous study has shown that attributable fraction of HPV related diseases in Spain is consistent with that reported in European and global studies. The aim of the present study was to estimate the annual direct costs associated to the following HPV-related diseases: genital warts, high grade precancerous lesions and cancer of cervix, vulva, vagina, anus and penis and head and neck cancer, caused by genotypes included in the nonavalent (9vHPV) and quadrivalent vaccines (4vHPV), in Spanish men and women...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29743371/roles-of-fc-domain-and-exudation-in-l2-antibody-mediated-protection-against-human-papillomavirus
#6
Joshua W Wang, Wai Hong Wu, Tsui-Chin Huang, Margaret Wong, Kihyuck Kwak, Keiko Ozato, Chien-Fu Hung, Richard B S Roden
To address how L2-specific antibodies prevent human papillomavirus (HPV) infection of the genital tract we generated neutralizing monoclonal antibodies (MAbs) WW1, a rat IgG2a that binds L2 residues 17-36 (like mouse MAb RG1), and JWW3, a mouse IgG1 derivative of Mab24 specific to L2 residues 58-64. By Western blot, WW1 recognized L2 of 29/34 HPV genotypes tested, compared to only 13/34 for RG1, and 25/34 for JWW3. WW1 IgG and (Fab')2 bound HPV16 pseudovirions similarly, however whole IgG provided better protection against HPV vaginal challenge...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29717924/prevalence-and-burden-related-to-genital-warts-in-india
#7
Uday S Khopkar, Murlidhar Rajagopalan, Anahita R Chauhan, Smita Kothari-Talwar, Puneet K Singhal, Karen Yee, Amit Kulkarni, Nuria Lara, Montserrat Roset, Anna R Giuliano, Suzanne M Garland
The prevalence of genital warts (GW) and self-reported human papillomavirus (HPV) as well as disease-related psychosocial impact among male and female patients aged 18-60 years in India were assessed. GW prevalence was estimated using a 2-week daily log of patients examined from June 7-September 22, 2011 by 200 participating physicians in 6 regions of India. Psychosocial impact was estimated using one-time, self-administered surveys, including HPV Impact Profile (HIP), Cuestionario Específico para Condiloma Acuminado ([Spanish] CECA; "Specific questionnaire for Condylomata Acuminata") and EuroQol-5 Dimension survey...
May 2, 2018: Viral Immunology
https://www.readbyqxmd.com/read/29715305/prevalence-incidence-and-correlates-of-low-risk-hpv-infection-and-anogenital-warts-in-a-cohort-of-women-living-with-hiv-in-burkina-faso-and-south-africa
#8
Admire Chikandiwa, Helen Kelly, Bernard Sawadogo, Jean Ngou, Pedro T Pisa, Lorna Gibson, Marie-Noelle Didelot, Nicolas Meda, Helen A Weiss, Michel Segondy, Philippe Mayaud, Sinead Delany-Moretlwe
OBJECTIVE: To report the prevalence and incidence of low-risk human papillomavirus infection (LR-HPV) and anogenital warts (AGW) among women living with HIV (WLHIV) in Burkina Faso (BF) and South Africa (SA), and to explore HIV-related factors associated with these outcomes. METHODS: We enrolled 1238 WLHIV (BF = 615; SA = 623) aged 25-50 years and followed them at three time points (6, 12 and 16 months) after enrolment. Presence of AGW was assessed during gynaecological examination...
2018: PloS One
https://www.readbyqxmd.com/read/29715059/human-papillomavirus-vaccination-and-the-role-of-herd-effects-in-future-cancer-control-planning-a-review
#9
Talía Malagón, Cassandra Laurie, Eduardo L Franco
Vaccine herd effects are the indirect protection that vaccinated persons provide to those who remain susceptible to infection, due to the reduced transmission of infections. Herd effects have been an important part of the discourse on how to best implement human papillomavirus (HPV) vaccines and prevent HPV-related diseases. Areas covered: In this paper, we review the theory of HPV vaccine herd effects derived from mathematical models, give an account of observed HPV vaccine herd effects worldwide, and examine the implications of vaccine herd effects for future cervical cancer screening efforts...
May 1, 2018: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29705733/novel-management-of-vaginal-chronic-graft-versus-host-disease-causing-haematometra-and-haematocolpos
#10
Alice Buchan, Melissa A Merideth, Richard W Childs, Pamela Stratton
Genital chronic graft-versus-host disease (GVHD) in women posthaematopoietic cell transplantation may cause vaginal mucosal sclerosis. Human papillomavirus (HPV) reactivation, also common post-transplantation, limits local immunosuppressive, but not oestrogen treatment. A 36-year-old nulliparous woman developed coincidental genital chronic GVHD and HPV 22 months after transplant for aplastic anaemia. Topical immunosuppression for GVHD led to an eruption of warts successfully treated with laser surgery and cone biopsy...
April 28, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29693347/comparative-cost-effectiveness-analysis-of-two-different-two-dose-human-papillomavirus-vaccines-in-malaysia
#11
Georges Van Kriekinge, Woo-Yun Sohn, Syed Mohamed Aljunid, Ruey Soon, Chee-Meng Yong, Jing Chen, I-Heng Lee
Purpose: To comparatively evaluate the results of a 2-dose human papillomavirus (HPV) vaccination programme with the AS04-adjuvanted HPV16/18 vaccine (AS04-HPV-16/18v) or HPV-6/11/16/18 vaccine (4vHPVv), in addition to cervical cancer (CC) screening, in Malaysia. Methods: A lifetime Markov model replicating the natural history of HPV in 13-year-old girls was adapted to Malaysia to assess the impact of vaccination on pre-cancerous lesions, genital warts and CC cases, CC deaths, quality-adjusted life years (QALYs), and costs from the perspective of the Malaysian Ministry of Health...
April 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29687566/intralesional-bleomycin-injection-vs-microneedling-assisted-topical-bleomycin-spraying-in-treatment-of-plantar-warts
#12
Mohamed R Al-Naggar, Ahmad S Al-Adl, Ali R Rabie, Mahmoud R Abdelkhalk, Mohamed L Elsaie
BACKGROUND: Warts, or verrucae, are benign epithelial profilerations of skin and mucosa caused by infection with HPV and poses a challenge to treat. OBJECTIVE: To compare between single and microneedling-assisted multipuncture techniques of intralesional application in treatment of plantar warts. METHODS: The study included 60 Patients who were divided into two groups (A&B). Each group consisted of (30) patients. Group (A) subjects received intralesional bleomycin with a single injection using syringe needle...
April 23, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29653131/bet-bromodomain-inhibitors-show-anti-papillomavirus-activity-in-vitro-and-block-crpv-wart-growth-in-vivo
#13
Mary A Morse, Karla K Balogh, Sarah A Brendle, Colin A Campbell, Mao X Chen, Rebecca C Furze, Isobel L Harada, Ian D Holyer, Umesh Kumar, Kevin Lee, Rab K Prinjha, Martin Rüdiger, Jon Seal, Simon Taylor, Jason Witherington, Neil D Christensen
The DNA papillomaviruses infect squamous epithelium and can cause persistent, benign and sometimes malignant hyperproliferative lesions. Effective antiviral drugs to treat human papillomavirus (HPV) infection are lacking and here we investigate the anti-papillomavirus activity of novel epigenetic targeting drugs, BET bromodomain inhibitors. Bromodomain and Extra-Terminal domain (BET) proteins are host proteins which regulate gene transcription, they bind acetylated lysine residues in histones and non-histone proteins via bromodomains, functioning as scaffold proteins in the formation of transcriptional complexes at gene regulatory regions...
April 10, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29628765/low-rate-of-human-papillomavirus-vaccination-among-schoolgirls-in-lebanon-barriers-to-vaccination-with-a-focus-on-mothers-knowledge-about-available-vaccines
#14
Maria J Abou El-Ola, Mariam A Rajab, Dania I Abdallah, Ismail A Fawaz, Lyn S Awad, Hani M Tamim, Ahmad O Ibrahim, Anas M Mugharbil, Rima A Moghnieh
Background: Human papillomavirus (HPV) infection is an established predisposing factor of cervical cancer. In this study, we assessed the awareness about genital warts, cervical cancer, and HPV vaccine among mothers having girls who are at the age of primary HPV vaccination attending a group of schools in Lebanon. We also assessed the rate of HPV vaccination among these girls and the barriers to vaccination in this community. Subjects and methods: This is a cross-sectional, school-based survey...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29625768/human-papillomavirus-vaccine-acceptability-and-decision-making-among-adolescent-boys-and-parents-a-meta-ethnography-of-qualitative-studies
#15
REVIEW
Ashley Lacombe-Duncan, Peter A Newman, Philip Baiden
OBJECTIVE: Genital warts and human papillomavirus (HPV)-associated cancers in men can be substantially reduced through HPV vaccination; yet, globally, HPV vaccine uptake among boys remains low. This meta-ethnography synthesizes qualitative studies to understand, in-depth, HPV vaccine acceptability and decision-making among adolescent boys and/or their parents. METHODS: A systematic search identified qualitative studies examining HPV vaccines from the perspectives of boys and/or boys' parents...
April 3, 2018: Vaccine
https://www.readbyqxmd.com/read/29568286/inhibition-of-tgf-%C3%AE-and-notch-signaling-by-cutaneous-papillomaviruses
#16
REVIEW
Jordan M Meyers, Miranda Grace, Aayushi Uberoi, Paul F Lambert, Karl Munger
Infections with cutaneous papillomaviruses have been linked to cutaneous squamous cell carcinomas that arise in patients who suffer from a rare genetic disorder, epidermodysplasia verruciformis, or those who have experienced long-term, systemic immunosuppression following organ transplantation. The E6 proteins of the prototypical cutaneous human papillomavirus (HPV) 5 and HPV8 inhibit TGF-β and NOTCH signaling. The Mus musculus papillomavirus 1, MmuPV1, infects laboratory mouse strains and causes cutaneous skin warts that can progress to squamous cell carcinomas...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29553886/estimation-of-the-individual-residual-risk-of-cervical-cancer-after-vaccination-with-the-nonavalent-hpv-vaccine
#17
Karl-Ulrich Petry, Kaatje Bollaerts, Paolo Bonanni, Margaret Stanley, Rosybel Drury, Elmar Joura, Susanne K Kjaer, Chris J L M Meijer, Didier Riethmuller, Benoit Soubeyrand, Pierre Van Damme, Xavier Bosch
BACKGROUND: The nonavalent HPV (9vHPV) vaccine is indicated for active immunisation of individuals from the age of 9 years against cervical, vulvar, vaginal and anal premalignant lesions and cancers causally related to vaccine HPV high risk types 16, 18, 31, 33, 45, 52 and 58, and to the HPV low risk types 6 and 11, causing genital warts. OBJECTIVE: To estimate the lifetime risk (up to the age of 75 years) for developing cervical cancer after vaccinating a HPV naïve girl (e...
March 19, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29523448/substantially-reduced-incidence-of-genital-warts-in-women-and-men-six-years-after-hpv-vaccine-availability-in-sweden
#18
Eva Herweijer, Alexander Ploner, Pär Sparén
BACKGROUND: Between 2007 and 2011, opportunistic HPV-vaccination was available in Sweden and partially subsidized to girls aged 13-17, reaching a ∼30% overall coverage. METHODS: All Swedish women/men aged 15-44 were followed between 2006 and 2012 for condyloma. Average annual percent changes (AAPCs) in incidence were estimated. RESULTS: Substantial decreases were seen in women aged 15-24 from 2008-onwards (AACP-range: -8.5% to -18.5%); similar effects were seen for men aged 15-29 (AACP-range: -7...
April 5, 2018: Vaccine
https://www.readbyqxmd.com/read/29516425/infections-after-photodynamic-therapy-in-condyloma-acuminatum-patients-incidence-and-management
#19
Xin Yu, Heyi Zheng
Condyloma acuminatum (CA), or genital wart, is a sexually transmitted infection caused by human papillomaviruses. Increasing evidences demonstrated that photodynamic therapy (PDT) is effective in eliminating latent HPV infection, the major reason for CA recurrence. We observed an increasing number of infections after PDT in CA patients, which has not been reported before. This study aims to evaluate the incidence and management of infection in CA patients after PDT procedure. CA patients received PDT from January 2015 to February 2016 at the outpatient setting...
March 7, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29513235/use-of-trichloroacetic-acid-for-management-of-oral-lesions-caused-by-human-papillomavirus
#20
Martha Carmona Lorduy, Jonathan Harris Ricardo, Yurtiza Hernández Arenas, Wanda Medina Carmona
The human papillomavirus (HPV) has an affinity for squamous cells of stratified keratinized epithelium, thus affecting the lower genital, nasal, and oral tracts. In the oral cavity, HPV is associated with pathoses such as the verruca vulgaris (common wart), squamous cell papilloma, condyloma acuminatum (venereal wart), and focal epithelial hyperplasia (Heck disease). Among the treatments available for these lesions are cryotherapy, electrosurgery, surgical removal, laser therapy, and trichloroacetic acid (TCA)...
March 2018: General Dentistry
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