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https://www.readbyqxmd.com/read/28815421/knowledge-beliefs-and-attitudes-of-somali-men-in-olmsted-county-minnesota-u-s-on-the-human-papillomavirus-vaccine-and-cervical-cancer-screening-january-17-2015
#1
Uzoma Abakporo, Abdirahman Hussein, James W Begun, Tetyana Shippee
This study explores the general knowledge of Human Papillomavirus vaccine (HPV) and cervical cancer screening (CCS) among Somali men in the U.S., who are major decision-makers in Somali households. HPV infects both men and women, and causes genital warts and cervical cancer (CC). High mortality from CC persists among minorities due to low uptake of preventive tools. Eleven questions assessed general knowledge of HPV and CCS among 30 Somali male respondents. The knowledge of HPV and CCS by education level, age, and years lived in the U...
August 16, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28810862/the-cytotoxic-mechanism-of-epigallocatechin-gallate-on-proliferative-hacat-keratinocytes
#2
Yu-Wen Chu, Shu-Ting Liu, Ya-Lan Yang, Shih-Ming Huang, Wei-Ming Wang
BACKGROUND: Epigallocatechin gallate (EGCG) is the major ingredient of sinecatechins ointment, approved for the treatment of external genital and perianal warts. However, the molecular mechanism for EGCG's effect on warts resulting from the human papillomavirus (HPV) infection of keratinocytes is not well understood. HPV may survive in proliferative keratinocytes and may be involved in cell cycle regulation and progression. The objective of this study was to investigate the mechanism underlying EGCG's treatment on external genital warts of HPV infection through the cultured keratinocyte cells from the HaCaT cell line...
August 15, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28809141/hpv-11-variability-persistence-and-progression-to-genital-warts-in-men-the-him-study
#3
Ema Flores-Díaz, Karen A Sereday, Silvaneide Ferreira, Bradley Sirak, João Simão Sobrinho, Maria Luiza Baggio, Lenice Galan, Roberto C Silva, Eduardo Lazcano-Ponce, Anna R Giuliano, Luisa L Villa, Laura Sichero, The Him Study Group
HPV-11 and HPV-6 are the etiological agents of about 90 % of genital warts (GWs). The intra-typic variability of HPV-11 and its association with infection persistence and GW development remains undetermined. Here, HPV infection in men (HIM) participants who had an HPV-11 genital swab and/or GW, preceded or not by a normal skin genital swab were analysed. Genomic variants were characterized by PCR-sequencing and classified within lineages (A, B) and sublineages (A1, A2, A3, A4). HPV-11 A2 variants were the most frequently detected in the genital swab samples from controls and in both genital swabs and GW samples from cases...
August 15, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28806926/evaluation-of-vaccination-herd-immunity-effects-for-anogenital-warts-in-a-low-coverage-setting-with-human-papillomavirus-vaccine-an-interrupted-time-series-analysis-from-2005-to-2010-using-health-insurance-data
#4
Kathrin Thöne, Johannes Horn, Rafael Mikolajczyk
BACKGROUND: Shortly after the human papillomavirus (HPV) vaccine recommendation and hence the reimbursement of vaccination costs for the respective age groups in Germany in 2007, changes in the incidence of anogenital warts (AGWs) were observed, but it was not clear at what level the incidence would stabilize and to what extent herd immunity would be present. Given the relatively low HPV vaccination coverage in Germany, we aimed to assess potential vaccination herd immunity effects in the German setting...
August 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28806741/risk-of-cancer-in-patients-with-genital-warts-a-nationwide-population-based-cohort-study-in-taiwan
#5
Ching-Yi Cho, Yu-Cheng Lo, Miao-Chiu Hung, Chou-Cheng Lai, Chun-Jen Chen, Keh-Gong Wu
BACKGROUND: Condyloma acuminata currently affects around 1% of sexually active adults, and its incidence is increasing. The coexistence of genital warts (GW) and certain cancers and an association between human papillomavirus (HPV) and various malignancies have been reported. Therefore, we conducted this large national study to analyze the risk of malignancies among men and women with GW in Taiwan. METHODS AND FINDINGS: Between January 2000 and December 2013, approximately 3 million patients were reported to the National Health Insurance Research Database of Taiwan...
2017: PloS One
https://www.readbyqxmd.com/read/28805308/lymphocyte-profile-and-cytokine-mrna-expression-in-peripheral-blood-mononuclear-cells-of-patients-with-recurrent-respiratory-papillomatosis-suggest-dysregulated-cytokine-mrna-response-and-impaired-cytotoxic-capacity
#6
Anna Holm, Olga Nagaeva, Ivan Nagaev, Christos Loizou, Göran Laurell, Lucia Mincheva-Nilsson, Karin Nylander, Katarina Olofsson
OBJECTIVES: Recurrent respiratory papillomatosis (RRP) is a relatively rare, chronic disease caused by Human Papilloma Virus (HPV) 6 and 11, and characterized by wart-like lesions in the airway affecting voice and respiratory function. The majority of HPV infections are asymptomatic and resolve spontaneously, however, some individuals are afflicted with persistent HPV infections. Failure to eliminate HPV 6 and 11 due to a defect immune responsiveness to these specific genotypes is proposed to play a major role in the development of RRP...
August 14, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28801154/progress-in-prophylactic-human-papillomavirus-hpv-vaccination-in-2016-a-literature-review
#7
Polona J Maver, Mario Poljak
Prophylactic human papillomavirus (HPV) vaccine represents a revolutionary step forward in preventing HPV-related cancers, especially cervical carcinoma. Alongside appropriate screening, it has the potential to dramatically reduce cervical cancer incidence and even eradicate it. Following extensive evaluations in clinical trials, the first decade of routine HPV vaccine use provides overwhelming evidence of the vaccines' safety and their real-life effectiveness. In 2016, further clinical trials showed high vaccine efficacy in adult women, especially those that were HPV DNA-negative at baseline, and indicated possible protection from HPV-related diseases after treatment of precancerous cervical lesions...
August 8, 2017: Vaccine
https://www.readbyqxmd.com/read/28798073/the-human-papillomavirus-replication-cycle-and-its-links-to-cancer-progression-a-comprehensive-review
#8
REVIEW
Sheila V Graham
HPVs (human papillomaviruses) infect epithelial cells and their replication cycle is intimately linked to epithelial differentiation. There are over 200 different HPV genotypes identified to date and each displays a strict tissue specificity for infection. HPV infection can result in a range of benign lesions, for example verrucas on the feet, common warts on the hands, or genital warts. HPV infects dividing basal epithelial cells where its dsDNA episomal genome enters the nuclei. Upon basal cell division, an infected daughter cell begins the process of keratinocyte differentiation that triggers a tightly orchestrated pattern of viral gene expression to accomplish a productive infection...
September 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28789853/targeted-human-papillomavirus-vaccination-for-young-men-who-have-sex-with-men-in-australia-yields-significant-population-benefits-and-is-cost-effective
#9
Lei Zhang, David G Regan, Jason J Ong, Manoj Gambhir, Eric P F Chow, Huachun Zou, Matthew Law, Jane Hocking, Christopher K Fairley
BACKGROUND: We investigated the effectiveness and cost-effectiveness of a targeted human papillomavirus (HPV) vaccination program for young (15-26) men who have sex with men (MSM). METHODS: We developed a compartmental model to project HPV epidemic trajectories in MSM for three vaccination scenarios: a boys program, a targeted program for young MSM only and the combination of the two over 2017-2036. We assessed the gain in quality-adjusted-life-years (QALY) in 190,000 Australian MSM...
August 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28789851/antibody-persistence-and-evidence-of-immune-memory-at-5years-following-administration-of-the-9-valent-hpv-vaccine
#10
Ana Guevara, Robinson Cabello, Linn Woelber, Edson Duarte Moreira, Elmar Joura, Olaf Reich, Christine Shields, Misoo C Ellison, Amita Joshi, Alain Luxembourg
BACKGROUND: The 9-valent HPV (9vHPV) vaccine was developed to prevent infection and disease related to 9 HPV types (HPV6/11/16/18/31/33/45/52/58) which cause approximately 90% of cervical cancers, HPV-related vulvar, vaginal and anal cancers, and genital warts worldwide. In a pivotal efficacy study, the 9vHPV vaccine prevented infection and disease due to the 9 vaccine types. Duration of protection remains to be determined. Vaccines that induce long-term protection are generally characterized by the generation of immune memory...
August 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28771770/preliminary-study-of-analyzing-mucosal-human-papillomaviruses-in-cutaneous-warts-by-restriction-fragment-mass-polymorphism
#11
So Eun Park, Jae Won Ha, Chul Woo Kim, Sang Seok Kim
Cutaneous human papillomavirus (HPV) types 1, 2, 4, 7 and 57 are reportedly found in cutaneous warts. However, there are few reports that have investigated the prevalence of mucosal HPV types in cutaneous warts. The aim of this study is to investigate the prevalence of mucosal HPV types in patients with cutaneous warts and to determine any association between HPV types and patient characteristics. We analyzed 62 wart samples that were taken from patients who were diagnosed with cutaneous warts, and 30 normal skin samples were used as negative control...
August 3, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28770246/distinct-clinico-immunological-profile-of-patients-infected-with-human-papilloma-virus-genotypes-6-and-11
#12
Manjula Singh, Deepshi Thakral, Hemanta Kumar Kar, Narayan Rishi, Prafulla Kumar Sharma, Dipendra Kumar Mitra
Anogenital warts are primarily caused by Human Papillomavirus (HPV) type 6 and 11, which belong to the taxonomic family Papillomaviridae, genus alpha-papillomavirus and species 10. The presentation of the warts is varied and most of the patients have high recurrence rate of wart lesions. Studies had shown that an effective cellular immune response is required for the control of HPV infection. Here, we report distinct clinico-immunological profile of two patients presenting with venereal warts caused by HPV genotypes 6 and 11...
June 2017: Virusdisease
https://www.readbyqxmd.com/read/28770238/functional-characterization-of-cd4-and-cd8-t-cell-responses-among-human-papillomavirus-infected-patients-with-ano-genital-warts
#13
Manjula Singh, Deepshi Thakral, Narayan Rishi, Hemanta Kumar Kar, Dipendra Kumar Mitra
Ano-genital warts are considered one of the commonest and highly infectious sexually transmitted infections. These warts are primarily caused by the human papillomavirus (HPV) of the family Papillomaviridae, genus alpha-papillomavirus, species 10 and types 6 and 11. However the high recurrence rate of warts is a matter of serious concern to the patients and a challenge for the treating physician. The conventional treatment options are targeted only to the local site of warts. There is no systemic treatment modality as there is limited understanding of the disease immune-pathogenesis...
June 2017: Virusdisease
https://www.readbyqxmd.com/read/28768817/cxcr4-specific-nanobodies-as-potential-therapeutics-for-whim-syndrome
#14
Raymond H de Wit, Raimond Heukers, Hendrik Brink, Angela Arsova, David Maussang, Pasquale Cutolo, Beatrijs Strubbe, Henry Vischer, Francoise Bachelerie, Martine J Smit
WHIM syndrome is a rare congenital immunodeficiency disease, named after its main clinical manifestations: Warts, Hypogammaglobulinemia, Infections and Myelokathexis. The disease is primarily caused by C-terminal truncation mutations of the chemokine receptor CXCR4. Consequently, these CXCR4-WHIM mutants have a gain of function in response to its ligand CXCL12, which results in abnormal leukocyte migration and thereby immune system dysfunctions. Treatment of WHIM patients currently consists of symptom relief, leading to unsatisfactory clinical responses...
August 2, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28755837/missed-opportunities-for-catch-up-human-papillomavirus-vaccination-among-university-undergraduates-identifying-health-decision-making-behaviors-and-uptake-barriers
#15
Kathleen R Ragan, Robert A Bednarczyk, Scott M Butler, Saad B Omer
BACKGROUND: Suboptimal adolescent human papillomavirus (HPV) vaccine rates in the US highlight the need for catch-up vaccination. When teenagers enter college, there may be a shift in healthcare decision-making from parents and guardians to the students themselves. Little is known about factors influencing college students' healthcare decision-making processes. STUDY DESIGN: We evaluated HPV vaccine decision-making among 18-to-26-year-old college students through a self-administered, anonymous, cross-sectional survey...
July 26, 2017: Vaccine
https://www.readbyqxmd.com/read/28749644/the-cost-effectiveness-of-quadrivalent-human-papillomavirus-vaccination-in-indonesia
#16
Soewarta Kosen, Andrijono Andrijono, Dwiana Ocviyanti, Wresti Indriatmi
Objective: National cervical cancer prevention program has been initiated in Indonesia since April 2015 and the ministry of health has started efforts to integrate the HPV Vaccine in the national immunization program since Q4 2015. Thus, it becomes important to analyze the cost-effectiveness of HPV vaccine. The objective of this model is to examine the potential long-term epidemiologic and economic impact of quadrivalent HPV(qHPV;6/11/16/18) vaccination program in Indonesia. Methods: A previously validated transmission dynamic model was used to estimate the long-term epidemiologic and economic consequences of quadrivalent HPV vaccination by comparing cost-effectiveness of 2 dose qHPV vaccination strategy for girls 11-12 years old (with or without catch up; catch up dose for 12–26 years) versus Screening Only (Pap Smear) for reducing cost related to HPV type 6,11,16,18 (cervical cancer, CIN 1, CIN 2/3, and genital warts)...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749631/human-papillomavirus-hpv-genotype-distribution-in-patients-with-recurrent-respiratory-papillomatosis-rrp-in-iran
#17
Negin Sadat Eftekhaar, Mohammad Hadi Karbalaie Niya, Farzad Izadi, Sedigheh Teaghinezhad-S, Hossein Keyvani
Background: Currently, recurrent respiratory papillomatosis (RRP), common laryngeal warts in the upper airway systems of children and adults are on the increase. Human papillomaviruses (HPVs) are suspected as causative agents. This study concerned HPV incidence and genotype distribution in Iranian RRP patients. Methods: Specimens were collected from RRP patients referred to hospitals affiliated with Iran University of Medical Sciences, Tehran, Iran, from Dec 2014 to Feb 2016 in a cross sectional study. After DNA extraction with an QIAamp® DNA FFPE Tissue Kit, conventional PCR was performed and products were sequenced...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28742991/sexual-inactivity-and-occurrence-of-stis-in-relation-to-weight-status-in-women-two-large-population-based-studies
#18
Vibeke B Gunge, Kirsten E Juul, Adriaan Jc van den Brule, Thomas Iftner, Susanne K Kjær
The aim of this study was to examine sexual inactivity and occurrence of selected sexually transmitted infections in relation to body mass index. We used data from two large Danish population-based cross-sectional studies conducted in 1991-1995 (HPV-study: 6869 women, aged 22-32 years) and in 2004-2005 (Liva-study: 19,484 women, aged 18-45 years). Data were collected using a structured interview and measured weight, height, high-risk human papillomavirus DNA, Chlamydia DNA for the HPV-study and a structured questionnaire for the Liva-study...
July 25, 2017: Women & Health
https://www.readbyqxmd.com/read/28741750/atypical-morphology-of-anogenital-warts-is-not-a-marker-of-atypical-histology-or-of-infection-to-the-high-risk-human-papillomavirus-genotypes
#19
Pankaj Kumar, Neetu Bhari, Vishal Gupta, V G Ramachandran, Sudheer Arava, Lalit Dar, Vinod K Sharma, Kaushal K Verma, Sada N Dwivedi, Somesh Gupta
BACKGROUND: The clinical morphology of anogenital warts may vary from flat, filiform, papular, or verrucous to giant condyloma acuminatum. Clinically atypical-looking genital warts may alarm the clinician because of their suspected malignant potential, which may cause anxiety, often leading to aggressive interventions. OBJECTIVE: To study if clinically atypical-looking anogenital warts are more likely to be premalignant or malignant as compared to typical warts...
July 25, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28736973/plasmacytoid-dendritic-cells-and-type-i-interferon-in-the-immunological-response-against-warts
#20
D Saadeh, M Kurban, O Abbas
BACKGROUND: Plasmacytoid dendritic cells (pDCs) are the most potent producers of type I interferons (IFNs), and are involved in the pathogenesis of several cutaneous infectious (especially viral), inflammatory/autoimmune and neoplastic entities. Their role in the pathogenesis and regression of human papilloma virus (HPV)-induced skin lesions has not been well studied. AIM: To investigate pDC occurrence and activity in HPV-induced skin lesions, including inflamed and uninflamed warts as well as epidermodysplasia verruciformis (EDV)-associated lesions...
July 24, 2017: Clinical and Experimental Dermatology
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