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https://www.readbyqxmd.com/read/29743937/epidemiologic-and-economic-burden-of-hpv-diseases-in-spain-implication-of-additional-5-types-from-the-9-valent-vaccine
#1
Noelia López, Aureli Torné, Agustín Franco, María San-Martin, Elisabet Viayna, Carmen Barrull, Nuria Perulero
Background: A new nonavalent human papillomavirus (HPV) vaccine that includes genotypes 6/11/16/18/31/33/45/52/58 has been recently approved in Spain. A previous study has shown that attributable fraction of HPV related diseases in Spain is consistent with that reported in European and global studies. The aim of the present study was to estimate the annual direct costs associated to the following HPV-related diseases: genital warts, high grade precancerous lesions and cancer of cervix, vulva, vagina, anus and penis and head and neck cancer, caused by genotypes included in the nonavalent (9vHPV) and quadrivalent vaccines (4vHPV), in Spanish men and women...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29555573/whole-exome-sequencing-identified-mutational-profiles-of-squamous-cell-carcinomas-of-anus
#2
Sun Shin, Hyeon-Chun Park, Min Sung Kim, Mi-Ryung Han, Sung Hak Lee, Seung Hyun Jung, Sug Hyung Lee, Yeun-Jun Chung
Anal squamous cell carcinoma (ASCC), either with human papillomavirus (HPV) (+) or (-), is a neoplastic disease with frequent recurrence and metastasis. To characterize ASCC genomes, we attempted to disclose novel alterations of ASCC genomes as well as other genetic features including mutation signatures. We performed whole-exome sequencing and copy number alteration (CNA) profiling for 8 ASCC samples from 6 patients (2 cases with primary and recurrent/metastatic tumors). We found known ASCC mutations (TP53, CDKN2A and PIK3CA) and CNAs (gains on 3q and 19q and losses on 11q and 13q)...
March 16, 2018: Human Pathology
https://www.readbyqxmd.com/read/29547681/seroprevalence-of-human-papillomavirus-hpv-type-6-11-16-18-by-anatomic-site-of-hpv-infection-in-women-aged-16-64-years-living-in-the-metropolitan-area-of-san-juan-puerto-rico
#3
Aixa M Pérez-Caraballo, Erick Suarez, Elizabeth R Unger, Joel M Palefsky, Gitika Panicker, Ana Patricia Ortiz
OBJECTIVE: It is unknown if human papillomavirus (HPV) serum antibody responses vary by anatomic site of infection. We aimed to assess the seroprevalence for HPV 6, 11, 16 and 18 in association with HPV DNA detection in different anatomic sites among women. METHODS: This cross sectional population-based study analyzed data from 524 women aged 16-64 years living in the San Juan metropolitan area of Puerto Rico (PR). Questionnaires were used to assess demographic and lifestyle variables, while anogenital and blood samples were collected for HPV analysis...
March 2018: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29484001/para-and-intraurethral-penile-tumor-like-condilomatosis
#4
Anastasiya Atanasova Chokoeva, Uwe Wollina, Torello Lotti, Georgi Konstantinov Maximov, Ilia Lozev, Georgi Tchernev
Condyloma acuminata represents an epidermal manifestation, associated with the epidermotropic human papillomavirus (HPV). They have been reported as the most common sexually transmitted disease, with prevalence exceeding 50%, increased up to 4 times, within the last two decades, as the most common side of affection are the penis, vulva, vagina, cervix, perineum, and perianal area, with increased prevalence in young, sexually active individuals. Increased attention should be focused on lesions, caused by types, with moderate (33, 35, 39, 40, 43, 45, 51-56, 58) or high risk potential (types 16, 18) for malignant transformation, leading to further development of cancers of anus, vagina, vulva and penis, as well as cancers of the head and neck...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29481422/anal-and-cervical-high-risk-human-papillomavirus-genotyping-in-women-with-and-without-genital-neoplasia
#5
Amy J Bregar, Beth Cronin, Christine Luis, Paul DiSilvestro, Steven Schechter, Latha Pisharodi, Christina Raker, Melissa Clark, Katina Robison
OBJECTIVE: The aim of the study was to compare the prevalence, genotypes, and rates of concomitant anal and cervical high-risk human papillomavirus (HR-HPV) in women with and without a history of HPV-related genital neoplasia. MATERIALS AND METHODS: This was a prospective cohort study conducted from December 2012 to February 2014. Women with a history of neoplasia were considered the high-risk group. Women without a history of neoplasia were considered the low-risk group...
April 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29476028/long-term-incidence-trends-of-hpv-related-cancers-and-cases-preventable-by-hpv-vaccination-a-registry-based-study-in-norway
#6
Bo T Hansen, Suzanne Campbell, Mari Nygård
OBJECTIVES: Examine long-term incidence trends of human papillomavirus (HPV)-related cancer in Norway, and estimate the number of cancer cases preventable by vaccines against HPV 16/18 or HPV 16/18/31/33/45/52/58. DESIGN: Observational registry-based study. We extracted incident cases of HPV-related cancer during 1953-2015 from the Cancer Registry of Norway. Tumour HPV prevalence estimates from large international meta-analyses or from Norway were used to estimate the protective potential of HPV vaccines...
February 23, 2018: BMJ Open
https://www.readbyqxmd.com/read/29452366/prevalence-and-incidence-of-anal-and-cervical-high-risk-human-papillomavirus-hpv-types-covered-by-current-hpv-vaccines-among-hiv-infected-women-in-the-sun-study
#7
Erna Milunka Kojic, Lois Conley, Tim Bush, Susan Cu-Uvin, Elizabeth R Unger, Keith Henry, John Hammer, Gerome Escota, Teresa M Darragh, Joel M Palefsky, John T Brooks, Pragna Patel
Background: Nonavalent (9v) human papilloma virus vaccine targets high-risk human papillomavirus (HR-HPV) types 16, 18, 31, 33, 45, 52, 58, and low-risk 6, 11. We examined prevalence, incidence, and clearance of anal and cervical HR-HPV in HIV-infected women. Methods: The SUN Study enrolled 167 US women in 2004-2006. Anal and cervical specimens were collected annually for cytology and identification of 37 HPV types: 14 HR included: 9v 16, 18, 31, 33, 45, 52, 58; non-9v 35, 39, 51, 56, 59, 66, 68...
April 23, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29418090/s2k-leitlinie-hpv-assoziierte-l%C3%A3-sionen-der-%C3%A3-u%C3%A3-eren-genitalregion-und-des-anus-genitalwarzen-und-krebsvorstufen-der-vulva-des-penis-und-der-peri-und-intraanalen-haut-kurzfassung
#8
Gerd E Gross, Ricardo N Werner, Jürgen C Becker, Norbert H Brockmeyer, Stefan Esser, Monika Hampl, Sara Hommel, Johannes Jongen, Dominik S Mestel, Thomas Meyer, Karl U Petry, Andreas Plettenberg, Klaus Püschel, Peter Schneede, Helmut Schöfer, Karl Sotlar, Gerhard Weyandt, Ulrike Wieland, Miriam Wiese-Posselt, Alexander Nast
No abstract text is available yet for this article.
February 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29418083/s2k-guideline-hpv-associated-lesions-of-the-external-genital-region-and-the-anus-anogenital-warts-and-precancerous-lesions-of-the-vulva-the-penis-and-the-peri-and-intra-anal-skin-short-version
#9
Gerd E Gross, Ricardo N Werner, Jürgen C Becker, Norbert H Brockmeyer, Stefan Esser, Monika Hampl, Sara Hommel, Johannes Jongen, Dominik S Mestel, Thomas Meyer, Karl U Petry, Andreas Plettenberg, Klaus Püschel, Peter Schneede, Helmut Schöfer, Karl Sotlar, Gerhard Weyandt, Ulrike Wieland, Miriam Wiese-Posselt, Alexander Nast
No abstract text is available yet for this article.
February 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29182899/five-year-experience-of-the-treatment-of-squamous-cell-carcinoma-of-the-anus
#10
C A Leo, C Santorelli, J D Hodgkinson, O Bidovaneta, F Baldelli, F Cantarella, E Cavazzoni
OBJECTIVES: The best treatment of early stage anal squamous cell carcinoma (SCC) is under debated. Wide local excision (WLE) may be considered adequate for stage 1 anal margin cancer. This study demonstrates our experience in treatment of patients with SCC over 5 years. PATIENTS AND METHODS: We conducted a retrospective study of patients who had undergone anal screening or anal cancer surveillance between October 2010 and 2015 in our department. Each patient underwent anal Pap test, HPV test PCR HPV DNA and cytology by Thin Prep...
July 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29158102/human-papillomavirus-types-from-infection-to-cancer-in-the-anus-according-to-sex-and-hiv-status-a-systematic-review-and-meta-analysis
#11
Chunqing Lin, Silvia Franceschi, Gary M Clifford
BACKGROUND: Data on carcinogenicity of human papillomavirus (HPV) types in the anus are needed to inform anal cancer prevention through vaccination and screening. This is particularly the case for people infected with HIV, who are at an increased risk of anal cancer. METHODS: We did a systematic review of studies published from January, 1986, to July, 2017, in MEDLINE, Embase, and the Cochrane Library on anal HPV infection, without any language restrictions. Eligible studies reported type-specific HPV prevalence by strata of cytopathological or histopathological anal diagnosis, sex, and HIV status...
February 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29074191/prevalence-genotyping-and-correlates-of-anogenital-hpv-infection-in-a-population-based-sample-of-women-in-puerto-rico
#12
A P Ortiz, J Romaguera, C M Pérez, D González, C Muñoz, L González, E Marrero, G Tortolero-Luna, E Suárez, J Palefsky
BACKGROUND: Oncogenic HPV infection is associated to anogenital cancer. We estimate the prevalence and correlates of anogenital HPV infection among a population-based sample of women aged 16-64 years living in the metropolitan area of Puerto Rico. METHODS: 564 women completed face-to-face and computer assisted interviews and self-collected anal and cervical specimens. HPV DNA testing used MY09/MY11 consensus HPV L1 primers and beta-globin as an internal control for sample amplification...
December 2016: Papillomavirus Research
https://www.readbyqxmd.com/read/29037457/epidemiology-and-burden-of-hpv-related-disease
#13
REVIEW
Beatriz Serrano, María Brotons, Francesc Xavier Bosch, Laia Bruni
Human papillomavirus (HPV) infection is recognized as one of the major causes of infection-related cancer in both men and women. High-risk HPV types are not only responsible for virtually all cervical cancer cases but also for a fraction of cancers of the vulva, vagina, penis, anus, and head and neck cancers. Furthermore, HPV is also the cause of anogenital warts and recurrent respiratory papillomatosis. Despite the availability of multiple preventative strategies, HPV-related cancer remains a leading cause of morbi-mortality in many parts of the world, particularly in less developed countries...
February 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29037233/cancer-incidence-in-germany-attributable-to-human-papillomavirus-in-2013
#14
Nina Buttmann-Schweiger, Yvonne Deleré, Stefanie J Klug, Klaus Kraywinkel
BACKGROUND: It is estimated that a total of 120,000 new cancer cases in men and in women in more developed countries could be avoided if exposure to HPV was prevented. We used the nationwide pool of German population-based cancer registry data to estimate the burden of HPV-attributable cancer in this population for the year 2013. METHODS: Incident cases of cervical cancer, squamous cell carcinoma of the anus, oropharynx (OP), as well as of the vulva, vagina and penis were classified as potentially HPV-associated and identified from the nationwide cancer registry data-pool...
October 16, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28986092/population-based-hpv-vaccination-programmes-are-safe-and-effective-2017-update-and-the-impetus-for-achieving-better-global-coverage
#15
REVIEW
Julia M L Brotherton, Paul N Bloem
Persistent oncogenic human papillomavirus (HPV) is the cause of cervical cancer, as well as cancers of the anus, penis, vulva, vagina and oropharynx. There is good evidence that prophylactic HPV vaccines are immunogenic and effective against targeted-type HPV infections and type-specific genital lesions, including high-grade cervical intraepithelial neoplasia (CIN), when administered prior to HPV infection. There is good evidence that HPV vaccines are safe in population usage, with the most frequent adverse event being injection-site reactions...
February 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28953633/risk-factors-for-infection-by-oncogenic-human-papillomaviruses-in-hiv-positive-msm-patients-in-the-art-era-2010-2016
#16
Carmen Hidalgo-Tenorio, Concepción Gil-Anguita, Jessica Ramírez-Taboada, Javier Esquivias, Miguel A López-Ruz, Omar Mohamed Balgahata, Rosario Javier-Martinez, Juan Pasquau
Squamous cell carcinoma of anus (SCCA) is one of the most frequent non-AIDS-defining diseases in HIV patients, mainly in men who have sex with men (MSM), and it is associated with human papillomavirus (HPV) infection.To determine the prevalence of high-risk HPV (HR-HPV) genotypes, premalignant lesions (HSIL) and SCCA in a cohort of HIV-positive MSM; to study the distribution of HPV genotypes according to anal histology results; and to analyze risk factors for this infection.This prospective single-center study was conducted between May 2010 and September 2016...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28843621/early-detection-of-hiv-infection-and-of-asymptomatic-sexually-transmitted-infections-among-men-who-have-sex-with-men
#17
Josep Coll, Sebastián Videla, Agathe Leon, Arelly Ornelas, Felipe García, Emma Fernández, José Luis Blanco, Antonio Carrillo, Isabel Bravo, Michael Meulbroek, Francesc García-Cuyas, Victoria González, Jordi Casabona, Lorna Leal, Bonaventura Clotet, Christian Brander
OBJECTIVE: To provide data on incidence of early diagnosis of HIV infections and define prevalence and incidence of asymptomatic STI in MSM. METHODS: Prospective cohort study of HIV-uninfected MSM at high-risk for HIV-infection. Participants were selected through a risk-assessment questionnaire, and screened for HIV-infection (quarterly) and for other STIs (yearly): syphilis, hepatitis A, B and C (serology); C. trachomatis and N. gonorrhoeae in penis and rectum and Human Papillomavirus in anus and mouth (PCR)...
August 23, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28708948/hospitalizations-associated-with-malignant-neoplasia-and-in-situ-carcinoma-in-the-anus-and-penis-in-men-and-women-during-a-5-year-period-2009-2013-in-spain-an-epidemiological-study
#18
Noelia López, Ángel Gil-de-Miguel, Raquel Pascual-García, Ruth Gil-Prieto
BACKGROUND: Approximately 40,000 new cases of anal cancer and 26,000 new cases of penile cancer occurred in 2012 worldwide. Human Papillomavirus (HPV) infection is responsible for 88.3% and 33.0% of these cancers, respectively. The aim of this study was to describe the hospital burden associated with malignant neoplasm (MN) and in situ carcinoma (ISC) in the anus and penis in Spain from 2009 to 2013. METHODS: This observational, retrospective study used discharge information obtained from the national surveillance system for hospital data, Conjunto Mínimo Básico de Datos, provided by the Ministry of Health...
October 3, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28688605/human-papillomavirus-prevalence-in-the-anus-and-urine-among-hiv-infected-japanese-men-who-have-sex-with-men
#19
Hiroshi Yaegashi, Kazuyoshi Shigehara, Ichiro Itoda, Mitsuaki Ohkodo, Kazufumi Nakashima, Shohei Kawaguchi, Mikio Ueda, Koji Izumi, Yoshifumi Kadono, Hiroko Ikeda, Mikio Namiki, Atsushi Mizokami
BACKGROUND: The present study investigated human papillomavirus (HPV) prevalence in anal and urine samples, and evaluated cytological findings among human immunodeficiency virus (HIV)-infected Japanese men who have sex with men (MSM). METHODS: A total of 148 patients were enrolled. Anal and urine samples were collected from each participant, and a HPV-DNA test and genotyping were performed using flow-through hybridization. In addition, anal cytology was evaluated based on Papanicolaou staining...
September 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28641314/no-additional-prognostic-value-for-mre11-in-squamous-cell-carcinomas-of-the-anus-treated-with-chemo-radiotherapy
#20
Alexandra K Walker, Christiana Kartsonaki, Elena Collantes, Judith Nicholson, Duncan C Gilbert, Anne E Kiltie
BACKGROUND: The majority of anal cancers (84-95%) are driven by infection with human papillomavirus (HPV). HPV-positive tumours show significantly better responses to chemo-radiotherapy when compared with HPV-negative tumours. HPV infection is linked to alterations in DNA damage response proteins, including MRE11. MRE11 is a potential predictive biomarker for response to radiotherapy in muscle-invasive bladder cancer and may hold predictive power in other cancers. METHODS: Using a previously reported cohort, we evaluated the levels of MRE11 in anal cancer and assessed its predictive value in this disease...
July 25, 2017: British Journal of Cancer
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