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https://www.readbyqxmd.com/read/27864489/protecting-women-against-human-papillomavirus-benefits-barriers-and-evidence-based-strategies-to-increase-vaccine-uptake
#1
Tamera Coyne-Beasley, Bridget E Hochwalt
Human papillomavirus (HPV) infection significantly impacts women, as it can cause cancers and precancers of the cervix, vulva, vagina, oropharynx, and anus. However, many of these cancers can be prevented by HPV vaccination. Despite evidence of vaccine effectiveness and safety, vaccination rates remain low. Evidence-based strategies should be utilized to reduce barriers and increase vaccination rates.
November 2016: North Carolina Medical Journal
https://www.readbyqxmd.com/read/27706233/dysregulation-of-autophagy-contributes-to-anal-carcinogenesis
#2
Evie H Carchman, Kristina A Matkowskyj, Louise Meske, Paul F Lambert
INTRODUCTION: Autophagy is an intracellular catabolic process that removes and recycles unnecessary/dysfunctional cellular components, contributing to cellular health and survival. Autophagy is a highly regulated cellular process that responds to several intracellular signals, many of which are deregulated by human papillomavirus (HPV) infection through the expression of HPV-encoded oncoproteins. This adaptive inhibitory response helps prevent viral clearance. A strong correlation remains between HPV infection and the development of squamous cell carcinoma (SCC) of the anus, particularly in HIV positive and other immunosuppressed patients...
2016: PloS One
https://www.readbyqxmd.com/read/27672265/human-papillomavirus-and-gastrointestinal-cancer-a-review
#3
REVIEW
Dania Bucchi, Fabrizio Stracci, Nicola Buonora, Giuseppe Masanotti
Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide. Exposure to HPV is very common, and an estimated 65%-100% of sexually active adults are exposed to HPV in their lifetime. The majority of HPV infections are asymptomatic, but there is a 10% chance that individuals will develop a persistent infection and have an increased risk of developing a carcinoma. The International Agency for Research on Cancer has found that the following cancer sites have a strong causal relationship with HPV: cervix uteri, penis, vulva, vagina, anus and oropharynx, including the base of the tongue and the tonsils...
September 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27659388/-condydav-a-multicentre-observational-study-of-patients-presenting-external-genital-warts-in-france
#4
J Chanal, S Fouéré, F Yassir-Oria, N Spenatto, F Bouscarat, E Picot, P Martinet, C Vernay-Vaisse, F Pelletier, C Courtieu, V Baclet, C Bernier, D Aymar-Moulene, F Dupuis-Fourdan, A Passeron, C Bara-Passot, A-L Pinault, L Misery, M Janier, N Dupin
BACKGROUND: Since 2007 in France, human papilloma virus (HPV) vaccination has been licensed for use as a vaccine against HPV 6, 11, 16 and 18. The impact on the epidemiology of external genital warts (EGWs) in a large population remains unclear. OBJECTIVES: To determine epidemiologic and clinical features of patients presenting EGWs in France in the era of HPV vaccination. PATIENTS AND METHODS: In this prospective, observational study, we analyzed clinical features and treatments between January 1st, 2012 and March 31, 2012 for patients consulting for EGWs at 15 STI clinics throughout France...
September 19, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27523740/immunogenicity-of-next-generation-hpv-vaccines-in-non-human-primates-measles-vectored-hpv-vaccine-versus-pichia-pastoris-recombinant-protein-vaccine
#5
Gaurav Gupta, Viviana Giannino, Narayan Rishi, Reinhard Glueck
Human papillomavirus (HPV) infection is the most common sexually transmitted disease worldwide. HPVs are oncogenic small double-stranded DNA viruses that are the primary causal agent of cervical cancer and other types of cancers, including in the anus, oropharynx, vagina, vulva, and penis. Prophylactic vaccination against HPV is an attractive strategy for preventing cervical cancer and some other types of cancers. However, there are few safe and effective vaccines against HPV infections. Current first-generation commercial HPV vaccines are expensive to produce and deliver...
September 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27415639/incidence-of-oropharyngeal-cancer-among-elderly-patients-in-the-united-states
#6
Zachary S Zumsteg, Galen Cook-Wiens, Emi Yoshida, Stephen L Shiao, Nancy Y Lee, Alain Mita, Christie Jeon, Marc T Goodman, Allen S Ho
Importance: An escalating incidence of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) has been reported predominantly among middle-aged adults. However, HPV infection is believed to occur many years before cancer develops, and tissue studies suggest that HPV DNA is found in the majority of OPSCC diagnosed in patients 65 years or older. Objective: To update the trends in OPSCC incidence using US cancer registry data, with an emphasis on age-specific trends...
December 1, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27094835/determination-of-oncogenic-human-papillomavirus-hpv-genotypes-in-anogenital-cancers-in-myanmar
#7
Mu Mu Shwe, Hlaing Myat Thu, Khin Saw Aye, Aye Aye Myint, Mya Thida, Khin Shwe Mar, Khin Khin Oo, Khin Sandar Aye, Shigeru Okada, Kyaw Zin Thant
Molecular and epidemiologic investigations suggest a causal role for human papillomavirus (HPV) in anogenital cancers. This study identified oncogenic HPV genotypes in anogenital cancers among men and women in a 2013 cross-sectional descriptive study in Myanmar. In total, 100 biopsy tissues of histologically confirmed anogenital cancers collected in 2008-2012 were studied, including 30 penile and 9 anal cancers from Yangon General Hospital and 61 vulvar cancers from Central Women's Hospital, Yangon. HPV-DNA testing and genotyping were performed by polymerase chain reaction-restriction fragment length polymorphism...
2016: Acta Medica Okayama
https://www.readbyqxmd.com/read/27084683/estimating-the-cost-effectiveness-profile-of-a-universal-vaccination-programme-with-a-nine-valent-hpv-vaccine-in-austria
#8
L Boiron, E Joura, N Largeron, B Prager, M Uhart
BACKGROUND: HPV is a major cancer-causing factor in both sexes in the cervix, vulva, vagina, anus, penis, oropharynx as well as the causal factor in other diseases such as genital warts and recurrent respiratory papillomatis. In the context of the arrival of a nonavalent HPV vaccine (6/11/16/18/31/33/45/52/58), this analysis aims to estimate the public health impact and the incremental cost-effectiveness of a universal (girls and boys) vaccination program with a nonavalent HPV vaccine as compared to the current universal vaccination program with a quadrivalent HPV vaccine (6/11/16/18), in Austria...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27069958/papillary-urothelial-carcinoma-with-squamous-differentiation-in-association-with-human-papilloma-virus-case-report-and-literature-review
#9
Sergei Guma, Remegio Maglantay, Ryan Lau, Rosemary Wieczorek, Jonathan Melamed, Fang-Ming Deng, Ming Zhou, Danil Makarov, Peng Lee, Matthew R Pincus, Zhi-Heng Pei
BACKGROUND: The human papilloma virus (HPV) is a carcinogen known for its strong association with cervical cancers and cervical lesions. It is also known to be associated with a variety of squamous cell carcinomas in other areas, such as the penis, vulva, anus and head and neck. However, the association with urothelial carcinoma remains controversial. Here, we report a case of urothelial carcinoma with squamous differentiation associated with HPV-6/HPV-11. CASE PRESENTATION: This is a case of a 70 year old man who presented with nocturia and pressure during urination...
2016: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/26866355/basaloid-squamous-cell-carcinoma-of-the-anus-revisited
#10
Rondell P Graham, Christina A Arnold, Bita V Naini, Dora M Lam-Himlin
Basaloid squamous cell carcinoma (SCC) of the anus, previously called cloacogenic carcinoma, is a subtype of SCC. There are very few data on the morphologic variation within basaloid SCC of the anus, which may contribute to misdiagnosis. We retrospectively evaluated cases originally diagnosed as basaloid SCC for histologic characterization. We retrieved and reviewed cases of basaloid SCC from 1994 to 2013. Ten (27%) cases were reclassified after review, including basal cell carcinoma (n=6), melanoma (n=2), and neuroendocrine carcinoma (n=2)...
March 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26538554/anal-dysplasia-in-hiv-infected-women-a-commentary-on-the-field
#11
Catherine Godfrey, Cynthia S Firnhaber, Gypsyamber D'Souza, Isabelle Heard
Anal cancer may be an emerging clinical problem in HIV-infected women particularly in resource-limited settings. Human papillomavirus (HPV) infection is a precursor to anal cancer and is prevalent in HIV-infected women, but the natural history of HPV infection and anal cancer precursors is not well described in this population. It is not known which specific dysplastic lesions in the anus are most likely to progress, and whether treatment of high grade squamous intraepithelial lesion reduces the incidence of anal cancer in women...
November 4, 2015: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/26520047/hpv-vaccination-to-prevent-oropharyngeal-carcinoma-what-can-be-learned-from-anogenital-vaccination-programs
#12
REVIEW
Robert P Takes, Małgorzata Wierzbicka, Gypsyamber D'Souza, Joanna Jackowska, Carl E Silver, Juan P Rodrigo, Frederik G Dikkers, Kerry D Olsen, Alessandra Rinaldo, Ruud H Brakenhoff, Alfio Ferlito
Human papillomavirus (HPV) infections are well known causes of anogenital cancers. Recent studies show that HPV also plays a role in oropharyngeal cancer (OPC). A review on the role of HPV vaccination in the prevention of head and neck squamous cell carcinoma (HNSCC) with special emphasis on OPC was conducted and available vaccines and vaccination strategies in HNSCC and OPC are discussed. Prophylactic vaccination is known to be effective for prevention of anogenital HPV infection and precursor lesions in the cervix and anus...
December 2015: Oral Oncology
https://www.readbyqxmd.com/read/26437730/cancers-in-australia-in-2010-attributable-to-infectious-agents
#13
Annika Antonsson, Louise F Wilson, Bradley J Kendall, Christopher J Bain, David C Whiteman, Rachel E Neale
OBJECTIVES: To estimate the proportion and numbers of cancers in Australia in 2010 attributable to infectious agents. METHODS: The population attributable fraction (PAF) and number of cancers caused by hepatitis B and C viruses (HBV, HCV), Helicobacter pylori and human immunodeficiency virus (HIV) were calculated using standard formulae incorporating prevalence of infection in the Australian population, the relative risks associated with that infection and cancer incidence...
October 2015: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/26262638/mate-pair-sequencing-as-a-powerful-clinical-tool-for-the-characterization-of-cancers-with-a-dna-viral-etiology
#14
REVIEW
Ge Gao, David I Smith
DNA viruses are known to be associated with a variety of different cancers. Human papillomaviruses (HPV) are a family of viruses and several of its sub-types are classified as high-risk HPVs as they are found to be associated with the development of a number of different cancers. Almost all cervical cancers appear to be driven by HPV infection and HPV is also found in most cancers of the anus and at least half the cancers of the vulva, penis and vagina, and increasingly found in one sub-type of head and neck cancers namely oropharyngeal squamous cell carcinoma...
August 2015: Viruses
https://www.readbyqxmd.com/read/26245727/hpv-vaccine-uptake-among-canadian-youth-and-the-role-of-the-nurse-practitioner
#15
Katlyn Scott, Mary Lou Batty
The human papillomavirus (HPV) infects approximately 550,000 Canadians annually. Cancers of the cervix, mouth, anus, throat and neck are caused by various strains of the virus. The virus also causes genital warts. The disease and economic burden of HPV is high. Primary prevention through vaccine administration prior to onset of sexual activity is evidenced as best practice. Two vaccines are available, Gardasil and Cervarix. Consistent with global practices in developed countries, these vaccines are currently publicly funded for females and provided in school-based clinics in all provinces and territories in Canada...
February 2016: Journal of Community Health
https://www.readbyqxmd.com/read/26181161/perianal-infection-of-highly-oncogenic-human-papilloma-virus-how-to-prevent-from-cancer-case-report
#16
Katarzyna Borycka-Kiciak, Agnieszka Białas, Jarosław Wejman, Małgorzata Uchman-Musielak, Wiesław Tarnowski
The presence of oncogenic types of human papilloma virus (HPV) in location of the anus is related to anal carcinoma. However, there is little knowledge about the natural history of such infections in patients outside risk groups, its relation to cervical cancer, the risk of anal cancer development as well as any way to prevent it. There are no standard procedures in the case of finding of HPV-associated anal intraepithelial neoplasia in the perianal area. Case report describes an incidental finding of a highly oncogenic type of HPV discovered in a histopathological assessment of a 48-year old woman after a haemorrhoidectomy...
2015: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/26121913/human-papillomavirus-genotype-attribution-for-hpvs-6-11-16-18-31-33-45-52-and-58-in-female-anogenital-lesions
#17
MULTICENTER STUDY
Beatriz Serrano, Silvia de Sanjosé, Sara Tous, Beatriz Quiros, Nubia Muñoz, Xavier Bosch, Laia Alemany
OBJECTIVE: Human papillomavirus (HPV) vaccines can potentially control cervical cancer and help to reduce other HPV-related cancers. We aimed to estimate the relative contribution (RC) of the nine types (HPVs 16/18/31/33/45/52/58/6/11) included in the recently approved 9-valent HPV vaccine in female anogenital cancers and precancerous lesions (cervix, vulva, vagina and anus). METHODS: Estimations were based on an international study designed and coordinated at the Catalan Institute of Oncology (Barcelona-Spain), including information on 10,575 invasive cervical cancer (ICC), 1709 vulvar, 408 vaginal and 329 female anal cancer cases and 587 Vulvar Intraepitelial Neoplasia grade 2/3 (VIN2/3), 189 Vaginal Intraepitelial Neoplasia grade 2/3 (VaIN2/3) and 29 Anal Intraepitelial Neoplasia grade 2/3 (AIN2/3) lesions...
September 2015: European Journal of Cancer
https://www.readbyqxmd.com/read/26002318/prevalence-and-concordance-of-human-papillomavirus-infection-at-multiple-anatomic-sites-among-hiv-infected-women-from-chennai-india
#18
Lynette J Menezes, Selvamuthu Poongulali, Massimo Tommasino, Hui-Yi Lin, Nagalingeswaran Kumarasamy, Kate J Fisher, Shanmugam Saravanan, Tarik Gheit, Chandrasekaran Ezhilarasi, Arumugham Jeeva, Beibei Lu, Anna R Giuliano
Human papillomavirus (HPV) infection at the cervix, anus and oropharynx has been rarely concurrently estimated among HIV-infected women. Using multiplex polymerase chain reaction testing, we prospectively evaluated HPV genotype distribution across three anatomic sites among 50 eligible HIV-infected women from Chennai, India, who provided biological specimens and answered a sexual behaviour questionnaire. We also assessed clinical and behavioural factors related to HPV prevalence. Oncogenic HPV prevalence was comparable between the anus and cervix at 52...
June 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/25975286/microanatomy-of-the-cervical-and-anorectal-squamocolumnar-junctions-a-proposed-model-for-anatomical-differences-in-hpv-related-cancer-risk
#19
Eric J Yang, Matthew C Quick, Suchanan Hanamornroongruang, Keith Lai, Leona A Doyle, Frank D McKeon, Wa Xian, Christopher P Crum, Michael Herfs
Human papilloma virus (HPV) infection causes cancers and their precursors (high-grade squamous intraepithelial lesions) near cervical and anal squamocolumnar junctions. Recently described cervical squamocolumnar junction cells are putative residual embryonic cells near the cervical transformation zone. These cells appear multipotential and share an identical immunophenotype (strongly CK7-positive) with over 90% of high-grade squamous intraepithelial lesions and cervical carcinomas. However, because the number of new cervical cancers discovered yearly world wide is 17-fold that of anal cancer, we posed the hypothesis that this difference in cancer risk reflects differences in the transition zones at the two sites...
July 2015: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/25964524/the-role-of-human-papilloma-virus-in-urological-malignancies
#20
REVIEW
Isabel Heidegger, Wegene Borena, Renate Pichler
Human papillomavirus (HPV) is associated with cancer of the cervix uteri, penis, vulva, vagina, anus and oropharynx. However, the role of HPV infection in urological tumors is not yet clarified. HPV appears not to play a major causative role in renal and testicular carcinogenesis. However, HPV infection should be kept in mind regarding cases of prostate cancer, as well as in a sub-group of patients with bladder cancer with squamous differentiation. Concerning the role of HPV in penile cancer incidence, it is a recognized risk factor proven in a large number of studies...
May 2015: Anticancer Research
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