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JOURNAL ARTICLE
Taisa Lima, Vick Brito Oliveira
This paper reflects on the Family Health Strategy (ESF) workers' understanding of racial relationships and health intersections. We conducted semi-structured interviews with ESF teams' professionals in the State of Pernambuco, Brazil, whose data were analyzed in light of the discussions that focused on the racial theme. The results point to discrepancies between different health models in the daily routine, race/skin color invisibility in training and professional work, and whiteness as a structuring element of race relationships...
August 2023: Ciência & Saúde Coletiva
#2
JOURNAL ARTICLE
Eleder Cachorro, Mario Günscht, Mario Schubert, Mirna S Sadek, Johanna Siegert, Fabian Dutt, Carla Bauermeister, Susann Quickert, Henrick Berning, Felix Nowakowski, Simon Lämmle, Rebecca Firneburg, Xiaojing Luo, Stephan R Künzel, Erik Klapproth, Peter Mirtschink, Manuel Mayr, Matthias Dewenter, Christiane Vettel, Jordi Heijman, Kristina Lorenz, Kaomei Guan, Ali El-Armouche, Michael Wagner, Susanne Kämmerer
BACKGROUND: Ventricular arrhythmia and sudden cardiac death are the most common lethal complications after myocardial infarction. Antiarrhythmic pharmacotherapy remains a clinical challenge and novel concepts are highly desired. Here, we focus on the cardioprotective CNP (C-type natriuretic peptide) as a novel antiarrhythmic principle. We hypothesize that antiarrhythmic effects of CNP are mediated by PDE2 (phosphodiesterase 2), which has the unique property to be stimulated by cGMP to primarily hydrolyze cAMP...
January 30, 2023: Circulation Research
#3
JOURNAL ARTICLE
Juan Carlos Antuña-Sánchez, Roberto Román, Juan Luis Bosch, Carlos Toledano, David Mateos, Ramiro González, Victoria Cachorro, Ángel de Frutos
This paper presents the software application ORION (All-sky camera geOmetry calibRation from star positIONs). This software has been developed with the aim of providing geometrical calibration to all-sky cameras, i.e. assess which sky coordinates (zenith and azimuth angles) correspond to each camera pixel. It is useful to locate bodies over the celestial vault, like stars and planets, in the camera images. The user needs to feed ORION with a set of cloud-free sky images captured at night-time for obtaining the calibration matrices...
2022: PloS One
#4
JOURNAL ARTICLE
Michael Wagner, Mirna S Sadek, Nataliya Dybkova, Fleur E Mason, Johann Klehr, Rebecca Firneburg, Eleder Cachorro, Kurt Richter, Erik Klapproth, Stephan R Kuenzel, Kristina Lorenz, Jordi Heijman, Dobromir Dobrev, Ali El-Armouche, Samuel Sossalla, Susanne Kämmerer
BACKGROUND: Phosphodiesterases (PDE) critically regulate myocardial cAMP and cGMP levels. PDE2 is stimulated by cGMP to hydrolyze cAMP, mediating a negative crosstalk between both pathways. PDE2 upregulation in heart failure contributes to desensitization to β-adrenergic overstimulation. After isoprenaline (ISO) injections, PDE2 overexpressing mice (PDE2 OE) were protected against ventricular arrhythmia. Here, we investigate the mechanisms underlying the effects of PDE2 OE on susceptibility to arrhythmias...
May 1, 2021: International Journal of Molecular Sciences
#5
JOURNAL ARTICLE
S R Bornstein, K Guan, C Brunßen, G Mueller, V Kamvissi-Lorenz, R Lechler, R Trembath, M Mayr, L Poston, R Sancho, S Ahmed, E Alfar, B Aljani, T C Alves, S Amiel, C L Andoniadou, M Bandral, A Belavgeni, I Berger, A Birkenfeld, E Bonifacio, T Chavakis, P Chawla, P Choudhary, A M Cujba, L F Delgadillo Silva, T Demcollari, D M Drotar, S Duin, N N El-Agroudy, A El-Armouche, A Eugster, M Gado, A Gavalas, M Gelinsky, M Guirgus, S Hansen, E Hanton, M Hasse, H Henneicke, C Heller, H Hempel, C Hogstrand, D Hopkins, L Jarc, P M Jones, M Kamel, S Kämmerer, A J F King, A Kurzbach, C Lambert, Y Latunde-Dada, I Lieberam, J Liers, J W Li, A Linkermann, S Locke, B Ludwig, T Manea, F Maremonti, Z Marinicova, B M McGowan, M Mickunas, G Mingrone, K Mohanraj, H Morawietz, N Ninov, M Peakman, S J Persaud, J Pietzsch, E Cachorro, T J Pullen, I Pyrina, F Rubino, A Santambrogio, F Schepp, P Schlinkert, L D Scriba, R Siow, M Solimena, F M Spagnoli, S Speier, A Stavridou, C Steenblock, A Strano, P Taylor, A Tiepner, W Tonnus, T Tree, F Watt, M Werdermann, M Wilson, N Yusuf, C G Ziegler
Currently, we are experiencing a true pandemic of a communicable disease by the virus SARS-CoV-2 holding the whole world firmly in its grasp. Amazingly and unfortunately, this virus uses a metabolic and endocrine pathway via ACE2 to enter our cells causing damage and disease. Our international research training programme funded by the German Research Foundation has a clear mission to train the best students wherever they may come from to learn to tackle the enormous challenges of diabetes and its complications for our society...
March 2021: Hormone and Metabolic Research
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REVIEW
Mirna S Sadek, Eleder Cachorro, Ali El-Armouche, Susanne Kämmerer
Phosphodiesterases (PDEs) are the principal superfamily of enzymes responsible for degrading the secondary messengers 3',5'-cyclic nucleotides cAMP and cGMP. Their refined subcellular localization and substrate specificity contribute to finely regulate cAMP/cGMP gradients in various cellular microdomains. Redistribution of multiple signal compartmentalization components is often perceived under pathological conditions. Thereby PDEs have long been pursued as therapeutic targets in diverse disease conditions including neurological, metabolic, cancer and autoimmune disorders in addition to numerous cardiovascular diseases (CVDs)...
October 10, 2020: International Journal of Molecular Sciences
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JOURNAL ARTICLE
Javier Vaquero-Martínez, Manuel Antón, Roberto Román, Victoria E Cachorro, Huiqun Wang, Gonzalo González Abad, Christoph Ritter
The European Arctic is a region of high interest for climate change. Water vapor plays a fundamental role in global warming; therefore, high-quality water vapor monitoring is essential for assimilation in forecast simulations. The seven analyzed instruments on-board satellite platforms are: Atmospheric Infrared Sounder (AIRS), Global Ozone Monitoring Instrument 2 (GOME-2), Moderate-Resolution Imaging Spectroradiometer (MODIS), Ozone Monitoring Instrument (OMI), SCanning Imaging Absorption Spectrometer for Atmospheric Carthography (SCIAMACHY) and Polarization and Directionality of the Earth's Reflectances (POLDER)...
November 1, 2020: Science of the Total Environment
#8
JOURNAL ARTICLE
Patrícia Fernanda Pereira Cabral, Marcelo Henrique Lopes Silva, Iranaldo Santos da Silva, Antonio Carlos Leal de Castro
Impacts on urban water resources are invariably caused by the development of urban centers and the occupation of the watershed. The release of untreated effluents and urban runoff are sources of metals in adjacent water bodies. It is therefore important to conduct studies on the occurrence of these trace elements in the environment and the risks posed to human health. The aim of the present study was to determine Cd, Pb, Cu, and Zn concentrations in water bodies located in the Bacanga and Cachorros watersheds and correlate the occurrence of these elements with physicochemical variables of the water (temperature, pH, dissolved oxygen, and electrical conductivity)...
July 11, 2020: Bulletin of Environmental Contamination and Toxicology
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JOURNAL ARTICLE
Leonardo Barroso de Melo, Ronildo Baiatone Alencar, Vera Margarete Scarpassa
Leishmaniasis is considered one of the six most important infectious diseases in the world. In spite of its importance, the leishmaniasis is one of the world's most neglected tropical diseases. Bichromomyia flaviscutellata sensu lato is a complex composed of at least three species: B. flaviscutellata sensu stricto, B. reducta and B. olmeca. The latter is composed of three subspecies: B. olmeca olmeca, B. olmeca bicolor and B. olmeca nociva, which are distributed from Central America to South America. Of these, B...
July 2020: Infection, Genetics and Evolution
#10
JOURNAL ARTICLE
Javier Vaquero-Martínez, Manuel Antón, José Pablo Ortiz de Galisteo, Roberto Román, Victoria E Cachorro, David Mateos
Integrated water vapor (IWV) data from Global Navigation Satellite Systems (GNSS) and radiosounding (RS) are compared over four sites (Lindenberg, Ny-Ålesund, Lauder and Sodankylä), which are part of the Global Climate Observing System (GCOS) Reference Upper Air Network (GRUAN). Both datasets show an excellent agreement, with a high degree of correlation (R2 over 0.98). Dependences of GNSS-RS differences on several variables are studied in detail. Mean bias error (MBE) and standard deviation (SD) increase with IWV, but in relative term, these variables decrease as IWV increases...
January 15, 2019: Science of the Total Environment
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JOURNAL ARTICLE
Weider H P Paz, Richardson A de Almeida, Neila A Braga, Felipe M A da Silva, Leonard D R Acho, Emerson S Lima, Ana Paula A Boleti, Edson L Dos Santos, Célio F F Angolini, Giovana A Bataglion, Hector H F Koolen
Remela de cachorro (Clavija lancifolia Desf.) is an Amazonian native fruit consumed specially in the Purus microregion. Because of its rarity, restricted consumption, and the lack of knowledge about its chemical composition, remela de cachorro fruit was studied in relation to its phenolic and aroma constitution. Using liquid chromatography tandem mass spectrometry (LC-MS/MS), 11 compounds (flavonoids and its glucosides along with organic acids) were tentatively identified by fragmentation patterns. A previously validated method was applied to quantify common antioxidant compounds in the raw pulps, for which kaempferol was the main compound...
July 2018: Food Research International
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JOURNAL ARTICLE
Daniela M Farias, Maria S Ostetto, Rozimeri Colleti, Thais Barbosa, Jorge A Barros, Sergio Machado, Eric Murillo-Rodríguez, Susana E Moreno, Andre B Veras
BACKGROUND: Effect of Heteropterys aphrodisiaca (dog-node) on anxiety and function of adult female wistar mice. The project is an experiment with the use of H. aphrodisiac root extract, in order to observe the frequency of sexual exposure of females exposed to the extract, quantify the effect of the extract on the concentration of total testosterone and observe the anxiety levels of the animals exposed. Results will be measured with the laboratory testosterone test and LCE and CA tests...
2017: Current Clinical Pharmacology
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COMPARATIVE STUDY
S Mogo, J F López, V E Cachorro, A de Frutos, R Zocca, A Barroso, D Mateos, E Conceição
Continuous measurements of the optical properties of aerosol particles have been made at Valladolid, Spain, covering the period from June 2011 to July 2012. The measurements were made at two size cuts: sub-10 μm and sub-1 μm (PM10 and PM1). The data measured were the scattering and backscattering coefficients, σs and σbs , obtained from an integrating nephelometer, and the absorption coefficient, σa , obtained from a particle soot absorption photometer. Spectrally resolved data were obtained from both instruments at 3 wavelengths (blue/green/red) at low relative humidity (RH < 40%)...
February 22, 2017: Environmental Science. Processes & Impacts
#14
JOURNAL ARTICLE
Javier Vaquero-Martínez, Manuel Antón, José Pablo Ortiz de Galisteo, Victoria E Cachorro, Huiqun Wang, Gonzalo González Abad, Roberto Román, Maria João Costa
This paper shows the validation of integrated water vapor (IWV) measurements retrieved from the Ozone Monitoring Instrument (OMI), using as reference nine ground-based GPS stations in the Iberian Peninsula. The study period covers from 2007 to 2009. The influence of two factors, - solar zenith angle (SZA) and IWV -, on OMI-GPS differences was studied in detail, as well as the seasonal dependence. The pseudomedian of the relative differences is -1 ± 1% and the inter-quartile range (IQR) is 41%. Linear regressions calculated over each station show an acceptable agreement (R2 up to 0...
February 15, 2017: Science of the Total Environment
#15
JOURNAL ARTICLE
M A Burgos, D Mateos, V E Cachorro, C Toledano, A M de Frutos
To broaden the knowledge about desert dust (DD) aerosols in western Mediterranean Basin, their fingerprints on optical and microphysical properties are analyzed during DD episodes in the north-central plateau of the Iberian Peninsula between 2003 and 2014. Aerosol columnar properties obtained from the AErosol RObotic NETwork (AERONET), such as aerosol optical depth (AOD), Ångström exponent (AE), volume particle size distribution, volume concentration (VC), sphericity, single scattering albedo, among others, are analyzed in order to provide a general characterization, being some of them compared to particle mass surface concentrations PM10 , PM2...
December 1, 2016: Science of the Total Environment
#16
JOURNAL ARTICLE
Cecilia Gil Polo, Esther Cubo Delgado, Ana Mateos Cachorro, Jéssica Rivadeneyra Posadas, Natividad Mariscal Pérez, Diana Armesto Formoso
INTRODUCTION: Little is known about the energy needs in Huntington's disease (HD). The aims of this study are to analyze and compare the total energy expenditure (TEE) and energy balance (EB) in a representative sample of HD patients with healthy controls. METHODS: This is an observational, case-control single-center study. Food caloric energy intake (EI) and TEE were considered for estimating EB. A dietary recall questionnaire was used to assess the EI. TEE was computed as the sum of resting energy expenditure (REE), measured by indirect calorimetry and physical activity (PA) monitored by an actigraph...
2015: Annals of Nutrition & Metabolism
#17
JOURNAL ARTICLE
R Román, M Antón, V E Cachorro, D Loyola, J P Ortiz de Galisteo, A de Frutos, P M Romero-Campos
Water vapor column (WVC) obtained by GOME-2 instrument (GDP-4.6 version) onboard MetOp-A satellite platform is compared against reference WVC values derived from GPS (Global Positioning System) instruments from 2007 to 2012 at 21 places located at Iberian Peninsula. The accuracy and precision of GOME-2 to estimate the WVC is studied for different Iberian Peninsula zones using the mean (MBE) and the standard deviation (SD) of the GOME-2 and GPS differences. A direct comparison of all available data shows an overestimation of GOME-2 compared to GPS with a MBE of 0...
November 15, 2015: Science of the Total Environment
#18
JOURNAL ARTICLE
D Mateos, V E Cachorro, C Toledano, M A Burgos, Y Bennouna, B Torres, D Fuertes, R González, C Guirado, A Calle, A M de Frutos
The study of atmospheric aerosol load over the Iberian Peninsula (IP) under a climatological perspective is accomplished by means of PM10 and AOD440 nm measurements from EMEP and AERONET networks, respectively, in the period 2000-2013. The PM10 annual cycles in five Iberian sectors show a main maximum in summer and a secondary maximum in spring, which is only observed in the southern area for the AOD climatology. The characteristics of PM10-AOD annual cycles of each geographical sector are explained by the different climatology of the air mass origins and their apportioning...
June 15, 2015: Science of the Total Environment
#19
JOURNAL ARTICLE
Mônica Bolson, Sonia Marisa Hefler, Sonia Regina Hefler, Elisiane Inês Dall'Oglio Chaves, Arquimedes Gasparotto Junior, Euclides Lara Cardozo Junior
ETHNOPHARMACOLOGICAL RELEVANCE: This study aims to document the traditional knowledge on the use of medicinal plants in the neighborhood of the protected area "Parque Estadual da Cabeça do Cachorro", a fragment of seasonal semideciduous forests. This vegetation is intensely fragmented and disturbed; despite its importance there are few records of the traditional knowledge of medicinal species. MATERIAL AND METHODS: Twenty-four residents in the neighborhood of the protected area "Parque Estadual da Cabeça do Cachorro" were interviewed...
February 23, 2015: Journal of Ethnopharmacology
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JOURNAL ARTICLE
Y González-Castanedo, D Sanchez-Rodas, A M Sánchez de la Campa, M Pandolfi, A Alastuey, V E Cachorro, X Querol, J D de la Rosa
Sampling and chemical analyses, including major compounds and trace elements, of atmospheric particulate matter (PM10 and PM2.5) have been performed during 2006-2007 in a regional background monitoring station located within the Doñana Natural Park (SW of Spain). This region is strategic for air quality and climate change studies, representing a meeting place of the European and African continents, and the Atlantic Ocean and Mediterranean Sea. The present study based on meteorological parameters demonstrated long-range transport and impact of industrial plumes on the Doñana Natural...
January 2015: Chemosphere
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