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Parkinson's disease

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https://www.readbyqxmd.com/read/28750492/parkinson-disease-related-cortical-and-striatal-cognitive-patterns-in-dual-time-f-18-fp-cit-evidence-for-neural-correlates-between-the-caudate-and-the-frontal-lobe
#1
Hye J Son, Young J Jeong, Hyun J Yoon, Jae W Kim, Go-E Choi, Jong H Park, Do-Y Kang
BACKGROUND: Using dual time F-18 FP-CIT, we evaluated cortical perfusion, striatal binding and neuropsychological performance simultaneously in Parkinson's disease (PD) with and without mild cognitive impairment (MCI), to investigate neural correlates between caudate and frontal cortex. METHODS: According to the neuropsychological scores, subjects were classified into 26 healthy controls (HC), 38 PD-MCI (executive) (PE), 24 PD-MCI (non-executive) (PN) and 21 PD (motor) (PM)...
July 27, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28749970/effectiveness-of-physical-activity-on-patients-with-depression-and-parkinson-s-disease-a-systematic-review
#2
Pei-Ling Wu, Megan Lee, Tzu-Ting Huang
AIM: In this paper we aimed to systematically review the literature on physical activity's effect on depressive symptoms in Parkinson disease. BACKGROUND: Depression is a common symptom of Parkinson's disease and is associated with increased disability, rapid progression of motor symptoms, mortality, and adverse effects on Quality of Life. DESIGN: A systematic review of primary research was undertaken and conducted according to the Preferred Reporting Items for Systematic Reviews...
2017: PloS One
https://www.readbyqxmd.com/read/28749816/associations-of-rs823128-rs1572931-and-rs823156-polymorphisms-with-reduced-parkinson-s-disease-risks
#3
Ye Bai, Lihong Dong, Xinghua Huang, Shuanglin Zheng, Ping Qiu, Fenghua Lan
The PARK16 locus is considered to play a protective role in Parkinson's disease (PD). However, the epidemiological evidence on the relationships between PARK16 single-nucleotide polymorphisms (rs823128, rs1572931, and rs823156) and PD is inconsistent. Therefore, we carried out a meta-analysis to validate the relationships and performed a bioinformatic analysis to explore putative regulation mechanisms of the single-nucleotide polymorphisms in PD. Through meta-analysis, we confirmed that minor variants of rs823128A>G, rs1572931C>T, and rs823156A>G played protective roles in PD...
July 26, 2017: Neuroreport
https://www.readbyqxmd.com/read/28749580/dopamine-transporter-neuroimaging-as-an-enrichment-biomarker-in-early-parkinson-s-disease-clinical-trials-a-disease-progression-modeling-analysis
#4
Daniela J Conrado, Timothy Nicholas, Kuenhi Tsai, Sreeraj Macha, Vikram Sinha, Julie Stone, Brian Corrigan, Massimo Bani, Pierandrea Muglia, Ian A Watson, Volker D Kern, Elena Sheveleva, Kenneth Marek, Diane T Stephenson, Klaus Romero
Given the recognition that disease-modifying therapies should focus on earlier Parkinson's disease stages, trial enrollment based purely on clinical criteria poses significant challenges. The goal herein was to determine the utility of dopamine transporter neuroimaging as an enrichment biomarker in early motor Parkinson's disease clinical trials. Patient-level longitudinal data of 672 subjects with early-stage Parkinson's disease in the Parkinson's Progression Markers Initiative (PPMI) observational study and the Parkinson Research Examination of CEP-1347 Trial (PRECEPT) clinical trial were utilized in a linear mixed-effects model analysis...
July 27, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28748860/current-nondopaminergic-therapeutic-options-for-motor-symptoms-of-parkinson-s-disease
#5
REVIEW
Juan-Juan Du, Sheng-Di Chen
OBJECTIVE: The aim of this study was to summarize recent studies on nondopaminergic options for the treatment of motor symptoms in Parkinson's disease (PD). DATA SOURCES: Papers in English published in PubMed, Cochrane, and Ovid Nursing databases between January 1988 and November 2016 were searched using the following keywords: PD, nondopaminergic therapy, adenosine, glutamatergic, adrenergic, serotoninergic, histaminic, and iron chelator. We also reviewed the ongoing clinical trials in the website of clinicaltrials...
August 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28748763/induced-pluripotent-stem-cell-technology-a-paradigm-shift-in-medical-science-for-drug-screening-and-disease-modeling
#6
Meera Nair, Sardul Singh Sandhu, Anil Kumar Sharma
BACKGROUND: Induced Pluripotent Stem Cell (IPSC) Technology is the most advanced research as it offers an attractive alternative for establishing patient-specific IPSCs to recapitulate phenotypes of not only monogenic diseases (viz. Thalassaemia, Sickle cell anemia, Haemophilia, Tay-Sachs disease), but also late-onset polygenic diseases (viz. Parkinson's disease, Alzheimer's disease, schizophrenia). Over the hindsight, numerous studies of the past and current scientists have led to the production, maturation and understanding of induced pluripotent stem cell technology and its use in basic and clinical research...
July 27, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28748683/erratum-to-the-kmds-nation-study-korean-movement-disorders-society-multicenter-assessment-of-non-motor-symptoms-and-quality-of-life-in-parkinson-s-disease-nation-study-group
#7
Do Young Kwon, Seong Beom Koh, Jae Hyeok Lee, Hee Kyung Park, Han Joon Kim, Hae Won Shin, Jinyoung Youn, Kun Woo Park, Sun Ah Choi, Sang Jin Kim, Seong Min Choi, Ji Yun Park, Beom S Jeon, Ji Young Kim, Sun Ju Chung, Chong Sik Lee, Jeong Ho Park, Tae Beom Ahn, Won Chan Kim, Hyun Sook Kim, Sang Myung Cheon, Hee Tae Kim, Jee Young Lee, Ji Sun Kim, Eun Joo Kim, Jong Min Kim, Kwang Soo Lee, Joong Seok Kim, Min Jeong Kim, Jong Sam Baik, Ki Jong Park, Hee Jin Kim, Mee Young Park, Ji Hoon Kang, Sook Kun Song, Yong Duk Kim, Ji Young Yun, Ho Won Lee, Hyung Geun Oh, Jinwhan Cho, In Uk Song, Young H Sohn, Phil Hyu Lee, Jae Woo Kim
This corrects the article on p. 393 in vol. 12, PMID: 27819413.
July 2017: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/28748676/relationship-between-erectile-dysfunction-comorbidity-and-parkinson-s-disease-evidence-from-a-population-based-longitudinal-study
#8
Yuwan Yang, Hsinho Liu, Tienhuang Lin, Yuhung Kuo, Tengfu Hsieh
BACKGROUND AND PURPOSE: To determine the risk of Parkinson's disease (PD) in relation to erectile dysfunction (ED) based on the National Health Insurance Research Database in Taiwan. METHODS: We identified 3,153 patients who were newly diagnosed with ED between January 1, 2004 and December 31, 2010. A total of 12,612 randomly selected people without ED served as healthy controls. All of the study subjects were followed-up from the index date to the date of PD diagnosis, withdrawal from the National Health Insurance program, or the end of 2012 whichever occurred first...
July 2017: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/28748674/prognosis-of-patients-with-behavioral-variant-frontotemporal-dementia-who-have-focal-versus-diffuse-frontal-atrophy
#9
Jin San Lee, Na Yeon Jung, Young Kyoung Jang, Hee Jin Kim, Sang Won Seo, Juyoun Lee, Yeo Jin Kim, Jae Hong Lee, Byeong C Kim, Kyung Won Park, Soo Jin Yoon, Jee H Jeong, Sang Yun Kim, Seung Hyun Kim, Eun Joo Kim, Key Chung Park, David S Knopman, Duk L Na
BACKGROUND AND PURPOSE: Only a few studies have investigated the relationship between different subtypes and disease progression or prognosis in patients with behavioral variant frontotemporal dementia (bvFTD). Since a localized injury often produces more focal signs than a diffuse injury, we hypothesized that the clinical characteristics differ between patients with bvFTD who show diffuse frontal lobe atrophy (D-type) on axial magnetic resonance imaging (MRI) scans versus those with focal or circumscribed frontal lobe atrophy (F-type)...
July 2017: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/28748275/head-trauma-and-parkinson-s-disease-results-from-an-italian-case-control-study
#10
Alessandra Nicoletti, Rosario Vasta, Giovanni Mostile, Giuseppe Nicoletti, Gennarina Arabia, Giovanni Iliceto, Paolo Lamberti, Roberto Marconi, Letterio Morgante, Paolo Barone, Aldo Quattrone, Mario Zappia
We evaluated the possible association between head trauma and Parkinson's disease (PD). The FRAGAMP (Fattori di Rischio Ambientali e Genetici Associati alla Malattia di Parkinson) study is a large Italian multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in PD. Cases and controls were enrolled from six movement disorders centers located in the Central-Southern Italy. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data...
July 26, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28748036/comorbidity-of-periodontal-disease-two-sides-of-the-same-coin-an-introduction-for-the-clinician
#11
REVIEW
Palle Holmstrup, Christian Damgaard, Ingar Olsen, Björn Klinge, Allan Flyvbjerg, Claus Henrik Nielsen, Peter Riis Hansen
Increasing evidence has suggested an independent association between periodontitis and a range of comorbidities, for example cardiovascular disease, type 2 diabetes, rheumatoid arthritis, osteoporosis, Parkinson's disease, Alzheimer's disease, psoriasis, and respiratory infections. Shared inflammatory pathways are likely to contribute to this association, but distinct causal mechanisms remain to be defined. Some of these comorbid conditions may improve by periodontal treatment, and a bidirectional relationship may exist, where, for example, treatment of diabetes can improve periodontal status...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/28747776/animal-models-of-%C3%AE-synucleinopathy-for-parkinson-disease-drug-development
#12
REVIEW
James B Koprich, Lorraine V Kalia, Jonathan M Brotchie
A major challenge in Parkinson disease (PD) will be to turn an emerging and expanding pipeline of novel disease-modifying candidate compounds into therapeutics. Novel targets need in vivo validation, and candidate therapeutics require appropriate preclinical platforms on which to define potential efficacy and target engagement before advancement to clinical development. We propose that α-synuclein (α-syn)-based mammalian models will be crucial for this process. Here, we review α-syn transgenic mouse models, viral vector models of α-syn overexpression and models of 'prion-like' spread of α-syn, and describe how each of these model types may contribute to PD drug discovery...
July 13, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28747452/mri-guided-focused-ultrasound-thalamotomy-in-non-et-tremor-syndromes
#13
Alfonso Fasano, Maheleth Llinas, Renato P Munhoz, Eugen Hlasny, Walter Kucharczyk, Andres M Lozano
OBJECTIVE: To report the 6-month single-blinded results of unilateral thalamotomy with MRI-guided focused ultrasound (MRgFUS) in patients with tremors other than essential tremor. METHODS: Three patients with tremor due to Parkinson disease, 2 with dystonic tremor in the context of cervicobrachial dystonia and writer's cramp, and 1 with dystonia gene-associated tremor underwent MRgFUS targeting the ventro-intermedius nucleus (Vim) of the dominant hemisphere. The primary endpoint was the reduction of lateralized items of the Tremor Rating Scale of contralateral hemibody assessed by a blinded rater...
July 26, 2017: Neurology
https://www.readbyqxmd.com/read/28747449/loss-of-cutaneous-large-and-small-fibers-in-naive-and-l-dopa-treated-pd-patients
#14
Maria Nolano, Vincenzo Provitera, Fiore Manganelli, Rosa Iodice, Annamaria Stancanelli, Giuseppe Caporaso, Annamaria Saltalamacchia, Francesca Califano, Bernardo Lanzillo, Marina Picillo, Paolo Barone, Lucio Santoro
OBJECTIVE: To study small and large fiber pathology in drug-naive and l-dopa-treated patients affected by Parkinson disease (PD) in early phases, before the occurrence of neuropathic electrophysiologic abnormalities. METHODS: We enrolled 85 patients with idiopathic PD (male/female 49/36, age 61.3 ± 9.7 years) without electrophysiologic signs of neuropathy, including 48 participants naive to l-dopa treatment. All patients underwent clinical, functional, and morphologic assessment of sensory and autonomic nerves through dedicated questionnaires, quantitative sensory testing, sympathetic skin response, dynamic sweat test, and punch biopsies from glabrous and hairy skin...
July 26, 2017: Neurology
https://www.readbyqxmd.com/read/28747283/a-case-of-lamellar-ichthyosis-due-to-a-novel-tgm1-mutation-associated-with-parkinson-s-disease
#15
Runa Morita-Adachi, Takuya Takeichi, Yusuke Okuno, Shinsuke Kataoka, Shimpei Hoshino, Masashi Akiyama
No abstract text is available yet for this article.
July 27, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28747279/portable-objective-assessment-of-upper-extremity-motor-function-in-parkinson-s-disease
#16
L M Chahine, L Uribe, P Hogarth, J McNames, A Siderowf, K Marek, D Jennings
INTRODUCTION: Objective, portable measures of motor function for out-of-office assessments are needed in Parkinson's Disease (PD). This study had 3 objectives. First, to examine change in objective motor measurements in PD (as assessed with the Objective PD Measurement (OPDM) system). Second, to correlate objective measures with clinical features and putative PD cerebrospinal fluid (CSF) and dopaminergic imaging biomarkers. Third, to assess participant compliance with and perceptions of serial in-home motor assessments...
July 19, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28747137/modified-pfeffer-questionnaire-for-functional-assessment-in-parkinson-disease
#17
Kelson James Almeida, Lívio Pereira de Macêdo, Janine Lemos de Melo Lobo Jofili Lopes, Edson Bor-Seng-Shu, Raimundo Nonato Campos-Sousa, Egberto Reis Barbosa
INTRODUCTION: It was proposed to modify the Pfeffer questionnaire (PQ) for functional assessment in patients with Parkinson disease (PD). AIM: To determine the cutoff score for diagnosis of functional impairment in patients with PD by modified PQ (mPQ). METHODS: A total of 110 patients with PD were enrolled into the study, and a neuropsychological test battery was performed to assess their cognitive status. Regarding functional assessment, the mPQ has been applied, and their results were compared to the functional assessment by Informant Questionnaire on Cognitive Decline in the Elderly adapted for use in Brazil (IQCODE-BR)...
January 1, 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28747135/high-burden-and-depression-among-late-stage-idiopathic-parkinson-disease-and-progressive-supranuclear-palsy-caregivers
#18
Christian Schmotz, Carmen Richinger, Stefan Lorenzl
OBJECTIVES: Caregivers of patients with late-stage idiopathic Parkinson disease (IPD) and late-stage progressive supranuclear palsy (PSP) often suffer from severe psychological strain themselves. This study investigates the influence of the different kind of symptoms in IPD and PSP on the psychological burden of the caregivers. METHODS: Twenty patients with late-stage IPD and 20 patients with late-stage PSP and their caregivers were investigated. To measure the degree of motor, cognitive, and affective impairment of the patients, the instruments Subscale III of the Unified Rating Scale for Parkinsonism (UPDRS-III), a shortened 24-item version of the Mini-Mental State Examination, and the Geriatric Depression Scale (GDS-30) were used...
January 1, 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28746937/prevalence-duration-and-severity-of-parkinson-s-disease-in-germany-a-combined-meta-analysis-from-literature-data-and-outpatient-samples
#19
Dirk Enders, Monika Balzer-Geldsetzer, Oliver Riedel, Richard Dodel, Hans-Ulrich Wittchen, Sven-Christian Sensken, Björn Wolff, Jens-Peter Reese
BACKGROUND: Epidemiological data on the prevalence of Parkinson's disease (PD) in Germany are limited. The aims of this study were to estimate the age- and gender-specific prevalence of PD in Germany as well as the severity and illness duration. SUMMARY: A systematic literature search was performed in 5 different databases. European studies were included if they reported age- and gender-specific numbers of prevalence rates of PD. Meta-analytic approaches were applied to derive age- and gender-specific pooled prevalence estimates...
July 27, 2017: European Neurology
https://www.readbyqxmd.com/read/28746897/parkinsonian-features-in-aging-gfap-hmox1-transgenic-mice-overexpressing-human-ho-1-in-the-astroglial-compartment
#20
Wei Song, Marisa Cressatti, Hillel Zukor, Adrienne Liberman, Carmela Galindez, Hyman M Schipper
Epigenetic influences mediating brain iron deposition, oxidative mitochondrial injury, and macroautophagy in Parkinson disease and related conditions remain enigmatic. Here, we show that selective overexpression of the stress protein, heme oxygenase-1 (HO-1) in astrocytes of GFAP.HMOX1 transgenic mice between 8.5 and 19 months of age results in nigrostriatal hypodopaminergia associated with locomotor incoordination and stereotypy; downregulation of tyrosine hydroxylase, DAT, LMX1B, Nurr1, Pitx3 and DJ-1 mRNA and/or protein; overproduction of α-synuclein and ubiquitin; oxidative stress; basal ganglia siderosis; mitochondrial damage/mitophagy; and augmented GABAergic systems (increased GABA, GAD67 and reelin)...
June 28, 2017: Neurobiology of Aging
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