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https://www.readbyqxmd.com/read/28329658/potential-relationship-between-rosacea-and-parkinson-s-disease
#1
Erin Ibler, Beatrice Nardone, Sara Majewski, Nicholas Guido, Thy Huynh, Sarah Lyon, Stephanie M Rangel, Bethanee Schlosser, Dennis P West, Anne E Laumann
Rosacea is a common inflammatory condition characterized by transient or persistent facial erythema, telangiectasias, papules and pustules, for which an association has been reported to exist with Parkinson's disease (PD). We used a large, urban, single center, electronic medical record repository by searching the Northwestern Medicine Enterprise Data Warehouse (NMEDW) (> 4 million patients) for this association. Patients were included if they had an in-person encounter (Jan 2001 to May 2016) and with 1 year documentation of follow-up...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329332/excessive-daytime-sleepiness-predicts-neurodegeneration-in-idiopathic-rem-sleep-behavior-disorder
#2
Junying Zhou, Jihui Zhang, Siu Ping Lam, Joey Wy Chan, Vincent Mok, Anne Chan, Shirley Xin Li, Yaping Liu, Xiangdong Tang, Wing Ho Yung, Yun Kwok Wing
Study Objectives: To determine the association of excessive daytime sleepiness (EDS) with the conversion of neurodegenerative diseases in patients with idiopathic REM sleep behavior disorder (iRBD). Methods: A total of 179 patients with iRBD (79.1% males, mean age = 66.3 ± 9.8 years) were consecutively recruited. Forty-five patients with Epworth Sleepiness Scale score ≥ 14 were defined as having EDS. Demographic, clinical and polysomnographic data were compared between iRBD patients with and without EDS...
March 16, 2017: Sleep
https://www.readbyqxmd.com/read/28329183/remote-traumatic-brain-injury-is-associated-with-motor-dysfunction-in-older-military-veterans
#3
Raquel C Gardner, Carrie B Peltz, Kimbra Kenney, Kenneth E Covinsky, Ramon Diaz-Arrastia, Kristine Yaffe
Background: Traumatic brain injury (TBI) has been identified as a risk factor for Parkinson's disease (PD). Motor dysfunction among TBI-exposed elders without PD has not been well characterized. We sought to determine whether remote TBI is a risk factor for motor dysfunction on exam and functionally relevant motor dysfunction in day-to-day life among independently living elders without PD. Methods: This is a cross-sectional cohort study of independently living retired military veterans aged 50 or older with (n = 78) and without (n = 85) prior TBI-all without diagnosed PD...
January 20, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28329031/who-take-naps-self-reported-and-objectively-measured-napping-in-very-old-women
#4
Yue Leng, Katie Stone, Sonia Ancoli-Israel, Kenneth Covinsky, Kristine Yaffe
Background: Despite the widespread belief that napping is common among older adults, little is known about the correlates of napping. We examined the prevalence and correlates of self-reported and objectively measured napping among very old women. Methods: We studied 2,675 community-dwelling women (mean age 84.5 ± 3.7 years; range 79-96). Self-reported napping was defined as a report of regular napping for ≥1 hour per day. Individual objective naps were defined as ≥5 consecutive minutes of inactivity as measured by actigraphy and women were characterized as "objective nappers" if they had at least 60 minutes of naps per day...
February 18, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28328577/parkinson-s-disease-and-musculoskeletal-pain-an-8-year-population-based-cohort-study
#5
Wei-Hung Lien, Wei-Chih Lien, Ta-Shen Kuan, Shang-Te Wu, Yi-Ting Chen, Ching-Ju Chiu
The aim of the present study was to evaluate the incidence and clinical features of musculoskeletal pain (MSP) in patients with Parkinson's disease (PD) compared to a control group without the disease. The retrospective cohort study used a subset of the Taiwan National Health Insurance Research Database (NHIRD) comprising information on one million beneficiaries randomly sampled from the entire population of Taiwan. A total of 490 patients aged 50 and above with newly diagnosed Parkinson's disease were identified during a period from 2000-2005...
March 21, 2017: Pain
https://www.readbyqxmd.com/read/28328536/neurotransmission-systems-in-parkinson-s-disease
#6
Hossein Sanjari Moghaddam, Ameneh Zare-Shahabadi, Farzaneh Rahmani, Nima Rezaei
Parkinson's disease (PD) is histologically characterized by the accumulation of α-synuclein particles, known as Lewy bodies. The second most common neurodegenerative disorder, PD is widely known because of the typical motor manifestations of active tremor, rigidity, and postural instability, while several prodromal non-motor symptoms including REM sleep behavior disorders, depression, autonomic disturbances, and cognitive decline are being more extensively recognized. Motor symptoms most commonly arise from synucleinopathy of nigrostriatal pathway...
March 22, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28328168/intrastriatal-transplantation-of-human-neural-stem-cells-restores-the-impaired-subventricular-zone-in-parkinsonian-mice
#7
Fuxing Zuo, Feng Xiong, Xia Wang, Xueyuan Li, Renzhi Wang, Wei Ge, Xinjie Bao
Cell replacement therapy using neural stem cells (NSCs) transplantation has recently emerged as a promising method of Parkinson's disease (PD) treatment; however, the underlying mechanisms are not fully understood. To gain new insights into the mechanisms of 6-hydroxydopamine (6-OHDA)-induced lesioning and therapeutic efficacy of human NSCs (hNSCs) transplantation, the striatum (ST) of intrastriatal 6-OHDA-injected parkinsonian mice were unilaterally engrafted with undifferentiated hNSCs. A high-throughput quantitative proteomic approach was used to characterize the proteome profiles of PD-related brain regions such as the SN, ST, olfactory bulb (OB), and subventricular zone (SVZ) in these mice...
March 22, 2017: Stem Cells
https://www.readbyqxmd.com/read/28327916/multilayer-modeling-and-analysis-of-human-brain-networks
#8
Manlio De Domenico
Understanding how the human brain is structured, and how its architecture is related to the function, is of paramount importance for a variety of applications, including, but not limited to, new ways to prevent, deal with and cure brain diseases, such as Alzheimer's or Parkinson's, and psychiatric disorders, such as Schizophrenia. The recent advances in structural and functional neuroimaging, together with the increasing attitude to interdisciplinary approaches involving computer science, mathematics and physics, are fostering interesting results from computational neuroscience, that are quite often based on the analysis of complex network representation of human brain...
February 6, 2017: GigaScience
https://www.readbyqxmd.com/read/28327909/clinical-outcomes-following-surgical-management-of-coexisting-parkinson-disease-and-cervical-spondylotic-myelopathy
#9
Roy Xiao, Jacob A Miller, Daniel Lubelski, Thomas E Mroz, Edward C Benzel, Ajit A Krishnaney, Andre Machado
BACKGROUND: Distinguishing the causes of weakness and gait instability in patients with Parkinson disease (PD) and cervical spondylotic myelopathy (CSM) is a diagnostic and therapeutic challenge due to symptomatic similarities. No study has reported outcomes following decompression in patients with PD and CSM. OBJECTIVE: To report outcomes following cervical decompression for patients with coexisting PD and CSM. METHODS: A retrospective matched cohort study of all patients with PD and CSM undergoing cervical decompression at a tertiary-care center between January 1996 and December 2014 was conducted...
February 2, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28327638/conditional-deletion-of-ndufs4-in-dopaminergic-neurons-promotes-parkinson-s-disease-like-non-motor-symptoms-without-loss-of-dopamine-neurons
#10
Won-Seok Choi, Hyung-Wook Kim, François Tronche, Richard D Palmiter, Daniel R Storm, Zhengui Xia
Reduction of mitochondrial complex I activity is one of the major hypotheses for dopaminergic neuron death in Parkinson's disease. However, reduction of complex I activity in all cells or selectively in dopaminergic neurons via conditional deletion of the Ndufs4 gene, a subunit of the mitochondrial complex I, does not cause dopaminergic neuron death or motor impairment. Here, we investigated the effect of reduced complex I activity on non-motor symptoms associated with Parkinson's disease using conditional knockout (cKO) mice in which Ndufs4 was selectively deleted in dopaminergic neurons (Ndufs4 cKO)...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327632/assessment-of-residential-environmental-exposure-to-pesticides-from-agricultural-fields-in-the-netherlands
#11
Maartje Brouwer, Hans Kromhout, Roel Vermeulen, Jan Duyzer, Henk Kramer, Gerard Hazeu, Geert de Snoo, Anke Huss
We developed a spatio-temporal model for the Netherlands to estimate environmental exposure to individual agricultural pesticides at the residential address for application in a national case-control study on Parkinson's disease (PD). Data on agricultural land use and pesticide use were combined to estimate environmental exposure to pesticides for the period 1961 onwards. Distance categories of 0-50 m, >50-100 m, >100-500 m and >500-1000 m around residences were considered. For illustration purposes, exposure was estimated for the control population (n=607) in the PD case-control study...
March 22, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28326933/attenuation-of-hyperalgesia-responses-via-the-modulation-of-5-hydroxytryptamine-signalings-in-the-rostral-ventromedial-medulla-and-spinal-cord-in-a-6-hydroxydopamine-induced-rat-model-of-parkinson-s-disease
#12
Chen-Tao Wang, Cheng-Jie Mao, Xiao-Qi Zhang, Cai-Yi Zhang, Dong-Jun Lv, Ya-Ping Yang, Kai-Lin Xia, Jun-Yi Liu, Fen Wang, Li-Fang Hu, Guang-Yin Xu, Chun-Feng Liu
Background Although pain is one of the most distressing non-motor symptoms among patients with Parkinson's disease, the underlying mechanisms of pain in Parkinson's disease remain elusive. The aim of the present study was to investigate the role of serotonin (5-hydroxytryptamine) in the rostral ventromedial medulla (RVM) and spinal cord in pain sensory abnormalities in a 6-hydroxydopamine-treated rat model of Parkinson's disease. Methods The rotarod test was used to evaluate motor function. The radiant heat test and von Frey test were conducted to evaluate thermal and mechanical pain thresholds, respectively...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28326670/validation-of-an-informant-based-cognitive-screening-tool-for-parkinson-disease
#13
Kok-Yoon Chee, Kheng-Yee Ong, Chin-Yeat Mak, Sapini Yacob, Shen-Cheng Yeo, Nathisha Thrichelam, Deepa Darshini Amarnath, Kai-Shin Thong, Chee-Hoong Moey, Thanam Ponusamy, Shanthi Viswanathan, Santhi Puvanarajah
INTRODUCTION: The objective of this study was to establish the psychometric properties of the AD8 Dementia Screening Interview in patients with Parkinson disease (PD) with or without cognitive impairment using the Montreal Cognitive Assessment Tool (MoCA) for comparison. METHODS: The AD8 was translated into Malay for Malay-speaking participants. A correlation analysis and a receiver operator characteristic curve were generated to establish the psychometric properties of the AD8 in relation to the MoCA...
March 21, 2017: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
https://www.readbyqxmd.com/read/28326445/the-role-of-nonhuman-primate-models-in-the-development-of-cell-based-therapies-for-parkinson-s-disease
#14
REVIEW
Scott C Vermilyea, Marina E Emborg
Through the course of over three decades, nonhuman primate (NHP) studies on cell-based therapies (CBTs) for Parkinson's disease (PD) have provided insight into the feasibility, safety and efficacy of the approach, methods of cell collection and preparation, cell viability, as well as potential brain targets. Today, NHP research continues to be a vital source of information for improving cell grafts and analyzing how the host affects graft survival, integration and function. Overall, this article aims to discuss the role that NHP models of PD have played in CBT development and highlights specific issues that need to be considered to maximize the value of NHP studies for the successful clinical translation of CBTs...
March 22, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28326165/neurochemical-and-motor-changes-in-mice-with-combined-mutations-linked-to-parkinson-s-disease
#15
Xiang Bai, Margaret Chia-Ying Wey, Paul Anthony Martinez, Chao Shi, Elizabeth Fernandez, Randy Strong
Considerable evidence suggests that oxidative stress plays a role in the pathogenesis of Parkinson's disease (PD), the most prevalent neurodegenerative movement disorder. Reduced expression of aldehyde dehydrogenase-1 (ALDH1) and glutathione peroxidase-1 (GPX1), enzymes that function to detoxify aldehydes and hydroxyl radicals, respectively, has been reported in the substantia nigra of patients who died with PD. To determine whether deficiency in these two genes contributes to the pathogenesis of PD, mice were generated with homozygous null mutations of both Aldh1a1 (the murine homolog of ALDH1) and Gpx1 genes [knockout (KO) mice]...
2017: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/28326036/associations-between-early-markers-of-parkinson-s-disease-and-sarcopenia
#16
Michael Drey, Sandra E Hasmann, Jan-Peter Krenovsky, Markus A Hobert, Stefanie Straub, Morad Elshehabi, Anna-Katharina von Thaler, Andreas J Fallgatter, Gerhard W Eschweiler, Ulrike Suenkel, Daniela Berg, Walter Maetzler
Introduction: Sarcopenia and Parkinson's disease (PD) are both common age-related syndromes, and there is preliminary evidence that the probability of the co-occurrence of these syndromes within one individual is higher than expected. However, it is unclear to date whether one of the syndromes induces the other, or whether there may be common underlying causes. This pilot study thus aimed at investigating the association of the features of increased risk for PD with early stage sarcopenia (ESS). Method: Two hundred and fifty-five community-dwelling individuals were recruited from the Tübinger evaluation of Risk factors for Early detection of NeuroDegeneration (TREND) study...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28326029/beta-oscillatory-changes-and-retention-of-motor-skills-during-practice-in-healthy-subjects-and-in-patients-with-parkinson-s-disease
#17
Aaron B Nelson, Clara Moisello, Jing Lin, Priya Panday, Serena Ricci, Andrea Canessa, Alessandro Di Rocco, Angelo Quartarone, Giuseppe Frazzitta, Ioannis U Isaias, Giulio Tononi, Chiara Cirelli, M Felice Ghilardi
Recently we found that modulation depth of beta power during movement increases with practice over sensory-motor areas in normal subjects but not in patients with Parkinson's disease (PD). As such changes might reflect use-dependent modifications, we concluded that reduction of beta enhancement in PD represents saturation of cortical plasticity. A few questions remained open: What is the relation between these EEG changes and retention of motor skills? Would a second task exposure restore beta modulation enhancement in PD? Do practice-induced increases of beta modulation occur within each block? We thus recorded EEG in patients with PD and age-matched controls in two consecutive days during a 40-min reaching task divided in fifteen blocks of 56 movements each...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28326021/abnormalities-in-structural-covariance-of-cortical-gyrification-in-parkinson-s-disease
#18
Jinping Xu, Jiuquan Zhang, Jinlei Zhang, Yue Wang, Yanling Zhang, Jian Wang, Guanglin Li, Qingmao Hu, Yuanchao Zhang
Although abnormal cortical morphology and connectivity between brain regions (structural covariance) have been reported in Parkinson's disease (PD), the topological organizations of large-scale structural brain networks are still poorly understood. In this study, we investigated large-scale structural brain networks in a sample of 37 PD patients and 34 healthy controls (HC) by assessing the structural covariance of cortical gyrification with local gyrification index (lGI). We demonstrated prominent small-world properties of the structural brain networks for both groups...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28325755/loss-of-pink1-leads-to-metabolic-deficits-in-adult-neural-stem-cells-and-impedes-differentiation-of-newborn-neurons-in-the-mouse-hippocampus
#19
Sandeep Kumar Agnihotri, Ruifang Shen, Jihong Li, Xu Gao, Hansruedi Büeler
Emerging evidence suggests that mitochondrial dynamics regulates adult hippocampal neurogenesis (AHN). Although abnormal AHN has been linked to depression, anxiety, and cognitive dysfunction, which are features of neurodegenerative conditions, including Parkinson's disease (PD), the impact of mitochondrial deficits on AHN have not been explored previously in a model of neurodegeneration. Here, we used PTEN-induced kinase 1-deficient (PINK1(-/-) ) mice that lacked a mitochondrial kinase mutated in recessive familial PD...
March 21, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28325615/association-among-type-d-personality-non-motor-symptoms-and-quality-of-life-in-parkinson-s-disease-a-cross-sectional-study
#20
Sung Reul Kim, Ji Young Kim, Hyun Kyung Kim, Kyeung Eun Lim, Mi Sun Kim, Sun Ju Chung
Patients with type D personality are vulnerable to stress, show poor prognosis in disease, and experience low quality of life. The aims of this study were to identify the associations among type D personality, non-motor symptoms, and quality of life in patients with Parkinson's disease (PD). Data were collected between May 28 and August 6, 2015 from a convenience sample of 196 PD patients. About 20% of participants were classified into the type D personality group. This group experienced statistically significantly higher non-motor symptoms and lower quality of life compared to the non-type D personality group...
March 18, 2017: Geriatric Nursing
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