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https://www.readbyqxmd.com/read/29676068/trpv1-blocking-alleviates-airway-inflammation-and-remodeling-in-a-chronic-asthma-murine-model
#1
Joon Young Choi, Hwa Young Lee, Jung Hur, Kyung Hoon Kim, Ji Young Kang, Chin Kook Rhee, Sook Young Lee
PURPOSE: Asthma is a chronic inflammatory airway disease characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. There is emerging interest in the involvement of the transient receptor potential vanilloid 1 (TRPV1) channel in the pathophysiology of asthma. This study examined whether TRPV1 antagonism alleviates asthma features in a murine model of chronic asthma. METHODS: BALB/c mice were sensitized to and challenged by ovalbumin to develop chronic asthma...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29676065/the-emerging-role-of-trpv1-in-airway-inflammation
#2
EDITORIAL
Joo Hee Kim
No abstract text is available yet for this article.
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29675059/natural-history-of-treatment-emergent-central-sleep-apnea-on-positive-airway-pressure-a-systematic-review
#3
Gaurav Nigam, Muhammad Riaz, Edward T Chang, Macario Camacho
INTRODUCTION: Treatment-emergent central sleep apnea (TECSA) is observed in some patients when they are treated with positive airway pressure (PAP) after significant resolution of the preexisting obstructive events in patients with obstructive sleep apnea. The objective of this study was to systematically review the literature for studies describing the natural history of TECSA. METHODS: PubMed, Medline, Scopus, Web of Science, and Cochran Library databases were searched through June 29, 2017...
April 2018: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/29674392/cholesterol-metabolism-promotes-b-cell-positioning-during-immune-pathogenesis-of-chronic-obstructive-pulmonary-disease
#4
Jie Jia, Thomas M Conlon, Rim Sj Sarker, Demet Taşdemir, Natalia F Smirnova, Barkha Srivastava, Stijn E Verleden, Gizem Güneş, Xiao Wu, Cornelia Prehn, Jiaqi Gao, Katharina Heinzelmann, Jutta Lintelmann, Martin Irmler, Stefan Pfeiffer, Michael Schloter, Ralf Zimmermann, Martin Hrabé de Angelis, Johannes Beckers, Jerzy Adamski, Hasan Bayram, Oliver Eickelberg, Ali Önder Yildirim
The development of chronic obstructive pulmonary disease (COPD) pathogenesis remains unclear, but emerging evidence supports a crucial role for inducible bronchus-associated lymphoid tissue (iBALT) in disease progression. Mechanisms underlying iBALT generation, particularly during chronic CS exposure, remain to be defined. Oxysterol metabolism of cholesterol is crucial to immune cell localization in secondary lymphoid tissue. Here, we demonstrate that oxysterols also critically regulate iBALT generation and the immune pathogenesis of COPD In both COPD patients and cigarette smoke (CS)-exposed mice, we identified significantly upregulated CH25H and CYP7B1 expression in airway epithelial cells, regulating CS-induced B-cell migration and iBALT formation...
April 19, 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29672600/associations-of-obesity-with-tracheal-intubation-success-on-first-attempt-and-adverse-events-in-the-emergency-department-an-analysis-of-the-multicenter-prospective-observational-study-in-japan
#5
Hiromasa Yakushiji, Tadahiro Goto, Wataru Shirasaka, Yusuke Hagiwara, Hiroko Watase, Hiroshi Okamoto, Kohei Hasegawa
Obesity is deemed to increase the risk of difficult tracheal intubation. However, there is a dearth of research that examines the relationship of obesity with intubation success and adverse events in the emergency department (ED). We analyzed the data from a prospective, observational, multicenter study-the Japanese Emergency Airway Network (JEAN) 2 study from 2012 through 2016. We included all adults (aged ≥18 years) who underwent tracheal intubation in the ED. Patients were categorized into three groups according to their body mass index (BMI): lean (<25...
2018: PloS One
https://www.readbyqxmd.com/read/29672533/protection-afforded-by-respirators-when-performing-endotracheal-intubation-using-a-direct-laryngoscope-glidescope%C3%A2-and-i-gel%C3%A2-device-a-randomized-trial
#6
Hyunggoo Kang, Yoonje Lee, Sanghyun Lee, Yeongtak Song, Tae Ho Lim, Jaehoon Oh, Juncheol Lee, Hyungoo Shin
Emergency physicians are at risk of infection during invasive procedures, and wearing a respirator can reduce this risk. The aim of this study was to determine whether the protection afforded by a respirator during intubation is affected by the type of airway device used. In this randomized crossover study, 26 emergency physicians underwent quantitative fit tests for a N95 respirator (cup-type or fold-type) before and during intubation with a direct laryngoscope, GlideScope®, or i-gel® airway device. The primary outcome was the fit factor value of the respirator and the secondary outcome was the level of acceptable protection provided (percentage of fit factor scores above 100)...
2018: PloS One
https://www.readbyqxmd.com/read/29671866/isocapnic-hyperventilation-provides-early-extubation-after-head-and-neck-surgery-a-prospective-randomized-trial
#7
K Hallén, P Jildenstål, O Stenqvist, J Oras, S-E Ricksten, S Lindgren
BACKGROUND: Isocapnic hyperventilation (IHV) shortens recovery time after inhalation anaesthesia by increasing ventilation while maintaining a normal airway carbon dioxide (CO2 )-level. One way of performing IHV is to infuse CO2 to the inspiratory limb of a breathing circuit during mechanical hyperventilation (HV). In a prospective randomized study, we compared this IHV technique to a standard emergence procedure (control). METHODS: Thirty-one adult ASA I-III patients undergoing long-duration (>3 hours) sevoflurane anaesthesia for major head and neck surgery were included and randomized to IHV-treatment (n = 16) or control (n = 15)...
April 19, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29669351/bronchial-thermoplasty-in-severe-asthma-best-practice-recommendations-from-an-expert-panel
#8
Peter I Bonta, Pascal Chanez, Jouke T Annema, Pallav L Shah, Robert Niven
Bronchial thermoplasty (BT) is a bronchoscopic treatment for patients with severe asthma who remain symptomatic despite optimal medical therapy. In this "expert best practice" paper, the background and practical aspects of BT are highlighted. Randomized, controlled clinical trials have shown BT to be safe and effective in reducing severe exacerbations, improving quality of life, and decreasing emergency department visits. Five-year follow-up studies have provided evidence of the functional stability of BT-treated patients with persistence of a clinical benefit...
April 17, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29666691/internal-laryngocele-unusual-onset-in-a-91-year-old-female-patient
#9
Maria C Spinosi, Chiara Mezzedimi, Giovanni Monciatti, Desiderio Passali
While internal laryngoceles rarely cause major clinical complaints, they may lead to airway obstruction and require emergency intervention on rare occasions. We report a 91-year-old patient who was referred to the Ear, Nose & Throat Clinic of the Policlinico Santa Maria alle Scotte, Siena, Italy, in 2017 due to recurrent episodes of severe dyspnoea. A flexible nasopharyngolaryngoscopic examination revealed an internal laryngocele of approximately 1.5 cm in diameter that moved up and down the glottic plane, occasionally invading the subglottic space during inspiration and impeding airflow...
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29661406/pre-hospital-anaesthesia-no-longer-the-poor-relative-of-high-quality-in-hospital-emergency-airway-management
#10
EDITORIAL
D J Lockey, K Crewdson
No abstract text is available yet for this article.
May 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29657097/single-cell-transcriptomic-profiling-of-pluripotent-stem-cell-derived-scgb3a2-airway-epithelium
#11
Katherine B McCauley, Konstantinos-Dionysios Alysandratos, Anjali Jacob, Finn Hawkins, Ignacio S Caballero, Marall Vedaie, Wenli Yang, Katherine J Slovik, Michael Morley, Gianni Carraro, Seunghyi Kook, Susan H Guttentag, Barry R Stripp, Edward E Morrisey, Darrell N Kotton
Lung epithelial lineages have been difficult to maintain in pure form in vitro, and lineage-specific reporters have proven invaluable for monitoring their emergence from cultured pluripotent stem cells (PSCs). However, reporter constructs for tracking proximal airway lineages generated from PSCs have not been previously available, limiting the characterization of these cells. Here, we engineer mouse and human PSC lines carrying airway secretory lineage reporters that facilitate the tracking, purification, and profiling of this lung subtype...
April 9, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29656528/the-role-of-scalpel-bougie-cricothyroidotomy-in-managing-emergency-front-of-neck-airway-access-a-review-and-technical-update-for-ent-surgeons
#12
N D McNiven, J P Pracy, B A McGrath, A K Robson
In October 2016 an editorial was published jointly in Clinical Otolaryngology and the British Journal of Anaesthesia concerning the appropriate management of the difficult airway in a situation of 'Can't Intubate Can't Oxygenate' (CICO).1 It highlighted the importance of joint working between surgeons and anaesthetists and also made a case for the wider use of the scalpel-bougie cricothyroidotomy technique in securing a Front of Neck Airway (FONA), especially in an emergency. This article is protected by copyright...
April 15, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29652577/lung-cancers-associated-with-cystic-airspaces-underrecognized-features-of-early-disease
#13
Sarah Sheard, Joanna Moser, Charlie Sayer, Konstantinos Stefanidis, Anand Devaraj, Ioannis Vlahos
Early lung cancers associated with cystic airspaces are increasingly being recognized as a cause of delayed diagnoses-owing to data gathered from screening trials and encounters in routine clinical practice as more patients undergo serial imaging. Several morphologic subtypes of cancers associated with cystic airspaces exist and can exhibit variable patterns of progression as the solid elements of the tumor grow. Current understanding of the pathogenesis of these malignancies is limited, and the numbers of cases reported in the literature are small...
April 13, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29651869/new-mesh-type-phantoms-and-their-dosimetric-applications-including-emergencies
#14
C H Kim, Y S Yeom, T T Nguyen, M C Han, C Choi, H Lee, H Han, B Shin, J-K Lee, H S Kim, M Zankl, N Petoussi-Henss, W E Bolch, C Lee, B S Chung, R Qiu, K Eckerman
Committee 2 of the International Commission on Radiological Protection (ICRP) has constructed mesh-type adult reference computational phantoms by converting the voxel-type ICRP Publication 110 adult reference computational phantoms to a high-quality mesh format, and adding those tissues that were below the image resolution of the voxel phantoms and therefore not included in the Publication 110 phantoms. The new mesh phantoms include all the necessary source and target tissues for effective dose calculations, including the 8-40-µm-thick target layers of the alimentary and respiratory tract organs, thereby obviating the need for supplemental organ-specific stylised models (e...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29651626/current-topics-in-the-management-of-acute-traumatic-spinal-cord-injury
#15
Christopher D Shank, Beverly C Walters, Mark N Hadley
Acute traumatic spinal cord injury (SCI) affects more than 250,000 people in the USA, with approximately 17,000 new cases each year. It continues to be one of the most significant causes of trauma-related morbidity and mortality. Despite the introduction of primary injury prevention education and vehicle safety devices, such as airbags and passive restraint systems, traumatic SCI continues to have a substantial impact on the healthcare system. Over the last three decades, there have been considerable advancements in the management of patients with traumatic SCI...
April 12, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29644546/imaging-of-urgencies-and-emergencies-in-the-lung-cancer-patient
#16
REVIEW
Bruno De Potter, Jef Huyskens, Birgitta Hiddinga, Maarten Spinhoven, Annelies Janssens, Jan P van Meerbeeck, Paul M Parizel, Annemie Snoeckx
Lung cancer patients often experience potentially life-threatening medical urgencies and emergencies, which may be a direct or indirect result of the underlying malignancy. This pictorial review addresses the most common thoracic, neurological and musculoskeletal medical emergencies in lung cancer patients, including superior vena cava syndrome, pulmonary embolism, spontaneous pneumothorax, cardiac tamponade, massive haemoptysis, central airway obstruction, oesophagorespiratory fistula, malignant spinal cord compression, carcinomatous meningitis, cerebral herniation and pathological fracture...
April 11, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29644401/-skill-retention-using-extraglottic-airways-in-out-of-hospital-emergencies-efficacy-and-long-term-results-of-simulator-based-medical-education-a-prospective-follow-up-study
#17
V Mann, F Limberg, S T W Mann, S Little, M Müller, M Sander, R Röhrig
OBJECTIVE: For emergency medicine personnel (EMP), there is little evidence concerning the adequate timing for refresher courses to maintain routine in the application of extraglottic airways. The aim of this study was to evaluate the efficacy and long-term results of a simulator-based education concept teaching the basic airway management skills with extraglottic airways for EMP and also to draw conclusions concerning the adequate time interval for refresher courses. METHODS: By use of an explorative, prospective simulator-study with nonphysician EMP, airway management skills using the Larynxmaske Supreme® (LMA‑S) after an introduction lecture were examined...
April 11, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29644281/thyrohyoid-membrane-transection-caused-by-a-stab-injury
#18
Dongsub Noh, Kwang Hee Yeo, Hyun Min Cho, Chan Yong Park
Background: The thyrohyoid membrane is located between the hyoid bone and thyroid cartilage. Transection of the thyrohyoid membrane can be fatal. Case presentation: A 54-year-old man presented to the emergency room after attempting to commit suicide by cutting his neck. An endotracheal tube was inserted through the thyrohyoid membrane, which had been cut almost completely. After a tracheostomy, temporary wound closure was performed due to coagulopathy caused by hemorrhagic shock...
December 2017: Trauma Case Reports
https://www.readbyqxmd.com/read/29643628/pediatric-critical-incidents-reported-over-15-years-at-a-tertiary-care-teaching-hospital-of-a-developing-country
#19
Shemila Abbasi, Fauzia Anis Khan, Sobia Khan
Background and Aims: The role of critical incident (CI) reporting is well established in improving patient safety but only a limited number of available reports relate to pediatric incidents. Our aim was to analyze the reported CIs specific to pediatric patients in our database and to reevaluate the value of this program in addressing issues in pediatric anesthesia practice. Material and Methods: Incidents related to pediatric population from neonatal period till the age of 12 years were selected...
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29642409/squamous-cell-carcinoma-antigen-2-scca2-serpinb4-an-emerging-biomarker-for-skin-inflammatory-diseases
#20
REVIEW
Kenji Izuhara, Yukie Yamaguchi, Shoichiro Ohta, Satoshi Nunomura, Yasuhiro Nanri, Yoshinori Azuma, Noriko Nomura, Yasuhiko Noguchi, Michiko Aihara
Squamous cell carcinoma antigens 1 and 2 (SCCA1 and 2, SERPIN B3 and B4), members of the ovalbumin serpin (ov-serpin)/clade B serpin family, were originally discovered as tumor-specific antigens and are used as tumor markers for various kinds of squamous cell carcinomas. Recently, our understanding of the underlying mechanisms of how SCCA1/2 enhance tumor growth has greatly increased. Moreover, it has been shown that SCCA1/2 are involved in the pathogenesis of several inflammatory diseases: asthma, psoriasis, and atopic dermatitis (AD)...
April 6, 2018: International Journal of Molecular Sciences
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