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https://www.readbyqxmd.com/read/28431056/long-term-outcome-of-transvenous-pacemaker-implantation-in-infants-a-retrospective-cohort-study
#1
Laura M Vos, Janneke A E Kammeraad, Matthias W Freund, Andreas C Blank, Johannes M P J Breur
Aim: Evaluation of long-term outcome of transvenous pacemaker (PM) implantation in infants. Methods and Results: A retrospective analysis of all transvenous PM implantations in infants <10 kg between September 1997 and October 2001 was made. Indications for PM implantation, age at implantation, and determinants of long-term outcome including cardiac function, PM function, and PM (system) complications were noted. Seven patients underwent transvenous VVI(R) PM implantation...
April 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28430780/the-importance-of-standardization-for-biodiversity-comparisons-a-case-study-using-autonomous-reef-monitoring-structures-arms-and-metabarcoding-to-measure-cryptic-diversity-on-mo-orea-coral-reefs-french-polynesia
#2
Emma Ransome, Jonathan B Geller, Molly Timmers, Matthieu Leray, Angka Mahardini, Andrianus Sembiring, Allen G Collins, Christopher P Meyer
The advancement of metabarcoding techniques, declining costs of high-throughput sequencing and development of systematic sampling devices, such as autonomous reef monitoring structures (ARMS), have provided the means to gather a vast amount of diversity data from cryptic marine communities. However, such increased capability could also lead to analytical challenges if the methods used to examine these communities across local and global scales are not standardized. Here we compare and assess the underlying biases of four ARMS field processing methods, preservation media, and current bioinformatic pipelines in evaluating diversity from cytochrome c oxidase I metabarcoding data...
2017: PloS One
https://www.readbyqxmd.com/read/28430726/vaginal-mesh-removal-outcomes-eight-years-of-experience-at-an-academic-hospital
#3
Olivia O Cardenas-Trowers, Pouran Malekzadeh, David E Nix, Kenneth D Hatch
OBJECTIVES: The purpose of this study is to describe the clinical history leading up to and the outcomes after vaginal mesh removal surgery at an academic hospital. METHODS: A retrospective case series of patients who underwent vaginal mesh removal from 2008 to 2015 was conducted. Demographics, clinical history, physical examination, pre- and postoperative symptoms, and number and type of reoperations were abstracted. RESULTS: Between February 2008 and November 2015, 83 patients underwent vaginal mesh removal surgery at our hospital...
April 20, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28430662/histone-demethylase-jmjd3-regulates-cd11a-expression-through-changes-in-histone-h3k27-tri-methylation-levels-in-cd4-t-cells-of-patients-with-systemic-lupus-erythematosus
#4
Heng Yin, Haijing Wu, Ming Zhao, Qing Zhang, Hai Long, Siqi Fu, Qianjin Lu
Aberrant CD11a overexpression in CD4+ T cells induces T cell auto-reactivity, which is an important factor for systemic lupus erythematosus (SLE) pathogenesis. Although many studies have focused on CD11a epigenetic regulation, little is known about histone methylation. JMJD3, as a histone demethylase, is capable of specifically removing the trimethyl group from the H3K27 lysine residue, triggering target gene activation. Here, we examined the expression and function of JMJD3 in CD4+ T cells from SLE patients...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28429550/parathyroid-hormone-targets-in-chronic-kidney-disease-and-managing-severe-hyperparathyroidism
#5
Carmel M Hawley, Stephen G Holt
Appropriate targets for parathyroid hormone (PTH) in patients with chronic kidney disease (CKD) stages 3-5D are controversial, as are the means by which these targets might be achieved. Secondary hyperparathyroidism is linked to symptoms like bone pain and itch, in addition to less clinically overt issues like bone fragility as well as vascular and soft tissue calcification which may lead to adverse hard endpoints, particularly fracture and death. Recognized therapies for managing a rising PTH include vitamin D analogues, with or without calcimimetic (where available), in addition to management of serum mineral concentrations with diet, binders and dialysis...
March 2017: Nephrology
https://www.readbyqxmd.com/read/28429004/binding-site-opening-by-loop-c-shift-and-chloride-ion-pore-interaction-in-the-gabaa-receptor-model
#6
M A Michałowski, S Kraszewski, J W Mozrzymas
GABAA receptors (GABAARs) are crucial in mediating inhibition in the adult mammalian brain. Although the kinetics of this receptor has been extensively studied, the molecular picture of interactions occurring at various channel conformations remains elusive. While electrophysiology combined with mutagenesis sheds light on the role of specific residues, ultrastructural studies reveal static structures which, in the case of GABAARs, are limited to the β3 homomer. To take advantage of the newest crystal structures of cys-loop receptors, a homology model of α1β2γ2 GABAAR in the unbound closed state was built using a template of the homomeric glycine receptor in the closed state...
April 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28427784/prehospital-removal-improves-neurological-outcomes-in-elderly-patient-with-foreign-body-airway-obstruction
#7
Yutaka Igarashi, Shoji Yokobori, Yudai Yoshino, Tomohiko Masuno, Masato Miyauchi, Hiroyuki Yokota
OBJECTIVE: In Japan, the number of patients with foreign body airway obstruction by food is rapidly increasing with the increase in the population of the elderly and a leading cause of unexpected death. This study aimed to determine the factors that influence prognosis of these patients. METHODS: This is a retrospective single institutional study. A total of 155 patients were included. We collected the variables from the medical records and analyzed them to determine the factors associated with patient outcome...
April 10, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28427656/ultrasonically-assisted-removal-of-congo-red-phloxine-b-and-fast-green-fcf-in-ternary-mixture-using-novel-nanocomposite-following-their-simultaneous-analysis-by-derivative-spectrophotometry
#8
Jaleh Pooralhossini, Mehrorang Ghaedi, Mohammad Ali Zanjanchi, Arash Asfaram
In this study dependency of simultaneous adsorption of Congo Red (CR), Phloxine B (BP) and Fast green FCF (FG) onto CuS/ZnS nanocomposites loaded on activated carbon (CuS/ZnS-NCs-AC) to pH, adsorbent mass, sonication time and initial dyes concentration were modeled and optimized, while CuS/ZnS-NCs-AC was identified by XRD, FESEM and EDS analysis. CR, PB and FG concentration determination were undertaken by first and second order derivative spectrophotometry in ternary mixture. According to central composite design (CCD) based on desirability function (DF), the best experimental conditions was set as pH 6...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28427336/protocol-for-the-home-hazards-removal-program-harp-study-a-pragmatic-randomized-clinical-trial-and-implementation-study
#9
Susan Stark, Emily Somerville, Marian Keglovits, Jane Conte, Melody Li, Yi-Ling Hu, Yan Yan
BACKGROUND: Falls remain the leading cause of injury, long-term disability, premature institutionalization, and injury-related mortality in the older adult population. Home modifications, when delivered by occupational therapists, can reduce falls among high-risk community-dwelling older adults by 39%. However, home-modification implementation is not standard practice in the United States. The goal of the Home Hazard Removal Program (HARP) study is to implement an evidence-based home modification intervention for older adults designed to reduce the incidence of falls through an aging services network...
April 20, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28427006/regeneration-of-pilot-scale-ion-exchange-columns-for-hexavalent-chromium-removal
#10
Julie A Korak, Richard Huggins, Miguel Arias-Paic
Due to stricter regulations, some drinking water utilities must implement additional treatment processes to meet potable water standards for hexavalent chromium (Cr(VI)), such as the California limit of 10 μg/L. Strong base anion exchange is effective for Cr(VI) removal, but efficient resin regeneration and waste minimization are important for operational, economic and environmental considerations. This study compared multiple regeneration methods on pilot-scale columns on the basis of regeneration efficiency, waste production and salt usage...
March 9, 2017: Water Research
https://www.readbyqxmd.com/read/28426987/a-review-on-nitrous-oxide-n2o-emissions-during-biological-nutrient-removal-from-municipal-wastewater-and-sludge-reject-water
#11
REVIEW
Theoni Maria Massara, Simos Malamis, Albert Guisasola, Juan Antonio Baeza, Constantinos Noutsopoulos, Evina Katsou
Nitrous oxide (N2O) is an important pollutant which is emitted during the biological nutrient removal (BNR) processes of wastewater treatment. Since it has a greenhouse effect which is 265 times higher than carbon dioxide, even relatively small amounts can result in a significant carbon footprint. Biological nitrogen (N) removal conventionally occurs with nitrification/denitrification, yet also through advanced processes such as nitritation/denitritation and completely autotrophic N-removal. The microbial pathways leading to the N2O emission include hydroxylamine oxidation and nitrifier denitrification, both activated by ammonia oxidizing bacteria, and heterotrophic denitrification...
April 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28426982/redox-environment-in-stem-and-differentiated-cells-a-quantitative-approach
#12
O G Lyublinskaya, Ju S Ivanova, N A Pugovkina, I V Kozhukharova, Z V Kovaleva, A N Shatrova, N D Aksenov, V V Zenin, Yu A Kaulin, I A Gamaley, N N Nikolsky
Stem cells are believed to maintain a specific intracellular redox status through a combination of enhanced removal capacity and limited production of ROS. In the present study, we challenge this assumption by developing a quantitative approach for the analysis of the pro- and antioxidant ability of human embryonic stem cells in comparison with their differentiated descendants, as well as adult stem and non-stem cells. Our measurements showed that embryonic stem cells are characterized by low ROS level, low rate of extracellular hydrogen peroxide removal and low threshold for peroxide-induced cytotoxicity...
April 11, 2017: Redox Biology
https://www.readbyqxmd.com/read/28426967/an-intrinsic-epigenetic-barrier-for-functional-axon-regeneration
#13
Yi-Lan Weng, Ran An, Jessica Cassin, Jessica Joseph, Ruifa Mi, Chen Wang, Chun Zhong, Seung-Gi Jin, Gerd P Pfeifer, Alfonso Bellacosa, Xinzhong Dong, Ahmet Hoke, Zhigang He, Hongjun Song, Guo-Li Ming
Mature neurons in the adult peripheral nervous system can effectively switch from a dormant state with little axonal growth to robust axon regeneration upon injury. The mechanisms by which injury unlocks mature neurons' intrinsic axonal growth competence are not well understood. Here, we show that peripheral sciatic nerve lesion in adult mice leads to elevated levels of Tet3 and 5-hydroxylmethylcytosine in dorsal root ganglion (DRG) neurons. Functionally, Tet3 is required for robust axon regeneration of DRG neurons and behavioral recovery...
April 19, 2017: Neuron
https://www.readbyqxmd.com/read/28425705/facile-aqueous-phase-synthesis-of-ptau-bi2o3-hybrid-catalyst-for-efficient-electro-oxidation-of-ethanol
#14
Sumanta Sarkar, Rajkumar Jana, Hiranmayee Vadlamani, Swetha Ramani, Dundappa Mumbaraddi, Sebastian C Peter
In this work, we present a facile aqueous phase synthesis of a hybrid catalyst consists of PtAu alloy supported on Bi2O3 microspheres. Multistep reduction of HAuCl4 and K2PtCl4 salts on Bi2O3 and subsequent annealing leads to the formation of this hybrid catalyst. To the best of our knowledge, this is the first report of using Bi2O3 as a catalyst support in Fuel cell applications. The material was characterized by powder X-ray diffraction and various microscopic techniques. This composite showed remarkable activity as well as stability towards the electro-oxidation of ethanol in comparison to commercially available Pt/C...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28424663/antimicrobial-photodynamic-therapy-against-endodontic-enterococcus-faecalis-and-candida-albicans-mono-and-mixed-biofilms-in-the-presence-of-photosensitizers-a-comparative-study-with-classical-endodontic-irrigants
#15
Patrícia Diogo, Chantal Fernandes, Francisco Caramelo, Marta Mota, Isabel M Miranda, M A F Faustino, M G P M S Neves, Marciana P Uliana, Kleber T de Oliveira, João M Santos, Teresa Gonçalves
Endodontic biofilms eradication from the infected root canal system remains as the primary focus in endodontic field. In this study, it was assessed the efficacy of antimicrobial Photodynamic Therapy (aPDT) with the Zn(II)chlorin e6 methyl ester (Zn(II)e6Me) activated by red light against monospecies and mixed biofilms of Enterococcus faecalis and Candida albicans. The results were compared with the ones obtained with Rose Bengal (RB), Toluidine Blue-O (TBO), the synthetic tetracationic porphyrin (TMPyP) as well as classical endodontic irrigants (3% NaOCl, 17% EDTA and 2% CHX)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28424572/functional-sensitivity-of-2d-simultaneous-multi-slice-echo-planar-imaging-effects-of-acceleration-on-g-factor-and-physiological-noise
#16
Nick Todd, Oliver Josephs, Peter Zeidman, Guillaume Flandin, Steen Moeller, Nikolaus Weiskopf
Accelerated data acquisition with simultaneous multi-slice (SMS) imaging for functional MRI studies leads to interacting and opposing effects that influence the sensitivity to blood oxygen level-dependent (BOLD) signal changes. Image signal to noise ratio (SNR) is decreased with higher SMS acceleration factors and shorter repetition times (TR) due to g-factor noise penalties and saturation of longitudinal magnetization. However, the lower image SNR is counteracted by greater statistical power from more samples per unit time and a higher temporal Nyquist frequency that allows for better removal of spurious non-BOLD high frequency signal content...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28424488/improving-superconductivity-in-bafe2as2-based-crystals-by-cobalt-clustering-and-electronic-uniformity
#17
L Li, Q Zheng, Q Zou, S Rajput, A O Ijaduola, Z Wu, X P Wang, H B Cao, S Somnath, S Jesse, M Chi, Z Gai, D Parker, A S Sefat
Quantum materials such as antiferromagnets or superconductors are complex in that chemical, electronic, and spin phenomena at atomic scales can manifest in their collective properties. Although there are some clues for designing such materials, they remain mainly unpredictable. In this work, we find that enhancement of transition temperatures in BaFe2As2-based crystals are caused by removing local-lattice strain and electronic-structure disorder by thermal annealing. While annealing improves Néel-ordering temperature in BaFe2As2 crystal (T N  = 132 K to 136 K) by improving in-plane electronic defects and reducing overall a-lattice parameter, it increases superconducting-ordering temperature in optimally cobalt-doped BaFe2As2 crystal (T c = 23 to 25 K) by precipitating-out the cobalt dopants and giving larger overall a-lattice parameter...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28424476/neurons-export-extracellular-vesicles-enriched-in-cysteine-string-protein-and-misfolded-protein-cargo
#18
Jingti Deng, Carolina Koutras, Julien Donnelier, Mana Alshehri, Maryam Fotouhi, Martine Girard, Steve Casha, Peter S McPherson, Stephen M Robbins, Janice E A Braun
The fidelity of synaptic transmission depends on the integrity of the protein machinery at the synapse. Unfolded synaptic proteins undergo refolding or degradation in order to maintain synaptic proteostasis and preserve synaptic function, and buildup of unfolded/toxic proteins leads to neuronal dysfunction. Many molecular chaperones contribute to proteostasis, but one in particular, cysteine string protein (CSPα), is critical for proteostasis at the synapse. In this study we report that exported vesicles from neurons contain CSPα...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28424231/mroh1-a-lysosomal-regulator-localised-by-wash-generated-actin
#19
Peter A Thomason, Jason S King, Robert H Insall
The steps leading to constitutive exocytosis are poorly understood. In Dictyostelium WASH complex mutants, exocytosis is blocked, so cells that take up fluorescent dextran from the medium retain it and remain fluorescent. Here we establish a FACS-based method to select cells that retain fluorescent dextran, allowing identification of mutants with disrupted exocytosis. Screening a pool of random mutants identified the WASH complex, as expected, and multiple mutants in the conserved HEAT-repeat containing protein Mroh1...
April 19, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28423343/chitosan-as-coagulant-on-cyanobacteria-in-lake-restoration-management-may-cause-rapid-cell-lysis
#20
Maíra Mucci, Natalia Pessoa Noyma, Leonardo de Magalhães, Marcela Miranda, Frank van Oosterhout, Iamê Alves Guedes, Vera L M Huszar, Marcelo Manzi Marinho, Miquel Lürling
Combining coagulant and ballast to remove cyanobacteria from the water column is a promising restoration technique to mitigate cyanobacterial nuisance in surface waters. The organic, biodegradable polymer chitosan has been promoted as a coagulant and is viewed as non-toxic. In this study, we show that chitosan may rapidly compromise membrane integrity and kill certain cyanobacteria leading to release of cell contents in the water. A strain of Cylindrospermopsis raciborskii and one strain of Planktothrix agardhii were most sensitive...
April 10, 2017: Water Research
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