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https://www.readbyqxmd.com/read/29156764/the-neil1-g83d-germline-dna-glycosylase-variant-induces-genomic-instability-and-cellular-transformation
#1
Heather A Galick, Carolyn G Marsden, Scott Kathe, Julie A Dragon, Lindsay Volk, Antonia A Nemec, Susan S Wallace, Aishwarya Prakash, Sylvie Doublié, Joann B Sweasy
Base excision repair (BER) is a key genome maintenance pathway. The NEIL1 DNA glycosylase recognizes oxidized bases, and likely removes damage in advance of the replication fork. The rs5745906 SNP of the NEIL1 gene is a rare human germline variant that encodes the NEIL1 G83D protein, which is devoid of DNA glycosylase activity. Here we show that expression of G83D NEIL1 in MCF10A immortalized but non-transformed mammary epithelial cells leads to replication fork stress. Upon treatment with hydrogen peroxide, we observe increased levels of stalled replication forks in cells expressing G83D NEIL1 versus cells expressing the wild-type (WT) protein...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156596/microvesicle-involvement-in-shiga-toxin-associated-infection
#2
REVIEW
Annie Villysson, Ashmita Tontanahal, Diana Karpman
Shiga toxin is the main virulence factor of enterohemorrhagic Escherichia coli, a non-invasive pathogen that releases virulence factors in the intestine, causing hemorrhagic colitis and, in severe cases, hemolytic uremic syndrome (HUS). HUS manifests with acute renal failure, hemolytic anemia and thrombocytopenia. Shiga toxin induces endothelial cell damage leading to platelet deposition in thrombi within the microvasculature and the development of thrombotic microangiopathy, mostly affecting the kidney. Red blood cells are destroyed in the occlusive capillary lesions...
November 19, 2017: Toxins
https://www.readbyqxmd.com/read/29155725/an-efficient-and-reproducible-protocol-for-distraction-osteogenesis-in-a-rat-model-leading-to-a-functional-regenerated-femur
#3
Martine Pithioux, Flavy Roseren, Christian Jalain, Franck Launay, Philippe Charpiot, Patrick Chabrand, Sandrine Roffino, Edouard Lamy
This protocol describes the use of a newly developed external fixator for distraction osteogenesis in a rat femoral model. Distraction osteogenesis (DO) is a surgical technique leading to bone regeneration after an osteotomy. The osteotomized extremities are moved away from each other by gradual distraction to reach the desired elongation. This procedure is widely used in humans for lower and upper limb lengthening, treatment after a bone nonunion, or the regeneration of a bone defect following surgery for bone tumor excision, as well as in maxillofacial reconstruction...
October 23, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155714/application-of-multicolor-flpout-technique-to-study-high-resolution-single-cell-morphologies-and-cell-interactions-of-glia-in-drosophila
#4
Sara Batelli, Malte Kremer, Christophe Jung, Ulrike Gaul
Cells display different morphologies and complex anatomical relationships. How do cells interact with their neighbors? Do the interactions differ between cell types or even within a given type? What kinds of spatial rules do they follow? The answers to such fundamental questions in vivo have been hampered so far by a lack of tools for high resolution single cell labeling. Here, a detailed protocol to target single cells with a MultiColor FlpOut (MCFO) technique is provided. This method relies on three differently tagged reporters (HA, FLAG and V5) under UAS control that are kept silent by a transcriptional terminator flanked by two FRT sites (FRT-stop-FRT)...
October 20, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155706/comprehensive-endovascular-and-open-surgical-management-of-cerebral-arteriovenous-malformations
#5
Robert C Rennert, Jeffrey A Steinberg, Vincent J Cheung, David R Santiago-Dieppa, Jeffrey Scott Pannell, Alexander A Khalessi
Arteriovenious malformations (AVMs) are associated with significant morbidity and mortality, and have a rupture risk of ~3% per year. Treatment of AVMs must be tailored specifically to the lesion, with surgical resection being the gold standard for small, accessible lesions. Pre-operative embolization of AVMs can reduce nidal blood flow and remove high-risk AVM features such as intranidal or venous aneurysms, thereby simplifying a challenging neurosurgical procedure. Herein, we describe our approach for the staged endovascular embolization and open resection of AVMs, and highlight the advantages of having a comprehensively trained neurovascular surgeon leading a multi-disciplinary clinical team...
October 20, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155549/icephobic-behavior-of-uv-cured-polymer-networks-incorporated-into-slippery-lubricant-infused-porous-surfaces-improving-slips-durability
#6
Matthew J Coady, Michael Wood, Gregory Q Wallace, Kent E Nielsen, Anne-Marie Kietzig, François Lagugné-Labarthet, Paul J Ragogna
Ice accretion causes damage on power generation infrastructure, leading to mechanical failure. Icephobic materials are being researched so that ice buildup on these surfaces will be shed before the weight of the ice causes catastrophic damage. Recently, lubricated materials showed the lowest recorded forces of ice adhesion, and therefore lubricated materials are considered the state-of-the-art. Slippery lubricant-infused porous surfaces (SLIPS) are one type of such materials. SLIPS are initially very effective at repelling ice, but the trapped fluid layer that affords their icephobic properties is depleted by repeated ice removal...
November 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29155111/surgical-treatment-of-spinal-synovial-cysts-in-the-elderly-symptoms-treatment-course-and-outcome-in-patients-over-75-years
#7
Markus Bruder, Florian Gessler, Adriano Cattani, Christian Droste, Volker Seifert, Matthias Setzer, Gerhard Marquardt
OBJECTIVE: The ongoing aging of our society leads to a rising number of elderly patients with progressive degeneration of the spine, associated with synovial cysts. In the elderly, surgical treatment may be particularly challenging because of comorbidities. METHODS: Patients treated in our department between 1999 and 2014 for spinal synovial cysts were screened. The 28 patients aged 75 years and older were classified as "elderly". Those were compared with 96 patients between 50 and 74 years...
November 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29153865/treatments-of-missing-values-in-large-national-data-affect-conclusions-the-impact-of-multiple-imputation-on-arthroplasty-research
#8
Nathaniel T Ondeck, Michael C Fu, Laura A Skrip, Ryan P McLynn, Edwin P Su, Jonathan N Grauer
BACKGROUND: Despite the advantages of large, national datasets, one continuing concern is missing data values. Complete case analysis, where only cases with complete data are analyzed, is commonly used rather than more statistically rigorous approaches such as multiple imputation. This study characterizes the potential selection bias introduced using complete case analysis and compares the results of common regressions using both techniques following unicompartmental knee arthroplasty...
October 26, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29150961/modulation-of-igg1-immunoeffector-function-by-glycoengineering-of-the-gdp-fucose-biosynthesis-pathway
#9
Ronan M Kelly, Ronald L Kowle, Zhirui Lian, Beth A Strifler, Derrick R Witcher, Bhavin S Parekh, Tongtong Wang, Christopher C Frye
Cross-linking of the Fcγ receptors expressed on the surface of hematopoietic cells by IgG immune complexes triggers the activation of key immune effector mechanisms, including antibody-dependent cell mediated cytotoxicity (ADCC). A conserved N-glycan positioned at the N-terminal region of the IgG CH 2 domain is critical in maintaining the quaternary structure of the molecule for Fcγ receptor engagement. The removal of a single core fucose residue from the N-glycan results in a considerable increase in affinity for FcγRIIIa leading to an enhanced receptor-mediated immunoeffector function...
November 18, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29150943/muscle-regeneration-potential-and-satellite-cell-activation-profile-during-recovery-following-hindlimb-immobilization-in-mice
#10
Maria Guitart, Josep Lloreta, Laura Mañas-Garcia, Esther Barreiro
Reduced muscle activity leads to muscle atrophy and function loss in patients and animal models. Satellite cells (SCs) are postnatal muscle stem cells that play a pivotal role in skeletal muscle regeneration following injury. The regenerative potential, satellite cell numbers, and markers during recovery following immobilization of the hindlimb for seven days were explored. In mice exposed to seven days of hindlimb immobilization, in those exposed to recovery (seven days, splint removal), and in contralateral control muscles, muscle precursor cells were isolated from all hindlimb muscles (fluorescence-activated cell sorting, FACS), and SCs and muscle regeneration were identified using immunofluorescence (gastrocnemius and soleus) and electron microscopy (EM, gastrocnemius)...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29149555/mapping-the-reactions-in-a-single-zero-valent-iron-nanoparticle
#11
Lan Ling, Xiao-Yue Huang, Meirong Li, Wei-Xian Zhang
Nanoscale zero-valent iron (nZVI) posseses unique functionalities for metal-metalloid removal and sequestration. So far, direct evidence on the heavy metal-iron reactions in the solid phase is still limited due to low concentration of heavy metals and small size of nanoparticles. In this work, angstrom-resolution spectral mappings on the reactions of nZVI with chromate, arsenate, nickel, silver, cesium, and zinc ions are presented. This work was achieved with spherical aberration-corrected scanning transmission electron microscopy integrated with high-sensitivity X-ray energy-dispersive spectroscopy scanning transmission electron microscopy (XEDS-STEM)...
November 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29149156/survival-analysis-of-occipital-nerve-stimulator-leads-placed-under-fluoroscopic-guidance-with-and-without-ultrasonography
#12
James H Jones, Alison Brown, Daniel Moyse, Wenjing Qi, Lance Roy
BACKGROUND: Electrical stimulation of the greater occipital nerves is performed to treat pain secondary to chronic daily headaches and occipital neuralgia. The use of fluoroscopy alone to guide the surgical placement of electrodes near the greater occipital nerves disregards the impact of tissue planes on lead stability and stimulation efficacy. OBJECTIVE: We hypothesized that occipital neurostimulator (ONS) leads placed with ultrasonography combined with fluoroscopy would demonstrate increased survival rates and times when compared to ONS leads placed with fluoroscopy alone...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29149117/-influence-of-titanium-dioxide-activated-under-visible-light-on-survival-of-mold-fungi
#13
Daria Kądziołka, Paulina Rokicka, Agata Markowska-Szczupak, Antoni W Morawski
BACKGROUND: In public and residential buildings, fungi are usually found in the dust or growing on building materials medium such. It has been known that a number of their spores may contaminate the indoor environment and deteriorate air quality in accommodation spaces. Previously designed air cleaning systems do not guarantee a complete removal of agents harmful to humans and animals. Therefore, there is a great need to develop a new solution to remove molds from indoor air. In recent years, photocatalysis based on titanium dioxide (TiO<sub>2</sub>) has been proposed as an effective method for air pollutants removal...
November 17, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/29148312/experimental-analysis-of-the-process-parameters-affecting-bone-burring-operations
#14
Jonathan R Kusins, O Remus Tutunea-Fatan, Louis M Ferreira
The experimental quantification of the process parameters associated with bone burring represents a desirable outcome both from the perspective of an optimized surgical procedure as well as that of a future implementation into the design of closed-loop controllers used in robot-assisted bone removal operations. Along these lines, the present study presents an experimental investigation of the effects that tool type, rotational speed of the tool, depth of cut, feed rate, cutting track overlap, and tool angle (to a total of 864 total unique combinations) have on bone temperature, tool vibration, and cutting forces associated with superficial bone removal operations...
November 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29148069/long-term-oral-exposure-to-safe-dose-of-bisphenol-a-in-association-with-high-fat-diet-stimulate-the-prostatic-lesions-in-a-rodent-model-for-prostate-cancer
#15
Camila H Facina, Silvana G P Campos, Bianca F Gonçalves, Rejane M Góes, Patricia S L Vilamaior, Sebastião R Taboga
BACKGROUND: Studies have shown that exposure to environmental chemicals known as endocrine disruptors can cause permanent changes in genital organs, such as the prostate. Among these environmental chemicals stands out bisphenol A (BPA). Another factor associated with prostate changes is the consumption of a high-fat diet. Although the relationship between the consumption of a high-fat diet and an increased risk of prostate cancer is well established, the mechanisms that lead to the establishment of this disease are not completely understood, nor the simultaneous action of BPA and high-fat diet...
November 17, 2017: Prostate
https://www.readbyqxmd.com/read/29147493/the-effect-of-the-ovarian-varicose-vein-on-the-dna-methylation-in-the-rat-s-oocyte
#16
Amirhossein Mohammadi, Bagher Minaei Zangi, Mahshid Delfan Azari, Rafieh Alizadeh, Mohammad Salehi, Erfan Daneshi, Mohammad Jafar Rezaei, Mehdi Abbasi
Objectives: We intended to determine whether the ovarian varicose which is one of the common etiologies of the pelvic congestion syndrome, has the ability to interfere with the DNA methylation reprogramming in the oocyte and thereby affect the oocyte quality or not. Materials and Methods: Varicose model was induced according to the Turner's method in the rats. Briefly, a 20-gauge needle was placed on the left renal vein and a thread was tied over both the needle and the renal vein medial to the insertion of the ovarian vein, and then the needle was removed...
October 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29147441/intrahepatic-biliary-metastasis-of-colonic-adenocarcinoma-a-case-report-with-immunohistochemical-analysis
#17
Keisuke Kawashima, Naoki Watanabe, Sho Tawada, Takahito Adachi, Makoto Yamada, Yusuke Kitoh, Tamotsu Takeuchi, Takuji Tanaka
Although intrabiliary metastasis of carcinoma in the liver is unusual, intraductal and/or intraepithelial spread of cancer cells along intrahepatic bile ducts is now well recognized as hepatic metastasis. However, several clinical and laboratory findings, including images, lead us to differentially diagnose from primary intrahepatic cholangiocarcinoma. We report here on a case of colonic adenocarcinoma that metastasized to the liver with spread along with the intrahepatic bile duct of S5/6 area. The patient was a 51-year-old man and clinically diagnosed liver metastasis of sigmoid colon cancer (tub2, pMP, ly1, v0, n0), which was diagnosed and treated by sigmoidectomy 7 years ago...
June 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29146910/an-unexpected-protein-interaction-promotes-drug-resistance-in-leukemia
#18
Aaron Pitre, Yubin Ge, Wenwei Lin, Yao Wang, Yu Fukuda, Jamshid Temirov, Aaron H Phillips, Jennifer L Peters, Yiping Fan, Jing Ma, Amanda Nourse, Chandrima Sinha, Hai Lin, Richard Kriwacki, James R Downing, Tanja A Gruber, Victoria E Centonze, Anjaparavanda P Naren, Taosheng Chen, John D Schuetz
The overall survival of patients with acute myeloid leukemia (AML) is poor and identification of new disease-related therapeutic targets remains a major goal for this disease. Here we show that expression of MPP1, a PDZ-domain-containing protein, highly correlated with ABCC4 in AML, is associated with worse overall survival in AML. Murine hematopoietic progenitor cells overexpressing MPP1 acquired the ability to serially replate in methylcellulose culture, a property crucially dependent upon ABCC4. The highly conserved PDZ-binding motif of ABCC4 is required for ABCC4 and MPP1 to form a protein complex, which increased ABCC4 membrane localization and retention, to enhance drug resistance...
November 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29146528/hierarchical-bayesian-models-for-the-autonomic-based-concealed-information-test
#19
Yusuke Shibuya, Kensuke Okada, Tokihiro Ogawa, Izumi Matsuda, Michiko Tsuneoka
The concealed information test (CIT) is a psychophysiological memory detection technique for examining whether an examinee recognizes crime-relevant information. In current statistical analysis practice, the autonomic responses are usually transformed into Z scores within individuals to remove inter- and intra-individual variability. However, this conventional procedure leads to overestimation of the effect size, specifically the standardized mean difference of the autonomic responses between the crime-relevant information and the crime-irrelevant information...
November 13, 2017: Biological Psychology
https://www.readbyqxmd.com/read/29145161/cyp450-enzyme-specific-enantioselective-species-specific-response-for-metalaxyl-in-in-vitro-hepatic-cells
#20
Wei Xie, Fangxing Yang
Although enantioselective accumulation of chiral pesticide has been reported in organisms, the mechanisms remain unclear. In this study, the effects of chiral pesticide metalaxyl on CYP1A1, CYP1A2, CYP2B1, CYP2B2, CYP2E1 and CYP3A were investigated in human hepatoma HepG2, rat hepatic H4IIE, chicken hepatic LMH and grass carp hepatic L8824 cells. Moreover, the residual concentrations and enantiomeric ratios (ERs) of metalaxyl were also detected in the medium. The results showed the responses of these CYP450s to metalaxyl were enzyme-dependent and species-dependent in the four cells...
November 13, 2017: Ecotoxicology and Environmental Safety
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