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https://www.readbyqxmd.com/read/28806762/a-becn1-mutation-mediates-hyperactive-autophagic-sequestration-of-amyloid-oligomers-and-improved-cognition-in-alzheimer-s-disease
#1
Altea Rocchi, Soh Yamamoto, Tabitha Ting, Yuying Fan, Katherine Sadleir, Yigang Wang, Weiran Zhang, Sui Huang, Beth Levine, Robert Vassar, Congcong He
Impairment of the autophagy pathway has been observed during the pathogenesis of Alzheimer's disease (AD), a neurodegenerative disorder characterized by abnormal deposition of extracellular and intracellular amyloid β (Aβ) peptides. Yet the role of autophagy in Aβ production and AD progression is complex. To study whether increased basal autophagy plays a beneficial role in Aβ clearance and cognitive improvement, we developed a novel genetic model to hyperactivate autophagy in vivo. We found that knock-in of a point mutation F121A in the essential autophagy gene Beclin 1/Becn1 in mice significantly reduces the interaction of BECN1 with its inhibitor BCL2, and thus leads to constitutively active autophagy even under non-autophagy-inducing conditions in multiple tissues, including brain...
August 14, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28805207/periodontal-diseases
#2
REVIEW
Denis F Kinane, Panagiota G Stathopoulou, Panos N Papapanou
Periodontal diseases comprise a wide range of inflammatory conditions that affect the supporting structures of the teeth (the gingiva, bone and periodontal ligament), which could lead to tooth loss and contribute to systemic inflammation. Chronic periodontitis predominantly affects adults, but aggressive periodontitis may occasionally occur in children. Periodontal disease initiation and propagation is through a dysbiosis of the commensal oral microbiota (dental plaque), which then interacts with the immune defences of the host, leading to inflammation and disease...
June 22, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28803940/real-time-motion-analytics-during-brain-mri-improve-data-quality-and-reduce-costs
#3
Nico U F Dosenbach, Jonathan M Koller, Eric A Earl, Oscar Miranda-Dominguez, Rachel L Klein, Andrew N Van, Abraham Z Snyder, Bonnie J Nagel, Joel T Nigg, Annie Nguyen, Victoria Wesevich, Deanna J Greene, Damien A Fair
Head motion systematically distorts clinical and research MRI data. Motion artifacts have biased findings from many structural and functional brain MRI studies. An effective way to remove motion artifacts is to exclude MRI data frames affected by head motion. However, such post-hoc frame censoring can lead to data loss rates of 50% or more in our pediatric patient cohorts. Hence, many scanner operators collect additional 'buffer data', an expensive practice that, by itself, does not guarantee sufficient high-quality MRI data for a given participant...
August 10, 2017: NeuroImage
https://www.readbyqxmd.com/read/28803337/production-of-rhamnolipids-by-semi-solid-state-fermentation-with-pseudomonas-aeruginosa-rg18-for-heavy-metal-desorption
#4
Jianrong Wu, Jingbo Zhang, Panpan Wang, Li Zhu, Minjie Gao, Zhiyong Zheng, Xiaobei Zhan
Foaming problem and cost of substrate limit the commercial application of rhamnolipids, a potential biosurfactant produced by Pseudomonas aeruginosa. We explored the production of rhamnolipids by a semi-solid-state (SSS) fermentation strategy with glycerol as carbon source and rapeseed/wheat bran as matrix, along with the capacity of the produced rhamnolipids to solubilize lead and cadmium in aqueous solution. Structural analysis by MALDI-TOF MS indicated the increased proportion of mono-rhamnolipids from SSS fermentation...
August 12, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28803155/assisted-phytoremediation-of-a-multi-contaminated-soil-investigation-on-arsenic-and-lead-combined-mobilization-and-removal
#5
Meri Barbafieri, Francesca Pedron, Gianniantonio Petruzzelli, Irene Rosellini, Elisabetta Franchi, Roberto Bagatin, Marco Vocciante
The removal of contaminants from an earthy matrix by phytoremediation requires the selection of appropriate plant species and a suitable strategy to be effective. In order to set up an assisted phytoremediation intervention related to a disused industrial site affected by an arsenic and lead complex contamination, an extensive experimental investigation on micro and mesocosm scale has been conducted. Particular attention was given to the choice of plant species: using crop plants (Lupinus albus, Helianthus annuus and Brassica juncea) a series of parallel test campaigns have been realized to investigate different scenarios for the reclamation...
August 10, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28802464/mirage-events-driver-haptic-steering-alerts-in-a-motion-base-driving-simulator-a-method-for-selecting-an-optimal-hmi
#6
Walter Talamonti, Louis Tijerina, Mike Blommer, Radhakrishnan Swaminathan, Reates Curry, R Darin Ellis
This paper describes a new method, a 'mirage scenario,' to support formative evaluation of driver alerting or warning displays for manual and automated driving. This method provides driving contexts (e.g., various Times-To-Collision (TTCs) to a lead vehicle) briefly presented and then removed. In the present study, during each mirage event, a haptic steering display was evaluated. This haptic display indicated a steering response may be initiated to drive around an obstacle ahead. A motion-base simulator was used in a 32-participant study to present vehicle motion cues similar to the actual application...
November 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28802425/outcomes-of-dynamic-hip-screw-augmented-with-trochanteric-wiring-for-treatment-of-unstable-type-a2-intertrochanteric-femur-fractures
#7
Chetan Puram, Chetan Pradhan, Atul Patil, Vivek Sodhai, Parag Sancheti, Ashok Shyam
BACKGROUND: Posteromedial and greater trochanteric fragments are a major cause of telescoping and medialization of the femoral shaft in an unstable intertrochanteric fracture. This leads to significant limb shortening, fracture collapse in varus position and implant failure, which can be prevented by trochanteric wiring in addition to dynamic hip screw (DHS) fixation. The purpose of our study is to assess the outcomes of DHS augmented with trochanteric wiring in unstable type A2 intertrochanteric fractures...
August 2017: Injury
https://www.readbyqxmd.com/read/28802130/trends-in-the-recovery-of-phosphorus-in-bioavailable-forms-from-wastewater
#8
REVIEW
Patrick M Melia, Andrew B Cundy, Saran P Sohi, Peter S Hooda, Rosa Busquets
Addressing food security issues arising from phosphorus (P) scarcity is described as one of the greatest global challenges of the 21st Century. Dependence on inorganic phosphate fertilisers derived from limited geological sources of P creates an urgent need to recover P from wastes and treated waters, in safe forms that are also effective agriculturally - the established process of P removal by chemical precipitation using Fe or Al salts, is effective for P removal but leads to residues with limited bioavailability and contamination concerns...
July 25, 2017: Chemosphere
https://www.readbyqxmd.com/read/28800817/selection-of-reference-genes-to-quantify-relative-expression-of-ochratoxin-a-related-genes-by-penicillium-nordicum-in-dry-cured-ham
#9
Victoria Bernáldez, Juan J Córdoba, María J Andrade, Alberto Alía, Alicia Rodríguez
Penicillium nordicum is an important and consistent producer of ochratoxin A (OTA) in NaCl-rich foods such as dry-cured ham. OTA is a toxic secondary metabolite which provokes negative effects on consumer health. Once OTA is produced in ham, this mycotoxin is difficult to remove. Since gene expression always precedes OTA production, analysis of expression of OTA-related genes by reverse transcription real-time PCR (RT-qPCR) could be a valuable tool to predict OTA contamination in ham. However scarce RT-qPCR protocols are properly validated leading to inconsistent data analyses...
December 2017: Food Microbiology
https://www.readbyqxmd.com/read/28800563/a-novel-polymer-inclusion-membrane-based-method-for-continuous-clean-up-of-thiocyanate-from-gold-mine-tailings-water
#10
Youngsoo Cho, Robert W Cattrall, Spas D Kolev
Thiocyanate is present in gold mine tailings waters in concentrations up to 1000mgL(-1) and this has a serious environmental impact by not allowing water reuse in the flotation of gold ore. This significantly increases the consumption of fresh water and the amount of wastewater discharged in tailings dams. At the same time thiocyanate in tailings waters often leads to groundwater contamination. A novel continuous membrane-based method for the complete clean-up of thiocyanate in concentrations as high as 1000mgL(-1) from its aqueous solutions has been developed...
August 2, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28799457/a-single-institution-experience-for-the-management-of-recurrent-pleural-effusions-with-tunneled-pleural-catheter-and-its-evolution
#11
Tuhina Raman, Nikhil Meena
BACKGROUND: Indwelling tunneled pleural catheters (TPCs) are increasingly being used to treat recurrent pleural effusions. There is also an increased interest in early pleurodesis in order to prevent infectious complications. We studied the time to removal and other outcomes for all the TPCs placed at our institution. METHODS: After institutional review board approval, records of patients who had had a TPC placed between July 2009 and June 2016 were reviewed; the catheters were placed in an endoscopy suite or during pleuroscopy with or without a sclerosant...
August 1, 2017: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/28797899/the-uptake-of-mixed-pahs-and-pbdes-in-wastewater-by-mangrove-plants-under-different-tidal-flushing-regimes
#12
Na Pi, Yan Wu, Hao Wen Zhu, Yuk Shan Wong, Nora Fung Yee Tam
Wastewater often contains mixed toxic pollutants, and the contribution of plant uptake in constructed wetland treatment systems is affected by environmental conditions, particularly tidal flushing. In this study, the uptake of wastewater-borne pollutants, including a mixture of polycyclic aromatic hydrocarbons (PAHs) and polybrominated diphenyl ethers (PBDEs) congeners, by two mangrove plant species, namely Excoecaria agallocha L. and Kandelia obovata Sheue, Liu & Yong, under different tidal flushing regimes was investigated...
August 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28797885/mitophagy-in-neurodegenerative-diseases
#13
REVIEW
Carlo Rodolfo, Silvia Campello, Francesco Cecconi
Neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), and Amyotrophic Lateral Sclerosis (ALS), are a complex "family" of pathologies, characterised by the progressive loss of neurons and/or neuronal functions, leading to severe physical and cognitive inabilities in affected patients. These syndromes, despite differences in the causative events, the onset, and the progression of the disease, share as common features the presence of aggregate-prone neuro-toxic proteins, in the form of aggresomes and/or inclusion bodies, perturbing cellular homeostasis and neuronal function (Popovic et al...
August 7, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28797879/using-a-non-invasive-secure-skin-closure-following-total-knee-arthroplasty-leads-to-fewer-wound-complications-and-no-patient-home-care-visits-compared-to-surgical-staples
#14
Alberto V Carli, Sara Spiro, Brian T Barlow, Steven B Haas
BACKGROUND: Superficial wound complications occur in up to 10% of total knee arthroplasty (TKA) procedures and have been associated with periprosthetic joint infection. The ideal material for TKA closure should offer: 1) fast intraoperative application, 2) minimal wound complications and 3) removable by patients without assistance. We evaluated a novel, non-invasive, removable skin closure system for TKA to determine its effect on wound complications. METHODS: We prospectively evaluated 221 consecutive TKA patients who received skin closure using a non-invasive zipper-like system ('Zip'; Zip 16 Surgical Skin Closure System; Zipline Medical)...
August 7, 2017: Knee
https://www.readbyqxmd.com/read/28797454/impact-of-early-prophylactic-feeding-on-long-term-tube-dependency-outcomes-in-patients-with-head-and-neck-cancer
#15
Teresa Brown, Merrilyn Banks, Brett G M Hughes, Charles Lin, Lizbeth M Kenny, Judith D Bauer
OBJECTIVES: Prophylactic gastrostomy tube (PGT) is frequently used in patients with head and neck cancer (HNSCC). There are concerns this leads to tube dependency but this phenomena is not well defined. This study aimed to determine whether early feeding via PGT impacted on longer term tube feeding outcomes. MATERIALS AND METHODS: Patients with HNSCC with PGT were observed monthly post-treatment regarding tube use and time to removal up to twelve months. Patients were from a randomised controlled trial comparing an early feeding intervention via the PGT (n=57) versus usual care which commenced feeding when clinically indicated (n=67)...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28797210/removal-of-methyl-orange-by-heterogeneous-fenton-catalysts-prepared-using-glycerol-as-green-reducing-agent
#16
Natália S F Trotte, M Alzamora, D R Sánchez, Nakédia M F Carvalho
This study aims to prepare environmentally friendly iron catalysts supported on silica, using glycerol as green reducing and stabilizing agent, for application in heterogeneous Fenton degradation of the pollutant dye methyl orange. The catalysts were characterized by XRD, AAS, SEM, TEM, thermogravimetric analyses, Mössbauer and FTIR spectroscopies, which revealed the formation of iron(II)/(III) oxalates from the oxidation of glycerol by the iron(III) nitrate precursor. Besides, iron oxihydroxide nanoparticles with superparamagnetic behavior were also formed...
August 10, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28796492/structural-and-morphological-description-of-sn-snox-core-shell-nanoparticles-synthesized-and-isolated-from-ionic-liquid
#17
Nadia Soulmi, Damien Dambournet, Cécile Rizzi, Juliette Sirieix-Plénet, Mathieu Duttine, Alain Wattiaux, Jolanta Swiatowska, Olaf J Borkiewicz, Henri Groult, Laurent Gaillon
The potential application of high capacity Sn-based electrode materials for energy storage, particularly in rechargeable batteries, has led to extensive research activities. In this scope, the development of an innovative synthesis route allowing to downsize particles to the nanoscale is of particular interest owing to the ability of such nanomaterial to better accommodate volume changes upon electrochemical reactions. Here, we report on the use of room temperature ionic liquid (i.e., [EMIm(+)][TFSI(-)]) as solvent, template, and stabilizer for Sn-based nanoparticles...
August 10, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28796486/surface-phenomena-during-plasma-assisted-atomic-layer-etching-of-sio2
#18
Ryan James Gasvoda, Alex W van de Steeg, Ranadeep Bhowmick, Eric A Hudson, Sumit Agarwal
Surface phenomena during atomic layer etching (ALE) of SiO2 were studied during sequential half-cycles of plasma assisted fluorocarbon (CFx) film deposition, and Ar plasma activation of the CFx film using in situ surface infrared spectroscopy and ellipsometry. Infrared spectra of the surface after the CFx deposition half-cycle from a C4F8/Ar plasma show that an atomically thin mixing layer is formed between the deposited CFx layer and the underlying SiO2 film. Etching during the Ar plasma cycle is activated by Ar(+) bombardment of the CFx layer, which results in the simultaneous removal of surface CFx and the underlying SiO2 film...
August 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28796116/pain-and-itch-outcome-trajectories-differ-among-european-american-and-african-american-survivors-of-major-thermal-burn-injury
#19
Matthew C Mauck, Jennifer Smith, Jeffrey W Shupp, Mark A Weaver, Andrea Liu, Andrey V Bortsov, Bilal Lateef, Samuel W Jones, Felicia Williams, James Hwang, Rachel Karlnoski, David J Smith, Bruce A Cairns, Samuel A McLean
Over half of individuals experiencing major thermal burn injury (MThBI) receive an autologous skin graft (autograft), in which skin is removed from a healthy "donor" site and transplanted to the burn site. Persistent pain/itch at the graft site are major causes of suffering and disability in MThBI survivors. African Americans have a higher risk of MThBI, and in other clinical settings African Americans experience a greater burden of pain and itch relative to European Americans. However, to our knowledge, ethnic differences in skin graft site pain/itch outcomes after MThBI have not been assessed...
August 8, 2017: Pain
https://www.readbyqxmd.com/read/28795526/coupling-factors-and-exosomal-packaging-micrornas-involved-in-the-regulation-of-bone-remodelling
#20
Sipin Zhu, Felix Yao, Heng Qiu, Ge Zhang, Huazi Xu, Jiake Xu
Bone remodelling is a continuous process by which bone resorption by osteoclasts is followed by bone formation by osteoblasts to maintain skeletal homeostasis. These two forces must be tightly coordinated not only quantitatively, but also in time and space, and its malfunction leads to diseases such as osteoporosis. Recent research focusing on the cross-talk and coupling mechanisms associated with the sequential recruitment of osteoblasts to areas where osteoclasts have removed bone matrix have identified a number of osteogenic factors produced by the osteoclasts themselves...
August 10, 2017: Biological Reviews of the Cambridge Philosophical Society
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