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Cardioplegia

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https://www.readbyqxmd.com/read/27884343/increased-tolerance-to-stress-in-cardiac-expressed-gain-of-function-of-adenosine-triphosphate-sensitive-potassium-channel-subunit-kir6-1
#1
Matthew C Henn, M Burhan Janjua, Haixia Zhang, Evelyn M Kanter, Carol M Makepeace, Richard B Schuessler, Colin G Nichols, Jennifer S Lawton
BACKGROUND: The adenosine triphosphate-sensitive potassium (KATP) channel opener diazoxide (DZX) prevents myocyte volume derangement and reduced contractility secondary to stress. KATP channels are composed of pore-forming (Kir6.1 or Kir6.2) and regulatory (sulfonylurea receptor, SUR1 or SUR2) subunits. Gain of function (GOF) of Kir6.1 subunits has been implicated in cardiac pathology in Cantu syndrome in humans (cardiomegaly, lymphedema, and pericardial effusions). We hypothesized that GOF of Kir6...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27879532/myocardial-protection-and-financial-considerations-of-custodiol-cardioplegia-in-minimally-invasive-and-open-valve-surgery
#2
Brian W Hummel, Randall W Buss, Paul L DiGiorgi, Brittany N Laviano, Nalani A Yaeger, M Lee Lucas, George M Comas
OBJECTIVE: Single-dose antegrade crystalloid cardioplegia with Custodiol-HTK (histidine-tryptophan-ketoglutarate) has been used for many years. Its safety and efficacy were established in experimental and clinical studies. It is beneficial in complex valve surgery because it provides a long period of myocardial protection with a single dose. Thus, valve procedures (minimally invasive or open) can be performed with limited interruption. The aim of this study is to compare the use of Custodiol-HTK cardioplegia with traditional blood cardioplegia in patients undergoing minimally invasive and open valve surgery...
November 22, 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/27847091/avoidance-of-coronary-sinus-injury-during-retrograde-cardioplegia
#3
Kazumasa Orihashi, Kohei Miyashita, Miwa Tashiro, Kazuki Kihara, Nobuo Kondo, Masaki Yamamoto, Nobuyuki Hirose, Takashi Fukutomi, Hideaki Nishimori
Coronary sinus injury is a rare but critical complication of retrograde cardioplegia. Even after detection, successful repair with a pericardial patch is not always attained. Malalignment of the infusion cannula relative to the coronary sinus is likely to be partially responsible for the injury. Monitoring the location of the cannula tip can help prevent injury. Transesophageal echocardiography can indicate the vascular structure within which the cannula is located. This finding may be useful in preventing injury to the coronary sinus or middle cardiac vein...
December 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27815557/whole-body-perfusion-for-hybrid-aortic-arch-repair-evolution-of-selective-regional-perfusion-with-a-modified-extracorporeal-circuit
#4
Philip Fernandes, Graham Walsh, Stephanie Walsh, Michael O'Neil, Jill Gelinas, Michael W A Chu
BACKGROUND: Patients undergoing hybrid aortic arch reconstruction require careful protection of vital organs. We believe that whole body perfusion with tailored dual circuitry may help to achieve optimal patient outcomes. METHODS: Our circuit has evolved from a secondary circuit utilizing a cardioplegia delivery device for lower body perfusion to a dual-oxygenator circuit. This allows individually controlled regional perfusion with ease of switching from secondary to primary circuit for total body flow...
November 3, 2016: Perfusion
https://www.readbyqxmd.com/read/27626269/novel-cardioprotection-strategies-for-the-aged-heart-evidence-from-pre-clinical-studies
#5
Alice E Kane, Susan E Howlett
The incidence of cardiovascular disease is rising as the population ages. This has led to an increase in the need to perform cardiac surgery in older patients. However, aged hearts are particularly susceptible to reperfusion injury following periods of myocardial ischaemia that occur during cardiac surgery. Indeed, older adults experience myocardial dysfunction and reduced survival post-surgery compared to younger people and certain groups, including older women and frail older adults, are at particular risk...
December 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27621853/sufficient-myocardial-protection-of-del-nido-cardioplegia-regardless-of-ventricular-mass-and-myocardial-ischemic-time-in-adult-cardiac-surgical-patients
#6
Ji Seong Kim, Jin Hee Jeong, Sin Ju Moon, Hyuk Ahn, Ho Young Hwang
BACKGROUND: Del Nido (DN) cardioplegic solution (CPS) has been widely used during pediatric cardiac surgery. However, its use in the field of adult cardiac surgery is not popular yet. We evaluated efficacy of DN cardioplegia in adult cardiac surgical patients. METHODS: Fifty-three adult patients (mean age, 54±16 years) who underwent cardiovascular surgery using DN cardioplegia were enrolled. Myocardial troponin I (TnI) level up to three days after surgery and early clinical outcomes were evaluated...
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27607762/ascending-aortic-endoballoon-occlusion-feasible-despite-moderately-enlarged-aorta-to-facilitate-robotic-mitral-valve-surgery
#7
Sarah L Breves, Inki Hong, James McCarthy, Mohammed Kashem, G William Moser, Thomas M Kelley, Erin E Mills, Grayson H Wheatley, T Sloane Guy
OBJECTIVE: Aortic occlusion with an endoballoon is a well-established technique to facilitate robotic and minimally invasive mitral valve surgery. Use of the endoballoon has several relative contraindications including ascending aortic dilatation greater than 38 mm in size. We sought to review our experience using the endoballoon in cases of totally endoscopic mitral valve surgery with aortic diameters greater than 38 mm. METHODS: A retrospective review of our single-site database was conducted to identify patients undergoing totally endoscopic mitral valve surgery by a single surgeon using an endoballoon and who had ascending aortic dilation...
September 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/27578906/whole-blood-cardioplegia-do-we-still-need-to-dilute
#8
Jakob Vinten-Johansen
No abstract text is available yet for this article.
June 2016: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/27578904/del-nido-cardioplegia-not-just-kids-stuff
#9
Linda B Mongero
No abstract text is available yet for this article.
June 2016: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/27578903/del-nido-cardioplegia-elixir-of-choice-for-pediatric-myocardial-protection
#10
Richard M Ginther
No abstract text is available yet for this article.
June 2016: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/27578901/custodiol-cardioplegia-a-single-dose-hyperpolarizing-solution
#11
Claus J Preusse
No abstract text is available yet for this article.
June 2016: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/27578900/the-advanced-myocardial-protection-symposium-contemporary-cardioplegia-strategies-and-outcomes-contemporary-cardioplegia-strategies-and-outcomesfriday-october-9-2015-san-antonio-texas
#12
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/27578898/cold-agglutinin-autoantibodies-in-a-patient-without-a-visible-coronary-sinus-ostium-strategies-for-myocardial-protection-without-using-retrograde-cardioplegia
#13
Michele Heath, Suraj Yalamuri, Julie Walker, Cory Maxwell, Adam Williams, Sharon McCartney, Mani Daneshmand
The presence of cold agglutinins (CA) during cardiac surgery with cardiopulmonary bypass usually creates the need for an altered surgical plan. In this case, the CA were discovered after the initiation of bypass, limiting the time, and cardioplegia solutions that could be used in the new approach. The inability to cannulate the coronary sinus with a retrograde cardioplegia catheter excluded the standard approach to myocardial preservation with CA of using continuous warm blood. For this case, we used intermittent cold crystalloid delivered via the antegrade needle for the first half of the procedure and through the saphenous vein graft anastomosis during the aortic valve portion of the cross-clamp period...
June 2016: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/27578896/del-nido-versus-st-thomas-cardioplegia-solutions-a-single-center-retrospective-analysis-of-post-cross-clamp-defibrillation-rates
#14
Shane T Buel, Carrie Whittaker Striker, James E O'Brien
There are many cardioplegia solutions currently in use for pediatric cardiopulmonary bypass (CPB). The most common being del Nido solution. Another common cardioplegia solution used for pediatric CPB is St. Thomas. In October 2014, Children's Mercy Kansas City changed from the use of modified St. Thomas to del Nido. This study compared rates of post cross-clamp fibrillation requiring defibrillation between del Nido solution and modified St. Thomas solution stratified by weight at Children's Mercy Kansas City...
June 2016: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/27568130/open-aortic-arch-reconstruction-after-coronary-artery-bypass-surgery-worth-the-effort
#15
Eduard Quintana, Pietro Bajona, Hartzell V Schaff, Joseph A Dearani, Richard Daly, Kevin Greason, Alberto Pochettino
Open aortic arch surgery after coronary artery bypass grafting (CABG) is considered a high-risk operation. We reviewed our surgical approach and outcomes to establish the risk profile for this patient population. In methods, from 2000-2014, 650 patients underwent aortic arch surgery with circulatory arrest. Of these, 45 (7%) had previous CABG. Complete medical record was available for review including all preoperative coronary angiograms and detailed management of myocardial protection. In results, the mean interval from previous CABG to aortic arch surgery was 6...
2016: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27565122/use-of-cardioplegia-to-guide-alcohol-ablation-for-incessant-ventricular-tachycardia
#16
Sun Moon Kim, Sebastiano Virgadamo, John Gurley, Claude S Elayi
Incessant scar related re-entrant ventricular tachycardia is an important cause of morbidity and mortality. In patients not amenable to emergent radiofrequency catheter ablation, selective transcoronary alcohol ablation has been successfully performed. In our case study, we introduce the novel use of cardioplegia as a mapping technique for identification of the critical ventricular tachycardia isthmus to guide efficient transcoronary alcohol ablation and prevent unnecessary myocardial damage. This article is protected by copyright...
August 26, 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27526656/impact-of-reperfusion-calcium-and-ph-on-the-resuscitation-of-hearts-donated-after-circulatory-death
#17
Christopher White, Emma Ambrose, Alison Müller, Sanaz Hatami, Yun Li, Hoa Le, James Thliveris, Rakesh Arora, Trevor Lee, Ian Dixon, Ganghong Tian, Jayan Nagendran, Larry Hryshko, Darren Freed
BACKGROUND: Hearts donated after circulatory death may represent an additional donor source. The influx of sodium and calcium ions across the sarcolemma play a central role in the pathogenesis of ischemia-reperfusion injury; however, this process may be inhibited if the initial reperfusion solution is rendered hypocalcemic and acidic. We sought to determine the calcium concentration and pH of the initial reperfusion solution that yielded optimal functional recovery of hearts donated after circulatory death during ex vivo heart perfusion...
August 12, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27521963/carvedilol-enriched-cold-oxygenated-blood-cardioplegia-improves-left-ventricular-diastolic-function-after-weaning-from-cardiopulmonary-bypass
#18
Geir Olav Dahle, Pirjo-Riitta Salminen, Christian Arvei Moen, Finn Eliassen, Else Nygreen, Ville Kytö, Pekka Saukko, Rune Haaverstad, Knut Matre, Ketil Grong
OBJECTIVES: To investigate whether adding carvedilol, a nonselective β- and selective α1-receptor blocking agent with antioxidant properties, to oxygenated blood cardioplegia improves myocardial function after weaning from bypass. DESIGN: A randomized controlled study. SETTING: A university laboratory. PARTICIPANTS: Twenty anesthetized pigs, Norwegian Landrace. INTERVENTIONS: On cardiopulmonary bypass, cardiac arrest was induced with cold (12°C), oxygenated blood cardioplegia, enriched with carvedilol or vehicle, and repeated every 20 minutes...
August 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27513655/potential-beneficial-effect-of-some-adipokines-positively-correlated-with-the-adipose-tissue-content-on-the-cardiovascular-system
#19
REVIEW
Magdalena Sawicka, Joanna Janowska, Jerzy Chudek
Obesity is a risk factor of cardiovascular diseases. However, in the case of heart failure, obese and overweight patients have a more favourable prognosis compared to patients who have a normal body weight. This phenomenon is referred to as the "obesity paradox," and it is explained by, among others, a positive effect of adipokines produced by adipose tissue, particularly by the tissue located in the direct vicinity of the heart and blood vessels. The favourable effect on the cardiovascular system is mostly associated with adiponectin and omentin, but the levels of these substances are reduced in obese patients...
November 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27502137/-clinical-application-of-modified-minimally-cardiopulmonary-bypass-compared-with-conventional-cardiopulmonary-bypass
#20
G Liu, Q D Zeng, Z Zheng, G Y Wang, X L Diao, X Zhang, B Y Ji
OBJECTIVE: To evaluate the safety and effects on blood transfusion of modified minimally cardiopulmonary bypass (CPB). METHODS: From April 2013 to February 2016, 1 103 elective cardiac surgery cases in National Center for Cardiovascular Diseases China, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College were prospectively enrolled in the study. Patients undergoing modified minimally CPB were assigned to mini-CPB group (n=553), the others undergoing conventional CPB were assigned to conventional group (n=550)...
August 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
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