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https://www.readbyqxmd.com/read/27911113/a-tribute-to-professor-steven-l-wechsler-1948-2016-the-man-and-the-scientist
#1
Anthony B Nesburn, Lbachir BenMohamed
Professor Steven L. Wechsler, a world-renowned eye researcher and virologist, passed away unexpectedly on June 12, 2016 at the age of 68. Many scientists came to know Professor Wechsler as a gifted researcher in the field of ocular Herpes Simplex Virus (HSV-1) latency, reactivation, and pathogenesis. Professor Wechsler published over 150 peer-reviewed scientific papers during his career, pushing forward the frontiers of his field eye research. His colleagues would say, 'Steve literally wrote the book on herpes latency and reactivation...
December 2, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27909954/fortifying-the-corrective-nature-of-post-publication-peer-review-identifying-weaknesses-use-of-journal-clubs-and-rewarding-conscientious-behavior
#2
Jaime A Teixeira da Silva, Aceil Al-Khatib, Judit Dobránszki
Most departments in any field of science that have a sound academic basis have discussion groups or journal clubs in which pertinent and relevant literature is frequently discussed, as a group. This paper shows how such discussions could help to fortify the post-publication peer review (PPPR) movement, and could thus fortify the value of traditional peer review, if their content and conclusions were made known to the wider academic community. Recently, there are some tools available for making PPPR viable, either as signed (PubMed Commons) or anonymous comments (PubPeer), or in a hybrid format (Publons)...
December 1, 2016: Science and Engineering Ethics
https://www.readbyqxmd.com/read/27909039/algorithm-for-predicting-death-among-older-adults-in-the-home-care-setting-study-protocol-for-the-risk-evaluation-for-support-predictions-for-elder-life-in-the-community-tool-respect
#3
Amy T Hsu, Douglas G Manuel, Monica Taljaard, Mathieu Chalifoux, Carol Bennett, Andrew P Costa, Susan Bronskill, Daniel Kobewka, Peter Tanuseputro
INTRODUCTION: Older adults living in the community often have multiple, chronic conditions and functional impairments. A challenge for healthcare providers working in the community is the lack of a predictive tool that can be applied to the broad spectrum of mortality risks observed and may be used to inform care planning. OBJECTIVE: To predict survival time for older adults in the home care setting. The final mortality risk algorithm will be implemented as a web-based calculator that can be used by older adults needing care and by their caregivers...
December 1, 2016: BMJ Open
https://www.readbyqxmd.com/read/27908565/determinants-of-hyperhomocysteinemia-in-healthy-and-hypertensive-subjects-a-population-based-study-and-systematic-review
#4
REVIEW
Liyuan Han, Yanfen Liu, Changyi Wang, Linlin Tang, Xiaoqi Feng, Thomas Astell-Burt, Qi Wen, Donghui Duan, Nanjia Lu, Guodong Xu, Kaiyue Wang, Lu Zhang, Kaibo Gu, Sihan Chen, Jianping Ma, Tao Zhang, Dingyun You, Shiwei Duan
AIMS: Hyperhomocysteinemia (HHcy) is known to increase the risk of many diseases. Factors influencing HHcy in healthy and hypertensive subjects remain under-researched. METHODS: A large population-based study was conducted in 60 communities from Shenzhen, China. Responses to standardized questions on lifestyle factors and blood samples were collected from all participants after a 12-h overnight fast. Multiple linear and multivariate logistic regressions were used to explore risk factors for HHcy...
November 19, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27907811/using-the-oases-a-to-illustrate-how-network-analysis-can-be-applied-to-understand-the-experience-of-stuttering
#5
Cynthia S Q Siew, Kristin M Pelczarski, J Scott Yaruss, Michael S Vitevitch
PURPOSE: Network science uses mathematical and computational techniques to examine how individual entities in a system, represented by nodes, interact, as represented by connections between nodes. This approach has been used by Cramer et al. (2010) to make "symptom networks" to examine various psychological disorders. In the present analysis we examined a network created from the items in the Overall Assessment of the Speaker's Experience of Stuttering-Adult (OASES-A), a commonly used measure for evaluating adverse impact in the lives of people who stutter...
November 21, 2016: Journal of Communication Disorders
https://www.readbyqxmd.com/read/27905145/the-public-multi-coil-information-pumcin-policy
#6
Christoph Juchem, Robin A de Graaf
PURPOSE: Multi-coil (MC) magnetic field modeling has emerged as a viable alternative to conventional field generation based on spherical harmonic shapes, and an active MC community is forming. Although all MC applications share the same modeling concept, the specific MC designs can largely differ as a result of disparities in region of interest (eg, human versus rodent), intended MR application (eg, B0 shimming versus spatial encoding), or other experimental constraints (eg, available bore space or integration with radiofrequency technology)...
December 1, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27904637/development-and-initial-psychometric-evaluation-of-the-hospitalization-related-stressors-questionnaire-for-elderly-patients
#7
Zahra Musavi, Mousa Alavi, Nasrollah Alimohammadi, Habibollah Hosseini
BACKGROUND: Various factors threaten the health and recovery of hospitalized elderly, including stressors in medical service centers. Therefore, the aim of the present study was to develop and preliminary validate a measurement tool to assess hospitalization-related stressors (HRS) among the elderly. MATERIALS AND METHODS: This methodological research was conducted in 2015. The study was performed in two main phases. In the first phase, which was to develop the questionnaire, the data were collected through literature review, interview with few elderly patients, and calculating content validity index with the participation of 16 experts...
September 2016: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/27903822/synthetic-biology-and-the-prospects-for-responsible-innovation
#8
REVIEW
Phil Macnaghten, Richard Owen, Roland Jackson
In this article we provide a short review of the debate on responsible innovation and its intersection with synthetic biology, focusing on initiatives we have witnessed and been involved with in the UK. First, we describe the ways in which responsibility in science has been reconfigured institutionally, from an internal focus on the provision of objective and reliable knowledge, to a more external view that embraces the ways in which it has an impact on society. Secondly, we introduce a framework for responsible innovation as a (partial) response to this shift, highlighting its constituent dimensions and the capacities and competencies that are needed to put it into practice...
November 30, 2016: Essays in Biochemistry
https://www.readbyqxmd.com/read/27902580/the-dynamic-mix-of-art-and-science-in-interdisciplinary-team-care-for-community-dwelling-older-adults-with-dementia
#9
Nancy Oliva, Betty Wexler
No abstract text is available yet for this article.
January 2017: Professional Case Management
https://www.readbyqxmd.com/read/27900176/systematic-review-of-physical-activity-and-exercise-interventions-to-improve-health-fitness-and-well-being-of-children-and-young-people-who-use-wheelchairs
#10
Thomas D O'Brien, Jane Noyes, Llinos Haf Spencer, Hans-Peter Kubis, Richard P Hastings, Rhiannon Whitaker
AIM: To perform a systematic review establishing the current evidence base for physical activity and exercise interventions that promote health, fitness and well-being, rather than specific functional improvements, for children who use wheelchairs. DESIGN: A systematic review using a mixed methods design. DATA SOURCES: A wide range of databases, including Web of Science, PubMed, BMJ Best Practice, NHS EED, CINAHL, AMED, NICAN, PsychINFO, were searched for quantitative, qualitative and health economics evidence...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27899658/the-big-data-center-from-deposition-to-integration-to-translation
#11
(no author information available yet)
Biological data are generated at unprecedentedly exponential rates, posing considerable challenges in big data deposition, integration and translation. The BIG Data Center, established at Beijing Institute of Genomics (BIG), Chinese Academy of Sciences, provides a suite of database resources, including (i) Genome Sequence Archive, a data repository specialized for archiving raw sequence reads, (ii) Gene Expression Nebulas, a data portal of gene expression profiles based entirely on RNA-Seq data, (iii) Genome Variation Map, a comprehensive collection of genome variations for featured species, (iv) Genome Warehouse, a centralized resource housing genome-scale data with particular focus on economically important animals and plants, (v) Methylation Bank, an integrated database of whole-genome single-base resolution methylomes and (vi) Science Wikis, a central access point for biological wikis developed for community annotations...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27899147/top-classic-citations-in-pancreatic-cancer-research
#12
Qiang Li, Yuan Jiang
BACKGROUND: The number of times that articles are cited by is widely used to evaluate the impact of an article or an individual author has on its scientific community. This bibliometric analysis aimed to explore the top classic citations in pancreatic cancer (PC) research. METHODS: A computerized literature search was conducted using the database, the Science Citation Index Expanded. The top 100 highly cited articles were included and further analyzed. RESULTS: The most cited article had 3,032 citations, with a mean of 626 citations per paper...
November 29, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27896264/improving-fidelity-of-translation-of-the-stepping-on-falls-prevention-program-through-root-cause-analysis
#13
Jane E Mahoney, Vicki L Gobel, Terry Shea, Jodi Janczewski, Sandy Cech, Lindy Clemson
BACKGROUND: Fidelity monitoring is essential with implementation of complex health interventions, but there is little description of how to use results of fidelity monitoring to improve the draft program package prior to widespread dissemination. Root cause analysis (RCA) provides a systematic approach to identifying underlying causes and devising solutions to prevent errors in complex processes. Its use has not been described in implementation science. METHODS: Stepping On (SO) is a small group, community-based intervention that has been shown to reduce falls by 31%...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27894458/personality-and-global-cognitive-decline-in-japanese-community-dwelling-elderly-people-a-10-year-longitudinal-study
#14
Yukiko Nishita, Chikako Tange, Makiko Tomida, Rei Otsuka, Fujiko Ando, Hiroshi Shimokata
OBJECTIVES: To examine the longitudinal associations between the big five personality and changes in global cognitive function among community-dwelling elderly people involved in the National Institute for Longevity Sciences - Longitudinal Study of Aging. METHODS: The participants were 594 individuals (age range 60-81years) and followed for 10years and tested six times. Personality was assessed by the Japanese version of NEO five factor inventory at baseline. Cognitive function was assessed by the Japanese version of Mini Mental State Examination (MMSE) at all visits...
December 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27891361/serum-frap-levels-and-pre-eclampsia-among-pregnant-women-in-a-rural-community-of-northern-india
#15
Anant Gupta, Shashi Kant, Sanjeev Kumar Gupta, Shyam Prakash, Mani Kalaivani, Chandrakant S Pandav, Sanjay Kumar Rai, Puneet Misra
INTRODUCTION: There is a balance between the oxidative and the anti-oxidative forces in human body. Some studies document decreased level of anti-oxidant in pre-eclampsia while other studies showed normal level of anti-oxidant in pre-eclampsia and the evidence is equivocal. AIM: The aim of the present study was to assess enzymatic anti-oxidant activities in pre-eclamptic women and compare it with normotensive pregnant women with period of gestation between 28 to 36 weeks...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27888993/identifying-biomarkers-for-asthma-diagnosis-using-targeted-metabolomics-approaches
#16
William Checkley, Maria P Deza, Jost Klawitter, Karina M Romero, Jelena Klawitter, Suzanne L Pollard, Robert A Wise, Uwe Christians, Nadia N Hansel
BACKGROUND: The diagnosis of asthma in children is challenging and relies on a combination of clinical factors and biomarkers including methacholine challenge, lung function, bronchodilator responsiveness, and presence of airway inflammation. No single test is diagnostic. We sought to identify a pattern of inflammatory biomarkers that was unique to asthma using a targeted metabolomics approach combined with data science methods. METHODS: We conducted a nested case-control study of 100 children living in a peri-urban community in Lima, Peru...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27885080/importance-of-engaging-in-dialogue-with-the-population-after-a-nuclear-accident
#17
Hans Vanmarcke
Human behaviour is primarily driven by perceptions and this is particularly important in the aftermath of a nuclear accident. One of the main lessons we can draw from the Chernobyl and Fukushima accidents is that once the acute phase of the accident is over, it is important to engage in dialogue with the affected population. Science-based government measures, imposed from above, give rise to much opposition. Examples of this are the aversion of having to live in a contaminated territory, the reluctance of consumers to buy even slightly contaminated food and the opposition of most evacuees to return to their old homes...
November 24, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27885077/highlights-of-the-russian-health-studies-program-and-updated-research-findings
#18
Barrett N Fountos
Recognized for conducting cutting-edge science in the field of radiation health effects research, the Department of Energy's (DOE) Russian Health Studies Program has continued to generate excitement and enthusiasm throughout its 23-year mission to assess worker and public health risks from radiation exposure resulting from nuclear weapons production activities in the former Soviet Union. The three goals of the Program are to: (1) clarify the relationship between health effects and chronic, low-to-medium dose radiation exposure; (2) estimate the cancer risks from exposure to gamma, neutron, and alpha radiation; and (3) provide information to the national and international organizations that determine radiation protection standards and practices...
November 24, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27882453/-implementation-of-a%C3%A2-proactive-integrated-primary-care-program-for-frail-older-people-from-science-to-evidence-based-practice
#19
Nienke Bleijenberg, Artine de Jonge, Morris P Brand, Caitriona O'Flynn, Marieke J Schuurmans, Niek J de Wit
BACKGROUND: Multimorbidity, functional impairment and frailty among community-dwelling older people are causing increasing complexity in primary care. A proactive integrated primary care approach is therefore essential. Between October 2014-2015, an evidence-based proactive care program for frail older people was implemented in the region Noord-West Veluwe en Zeewolde, the Netherlands. This study evaluated the feasibility of the implementation, having a strong focus on the collaboration between the medical and social domain...
December 2016: Tijdschrift Voor Gerontologie en Geriatrie
https://www.readbyqxmd.com/read/27882211/novel-perspectives-on-the-role-of-the-human-microbiota-in-regenerative-medicine-and-surgery
#20
Tommaso Pellegatta, Marco Saler, Viola Bonfanti, Giovanni Nicoletti, Angela Faga
Plastic surgery is transitioning from a fine craftsmanship to a regenerative science. In wound healing, the role of microorganisms is no longer considered to be just counteracting, but also promoting. Furthermore, host-microbe interactions are essential for numerous aspects of normal mammalian physiology, from metabolic activity to immune homeostasis. Each area of the human body hosts a unique microbial community, and the composition of microbiota is dependent on the host, age and the anatomical area, and it changes according to the characteristics of the microenvironment...
November 2016: Biomedical Reports
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