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https://www.readbyqxmd.com/read/29792918/translational-omics-future-potential-and-current-challenges-in-precision-medicine
#1
Arsalan Wafi, Reza Mirnezami
Rapid advances in computational science and biotechnology are paving the way for precision medicine - a vision in next-generation healthcare that promises to provide a care package uniquely tailored to each individual's molecular make-up. Until relatively recently, the focus has been firmly centred around the genome; however, over the past two decades there has been a surge in the study of molecular activity within other biological domains (proteome/transcriptome/metabolome) involved in health and pathogenesis...
May 21, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29792765/exploring-the-relationship-between-volunteering-and-hospice-sustainability-in-the-uk-a-theoretical-model
#2
Ros Scott, Divya Jindal-Snape, Gaye Manwaring
AIM: To explore the relationship between volunteering and the sustainability of UK voluntary hospices. METHODS: A narrative literature review was conducted to inform the development of a theoretical model. Eight databases were searched: CINAHL (EBSCO), British Nursing Index, Intute: Health and Life Sciences, ERIC, SCOPUS, ASSIA (CSA), Cochrane Library and Google Scholar. RESULTS: A total of 90 documents were analysed. Emerging themes included the importance of volunteering to the hospice economy and workforce, the quality of services, and public and community support...
May 2, 2018: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/29792260/widening-participation-of-m%C3%A4-ori-and-pasifika-students-in-health-careers-evaluation-of-two-health-science-academies
#3
Lesley Middleton, Ausaga Faasalele Tanuvasa, Megan Pledger, Nicola Grace, Kirsten Smiler, Tua Taueetia Loto-Su'a, Jacqueline Cumming
Objective The aim of the present study was to evaluate the short-term outcomes of two health science academies established by a district health board in South Auckland, New Zealand, to create a health workforce pipeline for local Māori and Pasifika students. Methods A mixed-methods approach was used, involving background discussions with key informants to generate an initial logic model of how the academies work, followed by secondary analysis of students' records relating to retention and academic achievement, a survey of senior academy students' interest in particular health careers and face-to-face interviews and focus groups with students, families and teachers...
May 24, 2018: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/29792193/research-ethics-review-at-university-eduardo-mondlane-uem-maputo-central-hospital-mozambique-2013-2016-a-descriptive-analysis-of-the-start-up-of-a-new-research-ethics-committee-rec
#4
Jahit Sacarlal, Vasco Muchanga, Carlos Mabutana, Matilde Mabui, Arlete Mariamo, Assa Júlio Cuamba, Leida Artur Fumo, Jacinta Silveira, Elizabeth Heitman, Troy D Moon
BACKGROUND: Mozambique has seen remarkable growth in biomedical research over the last decade. To meet a growing need, the National Committee for Bioethics in Health of Mozambique (CNBS) encouraged the development of ethical review processes at institutions that regularly conduct medical and social science research. In 2012, the Faculty of Medicine (FM) of University Eduardo Mondlane (UEM) and the Maputo Central Hospital (MCH) established a joint Institutional Committee on Bioethics for Health (CIBS FM & MCH)...
May 23, 2018: BMC Medical Ethics
https://www.readbyqxmd.com/read/29791741/diffusing-and-scaling-evidence-based-interventions-eight-lessons-for-early-child-development-from-the-implementation-of-perinatal-home-visiting-in-south-africa
#5
Mark Tomlinson, Xanthe Hunt, Mary Jane Rotheram-Borus
Most low- and middle-income countries lack resources with which to implement public health programs. As such, there is a necessity to facilitate programing that judiciously makes use of what resources there are. However, despite evidence for the efficacy of many interventions, translating these into real-world effectiveness, and then into scalability, is complex and has often been neglected. We draw on a case study of Philani+ (a maternal and child health intervention implemented in South Africa) to distil eight features of health programing that aid intervention effectiveness...
May 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29790989/the-galaxy-platform-for-accessible-reproducible-and-collaborative-biomedical-analyses-2018-update
#6
Enis Afgan, Dannon Baker, Bérénice Batut, Marius van den Beek, Dave Bouvier, Martin Cech, John Chilton, Dave Clements, Nate Coraor, Björn A Grüning, Aysam Guerler, Jennifer Hillman-Jackson, Saskia Hiltemann, Vahid Jalili, Helena Rasche, Nicola Soranzo, Jeremy Goecks, James Taylor, Anton Nekrutenko, Daniel Blankenberg
Galaxy (homepage: https://galaxyproject.org, main public server: https://usegalaxy.org) is a web-based scientific analysis platform used by tens of thousands of scientists across the world to analyze large biomedical datasets such as those found in genomics, proteomics, metabolomics and imaging. Started in 2005, Galaxy continues to focus on three key challenges of data-driven biomedical science: making analyses accessible to all researchers, ensuring analyses are completely reproducible, and making it simple to communicate analyses so that they can be reused and extended...
May 22, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29790942/exposing-the-science-in-citizen-science-fitness-to-purpose-and-intentional-design
#7
Julia K Parrish, Hillary Burgess, Jake F Weltzin, Lucy Fortson, Andrea Wiggins, Brooke Simmons
Citizen science is a growing phenomenon. With millions of people involved and billions of in-kind dollars contributed annually, this broad extent, fine grain approach to data collection should be garnering enthusiastic support in the mainstream science and higher education communities. However, many academic researchers demonstrate distinct biases against the use of citizen science as a source of rigorous information. To engage the public in scientific research, and the research community in the practice of citizen science, a mutual understanding is needed of accepted quality standards in science, and the corresponding specifics of project design and implementation when working with a broad public base...
May 21, 2018: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/29789574/helicobacter-pylori-infected-c57bl-6-mice-with-different-gastrointestinal-microbiota-have-contrasting-gastric-pathology-microbial-and-host-immune-responses
#8
Zhongming Ge, Alexander Sheh, Yan Feng, Sureshkumar Muthupalani, Lili Ge, Chuanwu Wang, Susanna Kurnick, Anthony Mannion, Mark T Whary, James G Fox
C57BL/6 (B6) mice from Taconic Sciences (Tac) and the Jackson Laboratory (Jax) were infected with H. pylori PMSS1 (Hp) for 16 week; there was no significant difference in the gastric histologic activity index between Hp infected Tac and Jax B6. However, the degree of gastric mucous metaplasia and Th1-associated IgG2c levels in response to Hp infection were increased in Tac mice over Jax mice, whereas the colonization levels of gastric Hp were higher by 8-fold in Jax B6 compared with Tac B6. Additionally, mRNA expression of gastric Il-1β, Il-17A and RegIIIγ were significantly lower in the infected Tac compared to the infected Jax mice...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789016/unraveling-bacterial-fingerprints-of-city-subways-from-microbiome-16s-gene-profiles
#9
Alejandro R Walker, Tyler L Grimes, Somnath Datta, Susmita Datta
BACKGROUND: Microbial communities can be location specific, and the abundance of species within locations can influence our ability to determine whether a sample belongs to one city or another. As part of the 2017 CAMDA MetaSUB Inter-City Challenge, next generation sequencing (NGS) data was generated from swipe samples collected from subway stations in Boston, New York City hereafter New York, and Sacramento. DNA was extracted and Illumina sequenced. Sequencing data was provided for all cities as part of 2017 CAMDA contest challenge dataset...
May 22, 2018: Biology Direct
https://www.readbyqxmd.com/read/29787508/impact-of-a-required-service-learning-curriculum-on-preclinical-students
#10
Christopher P Forest, Désirée A Lie
PURPOSE: The impact of brief service-learning curricula on physician assistant (PA) students is not well reported. This study explores student learning immediately and then one to 2 years after a preclinical service-learning experience through written reflections and a survey. METHODS: The 16-hour curriculum within a behavioral science course involved community immersion and engagement with underserved clients. Reflections written by students from 3 consecutive classes were coded for major themes, and theme frequency was assessed...
June 2018: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/29786940/glycoinformatics-bridging-isolated-islands-in-the-sea-of-data
#11
Ksenia S Egorova, Philip V Toukach
Glycoinformatics is a young scientific branch, which assists the scientific community in carbohydrate research. In spite of fundamental roles of glycans in living organisms, the informatization of the field is significantly hindered by the lack of standards, data indices, protocols and tools widely recognized by researchers and publishers. The connection of the existing glycoinformatics projects with each other and with global life-science projects is far from complete. Moreover, in contrast to genes and proteins, there is no obligatory unique identifier for each natural carbohydrate structure...
May 22, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29782219/soft-robotics-academic-insights-and-perspectives-through-bibliometric-analysis
#12
Guanjun Bao, Hui Fang, Lingfeng Chen, Yuehua Wan, Fang Xu, Qinghua Yang, Libin Zhang
Soft robotics is of growing interest in the robot community as well as in public media, and there is an increase in the quality and quantity of publications related to this topic. To formally elaborate this growth, we have used a bibliometric analysis to evaluate the publications in the field from 1990 to 2017 based on the Science Citation Index Expanded database. We present a detailed overview and discussion based on keywords, citation, h-index, year, journal, institution, country, author, and review articles...
May 21, 2018: Soft Robotics
https://www.readbyqxmd.com/read/29781610/sulfur-speciation-in-biochars-by-very-high-resolution-benchtop-k%C3%AE-x-ray-emission-spectroscopy
#13
William Holden, Gerald T Seidler, Singfoong Cheah
The analytical chemistry of sulfur-containing materials poses substantial technical challenges, especially due to the limitations of 33S NMR and the time-intensive preparations required for wet-chemistry analyses. A number of prior studies have found that synchrotron-based x-ray absorption near edge structure (XANES) measurements can give detailed speciation of sulfur chemistry in such cases. However, due to the obvious access limitations, synchrotron XANES of sulfur cannot be part of routine analytical practice across the chemical sciences community...
May 21, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29781310/when-the-research-is-not-reproducible-the-importance-of-author-initiated-and-institution-driven-responses-and-investigations
#14
Bor Luen Tang
Important and potentially useful findings in the sciences are under more intense public scrutiny now more than ever. Other researchers in the field dive into replicating and expanding the findings while the media swamps the community and the public with peripheral reporting and analyses. How should authors and the hosting/funding institutions respond when other workers in the field could not reproduce or replicate their published results? To illustrate the importance of author-initiated and institution-driven investigations in response to outcries of research irreproducibility, I draw on comparisons between three recent and well-publicized cases in the life sciences: betatrophin, STAP cells, and NgAgo...
May 20, 2018: Accountability in Research
https://www.readbyqxmd.com/read/29780742/caries-risk-assessment-of-12-13-year-old-government-and-private-school-going-children-of-mysore-city-using-cariogram-a-comparative-study
#15
Sandhya P Naik, Shabna Moyin, Bhakti Patel, Lata Prabhu Warad, Sameer Punathil, C B Sudeep
Aim: The aim of this study is to assess the caries risk assessment of 12-13-year-old government and private school going children of Mysore city using Cariogram. Materials and Methods: A cross-sectional examination was carried out on a total of 104 government and private schoolchildren aged 12-13 years. Ten factors from the Cariogram software(D Bratthall, Computer software, Malmo, Sweden) were included from study participant's records to complete the Cariogram. The percentage of "chances of avoiding new lesions" (caries risk) among government and private school study participants were obtained from Cariogram, and the participants were classified into five risk groups...
March 2018: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29780544/the-enhancement-and-suppression-of-immersion-mode-heterogeneous-ice-nucleation-by-solutes
#16
Thomas F Whale, Mark A Holden, Theodore W Wilson, Daniel O'Sullivan, Benjamin J Murray
Heterogeneous nucleation of ice from aqueous solutions is an important yet poorly understood process in multiple fields, not least the atmospheric sciences where it impacts the formation and properties of clouds. In the atmosphere ice-nucleating particles are usually, if not always, mixed with soluble material. However, the impact of this soluble material on ice nucleation is poorly understood. In the atmospheric community the current paradigm for freezing under mixed phase cloud conditions is that dilute solutions will not influence heterogeneous freezing...
May 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780026/teaching-the-relationship-between-health-and-climate-change-a-systematic-scoping-review-protocol
#17
Tasnime Osama, David Brindley, Azeem Majeed, Kris A Murray, Hiral Shah, Mel Toumazos, Michelle Van Velthoven, Josip Car, Glenn Wells, Edward Meinert
INTRODUCTION: The observed and projected impacts of climate change on human health are significant. While climate change has gathered global momentum and is taught frequently, the extent to which the relationships between climate change and health are taught remains uncertain. Education provides an opportunity to create public engagement on these issues, but the extent to which historical implementation of climate health education could be leveraged is not well understood. To address this gap, we propose to conduct a scoping review of all forms of teaching that have been used to illustrate the health effects of climate change between 2005 and 2017, coinciding with a turning point in the public health and climate change agendas following the 2005 Group of 7/8 (G7/8) Summit...
May 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29779253/community-based-native-seed-production-for-restoration-in-brazil-the-role-of-science-and-policy
#18
Isabel B Schmidt, Danilo I de Urzedo, Fatima C M Piña-Rodrigues, Daniel L M Vieira, Gustavo M de Rezende, Alexandre B Sampaio, Rodrigo G P Junqueira
Large-scale restoration programs in the tropics require large volumes of high quality, genetically diverse and locally adapted seeds from large number of species. However, scarcity of native seeds is a critical restriction to achieve restoration targets. In this paper, we analyze three successful community-based networks that supply native seeds and seedlings for Brazilian Amazon and Cerrado restoration projects. In addition, we propose directions to promote local participation, legal, technical and commercialization issues for upscaling the market of native seeds for restoration with high quality and social justice...
May 20, 2018: Plant Biology
https://www.readbyqxmd.com/read/29776136/individual-heterogeneity-generating-explosive-system-network-dynamics
#19
Pedro D Manrique, Neil F Johnson
Individual heterogeneity is a key characteristic of many real-world systems, from organisms to humans. However, its role in determining the system's collective dynamics is not well understood. Here we study how individual heterogeneity impacts the system network dynamics by comparing linking mechanisms that favor similar or dissimilar individuals. We find that this heterogeneity-based evolution drives an unconventional form of explosive network behavior, and it dictates how a polarized population moves toward consensus...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29774547/petunia-as-model-for-elucidating-adventitious-root-formation-and-mycorrhizal-symbiosis-at-the-nexus-of-physiology-genetics-microbiology-and-horticulture
#20
Uwe Druege, Philipp Franken
Adventitious root formation in cuttings and establishment of arbuscular mycorrhizal symbiosis reflect the enormous plasticity of plants and are key factors in the efficient and sustainable clonal propagation and production of ornamental crops. Based on the high importance of Petunia hybrida for the European and US annual bedding plant markets and its suitability as a model for basic plant sciences, petunia has been established as an experimental system for elucidating the molecular and physiological processes underlying adventitious root formation and mycorrhizal symbiosis...
May 17, 2018: Physiologia Plantarum
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