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https://www.readbyqxmd.com/read/29055163/microbial-sensor-for-drug-susceptibility-testing-of-mycobacterium-tuberculosis
#1
Zhi-Tao Zhang, Dian-Bing Wang, Chuan-You Li, Jiao-Yu Deng, Ji-Bin Zhang, Li-Jun Bi, Xian-En Zhang
AIMS: Drug susceptibility testing (DST) of clinical isolates of Mycobacterium tuberculosis (M. tuberculosis) is critical in treating tuberculosis. We demonstrate the possibility of using a microbial sensor to perform DST of M. tuberculosis and shorten the time required for DST. METHODS AND RESULTS: The sensor is made of an oxygen electrode with M. tuberculosis cells attached to its surface. This sensor monitors the residual oxygen consumption of M. tuberculosis cells after treatment with anti-TB drugs with glycerine as a carbon source...
October 21, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29055040/the-concise-guide-to-pharmacology-2017-18-g-protein-coupled-receptors
#2
Stephen Ph Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055039/the-concise-guide-to-pharmacology-2017-18-other-ion-channels
#3
Stephen Ph Alexander, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055038/the-concise-guide-to-pharmacology-2017-18-ligand-gated-ion-channels
#4
Stephen Ph Alexander, John A Peters, Eamonn Kelly, Neil V Marrion, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055037/the-concise-guide-to-pharmacology-2017-18-overview
#5
Stephen Ph Alexander, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, O Peter Buneman, John A Cidlowski, Arthur Christopoulos, Anthony P Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055036/the-concise-guide-to-pharmacology-2017-18-catalytic-receptors
#6
Stephen Ph Alexander, Doriano Fabbro, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055035/the-concise-guide-to-pharmacology-2017-18-transporters
#7
Stephen Ph Alexander, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055034/the-concise-guide-to-pharmacology-2017-18-enzymes
#8
Stephen Ph Alexander, Doriano Fabbro, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055033/the-concise-guide-to-pharmacology-2017-18-voltage-gated-ion-channels
#9
Stephen Ph Alexander, Jörg Striessnig, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055032/the-concise-guide-to-pharmacology-2017-18-nuclear-hormone-receptors
#10
Stephen Ph Alexander, John A Cidlowski, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29054830/epidemiology-of-hepatitis-c-virus-among-people-who-inject-drugs-protocol-for-a-systematic-review-and-meta-analysis
#11
Daniel J Smith, Josh Neurer, Ashly E Jordan, Holly Hagan
BACKGROUND: Hepatitis C virus (HCV) is a persistent epidemic among people who inject drugs (PWID), and PWID remain as the population experiencing the most significant impact of HCV-related morbidity and mortality worldwide. OBJECTIVE: The purpose of this systematic review and meta-analysis is to synthesize data on the epidemiology of HCV infection among PWID. Our main objectives are to characterize the global and regional distribution and determinants of HCV infection among PWID...
October 20, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29054519/nature-derived-scaffolds-for-tissue-engineering-applications-design-and-fabrication-of-a-composite-scaffold-incorporating-chitosan-g-d-l-lactic-acid-and-cellulose-nanocrystals-from-lactuca-sativa-l-cv-green-leaf
#12
Sung Won Ko, Juan Paolo E Soriano, Ji Yeon Lee, Afeesh Rajan Unnithan, Chan Hee Park, Cheol Sang Kim
Through exhaustive extraction via successive alkali and bleaching treatments cellulose was isolated from lettuce. The isolated cellulose was hydrolyzed using 64wt% H2SO4 at 55°C under constant stirring for 1h to obtain cellulose nanocrystals (CNCs). Characterizations such as SEM, TEM, FTIR, TGA and XRD were done in order to determine differences in the physico-chemical characteristics of cellulose after each treatment step. The isolated CNCs have mean dimensions of 237±26, 33±12 and 32±7nm in length, thickness and height, respectively...
October 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29054292/addiction-a-dysregulation-of-satiety-and-inflammatory-processes
#13
Rivona Harricharan, Oualid Abboussi, William M U Daniels
Over the years, drug addiction has proven to be a perplexing conundrum for scientists. In attempts to decipher the components of the puzzle, multiple theories of addiction have been proposed. While these theories have assisted in providing essential fundamental information, current research recommends that a new theory needs to be presented taking into consideration the results of recent developments in the fields of neuroimmunology, genetics, and neuropsychiatry. After extensively examining the published literature, we propose in this review that neuroinflammation and hypothalamic functioning strongly underpin addictive behavior...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/29054291/neuroscience-informed-psychoeducation-for-addiction-medicine-a-neurocognitive-perspective
#14
Hamed Ekhtiari, Tara Rezapour, Robin L Aupperle, Martin P Paulus
Psychoeducation (PE) is defined as an intervention with systematic, structured, and didactic knowledge transfer for an illness and its treatment, integrating emotional and motivational aspects to enable patients to cope with the illness and to improve its treatment adherence and efficacy. PE is considered an important component of treatment in both medical and psychiatric disorders, especially for mental health disorders associated with lack of insight, such as alcohol and substance use disorders (ASUDs). New advancements in neuroscience have shed light on how various aspects of ASUDs may relate to neural processes...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/29054274/seventeen-year-nationwide-trends-in-antihypertensive-drug-use-in-denmark
#15
Jens Sundbøll, Kasper Adelborg, Kathryn E Mansfield, Laurie A Tomlinson, Morten Schmidt
Recent trends in use of antihypertensive drugs are unknown. From Danish nationwide prescription data, we obtained information on primary care use of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta blockers, diuretics, aldosterone receptor antagonists, and calcium channel blockers. During 1999 to 2015, the use of antihypertensive drugs per 1,000 inhabitants/day increased from 184 to 379 defined daily doses (DDD), corresponding to a rise in the prevalence proportion of users from ≈20% to ≈35%...
September 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29054256/drug-target-interaction-prediction-a-bayesian-ranking-approach
#16
Ladislav Peska, Krisztian Buza, Júlia Koller
BACKGROUND AND OBJECTIVE: In silico prediction of drug-target interactions (DTI) could provide valuable information and speed-up the process of drug repositioning - finding novel usage for existing drugs. In our work, we focus on machine learning algorithms supporting drug-centric repositioning approach, which aims to find novel usage for existing or abandoned drugs. We aim at proposing a per-drug ranking-based method, which reflects the needs of drug-centric repositioning research better than conventional drug-target prediction approaches...
December 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29054033/hepatitis-c-antibody-prevalence-among-mexico-city-prisoners-injecting-legal-and-illegal-substances
#17
Omar Silverman-Retana, Edson Serván-Mori, Sandra I McCoy, Sarah Larney, Sergio Bautista-Arredondo
BACKGROUND: Hepatitis C virus (HCV) infection is highly prevalent among prisoners and this prevalence estimates reach 64% among prisoners who inject illicit drugs. Prisons are important sites for HCV transmission in the absence of access to sterile injecting equipment; hence, it can be transmitted between prisoners who share contaminated needles and syringes. We aimed to estimate the prevalence of risk factors for anti-HCV prevalence, with particular interest on injecting behavior, and to assess correlates of anti-HCV positivity among Mexico City prisoners...
October 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29054031/mental-health-of-heroin-users-with-differing-injection-drug-use-histories-a-non-treatment-sample-of-mexican-american-young-adult-men
#18
Kathryn M Nowotny, Tasha Perdue, Alice Cepeda, Avelardo Valdez
BACKGROUND: While the comorbidity of mental health and injecting heroin has been documented, current research is limited by describing the mental health of people who inject drugs without a comparison group and by the lack of research on nontreatment samples in the United States, particularly among Hispanics. The purpose of this study was to examine the association of injecting history (never, former, occasional, and daily) and multiple outcomes of global and mental health using a sample of U...
October 7, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29053865/beta-burst-dynamics-in-parkinson-s-disease-off-and-on-dopaminergic-medication
#19
Gerd Tinkhauser, Alek Pogosyan, Huiling Tan, Damian M Herz, Andrea A Kühn, Peter Brown
Exaggerated basal ganglia beta activity (13-35 Hz) is commonly found in patients with Parkinson's disease and can be suppressed by dopaminergic medication, with the degree of suppression being correlated with the improvement in motor symptoms. Importantly, beta activity is not continuously elevated, but fluctuates to give beta bursts. The percentage number of longer beta bursts in a given interval is positively correlated with clinical impairment in Parkinson's disease patients. Here we determine whether the characteristics of beta bursts are dependent on dopaminergic state...
October 10, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053436/is-the-danish-version-of-mate-feasible-a-pilot-study-on-feasibility-and-adequacy
#20
Morten Ellegaard Hell, Kjeld Andersen, Anette Søgaard Nielsen
OBJECTIVE: Assessment is pivotal to the work of healthcare professionals and social workers as it provides fundamental, systematic information that is essential when planning interventions. Many patients have addiction problems as well as psychiatric illness and they very often interact. An assessment tool addressing both areas would be beneficial for this large group of patients. This pilot study explores feasibility and adequacy of the Danish translation of the Measurements in Addiction for Triage and Evaluation (MATE) assessment in the following sectors: drug- and alcohol treatment, psychiatry and social service...
October 20, 2017: Journal of Dual Diagnosis
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