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Hepatic sarcoidosis

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https://www.readbyqxmd.com/read/28298841/etiological-profile-of-noncompressive-myelopathies-in-a-tertiary-care-hospital-of-northeast-india
#1
Ashok Kumar Kayal, Munindra Goswami, Marami Das, Lakhshya Jyoti Basumatary, Suvorit Subhas Bhowmick, Baiakmenlang Synmon
BACKGROUND: The discovery of antibodies against aquaporin-4 and evolving concepts of noncompressive myelopathies in the 21(st) century have made a major impact on the etiological profile of these diseases, with few cases turning out to be idiopathic. OBJECTIVE: To find causes of noncompressive myelopathy in a tertiary care hospital of Northeast India. MATERIALS AND METHODS: An observational study was carried out in the Neurology Department of Gauhati Medical College, Guwahati, from September 2013 to February 2016...
January 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28280650/polycystic-liver-disease-and-sarcoidosis-unusual-coexisting-etiologies-of-portal-hypertension
#2
Waseem Amjad, Sophia Jagroop, Rukma Parthvi
Both polycystic liver disease (PLD) and sarcoidosis can involve liver. Most of the time, liver disease in both conditions is asymptomatic, but they can rarely cause portal hypertension. Our aim is to report a case of a 51-year-old female with a history of adult dominant polycystic kidney disease (ADPKD) and sarcoidosis who presented with multiple episodes of hematemesis. An endoscopy showed grade 3 esophageal varices. A computed tomography (CT) scan of the abdomen showed ascites with polycystic liver, nodular contour, and calcified granuloma...
January 25, 2017: Curēus
https://www.readbyqxmd.com/read/28121924/autoimmune-diseases-and-hiv-infection-a-cross-sectional-study
#3
Emilie Virot, Antoine Duclos, Leopold Adelaide, Patrick Miailhes, Arnaud Hot, Tristan Ferry, Pascal Seve
To describe the clinical manifestations, treatments, prognosis, and prevalence of autoimmune diseases (ADs) in human immunodeficiency virus (HIV)-infected patients.All HIV-infected patients managed in the Infectious Diseases Department of the Lyon University Hospitals, France, between January 2003 and December 2013 and presenting an AD were retrospectively included.Thirty-six ADs were found among 5186 HIV-infected patients which represents a prevalence of 0.69% including immune thrombocytopenic purpura (n = 15), inflammatory myositis (IM) (n = 4), sarcoidosis (n = 4), Guillain-Barré syndrome (GBS) (n = 4), myasthenia gravis (n = 2), Graves' disease (n = 2), and 1 case of each following conditions: systemic lupus erythematosus, rheumatoid arthritis, autoimmune hepatitis, Hashimoto thyroiditis and autoimmune hemolytic anemia...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27981598/anti-tnf-%C3%AE-for-necrotizing-sarcoid-granulomatosis-of-the-liver
#4
Marcial Sebode, Sören Weidemann, Malte Wehmeyer, Ansgar W Lohse, Christoph Schramm
We present a case of hepatosplenic necrotizing sarcoid granulomatosis, a variant form of "classical" sarcoidosis, that became clinically apparent in the form of multiple hepatic and splenic masses mimicking malignancy. Flow cytometry of intrahepatic T cells isolated from liver biopsy led to the targeted treatment with anti-tumor necrosis factor-alpha, which was highly effective in inducing remission. (Hepatology 2017;65:1410-1412).
April 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27904945/-sarcoidosis-and-uveitis-an-update
#5
REVIEW
J G Garweg
Ocular involvement in sarcoidosis is present in up to one third of patients and is frequently manifested before the underlying systemic disease has been diagnosed. With a view to the therapeutic consequences an early diagnosis of the underlying disease is advantageous. In cases of visual loss early diagnostic measures include invasive procedures, such as ultrasound-guided bronchoalveolar lavage and transbronchial biopsy, if nodular conjunctival or cutaneous manifestations which would confirm the diagnosis are not present...
November 30, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27795804/hepatic-sarcoidosis-a-case-series
#6
Rym Ennaifer, Shema Ayadi, Hayfa Romdhane, Myriam Cheikh, Houda Ben Nejma, Wassila Bougassas, Najet Bel Hadj
Sarcoidosis is a systemic non caseous granulomas disease. Liver is a common location but usually asymptomatic. Evidence based guidelines for this location treatment is lacking and the effect of corticosteroids may be inadequate. The aim of our study was to describe the clinical, biochemical, radiological and therapeutic features of seven patients with systemic sarcoidosis and liver involvement. A retrospective and descriptive monocentric study, over 3 years, including seven patients with systemic sarcoidosis and liver involvement...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27758994/causes-of-death-in-patients-with-chronic-sarcoidosis
#7
Xiaowen Hu, Eva M Carmona, Eunhee S Yi, Patricia A Pellikka, Jay Ryu
INTRODUCTION: Sarcoidosis is a multi-system, granulomatous disorder of unknown etiology that is associated with a variable prognosis and sometimes results in death. There are conflicting reports regarding the causes of death in patients with sarcoidosis. METHODS: Forty-four consecutive patients with sarcoidosis who underwent an autopsy (35 patients) or died at Mayo Clinic (Rochester, MN, USA) over a 20-yr period, from January 1, 1994 to December 31, 2013 were analyzed...
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27748327/pediatric-gastrointestinal-sarcoidosis-successful-treatment-with-infliximab
#8
Laila Alawdah, Ahmad Nahari, Dayel Alshahrani, Musa Fagih, Shahid Ghazi, Abdulrahman Al-Hussaini
Gastrointestinal sarcoidosis is a rare disease with very limited data in children. Here we report the first pediatric case of successful treatment with infliximab. The first case was an 8-year-old Saudi girl who presented with fever, weight loss, and abdominal pain that was followed in a few months with hematemesis and development of hepatosplenomegaly. The second case was a 9-year-old Sudanese boy who manifested with vomiting, epigastric pain, and weight loss. On upper endoscopy, both cases demonstrated severe erosive nodular gastric mucosa...
September 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27721768/prostate-specific-membrane-antigen-pet-ct-false-positive-results-due-to-sarcoidosis
#9
Robert M Hermann, Manoutschehr Djannatian, Norbert Czech, Mirko Nitsche
We report on a 72-year-old male patient who developed sarcoidosis of the mediastinal lymph nodes, the liver, and the prostate 11 years ago. Seven years later, he underwent transurethral resection of the prostate by laser due to hematuria. Pathology of the resected chips showed a 'granulomatous prostatitis with epitheloid cells'. Malignancy was histologically excluded at that time. Four years later, he was diagnosed with an undifferentiated prostate carcinoma, with a Gleason score of 5 + 4 = 9. After initiation of antihormonal therapy, he underwent radical prostatectomy and pelvic lymphadenectomy, which revealed a pT3b pN1 carcinoma with infiltrated resection margins...
May 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27544391/kaleidoscope-of-autoimmune-diseases-in-hiv-infection
#10
REVIEW
Justyna Roszkiewicz, Elzbieta Smolewska
Within the last 30 years, the human immunodeficiency virus (HIV) infection has changed its status from inevitably fatal to chronic disorder with limited impact on life span. However, this breakthrough was mainly the effect of introduction of the aggressive antiviral treatment, which has led to the clinically significant increase in CD4+ cell count, resulting in fewer cases of the acquired immunodeficiency syndrome (AIDS) and improved management of opportunistic infections occurring in the course of the disease...
November 2016: Rheumatology International
https://www.readbyqxmd.com/read/27493456/long-term-outcomes-of-liver-transplantation-for-hepatic-sarcoidosis-a-single-center-experience
#11
Muhammad Bilal, Sanjaya K Satapathy, Mohammad K Ismail, Jason M Vanatta
AIM: Hepatic sarcoidosis is a rare indication for orthotopic liver transplantation (OLT). Hence, studies evaluating these patients are scarce. We present a single center experience with OLT for hepatic sarcoidosis in a case-control study. METHODS: A retrospective chart review was performed on 970 patients with OLT at our center, and 13 patients (1.3%) were identified who underwent 14 OLTs for hepatic sarcoidosis. For each case, two controls matched for etiology of liver disease, recipient age (±5 years), and duration since transplant (within 5 years) were selected...
June 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27472273/adverse-events-associated-with-immune-checkpoint-blockade-in-patients-with-cancer-a-systematic-review-of-case-reports
#12
Noha Abdel-Wahab, Mohsin Shah, Maria E Suarez-Almazor
BACKGROUND: Three checkpoint inhibitor drugs have been approved by the US Food and Drug Administration for use in specific types of cancers. While the results are promising, severe immunotherapy-related adverse events (irAEs) have been reported. OBJECTIVES: To conduct a systematic review of case reports describing the occurrence of irAEs in patients with cancer following checkpoint blockade therapy, primarily to identify potentially unrecognized or unusual clinical findings and toxicity...
2016: PloS One
https://www.readbyqxmd.com/read/27424016/secondary-sjogren-s-syndrome-in-83-patients-with-rheumatoid-arthritis
#13
Asghar Hajiabbasi, Irandokht Shenavar Masooleh, Yousef Alizadeh, Amir Sadredin Banikarimi, Pooneh Ghavidel Parsa
UNLABELLED: Sjogren syndrome (SS) can occur alone, primary Sjogren syndrome, or in association with other rheumatic diseases, secondary Sjogren syndrome (sSS), such as Rheumatoid arthritis (RA). The occurrence of Sjogren syndrome with RA makes it course worse and increases high morbidity and mortality of RA. In this exploratory study we aim to determine the prevalence of sSS (diagnosed based on the revised version of American-European consensus Group Classification Criteria: AUCG-criteria), sicca symptoms (dry eye, dry mouth), positive autoantibody tests (Anti RO or Anti-LA antibodies), UWSFR (Unstimulated Whole Salivary Flow Rate), Schirmer and Lissamine test...
July 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/27200114/-budd-chiari-syndrome-a-rare-complication-of-hepatic-sarcoidosis-about-one-case
#14
Ismael Ait Sghier, Nabil Moatassim Billah
Sarcoidotic involvement of the liver is frequent, albeit uncommonly symptomatic. Anicteric cholestasis and portal hypertension are the main complications. Budd-Chiari syndrome is a little known and exceptional complication of hepatic sarcoidosis. We present a case of A 45-year-old woman suffering from hepatic sarcoidosis who developed Budd-Chiari syndrome.
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27192527/sarcoidosis-and-chronic-hepatitis-c-treatment-with-prednisone-and-colchicine
#15
Eduardo Guimarães Pereira, Tais Ferreira Guimarães, Caroline Bertolini Bottino, Antonio Macedo D'Acri, Ricardo Barbosa Lima, Carlos José Martins
Sarcoidosis is a disease which still has uncertain etiology. Possible environmental causes are cited in the literature, like organic and inorganic particles and infectious agents. Recent studies have demonstrated the occurrence of sarcoidosis in patients with chronic C hepatitis; however, this association remains without statistical or causal evidence. In this report a case of sarcoidosis associated with chronic hepatitis C will be described, with subcutaneous lesions, considered rare, and good response to treatment with colchicine and prednisone...
April 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27175775/hepatic-sarcoidosis-pathogenesis-clinical-context-and-treatment-options
#16
Umer Syed, Hassan Alkhawam, Mena Bakhit, Rafael A Ching Companioni, Aron Walfish
Sarcoidosis is typically characterized as a non-caseating granulomatous disease that has the ability to affect multiple different organ systems. Although extra-thoracic sarcoidosis can occur in the presence and also without lung involvement, isolated extra-pulmonary disease is rare. The liver is the third most commonly affected organ system after the lungs and lymph nodes. When discussing hepatic sarcoidosis it is important to keep in mind that many patients in this population may not present as one would typically expect since most of the patients are asymptomatic or have mild presentations...
September 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27161792/sarcoidosis-developing-after-treatment-with-interferon-alpha-in-a-patient-with-hepatitis-c-an-association-every-physician-should-know
#17
B J Flores-Robles, C P Sangüesa-Gómez, C Barbadillo Mateos, L G Roustán-Gullón, I Kovtun
No abstract text is available yet for this article.
May 5, 2016: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/27150448/development-of-hypercalcemia-in-a-patient-receiving-peginterferon-alfa-2a-therapy-for-polycythemia-vera
#18
Sheetal Karne, Candace B Mainor, Maria R Baer
Peginterferon alfa-2a (PEG-IFN alfa-2a) is commonly used to treat hepatitis C virus infection and is also being used increasingly to treat myeloproliferative neoplasms including polycythemia vera. Sarcoidosis associated with interferon therapy for treatment of hepatitis C is well described, with hypercalcemia occurring as a rare manifestation. We describe a 25-year-old man with polycythemia vera who became resistant to hydroxyurea after 6 years of treatment, requiring therapeutic phlebotomy procedures with increasing frequency for increased hemoglobin and hematocrit levels...
May 6, 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27010096/a-case-of-human-immunodeficiency-virus-infection-with-cerebellar-ataxia-that-suggested-by-an-association-with-autoimmunity
#19
Shigeto Nagao, Takayuki Kondo, Takashi Nakamura, Tomokazu Nakagawa, Sadayuki Matsumoto
We report a case of human immunodeficiency virus (HIV) infection that showed subacute progressive cerebellar ataxia without HIV encephalopathy or other encephalopathies, including progressive multifocal leukoencephalopathy or encephalitis of other human herpes virus (HHV) infections. A 43-year-old man exhibited unsteady gait. Neurological examination disclosed ataxia of the trunk and lower extremities. Personality change and dementia were absent. Magnetic resonance imaging did not reveal any abnormal finding, including of the cerebellum...
April 28, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/26988383/-livedo-like-cutaneous-sarcoidosis
#20
S Duboys, V Cante, C Monégier du Sorbier, G Guillet
BACKGROUND: The cutaneous signs of sarcoidosis are extremely polymorphous and may be classified under several different headings. PATIENTS AND METHODS: Herein, we report the case of a 51-year-old female patient presenting bilateral livedo of the knees accompanied by systemic signs with polyarthralgia, impaired general state of health, weight loss, and a sensation of dyspnoea. Skin biopsy revealed giant-cell granuloma around the dermal vessels, with no caseous necrosis...
May 2016: Annales de Dermatologie et de Vénéréologie
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