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https://www.readbyqxmd.com/read/29146865/echocardiographic-changes-with-non-invasive-ventilation-and-cpap-in-obesity-hypoventilation-syndrome
#1
Jaime Corral, Maria Victoria Mogollon, M-Ángeles Sánchez-Quiroga, Javier Gómez de Terreros, Auxiliadora Romero, Candela Caballero, Joaquin Teran-Santos, María L Alonso-Álvarez, Teresa Gómez-García, Mónica González, Soledad López-Martínez, Pilar de Lucas, José M Marin, Odile Romero, Trinidad Díaz-Cambriles, Eusebi Chiner, Carlos Egea, Roberto M Lang, Babak Mokhlesi, Juan F Masa
RATIONALE: Despite a significant association between obesity hypoventilation syndrome (OHS) and cardiac dysfunction, no randomised trials have assessed the impact of non-invasive ventilation (NIV) or CPAP on cardiac structure and function assessed by echocardiography. OBJECTIVES: We performed a secondary analysis of the data from the largest multicentre randomised controlled trial of OHS (Pickwick project, n=221) to determine the comparative efficacy of 2 months of NIV (n=71), CPAP (n=80) and lifestyle modification (control group, n=70) on structural and functional echocardiographic changes...
November 16, 2017: Thorax
https://www.readbyqxmd.com/read/29141301/-obstructive-sleep-apnea-hypopnea-syndrome-complicated-with-obesity-hypoventilation-syndrome-a-case-report
#2
Z Y Zhang, H H Lu, Q W Li, P Lin
No abstract text is available yet for this article.
November 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29129174/high-flow-or-titrated-oxygen-for-obese-medical-inpatients-a-randomised-crossover-trial
#3
Janine Pilcher, Michael Richards, Leonie Eastlake, Steven J McKinstry, George Bardsley, Sarah Jefferies, Irene Braithwaite, Mark Weatherall, Richard Beasley
OBJECTIVE: To compare the effects on transcutaneous carbon dioxide tension (Ptco2) of high concentration and titrated oxygen therapy in medical inpatients with morbid obesity who were not selected for a pre-existing diagnosis of obesity hypoventilation syndrome. DESIGN: A randomised, crossover trial undertaken between February and September 2015. SETTING: Internal medicine service, Wellington Regional Hospital, New Zealand. PARTICIPANTS: 22 adult inpatients, aged 16 years or more, with a body mass index exceeding 40 kg/m<sup>2</sup>...
November 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29116603/leigh-syndrome-in-individuals-bearing-m-9185t-c-mtatp6-variant-is-hyperventilation-a-factor-which-starts-its-development
#4
Dorota Piekutowska-Abramczuk, Rafał Rutyna, Elżbieta Czyżyk, Elżbieta Jurkiewicz, Katarzyna Iwanicka-Pronicka, Dariusz Rokicki, Sylwia Stachowicz, Joanna Strzemecka, Wiesław Guz, Michał Gawroński, Aneta Kosierb, Joanna Ligas, Mateusz Puchala, Anna Drelich-Zbroja, Małgorzata Bednarska-Makaruk, Wojciech Dąbrowski, Elżbieta Ciara, Janusz B Książyk, Ewa Pronicka
Leigh syndrome (LS), subacute necrotizing encephalomyelopathy is caused by various genetic defects, including m.9185T>C MTATP6 variant. Mechanism of LS development remains unknown. We report on the acid-base status of three patients with m.9185T>C related LS. At the onset, it showed respiratory alkalosis, reflecting excessive respiration effort (hyperventilation with low pCO2). In patient 1, the deterioration occurred in temporal relation to passive oxygen therapy. To the contrary, on the recovery, she demonstrated a relatively low respiratory drive, suggesting that a "hypoventilation" might be beneficial for m...
November 7, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29108613/obesity-hypoventilation-syndrome-choosing-the-appropriate-treatment-of-a-heterogeneous-disorder
#5
REVIEW
Amanda J Piper, Ahmed S BaHammam, Shahrokh Javaheri
The obesity hypoventilation syndrome (OHS) is associated with significant morbidity and increased mortality compared with simple obesity and eucapnic obstructive sleep apnea. Accurate diagnosis and commencement of early and appropriate management is fundamental in reducing the significant personal and societal burdens this disorder poses. Sleep disordered breathing is a major contributor to the developmental of sleep and awake hypercapnia, which characterizes OHS, and is effectively addressed through the use of positive airway pressure (PAP) therapy...
December 2017: Sleep Medicine Clinics
https://www.readbyqxmd.com/read/29108606/positive-airway-pressure-device-technology-past-and-present-what-s-in-the-black-box
#6
REVIEW
Lee K Brown, Shahrokh Javaheri
Since the introduction of continuous positive airway pressure (PAP) for the treatment of obstructive sleep apnea (OSA) in 1981, PAP technology has diversified exponentially. Compact and quiet fixed continuous PAP flow generators, autotitrating PAP devices, and bilevel PAP devices that can treat multiple sleep-disordered breathing phenotypes including OSA, central sleep apnea (CSA), combinations of OSA and CSA, and hypoventilation are available. Adaptive servo-ventilators can suppress Hunter-Cheyne-Stokes breathing and CSA and treat coexisting obstructive events...
December 2017: Sleep Medicine Clinics
https://www.readbyqxmd.com/read/29105265/sleep-disordered-breathing-management-update
#7
Anna Mohammadieh, Kate Sutherland, Peter A Cistulli
The term sleep disordered breathing encompasses a spectrum of abnormalities, including snoring, obstructive sleep apnoea (OSA), central sleep apnoea (CSA), respiratory-related arousals and hypoventilation. This review focuses on both OSA and CSA. It provides a clinical update of recent advances in the diagnosis, management and prognosis of these two conditions. An increasing array of treatment modalities, particularly for OSA, broadens the opportunity for personalised therapy tailored to the individual patient...
November 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29103673/prognosis-of-obesity-hypoventilation-syndrome-with-and-without-concomitant-obstructive-sleep-apnea-syndrome
#8
Ana Rodriguez Alvarez, Lidia Méndez Marote, Olalla Castro Añón, Rafael Golpe Gómez, Luis Alejandro Pérez de Llano
No abstract text is available yet for this article.
November 2, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29098737/structural-and-functional-differences-in-phox2b-frameshift-mutations-underlie-isolated-or-syndromic-congenital-central-hypoventilation-syndrome
#9
Simona Di Lascio, Roberta Benfante, Eleonora Di Zanni, Silvia Cardani, Annalisa Adamo, Diego Fornasari, Isabella Ceccherini, Tiziana Bachetti
Heterozygous mutations in the PHOX2B gene are causative of Congenital Central Hypoventilation Syndrome (CCHS), a neurocristopathy characterised by defective autonomic control of breathing due to the impaired differentiation of neural crest cells (NCCs). Among PHOX2B mutations, polyalanine (polyAla) expansions are almost exclusively associated with isolated CCHS, whereas frameshift variants, although less frequent, are often more severe than polyAla expansions and identified in syndromic CCHS. This paper provides a complete review of all the frameshift mutations identified in cases of isolated and syndromic CCHS reported in the literature as well as those identified by us and not yet published...
November 2, 2017: Human Mutation
https://www.readbyqxmd.com/read/29083022/predictors-of-noninvasive-ventilation-failure-in-critically-ill-obese-patients-a-brief-narrative-review
#10
Antonello Nicolini, Malcom Lemyze, Antonio Esquinas, Cornelius Barlascini, Maurizio A Cavalleri
 Non-invasive ventilation ( NIV ) has been used successfully for the management of acute respiratory failure (ARF) more often in the last two decades than previously. Unfortunately, NIV can have failure rates ranging from 5% to 50% and patient selection is the key to success. There are particular groups of patients that are more likely to benefit from NIV. For patients with hypoventilation syndrome (OHS) this treatment can be beneficial. This review seeks to evaluate the effectiveness of NIV in acute ARF and determine predictors of NIV failure in morbidly obese patients...
2017: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/29074813/nero-a-pilot-study-but-important-step-towards-comprehensive-management-of-obesity-hypoventilation-syndrome
#11
EDITORIAL
Jean-Christian Borel, Anne Laure Borel, Amanda J Piper
No abstract text is available yet for this article.
October 26, 2017: Thorax
https://www.readbyqxmd.com/read/29065952/barriers-to-cpap-use-in-india-an-exploratory-study
#12
Abhishek Goyal, Namrata Agarwal, Abhijit Pakhare
STUDY OBJECTIVES: To investigate adherence to continuous positive airway pressure (CPAP) therapy and identify barriers to CPAP use among patients with obstructive sleep apnea (OSA) in India. METHODS: A self-devised semistructured questionnaire (which collected patients' demographic information, socioeconomic position, and information about disease status, symptoms, and complications) was administered to consecutive patients with moderate to severe OSA from June 2015 to August 2016...
October 18, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29054915/prevalence-of-sleep-apnoea-and-capnographic-detection-of-nocturnal-hypoventilation-in-amyotrophic-lateral-sclerosis
#13
Matthias Boentert, Christian Glatz, Cornelia Helmle, Angelika Okegwo, Peter Young
OBJECTIVE: This retrospective study aimed to investigate whether overnight oxymetry and early morning blood gas analysis predict nocturnal hypoventilation (NH) as reflected by night-time hypercapnia in patients with amyotrophic lateral sclerosis (ALS). In addition, prevalence and clinical determinants of sleep apnoea in ALS were evaluated. METHODS: In 250 patients with non-ventilated ALS, transcutaneous capnometry was performed along with polysomnography or polygraphy and early morning blood gases...
October 20, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29050165/-ovarian-tumor-associated-with-anti-n-methyl-d-aspartate-receptor-encephalitis-a-report-of-15-cases
#14
X M Li, H Y Jiang, Y F Wang, W Qiu, Y Wang, H T Wu
Objective: To summarize the clinical features of patients with ovarian tumor and anti-N-methyl-D-aspartate receptor(NMDAR) encephalitis, and to explore the influence of operation patterns on the prognosis. Methods: The clinical information of patients with ovarian tumor and anti-NMDAR encephalitis in The 3rd Affiliated Hospital of Sun Yat-Sen University and The Zhujiang Hospital of Southern Medical University were collected and analyzed. Results: There were 15 patients were enrolled in this study, with the average age of 24...
October 10, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29032393/acute-effects-of-repeated-cycling-sprints-in-hypoxia-induced-by-voluntary-hypoventilation
#15
Xavier Woorons, Patrick Mucci, Julien Aucouturier, Agathe Anthierens, Grégoire P Millet
PURPOSE: This study aimed to investigate the acute responses to repeated-sprint exercise (RSE) in hypoxia induced by voluntary hypoventilation at low lung volume (VHL). METHODS: Nine well-trained subjects performed two sets of eight 6-s sprints on a cycle ergometer followed by 24 s of inactive recovery. RSE was randomly carried out either with normal breathing (RSN) or with VHL (RSH-VHL). Peak (PPO) and mean power output (MPO) of each sprint were measured. Arterial oxygen saturation, heart rate (HR), gas exchange and muscle concentrations of oxy-([O2Hb]) and deoxyhaemoglobin/myoglobin ([HHb]) were continuously recorded throughout exercise...
December 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29017960/upper-respiratory-tract-nociceptor-stimulation-and-stress-response-following-acute-and-repeated-cyfluthrin-inhalation-in-normal-and-pregnant-rats-physiological-rat-specific-adaptions-can-easily-be-misunderstood-as-adversities
#16
Juergen Pauluhn
This paper reviews the results from past regulatory and mechanistic inhalation studies in rats with the type II pyrethroid Cyfluthrin. Apart from many chemical irritants, Cyfluthrin was shown to be a neuroexcitatory agent without any inherent tissue-destructive or irritant property. Thus, any Cyfluthrin-induced neuroexcitatory afferent sensory stimulus from peripheral nociceptors in the upper respiratory tract is likely to be perceived as a transient stimulus triggering annoyance and/or avoidance by both rats and humans...
October 7, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29017230/-guidelines-in-practice-the-new-s3-guideline-sleeping-disorders-sleep-related-abnormal-breathing
#17
Martin Gerlach, Bernd Sanner
Sleep related breathing disorders include central sleep apnea (CSA), obstructive sleep apnea (OSA), sleep-related hypoventilation, and sleep-related hypoxia. These disorders are frequent and growing in clinical relevance. The related chapter of the S3 guideline "Non-restorative sleep/Sleep disorders", published by the German Sleep Society (DGSM), has recently been updated in November 2016. Epidemiology, diagnostics, therapeutic procedures, and classification of sleep related disorders have been revised. Concerning epidemiology, a considerably higher mortality rate among pregnant women with OSA has been emphasized...
October 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28992836/carbamazepine-improves-apneic-episodes-in-congenital-central-hypoventilation-syndrome-cchs-with-a-novel-phox2b-exon-1-missense-mutation
#18
Schaida Schirwani, Karen Pysden, Philip Chetcuti, Moira Blyth
No abstract text is available yet for this article.
October 4, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28983937/factors-associated-with-change-in-health-related-quality-of-life-among-individuals-treated-with-long-term-mechanical-ventilation-a-six-year-follow-up-study
#19
Heidi Markussen, Sverre Lehmann, Roy M Nilsen, Gerd K Natvig
AIMS: To examine changes and explanatory variables for changes in health-related quality of life in patients treated with long-term mechanical ventilation over a six-year period. BACKGROUND: Long-term mechanical ventilation is a treatment for individuals with chronic hypercapnic respiratory failure, primarily caused by neuromuscular diseases, obesity hypoventilation syndrome, chronic obstructive pulmonary and restrictive thoracic diseases. Studies on long-term outcome on health-related quality of life and factors influencing it are lacking...
October 6, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28974061/supraglottic-jet-oxygenation-and-ventilation-enhances-oxygenation-during-upper-gastrointestinal-endoscopy-in-patients-sedated-with-propofol-a-randomized-multicentre-clinical-trial
#20
Y Qin, L Z Li, X Q Zhang, Y Wei, Y L Wang, H F Wei, X R Wang, W F Yu, D S Su
Background: Hypoventilation is the main reason for hypoxia during upper gastrointestinal endoscopy procedures with sedation. The key to preventing hypoxia is to maintain normal ventilation during the procedure. We introduced supraglottic jet oxygenation and ventilation (SJOV) through a new Wei nasal jet tube (WNJ) to reduce the incidence of hypoxia in patients sedated with propofol during upper gastrointestinal endoscopy procedures. Methods: In a multicentre, prospective randomized single-blinded study, 1781 outpatients undergoing routine upper gastrointestinal endoscopy who were sedated with propofol by an anaesthetist were randomized into the following three groups: the supplementary oxygen via nasal cannula group [nasal cannula oxygen: O 2 (2 litres min -1 ) was administered via a nasal cannula]; the supplementary oxygen via WNJ group [WNJ oxygen: O 2 (2 litres min -1 ) was administered through a WNJ]; and the SJOV via WNJ group (WNJ SJOV: SJOV was administered via WNJ) at three centres from March 2015 to July 2016...
July 1, 2017: British Journal of Anaesthesia
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