Benjamin Pankratz, Bernd Feige, Kimon Runge, Karl Bechter, Miriam A Schiele, Katharina Domschke, Harald Prüss, Ludger Tebartz van Elst, Kathrin Nickel, Dominique Endres
BACKGROUND: Obsessive-compulsive disorder (OCD) and Tourette syndrome (TS) are related mental disorders that share genetic, neurobiological, and phenomenological features. Pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS) is a neuropsychiatric autoimmune disorder with symptoms of OCD and/or TS associated with streptococcal infections. Therefore, PANDAS represents a strong link between OCD, TS, and autoimmunity. Notably, cerebrospinal fluid (CSF) analyses can provide insight into the central nervous processes in OCD, TS, and PANDAS...
January 2024: Brain, Behavior, and Immunity