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JOURNAL ARTICLE
Orri Smárason, Robert R Selles, Davíð R M A Højgaard, John R Best, Karin Melin, Tord Ivarsson, Per Hove Thomsen, Bernhard Weidle, Nicole Michelle McBride, Eric A Storch, Daniel Geller, Sabine Wilhelm, Lara J Farrell, Allison M Waters, Sharna Mathieu, Noam Soreni, S Evelyn Stewart, Gudmundur Skarphedinsson
Given diverse symptom expression and high rates of comorbid conditions, the present study explored underlying commonalities among OCD-affected children and adolescents to better conceptualize disorder presentation and associated features. Data from 830 OCD-affected participants presenting to OCD specialty centers was aggregated. Dependent mixture modeling was used to examine latent clusters based on their age- and gender adjusted symptom severity (as measured by the Children's Yale-Brown Obsessive-Compulsive Scale; CY-BOCS), symptom type (as measured by factor scores calculated from the CY-BOCS symptom checklist), and comorbid diagnoses (as assessed via diagnostic interviews)...
April 18, 2024: European Child & Adolescent Psychiatry
#2
JOURNAL ARTICLE
Jared N Smith, Natalie Dorfman, Meghan Hurley, Ilona Cenolli, Kristin Kostick-Quenet, Eric A Storch, Gabriel Lázaro-Muñoz, Jennifer Blumenthal-Barby
The ongoing debate within neuroethics concerning the degree to which neuromodulation such as deep brain stimulation (DBS) changes the personality, identity, and agency (PIA) of patients has paid relatively little attention to the perspectives of prospective patients. Even less attention has been given to pediatric populations. To understand patients' views about identity changes due to DBS in obsessive-compulsive disorder (OCD), the authors conducted and analyzed semistructured interviews with adolescent patients with OCD and their parents/caregivers...
April 11, 2024: Cambridge Quarterly of Healthcare Ethics: CQ
#3
Marie-Louis Wronski, Ralf Kuja-Halkola, Elin Hedlund, Miriam I Martini, Paul Lichtenstein, Sebastian Lundström, Henrik Larsson, Mark J Taylor, Nadia Micali, Cynthia M Bulik, Lisa Dinkler
BACKGROUND: Avoidant restrictive food intake disorder (ARFID) is a feeding and eating disorder, characterized by limited variety and/or quantity of food intake impacting physical health and psychosocial functioning. Children with ARFID often present with a range of psychiatric and somatic symptoms, and therefore consult various pediatric subspecialties; large-scale studies mapping comorbidities are however lacking. To characterize health care needs of people with ARFID, we systematically investigated ARFID-related mental and somatic conditions in 616 children with ARFID and >30,000 children without ARFID...
March 15, 2024: medRxiv
#4
JOURNAL ARTICLE
Asmaa A El Sehmawy, Shaimaa Younes Abd Elaziz, Asmaa Abdelghany Elsheikh, Fatma A Elsawy, Amal Abd Elsalam Amin, Ahmed Mostafa Omran, Amal Younan Abd El Malek
PURPOSE: The current study aimed to determine the prevalence of specific psychiatric disorders, identify predictors associated with these disorders, and assess the quality of life (QoL) among children with congenital heart disease. METHODS: This comparative cross-sectional study was conducted in the National Heart Institute outpatient clinics. It included 204 children with structural congenital heart defects (CHD). In addition to assessing QoL with the Pediatric Quality of Life Inventory scale, the Mini-International Neuropsychiatric Interview for Children and Adolescents was utilized to identify psychiatric disorders in the children studied...
March 29, 2024: Journal of Pediatric Rehabilitation Medicine
#5
JOURNAL ARTICLE
Gail A Bernstein, Maroof H Khan, Rebecca L Freese, Cindy Manko, Melissa Silverman, Sana Ahmed, Bahare Farhadian, Meiqian Ma, Margo Thienemann, Tanya K Murphy, Jennifer Frankovich
Objectives: Pediatric acute-onset neuropsychiatric syndrome (PANS) is characterized by sudden onset of obsessive-compulsive disorder and/or eating restriction with associated neuropsychiatric symptoms from at least two of seven categories. The PANS 31-Item Symptom Rating Scale (PANS Rating Scale) was developed to identify and measure the severity of PANS symptoms. The objective of this study was to define the psychometric properties of the PANS Rating Scale. Methods: Children with PANS ( N = 135) and their parents participated...
March 27, 2024: Journal of Child and Adolescent Psychopharmacology
#6
JOURNAL ARTICLE
Şeyma Erdem Torun, Sinem Akgül, Melis Pehlivantürk Kızılkan, Kevser Nalbant, Nuray Kanbur, Devrim Akdemir, Burcu Ersöz Alan, Zeynep Tüzün, Orhan Derman
BACKGROUND: At the onset of the pandemic, we conducted a study on adolescents with eating disorders (EDs) and found no deterioration in ED symptoms. The objective of this subsequent study was to conduct a follow-up evaluation of the same cohort and investigate the consequences of the prolonged pandemic. METHODS: This longitudinal study was conducted one year after the first study between May 2021 and June 2021 with 37 adolescents aged 12-18 years (pre-existing EDs)...
2024: Turkish Journal of Pediatrics
#7
Gregory Hanna, Yanni Liu, Lauren Rentschler, Barbara Hanna, Paul Arnold, William Gehring
The error-related negativity (ERN) and error positivity (Pe) are components of the event-related potential following an error that are potential mechanistic biomarkers of obsessive-compulsive disorder (OCD). The study examined the ERN, Pe, flanker task accuracy, and clinical measures in 105 OCD cases and 105 matched healthy controls (HC), ages 8 to 18 years, with 21 cases having a tic disorder history. Higher flanker task accuracy in all participants was associated with an increased ERN amplitude and increased difference between Pe and correct positivity amplitudes (ΔPe)...
February 13, 2024: Research Square
#8
JOURNAL ARTICLE
Giulia Conte, Carola Costanza, Maria Novelli, Veronica Scarselli, Elena Arigliani, Francesca Valente, Valentina Baglioni, Arianna Terrinoni, Flavia Chiarotti, Francesco Cardona
BACKGROUND: Cognitive functions represent foundational factors for mental health and quality of life (QoL). In Tourette syndrome (TS), psychiatric comorbidities are common and have been inconsistently reported to affect the cognition and QoL of patients, while the role of tic disorder duration has not been yet explored. METHODS: To examine how comorbidities and TS duration may influence cognition and QoL, N = 80 children with TS (6-16 years) were evaluated using the Wechsler Intelligence Scale for Children (WISC-IV)...
February 9, 2024: Children
#9
JOURNAL ARTICLE
Davide Fausto Borrelli, Laura Dell'Uva, Andrea Provettini, Luca Gambolò, Anna Di Donna, Rebecca Ottoni, Carlo Marchesi, Matteo Tonna
People with obsessive compulsive disorder (OCD) are at increased risk of developing psychotic disorders; yet little is known about specific clinical features which might hint at this vulnerability. The present study was aimed at elucidating the pathophysiological mechanism linking OCD to psychosis through the investigation of childhood trauma experiences in adolescents and adults with OCD. One hundred outpatients, aged between 12 and 65 years old, were administered the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and its Child version (CY-BOCS), as well as the Childhood Trauma Questionnaire (CTQ); Cognitive-Perceptual basic symptoms (COPER) and high-risk criterion Cognitive Disturbances (COGDIS) were assessed in the study sample...
January 24, 2024: Brain Sciences
#10
JOURNAL ARTICLE
Meryl Rueppel, Hannah C Becker, Ann Iturra-Mena, Emily L Bilek, Christopher S Monk, K Luan Phan, Kate D Fitzgerald
Subclinical symptoms of obsessive-compulsive disorder (i.e., obsessive compulsive symptoms, or "OCS") cause functional impairment, including for youth without full-syndrome OCD. Further, despite high rates of OCS in youth with anxiety disorders, knowledge of OCS in the context of specific anxiety disorders is limited. The present study seeks to: (1) compare OCS in pediatric patients with anxiety disorders and healthy youth, (2) determine which categorical anxiety disorder(s) associate most with OCS, and (3) determine relationships between OCS with anxiety severity and impairment...
February 14, 2024: Child Psychiatry and Human Development
#11
JOURNAL ARTICLE
Bo-Gyeom Kim, Gakyung Kim, Yoshinari Abe, Pino Alonso, Stephanie Ameis, Alan Anticevic, Paul D Arnold, Srinivas Balachander, Nerisa Banaj, Nuria Bargalló, Marcelo C Batistuzzo, Francesco Benedetti, Sara Bertolín, Jan Carl Beucke, Irene Bollettini, Silvia Brem, Brian P Brennan, Jan K Buitelaar, Rosa Calvo, Miguel Castelo-Branco, Yuqi Cheng, Ritu Bhusal Chhatkuli, Valentina Ciullo, Ana Coelho, Beatriz Couto, Sara Dallaspezia, Benjamin A Ely, Sónia Ferreira, Martine Fontaine, Jean-Paul Fouche, Rachael Grazioplene, Patricia Gruner, Kristen Hagen, Bjarne Hansen, Gregory L Hanna, Yoshiyuki Hirano, Marcelo Q Höxter, Morgan Hough, Hao Hu, Chaim Huyser, Toshikazu Ikuta, Neda Jahanshad, Anthony James, Fern Jaspers-Fayer, Selina Kasprzak, Norbert Kathmann, Christian Kaufmann, Minah Kim, Kathrin Koch, Gerd Kvale, Jun Soo Kwon, Luisa Lazaro, Junhee Lee, Christine Lochner, Jin Lu, Daniela Rodriguez Manrique, Ignacio Martínez-Zalacaín, Yoshitada Masuda, Koji Matsumoto, Maria Paula Maziero, Jose M Menchón, Luciano Minuzzi, Pedro Silva Moreira, Pedro Morgado, Janardhanan C Narayanaswamy, Jin Narumoto, Ana E Ortiz, Junko Ota, Jose C Pariente, Chris Perriello, Maria Picó-Pérez, Christopher Pittenger, Sara Poletti, Eva Real, Y C Janardhan Reddy, Daan van Rooij, Yuki Sakai, João Ricardo Sato, Cinto Segalas, Roseli G Shavitt, Zonglin Shen, Eiji Shimizu, Venkataram Shivakumar, Carles Soriano-Mas, Nuno Sousa, Mafalda Machado Sousa, Gianfranco Spalletta, Emily R Stern, S Evelyn Stewart, Philip R Szeszko, Rajat Thomas, Sophia I Thomopoulos, Daniela Vecchio, Ganesan Venkatasubramanian, Chris Vriend, Susanne Walitza, Zhen Wang, Anri Watanabe, Lidewij Wolters, Jian Xu, Kei Yamada, Je-Yeon Yun, Mojtaba Zarei, Qing Zhao, Xi Zhu, Paul M Thompson, Willem B Bruin, Guido A van Wingen, Federica Piras, Fabrizio Piras, Dan J Stein, Odile A van den Heuvel, Helen Blair Simpson, Rachel Marsh, Jiook Cha
White matter pathways, typically studied with diffusion tensor imaging (DTI), have been implicated in the neurobiology of obsessive-compulsive disorder (OCD). However, due to limited sample sizes and the predominance of single-site studies, the generalizability of OCD classification based on diffusion white matter estimates remains unclear. Here, we tested classification accuracy using the largest OCD DTI dataset to date, involving 1336 adult participants (690 OCD patients and 646 healthy controls) and 317 pediatric participants (175 OCD patients and 142 healthy controls) from 18 international sites within the ENIGMA OCD Working Group...
February 7, 2024: Molecular Psychiatry
#12
JOURNAL ARTICLE
Jessica Szu-Chi Cheng, Elissa Khalil, Masoud Salehi, Lauren Mulcahy, Isabella Yiru Xie, Hasti Hadizadeh, Marco A Grados
INTRODUCTION: Pediatric obsessive-compulsive disorder (OCD), attention-deficit hyperactivity disorder (ADHD), and Tourette syndrome (TS) are often concurrent. This study explores the temperament profile of complex OCD phenotypes. METHODS: A clinical registry recorded demographic data, psychiatric diagnoses, and temperament traits, including novelty seeking (exploratory behaviors), harm avoidance (fear of uncertainty), reward dependence (sentimentality), and persistence (perseverance)...
January 29, 2024: Psychopathology
#13
JOURNAL ARTICLE
Saverio La Bella, Marina Attanasi, Armando Di Ludovico, Giovanna Scorrano, Francesca Mainieri, Francesca Ciarelli, Federico Lauriola, Luisa Silvestrini, Virginia Girlando, Francesco Chiarelli, Luciana Breda
BACKGROUND: Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) syndrome is a rare pediatric disorder consisting of a sudden onset of obsessive-compulsive disorder (OCD) and/or tics after a group A Streptococcus (GAS) infection. METHODS: In the period between 2013 and 2023, 61 children presented to our Pediatric Rheumatology unit with a suspicion of PANDAS syndrome. Among these, a retrospective analysis was conducted, and 19 fulfilled the current classification criteria and were included in this study...
December 19, 2023: Microorganisms
#14
Joan Jory, Kenneth Handelman
BACKGROUND: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal (strep) infections (PANDAS) are a recognized medical entity among children. But evidence for strep-mediated sudden-onset obsessive-compulsive disorder (OCD) in young adults is very limited. Delayed strep assessment and treatment may negatively impact clinical outcomes. METHODS: We describe a young adult with acute sudden-onset OCD (age 24), treated unsuccessfully with medication and therapy for 3 years...
January 16, 2024: Healthcare (Basel, Switzerland)
#15
JOURNAL ARTICLE
Emily Strouphauer, Carlos Valenzuela-Flores, Abu Minhajuddin, Holli Slater, David B Riddle, Caitlin M Pinciotti, Andrew G Guzick, John M Hettema, Silvina Tonarelli, Cesar A Soutullo, Joshua S Elmore, Kimberly Gushanas, Sarah Wakefield, Wayne K Goodman, Madhukar H Trivedi, Eric A Storch, Matti Cervin
BACKGROUND: Major depressive disorder (MDD) is common in youth and among the most frequent comorbid disorders in pediatric obsessive-compulsive disorder (OCD), but it is unclear whether the presence of OCD affects the symptom presentation of MDD in youth. METHODS: A sample of youth with OCD and MDD (n = 124) and a sample of youth with MDD but no OCD (n = 673) completed the Patient Health Questionnaire for Adolescents (PHQ-A). The overall and symptom-level presentation of MDD were examined using group comparisons and network analysis...
January 8, 2024: Journal of Affective Disorders
#16
JOURNAL ARTICLE
Tevfik Demir, Ilgin Yildirim Simsir, Ozlem Kuman Tuncel, Burcu Ozbaran, Ilker Yildirim, Sebnem Pirildar, Samim Ozen, Baris Akinci
BACKGROUND: Lipodystrophy is a rare disease characterized by loss of adipose tissue. Natural history studies have demonstrated significant burden of disease; however, there is limited data on the impact of lipodystrophy on quality of life (QoL) and psychoemotional well-being. The QuaLip study is a prospective observational real-world study that aims to determine the impact of lipodystrophy on QoL and psychoemotional well-being and explore subjective burden of the disease. Sixty-seven adult patients and eight pediatric patients with lipodystrophy were included...
January 5, 2024: Orphanet Journal of Rare Diseases
#17
REVIEW
Matti Cervin, Joseph F McGuire, Johann M D'Souza, Alessandro S De Nadai, Kristina Aspvall, Wayne K Goodman, Per Andrén, Sophie C Schneider, Daniel A Geller, David Mataix-Cols, Eric A Storch
BACKGROUND: Cognitive-behavioral therapy (CBT) and serotonin reuptake inhibitors (SRIs) are recommended treatments for pediatric obsessive-compulsive disorder (OCD), but their relative efficacy and acceptability have not been comprehensively examined. Further, it remains unclear whether the efficacy of in-person CBT is conserved when delivered in other formats, such as over telephone/webcam or as Internet-delivered CBT (ICBT). METHODS: PubMed, PsycINFO, trial registries, and previous systematic reviews were searched for randomized controlled trials (RCTs) comparing CBT (in-person, webcam/telephone-delivered, or ICBT) or SRIs with control conditions or each other...
January 3, 2024: Journal of Child Psychology and Psychiatry, and Allied Disciplines
#18
JOURNAL ARTICLE
Daniel A Geller, Mia Grossman
OBJECTIVE: To use a family genetic study to evaluate familial risk of obsessive compulsive disorder (OCD) and common comorbid illnesses in first-degree relatives of pediatric-onset probands with primary OCD. METHOD: One hundred and thirty youth with OCD and their 133 siblings and 241 parents and 49 pediatric controls were directly evaluated along multiple domains including psychopathology using structured diagnostic interviews and clinical corroboration. RESULTS: Rates of anxiety, mood, disruptive behavior, and tic disorders were markedly elevated in the probands while rates in siblings were elevated at rates between the probands and controls...
December 28, 2023: Journal of Attention Disorders
#19
Abdullah Nasser Alqifari, Benjamin Maxwell
Pediatric acute-onset neuropsychiatric syndrome (PANS) is a clinical condition with abrupt onset of obsessive-compulsive symptoms and/or severe eating restrictions and at least two concomitant cognitive, behavioral, or neurological symptoms. Pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS) is a subtype of PANS with a controversial diagnosis. A case of a 12-year-old girl with severe eating restriction, obsessive-compulsive symptoms, anxiety, and neurological symptoms who initially was diagnosed with obsessive-compulsive disorder is presented...
2023: Case Reports in Psychiatry
#20
REVIEW
Jordan T Stiede, Samuel D Spencer, Ogechi Onyeka, Katie H Mangen, Molly J Church, Wayne K Goodman, Eric A Storch
Obsessive-compulsive disorder (OCD) in children and adolescents is a neurobehavioral condition that can lead to functional impairment in multiple domains and decreased quality of life. We review the clinical presentation, diagnostic considerations, and common comorbidities of pediatric OCD. An overview of the biological and psychological models of OCD is provided along with a discussion of developmental considerations in youth. We also describe evidence-based treatments for OCD in childhood and adolescence, including cognitive behavioral therapy (CBT) with exposure and response prevention (ERP) and pharmacotherapy...
December 15, 2023: Annual Review of Clinical Psychology
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