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Pediatric obsessive compulsive disorder

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https://www.readbyqxmd.com/read/28756555/children-s-and-parents-ability-to-tolerate-child-distress-impact-on-cognitive-behavioral-therapy-for-pediatric-obsessive-compulsive-disorder
#1
Robert R Selles, Martin Franklin, Jeffrey Sapyta, Scott N Compton, Doug Tommet, Richard N Jones, Abbe Garcia, Jennifer Freeman
The present study explored the concept of tolerance for child distress in 46 children (ages 5-8), along with their mothers and fathers, who received family-based CBT for OCD. The study sought to describe baseline tolerance, changes in tolerance with treatment, and the predictive impact of tolerance on symptom improvement. Tolerance was rated by clinicians on a single item and the CY-BOCS was used to measure OCD severity. Descriptive results suggested that all participants had some difficulty tolerating the child's distress at baseline while paired t tests indicated large improvements were made over treatment (d = 1...
July 29, 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/28714753/pediatric-acute-onset-neuropsychiatric-syndrome-response-to-oral-corticosteroid-bursts-an-observational-study-of-patients-in-an-academic-community-based-pans-clinic
#2
Kayla Brown, Cristan Farmer, Bahare Farhadian, Joseph Hernandez, Margo Thienemann, Jennifer Frankovich
BACKGROUND: Sudden-onset severe obsessive-compulsive symptoms and/or severely restrictive food intake with at least two coinciding, similarly debilitating neuropsychiatric symptoms define Pediatric Acute-onset Neuropsychiatric Syndrome (PANS). When associated with Group A Streptococcus, the syndrome is labeled Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections (PANDAS). An abnormal immune response to infection and subsequent neuroinflammation is postulated to play an etiologic role...
July 17, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28707590/combining-drug-and-psychological-treatments-for-obsessive-compulsive-disorder-what-is-the-evidence-when-and-for-whom
#3
Umberto Albert, Gabriele Di Salvo, Francesca Solia, Gianluca Rosso, Giuseppe Maina
BACKGROUND: serotonin reuptake inhibitors (SRIs) and cognitive-behavioral psychotherapy (CBT) are first-line treatments for obsessive-compulsive disorder (OCD). Since response is often inadequate, in recent years researchers investigated whether combining CBT and SRIs, either ab initio or sequentially, results in a greater reduction of obsessive-compulsive symptoms. OBJECTIVE: the aims of the present paper are to assess if combination treatment seems adding benefits as compared to either monotherapy alone and if sequential strategies may be effective in converting partial or non responders to a first-line treatment into responders...
July 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28696786/effect-of-early-and-prophylactic-nonsteroidal-anti-inflammatory-drugs-on-flare-duration-in-pediatric-acute-onset-neuropsychiatric-syndrome-an-observational-study-of-patients-followed-by-an-academic-community-based-pediatric-acute-onset-neuropsychiatric-syndrome
#4
Kayla D Brown, Cristan Farmer, G Mark Freeman, Ellen J Spartz, Bahare Farhadian, Margo Thienemann, Jennifer Frankovich
INTRODUCTION: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is characterized by the sudden onset of severe obsessive-compulsive symptoms and/or eating restriction along with at least two coinciding neuropsychiatric symptoms. When associated with group A Streptococcus, the syndrome is labeled Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections (PANDAS). An abnormal immune response to infection and subsequent neuroinflammation is postulated to play an etiologic role...
July 11, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28696783/course-of-neuropsychiatric-symptoms-after-introduction-and-removal-of-nonsteroidal-anti-inflammatory-drugs-a-pediatric-observational-study
#5
Ellen J Spartz, G Mark Freeman, Kayla Brown, Bahare Farhadian, Margo Thienemann, Jennifer Frankovich
OBJECTIVE: Accumulating evidence suggests that anti-inflammatory interventions can modulate neuropsychiatric symptoms. Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is characterized by an abrupt and dramatic onset of obsessive-compulsive (OC) symptoms and/or severely restrictive food intake and at least two coinciding, equally debilitating neuropsychiatric symptoms. When associated with group A Streptococcus, the syndrome is labeled Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections (PANDAS)...
July 11, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28691955/children-with-obsessive-compulsive-symptomology-in-the-general-population-different-subtypes
#6
Josjan Zijlmans, Reshmi Marhe, Jan van der Ende, Frank C Verhulst, Arne Popma, Henning Tiemeier, Odile A van den Heuvel
OBJECTIVE: Obsessive-compulsive disorder (OCD) is a moderately prevalent neurodevelopmental disorder, and many children suffer from subclinical obsessive-compulsive (OC) symptoms. The disorder is heterogeneous and has high comorbidity rates. In early disease stages of psychiatric disorders, symptoms are typically hard to attribute exclusively to specific disorders. The authors investigated whether profiles of neuropsychiatric symptoms can be distinguished within a large population-based study of school-aged children (7-10 years) scoring high on OC symptoms...
July 6, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28659986/efficacy-of-n-acetylcysteine-augmentation-on-obsessive-compulsive-disorder-a-multicenter-randomized-double-blind-placebo-controlled-clinical-trial
#7
Ahmad Ghanizadeh, Mohammad Reza Mohammadi, Shahla Bahraini, Zahra Keshavarzi, Ali Firoozabadi, Ali Alavi Shoshtari
Objective: Glutamate is considered a target for treating obsessive-compulsive disorder (OCD). The efficacy and safety of the nutritional supplement of N-Acetylcysteine (NAC) as an adjuvant to serotonin reuptake inhibitor (SSRI) for treating children and adolescents with OCD has never been examined. Method: This was a 10-week randomized double-blind placebo-controlled clinical trial with 34 OCD outpatients. The patients received citalopram plus NAC or placebo. Yale-Brown Obsessive-Compulsive Scale (YBOCS) and Pediatric Quality of Life Inventory (PedsQL™) were used...
April 2017: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/28645268/how-can-technology-enhance-cognitive-behavioral-therapy-the-case-of-pediatric-obsessive-compulsive-disorder
#8
Lidewij H Wolters, Vivian Op de Beek, Bernhard Weidle, Norbert Skokauskas
Many children with mental health disorders do not receive adequate treatment due to the uneven dissemination of resources, and other barriers to treatment. In the case of pediatric obsessive compulsive disorder treatment progress is also hindered by partial or non-response to treatment in addition to poor compliance. This debate paper focuses on new technologies as a potential vehicle to address the challenges faced by traditional treatment, with special reference to cognitive behavioral therapy for pediatric obsessive compulsive disorder...
June 23, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28631412/psychopathology-in-pediatric-bone-marrow-transplantation-survivors-and-their-mothers
#9
Aslı Sürer Adanir, Gülseren Taşkiran, O Alphan Küpesiz, Esin Özatalay
BACKGROUND: Bone Marrow Transplantation(BMT) is used to treat children with various hematologic, oncologic and metabolic diseases. While the treatment is lifesaving, it is also found to be related with anxiety, posttraumatic stress disorder, depression and psychosocial problems both in children and parents. METHODS: The aim of this study was to investigate psychopathology in pediatric BMT survivors and their mothers compared to the healthy controls. All children were interviewed using Kiddie Schedule for Affective Disorders and Schizophrenia for assessing the life-long psychopathology...
June 20, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28557252/a-case-study-integrating-cbt-with-narrative-therapy-externalizing-techniques-with-a-child-with-ocd-how-to-flush-away-the-silly-gremlin-a-single-case-experimental-design
#10
Rosemary Banting, Susannah Lloyd
PROBLEM: Evidence exists for the use of cognitive behavioral therapy (CBT) combined with externalizing techniques from narrative therapy for pediatric obsessive compulsive disorder (OCD); however, no research gives a detailed account of what the externalizing process looks like in session or how it is incorporated into conceptualization. Literature is appraised with respect to the referral, assessment, formulation, intervention and outcome. METHODS: The case describes a 10-year-old boy who was referred with severe OCD...
May 29, 2017: Journal of Child and Adolescent Psychiatric Nursing
https://www.readbyqxmd.com/read/28546883/how-much-do-we-know-about-adult-onset-primary-tics-prevalence-epidemiology-and-clinical-features
#11
REVIEW
Daphne Robakis
BACKGROUND: Tic disorders are generally considered to be of pediatric onset; however, reports of adult-onset tics exist in the literature. Tics can be categorized as either primary or secondary, with the latter being the larger group in adults. Primary or idiopathic tics that arise in adulthood make up a subset of tic disorders whose epidemiologic and clinical features have not been well delineated. METHODS: Articles to be included in this review were identified by searching PubMed, SCOPUS, and Web of Science using the terms adult- and late-onset tics, which resulted in 120 unique articles...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/28538981/association-of-streptococcal-throat-infection-with-mental-disorders-testing-key-aspects-of-the-pandas-hypothesis-in-a-nationwide-study
#12
Sonja Orlovska, Claus Høstrup Vestergaard, Bodil Hammer Bech, Merete Nordentoft, Mogens Vestergaard, Michael Eriksen Benros
Importance: Streptococcal infection has been linked with the development of obsessive-compulsive disorder (OCD) and tic disorders, a concept termed pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). However, previous studies of this association have been small, and the results have been conflicting. Objective: To investigate the risk of mental disorders, specifically OCD and tic disorders, after a streptococcal throat infection...
July 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28501261/obsessive-compulsive-symptoms-and-quality-of-life-in-mothers-of-children-with-atopic-dermatitis
#13
S Gunduz, E Usak, S Ozen, C Gorpelioglu
BACKGROUND AND OBJECTIVES: Atopic dermatitis is one of the most common skin disorders in children and it can negatively affect both children and their families. The purpose of this study was to investigate the effect of atopic dermatitis on quality of life related to maternal health and maternal obsessive compulsive symptoms. METHODS: A cross-sectional study was conducted in the pediatric and dermatology polyclinics. The SCORAD index was used for determining the severity of disease, and the Maudsley Obsessive Compulsive Inventory (MOCI) and SF-36 form were applied to the participants' mothers...
June 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28498087/an-expert-opinion-on-pandas-pans-highlights-and-controversies
#14
Francesca Chiarello, Silvia Spitoni, Eric Hollander, Marco Matucci Cerinic, Stefano Pallanti
OBJECTIVES: 'Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections' (PANDAS) identified a unique subgroup of patients with abrupt onset of obsessive compulsive disorder (OCD) symptoms clinically related to Streptococcus infection and accompanied by neuropsychological and motor symptoms. After almost 20 years, PANDAS has not been accepted as distinct disorder and new criteria for paediatric acute-onset neuropsychiatric syndrome (PANS) have been replaced it, highlighting the fact that several agents rather than only Streptococcus might be involved...
June 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28451624/tics-in-the-pediatric-population-pragmatic-management
#15
REVIEW
Christos Ganos, Davide Martino, Tamara Pringsheim
BACKGROUND: Primary tic disorders, notably Tourette syndrome, are very common movement disorders in childhood. However, the management of such patients still poses great therapeutic challenges to medical professionals. METHODS: Based on a synthesis of the available guidelines published in Europe, Canada, and the United States, coupled with more recent therapeutic developments, the authors provide a pragmatic guide to aid clinicians in deciding when and how to treat patients who have primary tic disorders...
March 2017: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/28431305/cognitive-behavioral-high-parental-involvement-treatments-for-pediatric-obsessive-compulsive-disorder-a-meta-analysis
#16
REVIEW
Marina Iniesta-Sepúlveda, Ana I Rosa-Alcázar, Julio Sánchez-Meca, José L Parada-Navas, Ángel Rosa-Alcázar
A meta-analysis on the efficacy of cognitive-behavior-family treatment (CBFT) on children and adolescents with obsessive-compulsive disorder (OCD) was accomplished. The purposes of the study were: (a) to estimate the effect magnitude of CBFT in ameliorating obsessive-compulsive symptoms and reducing family accommodation on pediatric OCD and (b) to identify potential moderator variables of the effect sizes. A literature search enabled us to identify 27 studies that fulfilled our selection criteria. The effect size index was the standardized pretest-postest mean change index...
June 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28422636/impact-of-pans-and-pandas-exacerbations-on-occupational-performance-a-mixed-methods-study
#17
Janice Trigilio Tona, Sutanuka Bhattacharjya, Denise Calaprice
OBJECTIVE: Pediatric acute-onset neuropsychiatric syndrome (PANS) includes pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and involves sudden-onset neuropsychiatric symptoms, including obsessions, compulsions, sensory difficulties, and dysgraphia after infection or other triggers. Our objective was to identify problems with areas of occupation, body functions, and performance skills during exacerbations. METHOD: In this online retrospective study, based on the Occupational Therapy Practice Framework: Domain and Process (2nd ed...
May 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28412602/secondary-outcomes-from-the-pediatric-obsessive-compulsive-disorder-treatment-study-ii
#18
Christine A Conelea, Robert R Selles, Kristen G Benito, Michael M Walther, Jason T Machan, Abbe M Garcia, Jeffrey Sapyta, Sarah Morris, Martin Franklin, Jennifer B Freeman
The Pediatric Obsessive-Compulsive Disorder Treatment Study II (POTS II) investigated the benefit of serotonin reuptake inhibitor (SRI) augmentation with cognitive behavioral therapy (CBT). Primary outcomes focused on OCD symptom change and indicated benefit associated with a full course of CBT. Given that the majority of youth with OCD suffer from significant comorbid symptoms and impaired quality of life, the current study examined POTS II data for effects on secondary outcomes. Participants were 124 youth ages 7-17 years with a primary diagnosis of OCD who were partial responders to an adequate SRI trial...
September 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28409563/glutamate-in-pediatric-obsessive-compulsive-disorder-and-response-to-cognitive-behavioral-therapy-randomized-clinical-trial
#19
Joseph O'Neill, John Piacentini, Susanna Chang, Ronald Ly, Tsz M Lai, Casey C Armstrong, Lindsey Bergman, Michelle Rozenman, Tara Peris, Allison Vreeland, Ross Mudgway, Jennifer G Levitt, Noriko Salamon, Stefan Posse, Gerhard S Hellemann, Jeffry R Alger, James T McCracken, Erika L Nurmi
Cognitive-behavioral therapy (CBT) is effective for pediatric obsessive-compulsive disorder (OCD), but non-response is common. Brain glutamate (Glu) signaling may contribute to OCD pathophysiology and moderate CBT outcomes. We assessed whether Glu measured with magnetic resonance spectroscopy (MRS) was associated with OCD and/or CBT response. Youths aged 8-17 with DSM-IV OCD and typically-developing controls underwent 3T proton echo-planar spectroscopic imaging (PEPSI) MRS scans of pregenual anterior cingulate cortex (pACC) and ventral posterior cingulate cortex (vPCC)-regions possibly affected by OCD-at baseline...
April 14, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28407363/de-novo-unbalanced-translocation-4p-duplication-8p-deletion-in-a-patient-with-autism-ocd-and-overgrowth-syndrome
#20
Angela Sagar, Dalila Pinto, Fedra Najjar, Stephen J Guter, Carol Macmillan, Edwin H Cook
Chromosomal abnormalities, such as unbalanced translocations and copy number variants (CNVs), are found in autism spectrum disorders (ASDs) [Sanders et al. (2011) Neuron 70: 863-885]. Many chromosomal abnormalities, including sub microscopic genomic deletions and duplications, are missed by G-banded karyotyping or Fragile X screening alone and are picked up by chromosomal microarrays [Shen et al. (2010) Pediatrics 125: e727-735]. Translocations involving chromosomes 4 and 8 are possibly the second most frequent translocation in humans and are often undetected in routine cytogenetics [Giglio et al...
June 2017: American Journal of Medical Genetics. Part A
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