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Pediatric obsessive compulsive disorder

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https://www.readbyqxmd.com/read/29179016/group-family-based-cognitive-behavioral-therapy-for-pediatric-obsessive-compulsive-disorder-global-outcomes-and-predictors-of-improvement
#1
Robert R Selles, Laura Belschner, Juliana Negreiros, Sarah Lin, David Schuberth, Katherine McKenney, Noel Gregorowski, Annie Simpson, Andrea Bliss, S Evelyn Stewart
This open, uncontrolled study examined the efficacy of a group family-based cognitive behavioral therapy (GF-CBT) protocol in treating pediatric obsessive-compulsive disorder (OCD) and explored predictors of symptom improvement. Eighty-five OCD-affected youth aged 8-18 years (M = 13.9 years, SD = 2.49; 46% male) and their parent(s) participated in a weekly, 12-session GF-CBT program. Data from multiple perspectives were gathered at the beginning and end of treatment, as well as at one-month follow-up. A broad range of assessment measures were utilized to capture clinically-relevant domains and a number of potential predictor variables were explored...
November 15, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29173737/targeted-family-intervention-for-complex-cases-of-pediatric-obsessive-compulsive-disorder-a%C3%A2-randomized-controlled-trial
#2
Tara S Peris, Michelle S Rozenman, Catherine A Sugar, James T McCracken, John Piacentini
OBJECTIVE: Although evidence-based treatments for pediatric obsessive-compulsive disorder (OCD) exist, many youth fail to respond, and interventions tailored to the needs of specific subsets of patients are lacking. This study examines the efficacy of a family intervention module designed for cases of OCD complicated by poor family functioning. METHOD: Participants were 62 youngsters aged 8 to 17 years (mean age = 12.71 years; 57% male; 65% white) with a primary diagnosis of OCD and at least 2 indicators of poor family functioning...
December 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29119912/the-glutamate-and-the-immune-systems-new-targets-for-the-pharmacological-treatment-of-ocd
#3
Donatella Marazziti, Umberto Albert, Federico Mucci, Armando Piccinni
BACKGROUND: In the last decades the pharmacological treatment of obsessive-compulsive disorder (OCD) has been significantly promoted by the effectiveness of selective serotonin (5-HT) reuptake inhibitors (SSRIs) and the subsequent development of the 5-HT hypothesis of OCD. However, since a large majority of patients (between 40% and 60 %) do not respond to SSRIs or strategies based on the modulation of the 5-HT system, it is now essential to search for other possible therapeutic targets...
November 8, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29119300/longitudinal-outcomes-of-children-with-pediatric-autoimmune-neuropsychiatric-disorder-associated-with-streptococcal-infections-pandas
#4
Jill Leon, Rebecca Hommer, Paul Grant, Cristan Farmer, Precilla D'Souza, Riley Kessler, Kyle Williams, James F Leckman, Susan Swedo
Little is known about the natural history of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS). This study prospectively followed 33 children with PANDAS for up to 4.8 years (mean 3.3 ± 0.7 years) after enrollment in a 24-week randomized, double-blind, placebo-controlled trial of intravenous immunoglobulin (IVIG) (N = 35). Fourteen of eighteen children randomized to placebo received open label IVIG 6 weeks after the blinded infusion, so follow-up results reported below largely reflect outcomes in a population of children who received at least one dose of IVIG...
November 8, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29112476/cross-sectional-evaluation-of-plasma-vitamin-d-levels-in-a-large-cohort-of-italian-patients-with-pediatric-autoimmune-neuropsychiatric-disorders-associated-with-streptococcal-infections
#5
Stefano Stagi, Gemma Lepri, Donato Rigante, Marco Matucci Cerinic, Fernanda Falcini
BACKGROUND: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are immune-mediated diseases characterized by obsessive-compulsive symptoms and/or tics triggered by group A Streptococcus infections. Despite the well-known action of 25-hydroxyvitamin D [25(OH)D] on different conditions driven by systemic inflammation, there are no data about the 25(OH)D status in patients with PANDAS. AIMS: To evaluate plasma 25(OH)D levels in a large cohort of children and adolescents with PANDAS and comparing the results with healthy controls...
November 7, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29102815/combining-genetic-and-epigenetic-parameters-of-the-serotonin-transporter-gene-in-obsessive-compulsive-disorder
#6
Edna Grünblatt, Zoya Marinova, Alexander Roth, Elena Gardini, Juliane Ball, Julia Geissler, Tomasz K Wojdacz, Marcel Romanos, Susanne Walitza
While genetic variants have been reported to be associated with obsessive-compulsive disorder (OCD), the small effect sizes suggest that epigenetic mechanisms such as DNA methylation may also be relevant. The serotonin transporter (SLC6A4) gene has been extensively investigated in relation to OCD, since serotonin reuptake inhibitors are the pharmacological treatment of choice for the disorder. The current study set three questions: Firstly, whether the high expressing loci of the SLC6A4 polymorphisms, 5-HTTLPR + rs25531, rs25532 and rs16965628 are associated with family-based (n = 164 trios) and case-control OCD (n = 186, 152, respectively)...
October 16, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29096776/one-year-outcome-for-responders-of-cognitive-behavioral-therapy-for-pediatric-obsessive-compulsive-disorder
#7
Davíð R M A Højgaard, Katja A Hybel, Tord Ivarsson, Gudmundur Skarphedinsson, Judith Becker Nissen, Bernhard Weidle, Karin Melin, Nor Christian Torp, Robert Valderhaug, Kitty Dahl, Erik Lykke Mortensen, Scott Compton, Sanne Jensen, Fabian Lenhard, Per Hove Thomsen
OBJECTIVE: This study describes 1-year treatment outcomes from a large sample of cognitive-behavioral therapy (CBT) responders, investigates age as a possible moderator of these treatment outcomes, and evaluates clinical relapse at the 1-year follow-up. METHOD: This study is the planned follow-up to the Nordic Long-term OCD [obsessive-compulsive disorder] Treatment Study (NordLOTS), which included 177 children and adolescents who were rated as treatment responders following CBT for OCD...
November 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29096772/enduring-effects-of-cognitive-behavioral-therapy-for-pediatric-obsessive-compulsive-disorder-the-nordic-experience
#8
EDITORIAL
Daniel A Geller
No abstract text is available yet for this article.
November 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29045303/riluzole-serum-concentration-in-pediatric-patients-treated-for-obsessive-compulsive-disorder
#9
Paul Grant, Cristan Farmer, Jane Song, Timothy Kish, Susan Swedo
PURPOSE/BACKGROUND: The goals of this study were to determine whether pediatric serum concentration of riluzole is similar to that observed in adults and to determine whether riluzole serum concentration is associated with adverse effects or efficacy in children and adolescents with treatment-refractory obsessive-compulsive disorder. METHODS/PROCEDURES: Data were drawn from previously published studies: 1 open-label trial and 1 randomized controlled trial with an open-label extension phase...
December 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29031217/quality-of-life-and-burden-in-caregivers-of-youth-with-obsessive-compulsive-disorder-presenting-for-intensive-treatment
#10
Monica S Wu, Rebecca Hamblin, Joshua Nadeau, Jessica Simmons, Ashley Smith, Meredith Wilson, Stephanie Eken, Brent Small, Vicky Phares, Eric A Storch
BACKGROUND: Pediatric obsessive-compulsive disorder (OCD) is associated with deleterious familial effects; caregivers are often enmeshed in the disorder and can experience considerable burden and decreased quality of life (QoL). Consequently, this study examined burden and QoL in caregivers of youth with OCD enrolled in an intensive outpatient or partial hospitalization program. METHOD: The relationships between caregiver QoL and burden and the following variables were investigated: OCD symptom severity, functioning (youth functional impairment, general family functioning), family (family accommodation, parental relationship satisfaction, positive aspects of caregiving), and comorbid psychopathology (caregiver anxiety and depressive symptoms, youth internalizing and externalizing behaviors)...
August 30, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28990850/the-relationship-between-toxoplasma-gondii-igg-antibodies-and-generalized-anxiety-disorder-and-obsessive-compulsive-disorder-in-children-and-adolescents-a-new-approach
#11
İsmail Akaltun, Soner Sertan Kara, Tayfun Kara
AIM: Toxoplasma gondii may play a role in the development of psychiatric diseases by affecting the brain. The purpose of this study was to examine the relation between serum toxoplasma IgG positivity and obsessive-compulsive disorder (OCD) and generalized anxiety disorder (GAD) in children and adolescents. METHOD: Sixty patients diagnosed with OCD and 60 patients with GAD presenting to the pediatric psychiatry clinic, together with 60 control group subjects with no psychiatric diagnosis, were included in the study...
October 9, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28956620/monotherapy-insufficient-in-severe-anxiety-predictors-and-moderators-in-the-child-adolescent-anxiety-multimodal-study
#12
Jerome H Taylor, Eli R Lebowitz, Ewgeni Jakubovski, Catherine G Coughlin, Wendy K Silverman, Michael H Bloch
This secondary analysis of the Child/Adolescent Anxiety Multimodal Study (CAMS) used baseline patient characteristics to identify prognostic subgroups of children based on likelihood of remission. We also investigated predictors and moderators of outcome. CAMS randomized 488 youths with generalized, social, and separation anxiety disorders to cognitive behavioral therapy (CBT), sertraline, both, or pill placebo. Outcomes were Week 12 child, parent, and independent evaluator (IE) ratings of child anxiety. We used receiver operating characteristics analysis and stepwise regression to identify predictors and moderators of outcome...
September 28, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28919236/biomarkers-for-diagnosis-of-pediatric-acute-neuropsychiatric-syndrome-pans-sensitivity-and-specificity-of-the-cunningham-panel
#13
Eva Hesselmark, Susanne Bejerot
OBJECTIVE: Pediatric Acute Neuropsychiatric Syndrome (PANS) and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are conditions marked by sudden onset of obsessive-compulsive disorder (OCD), tics, or avoidant/restrictive food intake in combination with multiple psychiatric symptoms. A diagnosis of PANS or PANDAS may be supported by the Cunningham Panel, a commercially available set of immunologic assays currently in clinical use. However, the relationship between Cunningham Panel results and patient symptoms remains unclear...
November 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28881220/executive-function-predicts-cognitive-behavioral-therapy-response-in-childhood-obsessive-compulsive-disorder
#14
Katja Anna Hybel, Erik Lykke Mortensen, Rikke Lambek, Davíð R M A Højgaard, Per Hove Thomsen
Cognitive-behavioral therapy (CBT) is considered first-line treatment for childhood obsessive-compulsive disorder (OCD). Despite CBT's efficacy, too many children and adolescents do not fully respond to treatment, making the identification of predictors of treatment response highly relevant. Executive functions (EF) have been suggested to constitute such predictors, but studies with pediatric samples are scarce. In the present study, we investigated latent level EF test performance and ratings of daily life EF behavior as predictors of CBT response in pediatric OCD...
August 26, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28756555/children-s-and-parents-ability-to-tolerate-child-distress-impact-on-cognitive-behavioral-therapy-for-pediatric-obsessive-compulsive-disorder
#15
Robert R Selles, Martin Franklin, Jeffrey Sapyta, Scott N Compton, Doug Tommet, Richard N Jones, Abbe Garcia, Jennifer Freeman
The present study explored the concept of tolerance for child distress in 46 children (ages 5-8), along with their mothers and fathers, who received family-based CBT for OCD. The study sought to describe baseline tolerance, changes in tolerance with treatment, and the predictive impact of tolerance on symptom improvement. Tolerance was rated by clinicians on a single item and the CY-BOCS was used to measure OCD severity. Descriptive results suggested that all participants had some difficulty tolerating the child's distress at baseline while paired t tests indicated large improvements were made over treatment (d = 1...
July 29, 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/28714753/pediatric-acute-onset-neuropsychiatric-syndrome-response-to-oral-corticosteroid-bursts-an-observational-study-of-patients-in-an-academic-community-based-pans-clinic
#16
Kayla Brown, Cristan Farmer, Bahare Farhadian, Joseph Hernandez, Margo Thienemann, Jennifer Frankovich
BACKGROUND: Sudden-onset severe obsessive-compulsive symptoms and/or severely restrictive food intake with at least two coinciding, similarly debilitating neuropsychiatric symptoms define Pediatric Acute-onset Neuropsychiatric Syndrome (PANS). When associated with Group A Streptococcus, the syndrome is labeled Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections (PANDAS). An abnormal immune response to infection and subsequent neuroinflammation is postulated to play an etiologic role...
September 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28707590/combining-drug-and-psychological-treatments-for-obsessive-compulsive-disorder-what-is-the-evidence-when-and-for-whom
#17
Umberto Albert, Gabriele Di Salvo, Francesca Solia, Gianluca Rosso, Giuseppe Maina
BACKGROUND: serotonin reuptake inhibitors (SRIs) and cognitive-behavioral psychotherapy (CBT) are first-line treatments for obsessive-compulsive disorder (OCD). Since response is often inadequate, in recent years researchers investigated whether combining CBT and SRIs, either ab initio or sequentially, results in a greater reduction of obsessive-compulsive symptoms. OBJECTIVE: the aims of the present paper are to assess if combination treatment seems adding benefits as compared to either monotherapy alone and if sequential strategies may be effective in converting partial or non responders to a first-line treatment into responders...
July 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28696786/effect-of-early-and-prophylactic-nonsteroidal-anti-inflammatory-drugs-on-flare-duration-in-pediatric-acute-onset-neuropsychiatric-syndrome-an-observational-study-of-patients-followed-by-an-academic-community-based-pediatric-acute-onset-neuropsychiatric-syndrome
#18
Kayla D Brown, Cristan Farmer, G Mark Freeman, Ellen J Spartz, Bahare Farhadian, Margo Thienemann, Jennifer Frankovich
INTRODUCTION: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is characterized by the sudden onset of severe obsessive-compulsive symptoms and/or eating restriction along with at least two coinciding neuropsychiatric symptoms. When associated with group A Streptococcus, the syndrome is labeled Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections (PANDAS). An abnormal immune response to infection and subsequent neuroinflammation is postulated to play an etiologic role...
September 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28696783/course-of-neuropsychiatric-symptoms-after-introduction-and-removal-of-nonsteroidal-anti-inflammatory-drugs-a-pediatric-observational-study
#19
Ellen J Spartz, G Mark Freeman, Kayla Brown, Bahare Farhadian, Margo Thienemann, Jennifer Frankovich
OBJECTIVE: Accumulating evidence suggests that anti-inflammatory interventions can modulate neuropsychiatric symptoms. Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is characterized by an abrupt and dramatic onset of obsessive-compulsive (OC) symptoms and/or severely restrictive food intake and at least two coinciding, equally debilitating neuropsychiatric symptoms. When associated with group A Streptococcus, the syndrome is labeled Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections (PANDAS)...
September 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28691955/children-with-obsessive-compulsive-symptomology-in-the-general-population-different-subtypes
#20
Josjan Zijlmans, Reshmi Marhe, Jan van der Ende, Frank C Verhulst, Arne Popma, Henning Tiemeier, Odile A van den Heuvel
OBJECTIVE: Obsessive-compulsive disorder (OCD) is a moderately prevalent neurodevelopmental disorder, and many children suffer from subclinical obsessive-compulsive (OC) symptoms. The disorder is heterogeneous and has high comorbidity rates. In early disease stages of psychiatric disorders, symptoms are typically hard to attribute exclusively to specific disorders. The authors investigated whether profiles of neuropsychiatric symptoms can be distinguished within a large population-based study of school-aged children (7-10 years) scoring high on OC symptoms...
September 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
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