Claire Tinel, Arnaud Devresse, Agathe Vermorel, Virginia Sauvaget, David Marx, Véronique Avettand-Fenoel, Lucile Amrouche, Marc Olivier Timsit, Renaud Snanoudj, Sophie Caillard, Bruno Moulin, Jérome Olagne, Marie Essig, Wilfried Gwinner, Maarten Naesens, Pierre Marquet, Christophe Legendre, Fabiola Terzi, Marion Rabant, Dany Anglicheau
The urinary chemokines CXCL9 and CXCL10 are promising noninvasive diagnostic markers of acute rejection (AR) in kidney recipients, but their levels might be confounded by urinary tract infection (UTI) and BK-virus reactivation. Multiparametric model development and validation addressed these confounding factors in a training set of 391 samples, optimizing the diagnostic performance of urinary chemokines. CXCL9/creatinine increased in UTI and BKV viremia with or without nephropathy (BKVN) (no UTI/leukocyturia/UTI: -0...
April 28, 2020: American Journal of Transplantation