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https://www.readbyqxmd.com/read/29774809/robotic-partial-nephrectomy-for-a-peripheral-renal-tumor
#1
Caleb A Cooper, Cheuk Fan Shum, Chandru P Sundaram
Partial nephrectomy (PN) is the preferred surgical treatment for T1 renal tumors whenever technically feasible. When properly performed, it allows preservation of nephron mass without compromising oncologic outcomes. This reduces the postoperative risk of renal insufficiency, which translates into better overall survival for the patients. PN can be technically challenging, because it requires the surgeon to complete the tasks of tumor excision, hemostasis and renorrhaphy, all within an ischemic time of preferably below 30 minutes...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29771474/neurocog-fx-study-a-multicenter-cohort-study-on-cognitive-dysfunction-in-patients-with-early-breast-cancer
#2
Oliver Rick, Monika Reuß-Borst, Timm Dauelsberg, Holger Hass, Volker König, Reiner Caspari, Gabriele Götz-Keil, Jürgen Pfitzner, Christa Kerschgens, Klaus Fliessbach, Christian Hoppe
OBJECTIVE: Complaints about cognitive dysfunction (CD) reportedly persist in approximately one third of breast cancer patients but the nature of CD and possible risk factors are unknown. METHODS: A cross-sectional, multicenter study was set-up at 9 German oncological rehabilitation centers. Objective cognitive performance was assessed by the NeuroCog FX test, a short computerized screening (duration <30 min) which assesses working memory, alertness, verbal/figural memory and language/executive...
May 17, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29770305/the-prostate-cancer-focal-therapy
#3
REVIEW
Filippo Pesapane, Francesca Patella, Enrico Maria Fumarola, Edoardo Zanchetta, Chiara Floridi, Gianpaolo Carrafiello, Chloë Standaert
Despite prostate cancer (PCa) is the leading form of non-cutaneous cancer in men, most patients with PCa die with disease rather than of the disease. Therefore, the risk of overtreatment should be considered by clinicians who have to distinguish between patients with high risk PCa (who would benefit from radical treatment) and patients who may be managed more conservatively, such as through active surveillance or emerging focal therapy (FT). The aim of FT is to eradicate clinically significant disease while protecting key genito-urinary structures and function from injury...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29769055/one-visceral-artery-may-be-enough-successful-pancreatectomy-in-a-patient-with-total-occlusion-of-the-celiac-and-superior-mesenteric-arteries
#4
Evangelos Tagkalos, Florian Jungmann, Hauke Lang, Stefan Heinrich
BACKGROUND: The anatomic variations of the visceral arteries are not uncommon. The liver arterial blood supply shows 50% variability between humans, with the most common anatomy being one hepatic artery arising from the celiac trunk and one pancreatico-duodenal arcade between the celiac trunk and the superior mesenteric artery. Occlusion of one artery are mostly asymptomatic but may become clinically relevant when surgery of the liver, bile duct or the pancreas is required. If these pathologies are not reversible, an oncologic pancreatic head resection cannot be performed...
May 16, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29764158/what-is-the-role-of-immunotherapy-in-breast-cancer
#5
Tira J Tan, Jack J Chan, Sulastri Kamis, Rebecca Alexandra Dent
The immune system plays a complex role in the recognition/prevention, early eradication as well as progression of cancer. Recently, we have witnessed great momentum in the field of immuno-oncology. Checkpoint inhibitors and chimeric antigen receptor T cell therapy have now entered the clinic, with impressive and durable clinical responses seen across a broad array of tumor types. There are several lines of evidence supporting the development of an immune targeted approach in breast cancer. Emerging data of early clinical trials evaluating monotherapy checkpoint inhibition have shown modest activity in breast cancer, in particular high grade and aggressive subtypes such as triple negative, human epidermal growth factor receptor 2 (HER2)-positive and luminal B breast cancers...
April 2018: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29755780/appendiceal-diverticulosis-a-harbinger-of-underlying-primary-appendiceal-adenocarcinoma
#6
Jia Lin Ng, Shing Lih Wong, Ronnie Mathew
Diagnosis of primary appendiceal adenocarcinoma (PAA) is hindered by its rarity and largely asymptomatic nature. Appendiceal diverticulosis (AD) is equally rare. We report an unusual case of PAA presenting with perforated appendiceal diverticulitis, and discuss a review of the literature about its association, and its surgical and pathological implications. A middle-aged man was admitted with right iliac fossa (RIF) pain and a corresponding tender abdominal mass for 5 days. Computerised tomography (CT) scan demonstrated a thickened appendix with 3 cm abscess at its base...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29752960/assessment-of-herb-drug-synergy-to-combat-doxorubicin-induced-cardiotoxicity
#7
Aditi Jain, Vibha Rani
Aim Doxorubicin (Dox) is one of the most cardiotoxic anti-cancerous drug that is widely used for broad-range of cancers. There is an urgent need for developing cardio-oncological therapeutic interventions. Natural products having both anti-cancerous potential as well as cardioprotective effects may hold a great potential in this regard. Curcuma longa (an Indian herb) polyphenols including curcumin, and well known for its anti-oxidative and anti-cancerous potential was used in the present study for its synergistic effect on cancer cells and cardiomyocytes...
May 9, 2018: Life Sciences
https://www.readbyqxmd.com/read/29752199/gemcitabine-oxaliplatin-plus-rituximab-r-gemox-as-first-line-treatment-in-elderly-patients-with-diffuse-large-b-cell-lymphoma-a-single-arm-open-label-phase-2-trial
#8
Qiu-Dan Shen, Hua-Yuan Zhu, Li Wang, Lei Fan, Jin-Hua Liang, Lei Cao, Wei Wu, Yi Xia, Jian-Yong Li, Wei Xu
BACKGROUND: The combination of rituximab, gemcitabine, and oxaliplatin (R-GemOx) has shown high efficacy with a low toxicity profile in elderly patients with relapsed and refractory diffuse large B-cell lymphoma. We aimed to evaluate the efficacy, safety, and feasibility of the R-GemOx regimen as a first-line treatment in elderly patients with diffuse large B-cell lymphoma. METHODS: In this single-arm, open-label, phase 2 clinical trial, we enrolled patients with previously untreated, histologically confirmed, CD20-positive diffuse large B-cell lymphoma, aged 70 years or older, or aged 60-69 years with an Eastern Cooperative Oncology Group (ECOG) performance status score of 2 or greater...
May 8, 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29749774/bladder-cancer-overview-and-disease-management-part-1-non-muscle-invasive-bladder-cancer
#9
Beverley Anderson
Part 1 of this two-part article provides an overview of bladder cancer and discusses its management. Since publication of a previous article entitled 'Understanding the role of smoking in the aetiology of bladder cancer' ( Anderson, 2009 ), the author has received many requests for an update. This article provides an overview of bladder cancer and its current management practices, underlining the continued role of smoking as the predominant risk factor in the disease's development. The management of bladder cancer is governed by specific guidelines...
May 10, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29748739/anticalin-%C3%A2-proteins-as-therapeutic-agents-in-human-diseases
#10
REVIEW
Christine Rothe, Arne Skerra
Anticalin proteins are an emerging class of clinical-stage biopharmaceuticals with high potential as an alternative to antibodies. Anticalin molecules are generated by combinatorial design from natural lipocalins, which are abundant plasma proteins in humans, and reveal a simple, compact fold dominated by a central β-barrel, supporting four structurally variable loops that form a binding site. Reshaping of this loop region results in Anticalin proteins that can recognize and tightly bind a wide range of medically relevant targets, from small molecules to peptides and proteins, as validated by X-ray structural analysis...
May 10, 2018: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/29743988/molecular-mechanisms-underlying-curcumin-mediated-therapeutic-effects-in-type-2-diabetes-and-cancer
#11
REVIEW
Marzena Wojcik, Michal Krawczyk, Pawel Wojcik, Katarzyna Cypryk, Lucyna Alicja Wozniak
The growing prevalence of age-related diseases, especially type 2 diabetes mellitus (T2DM) and cancer, has become global health and economic problems. Due to multifactorial nature of both diseases, their pathophysiology is not completely understood so far. Compelling evidence indicates that increased oxidative stress, resulting from an imbalance between production of reactive oxygen species (ROS) and their clearance by antioxidant defense mechanisms, as well as the proinflammatory state contributes to the development and progression of the diseases...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29743943/risk-sharing-agreements-present-and-future
#12
REVIEW
Francisco R Gonçalves, Susana Santos, Catarina Silva, Gabriela Sousa
Risk-sharing agreements between pharmaceutical companies and payers stand out as a recent practice, the use of which has been increasing in the case of innovative medicines, particularly in the field of oncology, which aims to ensure better budgetary control and a lower risk of spending on medicinal products without full evidence of clinical benefit. In this article, the authors discuss the types of existing agreements, as well as those used in Portugal, their advantages, disadvantages and future challenges of implementation, as well as their potential role in access to therapeutic innovation, namely medicines for cancer treatment...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29742686/a-rare-case-report-of-one-stage-surgical-treatment-for-left-renal-cell-carcinoma-with-level-iv-intravenous-tumor-thrombus-combined-with-severe-coronary-artery-stenosis
#13
Zhenqing Wang, Keqin Zhang, Hui Zhang, Dingqi Sun, Yong Li, Qi Tan, Qiang Fu
RATIONALE: Renal cell carcinoma (RCC) exhibits a natural tendency to extend from the kidney into inferior vena cava (IVC) and growing into the right atrium is a rare complication. We report a 65-year-old patient with an RCC with intravascular extension through renal vein into the IVC and right atrial combined with severe coronary artery disease. This case has not been described in the literature and there is no treatment guideline for it. PATIENT CONCERNS: A 65-year-old patient was admitted to our clinic with complaints of edema of both lower extremities...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29740450/a-novel-three-dimensional-immune-oncology-model-for-high-throughput-testing-of-tumoricidal-activity
#14
Hilary Sherman, Hannah J Gitschier, Ann E Rossi
The latest advancements in oncology research are focused on autologous immune cell therapy. However, the effectiveness of this type of immunotherapy for cancer remediation is not equivalent for all patients or cancer types. This suggests the need for better preclinical screening models that more closely recapitulate in vivo tumor biology. The established method for investigating tumoricidal activity of immunotherapies has been study of two-dimensional (2D) monolayer cultures of immortalized cancer cell lines or primary tumor cells in standard tissue culture vessels...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29735363/host-dependent-variables-the-missing-link-to-personalized-medicine
#15
REVIEW
Regina Demlova, Lenka Zdrazilova-Dubska, Jaroslav Sterba, Giorgio Stanta, Dalibor Valik
Individualized medicine has the potential to tailor anticancer therapy with the best response and highest safety margin to provide better patient care. However, modern targeted therapies are still being tested through clinical trials comparing preselected patient cohorts and assessed upon behaviour of group averages. Clinically manifesting malignant disease requires identification of host- and tumour-dependent variables such as biological characteristics of the tumour and its microenvironment including immune response features, and overall capacity of the host to receive, tolerate and efficiently utilize treatment...
April 26, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29732738/starvation-tactics-using-natural-compounds-for-advanced-cancers-pharmacodynamics-clinical-efficacy-and-predictive-biomarkers
#16
REVIEW
Khalid El Bairi, Mariam Amrani, Said Afqir
The high mortality associated with oncological diseases is mostly due to tumors in advanced stages, and their management is a major challenge in modern oncology. Angiogenesis is a defined hallmark of cancer and predisposes to metastatic invasion and dissemination and is therefore an important druggable target for cancer drug discovery. Recently, because of drug resistance and poor prognosis, new anticancer drugs from natural sources targeting tumor vessels have attracted more attention and have been used in several randomized and controlled clinical trials as therapeutic options...
May 6, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29730298/exploring-the-biophysical-properties-of-phytosterols-in-the-plasma-membrane-for-novel-cancer-prevention-strategies
#17
REVIEW
Omar Fakih, Didem Sanver, David Kane, James L Thorne
Cancer is a global problem with no sign that incidences are reducing. The great costs associated with curing cancer, through developing novel treatments and applying patented therapies, is an increasing burden to developed and developing nations alike. These financial and societal problems will be alleviated by research efforts into prevention, or treatments that utilise off-patent or repurposed agents. Phytosterols are natural components of the diet found in an array of seeds, nuts and vegetables and have been added to several consumer food products for the management of cardio-vascular disease through their ability to lower LDL-cholesterol levels...
May 3, 2018: Biochimie
https://www.readbyqxmd.com/read/29726723/surgical-approaches-for-the-treatment-of-perihilar-cholangiocarcinoma
#18
Charles W Kimbrough, Jordan M Cloyd, Timothy M Pawlik
Since their initial description, perihilar cholangiocarcinoma (pCCA) has remained one of the more clinically challenging scenarios encountered by hepatobiliary surgeons. Surgery remains the only potentially curative therapy, but requires complex, technically demanding operations with high associated morbidity and mortality. Over the last several decades, advances in surgical technique and perioperative management have improved patient outcomes. Areas Covered: Achievement of optimal outcomes requires a multidisciplinary approach from a team of providers with expertise in hepatobiliary and oncologic surgery, medical oncology, radiation oncology, and advanced gastroenterology...
May 4, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29726358/how-advances-in-imaging-will-affect-precision-radiation-oncology
#19
David A Jaffray, Shiva Das, Paula M Jacobs, Robert Jeraj, Philippe Lambin
Radiation oncology is 1 of the most structured disciplines in medicine. It is of a highly technical nature with reliance on robotic systems to deliver intervention, engagement of diverse expertise, and early adoption of digital approaches to optimize and execute the application of this highly effective cancer treatment. As a localized intervention, the dependence on sensitive, specific, and accurate imaging to define the extent of disease, its heterogeneity, and adjacency to normal tissues directly affects the therapeutic ratio...
June 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29723225/survival-outcomes-in-patients-with-large-%C3%A2-7cm-clear-cell-renal-cell-carcinomas-treated-with-nephron-sparing-surgery-versus-radical-nephrectomy-results-of-a-multicenter-cohort-with-long-term-follow-up
#20
M W W Janssen, J Linxweiler, S Terwey, S Rugge, C-H Ohlmann, F Becker, Ch Thomas, A Neisius, J W Thüroff, S Siemer, M Stöckle, F C Roos
BACKGROUND: Does the dogma of nephron sparing surgery (NSS) still stand for large renal masses? Available studies dealing with that issue are considerably biased often mixing imperative with elective indications for NSS and also including less malignant variants or even benign renal tumors. Here, we analyzed the oncological long-term outcomes of patients undergoing elective NSS or radical tumor nephrectomy (RN) for non-endophytic, large (≥7cm) clear cell renal carcinoma (ccRCC). METHODS: Prospectively acquired, clinical databases from two academic high-volume centers were screened for patients from 1980 to 2010...
2018: PloS One
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