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https://www.readbyqxmd.com/read/28933226/nursing-adherence-to-ethical-codes-in-pediatric-oncology-wards
#1
Raziyeh Beykmirza, Lida Nikfarid, Foroozan Atashzadeh-Shoorideh, Maliheh Nasiri
BACKGROUND: The nature of children's cancer comes with lots of ethical issues. Nurses are encouraged to adhere to ethical codes in their practice. OBJECTIVES: This study aimed to compare the perspectives of nurses and mothers of children with cancer regarding the adherence of nurses to ethical codes. RESEARCH DESIGN: In this descriptive-comparative study, a researcher-made questionnaire was used to assess the amount of adherence to Iranian nurses' code of ethics in perspectives of pediatric oncology nurses and mothers...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28933175/-hiv-infection-a-new-disease-of-internal-medicine
#2
Svatava Snopková
Modern antiretroviral treatment belongs to the greatest success of current medicine. HIV infection has gone from a death sentence to a manageable chronic disease which develops several decades. Thanks to treatment advances, people with HIV can and do live long and full lives. In the last two decades, the incidence AIDS defining illnesses have been dramatically reduced especially opportunistic infections and malignancies, whereas the role of non-infection comorbidities has risen than age-matched HIV uninfected adults...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28932737/technical-intraoperative-maneuvers-for-the-management-of-inferior-vena-cava-thrombus-in-renal-cell-carcinoma
#3
Dionysios Dellaportas, Nikolaos Arkadopoulos, Ioannis Tzanoglou, Evgenios Bairamidis, George Gemenetzis, Pantelis Xanthakos, Constantinos Nastos, Georgia Kostopanagiotou, Ioannis Vassiliou, Vassilios Smyrniotis
INTRODUCTION: Renal vein or inferior vena cava (IVC) invasion by neoplastic thrombus in patients with renal cell carcinoma (RCC) is not an obstacle for radical oncological treatment. The aim of this study is to present our technical maneuvers for complete removal of the intracaval thrombus without compromising hemodymanic stability of the patient. MATERIALS AND METHODS: Between 2000 and 2014, 15 RCC patients with IVC involvement of levels I-III were treated with curative intent and were prospectively studied...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28929270/mode-of-treatment-governs-curcumin-response-on-doxorubicin-induced-toxicity-in-cardiomyoblasts
#4
Aditi Jain, Vibha Rani
Doxorubicin (Dox) is an effective anti-cancer drug with severe reported cardiotoxicity. Cardiovascular risks associated with present cancer therapeutics demand urgent attention. There has been a growing interest in naturally occurring compounds to improve the therapeutic index as well as prevent non-tumour tissues from sustaining chemotherapy-induced damages. In the present study, the effects of curcumin, a polyphenol isolated from Curcuma longa and well known for its anti-oxidative, anti-cancerous and anti-inflammatory properties, was studied in relation to the Dox-induced cardiotoxicity...
September 19, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28926426/epigenetics-and-precision-oncology
#5
Rachael J Werner, Andrew D Kelly, Jean-Pierre J Issa
Epigenetic alterations such as DNA methylation defects and aberrant covalent histone modifications occur within all cancers and are selected for throughout the natural history of tumor formation, with changes being detectable in early onset, progression, and ultimately recurrence and metastasis. The ascertainment and use of these marks to identify at-risk patient populations, refine diagnostic criteria, and provide prognostic and predictive factors to guide treatment decisions are of growing clinical relevance...
September 2017: Cancer Journal
https://www.readbyqxmd.com/read/28922023/fatty-acid-synthase-fasn-as-a-therapeutic-target-in-breast-cancer
#6
Javier A Menendez, Ruth Lupu
Ten years ago, we put forward the metabolo-oncogenic nature of fatty acid synthase (FASN) in breast cancer. Since the conception of this hypothesis, which provided a model to explain how FASN is intertwined with various signaling networks to cell-autonomously regulate breast cancer initiation and progression, FASN has received considerable attention as a therapeutic target. However, despite the ever-growing evidence demonstrating the involvement of FASN as part of the cancer-associated metabolic reprogramming, translation of the basic science-discovery aspects of FASN blockade to the clinical arena remains a challenge...
September 18, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28921644/clinical-pharmacology-considerations-for-the-development-of-immune-checkpoint-inhibitors
#7
Jennifer Sheng, Shivani Srivastava, Kinjal Sanghavi, Zheng Lu, Brian J Schmidt, Akintunde Bello, Manish Gupta
Immuno-oncology works through activation of the patient's immune system against cancer, with several advantages over other treatment approaches, including cytotoxic agents and molecular-targeted therapies. The most notable feature of immuno-oncology treatments is the nature of the patient responses achieved, which can be more durable and sustained than with other modalities. Increased understanding of immune system complexity has provided a number of opportunities to advance several strategies for the development of immuno-oncology therapies...
October 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28921444/polyester-based-nanoparticles-for-delivery-of-therapeutic-proteins
#8
Pedro Fonte, Flávia Sousa, Bruno Sarmento
Therapeutic proteins are widely used to treat severe conditions, such as oncologic and metabolic diseases, and also for vaccination. They are recognized for its high biopotency, but their hydrophilicity and high molecular weight make its transport through membranes difficult to achieve. They may also suffer in vivo structural instability caused by a proteolytic cleavage, turning them biological inactive. Polyester-based nanoparticles are useful tools to overcome such problems, and deliver therapeutic proteins in a controlled and localized manner, decreasing the number of administrations needed and enhancing the therapeutic outcome...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28919884/secretome-of-intestinal-bacilli-a-natural-guard-against-pathologies
#9
REVIEW
Olga N Ilinskaya, Vera V Ulyanova, Dina R Yarullina, Ilgiz G Gataullin
Current studies of human gut microbiome usually do not consider the special functional role of transient microbiota, although some of its members remain in the host for a long time and produce broad spectrum of biologically active substances. Getting into the gastrointestinal tract (GIT) with food, water and probiotic preparations, two representatives of Bacilli class, genera Bacillus and Lactobacillus, colonize epithelium blurring the boundaries between resident and transient microbiota. Despite their minor proportion in the microbiome composition, these bacteria can significantly affect both the intestinal microbiota and the entire body thanks to a wide range of secreted compounds...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28917595/perioperative-and-oncologic-outcomes-of-nephrectomy-and-caval-thrombectomy-using-extracorporeal-circulation-and-deep-hypothermic-circulatory-arrest-for-renal-cell-carcinoma-invading-the-supradiaphragmatic-inferior-vena-cava-and-or-right-atrium
#10
Alessandro Nini, Umberto Capitanio, Alessandro Larcher, Paolo Dell'Oglio, Federico Dehò, Nazareno Suardi, Fabio Muttin, Cristina Carenzi, Massimo Freschi, Roberta Lucianò, Giovanni La Croce, Alberto Briganti, Renzo Colombo, Andrea Salonia, Alessandro Castiglioni, Patrizio Rigatti, Francesco Montorsi, Roberto Bertini
BACKGROUND: Radical nephrectomy (RN) and caval thrombectomy (CT) for renal cell carcinoma, with extracorporeal circulation (ECC) and deep hypothermic circulatory arrest (DHCA) is a challenging surgical approach. OBJECTIVE: To assess peri-operative and oncologic outcomes of renal cell carcinoma patients treated with RN and CT, using ECC and DHCA. DESIGN, SETTING, AND PARTICIPANTS: We retrospectively evaluated 46 patients who underwent RN and CT using ECC and DHCA...
September 13, 2017: European Urology
https://www.readbyqxmd.com/read/28913732/patient-and-provider-perceptions-of-internet-delivered-cognitive-behavior-therapy-for-recent-cancer-survivors
#11
Nicole M Alberts, Heather D Hadjistavropoulos, Nickolai Titov, Blake F Dear
PURPOSE: Although most cancer survivors adjust well, a subset experiences clinical levels of anxiety and depression following cancer treatment. Internet-delivered cognitive behavior therapy (iCBT) is a promising intervention for symptoms of anxiety and depression among survivors; however, patient and provider perceptions of iCBT have not been examined. METHODS: We employed an exploratory qualitative method and conducted semi-structured interviews with 13 cancer survivors and 10 providers to examine iCBT strengths and weaknesses, areas for improvement, and perceived barriers to program completion...
September 15, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28894736/synthetic-gene-expression-circuits-for-designing-precision-tools-in-oncology
#12
REVIEW
Angela Re
Precision medicine in oncology needs to enhance its capabilities to match diagnostic and therapeutic technologies to individual patients. Synthetic biology streamlines the design and construction of functionalized devices through standardization and rational engineering of basic biological elements decoupled from their natural context. Remarkable improvements have opened the prospects for the availability of synthetic devices of enhanced mechanism clarity, robustness, sensitivity, as well as scalability and portability, which might bring new capabilities in precision cancer medicine implementations...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28885872/teaching-tip-simulated-tumors-as-an-aid-to-teaching-principles-of-surgical-oncology
#13
Christopher Tan, Rachel Basa, Peter Bennett, Neil Hannan, William R Walsh, Christopher Bellenger
Tumors of the skin and subcutaneous tissues are an important cause of morbidity and mortality in small animals. In many cases, surgical excision is an essential component of successful therapy and it should be performed in a specific way based on the type and grade of the tumor. Students require adequate training to develop both clinical decision-making skills and technical surgical skills, which we believe contribute to optimal clinical results. We have developed an inexpensive and simple technique that aims to replicate a naturally occurring subcutaneous tumor and allows trainees to plan and perform three common surgical procedures: incisional biopsy, marginal excision, and wide surgical excision...
September 8, 2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28870891/lidocaine-stimulates-the-function-of-natural-killer-cells-in-different-experimental-settings
#14
REVIEW
Juan P Cata, Maria F Ramirez, Jose F Velasquez, A I Di, Keyuri U Popat, Vijaya Gottumukkala, Dahlia M Black, Valerae O Lewis, Jean N Vauthey
BACKGROUND: One of the functions of natural killer (NK) cells is to eliminate cancer cells. The cytolytic activity of NK cells is tightly regulated by inhibitory and activation receptors located in the surface membrane. Lidocaine stimulates the function of NK cells at clinically relevant concentrations. It remains unknown whether this effect of lidocaine has an impact on the expression of surface receptors of NK cells, can uniformly stimulate across different cancer cell lines, and enhances the function of cells obtained during oncological surgery...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28869204/safety-of-live-robotic-surgery-results-from-a-single-institution
#15
Gabriel Ogaya-Pinies, Haidar Abdul-Muhsin, Hariharan Palayapalayam-Ganapathi, Xavier Bonet, Travis Rogers, Bernardo Rocco, Rafael Coelho, Eduardo Hernandez-Cardona, Cathy Jenson, Vipul Patel
BACKGROUND: Live surgery events (LSEs) have become one of the most attended activities at surgical meetings and provide a unique opportunity for the audience to observe the decision-making process used by skilled and experienced surgeons in real time. However, there is an ongoing discussion on whether patients treated during LSE are at higher risk of complications. OBJECTIVE: To examine LSE outcomes for robot-assisted radical prostatectomy (RARP) and establish patient safety and efficacy...
August 28, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28864405/ischemic-cardiac-events-following-treatment-of-the-internal-mammary-nodal-region-using-contemporary-radiation-planning-techniques
#16
Robert T Dess, Adam L Liss, Kent A Griffith, Robin B Marsh, Jean M Moran, Charles Mayo, Todd M Koelling, Reshma Jagsi, James A Hayman, Lori J Pierce
PURPOSE: Regional nodal irradiation, including radiation therapy (RT) to the internal mammary node (IMN) region, improves oncologic outcomes in patients with node-positive breast cancer. Concern remains, however, given the proximity of the IMNs to the heart and the association between cardiac RT exposure and toxicity. The objective of the study was to evaluate rates of ischemic cardiac events (ICEs) and associated risk with treatment of the IMN region. METHODS AND MATERIALS: The cardiac outcomes of 2126 patients treated with adjuvant breast RT or breast and nodal RT from 1984 to 2007 at a single institution were reviewed...
June 27, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28862765/an-fmea-evaluation-of-intensity-modulated-radiation-therapy-dose-delivery-failures-at-tolerance-criteria-levels
#17
Jacqueline Tonigan Faught, Peter A Balter, Jennifer L Johnson, Stephen F Kry, Laurence E Court, Francesco C Stingo, David S Followill
PURPOSE: The objective of this work was to assess both the perception of failure modes in Intensity Modulated Radiation Therapy (IMRT) when the linac is operated at the edge of tolerance given in AAPM TG-40(1) and TG-142(2) as well as the application of FMEA to this specific section of the IMRT process. METHODS: An online survey was distributed to approximately 2000 physicists worldwide that participate in quality services provided by the Imaging and Radiation Oncology Core - Houston (IROC-H)...
September 1, 2017: Medical Physics
https://www.readbyqxmd.com/read/28862198/physical-activity-influences-the-immune-system-of-breast-cancer-patients
#18
REVIEW
Thorsten Schmidt, Marion van Mackelenbergh, Daniela Wesch, Christoph Mundhenke
It has been suggested that physical activity in breast cancer patients can not only improve quality of life. Influences on physical and psychological levels have been evaluated, but effects on the immune system of breast cancer patients are hardly known. A PubMed search identified relevant trials and meta-analyses from 1970 to 2013. This review summarizes the results of international studies and the current discussion of effects of physical activity on the immune system of breast cancer patients. Highlighted are effects of physical activity on the immune system...
July 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28862123/results-of-1-year-diet-and-exercise-interventions-for-er-pr%C3%A2-her2-breast-cancer-patients-correlated-with-treatment-type
#19
Diana V Artene, Cristian I Bordea, Alexandru Blidaru
PURPOSE: Many breast cancer patients gain weight during chemotherapy and antiestrogenic treatment increasing recurrence, oncologic specific and all-cause mortality risks. Patients and Methods: 165 ER+/PR±/HER2- breast cancer patients under antiestrogenic treatment were randomly assigned to follow an at-home diet based on food naturally high in proteins, calcium, probiotics and prebiotics (D), or this diet and 4' isometric exercises (D+Ex) for 1 year. We measured weight (W), body (BF) and visceral fat (VF) using a multi-frequency bioelectrical impedance scale on the 6th and 12th month and we correlated results with chemotherapy, surgery and antiestrogenic medication type...
July 2017: Chirurgia
https://www.readbyqxmd.com/read/28862114/immediate-delayed-autologous-ideal-breast-reconstruction-with-the-diep-flap
#20
Sonia Fertsch, Beatrix Munder, Mazen Hagouan, Tino Schulz, Oliver Thamm, Peter Stambera, Alina Abu-Ghazaleh, Julia Schaberick, Christoph Andree
Background: The most common cancer worldwide in women is breast cancer. The increasing number of cases each year, requires a novel curative approach that can combine oncological treatments and breast reconstruction yielding a pleasing and aesthetic breast that is a definitive and long lasting solution. Thus, the Immediate-DElayed AutoLogous (IDEAL) breast reconstruction principle was created to hold up to the standards of the needs of contemporary women. METHOD: The IDEAL protocol for breast reconstruction was developed in our department in cooperation with our breast surgery unit and describes a two-stage approach that implicates neoadjuvant radio-/ chemotherapy treatment regimes and tumor staging before the mastectomy in order to avoid post-mastectomy radiation...
July 2017: Chirurgia
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