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https://www.readbyqxmd.com/read/29150095/-towards-a-better-use-of-midazolam-in-end-of-life-a-survey-in-a-department-of-medical-oncology
#1
Aurélie Beneton, Alexis Vallard, Christelle Brosse, Géraldine Poenou, Cécile Pacaut, Nicolas Magné, Stéphanie Morisson
INTRODUCTION: At the end of life of cancer patients, sedation is sometimes needed, in order to palliate unbearable symptoms that other treatments fail to relieve. Midazolam is currently recommended for sedation and its prescription is guided by national guidelines. The aim of the present study was to evaluate the practices of midazolam prescription in a department of medical oncology and to compare the results with French national recommendations in order to improve the midazolam use in case of sedation...
November 14, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29141560/growth-kinetics-and-oncologic-outcomes-for-small-renal-masses-managed-with-active-surveillance-a-review-of-the-literature
#2
Benjamin T Ristau, Thomas W Fuller, Ricardo Rios, Cristina Ho, Jeffrey J Tomaszewski
An increasing number of enhancing renal masses are being discovered incidentally on cross-sectional imaging. Many can be characterized as small renal masses (SRMs), the natural history of which is heterogeneous and poorly understood. Active surveillance has been proposed as an initial management strategy for these tumors, particularly in the old and infirmed patient population. Herein, a rigorous review of the literature is provided to explore the incidence and epidemiology of SRMs as well as the growth kinetics and oncologic outcomes of SRMs under observation...
November 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29140493/a-comprehensive-definition-for-integrative-oncology
#3
Claudia M Witt, Lynda G Balneaves, Maria J Cardoso, Lorenzo Cohen, Heather Greenlee, Peter Johnstone, Ömer Kücük, Josh Mailman, Jun J Mao
Background: Integrative oncology, which is generally understood to refer to the use of a combination of complementary medicine therapies in conjunction with conventional cancer treatments, has been defined in different ways, but there is no widely accepted definition. We sought to develop and establish a consensus for a comprehensive definition of the field of integrative oncology. Methods: We used a mixed-methods approach that included a literature analysis and a consensus procedure, including an interdisciplinary expert panel and surveys, to develop a comprehensive and acceptable definition for the term "integrative oncology...
November 1, 2017: Journal of the National Cancer Institute. Monographs
https://www.readbyqxmd.com/read/29140430/the-european-society-for-medical-oncology-esmo-precision-medicine-glossary
#4
L R Yates, J Seoane, C Le Tourneau, L L Siu, R Marais, S Michiels, J C Soria, P Campbell, N Normanno, A Scarpa, J S Reis-Filho, J Rodon, C Swanton, F Andre
Background: Precision medicine is rapidly evolving within the field of oncology and has brought many new concepts and terminologies that are often poorly defined when first introduced, which may subsequently lead to miscommunication within the oncology community. The European Society for Medical Oncology (ESMO) recognises these challenges and is committed to support the adoption of precision medicine in oncology. To add clarity to the language used by oncologists and basic scientists within the context of precision medicine, the ESMO Translational Research and Personalised Medicine Working Group has developed a standardised glossary of relevant terms...
November 13, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29136276/targeted-therapies-immunologic-effects-and-potential-applications-outside-of-cancer
#5
REVIEW
Anna E Kersh, Spencer Ng, Yun Min Chang, Maiko Sasaki, Susan N Thomas, Haydn T Kissick, Gregory B Lesinski, Ragini R Kudchadkar, Edmund K Waller, Brian P Pollack
Two pharmacologic approaches that are currently at the forefront of treating advanced cancer are those that center on disrupting critical growth/survival signaling pathways within tumor cells (commonly referred to as "targeted therapies") and those that center on enhancing the capacity of a patient's immune system to mount an antitumor response (immunotherapy). Maximizing responses to both of these approaches requires an understanding of the oncogenic events present in a given patient's tumor and the nature of the tumor-immune microenvironment...
November 14, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29134826/cancer-patients-recommendations-for-nature-based-design-and-engagement-in-oncology-contexts-qualitative-research
#6
Sarah Blaschke, Clare C O'Callaghan, Penelope Schofield
OBJECTIVES: To explore cancer patients' recommendations for nature engagement based on their subjective nature experiences and observations in the cancer setting. The rationale was to gain practical insight for delineating relevant and translatable nature-based care and design opportunities in oncology contexts. BACKGROUND: Innovative cancer care services are needed to respond to growing demand and shifting healthcare needs. Engagement with nature has shown multiple health benefits and presents a promising opportunity for application in healthcare to improve outcomes...
January 1, 2017: HERD
https://www.readbyqxmd.com/read/29107525/mindful-communication-being-present
#7
REVIEW
Maryjo Prince-Paul, Carol Kelley
OBJECTIVES: To review how mindfulness can be elicited in and strategically managed through communication, with a goal toward enhancing the patient/family relationship in the experience of cancer care. DATA SOURCES: Published, peer-reviewed literature, research reports, and Web-based resources. CONCLUSION: Mindful communication, an active process whereby the health care provider and patient /family unit are attentive to the timing, nature, and context of the dialogue exchange, helps direct care that is patient-centered, reflective, and relational...
October 26, 2017: Seminars in Oncology Nursing
https://www.readbyqxmd.com/read/29104835/online-adaptive-radiation-therapy-implementation-of-a-new-process-of-care
#8
James Lamb, Minsong Cao, Amar Kishan, Nzhde Agazaryan, David H Thomas, Narek Shaverdian, Yingli Yang, Suzette Ray, Daniel A Low, Ann Raldow, Michael L Steinberg, Percy Lee
Onboard magnetic resonance imaging (MRI) guided radiotherapy is now clinically available in nine centers in the world. This technology has facilitated the clinical implementation of online adaptive radiotherapy (OART), or the ability to alter the daily treatment plan based on tumor and anatomical changes in real-time while the patient is on the treatment table. However, due to the time sensitive nature of OART, implementation in a large and busy clinic has many potential obstacles as well as patient-related safety considerations...
August 27, 2017: Curēus
https://www.readbyqxmd.com/read/29090562/-overview-of-research-projects-funding-in-traditional-chinese-medicine-oncology-field-supported-by-national-natural-science-foundation-of-china
#9
Dong-Xin Tang, Lian-Yu Chen, Shu-Zhen Guo, Li-Wei Han, Feng-Zhu Zhang
In this paper, the funding situation of traditional Chinese medicine oncology research projects supported by National Natural Science Fund from 1986-2016 was reviewed. The characteristics of funded projects were summarized from funding amount, funding expenses, funding category, and the main research contents of projects, etc. At the same time, the main problems in the projects were analyzed in this paper, in order to provide reference for the relevant fund applicants.
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29081781/antimicrobial-peptides-as-biologic-and-immunotherapeutic-agents-against-cancer-a-comprehensive-overview
#10
REVIEW
Raheleh Roudi, Nicholas L Syn, Maryam Roudbary
Antimicrobial peptides (AMPs) are a pervasive and evolutionarily ancient component of innate host defense which is present in virtually all classes of life. In recent years, evidence has accumulated that parallel or de novo mechanisms by which AMPs curb infectious pathologies are also effective at restraining cancer cell proliferation and dissemination, and have consequently stimulated significant interest in their deployment as novel biologic and immunotherapeutic agents against human malignancies. In this review, we explicate the biochemical underpinnings of their tumor-selectivity, and discuss results of recent clinical trials (outside of oncologic indications) which substantiate their safety and tolerability profiles...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29079959/integrating-natural-language-processing-and-machine-learning-algorithms-to-categorize-oncologic-response-in-radiology-reports
#11
Po-Hao Chen, Hanna Zafar, Maya Galperin-Aizenberg, Tessa Cook
A significant volume of medical data remains unstructured. Natural language processing (NLP) and machine learning (ML) techniques have shown to successfully extract insights from radiology reports. However, the codependent effects of NLP and ML in this context have not been well-studied. Between April 1, 2015 and November 1, 2016, 9418 cross-sectional abdomen/pelvis CT and MR examinations containing our internal structured reporting element for cancer were separated into four categories: Progression, Stable Disease, Improvement, or No Cancer...
October 27, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29078675/advantages-and-disadvantages-of-single-incision-vats-in-major-anatomical-resection-for-lung-cancer
#12
Semih Halezeroğlu
Safety and feasibility of lung resections by single incision thoracoscopy have been confirmed in large number of studies. As proponents claim its lesser invasive nature caused by lacking of additional intercostal port(s), opponents question the outcome measures of the approach especially in oncological manner. Since there is no major discussion regarding the superiority of video-assisted thoracoscopic surgery (VATS) on lung resections over the open technique in the surgical management of lung cancer today, advantage and disadvantage of single incision VATS lung resections was reviewed with the comparison of standard, multi-port VATS approach in this article...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29073725/radiomics-in-paediatric-neuro-oncology-a-multicentre-study-on-mri-texture-analysis
#13
Ahmed E Fetit, Jan Novak, Daniel Rodriguez, Dorothee P Auer, Christopher A Clark, Richard G Grundy, Andrew C Peet, Theodoros N Arvanitis
Brain tumours are the most common solid cancers in children in the UK and are the most common cause of cancer deaths in this age group. Despite current advances in MRI, non-invasive diagnosis of paediatric brain tumours has yet to find its way into routine clinical practice. Radiomics, the high-throughput extraction and analysis of quantitative image features (e.g. texture), offers potential solutions for tumour characterization and decision support. In the search for diagnostic oncological markers, the primary aim of this work was to study the application of MRI texture analysis (TA) for the classification of paediatric brain tumours...
October 26, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29072767/biocompatible-silver-gold-and-silver-gold-alloy-nanoparticles-for-enhanced-cancer-therapy-in-vitro-and-in-vivo-perspectives
#14
Thangavel Shanmugasundaram, Manikkam Radhakrishnan, Venugopal Gopikrishnan, Krishna Kadirvelu, Ramasamy Balagurunathan
The aims of nano oncology are to detect, target and treat cancer cells without any side effects. The present study describes the microbial synthesis of biocompatible nanoparticles of silver (AgNPs), gold (AuNPs) and their alloy (Ag/AuNPs) for hepatoprotective activity against diethylnitrosamine (DEN)-induced liver cancer in a Sprague Dawley (SD) rat model. The crystalline nature and physicochemical features of the nanoparticles were identified by Fourier transform infra-red (FT-IR) spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM) and selected area electron diffraction (SAED) analysis...
November 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/29071484/robotic-right-colectomy-with-intracorporeal-anastomosis-for-malignancy
#15
Scott R Kelley, Emilie Duchalais, David W Larson
Techniques for robotic resection of the right colon have not been extensively published or adopted. We report our initial experience of robotic right colectomy with intracorporeal anastomosis and specimen extraction through a Pfannenstiel incision retrospectively. Twenty-one consecutive patients with a right colon cancer (n = 18) or polyp too large to remove endoscopically (n = 3) were treated at Mayo Clinic Rochester, Minnesota. Main outcomes measured were estimated blood loss, operative time, conversion rate, return of gastrointestinal function, length of stay, overall and severe complications, discharge status, and pathology...
October 25, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29071179/novel-hyaluronic-acid-conjugates-for-dual-nuclear-imaging-and-therapy-in-cd44-expressing-tumors-in-mice-in-vivo
#16
Ravindra Dhar Dubey, Rebecca Klippstein, Julie Tzu-Wen Wang, Naomi Hodgins, Kuo-Ching Mei, Jane Sosabowski, Robert C Hider, Vincenzo Abbate, Prem N Gupta, Khuloud T Al-Jamal
Hyaluronic acid, a natural CD44 receptor ligand, has attracted attention in the past years as a macromolecular delivery of anticancer agents to cancer. At the same time, the clinical applications of Gemcitabine (Gem) have been hindered by its short biological half-life, high dose and development of drug resistance. This work reports the synthesis of a hyaluronic acid (HA) conjugate for nuclear imaging, and in vivo Gem delivery to CD44-expressing solid tumors in mice. HA was individually conjugated, via amide coupling, to Gem (HA-Gem), 4'-(aminomethyl)fluorescein hydrochloride (HA-4'-AMF) or tris(hydroxypyridinone) amine (HA-THP) for cancer therapy, in vitro tracking or single photon emission computed tomography/computed tomography (SPECT/CT) imaging, respectively...
2017: Nanotheranostics
https://www.readbyqxmd.com/read/29066503/chromogranin-a-as-circulating-marker-for-diagnosis-and-management-of-neuroendocrine-neoplasms-more-flaws-than-fame
#17
Vincenzo Marotta, Maria Chiara Zatelli, Concetta Sciammarella, Maria Rosaria Ambrosio, Marta Bondanelli, Annamaria A L Colao, Antongiulio Faggiano
Owing to the heterogeneity of neuroendocrine neoplasms (NENs), the availability of reliable circulating markers is critical for improving diagnostics, prognostic stratification, follow-up, and definition of treatment strategy. This review is focused on Chromogranin A (CgA), a hydrophilic glycoprotein present in large dense core vesicles of neuroendocrine cells. Despite being long identified as the most useful NEN-related circulating marker, clinical application of CgA is controversial. CgA assays still lack of standardization, thus hampering not only clinical management but also the comparison between different analyses...
October 24, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29066046/rationally-designed-hecogenin-thiosemicarbazone-analogs-as-novel-mek-inhibitors-for-the-control-of-breast-malignancies
#18
Heba E Elsayed, Hassan Y Ebrahim, Eman G Haggag, Amel M Kamal, Khalid A El Sayed
Natural products have documented oncology success history as valuable scaffolds for selective target modulation. Herein, the sapogenin hecogenin (1) was screened for its anti-breast cancer inhibitory capacity using in vitro assays, including proliferation, cytotoxicity, migration, invasion assays, and Western blotting. The results identified 1 as a propitious hit with modest activities attributed to the concurrent down-regulation of mitogen activated protein kinase kinase/extracellular signal-regulated kinase (MEK) distinctive downstream effectors...
September 27, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29064921/nipple-sparing-mastectomy-and-direct-to-implant-breast-reconstruction
#19
REVIEW
Amy S Colwell, Joani M Christensen
Breast reconstruction following mastectomy has evolved to preserve the native skin and nipple of the breast and create a natural-appearing reconstruction in 1 or 2 surgeries. Nipple-sparing procedures appear to be oncologically safe with low risks of cancer recurrence. In our series of 2,182 nipple-sparing mastectomies, there was no development or recurrence of cancer in the nipple. Direct-to-implant single-stage surgery offers the patient a complete reconstruction at the time of mastectomy. Patient selection centers on preoperative breast anatomy combined with postoperative goals for size and uplift of the breast...
November 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29059439/real-world-data-for-clinical-evidence-generation-in-oncology
#20
Sean Khozin, Gideon M Blumenthal, Richard Pazdur
Conventional cancer clinical trials can be slow and costly, often produce results with limited external validity, and are difficult for patients to participate in. Recent technological advances and a dynamic policy landscape in the United States have created a fertile ground for the use of real-world data (RWD) to improve current methods of clinical evidence generation. Sources of RWD include electronic health records, insurance claims, patient registries, and digital health solutions outside of conventional clinical trials...
November 1, 2017: Journal of the National Cancer Institute
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