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https://www.readbyqxmd.com/read/27933652/nonobstructive-diffuse-dilated-bowel-loops-prenatal-diagnosis-fetal-characteristics-and-neonatal-outcomes
#1
Guy Katz, Ben Pode-Shakked, Michal Berkenstadt, Ron Bilik, Sylvie Polak Charcon, Iris Barshack, Reuven Achiron, Yinon Gilboa
OBJECTIVES: The purpose of this study was to describe the characteristics and outcomes of fetuses with a diagnosis of nonobstructive diffuse dilated bowel loops. METHODS: We conducted a retrospective study of all pregnancies with fetal diagnosis of nonobstructive diffuse dilated bowel loops over 14 years in a large tertiary referral center. Fetomaternal and neonatal characteristics and outcomes were assessed. RESULTS: Seven fetuses had sonograms showing diffuse dilated bowel loops; none of them had intestinal obstruction after labor...
December 8, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27933431/effect-of-remote-ischaemic-preconditioning-on-liver-injury-in-patients-undergoing-major-hepatectomy-for-colorectal-liver-metastasis-a-pilot-randomised-controlled-feasibility-trial
#2
Sanjeev Kanoria, Francis P Robertson, Naimish N Mehta, Giuseppe Fusai, Dinesh Sharma, Brian R Davidson
BACKGROUND: Liver resection produces excellent long-term survival for patients with colorectal liver metastases but is associated with significant morbidity and mortality from ischaemia reperfusion injury (IRI). Remote ischaemic preconditioning (RIPC) can reduce the effect of IRI. This pilot randomised controlled trial evaluated RIPC in patients undergoing major hepatectomy at the Royal Free Hospital, London. METHODS: Sixteen patients were randomised to RIPC or sham control...
December 8, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27932693/functional-reorganization-is-a-maladaptive-response-to-injury-no
#3
Iris-Katharina Penner, Orhan Aktas
No abstract text is available yet for this article.
December 8, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27932622/inflammasome-activation-underlies-central-nervous-system-deterioration-in-hiv-associated-tuberculosis
#4
Suzaan Marais, Rachel P J Lai, Katalin A Wilkinson, Graeme Meintjes, Anne O'Garra, Robert J Wilkinson
Tuberculosis meningitis (TBM) is a frequent cause of meningitis in HIV-infected individuals, resulting in death in ~ 40% of affected patients. A severe complication of antiretroviral therapy (ART) in these patients is neurological TB-immune reconstitution inflammatory syndrome (IRIS), but its underlying cause remains poorly understood. To investigate the pathogenesis of TBM-IRIS, we performed longitudinal whole blood microarray analysis of HIV-infected TBM patients and reflected the findings at the protein level...
December 8, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27931079/protecting-the-mitochondria-against-ischemia-reperfusion-a-gassy-solution
#5
EDITORIAL
Thierry Hauet, Raphael Thuillier
Organ transplantation success has seen great improvements in past decades due to progresses in immune-suppressive regiments. However, lack of long-term graft outcome improvement, added to increased marginal donors use, has recently shifted the focus towards the peri-transplant period and particularly ischemia reperfusion injury (IRI). The recent acknowledgment of the link between IRI and outcome, short or long term, has rekindled interest in the study of the physiopathology associated with organ preservation and the methods to optimize it...
December 8, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27930783/iris-vascular-tufts
#6
Vasilios P Papastefanou, Christopher K H Burris, Mandeep S Sagoo
No abstract text is available yet for this article.
December 8, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27930384/the-endothelial-mineralocorticoid-receptor-mediator-of-the-switch-from-vascular-health-to-disease
#7
Ana P Davel, Imran J Anwar, Iris Z Jaffe
PURPOSE OF REVIEW: Endothelial dysfunction is an early feature of vascular disease induced by cardiovascular risk factors (CRFs). In growing populations with obesity, diabetes, hypertension, and heart failure, mineralocorticoid receptor antagonism improves endothelial function. This review summarizes recent advances in our understanding of the specific role of endothelial cell mineralocorticoid receptor in vascular function in health and disease. RECENT FINDINGS: Using transgenic mice with mineralocorticoid receptor expression specifically modulated in endothelial cells, recent studies support the emerging concept that while endothelial cell mineralocorticoid receptor may be protective in health, in the presence of CRFs, endothelial cell mineralocorticoid receptor activity contributes to endothelial dysfunction and progression of vascular disease...
December 7, 2016: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/27929720/unclassified-axenfeld-rieger-syndrome-a-case-series-and-review-of-literature
#8
Aparna Rao, Debananda Padhy, Sarada Sarangi, Gopinath Das
PURPOSE: To report anterior segment features in unclassified anterior segment dysgenesis with overlapping features of Axenfeld-Rieger syndrome and other developmental anomalies. METHODS: This retrospective study included those with atypical or overlapping features in one or both eyes, which were identified as unclassified ASD. Typical ARS was defined as the presence of posterior embryotoxon with or without iris changes like stromal hypoplasia, corectopia, polycoria, or ectropion uvea with or without systemic features...
December 8, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27929500/the-dose-penumbra-of-a-custom-made-shield-used-in-hemibody-skin-electron-irradiation
#9
Charlotte I Rivers, Ismail AlDahlawi, Iris Z Wang, Anurag K Singh, Matthew B Podgorsak
We report our technique for hemibody skin electron irradiation with a custom-made plywood shield. The technique is similar to our clinical total skin electron irradiation (TSEI), performed with a six-pair dual field (Stanford technique) at an extended source-to-skin distance (SSD) of 377 cm, with the addition of a plywood shield placed at 50 cm from the patient. The shield is made of three layers of stan-dard 5/8'' thick plywood (total thickness of 4.75 cm) that are clamped securely on an adjustable-height stand...
November 8, 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27929199/platelets-as-a-novel-source-of-gremlin-1-implications-for-thromboinflammation
#10
Madhumita Chatterjee, Alexander Behrendt, Martina Schmid, Sandra Beck, Martina Schneider, Andreas Mack, Iris Müller, Tobias Geisler, Meinrad Gawaz
Platelets mediating haemostasis-thrombosis are central players in coronary artery disease (CAD). We characterised platelets as a novel source of Gremlin-1. Platelets express Gremlin-1 like inflammatory and endothelial cells. Gremlin-1 co-localised with P-selectin containing randomly distributed α-granules under resting state, which were peripheralised following platelet activation or adhesion over fibrinogen-coated surface. Gremlin-1 release upon activation with ADP, CRP, and TRAP was detected as enhanced surface expression; also in activated platelet supernatant as detected by Western Blot following CRP activation and by ELISA upon activation with ADP, CRP, PAR-1, and PAR4 agonist...
December 8, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27927720/restorative-proctocolectomy-in-elderly-ibd-patients-a-multicentre-comparative-study-on-safety-and-efficacy
#11
Francesco Colombo, Saloomeh Sahami, Antony de Buck Van Overstraeten, Hagit Tulchinsky, Diane Mege, Iris Dotan, Diego Foschi, Cosimo Alex Leo, Janindra Warusavitarne, André D'Hoore, Yves Panis, Willem Bemelman, Gianluca M Sampietro
BACKGROUND AND AIMS: Restorative proctocolectomy in elderly inflammatory bowel disease [ IBD] patients is controversial and limited data are available on the outcomes of surgery. The aim of this study was to evaluate the safety, efficacy, and long-term results of ileal-pouch-anal anastomosis in elderly patients, in a multicentre survey from European referral centres. METHODS: The International Pouch Database [IPD] combined 101 variables. Patients aged ≥ 65 years were matched on the basis of open versus laparoscopic surgery with a control group of consecutive younger unselected patients with a ratio of 1:2...
December 7, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27927679/temporal-ocular-coherence-tomography-measured-changes-in-anterior-chamber-angle-and-diurnal-intraocular-pressure-after-laser-iridoplasty-impact-study
#12
Rupert R A Bourne, Ivailo Zhekov, Shahina Pardhan
AIMS: To evaluate temporal change in anterior chamber angle anatomy following argon laser peripheral iridoplasty (ALPI) in eyes with occludable angles postlaser peripheral iridotomy (LPI) compared with control eyes. Additionally, the effect on diurnal intraocular pressure (DIOP) fluctuation (maximum-minimum IOP) was investigated. METHODS: Twenty-two patients with bilateral primary angle closure/suspects with gonioscopically occludable anterior chamber angles following LPI were randomised to receive ALPI (n=11) or no further treatment (n=11)...
December 7, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27927651/dna-repair-in-ischemic-acute-kidney-injury
#13
Jeffrey David Pressly, Frank Park
Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) leading to an induction of oxidative stress, cellular dysfunction and a loss of renal function. DNA damage, including oxidative base modifications and physical DNA strand breaks, is a consequence of renal IRI. Like many other organs in the body, a redundant and highly conserved set of endogenous repair pathways have evolved to selectively recognize the various types of cellular DNA damage and combat its negative effects on cell viability...
December 7, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27927595/decreased-cerebral-perfusion-in-duchenne-muscular-dystrophy-patients
#14
Nathalie Doorenweerd, Eve M Dumas, Eidrees Ghariq, Sophie Schmid, Chiara S M Straathof, Arno A W Roest, Beatrijs H Wokke, Erik W van Zwet, Andrew G Webb, Jos G M Hendriksen, Mark A van Buchem, Jan J G M Verschuuren, Iris Asllani, Erik H Niks, Matthias J P van Osch, Hermien E Kan
Duchenne muscular dystrophy is caused by dystrophin gene mutations which lead to the absence of the protein dystrophin. A significant proportion of patients suffer from learning and behavioural disabilities, in addition to muscle weakness. We have previously shown that these patients have a smaller total brain and grey matter volume, and altered white matter microstructure compared to healthy controls. Patients with more distal gene mutations, predicted to affect dystrophin isoforms Dp140 and Dp427, showed greater grey matter reduction...
October 17, 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/27924932/nadph-oxidase-4-deficiency-increases-tubular-cell-death-during-acute-ischemic-reperfusion-injury
#15
Stellor Nlandu-Khodo, Romain Dissard, Udo Hasler, Matthias Schäfer, Haymo Pircher, Pidder Jansen-Durr, Karl Heinz Krause, Pierre-Yves Martin, Sophie de Seigneux
NADPH oxidase 4 (NOX4) is highly expressed in kidney proximal tubular cells. NOX4 constitutively produces hydrogen peroxide, which may regulate important pro-survival pathways. Renal ischemia reperfusion injury (IRI) is a classical model mimicking human ischemic acute tubular necrosis. We hypothesized that NOX4 plays a protective role in kidney IRI. In wild type (WT) animals subjected to IRI, NOX4 protein expression increased after 24 hours. NOX4 KO (knock-out) and WT littermates mice were subjected to IRI...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924516/carbon-monoxide-inhibits-the-nuclear-cytoplasmic-translocation-of-hmgb1-in-an-in-vitro-oxidative-stress-injury-model-of-mouse-renal-tubular-epithelial-cells
#16
Yu Jia, Lu Wang, Guang-Yuan Zhao, Zhi-Qiang Wang, Song Chen, Gang Chen
Carbon monoxide (CO), as a vital small molecule in signaling pathways, is found to be involved in ischemia-reperfusion injury (IRI) in renal transplantation. CO-releasing molecule-2 (CORM-2), a CO-releasing molecule, is a type of metal carbonyl complexes which can quickly release CO in vivo. In this study, an in vitro oxidative stress injury model was established to examine the effect of CORM-2 pretreatment on the nuclear-cytoplasmic translocation of high mobility group box 1 protein (HMGB1) in mouse primary renal proximal tubular epithelial cells (RPTECs)...
December 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27924123/increased-oxidative-stress-lipid-peroxidation-and-protein-degradation-trigger-senescence-in-iris-versicolor-l-flowers
#17
Syed Sabhi Ahmad, Inayatullah Tahir
Dynamics in various physiological and biochemical aspects were studied during various stages (I-tight bud stage to VI-senescent stage) of flower development in Iris versicolor. Floral diameter, fresh & dry mass and water content increased during flower opening and decreased towards senescence. Senescence was found to be related to the increased lipid peroxidation which was reflected in the decreased membrane stability index towards senescence. This increase in the lipid peroxidation was probably initiated by increased lipoxygenase activity which shot up just prior to the increase in lipid peroxidation...
October 2016: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/27923037/adherence-to-colorectal-cancer-screening-four-rounds-of-faecal-immunochemical-test-based-screening
#18
Manon van der Vlugt, Esmée J Grobbee, Patrick Mm Bossuyt, Evelien Bongers, Wolfert Spijker, Ernst J Kuipers, Iris Lansdorp-Vogelaar, Marie-Louise Essink-Bot, Manon C W Spaander, Evelien Dekker
BACKGROUND: The effectiveness of faecal immunochemical test (FIT)-based screening programs is highly dependent on consistent participation over multiple rounds. We evaluated adherence to FIT screening over four rounds and aimed to identify determinants of participation behaviour. METHODS: A total of 23 339 randomly selected asymptomatic persons aged 50-74 years were invited for biennial FIT-based colorectal cancer screening between 2006 and 2014. All were invited for every consecutive round, except for those who had moved out of the area, passed the upper age limit, or had tested positive in a previous screening round...
December 6, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27922514/factors-associated-with-intestinal-constipation-in-chronic-patients-with-stroke-sequelae-undergoing-rehabilitation
#19
Tânia Mara Nascimento de Miranda Engler, Márcia Helena de Assis Aguiar, Íris Aline Brito Furtado, Samile Pereira Ribeiro, Pérola de Oliveira, Paulo Andrade Mello, Marcele Pescuma Capeletti Padula, Paulo Sérgio Siebra Beraldo
The objective of this study was to define which stroke-related factors constitute independent variables in the incidence of intestinal constipation (IC) of chronic patients admitted to a hospital rehabilitation program. All patients consecutively admitted for rehabilitation were recruited for the study. In the Poisson multiple regression analysis using a hierarchical model, sociodemographic variables, comorbidities, medication, previous history of constipation, life habits, and stroke-related variables were considered for defining factors associated with IC...
November 2016: Gastroenterology Nursing: the Official Journal of the Society of Gastroenterology Nurses and Associates
https://www.readbyqxmd.com/read/27922265/intergenerational-relationships-and-the-trajectory-of-depressive-symptoms-among-older-chinese-adults-in-rural-migrant-families
#20
Nan Lu, Ling Xu, Vivian W Q Lou, Iris Chi
OBJECTIVES: This study examined the trajectory patterns of depressive symptoms of older rural Chinese adults in migrant families and the role of intergenerational relationships in predicting trajectory class memberships. METHOD: Data were derived from the 2001, 2003, 2006, and 2009 waves of a longitudinal survey titled The Well-being of Older People in Anhui Province. The sample featured 486 respondents who had at least one migrant adult children at all four waves...
December 6, 2016: Aging & Mental Health
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