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https://www.readbyqxmd.com/read/29224017/the-il-2-anti-il-2-complex-attenuates-cardiac-ischaemia-reperfusion-injury-through-expansion-of-regulatory-t-cells
#1
Junhui Xiao, Kunwu Yu, Ming Li, Chuanyin Xiong, Yuzhen Wei, Qiutang Zeng
BACKGROUND/AIMS: Regulatory T cells (Tregs) can suppress immunologic damage in myocardial ischaemia/reperfusion injury (MIRI), however, the isolation and ex vivo expansion of these cells for clinical application remains challenging. Here, we investigated whether the IL-2/anti-IL-2 complex (IL-2C), a mediator of Treg expansion, can attenuate MIRI in mice. METHODS: Myocardial I/R was surgically induced in male C57BL/6 mice, aged 8-10 weeks, that were randomly assigned to 1) sham group (Sham), 2) Phosphate Buffered Saline (PBS), 3) IL-2-anti-IL-2 Ab complex (IL-2C), or 4) sham group, 5) PBS, 6) IL-2C after MIRI, or 7) IL-2C, 8) IL-2C+anti-CD25 mAbs, or 9) IL-2C; 10) IL-2C+anti-TGF-β1 mAbs, 11) IL-2C+anti-IL-10 mAbs...
December 7, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29223388/transplantation-in-the-treatment-of-primary-cutaneous-aggressive-epidermotropic-cytotoxic-cd8-positive-t-cell-lymphoma
#2
Benoit M Cyrenne, Juliet Fraser Gibson, Antonio Subtil, Michael Girardi, Iris Isufi, Stuart Seropian, Francine Foss
BACKGROUND: Primary cutaneous aggressive epidermotropic cytotoxic CD8 positive T-cell lymphoma (CD8+ PCAETL) is a rare subtype of peripheral T-cell lymphoma with poor outcomes and without a standardized treatment strategy. Allogeneic hematopoietic stem cell transplantation (HSCT) has been suggested as a potential curative therapy. PATIENTS AND METHODS: We conducted a retrospective case series. We identified 8 patients with the diagnosis of CD8+ PCAETL, 4 of whom also underwent allogeneic HSCT...
December 6, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29223242/decades-old-windshield-glass-perforating-injury-with-limbal-iris-incarceration-zonular-fiber-defect-and-equatorial-lens-capsule-injury-with-capsule-fibrosis-and-dense-cataract-november-consultation-1
#3
https://www.readbyqxmd.com/read/29223238/pupillary-block-glaucoma-secondary-to%C3%A2-central-port-occlusion-following-insertion-of-a-phakic-implantable-copolymer-lens
#4
Felix Gonzalez-Lopez, Rafael Bilbao-Calabuig, Ricardo Alen, Blas Mompean
A 28-year-old woman had uneventful implantation of a phakic intraocular lens (pIOL) in her left eye (Visian ICL, EVO+ model, 13.2, -7.50 diopters) to correct myopia. Six days after the procedure, she presented with herniation of the iris. Surgical reduction was carried out successfully through the previous peripheral corneal paracentesis. On the following day, the patient reported ocular pain and blurry vision. Examination showed a shallow anterior chamber, moderate diffuse corneal edema, and ocular hypertension...
November 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29223192/training-needs-for-dementia-care-in-china-from-the-perspectives-of-mental-health-providers-who-what-and-how
#5
Ling Xu, Hsin-Yi Hsiao, Wenchen Denq, Iris Chi
BACKGROUND: Acknowledging increasing demand of dementia care for patients in China, this paper aims to understand the training needs of dementia care from the perspectives of mental health providers by examining who should be the trainees, what should be the contents of training, and how to deliver the training in China. METHODS: Using purposive sampling, data were gathered via four focus group discussions with 40 mental health providers in Beijing, China, in 2011...
December 10, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29223019/are-pathological-high-risk-features-in-locally-advanced-rectal-cancer-a-useful-selection-tool-for-adjuvant-chemotherapy
#6
Marloes Swets, Peter J K Kuppen, Erik J Blok, Hans Gelderblom, Cornelis J H van de Velde, Iris D Nagtegaal
BACKGROUND: Several histological high-risk factors are used as an indication for adjuvant therapy in stage II colon cancer. Those and other factors, including lymphatic invasion, perineural invasion (PNI), venous invasion and tumour budding are associated with decreased outcome. In this study, we evaluated the prognostic and predictive values of these biomarkers in a cohort of rectal cancer patients. MATERIALS AND METHODS: The trial-based cohort consisted of 221npTNM stage II-III rectal cancer patients, included in the PROCTOR/SCRIPT trial, a multicentre randomised phase III trial...
December 6, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29222903/vitamin-d-status-and-cardiometabolic-risk-factors-in-young-adults-in-hong-kong-associations-and-implications
#7
Erica Wei-Lan Wang, Marco Yiu-Chung Pang, Parco Ming-Fai Siu, Claudia Kam-Yuk Lai, Jean Woo, Andrew R Collins, Iris Ff Benzie
BACKGROUND AND OBJECTIVES: Vitamin D deficiency is reportedly common, but we lack data from young adults. Such data are of interest because epidemiological data support vitamin D as a possible risk modulator for diabetes and cardiovascular ('cardiometabolic') disease. Our objectives were to assess vitamin D status (as plasma 25(OH)D concentration) and investigate associations between this and biomarkers of cardiometabolic disease risk in a group of still-healthy young adults in Hong Kong...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222092/targeted-disruption-of-the-kcnj5-gene-in-the-female-mouse-lowers-aldosterone-levels
#8
Iris Hardege, Lu Long, Raya Al Maskari, Nicola Figg, Kevin M O'Shaughnessy
Aldosterone is released from adrenal zona glomerulosa cells and plays an important role in Na and K homeostasis. Mutations in the human KCNJ5 gene encoding the GIRK4 potassium channel cause abnormal aldosterone secretion and hypertension. To better understand the role of wild-type (WT) GIRK4 in regulating aldosterone release we have looked at aldosterone secretion in a Kcnj5 knock-out (KO) mouse.  We found that female, but not male, KO mice have reduced aldosterone levels compared to WT female controls, but higher levels of aldosterone after Ang-II stimulation...
December 8, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29220066/periorbital-changes-associated-with-topical-prostaglandins-analogues-in-a-hispanic-population
#9
Ferdinand Rodríguez-Agramonte, Juan Carlos Jiménez, José Raúl Montes
OBJECTIVE: To describe the prevalent side effects of prostaglandin analogues (PA) in a Hispanic population and their effect on quality of life (QOL). PATIENTS AND METHODS: This is a cross-sectional study conducted in a tertiary medical facility in which patients were evaluated in a single visit. Total of 14 participants in the study, 10 women and 4 men. Ages ranged from 26-78 years old. Subjects underwent a single full Oculoplastic evaluation by two physicians; one was blinded on patient medical history and assessed for PA side effects...
December 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29219633/brain-activity-during-phonation-in-healthy-female-singers-with-supraglottic-compression-an-fmri-pilot-study
#10
Maryna Kryshtopava, Kristiane Van Lierde, Charlotte Defrancq, Michiel De Moor, Zoë Thijs, Evelien D'Haeseleer, Iris Meerschman, Pieter Vandemaele, Guy Vingerhoets, Sofie Claeys
This pilot study evaluated the usability of functional magnetic resonance imaging (fMRI) to detect brain activation during phonation in healthy female singers with supraglottic compression. Four healthy female classical singers (mean age: 26 years) participated in the study. All subjects had normal vocal folds and vocal characteristics and showed supraglottic compression. The fMRI experiment was carried out using a block design paradigm. Brain activation during phonation and exhalation was analyzed using Brain Voyager software (Brain Innovation B...
December 8, 2017: Logopedics, Phoniatrics, Vocology
https://www.readbyqxmd.com/read/29219604/phonon-sidebands-in-monolayer-transition-metal-dichalcogenides
#11
Dominik Christiansen, Malte Selig, Gunnar Berghäuser, Robert Schmidt, Iris Niehues, Robert Schneider, Ashish Arora, Steffen Michaelis de Vasconcellos, Rudolf Bratschitsch, Ermin Malic, Andreas Knorr
Excitons dominate the optical properties of monolayer transition metal dichalcogenides (TMDs). Besides optically accessible bright exciton states, TMDs exhibit also a multitude of optically forbidden dark excitons. Here, we show that efficient exciton-phonon scattering couples bright and dark states and gives rise to an asymmetric excitonic line shape. The observed asymmetry can be traced back to phonon-induced sidebands that are accompanied by a polaron redshift. We present a joint theory-experiment study investigating the microscopic origin of these sidebands in different TMD materials taking into account intra- and intervalley scattering channels opened by optical and acoustic phonons...
November 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29219455/universal-quantum-computation-with-gapped-boundaries
#12
Iris Cong, Meng Cheng, Zhenghan Wang
This Letter discusses topological quantum computation with gapped boundaries of two-dimensional topological phases. Systematic methods are presented to encode quantum information topologically using gapped boundaries, and to perform topologically protected operations on this encoding. In particular, we introduce a new and general computational primitive of topological charge measurement and present a symmetry-protected implementation of this primitive. Throughout the Letter, a concrete physical example, the Z_{3} toric code [D(Z_{3})], is discussed...
October 27, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29218832/necrotizing-enterocolitis-in-the-setting-of-milk-allergy-after-pediatric-living-donor-liver-transplantation
#13
Soichi Narumoto, Seisuke Sakamoto, Hajime Uchida, Kengo Sasaki, Takanobu Shigeta, Akinari Fukuda, Shunsuke Nosaka, Rie Irie, Takako Yoshioka, Mureo Kasahara
NEC is an idiopathic intestinal mucosal injury that may progress to transmural bowel necrosis without mesenteric ischemia. NEC usually affects 7- to 10-day-old neonates following enteral feeding. A 10-month-old girl with no history of laparotomy underwent LDLT for acute liver failure. After starting enteral feeding on postoperative day 5, she developed abdominal distention. Diffuse PVG and PI were detected by radiologic modalities. Exploratory laparotomy revealed patchy necrosis of the intestine without perforation...
December 7, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29218653/differential-diagnosis-of-pancreatic-epidermoid-cyst-without-a-solid-component-residual-splenic-tissue-vs-mucinous-cystic-neoplasm
#14
Kousei Ishigami, Akihiro Nishie, Hiroyuki Irie, Yoshiki Asayama, Yasuhiro Ushijima, Yukihisa Takayama, Daisule Okamoto, Nobuhiro Fujita, Takao Ohtsuka, Tetsuhide Ito, Naoki Mochidome, Hiroshi Honda
PURPOSE: The purpose of this study was to clarify whether there are differences in imaging findings between pancreatic epidermoid cyst (EDC) without a solid component (residual splenic tissue) and mucinous cystic neoplasm (MCN). MATERIALS AND METHODS: The study group consisted of histologically proven EDC (eight cases) and MCN (20 cases). CT and MRI findings were compared on the following imaging findings: the shape of the cystic lesions and the presence or absence of septum, calcification, and high-intensity fluid on T1- and diffusion-weighted images (b factor = 1000)...
December 7, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29218468/prediction-of-unfavorable-outcomes-in-cryptococcal-meningitis-results-of-the-multicenter-infectious-diseases-international-research-initiative-id-iri-cryptococcal-meningitis-study
#15
I N Hakyemez, H Erdem, G Beraud, M Lurdes, A Silva-Pinto, C Alexandru, B Bishop, F Mangani, X Argemi, M Poinot, R Hasbun, M Akcaer, S Alp, T Demirdal, K Angamuthu, F Amer, E Ragab, G A Shehata, D Ozturk-Engin, N Ozgunes, L Larsen, S Zimmerli, O R Sipahi, E Tukenmez Tigen, G Celebi, N Oztoprak, A C Yardimci, Y Cag
Cryptococcal meningitis (CM) is mostly seen in immunocompromised patients, particularly human immunodeficiency virus (HIV)-positive patients, but CM may also occur in apparently immunocompetent individuals. Outcome analyses have been performed in such patients but, due to the high prevalence of HIV infection worldwide, CM patients today may be admitted to hospitals with unknown HIV status, particularly in underdeveloped countries. The objective of this multicenter study was to analyze all types of CM cases in an aggregate cohort to disclose unfavorable outcomes...
December 8, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29217452/specific-agreement-on-ordinal-and-multiple-nominal-outcomes-can-be-calculated-for-more-than-two-raters
#16
Henrica C W de Vet, Margriet G Mullender, Iris Eekhout
OBJECTIVE: The concept of specific agreement has been proposed for dichotomous outcomes for two and more raters. We aim to extend this concept for variables with more than two ordinal or nominal categories and more than two raters. STUDY DESIGN AND SETTING: We used two data sets: 4 plastic surgeons classifying photographs after breast reconstruction on a 5 point ordinal scale; and 6 raters classifying psychiatric patients into 5 diagnostic categories. For m raters, all (i...
December 4, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29217025/correlation-of-novel-pax6-gene-abnormalities-in-aniridia-and-clinical-presentation
#17
Naif S Sannan, Cheryl Y Gregory-Evans, Christopher J Lyons, Anna M Lehman, Sylvie Langlois, Simon J Warner, Helen Zakrzewski, Kevin Gregory-Evans
OBJECTIVE: To describe the clinical presentation and genotype of subjects with aniridia with a particular focus on foveal hypoplasia. DESIGN: Prospective cohort study. PARTICIPANTS: Thirty-three Canadian participants with aniridia and of various ethnic backgrounds residing in British Columbia. METHODS: Full ophthalmic examinations and posterior segment spectral domain-optical coherence tomography (SD-OCT) imaging were performed...
December 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29216585/determination-of-irinotecan-and-its-metabolite-sn-38-in-dried-blood-spots-using-high-performance-liquid-chromatography-with-fluorescence-detection
#18
Roberta Z Hahn, Priscila C Arnhold, Natália B Andriguetti, Anelise Schneider, Helena M Klück, Simone L Dos Reis, Marcos Frank Bastiani, Igor Kael, Anne Caroline Cezimbra da Silva, Gilberto Schwartsmann, Marina V Antunes, Rafael Linden
Irinotecan (IRI) is an antineoplastic drug widely used for the treatment of colorectal and advanced pancreatic cancer. Despite its clinical utility, the clinical use of IRI is associated with potentially severe hematopoietic and gastrointestinal toxicities. The quantification of IRI and its active metabolite SN-38 in dried blood spots (DBS) may be an alternative to individualize the drug dose through a minimally invasive and easy collection method. The aim of this study was to develop and validate a simple and fast HPLC-FL assay for simultaneous IRI and SN-38 measurement in DBS, with adequate analytical performance for clinical use...
December 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29215951/regulation-of-aqueous-humor-dynamics-by-hydrogen-sulfide-potential-role-in-glaucoma-pharmacotherapy
#19
Sunny E Ohia, Jenaye Robinson, Leah Mitchell, Kalu K Ngele, Segewkal Heruye, Catherine A Opere, Ya Fatou Njie-Mbye
Hydrogen sulfide (H2S) is a gaseous transmitter with well-known biological actions in a wide variety of tissues and organs. The potential involvement of this gas in physiological and pathological processes in the eye has led to several in vitro, ex vivo, and in vivo studies to understand its pharmacological role in some mammalian species. Evidence from literature demonstrates that 4 enzymes responsible for the biosynthesis of this gas (cystathionine β-synthase, CBS; cystathionine γ-lyase, CSE; 3-mercaptopyruvate sulfurtransferase, 3MST; and d-amino acid oxidase) are present in the cornea, iris, ciliary body, lens, and retina...
December 7, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29214112/hypomelanotic-melanoma-detected-by-the-little-red-riding-hood-sign-in-a-patient-with-neurofibromatosis-type-1
#20
Roberta Giuffrida, Maximilian Uranitsch, Karin Schmid, Teresa Deinlein, Fabrizio Favero, Iris Zalaudek
Neurofibromatosis type 1 (NF1) is a genetic disorder commonly associated with an increased risk for development of malignancy, including skin cancers. Herein we describe a case of invasive melanoma occurring in a patient with NF1 and discuss the association between these two diseases, highlighting the importance of comparative clinical and dermoscopic approaches in this category of patients in which the detection of melanoma can be difficult because of the presence of multiple skin tumors.
October 2017: Dermatology Practical & Conceptual
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