Tuvshintugs Baljinnyam, Yosuke Niimi, John R Salsbury, Satoshi Fukuda, Casey M Ouellette, Clark R Andersen, Yasutaka Hirasawa, Donald A Prough, C Edwin Garner, Andrew L Salzman, Perenlei Enkhbaatar
Characterization of the pathophysiology of ARDS following chlorine gas inhalation in clinically relevant translational large animal models is essential, as the opportunity for clinical trials in this type of trauma is extremely limited. To investigate Cl2 concentration and gender-dependent ARDS severity. Sheep (n = 54) were exposed to air or Cl2 premixed in air at a concentration of 50, 100, 200, and 300 ppm for 30 min under anesthesia/analgesia and monitored for an additional 48 h in a conscious state...
December 15, 2023: Scientific Reports