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Childhood leukemia

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https://www.readbyqxmd.com/read/28802664/cytokines-and-soluble-hla-g-levels-in-bone-marrow-stroma-and-their-association-with-the-survival-rate-of-patients-exhibiting-childhood-t-cell-acute-lymphoblastic-leukemia
#1
Renata Dos Santos Almeida, Alessandra Maria de Luna Ramos, Carlos Feitosa Luna, Francisco Pedrosa, Eduardo Antônio Donadi, Norma Lucena-Silva
Leukemic cells can induce defective expression of soluble factors and change marrow cytokine profile, leading to aberrant cell signaling, cell fixation and cell proliferation in bone marrow. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disorder which accounts for 15% of pediatric ALL. To evaluate the contribution of immunological factors on T-ALL survival, we measured Th1, Th2, Th17 cytokines and soluble HLA-G (sHLA-G) levels in bone marrow from 32 Brazilian children at diagnosis (D0), after induction (D19) and after consolidation (D49) of the chemotherapy phase...
August 9, 2017: Cytokine
https://www.readbyqxmd.com/read/28794069/phase-i-study-of-the-anti-cd22-immunotoxin-moxetumomab-pasudotox-for-childhood-acute-lymphoblastic-leukemia
#2
Alan S Wayne, Nirali N Shah, Deepa Bhojwani, Lewis B Silverman, James A Whitlock, Maryalice Stetler-Stevenson, Weili Sun, Meina Liang, Jie Yang, Robert J Kreitman, Mark C Lanasa, Ira Pastan
Novel therapies are needed to overcome chemotherapy resistance for children with relapsed/refractory acute lymphoblastic leukemia (ALL). Moxetumomab pasudotox is a recombinant anti-CD22 immunotoxin. A multicenter, phase I study was conducted to determine the maximum tolerated cumulative dose (MTCD) and evaluate safety, activity, pharmacokinetics, and immunogenicity of moxetumomab pasudotox in children, adolescents, and young adults with ALL (n=55). Moxetumomab pasudotox was administered as a 30-minute intravenous infusion at doses of 5 to 50 µg/kg every other day (QOD) for six (Cohorts A and B) or 10 (Cohort C) doses, on 21-day cycles...
August 9, 2017: Blood
https://www.readbyqxmd.com/read/28792268/kit-mutations-correlate-with-adverse-survival-in-children-with-core-binding-factor-acute-myeloid-leukemia
#3
Xi Chen, Hu Dou, Xingjuan Wang, Yi Huang, Ling Lu, Junqing Bin, Yongchun Su, Lin Zou, Jie Yu, Liming Bao
The prevalence and clinical relevance of KIT mutations in childhood core-binding factor (CBF) acute myeloid leukemia (AML) have not been well characterized. In this study, a total of 212 children with de novo AML were enrolled from a Chinese population and 50 (23.5%) of the patients were deemed CBF-AML. KIT mutations were identified in 30% of the CBF-AML cohort. The KIT mutations were clustered in exon 17 and exon 8, and KIT mutations in exons 8 and 17 were correlated with a shorter overall survival (OS) (5-year OS: 30...
August 9, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28783412/am-i-a-6-or-a-10-mate-value-among-young-adult-survivors-of-childhood-cancer-and-healthy-peers
#4
Vicky Lehmann, Marrit A Tuinman, Madelaine C Keim, Mariët Hagedoorn, Cynthia A Gerhardt
PURPOSE: This study focused on self-perceived mate value of young adult survivors of childhood cancer relative to healthy peers. Qualitative studies indicate potential problems surrounding romantic relationships among survivors, but systematic studies are missing. METHODS: One-hundred forty-nine childhood cancer survivors and 149 matched controls completed online questionnaires about their mate value, social comparison strategies (i.e., upward/downward identifying/contrasting strategies), and marital status...
August 7, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28775249/therapeutic-radiation-for-childhood-cancer-drives-structural-aberrations-of-nf2-in-meningiomas
#5
Sameer Agnihotri, Suganth Suppiah, Peter D Tonge, Shahrzad Jalali, Arnavaz Danesh, Jeffery P Bruce, Yasin Mamatjan, George Klironomos, Lior Gonen, Karolyn Au, Sheila Mansouri, Sharin Karimi, Felix Sahm, Andreas von Deimling, Michael D Taylor, Normand J Laperriere, Trevor J Pugh, Kenneth D Aldape, Gelareh Zadeh
Cranial radiotherapy improves survival of the most common childhood cancers, including brain tumors and leukemia. Unfortunately, long-term survivors are faced with consequences of secondary neoplasia, including radiation-induced meningiomas (RIMs). We characterized 31 RIMs with exome/NF2 intronic sequencing, RNA sequencing and methylation profiling, and found NF2 gene rearrangements in 12/31 of RIMs, an observation previously unreported in sporadic meningioma (SM). Additionally, known recurrent mutations characteristic of SM, including AKT1, KLF4, TRAF7 and SMO, were not observed in RIMs...
August 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/28774373/-association-between-bim-gene-and-glucocorticoid-resistance-in-children-with-acute-lymphoblastic-leukemia
#6
Jin-Yun Xu, Jian-Ming Luo
Acute lymphoblastic leukemia (ALL) is the most common malignant hematological disease in childhood. Glucocorticoids are frequently used in the chemoradiotherapy regimen for ALL and can induce the apoptosis of ALL cells through several signaling pathways, but about 10% of ALL children have poor response to glucocorticoids. Studies have revealed that glucocorticoids induce the apoptosis of ALL cells by upregulating the expression of BIM gene, and BIM gene is associated with glucocorticoid resistance in childhood ALL...
August 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28770363/residential-exposure-to-ultraviolet-light-and-risk-of-precursor-b-cell-acute-lymphoblastic-leukemia-assessing-the-role-of-individual-risk-factors-the-escale-and-estelle-studies
#7
Astrid Coste, Denis Hémon, Laurent Orsi, Mathieu Boniol, Jean-François Doré, Laure Faure, Jacqueline Clavel, Stéphanie Goujon
BACKGROUND: In a previous nationwide ecological study based on 20 years of registration and 7,443 cases of acute lymphoblastic leukemia (ALL), we reported a positive association between residential solar ultraviolet (UV) light at diagnosis and childhood precursor B-cell acute lymphoblastic leukemia (PBC-ALL). OBJECTIVE: The present study investigated the influence of suspected individual risk factors for ALL on the association between UV and PBC-ALL, and evaluated this association at the residence at birth...
August 2, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28767575/dnmt3a-mutations-in-chinese-childhood-acute-myeloid-leukemia
#8
Weijing Li, Lei Cui, Chao Gao, Shuguang Liu, Xiaoxi Zhao, Ruidong Zhang, Huyong Zheng, Minyuan Wu, Zhigang Li
BACKGROUND: DNA methyltransferase 3A (DNMT3A) mutations have been found in approximately 20% of adult acute myeloid leukemia (AML) patients and in 0% to 1.4% of children with AML, and the hotspots of mutations are mainly located in the catalytic methyltransferase domain, hereinto, mutation R882 accounts for 60%. Although the negative effect of DNMT3A on treatment outcome is well known, the prognostic significance of other DNMT3A mutations in AML is still unclear. Here, we tried to determine the incidence and prognostic significance of DNMT3A mutations in a large cohort in Chinese childhood AML...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28766887/a-cost-analysis-of-individualized-asparaginase-treatment-in-pediatric-acute-lymphoblastic-leukemia
#9
Robin Q H Kloos, Carin A Uyl-de Groot, Raphaële R L van Litsenburg, Gertjan J L Kaspers, Rob Pieters, Inge M van der Sluis
BACKGROUND: Therapeutic drug monitoring (TDM) of asparaginase is necessary to respond to variability in asparaginase activity levels, detect silent inactivation, and distinguish between real allergies and allergic-like reactions with and without asparaginase neutralization, respectively. In this study, the costs of an individualized and fixed asparaginase dosing schedule were compared. PROCEDURE: Patients, treated according to the Dutch Childhood Oncology Group ALL-11 protocol (individualized PEGasparaginase treatment, starting dose: 1,500 IU/m(2) ) or ALL-10 protocol (native Escherichia coli asparaginase followed by 2,500 IU/m(2) PEGasparaginase), were included...
August 2, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28766851/folate-deficiency-in-north-indian-children-undergoing-maintenance-chemotherapy-for-acute-lymphoblastic-leukemia-implications-and-outcome
#10
Nirmalya Roy Moulik, Archana Kumar, Suraksha Agrawal, Abbas Ali Mahdi
BACKGROUND: Treatment-related toxicity and mortality are not uncommon during maintenance chemotherapy for childhood acute lymphoblastic leukemia (ALL), especially in the low- and middle-income countries (LMIC). Undernutrition and micronutrient deficiencies are commonly seen in children from LMICs undergoing treatment for ALL. The present study examines the prevalence and clinical implications of folate deficiency in north Indian children with ALL during the maintenance phase of treatment in view of prolonged antifolate treatment and high population prevalence of folate deficiency...
August 2, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28766841/value-of-flow-cytometric-analysis-of-peripheral-blood-samples-in-children-diagnosed-with-acute-lymphoblastic-leukemia
#11
Grace Lam, Angela Punnett, Derek Stephens, Lillian Sung, Mohamed Abdelhaleem, Johann Hitzler
Diagnostic procedures in children with acute lymphoblastic leukemia (ALL) are typically performed under general anesthesia. Anticipation of the diagnosis based on findings in peripheral blood allows scheduling of the first dose of intrathecal chemotherapy and diagnostic bone marrow (BM) aspirate during a single anesthetic. We retrospectively compared paired results of peripheral blood (PB) flow cytometric analysis and BM evaluation in 383 children with ALL diagnosed consecutively at a single center and found very high concordance of results between both tests...
August 2, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28761277/bilateral-parotidomegaly-as-an-initial-manifestation-of-acute-lymphoblastic-leukemia-in-a-child-a-case-report-and-review-of-literature
#12
Latha Magatha Sneha, Kaarthikeyani Sankaravadivelu Subbiah, Julius Xavier Scott, Aruna Rajendiran
The more common causes of parotid enlargement in children are infections and inflammatory conditions. Primary neoplasms of the parotid glands are rare in pediatric age group; however, secondary malignancies have been reported in survivors of childhood leukemia. The parotid glands have been the sites of relapses in acute lymphoblastic leukemia (ALL) and acute myeloid leukemia. However, bilateral parotid involvement as an initial presentation of ALL is rarely reported. We present a case of an 8-year-old boy who presented with bilateral parotid enlargement as an initial manifestation of ALL...
January 2017: National Journal of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28755627/the-importance-of-laboratory-re-evaluation-in-cases-of-suspected-child-abuse-a-case-report
#13
L Woydt, C König, M K Bernhard, P Nickel, J Dreßler, B Ondruschka
In order to accurately diagnose child abuse or neglect, a physician needs to be familiar with diseases and medical conditions that can simulate maltreatment. Unrecognized cases of abuse may lead to insufficient child protection, whereas, on the other hand, over-diagnosis could be the cause of various problems for the family and their potentially accused members. Regarding child abuse, numerous cases of false diagnoses with undetected causes of bleeding are described in the scientific literature, but, specifically concerning leukemia in childhood, only very few case reports exist...
July 24, 2017: Legal Medicine
https://www.readbyqxmd.com/read/28751566/prolonged-versus-standard-native-e-coli-asparaginase-therapy-in-childhood-acute-lymphoblastic-leukemia-and-non-hodgkin-lymphoma-final-results-of-the-eortc-clg-randomized-phase-iii-trial-58951
#14
Veerle Mondelaers, Stefan Suciu, Barbara De Moerloose, Alina Ferster, Françoise Mazingue, Geneviève Plat, Karima Yakouben, Anne Uyttebroeck, Patrick Lutz, Vitor Costa, Nicolas Sirvent, Emmanuel Plouvier, Martine Munzer, Maryline Poirée, Odile Minckes, Frédéric Millot, Dominique Plantaz, Philip Maes, Claire Hoyoux, Hélène Cave', Pierre Rohrlich, Yves Bertrand, Yves Benoit
Asparaginase is an essential component of combination chemotherapy for childhood acute lymphoblastic leukemia and non-Hodgkin's lymphoma. The value of asparaginase was further addressed in a group of non-very high risk patients by comparing a prolonged (long-asparaginase) versus standard (short-asparaginase) native E.coli asparaginase treatment through a randomized question as part of the phase III 58951 trial of the European Organisation for Research and Treatment of Cancer Children's Leukemia Group. The main endpoint was disease-free survival...
July 27, 2017: Haematologica
https://www.readbyqxmd.com/read/28751478/-span-style-font-weight-400-novel-gene-and-network-associations-found-for-span-span-style-font-weight-400-a-span-span-style-font-weight-400-cute-span-span-style-font-weight-400-l-span-span-style-font-weight-400-ymphoblastic-span-span-style-font-weight-400-l
#15
Priyanka Nakka, Natalie P Archer, Heng Xu, Philip J Lupo, Benjamin J Raphael, Jun J Yang, Sohini Ramachandran
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, suggesting that germline variants influence ALL risk. Although multiple genome-wide association (GWA) studies have identified variants predisposing children to ALL, it remains unclear whether genetic heterogeneity affects ALL susceptibility and how interactions within and among genes containing ALL-associated variants influence ALL risk. METHODS: Here we jointly analyze two published datasets of case-control GWA summary statistics along with germline data from ALL case-parent trios...
July 27, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28742520/growth-and-pubertal-patterns-in-young-survivors-of-childhood-acute-lymphoblastic-leukemia
#16
Sarah Elitzur, Revital Houri-Shtrecher, Michal Yackobovitz-Gavan, Galia Avrahami, Shlomit Barzilai, Gil Gilad, Yael Lebenthal, Moshe Phillip, Batia Stark, Isaac Yaniv, Shlomit Shalitin
BACKGROUND: Survivors of acute lymphoblastic leukemia (ALL) may experience endocrine dysfunction. This study evaluated growth and pubertal patterns in survivors of childhood ALL. METHODS: Longitudinal assessment of anthropometric measurements and pubertal status was performed in a retrospective cohort of survivors (n=183). Median age at last endocrine visit was 16.1 years (range 8.2-27.6); median follow-up time was 8.7 years (range 3-21.4). RESULTS: Treatment with chemotherapy+prophylactic cranial radiation (pCRT, n=29) was associated with lower mean height standard deviation score (SDS) than chemotherapy alone (n=154) (p=0...
August 28, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28742150/cancer-incidence-rates-and-trends-among-children-and-adolescents-in-piedmont-1967-2011
#17
Elena Isaevska, Milena Manasievska, Daniela Alessi, Maria Luisa Mosso, Corrado Magnani, Carlotta Sacerdote, Guido Pastore, Franca Fagioli, Franco Merletti, Milena Maule
In the past, increases in childhood cancer incidence were reported in Europe and North America. The aim of this study is to show updated patterns of temporal behavior using data of the Childhood Cancer Registry of Piedmont (CCRP), a region with approximately 4.5 million inhabitants in North-West Italy. CCRP has been recording incident cases in children (0-14 years) since 1967 and in adolescents (15-19) since 2000. Time trends were estimated as annual percent change (APC) over the 1976-2011 period for children, and over 2000-2011 for both children and adolescents...
2017: PloS One
https://www.readbyqxmd.com/read/28741305/erratum-nguyen-r-jeha-s-zhou-y-et%C3%A2-al-the-role-of-leukapheresis-in-the-current-management-of-hyperleukocytosis-in-newly-diagnosed-childhood-acute-lymphoblastic-leukemia-pediatr-blood-cancer-2016-63-1546-1551-https-doi-org-10-1002-pbc-26056
#18
https://www.readbyqxmd.com/read/28740405/novel-agents-for-the-treatment-of-childhood-leukemia-an-update
#19
REVIEW
Ertugrul Eryılmaz, Cengiz Canpolat
Achieving lower morbidity and higher survival rates in the treatment of childhood leukemia has been a paradigm of success in modern oncology. However, serious long-term health complications occur in very large populations of childhood leukemia survivors, in the case of both acute lymphoid leukemia and acute myeloid leukemia (AML). Additionally, 15% of acute lymphoid leukemia patients have treatment failures, and rates are even higher in childhood AML. In the last few decades, as a result of well-tested experiments that statistically analyzed treatment cohorts, new agents have emerged as alternatives or supplements to established treatments, in which high survival and/or less morbidity were observed...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28738185/mother-and-child-characteristics-at-birth-and-early-age-leukemia-a-case-cohort-population-based-study-in-brazil
#20
Rejane de Souza Reis, Neimar de Paula Silva, Marceli de Oliveira Santos, Julio Fernando Pinto Oliveira, Luiz Claudio Santos Thuler, Beatriz de Camargo, Maria S Pombo-de-Oliveira
OBJECTIVE: The population-based cancer registries (PBCR) and the Information System on Live Births in Brazil (Sistema de Informações sobre Nascidos Vivos [SINASC]) have information that enables the test for risk factors associated with leukemia at an early age. The aim of this study was to identify maternal and birth characteristics associated with early-age acute leukemia (EAL) in Brazil. METHODS: A case-cohort study was performed using secondary dataset information of PBCR and SINASC...
July 21, 2017: Jornal de Pediatria
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