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https://www.readbyqxmd.com/read/28072841/a-small-insulinomimetic-molecule-also-improves-insulin-sensitivity-in-diabetic-mice
#1
Sandip Mukherjee, Mrittika Chattopadhyay, Sushmita Bhattacharya, Suman Dasgupta, Sahid Hussain, Saitanya K Bharadwaj, Dhrubajyoti Talukdar, Abul Usmani, Bhola S Pradhan, Subeer S Majumdar, Pronobesh Chattopadhyay, Satinath Mukhopadhyay, Tushar K Maity, Mihir K Chaudhuri, Samir Bhattacharya
Dramatic increase of diabetes over the globe is in tandem with the increase in insulin requirement. This is because destruction and dysfunction of pancreatic β-cells are of common occurrence in both Type1 diabetes and Type2 diabetes, and insulin injection becomes a compulsion. Because of several problems associated with insulin injection, orally active insulin mimetic compounds would be ideal substitute. Here we report a small molecule, a peroxyvanadate compound i.e. DmpzH[VO(O2)2(dmpz)], henceforth referred as dmp, which specifically binds to insulin receptor with considerable affinity (KD-1...
2017: PloS One
https://www.readbyqxmd.com/read/28068060/structural-and-functional-basis-of-c-methylation-of-coumarin-scaffolds-by-novo
#2
Joanna C Sadler, Chun-Wa Chung, Julie E Mosley, Glenn A Burley, Luke D Humphreys
C-methylation of aromatic small molecules by C-methyltransferases (C-MTs) is an important biological trans-formation that involves C-C bond formation using S-adenosyl-L-methionine (SAM) as the methyl donor. Here, two advanc-es in the mechanistic understanding of C-methylation of the 8-position of coumarin substrates catalyzed by the C-MT No-vO from Streptomyces Spheroides are described. First, a crystal structure of NovO reveals the Arg116-Asn117 and His120-Arg121 motifs are essential for coumarin substrate binding...
January 9, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28067871/tumor-regression-concomitant-with-steroid-refractory-gvhd-highlights-the-pitfalls-of-pd-1-blockade-following-allogeneic-hematopoietic-stem-cell-transplantation
#3
E McDuffee, G Aue, L Cook, C Ramos-Delgado, R Shalabi, T Worthy, P Vo, R W Childs
No abstract text is available yet for this article.
January 9, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28063895/improvement-of-table-tennis-dystonia-by-stereotactic-ventro-oral-thalamotomy-a-case-report
#4
Takashi Asahi, Takaomi Taira, Kiyonobu Ikeda, Jiro Yamamoto, Shuji Sato
BACKGROUND: Task-specific focal dystonia, such as writer's cramp and musician's cramp, is a type of dystonia that affects performance of particular tasks. Such movement disorders have been treated with stereotactic ventro-oral (Vo) thalamotomy, with excellent outcomes. However, there has been no previous report of treatment of sport-related/athlete's dystonia by means of stereotactic surgery. We treated a patient with table tennis-related dystonia with Vo thalamotomy, and evaluated the outcome...
January 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28063717/half-life-of-plasma-phytosterols-in-very-low-birth-weight-preterm-infants-on-routine-parenteral-nutrition-with-vegetable-oil-based-lipid-emulsions
#5
Daniele Pupillo, Alessio Correani, Chiara Biagetti, Rita D'Ascenzo, Manuela Simonato, Giovanna Verlato, Paola Cogo, Marco B L Rocchi, Virgilio P Carnielli
BACKGROUND: Phytosterols in vegetable oil (VO)-based lipid emulsions (LE) likely contribute to parenteral nutrition-associated cholestasis (PNAC) in preterm infants. No characterization of plasma phytosterol half-lives has been done in very low birth weight (VLBW) preterm infants receiving parenteral nutrition (PN) with LE. METHODS: In a prospective cohort study, 45 VLBW preterm infants who received PN underwent serial blood sample measurements of sitosterol (SITO), campesterol (CAMP), and stigmasterol (STIGM)...
December 30, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28063437/strain-induced-friction-anisotropy-between-graphene-and-molecular-liquids
#6
Meng Liao, Quy-Dong To, Céline Léonard, Vincent Monchiet, Van-Hoang Vo
In this paper, we study the friction behavior of molecular liquids with anisotropically strained graphene. Due to the changes of lattice and the potential energy surface, the friction is orientation dependent and can be computed by tensorial Green-Kubo formula. Simple quantitative estimations are also proposed for the zero-time response and agree reasonably well with the molecular dynamics results. From simulations, we can obtain the information of structures, dynamics of the system, and study the influence of strain and molecular shapes on the anisotropy degree...
January 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28060191/palla-sign-in-acute-pulmonary-embolism
#7
Daniel Seung-Hun Lee, Hoang-Anh Vo, Arie Franco, Jayanth Keshavamurthy, Eran Rotem
No abstract text is available yet for this article.
January 2, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28059538/amplitude-modulated-bursting-a-novel-class-of-bursting-rhythms
#8
Theodore Vo, Mark A Kramer, Tasso J Kaper
We report on the discovery of a novel class of bursting rhythms, called amplitude-modulated bursting (AMB), in a model for intracellular calcium dynamics. We find that these rhythms are robust and exist on open parameter sets. We develop a new mathematical framework with broad applicability to detect, classify, and rigorously analyze AMB. Here we illustrate this framework in the context of AMB in a model of intracellular calcium dynamics. In the process, we discover a novel family of singularities, called toral folded singularities, which are the organizing centers for the amplitude modulation and exist generically in slow-fast systems with two or more slow variables...
December 23, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/28056502/environmental-occurrence-of-perfluoroalkyl-acids-and-novel-fluorotelomer-surfactants-in-the-freshwater-fish-catostomus-commersonii-and-sediments-following-firefighting-foam-deployment-at-the-lac-m%C3%A3-gantic-railway-accident
#9
Gabriel Munoz, Mélanie Desrosiers, Sung Vo Duy, Pierre Labadie, Helene Budzinski, Jinxia Liu, Sébastien Sauvé
: On July 6(th) 2013, an unmanned train laden with almost 8 million liters of crude oil careened off the rails downtown Lac-Mégantic (Québec, Canada). In the aftermath of the derailment accident, the emergency response entailed the deployment of 33,000 L of aqueous film forming foam (AFFF) concentrate that contained proprietary fluorosurfactants. The present study examines the environmental occurrence of perfluoroalkyl acids (PFAAs) and newly-identified per and polyfluoroalkyl substances (PFASs) in the benthic fish white sucker (Catostomus commersonii) and sediments from Lake Mégantic and Chaudière River...
January 6, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28052581/coupling-reactions-of-carbon-dioxide-with-epoxides-catalyzed-by-vanadium-aminophenolate-complexes
#10
Francesca Maria Kerton, Ali Issa Elkurtehi
A series of vanadium compounds supported by tetradentate amino-bis(phenolate) ligands were screened for catalytic reactivity in the reaction of propylene oxide (PO) with carbon dioxide, [VO(OMe)(O2NOBuMeMeth)] (1), [VO(OMe)(ON2OBuMe)] (2), [VO(OMe)(O2NNBuBuPy)] (3), and [VO(OMe)(O2NOBuBuFurf)] (4) (where (O2NOBuMeMeth) = MeOCH2CH2N(CH2ArO-)2, Ar = 3,5-C6H2-Me, tBu]; (ON2OBuMe) = -OArCH2NMeCH2 CH2NMeCH2ArO-, Ar = 3,5-C6H2-Me, tBu; (O2NNBuBuPy) = C5H4NCH2N(CH2ArO-)2, Ar = 3,5-C6H2-tBu2; (O2NOBuBuFurf) = C4H3OCH2N(CH2ArO-)2, Ar = 3,5-C6H2-tBu2)...
January 3, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28049261/nutrition-assessment-and-its-relationship-with-performance-and-glasgow-prognostic-scores-in-vietnamese-patients-with-esophageal-cancer
#11
Tran Chau Quyen, Jongjit Angkatavanich, Tran Van Thuan, Vo Van Xuan, Le Danh Tuyen, Do Anh Tu
BACKGROUND AND OBJECTIVES: To determine the nutritional status of patients with esophageal cancer, and to investigate its relationship with performance status and prognosis. METHODS AND STUDY DESIGN: This clinical, cross-sectional study was conducted from August 2014 to February 2015 at National Cancer Hospital, Hanoi, Vietnam. Stage III/IV esophageal cancer patients were assessed for their nutritional status (patient-generated subjective global assessment (PG-SGA) and SGA scores, BMI, mid-arm circumference (MAC), energy and protein intakes, weight changes, Karnofsky and Eastern cooperative oncology group performance scores (KPS/ECOG), and Glasgow prognostic score (GPS)...
January 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28048092/su-g-iep1-10-permeability-evaluation-of-interstitial-cystitis-by-dce-mri-of-the-bladder
#12
D Wu, J Vo, J North, R Towner, R Hurst
PURPOSE: Interstitial cystitis (IC) is a chronic and painful condition that can lead to bladder pain syndrome (BPS) in women. IC and BPS have been known to manifest after physiological changes after giving birth. In this project, we pioneered and advanced a new clinical utility using DCE-MRI to assess bladder permeability. At first IC/BPS perfusion methods were with ratio signal evaluation, we now incorporate pharmacokinetics techniques to allow for further assessment. METHODS: In this pilot study, female patients and volunteers (IC=4, Control=3) underwent imaging with a clinical GE 3T 750W MRI system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045000/geometric-constraints-on-phase-coexistence-in-vanadium-dioxide-single-crystals
#13
Christina L McGahan, Sampath Gamage, Jiran Liang, Brendan Cross, Robert Marvel, Richard Haglund, Yohannes Abate
The appearance of stripe phases is a characteristic signature of strongly correlated quantum materials, and its origin in phase-changing materials has only recently been recognized as the result of the delicate balance between atomic and mesoscopic materials properties. A vanadium dioxide (VO<sub>2</sub>) single crystal is one such strongly correlated material with stripe phases. Infrared nano-imaging on low-aspect-ratio, single-crystal VO<sub>2</sub> microbeams decorated with resonant plasmonic nanoantennas reveals a novel herringbone pattern of coexisting metallic and insulating domains intercepted and altered by ferroelastic domains, unlike previous reports on high-aspect-ratio VO<sub>2</sub> crystals where the coexisting metal/insulator domains appear as alternating stripe phases perpendicular to the growth axis...
January 3, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28041678/update-on-the-use-of-immunoglobulin-in-human-disease-a%C3%A2-review-of-evidence
#14
Elena E Perez, Jordan S Orange, Francisco Bonilla, Javier Chinen, Ivan K Chinn, Morna Dorsey, Yehia El-Gamal, Terry O Harville, Elham Hossny, Bruce Mazer, Robert Nelson, Elizabeth Secord, Stanley C Jordan, E Richard Stiehm, Ashley A Vo, Mark Ballow
Human immunoglobulin preparations for intravenous or subcutaneous administration are the cornerstone of treatment in patients with primary immunodeficiency diseases affecting the humoral immune system. Intravenous preparations have a number of important uses in the treatment of other diseases in humans as well, some for which acceptable treatment alternatives do not exist. We provide an update of the evidence-based guideline on immunoglobulin therapy, last published in 2006. Given the potential risks and inherent scarcity of human immunoglobulin, careful consideration of its indications and administration is warranted...
December 24, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28040602/investigation-of-cosmic-ray-induced-background-of-germanium-gamma-spectrometer-using-geant4-simulation
#15
Nguyen Quoc Hung, Vo Hong Hai, Masaharu Nomachi
In this article, a GEANT4 Monte Carlo simulation toolkit was used to study the response of the cosmic-ray induced background on a High-Purity Germanium (HPGe) gamma spectrometer in the wide energy range, up to 100MeV. The natural radiation background measurements of the spectrometer were carried out in the energy region from 0.04 to 50MeV. The simulated cosmic-ray induced background of the Ge detector was evaluated in comparison with the measured data. The contribution of various cosmic-ray components including muons, neutrons, protons, electrons, positrons and photons was investigated...
December 28, 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28039859/cholesterol-crystallisation-in-human-atherosclerosis-is-triggered-in-smooth-muscle-cells-during-the-transition-from-fatty-streak-to-fibroatheroma
#16
Benoît Ho-Tin-Noé, Sophie Vo, Richard Bayles, Stephen Ferrière, Hayette Ladjal, Sondes Toumi, Catherine Deschildre, Véronique Ollivier, Jean-Baptiste Michel
Recent studies have shown that in addition to being major constituents of the atheromatous core, solid cholesterol crystals (CCs) promote atherosclerotic lesion development and rupture by causing mechanical damage and exerting cytotoxic and pro-inflammatory effects. These findings suggest that targeting CCs might represent a therapeutic strategy for plaque stabilisation. However, little is known about how cholesterol crystallisation is initiated in human atherothrombotic disease. Here, we investigated these mechanisms...
December 31, 2016: Journal of Pathology
https://www.readbyqxmd.com/read/28032260/engaging-an-urban-african-american-community-to-deliver-cognitive-health-education-to-breast-cancer-survivors
#17
Jennifer Bail, Timiya S Nolan, Jacqueline B Vo, Silvia Gisiger-Camata, Karen Meneses
Little is known about cognitive changes among African American (AA) breast cancer survivors (BCS). Here, we report our experience with engagement of leaders of urban AA churches in Birmingham, Alabama to deliver and evaluate Think Well: Healthy Living to Improve Cognitive Function, an educational cognitive health program for BCS. The Think Well team engaged leaders of urban AA churches using a 7-step process: 1) identify leaders, 2) develop connection with leaders, 3) assess AA community preferences, 4) tailor for cultural relevance, 5) plan seminars, 6) deliver seminars, and 7) evaluate cultural relevance and overall program quality...
December 28, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28031723/economic-report-on-the-cost-of-dengue-fever-in-vietnam-case-of-a-provincial-hospital
#18
Luyen Dinh Pham, Nhat Huy Tran Phung, Nguyen Tu Dang Le, Trung Quang Vo
BACKGROUND: Dengue is a mosquito-borne viral illness with the world's fastest rate of infection. In 2014, Vietnam had recorded 43,000 cases in 53 provinces, with 28 deaths. MATERIALS AND METHODS: A 6-month cross-sectional study was conducted from September 2015 to March 2016 at Cu Chi General Hospital. Cost of illness in this study was estimated under the incidence-based approach from the societal perspective. RESULTS: The average cost per case was US$139...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28012217/association-of-increased-urinary-albumin-with-risk-of-incident-clinical-fracture-and-rate-of-hip-bone-loss-the-osteoporotic-fractures-in-men-study
#19
Howard A Fink, Tien N Vo, Lisa Langsetmo, Joshua I Barzilay, Jane A Cauley, John T Schousboe, Eric S Orwoll, Muna T Canales, Areef Ishani, Nancy E Lane, Kristine E Ensrud
Prior studies suggest that increased urine albumin is associated with a heightened fracture risk in women, but results in men are unclear. We used data from MrOS, a prospective cohort study of community-dwelling men aged ≥65 years, to evaluate the association of increased urine albumin with subsequent fractures and annualized rate of hip bone loss. We calculated albumin/creatinine ratio (ACR) from urine collected at the 2003-05 visit. Subsequent clinical fractures were ascertained from triannual questionnaires and centrally adjudicated by review of radiographic reports...
December 24, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28009860/pore-size-and-concentration-effect-of-mesoporous-silica-nanoparticles-on-the-coefficient-of-thermal-expansion-and-optical-transparency-of-poly-ether-sulfone-films
#20
Nhat Tri Vo, Astam K Patra, Dukjoon Kim
Mesoporous silica nanoparticles (MSNs) with uniform size (<50 nm) yet with different pore diameters were synthesized, and used as fillers in poly(ether sulfone) (PES) films in order to decrease their coefficient of thermal expansion (CTE) without sacrificing optical transparency. Here, both CTE and optical transparency of the MSN/PES nanocomposite films gradually decreased with increasing MSN concentration. The PES films containing MSNs with larger pores showed the best performance in CTE and optical transparency...
December 23, 2016: Physical Chemistry Chemical Physics: PCCP
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