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https://www.readbyqxmd.com/read/29775731/targeted-and-controlled-drug-delivery-by-multifunctional-mesoporous-silica-nanoparticles-with-internal-fluorescent-conjugates-and-external-polydopamine-and-graphene-oxide-layers
#1
Anh-Vy Tran, KyuHwan Shim, Thu-Thao Vo Thi, Jeong-Keun Kook, Seong Soo A An, Sang-Wha Lee
This study demonstrated the targeted delivery and controlled release of cisplatin drug molecules from doubly decorated mesoporous silica nanoparticles (MSNs), which were internally grafted with fluorescent conjugates and externally coated with polydopamine (PDA) and graphene oxide (GO) layers. The brush-like internal conjugates conferred fluorescent functionality and high capacity of cisplatin loading into MSNs, as well as contributing to a sustained release of the cisplatin through a porous channel with the assistance of external PDA layer...
May 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29775412/inhibitor-of-lysyl-oxidase-improves-cardiac-function-and-the-collagen-mmp-profile-in-response-to-volume-overload
#2
Elia C El Hajj, Milad C El Hajj, Van K Ninh, Jason D Gardner
The cardiac extracellular matrix is a complex architectural network that serves many functions including providing structural and biochemical support to surrounding cells, and regulating intercellular signaling pathways. Cardiac function is directly affected by extracellular matrix (ECM) composition, and alterations of the ECM contribute to progression of heart failure. Initially, collagen deposition is an adaptive response that aims to preserve tissue integrity and maintain normal ventricular function. However, the synergistic effects of the pro-inflammatory and pro-fibrotic responses induce a vicious cycle which causes excess activation of myofibroblasts, significantly increasing collagen deposition and accumulation in the matrix...
May 18, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29771295/the-association-between-objectively-measured-physical-activity-and-subsequent-health-care-utilization-in-older-men
#3
Lisa Langsetmo, Allyson M Kats, Peggy M Cawthon, Jane A Cauley, Tien N Vo, Brent C Taylor, Marcia L Stefanick, Nancy E Lane, Katie L Stone, Eric S Orwoll, John T Schousboe, Kristine E Ensrud
Background: To examine the associations between objective physical activity measures and subsequent health care utilization. Methods: We studied 1,283 men (mean age 79.1 years, SD 5.3) participating in the Osteoporotic Fractures in Men Study. Participants wore a SenseWear® Pro Armband monitor for 1 week. Data was summarized as daily (i) step counts, (ii) total energy expenditure, (iii) active energy expenditure, and (iv) activity time (sedentary, ≥ light, ≥ moderate)...
October 9, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29770398/electronic-properties-of-ag-doped-zno-dft-hybrid-functional-study
#4
Saeed Masoumi, Ebrahim Nadimi, Faramarz Hossein-Babaei
Studying the possibility of a p-type conduction mechanism in the Ag-doped ZnO can clarify persisting ambiguities in the related materials and devices. Here, utilizing the first principles study by hybrid functional calculations, we conclude that the potential acceptor defects AgZn and VZn are rare in the low Fermi level conditions required for p-type conduction and, hence, can hardly contribute to the hole generation in ZnO regardless of the assumed O-rich condition. Our results also reveal the exothermicity of the reaction between VO and AgZn to form the complex defect VO-2AgZn which is shown to be a less effective donor than VO...
May 17, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29769718/ankrd16-prevents-neuron-loss-caused-by-an-editing-defective-trna-synthetase
#5
My-Nuong Vo, Markus Terrey, Jeong Woong Lee, Bappaditya Roy, James J Moresco, Litao Sun, Hongjun Fu, Qi Liu, Thomas G Weber, John R Yates, Kurt Fredrick, Paul Schimmel, Susan L Ackerman
Editing domains of aminoacyl tRNA synthetases correct tRNA charging errors to maintain translational fidelity. A mutation in the editing domain of alanyl tRNA synthetase (AlaRS) in Aars sti mutant mice results in an increase in the production of serine-mischarged tRNAAla and the degeneration of cerebellar Purkinje cells. Here, using positional cloning, we identified Ankrd16, a gene that acts epistatically with the Aars sti mutation to attenuate neurodegeneration. ANKRD16, a vertebrate-specific protein that contains ankyrin repeats, binds directly to the catalytic domain of AlaRS...
May 16, 2018: Nature
https://www.readbyqxmd.com/read/29768340/the-patient-general-satisfaction-of-mandibular-single-implant-overdentures-and-conventional-complete-dentures-study-protocol-for-a-randomized-crossover-trial
#6
Manabu Kanazawa, Mariko Tanoue, Anna Miyayasu, Shin Takeshita, Daisuke Sato, Mari Asami, Thuy Vo Lam, Khaing Myat Thu, Ken Oda, Yuriko Komagamine, Shunsuke Minakuchi, Jocelyne Feine
BACKGROUND: Mandibular overdentures retained by a single implant placed in the midline of edentulous mandible have been reported to be more comfortable and function better than complete dentures. Although single-implant overdentures are still more costly than conventional complete dentures, there are a few studies which investigated whether mandibular single-implant overdentures are superior to complete dentures when patient general satisfaction is compared. The aim of this study is to assess patient general satisfaction with mandibular single-implant overdentures and complete dentures...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29767985/imaging-nanometer-phase-coexistence-at-defects-during-the-insulator-metal-phase-transformation-in-vo-2-thin-films-by-resonant-soft-x-ray-holography
#7
Luciana Vidas, Christian Guenther, Timothy Miller, Bastian Pfau, Daniel Perez, Elias Martinez, Michael Schneider, Erik Guehrs, Robert E Marvel, Kent Hallman, Richard F Haglund, Stefan Eisebitt, Simon Wall
We use resonant soft X-ray holography to image the insulator-metal phase transition in vanadium dioxide with element and polarization specificity and nanometer spatial resolution. We observe that nanoscale inhomogenity in the film results in spatial-dependent transition pathways between the insulating and metallic states. Additional nanoscale phases form in the vicinity of defects which are not apparent in the initial or final states of the system, which would be missed in area-integrated X-ray absorption measurements...
May 16, 2018: Nano Letters
https://www.readbyqxmd.com/read/29767968/screw-type-motion-and-its-impact-on-cooperativity-in-bana-2-fe-vo-4-2
#8
Anna Reuß, Vadim Ksenofontov, Joshua Tapp, Dirk Wulferding, Peter Lemmens, Martin Panthöfer, Angela Möller
BaNa2 Fe[VO4 ]2 contains a Jahn-Teller active ion (FeII , 3d6 , high-spin) in an octahedral coordination. On the basis of a combination of temperature-dependent X-ray diffraction and Mössbauer and Raman spectroscopies, we demonstrate the coupling of lattice dynamics with the electronic ground state of FeII . We identify three lattice modes combined to an effective canted screw- type motion that drives the structural transition around room temperature from the high-temperature ( P3̅) via intermediate phases to the low-temperature phase ( C2/ c)...
May 16, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29766190/toxicity-assessment-and-mechanistic-investigation-of-engineered-monoclinic-vo-2-nanoparticles
#9
Di Wu, Qianqian Su, Yang Li, Chen Zhang, Xian Qin, Yuan-Yuan Liu, Wen-Song Xi, Yanfeng Gao, Aoneng Cao, Xiaogang Liu, Haifang Wang
Growing interest in monoclinic VO2 nanoparticles (NPs) among consumers and the industries of window coatings, solar sensors etc. has brought particular attention to their safety concerns. The toxicity of this new class of nanomaterials in bacterial ecosystems has not yet been evaluated. The degree of crystallinity is a significant parameter that determines the performance of materials. However, the previously reported methods for toxicity assessment have neglected its influence. In this work, we systematically evaluated the toxicity of VO2 NPs with different degrees of crystallinity to four typical bacterial strains and studied the influence of physicochemical properties and aging treatment on their antibacterial effect...
May 16, 2018: Nanoscale
https://www.readbyqxmd.com/read/29763604/attenuation-of-macrophage-accumulation-and-polarisation-in-obese-diabetic-mice-by-a-small-molecule-significantly-improved-insulin-sensitivity
#10
Sandip Mukherjee, Snehasis Das, Dipanjan Chattopadhyay, Shuvasree Sarkar, Subhendu Kumar Chatterjee, Dhrubajyoti Talukdar, Sutapa Mukherjee, Subeer S Majumder, Satinath Mukhopadhyay, Mihir K Chaudhuri, Samir Bhattacharya
Accumulation and polarization of anti-inflammatory M2 to proinflammatory M1 macrophage in the adipose tissue of obese diabetic mice is an important pathogenic signature. It worsens lipid induced inflammation and insulin resistance. Here we demonstrate that a small molecule, a peroxyvanadate compound i.e. DmpzH [VO(O2 )2 (dmpz)] or dmp, could robustly decrease macrophage infiltration, accumulation and their polarization in high fat diet (HFD) induced obese diabetic mice. In searching the underlying mechanism it was revealed that SIRT1 level was strikingly low in the inflamed adipose tissue of HFD mice as compared to mice fed with standard diet (SD)...
May 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29762540/the-role-of-peroxisome-proliferator-activated-receptors-and-their-transcriptional-coactivators-gene-variations-in-human-trainability-a-systematic-review
#11
REVIEW
Miroslav Petr, Petr Stastny, Adam Zajac, James J Tufano, Agnieszka Maciejewska-Skrendo
BACKGROUND: The peroxisome proliferator-activated receptors ( PPARA , PPARG , PPARD ) and their transcriptional coactivators' ( PPARGC1A , PPARGC1B ) gene polymorphisms have been associated with muscle morphology, oxygen uptake, power output and endurance performance. The purpose of this review is to determine whether the PPARs and/or their coactivators' polymorphisms can predict the training response to specific training stimuli. METHODS: In accordance with the Preferred Reporting Items for Systematic Reviews and Meta Analyses, a literature review has been run for a combination of PPARs and physical activity key words...
May 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29761310/characteristics-of-patients-with-a-relatively-greater-minimum-ve-vco-2-against-peak-vo-2-and-impaired-exercise-tolerance
#12
Taisuke Nakade, Hitoshi Adachi, Makoto Murata, Shigeru Oshima
PURPOSE: Cardiopulmonary exercise testing (CPX) is used to evaluate functional capacity and assess prognosis in cardiac patients. Ventilatory efficiency (VE/VCO2 ) reflects ventilation-perfusion mismatch; the minimum VE/VCO2 value (minVE/VCO2 ) is representative of pulmonary arterial blood flow in individuals without pulmonary disease. Usually, minVE/VCO2 has a strong relationship with the peak oxygen uptake (VO2 ), but dissociation can occur. Therefore, we investigated the relationship between minVE/VCO2 and predicted peak VO2 (peak VO2 %) and evaluated the parameters associated with a discrepancy between these two parameters...
May 14, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29758437/flexible-3d-fe-vo-2-core-shell-mesh-a-highly-efficient-and-easy-recycling-catalyst-for-the-removal-of-organic-dyes
#13
Jing Li, Ruoqi Wang, Zhen Su, Dandan Zhang, Heping Li, Youwei Yan
Nowadays, it is extremely urgent to search for efficient and effective catalysts for water purification due to the severe worldwide water-contamination crises. Here, 3D Fe@VO2 core-shell mesh, a highly efficient catalyst toward removal of organic dyes with excellent recycling ability in the dark is designed and developed for the first time. This novel core-shell structure is actually 304 stainless steel mesh coated by VO2 , fabricated by an electrophoretic deposition method. In such a core-shell structure, Fe as the core allows much easier separation from the water, endowing the catalyst with a flexible property for easy recycling, while VO2 as the shell is highly efficient in degradation of organic dyes with the addition of H2 O2 ...
May 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29754929/one-size-fits-all-peak-vo-2-a-dream-or-a-nightmare
#14
EDITORIAL
Jeness Campodonico, Piergiuseppe Agostoni
No abstract text is available yet for this article.
July 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29754647/effects-of-a-12-week-mhealth-program-on-peak-vo-2-and-physical-activity-patterns-after-completing-cardiac-rehabilitation-a-randomized-controlled-trial
#15
Brian D Duscha, Lucy W Piner, Mahesh P Patel, Karen P Craig, Morgan Brady, Robert W McGarrah, Connie Chen, William E Kraus
BACKGROUND: Site-based cardiac rehabilitation (CR) provides supervised exercise, education and motivation for patients. Graduates of CR have improved exercise tolerance. However, when participation in CR ceases, adherence to regular physical activity often declines, consequently leading to worsening risk factors and clinical events. Therefore, the purpose of this pilot study was to evaluate if a mHealth program could sustain the fitness and physical activity levels gained during CR. METHODS AND RESULTS: A 12-week mHealth program was implemented using physical activity trackers and health coaching...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29754196/painful-stimulation-of-a-sensitized-site-in-the-forearm-inhibits-ipsilateral-trigeminal-nociceptive-blink-reflexes
#16
Peter D Drummond, Ashlea Bell, Lechi Vo
Exposure to moderate levels of ultraviolet B radiation (UVB) is painless but nevertheless induces an inflammatory response that sensitizes primary afferent nociceptors. Subsequently, heating the UVB-treated site can sensitize spinal nociceptors. We used a repeated-measures design to determine whether heating the UVB-treated site also triggers ipsilateral inhibitory controls. Specifically, a 2-cm diameter site on the forearm of 20 participants was exposed to UVB at twice the minimum erythema dose. 48 h later mechanical and thermal sensitivity had increased at the UVB-treated site, indicating primary hyperalgesia...
May 12, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29754144/mgatp-hydrolysis-destabilizes-the-interaction-between-subunit-h-and-yeast-v1-atpase-highlighting-h-s-role-in-v-atpase-regulation-by-reversible-disassembly
#17
Stuti Sharma, Rebecca A Oot, Stephan Wilkens
Vacuolar H+-ATPases (V-ATPases; V1Vo-ATPases) are rotary motor proton pumps that acidify intracellular compartments and in some tissues, the extracellular space. V-ATPase is regulated by reversible disassembly into autoinhibited V1-ATPase and Vo proton channel sectors. An important player in V-ATPase regulation is subunit H, which binds at the interface of V1 and Vo. H is required for MgATPase activity in holo V-ATPase, but also for stabilizing the MgADP inhibited state in membrane detached V1. However, how H fulfills these two functions is poorly understood...
May 12, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29752597/the-higher-prevalence-of-developmental-defects-of-enamel-in-the-dioxin-affected-region-than-non-dioxin-affected-region-result-from-a-cross-sectional-study-in-vietnam
#18
Vo Truong Nhu Ngoc, Le Thi Huong, Bui Van Nhon, Ngo Thi Minh Tan, Pham Van Thuc, Vo Thi Thu Hien, Truong Manh Dung, Ngo Van Toan, Le Quynh Anh, Le Hoang Son, Thien Chu-Dinh, Dinh-Toi Chu
Developmental defects of enamel (DDE) are induced and regulated by several factors including genetics and the environment. There is evidence showing that dioxin in polluted areas has a strong effect on the health and development of teeth. However, there has been no study on DDE in the dioxin-affected regions in Vietnam. To identify the effect of dioxin on the prevalence of DDE in studied areas in Vietnam, a cross-sectional study was conducted in 2200 adults in the A Luoi district in the Thua Thien Hue province (the dioxin-affected region) and in the Kim Bang district in the Ha Nam province (dioxin-unaffected region) in 2015...
May 11, 2018: Odontology
https://www.readbyqxmd.com/read/29751130/association-of-high-resolution-peripheral-quantitative-computed-tomography-hr-pqct-bone-microarchitectural-parameters-with-previous-clinical-fracture-in-older-men-the-osteoporotic-fractures-in-men-mros-study
#19
Howard A Fink, Lisa Langsetmo, Tien N Vo, Eric S Orwoll, John T Schousboe, Kristine E Ensrud
High-resolution peripheral quantitative computed tomography (HR-pQCT) assesses both volumetric bone mineral density (vBMD) and trabecular and cortical microarchitecture. However, studies of the association of HR-pQCT parameters with fracture history have been small, predominantly limited to postmenopausal women, often performed limited adjustment for potential confounders including for BMD, and infrequently assessed strength or failure measures. We used data from the Osteoporotic Fractures in Men (MrOS) study, a prospective cohort study of community-dwelling men aged ≥65 years, to evaluate the association of distal radius, proximal (diaphyseal) tibia and distal tibia HR-pQCT parameters measured at the Year 14 (Y14) study visit with prior clinical fracture...
May 8, 2018: Bone
https://www.readbyqxmd.com/read/29747066/spontaneous-dna-damage-to-the-nuclear-genome-promotes-senescence-redox-imbalance-and-aging
#20
Andria R Robinson, Matthew J Yousefzadeh, Tania A Rozgaja, Jin Wang, Xuesen Li, Jeremy S Tilstra, Chelsea H Feldman, Siobhán Q Gregg, Caroline H Johnson, Erin M Skoda, Marie-Céline Frantz, Harris Bell-Temin, Hannah Pope-Varsalona, Aditi U Gurkar, Luigi A Nasto, Renã A S Robinson, Heike Fuhrmann-Stroissnigg, Jolanta Czerwinska, Sara J McGowan, Nadiezhda Cantu-Medellin, Jamie B Harris, Salony Maniar, Mark A Ross, Christy E Trussoni, Nicholas F LaRusso, Eugenia Cifuentes-Pagano, Patrick J Pagano, Barbara Tudek, Nam V Vo, Lora H Rigatti, Patricia L Opresko, Donna B Stolz, Simon C Watkins, Christin E Burd, Claudette M St Croix, Gary Siuzdak, Nathan A Yates, Paul D Robbins, Yinsheng Wang, Peter Wipf, Eric E Kelley, Laura J Niedernhofer
Accumulation of senescent cells over time contributes to aging and age-related diseases. However, what drives senescence in vivo is not clear. Here we used a genetic approach to determine if spontaneous nuclear DNA damage is sufficient to initiate senescence in mammals. Ercc1-/∆ mice with reduced expression of ERCC1-XPF endonuclease have impaired capacity to repair the nuclear genome. Ercc1-/∆ mice accumulated spontaneous, oxidative DNA damage more rapidly than wild-type (WT) mice. As a consequence, senescent cells accumulated more rapidly in Ercc1-/∆ mice compared to repair-competent animals...
April 13, 2018: Redox Biology
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