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https://www.readbyqxmd.com/read/28636361/a-machine-learning-assisted-approach-for-discovering-novel-inhibitors-targeting-bromodomain-containing-protein-4
#1
Jing Xing, Wenchao Lu, Rongfeng Liu, Yulan Wang, Yiqian Xie, Hao Zhang, Zhe Shi, Hao Jiang, Yu-Chih Liu, Kaixian Chen, Hualiang Jiang, Cheng Luo, Mingyue Zheng
Bromodomain-containing protein 4 (BRD4) is implicated in the pathogenesis of a number of different cancers, inflammatory diseases and heart failure. Much effort has been dedicated toward discovering novel scaffold BRD4 inhibitors (BRD4is) with different selectivity profiles and potential anti-resistance properties. Structure-based drug design (SBDD) and virtual screening (VS) are the most frequently used approaches. Here, we demonstrate a novel, structure-based VS approach that uses machine-learning algorithms trained on the priori structure and activity knowledge to predict the likelihood that a compound is a BRD4i based on its binding pattern with BRD4...
June 21, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28632905/the-malleable-brain-plasticity-of-neural-circuits-and-behavior-a-review-from-students-to-students
#2
REVIEW
Natascha Schaefer, Carola Rotermund, Eva-Maria Blumrich, Mychael V Lourenco, Pooja Joshi, Regina U Hegemann, Sumit Jamwal, Nilufar Ali, Ezra Michelet García Romero, Sorabh Sharma, Shampa Ghosh, Jitendra K Sinha, Hannah Loke, Vishal Jain, Katarzyna Lepeta, Ahmad Salamian, Mahima Sharma, Mojtaba Golpich, Katarzyna Nawrotek, Ramesh K Paidi, Sheila M Shahidzadeh, Tetsade Piermartiri, Elham Amini, Veronica Pastor, Yvette Wilson, Philip A Adeniyi, Ashok K Datusalia, Benham Vafadari, Vedangana Saini, Edna Suárez-Pozos, Neetu Kushwah, Paula Fontanet, Anthony J Turner
One of the most intriguing features of the brain is its ability to be malleable, allowing it to adapt continually to changes in the environment. Specific neuronal activity patterns drive long-lasting increases or decreases in the strength of synaptic connections, referred to as long-term potentiation (LTP) and long-term depression (LTD) respectively. Such phenomena have been described in a variety of model organisms, which are used to study molecular, structural, and functional aspects of synaptic plasticity...
June 20, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28632011/essential-public-health-competencies-for-medical-students-establishing-a-consensus-in-family-medicine
#3
Christopher P Morley, Scott R Rosas, Ranit Mishori, William Jordan, Yumi Shitama Jarris, Family Medicine/Public Health Competencies Work Group, Jacob Prunuske
Phenomenon: The integration of public health (PH) competency training into medical education, and further integration of PH and primary care, has been urged by the U.S. Institute of Medicine. However, PH competencies are numerous, and no consensus exists over which competencies are most important for adoption by current trainees. Our objective was to conduct a group concept mapping exercise with stakeholders identifying the most important and feasible PH skills to incorporate in medical and residency curricula...
March 2, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/28632010/designing-a-national-longitudinal-faculty-development-curriculum-focused-on-educational-scholarship-process-outcomes-and-lessons-learned
#4
Latha Chandran, Maryellen E Gusic, J Lindsey Lane, Constance D Baldwin
PROBLEM: Clinical educators at U.S. academic health centers are frequently disadvantaged in the academic promotion system, lacking needed faculty development, mentoring, and networking support. INTERVENTION: In 2006, we implemented the national Educational Scholars Program to offer faculty development in educational scholarship for early career educators in pediatrics. We aimed to provide them with skills, experience, and initial success in educational scholarship and dissemination...
March 2, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/28631734/learning-relative-values-in-the-striatum-induces-violations-of-normative-decision-making
#5
Tilmann A Klein, Markus Ullsperger, Gerhard Jocham
To decide optimally between available options, organisms need to learn the values associated with these options. Reinforcement learning models offer a powerful explanation of how these values are learnt from experience. However, human choices often violate normative principles. We suggest that seemingly counterintuitive decisions may arise as a natural consequence of the learning mechanisms deployed by humans. Here, using fMRI and a novel behavioural task, we show that, when suddenly switched to novel choice contexts, participants' choices are incongruent with values learnt by standard learning algorithms...
June 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28630951/phenotyping-hypotensive-patients-in-critical-care-using-hospital-discharge-summaries
#6
Yang Dai, Sharukh Lokhandwala, William Long, Roger Mark, Li-Wei H Lehman
Among critically-ill patients, hypotension represents a failure in compensatory mechanisms and may lead to organ hypoperfusion and failure. In this work, we adopt a data-driven approach for phenotype discovery and visualization of patient similarity and cohort structure in the intensive care unit (ICU). We used Hierarchical Dirichlet Process (HDP) as a nonparametric topic modeling technique to automatically learn a d-dimensional feature representation of patients that captures the latent "topic" structure of diseases, symptoms, medications, and findings documented in hospital discharge summaries...
February 2017: IEEE-EMBS International Conference on Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28630839/septic-arthritis-of-the-hip-complicated-by-secondary-fungal-superinfection
#7
Scott Matthews, Sam Sloan, Daniel McCaffrey, Angel Ruiz
INTRODUCTION: Fungal joint infection can lead to serious consequences for those affected. It can often be a delayed diagnosis due to initial negative organism growth or lack of clinician awareness. Treatment should be early and aggressive to prevent patient morbidity and mortality. CASE REPORT: We present a case of staphylococcal septic arthritis of the native hip joint with secondary superinfection by Candida albicans in a young patient with no appreciable risk factors...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28630026/what-have-we-learned-on-aging-from-omics-studies
#8
REVIEW
Alessandro Cellerino, Alessandro Ori
Aging is a complex process. Transcriptomic studies of the last decade have identified genes and pathways that are regulated during aging in multiple species and organs. Yet, since a manifold of pathways are regulated and the amplitude of regulation is often small, reproducibility across studies is moderate and disentangling cause-consequence relationships has proven challenging. Here, we review a number of consistent findings in the light of more recent, longitudinal studies and of studies combining transcriptomics and proteomics that identified deregulation of protein biosynthetic pathways as an early event and likely driver of aging...
June 16, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28629300/dynamic-interplay-of-pharmacy-learners-during-a-solid-organ-transplantation-learning-experience
#9
Jonathan H Sin, Hanlin Li, Nicholas Jandovitz, Madeline King, Demetra S Tsapepas
Institutions with established clinical pharmacy services have the ability to offer focused patient care learning experiences, often led by a clinical specialist, for pharmacy residents and pharmacy students. Since all parties are continually involved in professional development and lifelong learning, the aforementioned groups can all be considered "pharmacy learners." By utilizing the dynamic interplay and collaboration between pharmacy learners through direct and nondirect patient care activities, experiential and educational opportunities may be improved and enhanced for each learner...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28628075/using-the-nln-faculty-preparation-for-global-experiences-toolkit-for-successful-application-for-the-fulbright-scholar-award
#10
Zepure Samawi, Lisa Capps, Ruth Hansen
With an increasingly global world and the migration of diverse populations, nurse faculty have opportunities to learn and share varied perspectives through involvement internationally in research, teaching, and practice. The National League for Nursing (NLN) joins with the World Health Organization and the International Council of Nurses to promote international nursing standards. One way in which nursing faculty can contribute to this goal is by pursuing international education, research, and service as a Fulbright scholar...
July 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/28625880/predicting-biomedical-metadata-in-cedar-a-study-of-gene-expression-omnibus-geo
#11
Maryam Panahiazar, Michel Dumontier, Olivier Gevaert
A crucial and limiting factor in data reuse is the lack of accurate, structured, and complete descriptions of data, known as metadata. Towards improving the quantity and quality of metadata, we propose a novel metadata prediction framework to learn associations from existing metadata that can be used to predict metadata values. We evaluate our framework in the context of experimental metadata from the Gene Expression Omnibus (GEO). We applied four rule mining algorithms to the most common structured metadata elements (sample type, molecular type, platform, label type and organism) from over 1,3 million GEO records...
June 15, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28625154/expanding-the-genetic-alphabet
#12
Janelle Weaver
Synthetic biologists have engineered a semisynthetic organism that can store increased genetic information using an alphabet consisting of six letters that form three base pairs. Janelle Weaver learns how they did it.
June 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/28625111/successful-adaptation-of-a-research-methods-course-in-south-america
#13
Leonardo Tamariz, Diego Vasquez, Cecilia Loor, Ana Palacio
BACKGROUND: South America has low research productivity. The lack of a structured research curriculum is one of the barriers to conducting research. OBJECTIVE: To report our experience adapting an active learning-based research methods curriculum to improve research productivity at a university in Ecuador. DESIGN: We used a mixed-method approach to test the adaptation of the research curriculum at Universidad Catolica Santiago de Guayaquil...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28624434/brain-glucose-metabolism-role-of-wnt-signaling-in-the-metabolic-impairment-in-alzheimer-s-disease
#14
REVIEW
Pedro Cisternas, Nibaldo C Inestrosa
The brain is an organ that has a high demand for glucose. In the brain, glucose is predominantly used in energy production, with almost 70% of the energy used by neurons. The importance of the energy requirement in neurons is clearly demonstrated by the fact that all neurodegenerative disorders exhibit a critical metabolic impairment that includes decreased glucose uptake/utilization and decreased mitochondrial activity, with a consequent diminution in ATP production. In fact, in Alzheimer's disease, the measurement of the general metabolic rate of the brain has been reported to be an accurate tool for diagnosis...
June 14, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28623455/-single-incision-laparoscopy-current-status
#15
REVIEW
H Weiss, C Mittermair, M Weiss
BACKGROUND: Since the introduction of single incision laparoscopy (SIL), there has been disagreement among professional societies regarding a general recommendation for the use of this minimally invasive method. OBJECTIVES: Determination of evidence-based advantages of SIL compared to multiport laparoscopy (MPL). MATERIALS AND METHODS: Description of recent technical developments and evaluation of prospective randomized clinical trials and valid meta-analyses with regard to organ-specific procedures...
June 16, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28622407/challenges-and-lessons-learned-in-implementing-a-community-academic-partnership-for-drug-prevention-in-a-native-hawaiian-community
#16
Susana Helm, Kanoelani Davis, Anonymous Youth Participants Haumana
OBJECTIVE: The broad purpose of this project is to improve health in Native Hawaiian communities through the prevention of substance use. Our community-academic partnership (CAP) team developed an intervention called Puni Ke Ola for this purpose. This paper provides a brief overview of the intervention, then describes challenges and lessons learned in piloting Puni Ke Ola. METHODS: A single module of the Puni Ke Ola intervention was implemented, after which the intervention leaders (N=3) convened for a debriefing meeting...
June 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28621695/learning-challenges-and-sustainable-development-a-methodological-perspective
#17
Laura Seppänen
BACKGROUND: Sustainable development requires learning, but the contents of learning are often complex and ambiguous. This requires new integrated approaches from research. It is argued that investigation of people's learning challenges in every-day work is beneficial for research on sustainable development. OBJECTIVE: The aim of the paper is to describe a research method for examining learning challenges in promoting sustainable development. This method is illustrated with a case example from organic vegetable farming in Finland...
June 14, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28620489/organizational-knowledge-and-capabilities-in-healthcare-deconstructing-and-integrating-diverse-perspectives
#18
REVIEW
Jenna M Evans, Adalsteinn Brown, G Ross Baker
Diverse concepts and bodies of work exist in the academic literature to guide research and practice on organizational knowledge and capabilities. However, these concepts have largely developed in parallel with minimal cross-fertilization, particularly in the healthcare domain. This contributes to confusion regarding conceptual boundaries and relationships, and to a lack of application of potentially useful evidence. The aim of this article is to assess three concepts associated with organizational knowledge content-intellectual capital, organizational core competencies, and dynamic capabilities-and to propose an agenda for future research...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28620366/vibrio-vulnificus-an-environmental-and-clinical-burden
#19
REVIEW
Sing-Peng Heng, Vengadesh Letchumanan, Chuan-Yan Deng, Nurul-Syakima Ab Mutalib, Tahir M Khan, Lay-Hong Chuah, Kok-Gan Chan, Bey-Hing Goh, Priyia Pusparajah, Learn-Han Lee
Vibrio vulnificus is a Gram negative, rod shaped bacterium that belongs to the family Vibrionaceae. It is a deadly, opportunistic human pathogen which is responsible for the majority of seafood-associated deaths worldwide. V. vulnificus infection can be fatal as it may cause severe wound infections potentially requiring amputation or lead to sepsis in susceptible individuals. Treatment is increasingly challenging as V. vulnificus has begun to develop resistance against certain antibiotics due to their indiscriminate use...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28620199/predicting-the-outcomes-of-organic-reactions-via-machine-learning-are-current-descriptors-sufficient
#20
G Skoraczyński, P Dittwald, B Miasojedow, S Szymkuć, E P Gajewska, B A Grzybowski, A Gambin
As machine learning/artificial intelligence algorithms are defeating chess masters and, most recently, GO champions, there is interest - and hope - that they will prove equally useful in assisting chemists in predicting outcomes of organic reactions. This paper demonstrates, however, that the applicability of machine learning to the problems of chemical reactivity over diverse types of chemistries remains limited - in particular, with the currently available chemical descriptors, fundamental mathematical theorems impose upper bounds on the accuracy with which raction yields and times can be predicted...
June 15, 2017: Scientific Reports
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