Jéssica Bezerra Maciel, Hortência Ribeiro Liberato, Antônio Wlisses da Silva, João Pedro Vieira da Silva, Francisco das Chagas L Pinto, Emanuela de Lima Rebouças, Francisco Sydney Henrique da Silva, Maria Kuerislene Amâncio Ferreira, Marcia Machado Marinho, Emmanuel Silva Marinho, Otília Deusdênia Loiola Pessoa, Paulo Goberlânio de Barros Silva, Andrelina Noronha Coelho de-Souza, Maria Izabel Florindo Guedes, Andreia Ferreira de Castro Gomes, Jane Eire Silva Alencar de Menezes, Helcio Silva Dos Santos
This is the first study to analyze the anti-inflammatory and antinociceptive effect of withanicandrin, isolated from Datura Ferox leaves, and the possible mechanism of action involved in adult zebrafish (ZFa). To this end, the animals were treated intraperitoneally (i.p.) with withanicandrin (4; 20 and 40 mg/kg; 20 μL) and subjected to locomotor activity and acute toxicity. Nociception tests were also carried out with chemical agents, in addition to tests to evaluate inflammatory processes induced by κ-Carrageenan 1...
April 19, 2024: Chemistry & Biodiversity