Min Young Kim, Hyun Young Shin, Sung Chun Cho, Sohae Yang, Aseer Intisar, Hyeong Jung Woo, Youn-Suk Choi, Chang-Lim You, Jong-Sun Kang, Yun-Il Lee, Sang Chul Park, Kyungmoo Yea, Tae Gyu Oh, Michael Downes, Ronald M Evans, Minseok S Kim
While the world is rapidly transforming into a superaging society, pharmaceutical approaches to treat sarcopenia have hitherto not been successful due to their insufficient efficacy and failure to specifically target skeletal muscle cells (skMCs). Although electrical stimulation (ES) is emerging as an alternative intervention, its efficacy toward treating sarcopenia remains unexplored. In this study, we demonstrate a silver electroceutical technology with the potential to treat sarcopenia. First, we developed a high-throughput ES screening platform that can simultaneously stimulate 15 independent conditions, while utilizing only a small number of human-derived primary aged/young skMCs (hAskMC/hYskMC)...
August 15, 2023: Proceedings of the National Academy of Sciences of the United States of America