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Electroceutical

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https://www.readbyqxmd.com/read/29797377/vagus-nerve-stimulation-promotes-gastric-emptying-by-increasing-pyloric-opening-measured-with-magnetic-resonance-imaging
#1
K-H Lu, J Cao, S Oleson, M P Ward, R J Phillips, T L Powley, Z Liu
BACKGROUND: Vagus nerve stimulation (VNS) is an emerging electroceutical therapy for remedying gastric disorders that are poorly managed by pharmacological treatments and/or dietary changes. Such therapy seems promising as the vagovagal neurocircuitry modulates the enteric nervous system to influence gastric functions. METHODS: Here, the modulatory effects of left cervical VNS on gastric emptying in rats were quantified using a (i) feeding protocol in which the animal voluntarily consumed a postfast, gadolinium-labeled meal and (ii) a non-invasive imaging method to measure antral motility, pyloric activity and gastric emptying based on contrast-enhanced magnetic resonance imaging (MRI) and computer-assisted image processing pipelines...
May 24, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29780301/when-the-ostrich-algorithm-fails-blanking-method-affects-spike-train-statistics
#2
Kevin Joseph, Soheil Mottaghi, Olaf Christ, Thomas J Feuerstein, Ulrich G Hofmann
Modern electroceuticals are bound to employ the usage of electrical high frequency (130-180 Hz) stimulation carried out under closed loop control, most prominent in the case of movement disorders. However, particular challenges are faced when electrical recordings of neuronal tissue are carried out during high frequency electrical stimulation, both in-vivo and in-vitro . This stimulation produces undesired artifacts and can render the recorded signal only partially useful. The extent of these artifacts is often reduced by temporarily grounding the recording input during stimulation pulses...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29198041/ethical-considerations-on-novel-neuronal-interfaces
#3
Kadircan H Keskinbora, Kader Keskinbora
Wireless powered implants, each smaller than a grain of rice, have the potential to scan and stimulate brain cells. Further research may lead to next-generation brain-machine interfaces for controlling prosthetics, exoskeletons, and robots, as well as "electroceuticals" to treat disorders of the brain and body. In conditions that can be particularly alleviated with brain stimulation, the use of such mini devices may pose certain challenges. Health professionals are becoming increasingly more accountable in decision-making processes that have impacts on the life quality of individuals...
April 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29140901/state-of-the-art-techniques-in-treating-peripheral-nerve-injury
#4
Carrie A Kubiak, Theodore A Kung, David L Brown, Paul S Cederna, Stephen W P Kemp
BACKGROUND: Peripheral nerve injuries remain a major clinical concern, as they often lead to chronic disability and significant health care expenditures. Despite advancements in microsurgical techniques to enhance nerve repair, biological approaches are needed to augment nerve regeneration and improve functional outcomes after injury. METHODS: Presented herein is a review of the current literature on state-of-the-art techniques to enhance functional recovery for patients with nerve injury...
March 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29099398/electric-field-based-dressing-disrupts-mixed-species-bacterial-biofilm-infection-and-restores-functional-wound-healing
#5
Kasturi Ganesh Barki, Amitava Das, Sriteja Dixith, Piya Das Ghatak, Shomita Mathew-Steiner, Elizabeth Schwab, Savita Khanna, Daniel J Wozniak, Sashwati Roy, Chandan K Sen
OBJECTIVE: This study was designed to employ electroceutical principles, as an alternative to pharmacological intervention, to manage wound biofilm infection. Mechanism of action of a United States Food and Drug Administration-cleared wireless electroceutical dressing (WED) was tested in an established porcine chronic wound polymicrobial biofilm infection model involving inoculation with Pseudomonas aeruginosa PAO1 and Acinetobacter baumannii 19606. BACKGROUND: Bacterial biofilms represent a major wound complication...
November 2, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29054204/electroceuticals-in-medicine-the-brave-new-future
#6
Sundeep Mishra
Electroceuticals are a new category of therapeutic agents which act by targeting the neural circuits of organs. The therapy involves mapping the neural circuitry and delivering neural impulses to these specific targets. The impulse is administered via an implantable device. In cardiology besides pacemaker, defibrillation and resynchronization applications it could have usefulness in heart failure, atrial fibrillation, coronary artery disease, myocarditis, resistant hypertension, atrial and ventricular tachyarrhythmias, pulseless electrical activity, and refractory angina...
September 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28979183/nanowire-fet-based-neural-element-for-robotic-tactile-sensing-skin
#7
William Taube Navaraj, Carlos García Núñez, Dhayalan Shakthivel, Vincenzo Vinciguerra, Fabrice Labeau, Duncan H Gregory, Ravinder Dahiya
This paper presents novel Neural Nanowire Field Effect Transistors (υ-NWFETs) based hardware-implementable neural network (HNN) approach for tactile data processing in electronic skin (e-skin). The viability of Si nanowires (NWs) as the active material for υ-NWFETs in HNN is explored through modeling and demonstrated by fabricating the first device. Using υ-NWFETs to realize HNNs is an interesting approach as by printing NWs on large area flexible substrates it will be possible to develop a bendable tactile skin with distributed neural elements (for local data processing, as in biological skin) in the backplane...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28901588/graphene-in-the-design-and-engineering-of-next-generation-neural-interfaces
#8
REVIEW
Kostas Kostarelos, Melissa Vincent, Clement Hebert, Jose A Garrido
Neural interfaces are becoming a powerful toolkit for clinical interventions requiring stimulation and/or recording of the electrical activity of the nervous system. Active implantable devices offer a promising approach for the treatment of various diseases affecting the central or peripheral nervous systems by electrically stimulating different neuronal structures. All currently used neural interface devices are designed to perform a single function: either record activity or electrically stimulate tissue...
September 13, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28638319/dynamiceuticals-the-next-stage-in-personalized-medicine
#9
Jose L Perez Velazquez
The surge in the interest in personalized medicine necessitates a corresponding rational approach for implementing such individualized therapies. Dynamiceuticals represents a natural extension of the Pharmaceutical and Electroceutical fields, where the precise determination of the dynamical regimes of the pathophysiology will guide to devise therapies that ameliorate the pathology in a well-controlled manner, thus being precisely tailored toward the implementation of individualized medicine. This approach foretells to lessen side-effects and achieve superior efficacy as compared with current trial-and-error or open-loop strategies...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28554310/ion-channel-and-neurotransmitter-modulators-as-electroceutical-approaches-to-the-control-of-cancer
#10
Jack Tuszynski, Tatiana M Tilli, Michael Levin
The activities of individual cells must be tightly coordinated in order to build and maintain complex 3- dimensional body structures during embryogenesis and regeneration. Thus, one way to view cancer is within systems biology as a network disorder affecting the ability of cells to properly interact with a morphodynamic field of instructive signals that keeps proliferation and migration orchestrated toward the anatomical needs of the host organism. One layer of this set of instructive microenvironmental cues is bioelectrical...
2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28510430/nanoarchitecturing-of-natural-melanin-nanospheres-by-layer-by-layer-assembly-macroscale-anti-inflammatory-conductive-coatings-with-optoelectronic-tunability
#11
Taesik Eom, Kyungbae Woo, Whirang Cho, Jae Eun Heo, Daseul Jang, Jae In Shin, David C Martin, Jeong Jae Wie, Bong Sup Shim
Natural melanins are biocompatible conductors with versatile functionalities. Here, we report fabrication of multifunctional poly(vinyl alcohol)/melanin nanocomposites by layer-by-layer (LBL) assembly using melanin nanoparticles (MNPs) directly extracted from sepia officinalis inks. The LBL assembly offers facile manipulation of nanotextures as well as nm-thickness control of the macroscale film by varying solvent qualities. The time-resolved absorption was monitored during the process and quantitatively studied by fractal dimension and lacunarity analysis...
June 12, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28252340/electrical-stimulation-therapy-and-electroceutical-treatment-for-the-management-of-venous-leg-ulcers
#12
REVIEW
Liz Ovens
No abstract text is available yet for this article.
March 2017: British Journal of Community Nursing
https://www.readbyqxmd.com/read/28217104/priming-neural-circuits-to-modulate-spinal-reflex-excitability
#13
Stephen P Estes, Jennifer A Iddings, Edelle C Field-Fote
While priming is most often thought of as a strategy for modulating neural excitability to facilitate voluntary motor control, priming stimulation can also be utilized to target spinal reflex excitability. In this application, priming can be used to modulate the involuntary motor output that often follows central nervous system injury. Individuals with spinal cord injury (SCI) often experience spasticity, for which antispasmodic medications are the most common treatment. Physical therapeutic/electroceutic interventions offer an alternative treatment for spasticity, without the deleterious side effects that can accompany pharmacological interventions...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28181720/organic-bioelectronics-in-medicine
#14
REVIEW
S Löffler, K Melican, K P R Nilsson, A Richter-Dahlfors
A major challenge in the growing field of bioelectronic medicine is the development of tissue interface technologies promoting device integration with biological tissues. Materials based on organic bioelectronics show great promise due to a unique combination of electronic and ionic conductivity properties. In this review, we outline exciting developments in the field of organic bioelectronics and demonstrate the medical importance of these active, electronically controllable materials. Importantly, organic bioelectronics offer a means to control cell-surface attachment as required for many device-tissue applications...
July 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28078066/use-it-or-lose-it-tonic-activity-of-slow-motoneurons-promotes-their-survival-and-preferentially-increases-slow-fiber-type-groupings-in-muscles-of-old-lifelong-recreational-sportsmen
#15
Simone Mosole, Ugo Carraro, Helmut Kern, Stefan Loefler, Sandra Zampieri
Histochemistry, immuno-histochemistry, gel electrophoresis of single muscle fibers and electromyography of aging muscles and nerves suggest that: i) denervation contributes to muscle atrophy, ii) impaired mobility accelerates the process, and iii) lifelong running protects against loss of motor units. Recent corroborating results on the muscle effects of Functional Electrical Stimulation (FES) of aged muscles will be also mentioned, but we will in particular discuss how and why a lifelong increased physical activity sustains reinnervation of muscle fibers...
September 15, 2016: European Journal of Translational Myology
https://www.readbyqxmd.com/read/27830452/fabrication-of-self-expandable-niti-thin-film-devices-with-micro-electrode-array-for-bioelectric-sensing-stimulation-and-ablation
#16
Christoph Bechtold, Rodrigo Lima de Miranda, Christoph Chluba, Eckhard Quandt
Self-expandable medical devices provide mechanical functionality at a specific location of the human body and are viable for minimal invasive procedures. Besides radiopaque markers and drug-eluting coatings, next generation self-expandable devices can be equipped with additional functionality, such as conductive and flexible electrodes, which enables chronic recording of bioelectrical signals, stimulating or ablating tissue. This promises new therapeutic options in various medical fields, among them in particular neuromodulation (e...
December 2016: Biomedical Microdevices
https://www.readbyqxmd.com/read/27542331/neuro-immune-interactions-in-the-cholinergic-anti-inflammatory-reflex
#17
REVIEW
Colin Reardon
Communication between the nervous and immune systems can significantly alter immune cell function in a number of inflammatory diseases. Elegant studies have defined a basic functional circuit in a "cholinergic anti-inflammatory pathway" that highlights a unique role for the vagus nerve, and has brought about a resurgence in the field of neuro-immunology. This research has further identified that in addition to tonic signals that can restrain immune cell activation; the anti-inflammatory reflex arc is amiable to targeted stimulation as a therapeutic modality...
October 2016: Immunology Letters
https://www.readbyqxmd.com/read/27499876/genome-wide-analysis-reveals-conserved-transcriptional-responses-downstream-of-resting-potential-change-in-xenopus-embryos-axolotl-regeneration-and-human-mesenchymal-cell-differentiation
#18
Vaibhav P Pai, Christopher J Martyniuk, Karen Echeverri, Sarah Sundelacruz, David L Kaplan, Michael Levin
Endogenous bioelectric signaling via changes in cellular resting potential (V mem) is a key regulator of patterning during regeneration and embryogenesis in numerous model systems. Depolarization of V mem has been functionally implicated in dedifferentiation, tumorigenesis, anatomical re-specification, and appendage regeneration. However, no unbiased analyses have been performed to understand genome-wide transcriptional responses to V mem change in vivo. Moreover, it is unknown which genes or gene networks represent conserved targets of bioelectrical signaling across different patterning contexts and species...
February 2016: Regeneration
https://www.readbyqxmd.com/read/27428719/human-acellular-dermal-matrix-paired-with-silver-zinc-coupled-electroceutical-dressing-results-in-rapid-healing-of-complicated-diabetic-wounds-of-mixed-etiology-a-novel-case-series
#19
Windy Cole
Patients with diabetes are well known for having difficult-to-close wounds. When additional factors are added, such as gouty tophi or tumors, the difficulty is compounded and conventional care often fails to heal the wound. In this case series, an innovative wound modality that combined a human acellular dermal matrix with a silver-zinc coupled electroceutical wound dressing was used in 3 particularly difficult and complex cases. In all 3 cases, this alternative treatment provided full healing within 6 weeks in wounds that conventional care had been unable to close in up to 2 years...
July 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/27224508/functionalized-anatomical-models-for-em-neuron-interaction-modeling
#20
Esra Neufeld, Antonino Mario Cassará, Hazael Montanaro, Niels Kuster, Wolfgang Kainz
The understanding of interactions between electromagnetic (EM) fields and nerves are crucial in contexts ranging from therapeutic neurostimulation to low frequency EM exposure safety. To properly consider the impact of in vivo induced field inhomogeneity on non-linear neuronal dynamics, coupled EM-neuronal dynamics modeling is required. For that purpose, novel functionalized computable human phantoms have been developed. Their implementation and the systematic verification of the integrated anisotropic quasi-static EM solver and neuronal dynamics modeling functionality, based on the method of manufactured solutions and numerical reference data, is described...
June 21, 2016: Physics in Medicine and Biology
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