Qianyun Lin, Zitong Li, Lei Lu, Hua Xu, Eddie Lou, Alyssa Chen, Dustin Sun, Wuyi Zhang, Weishu Zhu, Eric U Yee, Pamela Suzanne Sears, Xinhua Chen, Ciaran P Kelly
BACKGROUND AND AIMS: Clostridioides difficile infection (CDI) induces intense acute inflammatory responses through toxin release. A combination of antibiotic and anti-inflammatory agents is sometimes recommended in severe, non-responsive cases, although clinical trials have been inconclusive, raising concerns about potential complications. This study aims to investigate the effect of budesonide and mesalamine in the treatment of CDI in a murine model, by evaluating the combination of fidaxomicin and these anti-inflammatory drugs...
September 13, 2023: Biomedicine & Pharmacotherapy