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https://www.readbyqxmd.com/read/29045942/quantitative-renal-echogenicity-as-a-tool-for-diagnosis-of-advanced-chronic-kidney-disease-in-patients-with-glomerulopathies-and-no-liver-disease
#1
Alexandre B Libório, Fernanda Macedo de Oliveira Neves, Candice Bezerra Torres de Melo, Tacyano Tavares Leite, Renata de Almeida Leitão
BACKGROUND/AIMS: Glomerulopathy patients are prone to developing transitory reduced glomerular filtration rate (GFR), which can be difficult to differentiate from irreversible chronic kidney disease (CKD). Renal ultrasound can be useful, but differently from renal length, quantitative renal echogenicity has not been formerly evaluated regarding its capacity to identify irreversible advanced CKD. METHODS: A prospective study was performed, where quantitative renal echogenicity was performed during renal biopsy in patients with suspected glomerular disease (n=197)...
October 18, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29045880/a-model-for-link-pruning-to-establish-correctly-polarized-and-oriented-tip-links-in-hair-bundles
#2
Nathan Tompkins, Kateri J Spinelli, Dongseok Choi, Peter G Barr-Gillespie
Tip links are thought to gate the mechanically sensitive transduction channels of hair cells, but how they form during development and regeneration remains mysterious. In particular, it is unclear how tip links are strung between stereocilia so that they are oriented parallel to a single axis; why their polarity is uniform despite their constituent molecules' intrinsic asymmetry; and why only a single tip link is present at each tip-link position. We present here a series of simple rules that reasonably explain why these phenomena occur...
October 17, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29045877/self-organization-of-ftsz-polymers-in-solution-reveals-spacer-role-of-the-disordered-c-terminal-tail
#3
Sonia Huecas, Erney Ramírez-Aportela, Albert Vergoñós, Rafael Núñez-Ramírez, Oscar Llorca, J Fernando Díaz, David Juan-Rodríguez, María A Oliva, Patricia Castellen, José M Andreu
FtsZ is a self-assembling GTPase that forms, below the inner membrane, the mid-cell Z-ring guiding bacterial division. FtsZ monomers polymerize head to tail forming tubulin-like dynamic protofilaments, whose organization in the Z-ring is an unresolved problem. Rather than forming a well-defined structure, FtsZ protofilaments laterally associate in vitro into polymorphic condensates typically imaged on surfaces. We describe here nanoscale self-organizing properties of FtsZ assemblies in solution that underlie Z-ring assembly, employing time-resolved x-ray scattering and cryo-electron microscopy...
October 17, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29045749/immune-checkpoint-inhibitor-related-myocarditis
#4
Kazuko Tajiri, Kazutaka Aonuma, Ikuo Sekine
Immune checkpoint inhibitors have demonstrated significant clinical benefit in many cancers. The clinical benefit afforded by these treatments can be accompanied by a unique and distinct spectrum of adverse events. Recently, several fatal cases of immune checkpoint inhibitor-related myocarditis were reported. Although its frequency is comparatively lower than that of other immune-related adverse events, myocarditis can lead to circulatory collapse and lethal ventricular arrhythmia. Immune checkpoints, cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1), play important roles in establishing peripheral tolerance to the heart...
October 17, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29045740/adding-vancomycin-to-perioperative-prophylaxis-decreases-deep-sternal-wound-infections-in-high-risk-cardiac-surgery-patients
#5
Sylvia Reineke, Thierry P Carrel, Verena Eigenmann, Brigitta Gahl, Urs Fuehrer, Christian Seidl, David Reineke, Eva Roost, Magi Bächli, Jonas Marschall, Lars Englberger
OBJECTIVES: Perioperative prophylaxis with cephalosporins reduces sternal wound infections (SWIs) after cardiac surgery. However, more than 50% of coagulase-negative staphylococci, an important pathogen, are cephalosporin resistant. The aim of this study was to determine the impact of adjunctive vancomycin on SWIs in high-risk patients. METHODS: We conducted a pre- and postintervention study in an academic hospital. Preintervention (2010-2011), all patients received prophylaxis with 1...
October 16, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29045651/clinical-decision-support-alert-malfunctions-analysis-and-empirically-derived-taxonomy
#6
Adam Wright, Angela Ai, Joan Ash, Jane F Wiesen, Thu-Trang T Hickman, Skye Aaron, Dustin McEvoy, Shane Borkowsky, Pavithra I Dissanayake, Peter Embi, William Galanter, Jeremy Harper, Steve Z Kassakian, Rachel Ramoni, Richard Schreiber, Anwar Sirajuddin, David W Bates, Dean F Sittig
Objective: To develop an empirically derived taxonomy of clinical decision support (CDS) alert malfunctions. Materials and Methods: We identified CDS alert malfunctions using a mix of qualitative and quantitative methods: (1) site visits with interviews of chief medical informatics officers, CDS developers, clinical leaders, and CDS end users; (2) surveys of chief medical informatics officers; (3) analysis of CDS firing rates; and (4) analysis of CDS overrides. We used a multi-round, manual, iterative card sort to develop a multi-axial, empirically derived taxonomy of CDS malfunctions...
October 16, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29045643/erratum-to-current-mid-term-outcome-with-an-integrated-surgical-strategy-for-correction-of-d-transposition-of-the-great-arteries-with-ventricular-septal-defect-and-left-ventricular-outflow-tract-obstruction-eur-j-cardiothorac-surg-2016-50-4-617-625-doi-10-1093
#7
Benjamin Bierbach, Claudia Arenz, Phillip Suchowerskyj, Sylvia Schroth, Jadwiga Blaschczok, Boulos Asfour, Martin Schneider, Viktor Hraška
No abstract text is available yet for this article.
October 17, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29045548/bold-activity-during-correct-answer-feedback-in-cued-recall-predicts-subsequent-retrieval-performance-an-fmri-investigation-using-a-partial-trial-design
#8
Adrian W Gilmore, Steven M Nelson, Farah Naaz, Ruth A Shaffer, Kathleen B McDermott
Receiving correct answer feedback following a retrieval attempt has proven to be a highly effective means of learning new information, yet the mechanisms behind its efficacy remain poorly understood. Here, fMRI was used to examine how BOLD activity measured during a period of feedback could predict subsequent memory (SM) performance on a final test. Twenty-five human subjects studied pairs of associated words, and were then asked to covertly recall target words in response to provided cues. Correct answer feedback was provided immediately after covert retrieval attempts...
October 17, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29045495/correction-pd-1-blockade-and-ox40-triggering-synergistically-protects-against-tumor-growth-in-a-murine-model-of-ovarian-cancer
#9
Zhiqiang Guo, Xin Wang, Dali Cheng, Zhijun Xia, Meng Luan, Shulan Zhang
[This corrects the article DOI: 10.1371/journal.pone.0089350.].
2017: PloS One
https://www.readbyqxmd.com/read/29045480/quantitative-assessment-of-finger-motor-performance-normative-data
#10
Alessio Signori, Maria Pia Sormani, Irene Schiavetti, Ambra Bisio, Marco Bove, Laura Bonzano
BACKGROUND: Finger opposition movements are the basis of many daily living activities and are essential in general for manipulating objects; an engineered glove quantitatively assessing motor performance during sequences of finger opposition movements has been shown to be useful to provide reliable measures of finger motor impairment, even subtle, in subjects affected by neurological diseases. However, the obtained behavioral parameters lack published reference values. OBJECTIVE: To determine mean values for different motor behavioral parameters describing the strategy adopted by healthy people in performing repeated sequences of finger opposition movements, examining associations with gender and age...
2017: PloS One
https://www.readbyqxmd.com/read/29045475/association-between-rna-binding-protein-ptbp2-and-germ-cell-injury-in-an-experimentally-induced-unilateral-cryptorchidism-murine-model
#11
Xianming Dou, Jingjing Gao, Pan Gao, Dongdong Tang, Dangwei Peng, Jun Mao, Zhenyu Huang, Peng Chen, He Chen, Shengwei Ke, Chaozhao Liang, Xiansheng Zhang
RNA binding protein polypyrimidine tract binding protein 2 (Ptbp2) as a key alternative splicing regulator for male germ cell development is well established. However, its expression levels and role in cryptorchidism testes tissues has not been explored. Additionally, the molecular mechanism of heat stress impacts the correct proliferation and differentiation of germ cells is unclear. To investigate whether changes in Ptbp2 expression are correlated with heat stress-induced germ cell injury in testicular tissue, we used a murine model of intraperitoneal cryptorchidism with surgical operation...
2017: PloS One
https://www.readbyqxmd.com/read/29045462/correction-temporal-causal-inference-with-stochastic-audiovisual-sequences
#12
Shannon M Locke, Michael S Landy
[This corrects the article DOI: 10.1371/journal.pone.0183776.].
2017: PloS One
https://www.readbyqxmd.com/read/29045407/bayesian-refinement-of-protein-structures-and-ensembles-against-saxs-data-using-molecular-dynamics
#13
Roman Shevchuk, Jochen S Hub
Small-angle X-ray scattering is an increasingly popular technique used to detect protein structures and ensembles in solution. However, the refinement of structures and ensembles against SAXS data is often ambiguous due to the low information content of SAXS data, unknown systematic errors, and unknown scattering contributions from the solvent. We offer a solution to such problems by combining Bayesian inference with all-atom molecular dynamics simulations and explicit-solvent SAXS calculations. The Bayesian formulation correctly weights the SAXS data versus prior physical knowledge, it quantifies the precision or ambiguity of fitted structures and ensembles, and it accounts for unknown systematic errors due to poor buffer matching...
October 18, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29045399/correction-comparative-transcriptomes-of-adenocarcinomas-and-squamous-cell-carcinomas-reveal-molecular-similarities-that-span-classical-anatomic-boundaries
#14
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pgen.1006938.].
October 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29045358/evaluating-the-rotation-correction-of-the-main-thoracic-curve-in-severe-adolescent-idiopathic-scoliosis-bending-and-traction-vs-fulcrum-a-preliminary-report
#15
Qing-Jie Kong, Xiao-Fei Sun, Yuan Wang, Jing-Chuan Sun, Zi-Qiang Chen, Yong Yang, Jian-Gang Shi
BACKGROUND Flexibility evaluation methods were only used to assess the changes of coronal Cobb angle in patients with adolescent idiopathic scoliosis (AIS). Little attention was attached to the vertebral rotation in these methods. MATERIAL AND METHODS 21 patients with severe adolescent idiopathic scoliosis were enrolled in this study. Coronal flexibility and rotation correction were compared on the supine bending, traction and fulcrum bending radiographs. The apical vertebral body rib ratio (AVB-R), and Perdriolle rotation angles were used to measure the rotation of the main thoracic curve...
October 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29045356/addressing-safe-opioid-monitoring-practices-using-an-interprofessional-approach
#16
Marianne L Durham, AnnMarie Egan, Ann Jankiewicz, Marcia P Murphy, Patricia Nedved, Renee Luvich, Ann Goh, Louis Fogg
OBJECTIVE: The aims of the project are to increase knowledge related to opioids and improve adherence to evidence-based interventions for sedation monitoring and assessment in adult inpatients receiving opioids for pain through delivery of an interprofessional online program. BACKGROUND: Preventable opioid-induced respiratory depression is a patient safety risk in hospitals. Sedation and respiratory assessment and monitoring guidelines and tools are available to improve practice...
October 17, 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29045253/gut-microbial-diversity-in-hiv-infection-post-combined-antiretroviral-therapy-a-key-target-for-prevention-of-cardiovascular-disease
#17
Mohamed El-Far, Cécile L Tremblay
PURPOSE OF REVIEW: Although the HIV-infected population is living longer and getting older under current treatment regimens, significant challenges arise for health management as the infection is associated with various premature aging phenotypes, particularly increased incidence of cardiovascular diseases (CVDs). Here we review the current understanding of HIV-related gut dysbiosis in association with CVD and advances in clinical trials aiming to restore gut microbial diversity. RECENT FINDING: Identification of a unique signature for gut dysbiosis in HIV infection between different cohorts remains challenging...
October 17, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29045130/correction-to-selective-targeting-by-a-mechanism-based-inactivator-against-pyridoxal-5-phosphate-dependent-enzymes-mechanisms-of-inactivation-and-alternative-turnover
#18
Romila Mascarenhas, Hoang V Le, Kenneth D Clevenger, Helaina J Lehrer, Dagmar Ringe, Neil L Kelleher, Richard B Silverman, Dali Liu
No abstract text is available yet for this article.
October 18, 2017: Biochemistry
https://www.readbyqxmd.com/read/29045078/skin-tears-and-risk-factors-assessment-a-systematic-review-on-evidence-based-medicine
#19
Raffaele Serra, Nicola Ielapi, Andrea Barbetta, Stefano de Franciscis
Skin tears represent a common condition of traumatic wounds, which may be encountered in some categories of individuals at the extremes of age, such as infants and the elderly. Despite the high prevalence and cost of these lesions, there has been little investigation into the risk factors that lead to this condition. The aim of this review was to systematically evaluate the main risk factors involved in development of skin tears. We planned to include all the studies dealing with risk factors related to skin tears...
October 17, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29044988/age-associated-microrna-expression-in-human-peripheral-blood-is-associated-with-all-cause-mortality-and-age-related-traits
#20
Tianxiao Huan, George Chen, Chunyu Liu, Anindya Bhattacharya, Jian Rong, Brian H Chen, Sudha Seshadri, Kahraman Tanriverdi, Jane E Freedman, Martin G Larson, Joanne M Murabito, Daniel Levy
Recent studies provide evidence of correlations of DNA methylation and expression of protein-coding genes with human aging. The relations of microRNA expression with age and age-related clinical outcomes have not been characterized thoroughly. We explored associations of age with whole-blood microRNA expression in 5221 adults and identified 127 microRNAs that were differentially expressed by age at P < 3.3 × 10(-4) (Bonferroni-corrected). Most microRNAs were underexpressed in older individuals. Integrative analysis of microRNA and mRNA expression revealed changes in age-associated mRNA expression possibly driven by age-associated microRNAs in pathways that involve RNA processing, translation, and immune function...
October 17, 2017: Aging Cell
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