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https://www.readbyqxmd.com/read/29456660/the-role-of-mir-766-5p-in-cell-migration-and-invasion-in-colorectal-cancer
#1
Bin Jia, Lei Xia, Fang Cao
Colorectal cancer (CRC) develops from the colon or rectum and is the fourth highest inducer of cancer mortality. In the present study, cancer tissues and normal tissues were extracted from patients with CRC who were treated in the Affiliated Hospital of Shandong University of Traditional Chinese Medicine (Jinan, China). Reverse transcription-quantitative polymerase chain reaction demonstrated that the expression level of miR-766-5p was significantly higher (P<0.01) in cancer tissue than that in normal tissue...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456091/frequency-of-human-papillomavirus-infection-in-patients-with-gastrointestinal-cancer
#2
F Roesch-Dietlen, A D Cano-Contreras, Y J Sánchez-Maza, J M Espinosa-González, M Á Vázquez-Prieto, E J Valdés-de la O, F Díaz-Roesch, M Á Carrasco-Arroniz, A Cruz-Palacios, P Grube-Pagola, A Sumoza-Toledo, H Vivanco-Cid, G Mellado-Sánchez, A Meixueiro-Daza, C S Silva-Cañetas, M G Carrillo-Toledo, R Lagunes-Torres, M Amieva-Balmori, P C Gómez-Castaño, J U Reyes-Huerta, J M Remes-Troche
INTRODUCTION AND AIM: Cancer is the result of the interaction of genetic and environmental factors. It has recently been related to viral infections, one of which is human papillomavirus. The aim of the present study was to describe the frequency of human papillomavirus infection in patients with digestive system cancers. MATERIALS AND METHODS: A prospective, multicenter, observational study was conducted on patients with gastrointestinal cancer at 2public healthcare institutes in Veracruz...
February 15, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29454572/presence-of-colon-carcinoma-cells-at-the-resection-line-may-cause-recurrence-following-stapling-anastomosis
#3
Tzu-Chi Hsu, Ming-Jen Chen
BACKGROUND/OBJECTIVE: The presence of carcinoma cells in the suture line may result in local recurrence. The purpose of this study was to assess whether carcinoma cells were present along the resection line where the distal clamp was applied. METHODS: During surgery, the rectum was clamped at least 3 cm distal to the palpable margin of the tumor mass. The rectum was divided distal and proximal to the clamp. The tissue inside the clamp was rinsed with normal saline, and the irrigation solution was sent for cytologic examination...
February 14, 2018: Asian Journal of Surgery
https://www.readbyqxmd.com/read/29454571/feasibility-of-restorative-proctocolectomy-in-patients-with-ulcerative-colitis-associated-lower-rectal-cancer-a-retrospective-study
#4
Shinnosuke Hotta, Yoshifumi Shimada, Mae Nakano, Saki Yamada, Kaoru Abe, Hidehito Oyanagi, Ryoma Yagi, Yosuke Tajima, Masato Nakano, Hitoshi Kameyama, Masayuki Nagahashi, Jun Sakata, Takashi Kobayashi, Toshifumi Wakai
BACKGROUND/OBJECTIVE: Restorative proctocolectomy (RP) may improve quality of life in patients with ulcerative colitis (UC)-associated lower rectal cancer to a greater extent than total proctocolectomy. However, patients with UC-associated cancer often have flat mucosal lesions that make it extremely difficult to endoscopically delineate the tumor margins. Therefore, there is a potential risk of residual tumor and local recurrence after RP in patients with UC-associated lower rectal cancer...
February 14, 2018: Asian Journal of Surgery
https://www.readbyqxmd.com/read/29445866/second-primary-colorectal-cancer-among-endometrial-cancer-survivor-shared-etiology-and-treatment-sequelae
#5
Myong Cheol Lim, Young-Joo Won, Jiwon Lim, Sang-Soo Seo, Sokbom Kang, Chong Woo Yoo, Joo-Young Kim, Jae Hwan Oh, Robert E Bristow, Sang-Yoon Park
PURPOSE: To evaluate the incidence of colon cancer as a second primary cancer (CCSPC) and the survival outcomes of women with and without CCSPC after the diagnosis of endometrial cancer (EC). METHODS: The standardized incidence ratio (SIR) of CCSPC and survival outcomes of EC survivors with and without CCSPC were analyzed using data from January 1 1993 to December 31 2011, obtained from the Korea Central Cancer Registry. RESULTS: Of 14,797 EC survivors, 147 (0...
February 14, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29445855/-treatment-strategy-for-early-stage-rectal-cancer-t1-carcinoma
#6
REVIEW
G Liebig-Hörl, C Puchner, M Gerken, M Klinkhammer-Schalke, A Fürst
BACKROUND: A common consensus for the definition for early rectal cancer does not exist. This item is used in cases of histological findings including pTis, pT1 or pT2 tumors. The term early rectal cancer is not mentioned in the German S3 guidelines on colorectal cancer. The pTis tumors are located at the mucosa level of the intestinal wall and they have nearly no tendency to develop metastases but pT2 tumors have a high risk of local metastases; therefore, the term early rectal cancer is not adequate for pT2 tumors...
February 14, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29442059/modified-transverse-coloplasty-pouch-new-reconstruction-techniques-after-total-mesorectal-excision-our-experience
#7
G Grimaldi, Chiara Eberspacher, A M Romani, D Merletti, A Maturo, S Pontone, D Pironi
AIM: The incidence of rectal cancer continues to rise. The functional results after complete Total Mesorectal Excision (TME) depend on the segment of colon used for reconstruction of colonic continuity and the form, the volume and the functional proprieties of the "neorectum". The aim of our study is evaluate the efficacy of our Modified Transverse Coloplasty Pouch (MTCP) after the treatment of low rectal cancer in terms of functional outcomes and quality of life. PATIENTS AND METHODS: The study included 136 patients, underwent TME from January 2007 to December 2016 with diagnosis of extraperitoneal carcinoma of the rectum...
November 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29441419/modern-intensity-modulated-radiotherapy-with-image-guidance-allows-low-toxicity-rates-and-good-local-control-in-chemoradiotherapy-for-anal-cancer-patients
#8
Berardino De Bari, Laëtitia Lestrade, Alessandra Franzetti-Pellanda, Raphael Jumeau, Maira Biggiogero, Melpomeni Kountouri, Oscar Matzinger, Raymond Miralbell, Jean Bourhis, Mahmut Ozsahin, Thomas Zilli
PURPOSE: To report outcomes of a population of anal cancer patients treated with modern intensity-modulated radiotherapy and daily image-guided radiotherapy techniques. METHODS: We analyzed data of 155 patients consecutively treated with intensity-modulated radiotherapy +/- chemotherapy in three radiotherapy departments. One hundred twenty-two patients presented a stage II-IIIA disease. Chemotherapy was administered in 138 patients, mainly using mitomycin C and 5-fluorouracil (n = 81)...
February 13, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29439826/radiation-induced-leiomyosarcoma-of-the-rectum-after-cervical-cancer-treatment
#9
D Y Garcia-Ortega, N Reyes-Garcia, H Martinez-Said, C H S Caro-Sanchez, M Cuellar-Hubbe
No abstract text is available yet for this article.
February 10, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29438375/telomere-length-and-genetics-are-independent-colorectal-tumour-risk-factors-in-an-evaluation-of-biomarkers-in-normal-bowel
#10
Ceres Fernandez-Rozadilla, Christiana Kartsonaki, Connor Woolley, Michael McClellan, Deb Whittington, Gareth Horgan, Simon Leedham, Skirmantas Kriaucionis, James East, Ian Tomlinson
BACKGROUND: Colorectal cancer (CRC) screening might be improved by using a measure of prior risk to modulate screening intensity or the faecal immunochemical test threshold. Intermediate molecular biomarkers could aid risk prediction by capturing both known and unknown risk factors. METHODS: We sampled normal bowel mucosa from the proximal colon, distal colon and rectum of 317 individuals undergoing colonoscopy. We defined cases as having a personal history of colorectal polyp(s)/cancer, and controls as having no history of colorectal neoplasia...
February 13, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29435742/information-needs-expressed-during-patient-oriented-oncology-consultations-quantity-variation-and-barriers
#11
Anesa Ahamad, Paul Wallner, Sharon Salenius, Rudi Ross, Eduardo Fernandez
High-quality oncology consultation includes patient-oriented communication tailored to patients' individualized needs. Common methods used in studies to increase question-asking are prompt lists and coaching pre-consultations. However, our patients were encouraged to ask questions by the physician during their visit. We aimed to estimate the quantity, nature, and variation of their questions when they were invited to ask by their oncologist. During radiotherapy consultations from 2012 to 2016, patient's questions were deliberately elicited and physician-transcribed...
February 12, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29434964/lymph-node-retrieval-after-dissolution-of-surrounding-adipose-tissue-for-pathological-examination-of-colorectal-cancer
#12
Hiromichi Maeda, Ken Okamoto, Koji Oba, Mai Shiga, Yuki Fujieda, Tsutomu Namikawa, Makoto Hiroi, Ichiro Murakami, Kazuhiro Hanazaki, Michiya Kobayashi
Examination of >12 lymph nodes (LNs) is important for the diagnostic accuracy of nodal status following resection of colorectal cancer. In the present study, the efficacy of a fat dissolution technique for LN retrieval was evaluated using resected colon and rectum mesentery. First, the resected mesentery was searched for LNs by inspection and palpation immediately after surgery. Subsequently, fat dissolution liquid was applied to the remnant fat and the LN search was repeated. The primary endpoint was whether the second assessment would increase the number of evaluated LNs...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29428473/urinary-dysfunction-after-rectal-cancer-surgery-results-from-a-randomized-trial-comparing-mesorectal-excision-with-and-without-lateral-lymph-node-dissection-for-clinical-stage-ii-or-iii-lower-rectal-cancer-japan-clinical-oncology-group-study-jcog0212
#13
Masaaki Ito, Akihiro Kobayashi, Shin Fujita, Junki Mizusawa, Yukihide Kanemitsu, Yusuke Kinugasa, Koji Komori, Masayuki Ohue, Mitsuyoshi Ota, Yoshihiro Akazai, Manabu Shiozawa, Takashi Yamaguchi, Takayuki Akasu, Yoshihiro Moriya
BACKGROUND: Postoperative urinary dysfunction is a major complication of rectal cancer surgery. A randomized controlled trial (JCOG0212) concluded that the noninferiority of mesorectal excision alone to mesorectal excision with lateral lymph node dissection was not confirmed in terms of relapse-free survival. METHODS: Eligibility criteria included histologically proven clinical stage II/III rectal cancer, a main lesion located in the rectum with the lower margin below the peritoneal reflection, and the absence of lateral lymph node enlargement...
January 17, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29426744/improving-dose-delivery-by-adding-interstitial-catheters-to-fixed-geometry-applicators-in-high-dose-rate-brachytherapy-for-cervical-cancer
#14
Sophie Otter, Amanda Coates, Adrian Franklin, Melanie Cunningham, Alexandra Stewart
PURPOSE: Image-guided brachytherapy (IGBT) is an essential component of the treatment of locally advanced cervical cancer. Interstitial (IS) catheters are being increasingly used for bulkier tumors. We have retrospectively assessed the dosimetric impact of IS catheters. METHODS AND MATERIALS: All patients who received IGBT for cervical cancer between August 2014 and February 2017 were identified. Clinical and dosimetric data were collected. Patients were grouped into the intracavitary (IC) cohort or the IC and IS implant (IC/IS) cohort...
February 6, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29426638/comparison-of-dosimetric-parameters-derived-from-whole-organ-and-wall-contours-for-bladder-and-rectum-in-cervical-cancer-patients-treated-with-intracavitary-and-interstitial-brachytherapy
#15
Rachel Gerber, Alexandra Rink, Jennifer Croke, Jette Borg, Akbar Beiki-Ardakani, Anthony Fyles, Michael Milosevic, Jason Xie, Harald Keller, Kathy Han
For volumes up to 2 cm3 of the bladder and possibly up to 5 cm3 of the rectum, doses computed from the whole organ were good estimates of the doses in the wall in cervix brachytherapy, and there were no significant differences between patients treated with or without interstitial needles.
February 6, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29423501/association-of-sulindac-and-erlotinib-vs-placebo-with-colorectal-neoplasia-in-familial-adenomatous-polyposis-secondary-analysis-of-a-randomized-clinical-trial
#16
N Jewel Samadder, Scott K Kuwada, Kenneth M Boucher, Kathryn Byrne, Priyanka Kanth, Wade Samowitz, David Jones, Sean V Tavtigian, Michelle Westover, Therese Berry, Kory Jasperson, Lisa Pappas, Laurel Smith, Danielle Sample, Randall W Burt, Deborah W Neklason
Importance: Patients with familial adenomatous polyposis (FAP) are at markedly increased risk for colorectal polyps and cancer. A combination of sulindac and erlotinib led to a 71% reduction in duodenal polyp burden in a phase 2 trial. Objective: To evaluate effect of sulindac and erlotinib on colorectal adenoma regression in patients with FAP. Design, Setting, and Participants: Prespecified secondary analysis for colorectal adenoma regression was carried out using data from a double-blind, randomized, placebo-controlled trial, enrolling 92 patients with FAP, conducted from July 2010 to June 2014 in Salt Lake City, Utah...
February 8, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29414633/the-impact-of-rectal-cancer-tumor-height-on-recurrence-rates-and-metastatic-location-a-competing-risk-analysis-of-a-national-database
#17
Knut M Augestad, Deborah S Keller, Paul M Bakaki, Johnie Rose, Siran M Koroukian, Tom Øresland, Conor P Delaney
BACKGROUND: The impact of rectal cancer tumor height on local recurrence and metastatic spread is unknown. The objective was to evaluate the impact of rectal cancer tumor height from the anal verge on metastatic spread and local recurrence patterns. METHODS: The Norwegian nationwide surgical quality registry was reviewed for curative rectal cancer resections from 1/1/1996-12/15/2006. Cancers were stratified into five height groups: 0-3 cm, >3-5 cm, >5-9 cm, >9-12 cm, 12 cm-HI...
January 30, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29413211/gastrointestinal-traumatic-injuries-gastrointestinal-perforation
#18
REVIEW
Maria A Revell, Marcia A Pugh, Melanie McGhee
The abdomen is a big place even in a small person. Gastrointestinal trauma can result in injury to the stomach, small bowel, colon, or rectum. Traumatic causes include blunt or penetrating trauma, such as gunshot wounds, stabbings, motor vehicle collisions, and crush injuries. Nontraumatic causes include appendicitis, Crohn disease, cancer, diverticulitis, ulcerative colitis, blockage of the bowel, and chemotherapy. The mechanism of injury will affect both the nature and severity of any resulting injuries. Treatment must address the critical and emergent nature of these injuries as well as issues that affect all trauma situations, which include management of hemodynamic instability...
March 2018: Critical Care Nursing Clinics of North America
https://www.readbyqxmd.com/read/29409457/the-potential-predictive-value-of-dek-expression-for-neoadjuvant-chemoradiotherapy-response-in-locally-advanced-rectal-cancer
#19
J Martinez-Useros, I Moreno, M J Fernandez-Aceñero, M Rodriguez-Remirez, A Borrero-Palacios, A Cebrian, T Gomez Del Pulgar, L Del Puerto-Nevado, W Li, A Puime-Otin, N Perez, M S Soengas, J Garcia-Foncillas
BACKGROUND: Limited data are available regarding the ability of biomarkers to predict complete pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. Complete response translates to better patient survival. DEK is a transcription factor involved not only in development and progression of different types of cancer, but is also associated with treatment response. This study aims to analyze the role of DEK in complete pathological response following chemoradiotherapy for locally advanced rectal cancer...
February 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29402298/laparoscopic-low-anterior-resection-for-rectal-cancer-with-rectal-prolapse-a-case-report
#20
Ryusei Yamamoto, Yasuji Mokuno, Hideo Matsubara, Hirokazu Kaneko, Shinsuke Iyomasa
BACKGROUND: Rectal cancer with rectal prolapse is rare, described by only a few case reports. Recently, laparoscopic surgery has become standard procedure for either rectal cancer or rectal prolapse. However, the use of laparoscopic low anterior resection for rectal cancer with rectal prolapse has not been reported. CASE PRESENTATION: A 63-year-old Japanese woman suffered from rectal prolapse, with a mass and rectal bleeding for 2 years. An examination revealed complete rectal prolapse and the presence of a soft tumor, 7 cm in diameter; the distance from the anal verge to the tumor was 5 cm...
February 6, 2018: Journal of Medical Case Reports
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