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Cancer of the rectum

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https://www.readbyqxmd.com/read/29675592/late-assessment-of-quality-of-life-in-patients-with-rectal-carcinoma-comparison-between-sphincter-preservation-and-definitive-colostomy
#1
Mariane Messias Reis Lima Silva, Samuel Aguiar Junior, Juliana de Aguiar Pastore, Érica Maria Monteiro Santos, Fábio de Oliveira Ferreira, Ranyell Matheus S B Spencer, Vinicius F Calsavara, Wilson Toshihiko Nakagawa, Ademar Lopes
PURPOSE: Patients with cancer of the lower and middle rectum who are candidates for curative surgery often have negative opinions on definitive colostomy. The purpose of this study is to compare the quality of life (QoL) of patients who undergo standard treatment for rectal cancer with sphincter preservation or definitive colostomy. METHODS: A total of 125 patients with adenocarcinoma of the lower or middle rectum who underwent radical surgery with curative intent with a follow-up ≥ 1 year were recruited: 83 patients (group 1) were subjected to low anterior resection and low colorectal or coloanal anastomosis-thus preserving their sphincter-and 42 (group 2) were treated with abdominoperineal resection, followed by terminal definitive colostomy...
April 19, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29672814/-long-term-survival-of-patients-with-colon-and-rectum-carcinomas-is-there-a-difference-between-cancer-centers-and-non-certified-hospitals
#2
Vinzenz Völkel, Teresa Draeger, Michael Gerken, Alois Fürst, Monika Klinkhammer-Schalke
AIM OF THE STUDY: Hospitals specializing in the treatment of colorectal carcinoma with high quality standards can apply for certification as colorectal cancer centers. The aim of this study was to clarify if there is a substantial difference between certified and non-certified hospitals in terms of long-term survival of patients. METHODS: This is a population-based retrospective cohort study using the data of a clinical cancer registry (Tumorzentrum Regensburg) which covers a southern German region of approximately 1...
April 19, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29667174/impact-of-prior-cancer-history-on-the-overall-survival-of-patients-newly-diagnosed-with-cancer-a-pan-cancer-analysis-of-the-seer-database
#3
Huaqiang Zhou, Yan Huang, Zeting Qiu, Hongyun Zhao, Wenfeng Fang, Yunpeng Yang, Yuanyuan Zhao, Xue Hou, Yuxiang Ma, Shaodong Hong, Ting Zhou, Yaxiong Zhang, Li Zhang
The population of cancer survivors with prior cancer is rapidly growing. Whether a prior cancer diagnosis interferes with outcome is unknown. We conducted a pan-cancer analysis to determine the impact of prior cancer history for patients newly diagnosed with cancer. We identified 20 types of primary solid tumors between 2004 to 2008 in the Surveillance, Epidemiology, and End Results (SEER) database. Demographic and clinicopathologic variables were compared by chi-squared test and t-test as appropriate. The propensity score-adjusted Kaplan-Meier method and Cox proportional hazards models were used to evaluate the impact of prior cancer on overall survival (OS)...
April 18, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29665832/volumetric-and-dosimetric-comparison-of-organs-at-risk-between-the-prone-and-supine-positions-in-postoperative-radiotherapy-for-prostate-cancer
#4
Subaru Sawayanagi, Hideomi Yamashita, Mami Ogita, Tomoki Kiritoshi, Takahiro Nakamoto, Osamu Abe, Keiichi Nakagawa
BACKGROUND: The aim of this study was to evaluate the effects of patient positioning on the volume of organs at risk (OARs) in or near the planning target volume (PTV) and the dose distribution in adjuvant or salvage radiotherapy for prostate cancer after prostatectomy. METHODS: Seventeen patients who received intensity-modulated radiation therapy (66 Gy in 33 fractions) as adjuvant or salvage therapy after prostatectomy were evaluated. All patients underwent CT scans in both the prone (on a belly board) and supine positions...
April 17, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29663417/technical-note-a-deep-learning-based-auto-segmentation-of-rectal-tumors-in-mr-images
#5
Jiazhou Wang, Jiayu Lu, Gan Qin, Lijun Shen, Yiqun Sun, Hongmei Ying, Zhen Zhang, Weigang Hu
PURPOSE: Manual contouring of gross tumor volumes (GTV) is a crucial and time-consuming process in rectum cancer radiotherapy. This study aims to develop a simple deep learning based auto segmentation algorithm to segment rectal tumors on T2 weighted MR images. MATERIAL AND METHODS: MRI scans (3T, T2-weighted) of 93 patients with locally advanced (cT3-4 and/or cN1-2) rectal cancer treated with neoadjuvant chemoradiotherapy followed by surgery were enrolled in this study...
April 16, 2018: Medical Physics
https://www.readbyqxmd.com/read/29662622/quantitative-parameters-in-dynamic-contrast-enhanced-magnetic-resonance-imaging-for-the-detection-and-characterization-of-prostate-cancer
#6
Cheng Wei, Bowen Jin, Magdalena Szewczyk-Bieda, Stephen Gandy, Stephen Lang, Yilong Zhang, Zhihong Huang, Ghulam Nabi
Objectives: to assess the diagnostic accuracy of quantitative parameters of DCE-MRI in multi-parametric MRI (mpMRI) in comparison to the histopathology (including Gleason grade) of prostate cancer. Patients and methods: 150 men with suspected prostate cancer (abnormal digital rectum examination and or elevated prostate-specific antigen) received pre-biopsy 3T mpMRI and were recruited into peer-reviewed, protocol-based prospective study. The DCE-MRI quantitative parameters ( Ktrans (influx transfer constant) and kep (efflux rate constant)) of the cancerous and normal areas were recorded using four different kinetic models employing Olea Sphere (Olea Medical, La Ciotat, France)...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29662560/impact-of-68-ga-dota-peptide-pet-ct-on-the-management-of-gastrointestinal-neuroendocrine-tumour-gi-net-malaysian-national-referral-centre-experience
#7
Teik Hin Tan, Ching Yeen Boey, Boon Nang Lee
Purpose: The National Cancer Institute is the only referral centre in Malaysia that provides 68 Ga-DOTA-peptide imaging. The purpose of this study is to determine the impact of 68 Ga-DOTA-peptide PET/CT on the management of gastrointestinal neuroendocrine tumours (GI-NET). Materials and Methods: A cross-sectional study was performed to review the impact of 68 Ga-DOTA-peptide (68 Ga-DOTATATE or 68 Ga-DOTATOC) PET/CT on patients with biopsy-proven GI-NET between January 2011 and December 2015...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29661621/predictive-nomogram-for-recurrence-of-stage-i-colorectal-cancer-after-curative-resection
#8
Chan Kim, Woo Ram Kim, Ki-Yeol Kim, Hong Jae Chon, Seung Hoon Beom, Hyojoong Kim, Minkyu Jung, Sang Joon Shin, Nam Kyu Kim, Joong Bae Ahn
BACKGROUND: Patients with stage I colorectal cancer (CRC) have excellent prognosis after curative surgery. However, approximately 5% to 10% of patients experience recurrence and have a poor prognosis. Because the incidence of stage I CRC is increasing with active screening programs worldwide, a more accurate and easy-to-use predictive tool for recurrence is becoming more important. This study aimed to develop a predictive nomogram for recurrence in stage I CRC. PATIENTS AND METHODS: A total of 1538 patients who underwent curative surgery for stage I CRC were enrolled...
March 29, 2018: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29661177/loss-of-zg16-is-associated-with-molecular-and-clinicopathological-phenotypes-of-colorectal-cancer
#9
Hui Meng, Wencai Li, Lisa A Boardman, Liang Wang
BACKGROUND: Zymogen granule protein 16 (ZG16) is one of the most significantly down-regulated genes in colorectal cancer (CRC) tissues. This study aimed to further evaluate its expression changes and investigate its association with molecular and clinicopathological characteristics of CRC. METHODS: We applied quantitative RT-PCR to determine expression difference between tumor and matched normal tissues from 23 CRC patients. To further validate the down-regulation in tumor tissues, we performed immunohistochemistry (IHC) analysis in 40 paraffin-embedded normal-tumor pairs and 22 colon tissues with a variety of diseases...
April 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29660527/the-association-between-mutations-in-braf-and-colorectal-cancer-specific-survival-depends-on-microsatellite-status-and-tumor-stage
#10
Hendrik Bläker, Elizabeth Alwers, Alexander Arnold, Esther Herpel, Katrin E Tagscherer, Wilfried Roth, Lina Jansen, Viola Walter, Matthias Kloor, Jenny Chang-Claude, Hermann Brenner, Michael Hoffmeister
BACKGROUND & AIMS: Colorectal tumors with mutations in BRAF and microsatellite stability (MSS) have been associated with adverse outcomes of patients. Combined tests for microsatellite instability (MSI-H) and BRAF mutations might therefore be used in risk assessment, particularly for patients with stage II tumors. We investigate the stage-specific prognostic value of combined testing for MSI-H and BRAF for patients with colorectal cancer (CRC). METHODS: We performed a retrospective analysis of colorectal tumor samples collected from 1995 patients at 22 hospitals in Germany, between 2003 and 2010...
April 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29658680/rectal-cancer-and-the-pathologist
#11
Mariana Berho, Pablo A Bejarano
INTRODUCTION: Examination of the rectum by pathologists is instrumental in the management of patients affected by rectal carcinoma. That role includes evaluation of multiple gross and microscopic features that convey prognostic implications. EVIDENCE ACQUISITION: The analysis is based on the authors' experience handling rectal specimens along with review of the pertinent literature in these areas: margins of excision, quality of the mesorectum, diligence and techniques to sample lymph nodes, tumor budding, grading of residual amount of carcinoma after pre-operative therapy, vascular/perineural invasion, and staging the tumor...
April 13, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29656304/the-gentamicin-collagen-implant-and-the-risk-of-distant-metastases-of-rectal-cancer-following-short-course-radiotherapy-and-curative-resection-the-long-term-outcomes-of-a-randomized-study
#12
Andrzej Rutkowski, Lucyna Pietrzak, Jacek Kryński, Leszek Zając, Mariusz Bednarczyk, Tomasz Olesiński, Marek Szpakowski, Piotr Saramak, Ireneusz Pierzankowski, Piotr Hevelke, Piotr Surowski, Krzysztof Bujko
PURPOSE: A previous randomized study conducted by our group showed that application of gentamicin-collagen implant (GCI) into the pelvic cavity after total mesorectal excision (TME) reduced the incidence of distant metastases. Therefore, we decided to conduct a confirmatory study. METHODS: Patients with rectal cancer were included in the study if they met the following criteria: adenocarcinoma of the rectum, preoperative short-term radiotherapy (5 × 5 Gy), and WHO performance score 0-1...
April 15, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29651788/sphincter-preserving-surgery-for-recurrent-pelvic-malignancy-using-a-hybrid-procedure-of-open-laparotomy-and-transanal-endoscopic-approach
#13
Seiji Ishiguro, Shunichiro Komatsu, Kenichi Komaya, Takuya Saito, Takashi Arikawa, Kenichiro Kaneko, Tsuyoshi Sano
BACKGROUND: Surgery for the treatment of recurrent pelvic malignancy is challenging. Sphincter-preserving surgery (SPS) has been applied in limited cases. Transanal endoscopic approach (TEA) has been used for primary rectal cancer, predominantly for hybrid transabdominal-transanal total mesorectal excision. Here, we describe the use of TEA as a hybrid approach in a case of recurrent ovarian cancer. CASE PRESENTATION: A 59-year-old woman had recurrence of serous ovarian adenocarcinoma in the vaginal stump, near the site of anastomosis from a rectal resection 18 months previously...
April 12, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29651671/are-endometrial-cancer-radiotherapy-results-age-related
#14
Á Rovirosa, K S Cortés, C Ascaso, A Glickman, S Valdés, A Herreros, C Camacho, J Sánchez, Y Zhang, Y Li, S Sabater, M Arenas, A Torne
OBJECTIVE: To analyze the impact of age on radiotherapy results based on cancer-specific survival (CSS), vaginal-cuff relapses (VCR) and complications analysis in 438 patients with endometrial carcinoma (EC) receiving postoperative radiotherapy (PRT) divided into three age groups for analysis. MATERIALS AND METHODS: From 2003 to 2015, 438 patients with EC were treated with PRT and divided into three age groups: Group-1: 202 patients < 65 years; Group-2: 210 patients ≥ 65 and < 80 years; Group-3: 26 patients ≥ 80 years...
April 12, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29650925/-a-case-of-colon-cancer-with-brain-liver-and-lung-metastasis-successfully-treated-with-bevacizumab-plus-xelox-therapy
#15
Tomokazu Tokoro, Keishi Nakamura, Atsushi Hirose, Shinichi Nakanuma, Kohichi Okamoto, Jun Kinoshita, Isamu Makino, Hironori Hayashi, Katsunobu Oyama, Tomoharu Miyashita, Hidehiro Tajima, Hiroyuki Takamura, Itasu Ninomiya, Sachio Fushida, Tetsuo Ohta
The patient was a 57-year-old woman. Preclinical examination of malignant lymphoma revealed 0-I sp type of early rectal cancer in the upper rectum, 20 cm from the anal margin. Endoscopic mucosal resection was performed and positive deep margins were pathologically diagnosed. Additional intestinal resection with lymph node dissection was deemed necessary, but ABVD therapy was initiated because the clinical stage of the malignant lymphoma was Stage III b or higher. Two months after detecting elevated CEA, S8 liver metastasis was pointed out, and examination of weakness of the right upper limb revealed nodular, multifocal brain metastasis...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650909/-endoscopic-topical-therapy-using-mesh-for-refractory-suture-failure-after-rectal-cancer-surgery
#16
Yukika Tsukamoto, Hisami Oshima, Takashi Katsumori, Hiromitsu Hamaguchi, Shinichi Yamamoto, Tomohiro Iwanaga, Susumu Ohkawara
We reported a case that could be cured with endoscopic topical therapyusing mesh for refractorysuture failure after rectal cancer surgery. The patient was a 73-year-old man. He was diagnosed as lower rectal cancer, and underwent laparoscopic super law anterior rectum resection. On the 13th postoperative day, abdominal pain appeared, suspected ileal necrosis, emergencylaparoscopic examination laparotomywas performed. Upper gastrointestinal perforation was suspected from pus and food on the whole intraperitoneal cavity, and we moved laparotomy...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650859/-a-retrospective-study-of-preoperative-concurrent-chemoradiotherapy-for-locally-advanced-resectable-rectal-cancer
#17
Yasutake Uchima, Naoki Aomatsu, Chihoko Nobori, Takuma Okada, Hironari Miyamoto, Shigeaki Kurihara, Ryo Takahashi, En Wang, Toshiki Hirakawa, Takehiko Iwauchi, Junya Morimoto, Kazunori Nakazawa, Kazuhiro Takeuchi
PURPOSE: To analyze chemoradiotherapy results for locally advanced rectal cancers at a single institution. METHODS: The study cohort comprised 12 patients with clinically diagnosed T3/4, NX, M0 adenocarcinomas of the rectum who received preoperative chemoradiotherapy. RESULT: Pathological complete response(pCR)were observed in 2/12(16.7%)patients and pathological downstaging in 5/12(41.7%)patients, with generally mild adverse events. CONCLUSION: Preoperative che- moradiotherapy for clinical T3/4, NX rectal cancers significantly reduces local recurrences and improves prognoses...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650820/-rectal-mucinous-cancer-with-submucosal-tumor-like-morphology-preoperatively-diagnosed-using-eus-fnab-a-case-report
#18
Tomoko Matsumoto, Shiho Kuriyama, Yasuyuki Ohtawa, Toshihiko Waku
A man in his 70s presented with a chiefcomplaint ofbleeding during bowel movements. Subsequent colonoscopy revealed a submucosal tumor-like elevated lesion ofapproximately 4 cm situated in the sigmoid section ofthe rectum. EUS-FNAB was performed, and the lesion was identified as mucinous cancer. Based on a diagnosis of rectal cancer(cT4a, cN0, cM0, cStage II), a low anterior resection was performed. Histopathological analysis of the resected specimen revealed a well-differentiated mucinous cancer. The tumor had ruptured the proper muscular layer and was developing in a submucosal tumor-like manner, protruding from the wall within a fibrous capsule...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29644427/-gender-specific-differences-of-the-early-postoperative-and-oncosurgical-long-term-outcome-in-rectal-cancer-data-obtained-in-a-prospective-multicenter-observational-study
#19
J Katzenstein, R Steinert, H Ptok, R Otto, I Gastinger, H Lippert, F Meyer
BACKGROUND: Gender-specific aspects have been increasingly considered in clinical medicine, also in oncological surgery. AIM: To analyze gender-specific differences of early postoperative and oncological outcomes after rectal cancer resection based on data obtained in a prospective multicenter observational study. PATIENTS AND METHODS: As part of the multicenter prospective observational study "Quality assurance in primary rectal cancer", data on tumor site, exogenic and endogenic risk factors, neoadjuvant treatment, surgical procedures, tumor stage, intraoperative and postoperative complications of patients with the histological diagnosis of rectal cancer were registered...
April 11, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29628634/dosimetric-effect-of-jaw-tracking-in-volumetric-modulated-arc-therapy
#20
Sangutid Thongsawad, Chirasak Khamfongkhruea, Chirapha Tannanonta
The aim of this study was to investigate the potential of jaw tracking with the volumetric-modulated arc therapy (VMAT) to reduce the normal tissue dose. Plans of nasopharynx, lung, and prostate cancers (10 plans for each) were used to perform VMAT with and without jaw tracking. The dose reduction was evaluated in terms of organ doses and integral doses. Organ-dose reduction with jaw tracking was statistically significant in the volume receiving a dose of 5 Gy (V5 ) of bladder, rectum, and lung, the volume receiving a dose of 10 Gy (V10 ) of bladder, rectum, and lung, and the mean dose of lung ( P < 0...
January 2018: Journal of Medical Physics
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