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https://www.readbyqxmd.com/read/29772254/effect-of-interferon-alpha-and-cyclosporine-treatment-separately-and-in-combination-on-middle-east-respiratory-syndrome-coronavirus-mers-cov-replication-in-a-human-in-vitro-and-ex-vivo-culture-model
#1
H S Li, Denise I T Kuok, M C Cheung, Mandy M T Ng, K C Ng, Kenrie P Y Hui, J S Malik Peiris, Michael C W Chan, John M Nicholls
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has emerged as a coronavirus infection of humans in the past 5 years. Though confined to certain geographical regions of the world, infection has been associated with a case fatality rate of 35%, and this mortality may be higher in ventilated patients. As there are few readily available animal models that accurately mimic human disease, it has been a challenge to ethically determine what optimum treatment strategies can be used for this disease. We used in-vitro and human ex-vivo explant cultures to investigate the effect of two immunomodulatory agents, interferon alpha and cyclosporine, singly and in combination, on MERS-CoV replication...
May 14, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29763640/development-of-fluorescent-reverse-transcription-loop-mediated-isothermal-amplification-rt-lamp-using-quenching-probes-for-the-detection-of-the-middle-east-respiratory-syndrome-coronavirus
#2
Kazuya Shirato, Shohei Semba, Sherif A El-Kafrawy, Ahmed M Hassan, Ahmed M Tolah, Ikuyo Takayama, Tsutomu Kageyama, Tsugunori Notomi, Wataru Kamitani, Shutoku Matsuyama, Esam Ibraheem Azhar
Clinical detection of Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) in patients is achieved using genetic diagnostic methods, such as real-time RT-PCR assay. Previously, we developed a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) assay for the detection of MERS-CoV [Virol J. 2014. 11:139]. Generally, amplification of RT-LAMP is monitored by the turbidity induced by precipitation of magnesium pyrophosphate with newly synthesized DNA. However, this mechanism cannot completely exclude the possibility of unexpected reactions...
May 12, 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29753119/replicative-virus-shedding-in-the-respiratory-tract-of-the-patients-with-middle-east-respiratory-syndrome-coronavirus-infection
#3
Wan Beom Park, Leo Lm Poon, Su-Jin Choi, Pyoeng Gyun Choe, Kyoung-Ho Song, Ji Hwan Bang, Eu Suk Kim, Hong Bin Kim, Sang Won Park, Nam Joong Kim, Malik Peiris, Myoung-Don Oh
BACKGROUND: Information on the duration of replicative Middle East respiratory syndrome coronavirus (MERS-CoV) shedding is important for infection control. Detection of MERS-CoV subgenomic mRNAs indicates the virus is replicative. We examined the duration for detecting MERS-CoV subgenomic mRNA compared with genomic RNA in diverse respiratory specimens METHODS: From upper and lower respiratory samples of 17 MERS-CoV-infected patients, MERS-CoV subgenomic mRNA was detected by reverse transcription polymerase chain reaction (RT-PCR) and MERS-CoV genomic RNA was done by real time RT-PCR...
May 9, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29739720/heterologous-prime-boost-vaccination-with-adenoviral-vector-and-protein-nanoparticles-induces-both-th1-and-th2-responses-against-middle-east-respiratory-syndrome-coronavirus
#4
Seo-Yeon Jung, Kyung Won Kang, Eun-Young Lee, Dong-Won Seo, Hong-Lim Kim, Hak Kim, TaeWoo Kwon, Hye-Lim Park, Hun Kim, Sang-Myeong Lee, Jae-Hwan Nam
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic and zoonotic virus with a fatality rate in humans of over 35%. Although several vaccine candidates have been developed, there is still no clinically available vaccine for MERS-CoV. In this study, we developed two types of MERS-CoV vaccines: a recombinant adenovirus serotype 5 encoding the MERS-CoV spike gene (Ad5/MERS) and spike protein nanoparticles formulated with aluminum (alum) adjuvant. Next, we tested a heterologous prime-boost vaccine strategy, which compared priming with Ad5/MERS and boosting with spike protein nanoparticles and vice versa, with homologous prime-boost vaccination comprising priming and boosting with either spike protein nanoparticles or Ad5/MERS...
May 5, 2018: Vaccine
https://www.readbyqxmd.com/read/29737284/middle-east-respiratory-syndrome-coronavirus-mers-mers-cov
#5
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Disease-a-month: DM
https://www.readbyqxmd.com/read/29732571/inactivation-of-ebola-virus-and-middle-east-respiratory-syndrome-coronavirus-in-platelet-concentrates-and-plasma-by-ultraviolet-c-light-and-methylene-blue-plus-visible-light-respectively
#6
Markus Eickmann, Ute Gravemann, Wiebke Handke, Frank Tolksdorf, Stefan Reichenberg, Thomas H Müller, Axel Seltsam
BACKGROUND: Ebola virus (EBOV) and Middle East respiratory syndrome coronavirus (MERS-CoV) have been identified as potential threats to blood safety. This study investigated the efficacy of the THERAFLEX UV-Platelets and THERAFLEX MB-Plasma pathogen inactivation systems to inactivate EBOV and MERS-CoV in platelet concentrates (PCs) and plasma, respectively. STUDY DESIGN AND METHODS: PCs and plasma were spiked with high titers of cell culture-derived EBOV and MERS-CoV, treated with various light doses of ultraviolet C (UVC; THERAFLEX UV-Platelets) or methylene blue (MB) plus visible light (MB/light; THERAFLEX MB-Plasma), and assessed for residual viral infectivity...
May 6, 2018: Transfusion
https://www.readbyqxmd.com/read/29698959/lectin-affinity-plasmapheresis-for-middle-east-respiratory-syndrome-coronavirus-and-marburg-virus-glycoprotein-elimination
#7
Benjamin Koch, Patricia Schult-Dietrich, Stefan Büttner, Bijan Dilmaghani, Dario Lohmann, Patrick C Baer, Ursula Dietrich, Helmut Geiger
BACKGROUND/AIMS: Middle East respiratory syndrome coronavirus (MERS-CoV) and Marburg virus (MARV) are among the World Health Organization's top 8 emerging pathogens. Both zoonoses share nonspecific early symptoms, a high lethality rate, and a reduced number of specific treatment options. Therefore, we evaluated extracorporeal virus and glycoprotein (GP) elimination by lectin affinity plasmapheresis (LAP). METHODS: For both MERS-CoV (pseudovirus) as well as MARV (GPs), 4 LAP devices (Mini Hemopurifiers, Aethlon Medical, San Diego, CA, USA) and 4 negative controls were tested...
April 26, 2018: Blood Purification
https://www.readbyqxmd.com/read/29691378/blockade-of-the-c5a-c5ar-axis-alleviates-lung-damage-in-hdpp4-transgenic-mice-infected-with-mers-cov
#8
Yuting Jiang, Guangyu Zhao, Nianping Song, Pei Li, Yuehong Chen, Yan Guo, Junfeng Li, Lanying Du, Shibo Jiang, Renfeng Guo, Shihui Sun, Yusen Zhou
The pathogenesis of highly pathogenic Middle East respiratory syndrome coronavirus (MERS-CoV) remains poorly understood. In a previous study, we established an hDPP4-transgenic (hDPP4-Tg) mouse model in which MERS-CoV infection causes severe acute respiratory failure and high mortality accompanied by an elevated secretion of cytokines and chemokines. Since excessive complement activation is an important factor that contributes to acute lung injury after viral infection, in this study, we investigated the role of complement in MERS-CoV-induced lung damage...
April 24, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29686521/knowledge-attitude-and-practice-of-secondary-schools-and-university-students-toward-middle-east-respiratory-syndrome-epidemic-in-saudi-arabia-a-cross-sectional-study
#9
Ali Al-Hazmi, Ibrahim Gosadi, Ali Somily, Sarah Alsubaie, Abdulaziz Bin Saeed
This study was aiming to investigate the knowledge, practice and attitudes of secondary school and university students toward MERS-CoV infection. This is a cross-sectional study conducted in Riyadh, Saudi Arabia. Study participants were recruited from several constituent colleges of King Saud University and secondary schools in Riyadh. Data were collected using self-administered, closed-ended questionnaires. Frequencies and proportions were computed for descriptive purposes. Chi square test was utilized to depict statistical difference between groups...
March 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29680581/middle-east-respiratory-syndrome-coronavirus-risk-factors-and-determinants-of-primary-household-and-nosocomial-transmission
#10
REVIEW
David S Hui, Esam I Azhar, Yae-Jean Kim, Ziad A Memish, Myoung-Don Oh, Alimuddin Zumla
Middle East respiratory syndrome coronavirus (MERS-CoV) is a lethal zoonosis that causes death in 35·7% of cases. As of Feb 28, 2018, 2182 cases of MERS-CoV infection (with 779 deaths) in 27 countries were reported to WHO worldwide, with most being reported in Saudi Arabia (1807 cases with 705 deaths). MERS-CoV features prominently in the WHO blueprint list of priority pathogens that threaten global health security. Although primary transmission of MERS-CoV to human beings is linked to exposure to dromedary camels (Camelus dromedarius), the exact mode by which MERS-CoV infection is acquired remains undefined...
April 18, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29673810/a-systematic-review-of-emerging-respiratory-viruses-at-the-hajj-and-possible-coinfection-with-streptococcus-pneumoniae
#11
REVIEW
Jaffar A Al-Tawfiq, Samir Benkouiten, Ziad A Memish
BACKGROUND: The annual Hajj to the Kingdom of Saudi Arabia attracts millions of pilgrims from around the world. International health community's attention goes towards this mass gathering and the possibility of the development of any respiratory tract infections due to the high risk of acquisition of respiratory viruses. METHOD: We searched MEDLINE/PubMed and Scopus databases for relevant papers describing the prevalence of respiratory viruses among Hajj pilgrims...
April 16, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29670390/epidemiological-factors-and-worldwide-pattern-of-middle-east-respiratory-syndrome-coronavirus-from-2013-to-2016
#12
Javad Aghazadeh-Attari, Iraj Mohebbi, Behnam Mansorian, Jamal Ahmadzadeh, Mohammad Mirza-Aghazadeh-Attari, Kazhal Mobaraki, Sima Oshnouei
Background: Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging threat to global health security with high intensity and lethality. This study was conducted to investigate epidemiological factors and patterns related to this disease. Methods: Full details of MERS-CoV cases available on the disease outbreak news section of the World Health Organization official website from January 2013 to November 2016 were retrieved; demographic and clinical information, global distribution status, potential contacts, and probable risk factors for the mortality of laboratory-confirmed MERS-CoV cases were extracted and analyzed by following standard statistical methods...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/29669833/discovery-of-novel-bat-coronaviruses-in-south-china-that-use-the-same-receptor-as-mers-coronavirus
#13
Chu-Ming Luo, Ning Wang, Xing-Lou Yang, Hai-Zhou Liu, Wei Zhang, Bei Li, Ben Hu, Cheng Peng, Qi-Bin Geng, Guang-Jian Zhu, Fang Li, Zheng-Li Shi
Middle East respiratory syndrome coronavirus (MERS-CoV) has represented a human health threat since 2012. Although several MERS-related CoVs, which belong to the same species as MERS-CoV, have been identified from bats, they do not use the MERS-CoV receptor, dipeptidyl peptidase 4 (DPP4). Here, we screened 1059 bat samples from at least 30 bat species collected in different regions in south China and identified 89 strains of lineage C betacoronaviruses, including Tylonycteris pachypus HKU4 , Pipistrellus pipistrellus HKU5, and MERS-related CoVs...
April 18, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29669683/correction-mers-cov-spillover-at-the-camel-human-interface
#14
Gytis Dudas, Luiz Max Carvalho, Andrew Rambaut, Trevor Bedford
No abstract text is available yet for this article.
April 19, 2018: ELife
https://www.readbyqxmd.com/read/29663439/sero-prevalence-of-middle-east-respiratory-syndrome-coronavirus-mers-cov-specific-antibodies-in-dromedary-camels-in-tabuk-saudi-arabia
#15
Rafik Harrath, Faisel M Abu Duhier
The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a novel Coronavirus which was responsible of the first case of human acute respiratory syndrome in the Kingdom of Saudi Arabia (KSA), 2012. Dromedary camels are considered as potential reservoirs for the virus and seem to be the only animal host which may transmit the infection to human. Further studies are required to better understand the animal sources of zoonotic transmission route and the risks of this infection. A primary sero-prevalence study of MERS-CoV preexisting neutralizing antibodies in Dromedary camel serum was conducted in Tabuk, western north region of KSA, in order to assess the seopositivity of these animals and to explain their possible role in the transmission of the infection to Human...
April 16, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29661625/unusual-presentation-of-middle-east-respiratory-syndrome-coronavirus-leading-to-a-large-outbreak-in-riyadh-during-2017
#16
Hala Amer, Abdulrahman S Alqahtani, Hind Alzoman, Nawfal Aljerian, Ziad A Memish
BACKGROUND: The hallmark of Middle East respiratory syndrome coronavirus (MERS-CoV) disease is the ability to cause major health care-associated nosocomial outbreaks with superspreading events leading to massive numbers of cases and excessive morbidity and mortality. In this report, we describe a patient who presented with acute renal failure requiring hemodialysis and became a MERS-CoV superspreader, igniting a recent multihospital outbreak in Riyadh. MATERIAL AND RESULTS: Between May 31 and June 15, 2017, 44 cases of MERS-CoV infection were reported from 3 simultaneous clusters from 3 health care facilities in Riyadh, Saudi Arabia, including 11 fatal cases...
April 13, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29656480/development-of-a-risk-prediction-model-for-middle-east-respiratory-syndrome-coronavirus-infection-in-dialysis-patients
#17
Anwar E Ahmed, Abeer N Alshukairi, Hamdan Al-Jahdali, Mody Alaqeel, Salma S Siddiq, Hanan A Alsaab, Ezzeldin A Sakr, Hamed A Alyahya, Munzir M Alandonisi, Alaa T Subedar, Nouf M Aloudah, Salim Baharoon, Majid A Alsalamah, Sameera Al Johani, Mohammed G Alghamdi
Introduction The Middle East respiratory syndrome coronavirus (MERS-CoV) infection can cause transmission clusters and high mortality in hemodialysis facilities. We attempted to develop a risk-prediction model to assess the early risk of MERS-CoV infection in dialysis patients. Methods This two-center retrospective cohort study included 104 dialysis patients who were suspected of MERS-CoV infection and diagnosed with rRT-PCR between September 2012 and June 2016 at King Fahd General Hospital in Jeddah and King Abdulaziz Medical City in Riyadh...
April 14, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29649550/healthcare-workers-exposure-to-middle-east-respiratory-syndrome-corona-virus-mers-cov-revision-of-screening-strategies-urgently-needed
#18
Hala Amer, Abdulrahman S Alqahtani, Faisal Alaklobi, Juhaina Altayeb, Ziad A Memish
OBJECTIVES: MERS-CoV continues to cause frequent hospital outbreaks in Saudi Arabia with emergency departments as the initial site of the spread of this virus. METHODS: We assessed the transmission risks of MERS-CoV infection to HCWs in an outbreak in Riyadh. All HCWs with unprotected exposure to confirmed cases were tested after 24hours of exposure. Two negative results for MERS-CoV 3days apart and being free of any suggestive signs and symptoms were used to stop their isolation...
April 9, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29624866/factors-associated-with-recovery-delay-in-a-sample-of-patients-diagnosed-by-mers-cov-rrt-pcr-a-saudi-arabian-multicenter-retrospective-study
#19
Anwar E Ahmed, Hamdan Al-Jahdali, Mody Alaqeel, Salma S Siddiq, Hanan A Alsaab, Ezzeldin A Sakr, Hamed A Alyahya, Munzir M Alandonisi, Alaa T Subedar, Yosra Z Ali, Hazza Al Otaibi, Nouf M Aloudah, Salim Baharoon, Sameera Al Johani, Mohammed G Alghamdi
AIM: Research evidence exists that poor prognosis is common in Middle East Respiratory Syndrome Coronavirus (MERS-CoV) patients. This study estimates recovery delay intervals and identifies associated factors in a sample of Saudi Arabian patients admitted for suspected MERS-CoV and diagnosed by rRT-PCR assay. METHOD: A multicenter retrospective study was conducted on 829 patients admitted between September 2012 and June 2016 and diagnosed by rRT-PCR procedures to have MERS-CoV and non-MERS-CoV infection in which 396 achieved recovery...
April 6, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29623560/middle-east-respiratory-syndrome-coronavirus-in-pediatrics-a-report-of-seven-cases-from-saudi-arabia
#20
Sarah H Alfaraj, Jaffar A Al-Tawfiq, Talal A Altuwaijri, Ziad A Memish
Infection with Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 as an important respiratory disease with high fatality rates of 40%-60%. Despite the increased number of cases over subsequent years, the number of pediatric cases remained low. A review of studies conducted from June 2012 to April 19, 2016 reported 31 pediatric MERS-CoV cases. In this paper, we present the clinical and laboratory features of seven patients with pediatric MERS. Five patients had no underlying medical illnesses, and three patients were asymptomatic...
April 6, 2018: Frontiers of Medicine
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