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https://www.readbyqxmd.com/read/29334709/-molecular-epidemiological-study-of-human-coronavirus-oc43-in-shanghai-from-2009-2016
#1
Y J Yang, Y W Hu
Objective: To understand the epidemiological characteristics of Human coronavirus (HCoV), the patterns of emergence and circulation, and the genotype distribution of human coronavirus OC43 (HCoV-OC43) from November, 2009 to April, 2016 in Shanghai. Methods: A total of 6 059 respiratory specimens, including pharyngeal swab, sputum, nasopharyngeal aspirates and alveolar lavage fluid, as well as relative clinical data were collected from patients with acute respiratory infections from seven sentinel hospitals during November, 2009 to April, 2016 in Shanghai...
January 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29330690/extracorporeal-membrane-oxygenation-for-severe-middle-east-respiratory-syndrome-coronavirus
#2
Mohammed S Alshahrani, Anees Sindi, Fayez Alshamsi, Awad Al-Omari, Mohamed El Tahan, Bayan Alahmadi, Ahmed Zein, Naif Khatani, Fahad Al-Hameed, Sultan Alamri, Mohammed Abdelzaher, Amenah Alghamdi, Faisal Alfousan, Adel Tash, Wail Tashkandi, Rajaa Alraddadi, Kim Lewis, Mohammed Badawee, Yaseen M Arabi, Eddy Fan, Waleed Alhazzani
BACKGROUND: Middle East respiratory syndrome (MERS) is caused by a coronavirus (MERS-CoV) and is characterized by hypoxemic respiratory failure. The objective of this study is to compare the outcomes of MERS-CoV patients before and after the availability of extracorporeal membrane oxygenation (ECMO) as a rescue therapy in severely hypoxemic patients who failed conventional strategies. METHODS: We collected data retrospectively on MERS-CoV patients with refractory respiratory failure from April 2014 to December 2015 in 5 intensive care units (ICUs) in Saudi Arabia...
January 10, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29329754/comparison-of-cepheid%C3%A2-xpert-flu-and-roche-realtime-ready-influenza-a-h1n1-detection-set-for-detection-of-influenza-a-h1n1
#3
Ali A Rabaan, Ali M Bazzi, Sana A Alshaikh
OBJECTIVE: To compare two influenza polymerase chain reaction (PCR) methods. METHODS: A total of 749 suspected MERS-CoV patients presenting at Johns Hopkins Aramco Healthcare, Saudi Arabia, each submitted a clinical sample for influenza A reflex testing using the on-site Cepheid® Xpert Flu assay and at the Ministry of Health laboratory by the Roche PCR assay. RESULTS: There was 92.12% overall agreement between the two methods. Specificity of the Cepheid® Xpert Flu was 95...
December 16, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29299855/the-persistent-prevalence-and-evolution-of-cross-family-recombinant-coronavirus-gccdc1-among-a-bat-population-a-two-year-follow-up
#4
Joseph O Obameso, Hong Li, Hao Jia, Min Han, Shiyan Zhu, Canping Huang, Yuhui Zhao, Min Zhao, Yu Bai, Fei Yuan, Honglan Zhao, Xia Peng, Wen Xu, Wenjie Tan, Yingze Zhao, Kwok-Yung Yuen, William J Liu, Lin Lu, George F Gao
Bats are connected with the increasing numbers of emerging and re-emerging viruses that may break the species barrier and spread into the human population. Coronaviruses are one of the most common viruses discovered in bats, which were considered as the natural source of recent human-susceptible coronaviruses, i.e. SARS-COV and MERS-CoV. Our previous study reported the discovery of a bat-derived putative cross-family recombinant coronavirus with a reovirus gene p10, named as Ro-BatCoV GCCDC1. In this report, through a two-year follow-up of a special bat population in one specific cave of south China, we illustrate that Ro-BatCoV GCCDC1 persistently circulates among bats...
December 1, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/29299151/analysis-of-the-codon-usage-pattern-in-middle-east-respiratory-syndrome-coronavirus
#5
Ye Chen, Quanming Xu, Xiaomin Yuan, Xinxin Li, Ting Zhu, Yanmei Ma, Ji-Long Chen
Middle East Respiratory Syndrome Coronavirus (MERS-CoV), which first broken out in Jeddah in 2012, causes a severe acute respiratory illness with a high mortality rate. To better understand the molecular characteristics of isolated MERS-CoV genomes, we first analysed the codon usage pattern of the zoonotic MERS-CoV strains comprehensively to gain an insight into the mechanism of cross-species transmission. We found that MERS human/camel isolates showed a low codon usage bias. Both mutation and nature selection pressure have contributed to this low codon usage bias, with the former being the main determining factor...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29289665/disulfiram-can-inhibit-mers-and-sars-coronavirus-papain-like-proteases-via-different-modes
#6
Min-Han Lin, David C Moses, Chih-Hua Hsieh, Shu-Chun Cheng, Yau-Hung Chen, Chiao-Yin Sun, Chi-Yuan Chou
Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in southern China in late 2002 and caused a global outbreak with a fatality rate around 10% in 2003. Ten years later, a second highly pathogenic human CoV, MERS-CoV, emerged in the Middle East and has spread to other countries in Europe, North Africa, North America and Asia. As of November 2017, MERS-CoV had infected at least 2102 people with a fatality rate of about 35% globally, and hence there is an urgent need to identify antiviral drugs that are active against MERS-CoV...
December 28, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29277291/adaptive-evolution-influences-the-infectious-dose-of-mers-cov-necessary-to-achieve-severe-respiratory-disease
#7
Madeline G Douglas, Jacob F Kocher, Trevor Scobey, Ralph S Baric, Adam S Cockrell
We recently established a mouse model (288-330+/+) that developed acute respiratory disease resembling human pathology following infection with a high dose (5 × 106 PFU) of mouse-adapted MERS-CoV (icMERSma1). Although this high dose conferred fatal respiratory disease in mice, achieving similar pathology at lower viral doses may more closely reflect naturally acquired infections. Through continued adaptive evolution of icMERSma1 we generated a novel mouse-adapted MERS-CoV (maM35c4) capable of achieving severe respiratory disease at doses between 103 and 105 PFU...
December 22, 2017: Virology
https://www.readbyqxmd.com/read/29273879/correction-to-simultaneous-detection-of-severe-acute-respiratory-syndrome-middle-east-respiratory-syndrome-and-related-bat-coronaviruses-by-real-time-reverse-transcription-pcr
#8
Ji Yeong Noh, Sun-Woo Yoon, Doo-Jin Kim, Moo-Seung Lee, Ji-Hyung Kim, Woonsung Na, Daesub Song, Dae Gwin Jeong, Hye Kwon Kim
Unfortunately, the concentration unit of plasmids was published incorrectly in the original publication of the article. The concentration unit, 'copies/ml' should be corrected to 'copies/μl'. This changes do not affect to the analytic sensitivity of the method because the detection limits of 50-100 copies/μL and 5-100 copies/μL using pUC57-SARS-pS2 (a template for SARS-CoV) and pGEM-MERS-S2 (a template for MERS-CoV), respectively, were as sensitive as other real-time PCR methods [1].
December 22, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29261430/investigating-the-effects-of-mass-media-exposure-on-the-uptake-of-preventive-measures-by-hong-kong-residents-during-the-2015-mers-outbreak-the-mediating-role-of-interpersonal-communication-and-the-perception-of-concern
#9
Ramona Ludolph, Peter J Schulz, Ling Chen
In 2015, South Korea experienced the largest outbreak to date of the Middle East Respiratory Syndrome (MERS-CoV) outside the Middle East. Fears related to a potential spread of the disease led to an increased alert level as well as heightened media coverage in the neighboring Hong Kong. A cross-sectional survey (N = 533) among residents of Hong Kong was conducted to assess the relationships between the effects of outbreak-related mass media coverage, interpersonal communication, the perceived level of concern in one's close environment, and the uptake of preventive measures...
December 20, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/29258862/broad-spectrum-antiviral-activity-of-the-eif4a-inhibitor-silvestrol-against-corona-and-picornaviruses
#10
Christin Müller, Falk W Schulte, Kerstin Lange-Grünweller, Wiebke Obermann, Ramakanth Madhugiri, Stephan Pleschka, John Ziebuhr, Roland K Hartmann, Arnold Grünweller
Coronaviruses (CoV) and picornaviruses are plus-strand RNA viruses that use 5' cap-dependent and cap-independent strategies, respectively, for viral mRNA translation initiation. Here, we analyzed the effects of the plant compound silvestrol, a specific inhibitor of the DEAD-box RNA helicase eIF4A, on viral translation using a dual luciferase assay and virus-infected primary cells. Silvestrol was recently shown to have potent antiviral activity in Ebola virus-infected human macrophages. We found that silvestrol is also a potent and non-toxic inhibitor of cap-dependent viral mRNA translation in CoV-infected human embryonic lung fibroblast (MRC-5) cells...
December 16, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29258555/detection-and-full-genome-characterization-of-two-beta-cov-viruses-related-to-middle-east-respiratory-syndrome-from-bats-in-italy
#11
Ana Moreno, Davide Lelli, Luca de Sabato, Guendalina Zaccaria, Arianna Boni, Enrica Sozzi, Alice Prosperi, Antonio Lavazza, Eleonora Cella, Maria Rita Castrucci, Massimo Cicozzi, Gabriele Vaccari
BACKGROUND: Middle East respiratory syndrome coronavirus (MERS-CoV), which belongs to beta group of coronavirus, can infect multiple host species and causes severe diseases in humans. Multiple surveillance and phylogenetic studies suggest a bat origin. In this study, we describe the detection and full genome characterization of two CoVs closely related to MERS-CoV from two Italian bats, Pipistrellus kuhlii and Hypsugo savii. METHODS: Pool of viscera were tested by a pan-coronavirus RT-PCR...
December 19, 2017: Virology Journal
https://www.readbyqxmd.com/read/29249267/coronaviruses-and-arteriviruses-display-striking-differences-in-their-cyclophilin-a-dependence-during-replication-in-cell-culture
#12
Adriaan H de Wilde, Jessika C Zevenhoven-Dobbe, Corrine Beugeling, Udayan Chatterji, Danielle de Jong, Philippe Gallay, Karoly Szuhai, Clara C Posthuma, Eric J Snijder
Cyclophilin A (CypA) is an important host factor in the replication of a variety of RNA viruses. Also the replication of several nidoviruses was reported to depend on CypA, although possibly not to the same extent. These prior studies are difficult to compare, since different nidoviruses, cell lines and experimental set-ups were used. Here, we investigated the CypA dependence of three distantly related nidoviruses that can all replicate in Huh7 cells: the arterivirus equine arteritis virus (EAV), the alphacoronavirus human coronavirus 229E (HCoV-229E), and the betacoronavirus Middle East respiratory syndrome coronavirus (MERS-CoV)...
December 14, 2017: Virology
https://www.readbyqxmd.com/read/29246504/a-recombinant-vsv-vectored-mers-cov-vaccine-induces-neutralizing-antibody-and-t-cell-responses-in-rhesus-monkeys-after-single-dose-immunization
#13
Renqiang Liu, Jinliang Wang, Yu Shao, Xijun Wang, Huilei Zhang, Lei Shuai, Jinying Ge, Zhiyuan Wen, Zhigao Bu
Middle East respiratory syndrome coronavirus (MERS-CoV) has been a highly threatening zoonotic pathogen since its outbreak in 2012. Similar to SARS-CoV, MERS-CoV belongs to the coronavirus family and can induce severe respiratory symptoms in humans, with an average case fatality rate of 35% according to the World Health Organization. Spike (S) protein of MERS-CoV is immunogenic and can induce neutralizing antibodies, thus is a potential major target for vaccine development. Here we constructed a chimeric virus based on the vesicular stomatitis virus (VSV) in which the G gene was replaced by MERS-CoV S gene (VSVΔG-MERS)...
December 12, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29239484/inactivation-of-middle-east-respiratory-syndrome-coronavirus-in-human-plasma-using-amotosalen-and-ultraviolet-a-light
#14
Salwa I Hindawi, Anwar M Hashem, Ghazi A Damanhouri, Sherif A El-Kafrawy, Ahmed M Tolah, Ahmed M Hassan, Esam I Azhar
BACKGROUND: Middle East respiratory syndrome-coronavirus (MERS-CoV) is a novel zoonotic pathogen. Although the potential for MERS-CoV transmission through blood transfusion is not clear, MERS-CoV was recognized as a pathogen of concern for the safety of the blood supply especially after its detection in whole blood, serum, and plasma of infected individuals. Here we investigated the efficacy of amotosalen and ultraviolet A light (UVA) to inactivate MERS-CoV in fresh-frozen plasma (FFP)...
December 14, 2017: Transfusion
https://www.readbyqxmd.com/read/29239118/zoonotic-origin-and-transmission-of-middle-east-respiratory-syndrome-coronavirus-in-the-uae
#15
C R Paden, M F B M Yusof, Z M Al Hammadi, K Queen, Y Tao, Y M Eltahir, E A Elsayed, B A Marzoug, O K A Bensalah, A I Khalafalla, M Al Mulla, K A Elkheir, Z B Issa, K Pradeep, F N Elsaleh, H Imambaccus, J Sasse, S Weber, M Shi, J Zhang, Y Li, H Pham, L Kim, A J Hall, S I Gerber, F I Al Hosani, S Tong, S S M Al Muhairi
Since the emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, there have been a number of clusters of human-to-human transmission. These cases of human-to-human transmission involve close contact and have occurred primarily in healthcare settings, and they are suspected to result from repeated zoonotic introductions. In this study, we sequenced whole MERS-CoV genomes directly from respiratory samples collected from 23 confirmed MERS cases in the United Arab Emirates (UAE). These samples included cases from three nosocomial and three household clusters...
December 13, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29232459/definitive-diagnosis-in-suspected-middle-east-respiratory-syndrome-coronavirus-cases
#16
Elisa Rubio, Miguel J Martínez, Verónica Gonzalo, Josep Barrachina, Núria Torner, Ana I Martínez, Mireia Jané, Anna Vilella, Ana Del Rio, Natalia Rodriguez-Valero, Maria Jesús Pinazo, José Muñoz, Alex Soriano, Antoni Trilla, Jordi Vila, Ma Ángeles Marcos
We evaluated the microbiological diagnosis in 14 patients with epidemiological and clinical suspicion of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) attended in a non-endemic area between June 2015 and January 2017. While no MERS-CoV was detected, other respiratory viruses were identified in 12 cases and Mycoplasma pneumoniae in 1 case.
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29228581/a-multiplex-liquid-chip-assay-based-on-luminex-xmap-technology-for-simultaneous-detection-of-six-common-respiratory-viruses
#17
Yong Yan, Jian-Yong Luo, Yin Chen, Heng-Hui Wang, Guo-Ying Zhu, Pei-Yan He, Jin-Lei Guo, Yong-Liang Lei, Zhong-Wen Chen
We utilized one-step multiplex reverse transcription-PCR (RT-PCR) and Luminex xMAP technology to develop a respiratory multiplex liquid-chip assay (rMLA) for simultaneous detection of 6 common respiratory viruses, including influenza virus type A (FluA) and type B (FluB), para-influenza virus type 3 (PIV-3), respiratory syncytial virus (RSV), human metapneumovirus (MPV) and a threatening virus to China, Middle East Respiratory Syndrome coronavirus (MERS-CoV). Performance of rMLA was evaluated by comparing with real-time RT-PCR...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29223614/host-susceptibility-to-mers-cov-infection-a-retrospective-cohort-study-of-the-2015-korean-mers-outbreak
#18
Jae-Hoon Ko, Hyeri Seok, Ga Eun Park, Ji Yeon Lee, Ji Yong Lee, Sun Young Cho, Young Eun Ha, Ji-Man Kang, Yae-Jean Kim, Cheol-In Kang, Doo Ryeon Chung, Jae-Hoon Song, Kyong Ran Peck
To evaluate host susceptibility factors to Middle East respiratory syndrome coronavirus (MERS-CoV) infection, we conducted a retrospective cohort study from the single largest exposure event of the 2015 Korean MERS outbreak. A total of 175 patients were closely exposed to a super-spreader, 26 of which were infected (14.9%). In a multivariate analysis, history of autologous stem cell transplantation (HR, 31.151; 95% CI, 5.447-178.145; P < 0.001) and tachypnea at ED (HR, 4.392; 95% CI, 1.402-13.761; P = 0...
December 6, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29207494/an-opportunistic-pathogen-afforded-ample-opportunities-middle-east-respiratory-syndrome-coronavirus
#19
REVIEW
Ian M Mackay, Katherine E Arden
The human coronaviruses (CoV) include HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1, some of which have been known for decades. The severe acute respiratory syndrome (SARS) CoV briefly emerged into the human population but was controlled. In 2012, another novel severely human pathogenic CoV-the Middle East Respiratory Syndrome (MERS)-CoV-was identified in the Kingdom of Saudi Arabia; 80% of over 2000 human cases have been recorded over five years. Targeted research remains key to developing control strategies for MERS-CoV, a cause of mild illness in its camel reservoir...
December 2, 2017: Viruses
https://www.readbyqxmd.com/read/29201911/transmissible-gastroenteritis-virus-papain-like-protease-1-antagonizes-production-of-interferon-%C3%AE-through-its-deubiquitinase-activity
#20
Xiaoliang Hu, Jin Tian, Hongtao Kang, Dongchun Guo, Jiasen Liu, Dafei Liu, Qian Jiang, Zhijie Li, Juanjuan Qu, Liandong Qu
Coronaviruses (CoVs), such as human coronavirus NL63 (HCoV-NL63), severe acute respiratory syndrome CoV (SARS-CoV), murine hepatitis virus (MHV), porcine epidemic diarrhea virus (PEDV), and Middle East Respiratory Syndrome Coronavirus (MERS-CoV), encode papain-like (PL) proteases that inhibit Sendai virus- (SeV-) induced interferon (IFN-β) production. Recently, the crystal structure of transmissible gastroenteritis virus (TGEV) PL1 has been solved, which was similar to that of SARS-CoV PL2pro, which may antagonize host innate immunity...
2017: BioMed Research International
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