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https://www.readbyqxmd.com/read/28906430/identification-of-a-novel-inhibitor-against-middle-east-respiratory-syndrome-coronavirus
#1
Yaping Sun, Huaidong Zhang, Jian Shi, Zhe Zhang, Rui Gong
The Middle East respiratory syndrome coronavirus (MERS-CoV) was first isolated in 2012, and circulated worldwide with high mortality. The continual outbreaks of MERS-CoV highlight the importance of developing antiviral therapeutics. Here, we rationally designed a novel fusion inhibitor named MERS-five-helix bundle (MERS-5HB) derived from the six-helix bundle (MERS-6HB) which was formed by the process of membrane fusion. MERS-5HB consists of three copies of heptad repeat 1 (HR1) and two copies of heptad repeat 2 (HR2) while MERS-6HB includes three copies each of HR1 and HR2...
September 14, 2017: Viruses
https://www.readbyqxmd.com/read/28906003/inclusion-of-mers-spike-protein-elisa-in-algorithm-to-determine-serologic-evidence-of-mers-cov-infection
#2
Suvang Trivedi, Congrong Miao, Mohammad Mousa Al-Abdallat, Aktham Haddadin, Sultan Alqasrawi, Ibrahim Iblan, Mohannad Al Nsour, Tarek Alsanouri, Sami Sheikh Ali, Brian Rha, Susan I Gerber, Daniel C Payne, Azaibi Tamin, Natalie J Thornburg
The Centers for Disease Control and Prevention (CDC) algorithm for detecting presence of serum antibodies against Middle East Respiratory Syndrome coronavirus (MERS-CoV) in subjects with potential infections with the virus has included screening by indirect ELISA against recombinant nucleocapsid (N) protein and confirmation by immunofluorescent staining of infected monolayers and/or microneutralization titration. Other international groups include indirect ELISA assays using the spike (S) protein, as part of their serological determinations...
September 14, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28902913/identification-of-diverse-viruses-in-upper-respiratory-samples-in-dromedary-camels-from-united-arab-emirates
#3
Yan Li, Abdelmalik Ibrahim Khalafalla, Clinton R Paden, Mohammed F Yusof, Yassir M Eltahir, Zulaikha M Al Hammadi, Ying Tao, Krista Queen, Farida Al Hosani, Susan I Gerber, Aron J Hall, Salama Al Muhairi, Suxiang Tong
Camels are known carriers for many viral pathogens, including Middle East respiratory syndrome coronavirus (MERS-CoV). It is likely that there are additional, as yet unidentified viruses in camels with the potential to cause disease in humans. In this study, we performed metagenomic sequencing analysis on nasopharyngeal swab samples from 108 MERS-CoV-positive dromedary camels from a live animal market in Abu Dhabi, United Arab Emirates. We obtained a total of 846.72 million high-quality reads from these nasopharyngeal swab samples, of which 2...
2017: PloS One
https://www.readbyqxmd.com/read/28900197/structural-insights-into-the-middle-east-respiratory-syndrome-coronavirus-4a-protein-and-its-dsrna-binding-mechanism
#4
Maria Batool, Masaud Shah, Mahesh Chandra Patra, Dhanusha Yesudhas, Sangdun Choi
Middle East respiratory syndrome coronavirus (MERS-CoV) has evolved to navigate through the sophisticated network of a host's immune system. The immune evasion mechanism including type 1 interferon and protein kinase R-mediated antiviral stress responses has been recently attributed to the involvement of MERS-CoV protein 4a (p4a) that masks the viral dsRNA. However, the structural mechanism of how p4a recognizes and establishes contacts with dsRNA is not well explained. In this study, we report a dynamic mechanism deployed by p4a to engage the viral dsRNA and make it unavailable to the host immune system...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28900101/impact-of-comorbidity-on-fatality-rate-of-patients-with-middle-east-respiratory-syndrome
#5
Ya-Min Yang, Chen-Yang Hsu, Chao-Chih Lai, Ming-Fang Yen, Paul S Wikramaratna, Hsiu-Hsi Chen, Tsung-Hsi Wang
To date, 1841 cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection have been reported worldwide, with 652 deaths. We used a publically available case line list to explore the effect of relevant factors, notably underlying comorbidities, on fatal outcome of Middle East respiratory syndrome (MERS) cases up to the end of October 2016. A Bayesian Weibull proportional hazards regression model was used to assess the effect of comorbidity, age, epidemic period and sex on the fatality rate of MERS cases and its variation across countries...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28894474/a-novel-dynamic-model-describing-the-spread-of-the-mers-cov-and-the-expression-of-dipeptidyl-peptidase-4
#6
Siming Tang, Wanbiao Ma, Peifan Bai
The Middle East respiratory syndrome (MERS) coronavirus, a newly identified pathogen, causes severe pneumonia in humans. MERS is caused by a coronavirus known as MERS-CoV, which attacks the respiratory system. The recently defined receptor for MERS-CoV, dipeptidyl peptidase 4 (DPP4), is generally expressed in endothelial and epithelial cells and has been shown to be present on cultured human nonciliated bronchiolar epithelium cells. In this paper, a class of novel four-dimensional dynamic model describing the infection of MERS-CoV is given, and then global stability of the equilibria of the model is discussed...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28893197/the-predictors-of-3-and-30-day-mortality-in-660-mers-cov-patients
#7
Anwar E Ahmed
BACKGROUND: The mortality rate of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) patients is a major challenge in all healthcare systems worldwide. Because the MERS-CoV risk-standardized mortality rates are currently unavailable in the literature, the author concentrated on developing a method to estimate the risk-standardized mortality rates using MERS-CoV 3- and 30-day mortality measures. METHODS: MERS-CoV data in Saudi Arabia is publicly reported and made available through the Saudi Ministry of Health (SMOH) website...
September 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28885377/clinical-pearls-in-venovenous-extracorporeal-life-support-for-adult-respiratory-failure
#8
Chee Kiang Tay, Kiick Sung, Yang Hyun Cho
Extracorporeal life support (ECLS) has been widely utilized to treat neonatal respiratory failure for two decades. However, its uptake in the case of adult respiratory failure has been slow because of a paucity of quality evidence and a sluggish tempo of ECLS-related technological advances. In recent years, interest in ECLS has been piqued after encouraging results were reported from its use during the 2009 H1N1 influenza pandemic. In a world constantly under threat from another influenza epidemic or deadly novel respiratory infection, e...
September 6, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28875620/mers-cov-infection-in-a-pregnant-woman-in-korea
#9
Soo Young Jeong, Se In Sung, Ji Hee Sung, So Yoon Ahn, Eun Suk Kang, Yun Sil Chang, Won Soon Park, Jong Hwa Kim
Middle East respiratory syndrome (MERS) is a lethal respiratory disease - caused by MERS-coronavirus (MERS-CoV) which was first identified in 2012. Especially, pregnant women can be expected as highly vulnerable candidates for this viral infection. In May 2015, this virus was spread in Korea and a pregnant woman was confirmed with positive result of MERS-CoV polymerase chain reaction (PCR). Her condition was improved only with conservative treatment. After a full recovery of MERS, the patient manifested abrupt vaginal bleeding with rupture of membrane...
October 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28873020/assessing-the-detection-of-middle-east-respiratory-syndrome-coronavirus-igg-in-suspected-and-proven-cases-of-middle-east-respiratory-syndrome-coronavirus-infection
#10
Abdulkarim Alhetheel, Haifa Altalhi, Ahmed Albarrag, Zahid Shakoor, Deqa Mohamed, Malak El-Hazmi, Ali Somily, Mazin Barry, Muhammed Bakhrebah, Majed Nassar
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease with significant mortality. Two testing methods are currently used for MERS-CoV diagnostics: nucleic acid detection (the gold standard) and serological analysis. In this study, we evaluated the detection of MERS-CoV-IgG in suspected and proven cases of MERS-CoV infection. We enrolled 174 patients: 113 had respiratory symptoms/suspected MERS-CoV infection, 31 had confirmed influenza A or B infection, 23 had a recent confirmed MERS-CoV infection, and 7 had confirmed MERS-CoV infection 1 year before...
September 5, 2017: Viral Immunology
https://www.readbyqxmd.com/read/28869153/a-multi-faceted-approach-of-a-nursing-led-education-in-response-to-mers-cov-infection
#11
Jaffar A Al-Tawfiq, Siobhan Rothwell, Heather A Mcgregor, Zeina A Khouri
BACKGROUND: The emergence of the Middle East respiratory syndrome-coronavirus (MERS-CoV) resulted in multiple healthcare associated outbreaks. In response, we developed a nurse-led program to screen and triage patients with MERS-CoV infection. METHODS: A formal educational program was implemented to ensure a standardized approach to care planning and delivery. The essential skills that were included were the use of Personal Protective Equipment (PPE) including gown, gloves, head cover and N95 mask, hand hygiene, the practice of donning and doffing and the collection of MERS-CoV nasopharyngeal specimens...
August 28, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28864360/current-treatment-options-and-the-role-of-peptides-as-potential-therapeutic-components-for-middle-east-respiratory-syndrome-mers-a-review
#12
REVIEW
Sabeena Mustafa, Hanan Balkhy, Musa Nur Gabere
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a highly pathogenic respiratory virus with mechanisms that may be driven by innate immune responses. Despite the effort of scientific studies related to this virus, Middle East Respiratory Syndrome (MERS) is still a public health concern. MERS-CoV infection has a high mortality rate, and to date, no therapeutic or vaccine has been discovered, that is effective in treating or preventing the disease. In this review, we summarize our understanding of the molecular and biological events of compounds acting as MERS-CoV inhibitors, the outcomes of existing therapeutic options and the various drugs undergoing clinical trials...
August 29, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28858401/histopathology-of-middle-east-respiratory-syndrome-coronovirus-mers-cov-infection-clinicopathological-and-ultrastructural-study
#13
Khaled O Alsaad, Ali H Hajeer, Mohammed Al Balwi, Mohammed Al Moaiqel, Nourah Al Oudah, Abdulaziz Al Ajlan, Sameera AlJohani, Sami Alsolamy, Giamal E Gmati, Hanan Balkhy, Hamdan H Al-Jahdali, Salim A Baharoon, Yaseen M Arabi
AIMS: The pathogenesis, viral localization and histopathological features of Middle East Respiratory Syndrome - Coronavirus (MERS-CoV) in human are not sufficiently described. The aims of this study were to explore and define the spectrum of histological and ultrastructural pathological changes affecting various organs in a patient with MERS-CoV infection and represent a base of MERS-CoV histopathology. METHODS AND RESULTS: We analyzed the postmortem histopathological findings and investigated viral particles localization in the pulmonary and extra-pulmonary tissue by transmission electron microscopic examination in a 33-year-old male patient of T-cell lymphoma, who acquired MERS-CoV infection...
August 31, 2017: Histopathology
https://www.readbyqxmd.com/read/28855003/a-review-of-candidate-therapies-for-middle-east-respiratory-syndrome-from-a-molecular-perspective
#14
Ali A Rabaan, Shamsah H Alahmed, Ali M Bazzi, Hatem M Alhani
There have been 2040 laboratory-confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) in 27 countries, with a mortality rate of 34.9 %. There is no specific therapy. The current therapies have mainly been adapted from severe acute respiratory syndrome (SARS-CoV) treatments, including broad-spectrum antibiotics, corticosteroids, interferons, ribavirin, lopinavir-ritonavir or mycophenolate mofetil, and have not been subject to well-organized clinical trials. The development of specific therapies and vaccines is therefore urgently required...
August 31, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28846484/vaccines-for-emerging-infectious-diseases-lessons-from-mers-coronavirus-and-zika-virus
#15
Joel N Maslow
The past decade and a half has been characterized by numerous emerging infectious diseases. With each new threat, there has been a call for rapid vaccine development. Pathogens such as the Middle East Respiratory Syndrome coronavirus (MERS-CoV) and the Zika virus represent either new viral entities or viruses emergent in new geographic locales and characterized bywith novel complications. Both serve as paradigms for the global spread that can accompany new pathogens. In this paper, we review the epidemiology and pathogenesis of MERS-CoV and Zika virus with respect to vaccine development...
August 28, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28845258/a25%C3%A2-phylogenetic-analysis-of-the-nucleocapsid-and-rna-dependent-rna-polymerase-fragments-of-the-first-imported-case-of-middle-east-respiratory-syndrome-coronavirus-mers-cov-infection-in-the-philippines-from-saudi-arabia-february-2015
#16
I A P Medado, J R C Orbina, N T M Yabut, L L M Dancel, T C Tan, M A U Igoy, A M R Mojica, I C Lirio, A C Ablola, B C Mateo, M A J Biol, A D Nicolasora, H L E Morito, K I M Cruz, C M F Roldan, P B Medina, E S Mercado, C S Demetria, R J Capistrano, S P Lupisan
No abstract text is available yet for this article.
March 2017: Virus Evolution
https://www.readbyqxmd.com/read/28845242/a46%C3%A2-mers-cov-in-arabian-camels-in-africa-and-central-asia
#17
Daniel K W Chu, Samuel M S Chan, Ranawaka A P M Perera, Eve Miguel, F Roger, V Chevalier, Leo L M Poon, Malik Peiris
No abstract text is available yet for this article.
March 2017: Virus Evolution
https://www.readbyqxmd.com/read/28843094/mers-coronavirus-nsp1-participates-in-an-efficient-propagation-through-a-specific-interaction-with-viral-rna
#18
Yutaka Terada, Kengo Kawachi, Yoshiharu Matsuura, Wataru Kamitani
MERS-CoV is the only lethal human CoV still endemic in the Arabian Peninsula and neither vaccine nor therapeutics against MERS-CoV infection is available. The nsp1 of CoV is thought to be a major virulence factor because it suppresses protein synthesis through the degradation of host mRNA. In contrast, viral RNA circumvents the nsp1-mediated translational shutoff for an efficient propagation. In this study, we identified amino acid residue in MERS-CoV nsp1 that differ from those of SARS-CoV nsp1, and that appear to be crucial for circumventing the translational shutoff...
August 23, 2017: Virology
https://www.readbyqxmd.com/read/28840986/performance-evaluation-of-the-powerchek-mers-upe-orf1a-real-time-pcr-kit-for-the-detection-of-middle-east-respiratory-syndrome-coronavirus-rna
#19
Hee Jae Huh, Ji Youn Kim, Hyeon Jeong Kwon, Sun Ae Yun, Myoung Keun Lee, Chang Seok Ki, Nam Yong Lee, Jong Won Kim
BACKGROUND: Molecular detection of Middle East respiratory syndrome coronavirus (MERS-CoV) using real-time reverse transcription (rRT)-PCR assays is the method of choice for diagnosis of MERS. We evaluated the performance of the PowerChek MERS (upE & ORF1a) real-time PCR Kit (PowerChek MERS assay; Kogene Biotech, Korea) a one-step rRT-PCR assay for the qualitative detection of MERS-CoV. METHODS: We evaluated PowerChek MERS assay performance in comparison with nested RT-PCR and sequencing of the RNA-dependent RNA polymerase (RdRp) and N genes...
November 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28840828/imported-case-of-middle-east-respiratory-syndrome-coronavirus-mers-cov-infection-from-oman-to-thailand-june-2015
#20
Tanarak Plipat, Rome Buathong, Supaporn Wacharapluesadee, Potjaman Siriarayapon, Chakrarat Pittayawonganon, Chariya Sangsajja, Thongchai Kaewpom, Sininat Petcharat, Teerada Ponpinit, Jaruphan Jumpasri, Yutthana Joyjinda, Apaporn Rodpan, Siriporn Ghai, Akanitt Jittmittraphap, Sarawut Khongwichit, Duncan R Smith, Victor M Corman, Christian Drosten, Thiravat Hemachudha
Thailand reported the first Middle East respiratory syndrome (MERS) case on 18 June 2015 (day 4) in an Omani patient with heart condition who was diagnosed with pneumonia on hospital admission on 15 June 2015 (day 1). Two false negative RT-PCR on upper respiratory tract samples on days 2 and 3 led to a 48-hour diagnosis delay and a decision to transfer the patient out of the negative pressure unit (NPU). Subsequent examination of sputum later on day 3 confirmed MERS coronavirus (MERS-CoV) infection. The patient was immediately moved back into the NPU and then transferred to Bamrasnaradura Infectious Disease Institute...
August 17, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
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