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https://www.readbyqxmd.com/read/28222532/prevalence-of-use-of-cardiovascular-drugs-in-dementia-patients-treated-in-general-practices-in-germany
#1
Louis Jacob, Jens Bohlken, Karel Kostev
BACKGROUND: Dementia is a chronic disease associated with numerous cardiovascular disorders. OBJECTIVE: To analyze the prevalence of cardiovascular drug use in dementia patients treated in general practices in Germany. METHODS: The present study included patients who were diagnosed with dementia (Alzheimer's disease, vascular dementia, or unspecified dementia) in 2015. The main outcome measure was the proportion of patients using cardiovascular drugs...
February 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28222221/elastase-2-an-angiotensin-ii-generating-enzyme-contributes-to-increased-ang-ii-in-resistance-arteries-of-mice-with-myocardial-infarction
#2
Christiane Becari, Marcondes A B Silva, Marina T Durand, Cibele M Prado, Eduardo B Oliveira, Mauricio S Ribeiro, Helio C Salgado, Maria Cristina O Salgado, Rita C Tostes
Angiotensin II (Ang II), whose generation largely depends on angiotensin-converting enzyme activity, mediates most of the renin-angiotensin-system effects. Elastase-2 (ELA-2), a chymotrypsin-serine protease elastase family member 2A, alternatively generates Ang II in rat arteries. Myocardial infarction (MI) leads to intense RAS activation, but mechanisms involved on Ang II-generation in resistance arteries are unknown. We hypothesized that ELA-2 contributes to vascular Ang II generation and to cardiac damage in mice submitted to MI...
February 21, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28219128/-correlation-between-polymorphism-of-angiotensin-converting-enzyme-gene-and-the-lower-extremity-atherosclerosis-in-type-2-diabetes-mellitus-patients
#3
Y Wang, T H Zhu, J W Tong, J F Wei, J X Sheng, X P Jin, L H Mu, X Chen
Objective: To explore the correlation between polymorphism of the angiotensin-converting enzyme (ACE) gene and lower extremity atherosclerosis (LEA) in type 2 diabetes mellitus (T2DM) patients. Methods: A total of 380 patients diagnosed with T2DM in Department of Endocrinology from June 2015 to March 2016 were enrolled and divided into two groups: group A had no LEA (n=120) and group B had LEA(n=260). Color doppler ultrasound was used to detect the vascular lesions of the patients. For all patients in groups A and B, the polymerase chain reaction (PCR) was applied to determined the insertion/deletion polymorphism in intron 16 of the ACE gene of the patients...
February 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28216378/gender-differences-in-adverse-childhood-experiences-collective-violence-and-the-risk-for-addictive-behaviors-among-university-students-in-tunisia
#4
Sana El Mhamdi, Andrine Lemieux, Ines Bouanene, Arwa Ben Salah, Motohiro Nakajima, Kamel Ben Salem, Mustafa al'Absi
Adverse childhood experiences (ACE) have been linked to a variety of addictive behaviors. The recent adaptation of the ACE measure by the World Health Organization (WHO) allows for the assessment of the negative role of additional adverse experiences, such as extra-familial violence. To date, the relationship between extra-familial violence and addictive behaviors has not been assessed. We report the contribution of ACEs, including the new scales for extra-familial violence, on the risk for mental health problems and addictive behaviors by gender in a sample of young adults in Tunisia...
February 16, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28215703/structure-and-function-of-vibrio-cholerae-accessory-cholera-enterotoxin-in-presence-of-gold-nanoparticles-dependence-on-morphology
#5
Tanaya Chatterjee, Barun K Chatterjee, Tultul Saha, Kazi Mirajul Hoque, Pinak Chakrabarti
BACKGROUND: Accessory cholera enterotoxin (Ace) is a classical enterotoxin produced by Vibrio cholerae, the causative agent for cholera. Considering the crucial role of Ace in pathogenesis of cholera, we explored the modulation of structure/function of Ace using gold nanoparticles (AuNPs) of different size and shape - spherical (AuNS10 and AuNS100, the number indicating the diameter in nm) and rod (AuNR10). METHODS: Biophysical techniques have been used to find out structural modulation of Ace by AuNPs...
February 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28215475/an-ace-in-the-hole-unraveling-gastrointestinal-bleeding-in-left-ventricular-assist-systemsan-ace-in-the-hole-unraveling-gastrointestinal-bleeding-in-left-ventricular-assist-systemsretain
#6
EDITORIAL
James W Schurr, Craig A Stevens, Mandeep R Mehra
No abstract text is available yet for this article.
January 30, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28215000/angiotensin-ii-receptor-blockers-attenuate-lipopolysaccharide-induced-memory-impairment-by-modulation-of-nf-%C3%AE%C2%BAb-mediated-bdnf-creb-expression-and-apoptosis-in-spontaneously-hypertensive-rats
#7
Ruby Goel, Shahnawaz Ali Bhat, Kashif Hanif, Chandishwar Nath, Rakesh Shukla
Clinical studies demonstrated a positive correlation between hypertension and cognitive decline. Beneficial effects of angiotensin II receptor blockers on cognitive functions have also been reported earlier; however, its role in chronic neuroinflammation-induced memory impairment in the hypertensive state is not well understood. Therefore, in the present study, we investigated the effect of angiotensin II receptor blockers on memory impairment induced by lipopolysaccharide (LPS) in spontaneously hypertensive rats (SHRs)...
February 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28212269/separation-and-characterization-of-angiotensin-i-converting-enzyme-ace-inhibitory-peptides-from-saurida-elongata-proteins-hydrolysate-by-imac-ni-2
#8
Lixia Sun, Shanguang Wu, Liqin Zhou, Feng Wang, Xiongdiao Lan, Jianhua Sun, Zhangfa Tong, Dankui Liao
Lizard fish protein hydrolysates (LFPH) were prepared from Lizard fish (Saurida elongata) proteins possessing powerful angiotensin I converting enzyme (ACE) inhibitory activity and the fraction (LFPH-I) with high ACE inhibitory activity was obtained through ultrafiltration. The active Fraction (F2) was isolated from LFPH-I using immobilized metal affinity chromatography (IMAC-Ni(2+)). Analysis of amino acid levels revealed that F2 eluted from IMAC was enriched in Met, His, Tyr, Pro, Ile, and Leu compared to the crude peptide LFPH-I...
February 15, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28210891/aquatic-monitoring-programs-conducted-during-environmental-impact-assessments-in-canada-preliminary-assessment-before-and-after-weakened-environmental-regulation
#9
Brynn Roach, Tony R Walker
Aquatic monitoring programs are imperative for the functioning of the environmental impact assessment (EIA) process and a cornerstone for industrial compliance in Canada. However, in 2012, several leading pieces of federal environmental legislation (e.g., Canadian Environmental Assessment Act c.19, s. 52, 2012) were drastically altered, effectively weakening levels of environmental protection for aquatic ecosystems during project developments. This paper assesses the impact of CEAA 2012 on aquatic monitoring programs (and subsequent monitoring data reporting) across Canada for ten projects (five completed pre-CEAA 2012 and five completed post-CEAA 2012)...
March 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28209920/effect-of-captopril-on-radiation-induced-tgf-%C3%AE-1-secretion-in-ea-hy926-human-umbilical-vein-endothelial-cells
#10
Jingni Wei, Hui Xu, Yinyin Liu, Baiyu Li, Fuxiang Zhou
The pathophysiological mechanism involved in the sustained endothelial secretion of cytokines that leads to fibrosis 6-16 months after radiotherapy remains unclear. Angiotensin II (Ang II) is produced by the endothelium in response to stressing stimuli, like radiation, and may induce the synthesis of TGF-β, a profibrotic cytokine. In this study we tested the hypothesis that captopril, an angiotensin-converting enzyme (ACE) inhibitor, inhibits or attenuates radiation-induced endothelial TGF-β1 secretion. The human endothelial hybrid cell line EA...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28209222/roles-of-angiotensin-peptides-and-recombinant-human-ace2-in-heart-failure
#11
Ratnadeep Basu, Marko Poglitsch, Haran Yogasundaram, Jissy Thomas, Brian H Rowe, Gavin Y Oudit
BACKGROUND: The renin-angiotensin system (RAS) is activated in heart failure (HF) and inhibition of RAS is a mainstay therapy for HF. Angiotensin-converting enzyme 2 (ACE2) and its product, angiotensin 1-7 (Ang-[1-7]), are important negative regulators of the RAS. OBJECTIVES: A comprehensive examination of angiotensin peptide levels and therapeutic effects of recombinant human ACE2 (rhACE2) on peptide metabolism was evaluated in human plasma and explanted heart tissue from patients with HF...
February 21, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28207324/is-serum-angiotensin-converting-enzyme-level-useful-for-determining-necroinflammatory-activity-in-chronic-hepatitis-b-infection
#12
Ahmet Tay, Fatih Albayrak, Sevilay Ozmen, Ayse Albayrak, Kemalettin Ozden
AIM: The purpose of this study was to investigate the relationship between the findings from liver biopsy and the serum angiotensin-converting enzyme (ACE) level to determine whether ACE might serve as a potential noninvasive sign of necroinflammatory activity in patients with Chronic Hepatitis B (CHB) infection. METHODS: A total of 54 CHB patients referred for liver biopsy were enrolled in the study. Serum ACE levels were determined photometrically with a kinetic test...
February 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28207279/angiotensin-converting-inhibitors-and-angiotensin-ii-receptor-blockers-and-longitudinal-change-in-percent-emphysema-on-computed-tomography-the-mesa-lung-study
#13
Megha A Parikh, Carrie P Aaron, Eric A Hoffman, Joseph E Schwartz, Jaime Madrigano, John H M Austin, Ravi Kalhan, Gina Lovasi, Karol Watson, Karen Hinckley Stukovsky, R Graham Barr
RATIONALE: Chronic obstructive pulmonary disease (COPD) is the third-leading cause of death in the United States. Emphysema on computed tomography (CT) is associated with increased morbidity and mortality in patients with and without spirometrically defined COPD but no available medications target emphysema.  Transforming growth factor beta (TGF-β) and endothelial dysfunction are implicated in emphysema pathogenesis, and angiotensin II receptor blockers (ARB) inhibit TGF-β, improve endothelial function and restore airspace architecture in murine models...
February 16, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28202024/who-cone-bio-assays-of-classical-and-new-generation-long-lasting-insecticidal-nets-call-for-innovative-insecticides-targeting-the-knock-down-resistance-mechanism-in-benin
#14
Marius Allossogbe, Virgile Gnanguenon, Boulais Yovogan, Bruno Akinro, Rodrigue Anagonou, Fiacre Agossa, André Houtoukpe, Germain Gil Padonou, Martin Akogbeto
BACKGROUND: To increase the effectiveness of insecticide-treated nets (ITN) in areas of high resistance, new long-lasting insecticidal nets (LLINs) called new-generation nets have been developed. These nets are treated with the piperonyl butoxide (PBO) synergist which inhibit the action of detoxification enzymes. The effectiveness of the new-generation nets has been proven in some studies, but their specific effect on mosquitoes carrying detoxification enzymes and those carrying both detoxification enzymes and the knock-down resistance gene in Benin is not well known...
February 15, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28196559/the-link-between-childhood-adversity-and-late-life-mental-health-evidence-for-the-influence-of-early-life-experiences-or-illusory-correlations
#15
Tracy D Vannorsdall, Cynthia A Munro
Adverse childhood experiences (ACEs) reflect stressful or traumatic early life events such as abuse, neglect, and significant household challenges. These experiences are increasingly appreciated as factors that exert influence on physical and mental functioning throughout the lifespan. Numerous studies have demonstrated dose-response relationships between the number of ACEs reported and negative health outcomes in adulthood (Anda et al., 2006). At the same time, evidence points to the role of ACEs in the development of heightened biological reactivity to stress that may serve to increase vulnerability to the development of mental and substance use disorders (e...
March 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28196137/effects-of-dietary-nutrient-levels-on-microbial-community-composition-and-diversity-in-the-ileal-contents-of-pregnant-huanjiang-mini-pigs
#16
Yujiao Ji, Xiangfeng Kong, Huawei Li, Qian Zhu, Qiuping Guo, Yulong Yin
The mammalian gut microbiota influences various metabolic and physiological processes. Substantial metabolic changes occur during a healthy pregnancy that may be related to microbiota composition dynamics. However, the effect of diet on intestinal microbiota composition and diversity during pregnancy remains unclear. We examined the ileal contents of Huanjiang mini-pigs at two pregnancy stages to determine the effects of dietary nutrient levels on such microbial communities. Animals received either a higher-nutrient (HN) diet formulated to meet US National Research Council requirements or a lower-nutrient (LN) diet that met the Chinese National Feeding Standard recommendations...
2017: PloS One
https://www.readbyqxmd.com/read/28195972/individual-and-combined-influence-of-ace-and-actn3-genes-on-muscle-phenotypes-in-polish-athletes
#17
Joanna Orysiak, Joanna Mazur-Różycka, Krzysztof Busko, Jan Gajewski, Beata Szczepanska, Jadwiga Malczewska-Lenczowska
The aim of this study was to examine the association between ACE and ACTN3 genes, independently or in combination, and muscle strength and power in male and female athletes. The study involved 398 young male (n=266) and female (n=132) athletes representing various sport disciplines (ice hockey, canoeing, swimming, volleyball). All were Caucasians. The following measurements were taken: height of jump and mechanical power in countermovement jump (CMJ) and spike jump (SPJ), and muscle strength of 10 muscle groups (flexors and extensors of the elbow, shoulder, hip, knee and trunk)...
February 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28195465/identification-and-relative-quantification-of-bioactive-peptides-sequentially-released-during-simulated-gastrointestinal-digestion-of-commercial-kefir
#18
Yufang Liu, Monika Pischetsrieder
Health-promoting effects of kefir may be partially caused by bioactive peptides. To evaluate their formation or degradation during gastrointestinal digestion, we monitored changes of the peptide profile in a model of oral (1), gastric (2) and small intestinal (3) digestion of kefir. MALDI-TOF-MS analyses revealed clearly different profiles between digests 2/3 and kefir/digest 1. Subsequent UPLC-ESI-MS/MS identified 92 peptides in total (25, 25, 43, and 30, partly overlapping in kefir and digests 1, 2, and 3, respectively), including 16 peptides with ascribed bioactivity...
February 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28193328/engineering-neurospora-crassa-for-cellobionate-production-directly-from-cellulose-without-any-enzyme-addition
#19
Hui Lin, Amanda Hildebrand, Takao Kasuga, Zhiliang Fan
In a cellulosic biorefinery, the cellulase enzymes needed for hydrolysis are one of the major contributors to high processing costs, while the hydrolysis product, cellobiose, has strong inhibition to the cellulases. In this study, we report engineering recombinant Neurospora crassa strains which are able to produce cellobionate, an organic acid, from cellulose without any enzyme addition. Recombinant strains were constructed by heterologously expressing laccase genes from different sources under different promoters in N...
April 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/28192475/adverse-cardiac-effects-of-exogenous-angiotensin-1-7-in-rats-with-subtotal-nephrectomy-are-prevented-by-ace-inhibition
#20
Louise M Burrell, Daniel Gayed, Karen Griggs, Sheila K Patel, Elena Velkoska
We previously reported that exogenous angiotensin (Ang) 1-7 has adverse cardiac effects in experimental kidney failure due to its action to increase cardiac angiotensin converting enzyme (ACE) activity. This study investigated if the addition of an ACE inhibitor (ACEi) to Ang 1-7 infusion would unmask any beneficial effects of Ang 1-7 on the heart in experimental kidney failure. Male Sprague-Dawley rats underwent subtotal nephrectomy (STNx) and were treated with vehicle, the ACEi ramipril (oral 1mg/kg/day), Ang 1-7 (subcutaneous 24 μg/kg/h) or dual therapy (all groups, n = 12)...
2017: PloS One
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