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https://www.readbyqxmd.com/read/29909460/modulation-of-brain-ace-and-ace2-may-be-a-promising-protective-strategy-against-cerebral-ischemia-reperfusion-injury-an-experimental-trial-in-rats
#1
Maha Mohammed Abdel-Fattah, Basim Anwar Shehata Messiha, Ahmed Mohamed Mansour
The brain renin-angiotensin system (RAS) is considered a crucial regulator for physiological homeostasis and disease progression. We evaluated the protective effects of the angiotensin receptor blocker (ARB) telmisartan and the angiotensin-converting enzyme 2 (ACE2) activator xanthenone on experimental cerebral ischemia/reperfusion (I/R) injury. Rats were divided into a sham control, a cerebral I/R control, a standard treatment (nimodipine, 10 mg/kg/day, 15 days, p.o.), three telmisartan treatments (1, 3, and 10 mg/kg/day, 15 days, p...
June 17, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29908974/severe-infrarenal-atheroma-load-in-open-aortic-aneurysm-repair-is-not-a-risk-factor-for-postoperative-acute-kidney-injury
#2
S Ooms, B Nemeth, J J Wever, B Knippenberg, H van Overhagen, R G Statius van Eps
OBJECTIVES: Acute Kidney Injury (AKI) after open aortic repair is subject to multiple patient- and operation-related variables. Hostile neck morphology in open aneurysm repair is thought to contribute to this AKI risk post-operatively. The aim of this study was to evaluate if large neck atheroma is a possible risk factor in the postoperative development of AKI. METHODS: Retrospectively 137 patients were evaluated for neck atheroma and AKI incidence. Atheroma load measurements were performed by two different techniques...
June 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29908436/adverse-experiences-in-infancy-and-toddlerhood-relations-to-adaptive-behavior-and-academic-status-in-middle-childhood
#3
Lorraine M McKelvey, Nicola Conners Edge, Glenn R Mesman, Leanne Whiteside-Mansell, Robert H Bradley
Findings from the Adverse Childhood Experiences (ACE) study articulated the negative effects of childhood trauma on long-term well-being. The purpose of the current study is to examine the associations between ACEs experienced in infancy and toddlerhood and adaptive behavior and academic status in middle childhood. We used data collected from a sample of low-income families during the impacts study of Early Head Start (EHS). Data were collected by trained interviewers demonstrating at least 85% reliability with protocols...
June 13, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29906739/an-effective-measure-of-childhood-adversity-that-is-valid-with-older-adults
#4
Ramona Danielson, Gregory F Sanders
Childhood adversity (CA) has life-long effects that we are just beginning to understand. The Midlife in the United States (MIDUS) data is a rich resource that could contribute to the knowledge of the impact of CA in the later years but, while a number of CA items are included in MIDUS, a cumulative CA scale based on those items has not been created. Development of a CA scale would create numerous research opportunities within MIDUS and overcome some of the challenges of using a secondary dataset. The present study aimed to demonstrate that a cumulative measure of CA that is valid with older adults could be created using retrospective MIDUS Refresher study data (Ryff et al...
June 12, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29904624/profiling-the-urinary-microbiota-in-male-patients-with-bladder-cancer-in-china
#5
Peng Wu, Guihao Zhang, Jie Zhao, Jiawei Chen, Yang Chen, Weina Huang, Jialei Zhong, Jiarong Zeng
Mounting evidence indicates that microbiome plays an important role in the development and progression of cancer. The dogma that urine in healthy individuals must be sterile has been overturned. Dysbiosis of the urinary microbiome has been revealed responsible for various urological disorders, including prostate cancer. The link between chronic inflammation, microbiome and solid tumors has been established for various neoplastic diseases. However, a detailed and comprehensive analysis of urinary microenvironment of bladder cancer has not been yet reported...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29904593/case-report-pulmonary-and-liver-sarcoidosis-suspected-of-metastasis
#6
Behnam Jafari, Gholamabas Sabz, Elahe Masnavi, Roghaye Panahi, Saeid Jokar, Amrollah Roozbehi, Sajad Hasanzadeh
Introduction : Sarcoidosis is a granulomatous disease with unknown cause that can vary from an asymptomatic condition. Almost half of the patients with sarcoidosis have no symptoms. In this article, we describe a sarcoidosis patient with lung and liver engagement; it may be confused with metastasis. Case report : A 39-year-old man, known as hypothyroidism who had come to the emergency ward with dyspnea and coughing after exposure to detergents in a closed environment A 39-year-old man, known as hypothyroidism who had come to the emergency ward with dyspnea and coughing after exposure to detergents in a closed environment...
2018: F1000Research
https://www.readbyqxmd.com/read/29904374/alpha-ketoglutarate-in-low-protein-diets-for-growing-pigs-effects-on-cecal-microbial-communities-and-parameters-of-microbial-metabolism
#7
Jiashun Chen, Baoju Kang, Qian Jiang, Mengmeng Han, Yurong Zhao, Lina Long, Chenxing Fu, Kang Yao
Alpha-ketoglutarate (AKG), a critical molecule in the tricarboxylic acid cycle, is beneficial to intestinal functions. However, its influence on intestinal microbiota and metabolism is not fully understood. We investigated the effects of a low-protein (LP) diet supplemented with AKG on cecal microbial communities and the parameters of microbial metabolism in growing pigs. Twenty-seven young pigs (Large White × Landrace) with an average initial body weight of 11.96 ± 0.18 kg were randomly allotted into three groups ( n = 9): a normal protein (NP) diet containing 20% crude protein (CP); LP diet formulated with 17% CP (LP diet); or LP diet supplemented with 10 g kg-1 of AKG (ALP diet)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29904189/mitigation-of-radiation-myelopathy-and-reduction-of-microglial-infiltration-by-ramipril-ace-inhibitor
#8
Mariano G Clausi, Alexander M Stessin, Stella E Tsirka, Samuel Ryu
STUDY DESIGN: Experimental study. OBJECTIVES: To evaluate the efficacy of Angiotensin-converting enzyme inhibitor Ramipril, as a mitigator of radiation-induced spinal cord injury. SETTING: Stony Brook University, Stony Brook, NY, USA. METHODS: Total of 22 rats were irradiated with single doses of 23.6-33 Gy at the C4-T2 spinal levels. After irradiation, the rats were randomized to the radiation only control group and the Ramipril-treated (radiation + Ramipril) experimental group...
June 14, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29903781/how-good-are-gps-at-adhering-to-a-pragmatic-trial-protocol-in-primary-care-results-from-the-addition-cambridge-cluster-randomised-pragmatic-trial
#9
Michael Laxy, Edward C F Wilson, Clare E Boothby, Simon J Griffin
OBJECTIVE: To assess the fidelity of general practitioners' (GPs) adherence to a long-term pragmatic trial protocol. DESIGN: Retrospective analyses of electronic primary care records of participants in the pragmatic cluster-randomised ADDITION (Anglo-Danish-Dutch Study of Intensive Treatment In People with Screen Detected Diabetes in Primary Care)-Cambridge trial, comparing intensive multifactorial treatment (IT) versus routine care (RC). Data were collected from the date of diagnosis until December 2010...
June 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29900411/the-effect-of-different-combinations-of-vascular-dependency-and-cognitive-endpoints-on-the-sample-size-required-to-detect-a-treatment-effect-in-trials-of-treatments-to-improve-outcome-after-lacunar-and-non-lacunar-ischaemic-stroke
#10
Stephen Dj Makin, Fergus N Doubal, Terence J Quinn, Philip Mw Bath, Martin S Dennis, Joanna M Wardlaw
Background: Endpoints that are commonly used in trials of moderate/severe stroke may be less frequent in patients with minor, non-disabling stroke thus inflating sample sizes. We tested whether trial efficiency might be improved with composite endpoints. Methods: We prospectively recruited patients with lacunar and minor non-lacunar ischaemic stroke (NIHSS ≤ 7) and assessed recurrent vascular events (stroke, transient ischaemic attack (TIA), ischemic heart disease (IHD)), modified Rankin Score (mRS) and cognitive testing with the Addenbrooke's Cognitive Examination (ACE-R) one year post-stroke...
March 2018: European stroke journal
https://www.readbyqxmd.com/read/29900167/a-force-balanced-fragmentation-method-for-ab-initio-molecular-dynamic-simulation-of-protein
#11
Mingyuan Xu, Tong Zhu, John Z H Zhang
A force balanced generalized molecular fractionation with conjugate caps (FB-GMFCC) method is proposed for ab initio molecular dynamic simulation of proteins. In this approach, the energy of the protein is computed by a linear combination of the QM energies of individual residues and molecular fragments that account for the two-body interaction of hydrogen bond between backbone peptides. The atomic forces on the caped H atoms were corrected to conserve the total force of the protein. Using this approach, ab initio molecular dynamic simulation of an Ace-(ALA)9 -NME linear peptide showed the conservation of the total energy of the system throughout the simulation...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29899290/correction-sun-y-et-al-design-synthesis-and-evaluation-of-novel-2-hydroxypyrrolobenzodiazepine-5-11-dione-analogues-as-potent-angiotensin-converting-enzyme-ace-inhibitors-molecules-2017-22-1739
#12
Ying Sun, Yujun Bai, Xirui He, Yajun Bai, Pei Liu, Zefeng Zhao, Xufei Chen, Xiaohui Zheng
The author wishes to make the following corrections to this paper [...].
June 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29898489/-ace-inhibitors-and-arb-in-chronic-kidney-disease-what-has-to-be-considered
#13
Martin Zeier
Proteinuric kidney disease, especially in the early and middle stages of renal insufficiency, may be favorably affected by ACE-I/ARB. The progression of renal insufficiency is thereby slowed down and dialysis obligation occurs later or can even be avoided. This effect is independent of the underlying glomerular kidney disease. In the advanced stage of renal insufficiency, the benefit of ACE-I/ARB cannot yet be conclusively assessed. The interruption of ACE-I/ARB therapy may possibly contribute to a certain recovery of renal function and delay the onset of dialysis a little...
June 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29898484/-drug-prescribing-for-patients-with-chronic-kidney-disease-in-general-practice-a-cross-sectional-study
#14
Maria Mahner, Christina Raus, Fabian Ludwig, Gesine Weckmann, Sylvia Stracke, Jean-François Chenot
BACKGROUND:  Many drugs require dose adjustment or are contraindicated in patients with chronic kidney disease (CKD) to avoid adverse events. The aims of this study were to assess if medication was appropriately dose adjusted in patients with CKD in primary care, to identify medications that were frequently prescribed inappropriately and to identify factors predicting mal-prescription. METHODS:  We conducted a cross-sectional observational study in 34 general practioners' offices, assessing the medication of patients with CKD stage ≥ 3 according to the corresponding pharmaceutical product information...
June 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29897099/hypotensive-drugs-and-syncope-due-to-orthostatic-hypotension-in-older-adults-with-dementia-syncope-and-dementia-study
#15
Gianluca Testa, Alice Ceccofiglio, Chiara Mussi, Giuseppe Bellelli, Franco Nicosia, Mario Bo, Daniela Riccio, Francesco Curcio, Anna Maria Martone, Gabriele Noro, Francesco Landi, Andrea Ungar, Pasquale Abete
OBJECTIVES: To determine whether hypotensive drugs may play a pivotal role in inducing orthostatic hypotension (OH)-related syncope. DESIGN: Prospective, observational, multicenter study. SETTING: Acute care wards, syncope units, and centers for the diagnosis of dementia. PARTICIPANTS: Individuals aged 65 and older with a diagnosis of dementia and 1 or more episodes of transient loss of consciousness of a suspected syncopal nature or unexplained falls during the previous 3 months MEASUREMENTS: Blood pressure was measured in the supine position and in the orthostatic position after 1 and 3 minutes...
June 13, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29896188/analysis-of-beijing-douzhir-microbiota-by-high-throughput-sequencing-and-isolation-of-acidogenic-starch-flocculating-strains
#16
Yunhe Xu, Yang Yu, Yumin Tian, Yuhong Su, Xiaona Li, Zhen Zhang, Hongyan Zhu, Jie Han, Huajiang Zhang, Liying Liu, Lili Zhang
Beijing Douzhir is a traditional Chinese fermented drink produced by the natural fermentation of mung beans as the raw material. Ma tofu is an edible by-product of Douzhir processing. Douzhir microbiota, particularly bacteria involved in the natural fermentation process, has not been clearly established, resulting in limited industrial Douzhir production. Here, three uncooked Douzhir samples (D group) and three uncooked Ma tofu samples (M group) (two replicates per sample) were collected from three manufacturers in different locations in Beijing...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29893359/correlation-between-sex-and-prognosis-of-acute-aortic-dissection-in-the-chinese-population
#17
Yan-Jie Liu, Xiao-Zeng Wang, Ya Wang, Rui-Xia He, Lin Yang, Quan-Min Jing, Hai-Wei Liu
Background: The prevalence, presentation, management, and prognosis of coronary heart disease differ according to sex. Greater understanding on the differences between men and women with acute aortic dissection (AAD) is needed. We aimed to investigate whether sex disparities are found in patients with AAD, and to study sex differences in complications, mortality in-hospital, and long-term. Methods: We included 884 patients enrolled in our institute between June 2002 and May 2016...
June 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29892833/treatment-of-hypertension-in-chronic-kidney-disease
#18
REVIEW
Rigas G Kalaitzidis, Moses S Elisaf
PURPOSE OF REVIEW: Chronic kidney disease (CKD) is recognized as a worldwide epidemic. Hypertension commonly coexists with CKD and its prevalence is progressively increasing as kidney function declines. RECENT FINDINGS: For patients with established CKD and/or diabetes with albuminuria, the updated hypertension guidelines have recommended a blood pressure (BP) goal < 130/80 mmHg. Blood pressure level above 130/80 mmHg in CKD patients requires lifestyle modifications and multiple antihypertensive medications...
June 11, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29891825/adverse-childhood-experiences-and-hospital-treated-self-harm
#19
Seonaid Cleare, Karen Wetherall, Andrea Clark, Caoimhe Ryan, Olivia J Kirtley, Michael Smith, Rory C O'Connor
Adverse childhood experiences (ACEs) have been implicated in a range of negative health outcomes in adulthood, including increased suicide mortality. In this study, we explored the relationship between ACEs and hospital-treated self-harm. Specifically, we investigated whether those who had a history of repeat self-harm reported more ACEs than those who had self-harmed for the first time. Patients ( n = 189) admitted to two hospitals in Glasgow (UK) following first-time ( n = 41) or repeated ( n = 148) self-harm completed psychosocial measures...
June 11, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29891744/angiotensin-converting-enzyme-gene-insertion-deletion-variant-and-familial-mediterranean-fever-related-amyloidosis
#20
Ayse Feyda Nursal, Ercan Turkmen, Suheyla Uzun Kaya, Akin Tekcan, Ozlem Sezer, Sumeyya Deniz Celik, Serbulent Yigit
INTRODUCTION: The most important complication of familial Mediterranean fever (FMF) is secondary amyloidosis, which can lead to kidney failure. Genetic variability in the genes of various components of the renin-angiotensin system may play a role in the pathogenesis of the kidney disorders.  The aim of the present study was to investigate the association between angiotensin converting enzyme (ACE) gene I/D variant and risk of developing FMF-related amyloidosis in Turkish patients. MATERIALS AND METHODS: A total of 240 individuals consisting of 40 patients with FMF-related amyloidosis, 100 FMF patients without amyloidosis, and 100 healthy controls were recruited...
May 2018: Iranian Journal of Kidney Diseases
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