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https://www.readbyqxmd.com/read/27932972/the-ace-brain
#1
Massimiliano Zanin, David Papo
No abstract text is available yet for this article.
2016: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/27932705/possible-role-for-glomerular-derived-angiotensinogen-in-nephrotic-syndrome
#2
Mihoko Yamazaki, Yoshiyasu Fukusumi, Mutsumi Kayaba, Yukina Kitazawa, Sayuri Takamura, Ichiei Narita, Hiroshi Kawachi
BACKGROUND AND OBJECTIVE: Renin-angiotensin system (RAS) inhibitors reduce glomerular injury and proteinuria, indicating that angiotensin II (Ang II) is involved in glomerular diseases. Although the local RAS is reported to play an essential role in maintaining local tissue functions, the role of the local RAS in regulating glomerular function is not well evaluated. In this study, we analyzed the glomerular expression of RAS components in nephrotic models and the effect of Ang II receptor blockers (ARB) on the expression of angiotensinogen (AGT)...
October 2016: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/27931559/role-of-cardiac-renin-angiotensin-system-in-ischemia-reperfusion-injury-and-preconditioning-of-heart
#3
REVIEW
Vimal Agrawal, Jeetendra Kumar Gupta, Shaiba Sana Qureshi, Vishal Kumar Vishwakarma
Cardio-vascular diseases are the leading cause of morbidity and mortality. Ischemia is a state of oxygen deprivation in tissues, whereas reperfusion is restoration of blood flow in ischemic tissues. Myocardial damage of tissue during reperfusion after ischemic insult is known as myocardial ischemia-reperfusion (I/R) injury. It induces damage to cardiac muscle via increasing expression of oxygen, sodium and calcium ions which are responsible in the activation of proteases and cell death. Heart renin angiotensin system (RAS) plays an important role in the myocardial ischemia and reperfusion injury...
November 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27929222/ace-inhibitors-or-arbs-to-prevent-ckd-in-patients-with-microalbuminuria
#4
Jason M Corbo, Teresa M Delellis, Lucas G Hill, Sarah L Rindfuss, Joan Nashelsky
No abstract text is available yet for this article.
October 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/27928554/bleomycin-induced-neonatal-lung-injury-requires-the-autocrine-pulmonary-angiotensin-system
#5
Abdellatif Abdelwahab, Indiwari Gopallawa, Christopher C Piasecki, Ira H Gewolb, Bruce D Uhal
BACKGROUND: Previous work from this laboratory demonstrated that apoptosis is regulated by a local angiotensin (ANG) system in alveolar epithelial cells (AECs). Autocrine generation of angiotensin II (ANGII) in response to endogenous or xenobiotic inducers is required for apoptosis in adult rat AECs and in AEC-derived human lung carcinoma cell line A549. Therefore, we hypothesized that a similar mechanism might also be involved in bleomycin (Bleo)-induced murine neonatal lung injury. METHODS: To investigate the local production of angiotensinogen (AGT) and ANGII in neonatal lung injury, lung explants were obtained from C57/BL6 wild type neonatal mice and were treated with Bleo in the presence or absence of an angiotensin converting enzyme (ACE) inhibitor...
September 2016: Jacobs J Pulmonol
https://www.readbyqxmd.com/read/27928199/association-of-anxiety-related-polymorphisms-with-sports-performance-in-chilean-long-distance-triathletes-a-pilot-study
#6
Jorge A Sanhueza, Tomás Zambrano, Carlos Bahamondes-Avila, Luis A Salazar
Different factors affecting athletic performance are well established: intensity and type of training, anthropometric characteristics as well as an important psychological component. However, the contribution of the genetic background has been less investigated. The aim of the present study was to investigate the influence of polymorphisms within genes associated with stress and anxiety (5HTT, CRH2R, ACE, NK1R, 5HT1AR and CRF-BP) on the physical capability and sports performance in triathletes. One hundred and ninety two (192) unrelated Chilean triathletes who participated in the 2014 70...
December 2016: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/27928138/essential-oil-composition-antioxidant-antidiabetic-and-antihypertensive-properties-of-two-afromomum-species
#7
Stephen Adeniyi Adefegha, Tosin Abiola Olasehinde, Ganiyu Oboh
This study was designed to assess the antioxidant, antidiabetic and antihypertensive effects of essential oils from A. melegueta and A. danielli seeds. The essential oils were extracted via hydrodistillation, dried with anhydrous Na2SO4 and characterized using gas chromatography-mass spectrometry (GC-MS). Antioxidant properties and inhibition of some pro-oxidant induced lipid peroxidation in rats' pancreas and heart homogenates were also determined. The results revealed that eugenol, eucalyptol, α-terpineol, α-caryophyllene and β-caryophyllene were the most abundant components in A...
December 8, 2016: Journal of Oleo Science
https://www.readbyqxmd.com/read/27927733/participant-and-public-involvement-in-refining-a-peer-volunteering-active-aging-intervention-project-ace-active-connected-engaged
#8
Janet Withall, Janice L Thompson, Kenneth R Fox, Mark Davis, Selena Gray, Jolanthe de Koning, Liz Lloyd, Graham Parkhurst, Afroditi Stathi
BACKGROUND: Evidence for the health benefits of a physically active lifestyle among older adults is strong, yet only a small proportion of older people meet physical activity recommendations. A synthesis of evidence identified "best bet" approaches, and this study sought guidance from end-user representatives and stakeholders to refine one of these, a peer-volunteering active aging intervention. METHODS: Focus groups with 28 older adults and four professional volunteer managers were conducted...
December 7, 2016: Gerontologist
https://www.readbyqxmd.com/read/27927602/acute-change-in-glomerular-filtration-rate-with%C3%A2-inhibition-of-the-renin-angiotensin-system-does-not%C3%A2-predict-subsequent-renal-and-cardiovascular%C3%A2-outcomes
#9
Catherine M Clase, Joshua Barzilay, Peggy Gao, Andrew Smyth, Roland E Schmieder, Sheldon Tobe, Koon K Teo, Salim Yusuf, Johannes F E Mann
Initiation of blockade of the renin-angiotensin system may cause an acute decrease in glomerular filtration rate (GFR): the prognostic significance of this is unknown. We did a post hoc analysis of patients with, or at risk for, vascular disease, in two randomized controlled trials: Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial (ONTARGET) and the Telmisartan Randomized AssessmeNt Study in ACE iNtolerant participants with cardiovascular Disease (TRANSCEND), whose median follow-up was 56 months...
December 4, 2016: Kidney International
https://www.readbyqxmd.com/read/27926769/myocardial-fibrosis-progression-in-duchenne-and-becker-muscular-dystrophy-a-randomized-clinical-trial
#10
Marly Conceição Silva, Tiago Augusto Magalhães, Zilda Maria Alves Meira, Carlos Henrique Reis Esselin Rassi, Amanda Cristina de Souza Andrade, Paulo Sampaio Gutierrez, Clerio Francisco Azevedo, Juliana Gurgel-Giannetti, Mariz Vainzof, Mayana Zatz, Roberto Kalil-Filho, Carlos Eduardo Rochitte
Importance: In Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), interventions reducing the progression of myocardial disease could affect survival. Objective: To assess the effect of early angiotensin-converting enzyme (ACE) inhibitor therapy in patients with normal left ventricular function on the progression of myocardial fibrosis (MF) identified on cardiovascular magnetic resonance (CMR). Design, Setting, and Participants: A randomized clinical trial conducted in 2 centers included 76 male patients with DMD or BMD undergoing 2 CMR studies with a 2-year interval for ventricular function and MF assessment...
December 7, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27926639/angiotensin-converting-enzyme-inhibitors-and-the-risk-of-congenital-malformations
#11
Brian T Bateman, Elisabetta Patorno, Rishi J Desai, Ellen W Seely, Helen Mogun, Sara Z Dejene, Michael A Fischer, Alexander M Friedman, Sonia Hernandez-Diaz, Krista F Huybrechts
OBJECTIVE: To examine the association between first-trimester angiotensin-converting enzyme (ACE) inhibitor exposure and the risk of overall major congenital, cardiac, and central nervous system malformations. METHODS: We used a cohort of completed pregnancies linked to liveborn neonates derived from Medicaid claims from 2000 to 2010. We examined the risk of malformations associated with first-trimester exposure to an ACE inhibitor. Propensity score-based methods were used to control for potential confounders including maternal demographics, medical conditions, exposure to other medications, and measures of health care utilization...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27925380/angiotensin-converting-enzyme-2-polymorphisms-and-postexercise-hypotension-in-hypertensive-medicated-individuals
#12
Karla F Goessler, Marcos D Polito, Gloria de F Mota, Edilamar M de Oliveira, Véronique A Cornelissen
The renin-angiotensin aldosterone system (RAAS) is associated with diverse physiological responses and adaptations to exercise. The angiotensin converting enzyme (ACE) 2 has vasodilatory effects, which might be associated with the blood pressure (BP) responses to acute exercise. The aim of this study was to investigate the role of ACE2 polymorphisms in postexercise hypotension (PEH). Thirty-four medicated hypertensive (61·3 ± 1·7 years, 76·1 ± 2·7 kg, 160 ± 1·6 cm) men (n = 12) and women (n = 22), participated in a control and a moderate intensity exercise session in a randomized order...
December 7, 2016: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/27924184/revealed-opportunism-how-physicians-game-prior-authorization-protocols-until-they-are-rescinded
#13
Natan R Kahan, Dan-Andrei Waitman, David P Chinitz
BACKGROUND: Prior authorization (PA) is a management technique that has been implemented to manage the utilization of expensive drugs and to improve the precision of drug prescribing. PA requirements may incentivize physicians to document adverse effects, sometimes falsely, to meet the eligibility requirements. OBJECTIVES: To identify documentation patterns that may facilitate the quantitative analysis of physician gaming and underreporting behaviors associated with the prescribing of angiotensin-converting enzyme (ACE) inhibitors in a primary care setting, and to evaluate the effect of a PA requirement on the documentation of adverse events as a way to receive approval for more expensive drugs...
September 2016: American Health & Drug Benefits
https://www.readbyqxmd.com/read/27923785/genetic-determination-of-the-vascular-reactions-in-humans-in-response-to-the-diving-reflex
#14
Tatiana I Baranova, Dmitrii N Berlov, Oleg S Glotov, Ekaterina A Korf, Alexey D Minigalin, Alla V Mitrofanova, Ildus I Ahmetov, Andrey S Glotov
The purpose of this study was to investigate the genetic mechanisms of the defense vascular reactions in response to the diving reflex in humans with polymorphisms in the genes ADBR2, ACE, AGTR1, BDKRB2, and REN. We hypothesized that protective vascular reactions, in response to the diving reflex, are genetically determined and are distinguished in humans with gene polymorphisms of the renin-angiotensin and kinin-bradykinin system. A total of 80 subjects (19±1.4 years) participated in the study. The intensity of the vascular response was estimated using photopletismogram...
December 6, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27923676/megastigmane-glycosides-from-leaves-of-eucommia-ulmoides-oliver-with-ace-inhibitory-activity
#15
Jian-Kun Yan, Li-Qin Ding, Xu-Liu Shi, Paul Owusu Donkor, Li-Xia Chen, Feng Qiu
Four new megastigmane glycosides, eucomegastigsides A-D (2, 3, 5 and 7), together with three known megastigmane glycosides, (6R, 7E, 9R)-9-hydroxy-4, 7-megastigmadien-3-one-9-O-[α-l-arabinopyranosyl-(l→6)-β-d-glucopyranoside (1), foliasalacioside B1 (4) and eleganoside A (6), were isolated from the leaves of Eucommia ulmoides Oliver. Their anti-hypertensive effect was investigated in vitro based on the inhibition of Angiotensin Converting Enzyme (ACE) using HPLC. The results showed that the isolates (2, 3, 4, 5, 7) had moderate inhibitory effects on ACE in vitro compared with captopril...
December 3, 2016: Fitoterapia
https://www.readbyqxmd.com/read/27921395/testing-for-the-erythropoiesis-stimulating-agent-sotatercept-ace-011-actriia-fc-in-serum-by-means-of-western-blotting-and-lc-hrms
#16
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27920360/effects-of-adverse-childhood-experiences-stress-and-social-support-on-the-health-of-college-students
#17
Canan Karatekin, Rohini Ahluwalia
The goal of the study was to describe the nature of adverse childhood experiences (ACEs) reported by undergraduates and to examine the effect of ACEs, perceived stress, and perceived social support on their health. Although respondents (N = 321) had parents with relatively high levels of education and indicated generally high levels of social support, results nevertheless showed a relatively high level of mental health problems and rates of ACEs that were similar to those in the general population in the state...
December 4, 2016: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/27920222/rethinking-the-measurement-of-adversity-moving-toward-second-generation-research-on-adverse-childhood-experiences
#18
Joshua P Mersky, Colleen E Janczewski, James Topitzes
Research on adverse childhood experiences (ACEs) has unified the study of interrelated risks and generated insights into the origins of disorder and disease. Ten indicators of child maltreatment and household dysfunction are widely accepted as ACEs, but further progress requires a more systematic approach to conceptualizing and measuring ACEs. Using data from a diverse, low-income sample of women who received home visiting services in Wisconsin (N = 1,241), this study assessed the prevalence of and interrelations among 10 conventional ACEs and 7 potential ACEs: family financial problems, food insecurity, homelessness, parental absence, parent/sibling death, bullying, and violent crime...
December 5, 2016: Child Maltreatment
https://www.readbyqxmd.com/read/27920083/nocturnal-antihypertensive-treatment-in-patients-with-type-1-diabetes-with-autonomic-neuropathy-and-non-dipping-a-randomised-placebo-controlled-double-blind-cross-over-trial
#19
Henrik Øder Hjortkjær, Tonny Jensen, Klaus F Kofoed, Ulrik M Mogensen, Per Ejlstrup Sigvardsen, Lars Køber, Karen Lisa Hilsted, Helle Corinth, Simone Theilade, Jannik Hilsted
OBJECTIVES: Cardiovascular autonomic neuropathy (CAN) and abnormal circadian blood pressure (BP) rhythm are independent cardiovascular risk factors in patients with diabetes and associations between CAN, non-dipping of nocturnal BP and coronary artery disease have been demonstrated. We aimed to test if bedtime dosing (BD) versus morning dosing (MD) of the ACE inhibitor enalapril would affect the 24-hour BP profile in patients with type 1 diabetes (T1D), CAN and non-dipping. SETTING: Secondary healthcare unit in Copenhagen, Denmark...
December 5, 2016: BMJ Open
https://www.readbyqxmd.com/read/27919970/11c-acetate-pet-ct-compared-to-99mtc-hdp-bone-scintigraphy-in-primary-staging-of-high-risk-prostate-cancer
#20
Sara Strandberg, Camilla Thellenberg Karlsson, Mattias Ogren, Jan Axelsson, Katrine Riklund
AIM: The aim of this study was to evaluate the detection rate of bone metastases and the added value of (11)C-acetate (ACE) positron-emission tomography/computed tomography (PET/CT) compared to bone scintigraphy (BS) in high-risk prostate cancer (PC). MATERIALS AND METHODS: A total of 66 untreated patients with high-risk PC with ACE-PET/CT and planar BS findings within 3 months of each other were retrospectively enrolled. Findings were compared and verified with follow-up data after an average of 26 months...
December 2016: Anticancer Research
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