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https://www.readbyqxmd.com/read/29244716/two-dimensional-fluorescence-difference-spectroscopy-of-zno-and-mg-composites-in-the-detection-of-physiological-protein-and-rna-interactions
#1
Amanda Hoffman, Xiaotong Wu, Jianjie Wang, Amanda Brodeur, Rintu Thomas, Ravindra Thakkar, Halena Hadi, Garry P Glaspell, Molly Duszynski, Adam Wanekaya, Robert K DeLong
Two-dimensional fluorescence difference spectroscopy (2-D FDS) was used to determine the unique spectral signatures of zinc oxide (ZnO), magnesium oxide (MgO), and 5% magnesium zinc oxide nanocomposite (5% Mg/ZnO) and was then used to demonstrate the change in spectral signature that occurs when physiologically important proteins, such as angiotensin-converting enzyme (ACE) and ribonuclease A (RNase A), interact with ZnO nanoparticles (NPs). When RNase A is bound to 5% Mg/ZnO, the intensity is quenched, while the intensity is magnified and a significant shift is seen when torula yeast RNA (TYRNA) is bound to RNase A and 5% Mg/ZnO...
December 15, 2017: Materials
https://www.readbyqxmd.com/read/29244531/effects-of-natural-peptides-from-food-proteins-on-angiotensin-converting-enzyme-activity-and-hypertension
#2
Melanie Martin, Andreas Deussen
Cardiovascular diseases are the leading cause of death. The underlying pathophysiology is largely contributed by an overactivation of the renin-angiotensin-aldosterone-system (RAAS). Herein, angiotensin II (AngII) is a key mediator not only in blood pressure control and vascular tone regulation, but also involved in inflammation, endothelial dysfunction, atherosclerosis, hypertension and congestive heart failure. Since more than three decades suppression of AngII generation by inhibition of the angiotensin-converting enzyme (ACE) or blockade of the AngII-receptor has shown clinical benefit by reducing hypertension, atherosclerosis and other inflammation-associated cardiovascular diseases...
December 15, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29243277/purification-of-angiotensin-converting-enzyme-from-human-plasma-and-investigation-of-the-effect-of-some-active-ingredients-isolated-from-nigella-sativa-l-extract-on-the-enzyme-activity
#3
Zehra Basi, Vedat Turkoglu
In the present study, one-step purification of angiotensin converting enzyme (ACE, peptidyldipeptidase A, EC 3.4.15.1), responsible from regulation of blood pressure, was achieved using affinity chromatography from human plasma. The enzyme was purified 12860-fold with a spesific activtiy of 5080 EU/mg.protein. Optimum temperature and pH were determined for the enzyme as 35-40 °C and pH 7.4-7.5, respectively. The purity of ACE was determined by SDS-PAGE and the enzyme showed two bands at 60 kDa and 70 kDa on the gel...
December 15, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29241979/acalabrutinib-in-relapsed-or-refractory-mantle-cell-lymphoma-ace-ly-004-a-single-arm-multicentre-phase-2-trial
#4
Michael Wang, Simon Rule, Pier Luigi Zinzani, Andre Goy, Olivier Casasnovas, Stephen D Smith, Gandhi Damaj, Jeanette Doorduijn, Thierry Lamy, Franck Morschhauser, Carlos Panizo, Bijal Shah, Andrew Davies, Richard Eek, Jehan Dupuis, Eric Jacobsen, Arnon P Kater, Steven Le Gouill, Lucie Oberic, Taduesz Robak, Todd Covey, Richa Dua, Ahmed Hamdy, Xin Huang, Raquel Izumi, Priti Patel, Wayne Rothbaum, J Greg Slatter, Wojciech Jurczak
BACKGROUND: Bruton tyrosine kinase is a clinically validated target in mantle cell lymphoma. Acalabrutinib (ACP-196) is a highly selective, potent Bruton tyrosine kinase inhibitor developed to minimise off-target activity. METHODS: In this open-label, phase 2 study, oral acalabrutinib (100 mg twice per day) was given to patients with relapsed or refractory mantle cell lymphoma, until disease progression or unacceptable toxicity. The primary endpoint was overall response assessed according to the Lugano classification, and safety analyses were done in all participants...
December 11, 2017: Lancet
https://www.readbyqxmd.com/read/29241767/effects-of-prolonged-exposure-to-moderate-static-magnetic-field-and-its-synergistic-effects-with-alkaline-ph-on-enterococcus-faecalis
#5
Wei Fan, Zhuo Huang, Bing Fan
Static magnetic field (SMF) has been shown to biologically affect various microorganisms, but its effects on Enterococcus faecalis, which is associated with multiple dental infections, have not been reported yet. Besides, Enterococcus faecalis was found to be resistant to the alkaline environment provided by a major dental antimicrobial, calcium hydroxide. Therefore, the antibacterial activity of prolonged exposure to moderate SMF (170 mT) and its possible synergistic activity with alkaline pH (pH = 9) were evaluated in the study...
December 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29241309/involvement-of-endothelial-nitric-oxide-synthase-activation-in-midkine-mediated-central-hypotensive-effects
#6
Ching-Huang Lin, Jun-Yen Pan, Jung-Jui Chang, Hsin-Hung Chen, Pei-Wen Cheng, Ching-Jiunn Tseng
The growth factor midkine has been implicated in various biologic and pathologic events. It has been shown that the peripheral influence of midkine on cardiovascular regulation is due to an influence on the renin-angiotensin system. The nucleus tractus solitarii (NTS) is the primary integrative center for cardiovascular control and other autonomic functions in the central nervous system. However, the signaling mechanisms involved in midkine-mediated cardiovascular effects in the NTS remain unclear. In this study, we investigated whether the renin-angiotensin system and/ or N-methyl-D-aspartate (NMDA) receptor-calmodulin-eNOS signaling pathways were both involved in midkine-mediated blood pressure (BP) regulation in the NTS of Wistar-Kyoto rats...
December 15, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29241088/development-of-an-lc-ms-method-to-quantify-coproporphyrin-i-and-iii-as-endogenous-biomarkers-for-drug-transporter-mediated-drug-drug-interactions
#7
Emmanuel Njumbe Ediage, Lieve Dillen, Ann Vroman, Luc Diels, Annett Kunze, Jan Snoeys, Tom Verhaeghe
Coproporphyrins are proposed as endogenous biomarkers of hepatic Organic Anion Transporting Polypeptide (OATP)1B functional activity. In this study, a new sample extraction method based on a mixed-mode anion exchange sorbent (SPE clean-up using Oasis 30mg Max 96 well plates) was developed for absolute quantification of coproporphyrin I and III (CP-I and CP-III) in human plasma. Chromatographic separation was performed with an Ace Excel 2 C18 PFP, 3μm, 2.1×150mm, maintained at 60°C. A 10mM ammonium formate containing 0...
December 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29239813/experimental-assessment-of-the-advanced-collapsed-cone-engine-for-scalp-brachytherapy-treatments
#8
Brie Cawston-Grant, Hali Morrison, Ron S Sloboda, Geetha Menon
PURPOSE: To experimentally assess the performance of the Advanced Collapsed-cone Engine (ACE) for 192Ir high-dose-rate brachytherapy treatment planning of nonmelanoma skin cancers of the scalp. METHODS AND MATERIALS: A layered slab phantom was designed to model the head (skin, skull, and brain) and surface treatment mold using tissue equivalent materials. Six variations of the phantom were created by varying skin thickness, skull thickness, and size of air gap between the mold and skin...
November 24, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29238804/efficacy-of-high-sensitivity-troponin-t-in-identifying-very-low-risk-patients-with-possible-acute-coronary-syndrome
#9
W Frank Peacock, Brigette M Baumann, Deborah Bruton, Thomas E Davis, Beverly Handy, Christopher W Jones, Judd E Hollander, Alexander T Limkakeng, Abhi Mehrotra, Martin Than, Andre Ziegler, Carina Dinkel
Importance: Physicians need information on how to use the first available high-sensitivity troponin (hsTnT) assay in the United States to identify patients at very low risk for 30-day adverse cardiac events (ACE). Objective: To determine whether a negative hsTnT assay at 0 and 3 hours following emergency department presentation could identify patients at less than 1% risk of a 30-day ACE. Design, Setting, and Participants: A prospective, observational study at 15 emergency departments in the United States between 2011 and 2015 that included individuals 21 years and older, presenting to the emergency department with suspected acute coronary syndrome...
December 13, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29238257/validation-of-an-arm-crank-ergometer-test-for-use-in-sedentary-adults
#10
Alexandros Mitropoulos, Anil Gumber, Helen Crank, Markos Klonizakis
The maximal oxygen uptake (V̇O2peak) test is an approved pre-operative examination tool, in a clinical setting: Both V̇O2peak and anaerobic threshold indicate a patient's physiological tolerance for major surgery and post-operative mortality, with cycle ergometry being routinely used for V̇O2peak tests in clinical settings, in many European countries. Nevertheless, the opportunities to assess populations with restricted mobility of the lower limbs are limited, as alternative methods (such as an arm-crank test protocol) to assess V̇O2peak are yet to be established...
December 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29237475/recombinant-human-ace2-acing-out-angiotensin-ii-in-ards-therapy
#11
EDITORIAL
Haibo Zhang, Andrew Baker
No abstract text is available yet for this article.
December 13, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29236035/short-communication-a-comparison-of-the-in-vitro-angiotensin-1-converting-enzyme-inhibitory-capacity-of-dairy-and-plant-protein-supplements
#12
Carlotta Giromini, Ágnes A Fekete, D Ian Givens, Antonella Baldi, Julie A Lovegrove
The consumption of supplements based on dairy or plant proteins may be associated with bioactive potential, including angiotensin-1-converting enzyme inhibitory (ACE-1i) activity, which is linked with blood pressure reduction in vivo. To gain insight into this proposed mechanism, the ACE-1i potential of protein-based supplements, including a selection of dairy (n = 10) and plant (n = 5) proteins were in vitro digested. The total digest was filtered and permeate and retentate were obtained. ACE-1i activity was measured as the ability of proteins (pre-digestion, 'gastric', permeate, and retentate) to decrease the hydrolysis of furanacroloyl-Phe-Glu-Glu (FAPGG) substrate for the ACE-1 enzyme...
December 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29234397/artemisia-iwayomogi-plus-curcuma-longa-synergistically-ameliorates-nonalcoholic-steatohepatitis-in-hepg2-cells
#13
Hyeong-Geug Kim, Sung-Bae Lee, Jin-Seok Lee, Won-Young Kim, Seung-Hoon Choi, Chang-Gue Son
The combination of Artemisia iwayomogi and Curcuma longa radix is frequently prescribed for liver diseases in TKM. However, the synergic effects of the two herbs on nonalcoholic steatohepatitis (NASH) have not yet been studied. Therefore, we investigated the anti-NASH effects of the water extract of A. iwayomogi (AI), C. longa radix (CL), and combination of the two herbs (ACE). Hepatic steatosis and NASH were induced in HepG2 cells by treatment with palmitic acid (PA, for 6 h) with/without pretreatment of ACE (25 or 50 μg/mL), AI (50 or 100 μg/mL), CL (50 or 100 μg/mL), curcumin (5 μg/mL), or scopoletin (5 μg/mL)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234376/roles-of-nitric-oxide-and-prostaglandins-in-the-sustained-antihypertensive-effects-of-acanthospermum-hispidum-dc-on-ovariectomized-rats-with-renovascular-hypertension
#14
Rhanany Alan Calloi Palozi, Maysa Isernhagen Schaedler, Cleide Adriane Signor Tirloni, Aniely Oliveira Silva, Francislaine Aparecida Dos Reis Lívero, Roosevelt Isaias Carvalho Souza, Ariany Carvalho Dos Santos, Thiago Bruno Lima Prando, Lauro Mera de Souza, Arquimedes Gasparotto Junior
Although Acanthospermum hispidum is used in Brazilian folk medicine as an antihypertensive, no study evaluated its effects on a renovascular hypertension and ovariectomy model. So, this study investigated the mechanisms involved in the antihypertensive effects of an ethanol-soluble fraction obtained from A. hispidum (ESAH) using two-kidney-one-clip hypertension in ovariectomized rats (2K1C plus OVT). ESAH was orally administered at doses of 30, 100, and 300 mg/kg, daily, for 28 days, after 5 weeks of surgery...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29232407/temporal-changes-in-cardiac-oxidative-stress-inflammation-and-remodeling-induced-by-exercise-in-hypertension-role-for-local-angiotensin-ii-reduction
#15
Sebastião D Silva, Zaira P Jara, Roseli Peres, Larissa S Lima, Cristóforo Scavone, Augusto C Montezano, Rhian M Touyz, Dulce E Casarini, Lisete C Michelini
Exercise training reduces renin-angiotensin system (RAS) activation, decreases plasma and tissue oxidative stress and inflammation in hypertension. However, the temporal nature of these phenomena in response to exercise is unknown. We sought to determine in spontaneously hypertensive rats (SHR) and age-matched WKY controls the weekly effects of training on blood pressure (BP), plasma and left ventricle (LV) Ang II and Ang-(1-7) content (HPLC), LV oxidative stress (DHE staining), gene and protein expression (qPCR and WB) of pro-inflammatory cytokines, antioxidant enzymes and their consequence on hypertension-induced cardiac remodeling...
2017: PloS One
https://www.readbyqxmd.com/read/29231917/stable-coronary-artery-disease-medical-treatment
#16
REVIEW
Rafał Dąbrowski, Marcin Dobrowolski
The crucial issues in optimal medical therapy to improve prognosis and reduce angina symptoms are secondary prevention, effective control of concomitant diseases, risk factors and medical treatment. In spite of successful percutaneous coronary interventions (PCI) and medical treatment with beta-blockers, ACE-inhibitors or angiotensin receptor blockers, statins and antiplatelet drugs, some patients are still symptomatic. In the era of PCI not sufficient attention is paid to other drugs reducing the incidence of angina episodes: calcium antagonists, long-acting nitrates, metabolic agents and novel antianginal drugs...
November 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29230902/the-evolutionary-fate-of-heterogeneous-gene-duplications-a-precarious-overdominant-equilibrium-between-environment-sublethality-and-complementation
#17
Pascal Milesi, Benoît S Assogba, Célestine M Atyame, Nicolas Pocquet, Arnaud Berthomieu, Sandra Unal, Patrick Makoundou, Mylène Weill, Pierrick Labbé
Gene duplications occur at a high rate. Although most appear detrimental, some homogeneous duplications (identical gene copies) can be selected for beneficial increase in produced proteins. Heterogeneous duplications, which combine divergent alleles of a single locus, are seldom studied due to the paucity of empirical data. We investigated their role in an ongoing adaptive process at the ace-1 locus in Culex pipiens mosquitoes. We assessed the worldwide diversity of the ace-1 alleles (single-copy, susceptible S and insecticide-resistant R, and duplicated D that pair one S and one R copy), analyzed their phylogeography, and measured their fitness to understand their early dynamics using population genetics models...
December 12, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/29229112/disease-marker-combination-enhances-patient-characterization-in-the-finnish-sarcoidosis-patients
#18
E Lahtela, A Wolin, A Pietinalho, M-L Lokki, O Selroos
Sarcoidosis is an inflammatory disease of unknown etiology and multiple clinical phenotypes. Clinical manifestations range from asymptomatic disease to severe loss-of-function leading to the hypothesis that sarcoidosis might not be just one disease, but consists of several distinct disease entities each with potentially distinct genetic associations. We have previously demonstrated that in our series HLADRB1* 03:01 and haplotype HLA-DRB1*04:01-DPB1*04:01 are associated with good prognosis sarcoidosis. In our recent work, we found a novel SNP (rs9905945) in the 5'upstream region of the ACE gene to be associated with favorable disease prognosis as well...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29229013/attachment-security-moderates-the-link-between-adverse-childhood-experiences-and-cellular-aging
#19
Or Dagan, Arun Asok, Howard Steele, Miriam Steele, Kristin Bernard
Exposure to childhood adversity has been linked to accelerated telomere shortening, a marker of cellular aging and an indicator of physical health risk. In the current study, we examined whether adult attachment representation moderated the association between childhood adversity and telomere length. Participants included 78 young adults (M age = 20.46, SD = 1.57), who reported on their exposure to adverse childhood experiences (ACE) and were administered the Adult Attachment Interview, which was coded for attachment state of mind...
December 12, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29228591/up-regulation-of-angiotensin-converting-enzyme-in-response-to-acute-ischemic-stroke-via-erk-nf-%C3%AE%C2%BAb-pathway-in-spontaneously-hypertensive-rats
#20
Zhou Ou, Meng-Xing Tao, Qing Gao, Xue-Ling Zhang, Yang Yang, Jun-Shan Zhou, Ying-Dong Zhang
Cerebral ischemic stroke is usually caused by a temporary or permanent decrease in blood supply to the brain. Despite general progress in diagnosis and treatment, the prognosis of stroke is still unsatisfactory, and more detailed potential mechanisms are needed to investigate underlying the pathological process. Here, we showed that serum angiotensin-converting enzyme (ACE) concentration was positively correlated with infarct volume after acute ischemic stroke (AIS). Moreover, using a permanent middle cerebral artery occlusion rat model, we indicated for the first time that increased ACE expression in response to AIS was regulated by the ERK/NF-κB pathway in peri-infarct regions...
November 14, 2017: Oncotarget
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