Wei Zhang, Shiqin Zhuo, Long He, Cheng Cheng, Bo Zhu, Yin Lu, Qinan Wu, Wenbin Shang, Weihong Ge, Liyun Shi
The bacterial pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA) is a potentially fatal disease, featured with extensive infection, inflammation, and airway dysfunction. With the increasing emerging of drug-resistant strains, new therapeutic strategies beyond canonical antibiotic treatment are pressingly needed. Daphnetin (DAPH) is a natural coumarin derivative with anti-inflammation, anti-microorganism and anti-oxidative properties. However, the protective effect of DAPH on S. aureus-caused pneumonia and the mechanism involved are never explored...
April 13, 2019: International Immunopharmacology