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https://www.readbyqxmd.com/read/29455885/vincristine-resistance-in-relapsed-neuroblastoma-can-be-efficiently-overcome-by-smac-mimetic-lcl161-treatment
#1
Kristin Frommann, Birgit Appl, Patrick Hundsdoerfer, Konrad Reinshagen, Georg Eschenburg
PURPOSE: In spite of good initial therapy response neuroblastomas often spread to distant organs or relapse after periods of remission. Dysregulation of apoptosis, a hallmark of cancer, is often effected by elevated levels of antiapoptotic signals leading to resistance against chemotherapeutic drugs. Inhibitors of apoptosis proteins (IAPs) are crucial cellular apoptosis regulators. Targeting IAPs with Smac mimetics has been demonstrated as a promising strategy for treatment of neuroblastoma and other tumors...
January 31, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29455078/a-supersensitive-silver-nanoprobe-based-aptasensor-for-low-cost-detection-of-malathion-residues-in-water-and-food-samples
#2
Rajni Bala, Sherry Mittal, Rohit K Sharma, Nishima Wangoo
In the present study, we report a highly sensitive, rapid and low cost colorimetric monitoring of malathion (an organophosphate insecticide) employing a basic hexapeptide, malathion specific aptamer (oligonucleotide) and silver nanoparticles (AgNPs) as a nanoprobe. AgNPs are made to interact with the aptamer and peptide to give different optical responses depending upon the presence or absence of malathion. The nanoparticles remain yellow in color in the absence of malathion owing to the binding of aptamer with peptide which otherwise tends to aggregate the particles because of charge based interactions...
February 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29454308/the-unique-evolutionary-pattern-of-the-hydroxyproline-rich-glycoproteins-superfamily-in-chinese-white-pear-pyrus-bretschneideri
#3
Huijun Jiao, Xing Liu, Shuguang Sun, Peng Wang, Xin Qiao, Jiaming Li, Chao Tang, Juyou Wu, Shaoling Zhang, Shutian Tao
BACKGROUND: The hydroxyproline-rich glycoprotein (HRGP) superfamily, comprising three families (arabinogalactan-proteins, AGPs; extensins, EXTs; proline-rich proteins, PRPs), is a class of proline-rich proteins that exhibit high diversity and are involved in many aspects of plant biology. RESULTS: In this study, 838 HRGPs were identified from Chinese white pear (Pyrus bretschneideri) by searching for biased amino acid composition and conserved motifs. 405 HRGPs were derived from whole genome duplication (WGD) events which is suggested to be the major force of driving HRGPs expansion and the recent WGD event shared by apple and pear generated most duplicated HRGPs in pear...
February 17, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29453173/land-use-change-impacts-on-the-amount-and-quality-of-recharge-water-in-the-loess-tablelands-of-china
#4
Yanan Huang, Qingrui Chang, Zhi Li
Exploring how land use change (LUC) influences the amount and quality of recharge water is important for groundwater sustainability and land use planning. With loess of up to 200m in thickness and unsaturated zones up to 100m below the surface, the loess tablelands in China can store abundant groundwater resources. However, groundwater depletion and substantial LUC have been simultaneously observed. It is thus necessary to investigate the relationship between LUC and groundwater. We sampled 10-m soil profiles for three land use types (farmlands, apple orchards of 10 and 20years old)...
February 13, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29452235/improved-strength-of-silk-fibers-in-bombyx-mori-trimolters-induced-by-an-anti-juvenile-hormone-compound
#5
Kaiyu Guo, Zhaoming Dong, Yan Zhang, Dandan Wang, Muya Tang, Xiaolu Zhang, Qingyou Xia, Ping Zhao
BACKGROUND: Bombyx mori silk fibers with thin diameters have advantages of lightness and crease-resistance. Many studies have used anti-juvenile hormones to induce trimolters in order to generate thin silk; however, there has been comparatively little analysis of the morphology, structure and mechanical properties of trimolter silk. METHODS: This study induced two kinds of trimolters by appling topically anti-juvenile hormones and obtained thin diameter silk. Scanning electron microscope (SEM), FTIR analysis, tensile mechanical testing, chitin staining were used to reveal that the morphology, conformation and mechanical property of the trimolter silk...
February 13, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29451714/development-of-regenerative-and-flexible-fibroin-based-wound-dressings
#6
Angelica Panico, Federica Paladini, Mauro Pollini
Skin injuries represent a health problem with consequences in terms of morbidity, disability and life quality. Numerous strategies have been developed for the treatment of wounds, including skin substitutes, biomembranes, scaffolds, and smart dressings. The excellent properties of fibroin can be exploited for the development of advanced wound dressing biomaterials, aiming at promoting the wound healing process. In this work, silk fibroin films modified through the addition of glucose were developed to enhance flexibility of medical device without affecting the biocompatibility, to promote wound healing and to improve the patient well-being...
February 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29451708/promotion-of-bone-regeneration-on-titanium-implants-through-a-chemical-treatment-process-using-calcium-phosphate-slurry-microscopic-analysis-cellular-response-and-animal-experiment
#7
Tatsuro Ito, Naofumi Ohtsu, Masanari Tomozawa, Mitsuhiro Hirano, Hiroko Takita, Tadashi Iizuka, Atsuro Yokoyama
The present study provides scientific evidence that a new chemical treatment process using calcium phosphate slurry promotes bone regeneration on titanium (Ti) implants. The material's surface modified by the treatment was analyzed using microscopic observation and the bone regeneration efficacy was evaluated both in vitro and in vivo. Formation of a thin hydroxyapatite layer with a thickness of about 50 nm and an increase of surface roughness were confirmed by microscopic observations. Histological evaluation of rat femora implanted with the specimens showed that the areas of the specimens directly attached to bone tissue were significantly more extensive than those implanted with control Ti at 2 and 8 weeks...
February 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29449885/deep-eutectic-solvents-pretreatment-of-agro-industrial-food-waste
#8
Alessandra Procentese, Francesca Raganati, Giuseppe Olivieri, Maria Elena Russo, Lars Rehmann, Antonio Marzocchella
Background: Waste biomass from agro-food industries are a reliable and readily exploitable resource. From the circular economy point of view, direct residues from these industries exploited for production of fuel/chemicals is a winning issue, because it reduces the environmental/cost impact and improves the eco-sustainability of productions. Results: The present paper reports recent results of deep eutectic solvent (DES) pretreatment on a selected group of the agro-industrial food wastes (AFWs) produced in Europe...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29448471/generation-of-anisotropy-in-turbulent-flows-subjected-to-rapid-distortion
#9
Timothy T Clark, Susan Kurien, Robert Rubinstein
A computational tool for the anisotropic time-evolution of the spectral velocity correlation tensor is presented. We operate in the linear, rapid distortion limit of the mean-field-coupled equations. Each term of the equations is written in the form of an expansion to arbitrary order in the basis of irreducible representations of the SO(3) symmetry group. The computational algorithm for this calculation solves a system of coupled equations for the scalar weights of each generated anisotropic mode. The analysis demonstrates that rapid distortion rapidly but systematically generates higher-order anisotropic modes...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29448155/characterization-of-a-superman-like-gene-mdsup11-in-apple-malus-%C3%A3-domestica-borkh
#10
Ke Xu, LiMin Wang, Na Liu, Xuan Xie, YuanDi Zhu
Arabidopsis SUPERMAN and its family members of its family play important roles in plant growth and floral organ development; yet much less is known about their functions expanding in apple tree development. Previous work has identified 12 SUP-like genes in the apple (Malus × domestica Borkh.) genome, and the MdSUP11 which is expressed in both vegetative and reproductive organs of apple. However, the function of MdSUP11 remains obscure. In this study, the β-glucuronidase expression driven by the MdSUP11 native promoter was detected in roots, young leaves, and floral organs of transgenic Arabidopsis...
December 6, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29446827/effect-of-ultrasound-dielectric-pretreatment-on-the-oxidation-resistance-of-vacuum-fried-apple-chips
#11
Xu Shen, Min Zhang, Bhesh Bhandari, Zhimei Guo
BACKGROUND: In order to investigate ultrasound dielectric pretreatment effect on oxidation resistance of vacuum fried apple chips, apple slices were pretreated at ultrasonic power for 150, 250 and 400 W and time for 10, 20 and, 30 min, followed by vacuum frying (VF) . The quality and oxidation resistance of fried apple were evaluated by testing the dielectric properties and comparing moisture content, oil uptake, color, acid value (AV) and peroxide value (PV) of apple chips. RESULTS: Ultrasonic treatment can significantly change dielectric properties of apple slices...
February 15, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29446542/novel-calcitonin-gene-related-peptide-chitosan-strontium-calcium-phosphate-cement-enhanced-proliferation-of-human-umbilical-vein-endothelial-cells-in-vitro
#12
Tiancheng Lv, Wei Liang, Li Li, Xu Cui, Xiaomou Wei, Haobo Pan, Bing Li
Bone cement materials have some disadvantages, including slow degradation and no biological activity, which greatly weakens their clinical application. Therefore, the search for a multifunctional bioactive bone cement has become urgent. In this study, a novel bone cement sample of calcitonin gene-related peptide (CGRP)/chitosan-strontium (Sr)-calcium phosphate cement (CPC) was developed. The structure and morphology were observed by scanning electron microscope (SEM). The cytotoxicity and proliferation of CGRP/chitosan-Sr-CPC were also measured...
February 15, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29446476/the-role-of-human-papillomavirus-in-laryngeal-cancer-in-southern-china
#13
Eddy Wh Lam, Michael Mh Chan, Cynthia Kc Wai, Chi Man Ngai, Zigui Chen, Martin Cs Wong, Apple Cm Yeung, Joanna Hm Tong, Amy Bw Chan, K F To, Paul Ks Chan
Objective Delineate the role of human papillomavirus (HPV) in laryngeal cancer in Southern Chinese. Study Design A retrospective cross-sectional study. Setting A major otorhinolaryngology referral center in Hong Kong. Subjects and Methods Eighty-five Chinese patients with histology-confirmed laryngeal squamous cell carcinoma (LSCC) diagnosed between 2005 and 2010 were examined for the status of HPV by PCR, and the expression of p16 and p53 by immunohistochemistry. The HPV, p16 and p53 findings were correlated with clinicopathological features, recurrence and 5-year survival...
February 15, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29444206/grimmiaceae-in-the-early-cretaceous-tricarinella-crassiphylla-gen-et-sp-nov-and-the-value-of-anatomically-preserved-bryophytes
#14
Adolfina Savoretti, Alexander C Bippus, Ruth A Stockey, Gar W Rothwell, Alexandru M F Tomescu
Background and Aims: Widespread and diverse in modern ecosystems, mosses are rare in the fossil record, especially in pre-Cenozoic rocks. Furthermore, most pre-Cenozoic mosses are known from compression fossils, which lack detailed anatomical information. When preserved, anatomy significantly improves resolution in the systematic placement of fossils. Lower Cretaceous (Valanginian) deposits on Vancouver Island (British Columbia, Canada) contain a diverse anatomically preserved flora including numerous bryophytes, many of which have yet to be characterized...
February 10, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29442931/anti-oxidative-and-antibacterial-self-healing-edible-polyelectrolyte-multilayer-film-in-fresh-cut-fruits
#15
Xuefan Liu, Wei Han, Yanxi Zhu, Hongyun Xuan, Jiaoyu Ren, Jianhao Zhang, Liqin Ge
The consumption of fresh-cut fruits is limited because of the oxidation browning and pathogenic bacteria's growth on the fruit surface. Besides, crack of the fresh-keeping film may shorten the preservation time of fruit. In this work, polyelectrolyte multilayer (PEM) film was fabricated by layer-by-layer (LBL) electrostatic deposition method. The film was made by carboxy methylcellulose sodium (CMC) and chitosan (CS). The as-prepared PEM film had good anti-oxidative and antibacterial capability. It inhibited the growth of Gram-negative bacteria and the antibacterial rate was more than 95%...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442670/redox-state-detection-of-fruits-and-vegetables-by-a-simple-surface-enhanced-raman-scattering-method
#16
Jie Sun, Jian Dong, Shuyan Han, Ying Wang, Qingran Yang, Weiping Qian
In order to detect the redox states of fruits and vegetables simply, a SERS (surface-enhanced Raman scattering) method was developed based on a redox-sensitive probe and a pH-sensitive probe. The two probes were dropped onto the flesh of the fresh incision of fruits and vegetables, respectively. The SERS spectra of redox-sensitive probes were used to indicate their redox states, and the SERS spectra of pH-sensitive probes were used to indicate their pH values to discount the influence of pH on the redox states...
July 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442163/accuracy-and-feasibility-of-a-dedicated-image-guidance-solution-for-endoscopic-lateral-skull-base-surgery
#17
Christoph Rathgeb, Lukas Anschuetz, Daniel Schneider, Cilgia Dür, Marco Caversaccio, Stefan Weber, Tom Williamson
OBJECTIVE: We aimed to design, build and validate a surgical navigation system which fulfills the accuracy requirements for surgical procedures on the ear and the lateral skull base, and which integrates with the endoscopic workflow and operating room setup. MATERIALS AND METHODS: The navigation system consists of portable tablet computer (iPad Pro, Apple Computer, USA) and an optical tracking system (Cambar B1, Axios3D, Germany), both connected via a wireless Bluetooth link and attached directly to the OR table...
February 13, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29440593/the-glucose-sensor-mdhxk1-phosphorylates-a-tonoplast-na-h-exchanger-to-improve-salt-tolerance
#18
Mei-Hong Sun, Qi-Jun Ma, Da-Gang Hu, Xiao-Ping Zhu, Chun-Xiang You, Huai-Rui Shu, Yu-Jin Hao
Glucose regulates many vital processes, including plant growth, development, metabolism, and responses to biotic and abiotic stress. However, the molecular mechanism by which glucose acts as a signal to regulate salinity tolerance remains unclear. In this study, we found that the apple (Malus domestica Borkh) glucose sensor hexokinase1 (MdHXK1) contributes to glucose-mediated salinity tolerance. A combination of split ubiquitin system, pull-down, Co-IP and BiFC assays demonstrated that MdHXK1 interacts with and phosphorylates the Na+/H+ exchanger MdNHX1 at its Ser275 residue...
February 12, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29438339/measuring-device-for-air-speed-in-macroporous-media-and-its-application-inside-apple-storage-bins
#19
Martin Geyer, Ulrike Praeger, Ingo Truppel, Holger Scaar, Daniel A Neuwald, Reiner Jedermann, Klaus Gottschalk
In cold storage facilities of fruit and vegetables, airflow is necessary for heat removal. The design of storage facilities influences the air speed in the surrounding of the product. Therefore, knowledge about airflow next to the product is important to plan the layout of cold stores adapted to the requirements of the products. A new sensing device (ASL, Air speed logger) is developed for omnidirectional measurement of air speed between fruit or vegetables inside storage bins or in bulk. It consists of four interconnected plastic spheres with 80 mm diameter each, adapted to the size of apple fruit...
February 13, 2018: Sensors
https://www.readbyqxmd.com/read/29437284/formation-of-osteon-like-structures-in-unidirectional-porous-hydroxyapatite-substitute
#20
Takeshi Makihara, Masataka Sakane, Hiroshi Noguchi, Toshinori Tsukanishi, Yasushi Suetsugu, Masashi Yamazaki
Unidirectional porous hydroxyapatite (UDPHAp) bone substitute comprises a microstructure of cross-sectionally oval pores with diameters ranging from 30 to 300 µm. Bone remodeling within the UDPHAp is expected upon implantation into bone; however, the mechanism and factors influencing this bone growth remain unclear. The objectives of the present study were to assess the vasculature and microstructure of newly formed bone and to determine how bone formation is affected by load transfer and UDPHAp pore size...
February 13, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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