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https://www.readbyqxmd.com/read/29161674/deep-brain-stimulation-of-the-subcallosal-cingulate-gyrus-in-patients-with-treatment-resistant-depression-a-double-blinded-randomized-controlled-study-and-long-term-follow-up-in-eight-patients
#1
Angela Merkl, Sabine Aust, Gerd-Helge Schneider, Veerle Visser-Vandewalle, Andreas Horn, Andrea A Kühn, Jens Kuhn, Malek Bajbouj
BACKGROUND: Deep brain stimulation (DBS) of the subcallosal cingulate gyrus (SCG) is an experimental approach in treatment-resistant depression (TRD). Short-term results of efficacy in DBS are incongruent and studies investigating long-term effects are warranted. METHODS: We assessed efficacy of SCG-DBS in eight patients randomized into a delayed-onset group (sham-DBS four weeks) and a non-delayed-onset group. The primary outcome measure was improvement on the Hamilton Depression Rating-Scale (HAMD-24-item-version)...
November 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29161590/skin-and-its-regenerative-powers-an-alliance-between-stem-cells-and-their-niche
#2
REVIEW
Kevin Andrew Uy Gonzales, Elaine Fuchs
Tissues have a natural capacity to replace dying cells and to heal wounds. This ability resides in resident stem cells, which self-renew, preserve, and repair their tissue during homeostasis and following injury. The skin epidermis and its appendages are subjected to daily assaults from the external environment. A high demand is placed on renewal and regeneration of the skin's barrier in order to protect the body from infection and dehydration and to heal wounds. This review focuses on the epithelial stem cells of skin, where they come from, where they reside, and how they function in normal homeostasis and wound repair...
November 20, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29161521/lessons-from-the-camden-coalition-of-healthcare-providers-first-medicaid-shared-savings-performance-evaluation
#3
Aaron Truchil, Natasha Dravid, Stephen Singer, Zachary Martinez, Teagan Kuruna, Scott Waulters
Accountable Care Organizations (ACOs) aim to reduce health care costs while improving patient outcomes. Camden Coalition of Healthcare Providers' (Camden Coalition) work already aligned with this aim before receiving state approval to operate a certified Medicaid ACO in New Jersey. Upon its formation, the Camden Coalition ACO partnered with UnitedHealthcare and, through state legislation, Rutgers Center for State Health Policy (CSHP) was established as its external evaluator. In evaluating the Camden Coalition ACO, Rutgers CSHP built on the Medicare Shared Savings model, but modified it based on the understanding that the Medicaid population differs from the Medicare population...
November 21, 2017: Population Health Management
https://www.readbyqxmd.com/read/29161513/insights-into-molecular-basis-of-acute-contact-toxicity-of-diverse-organic-chemical-in-honey-bee
#4
Xiao Li, Yuan Zhang, Hongna Chen, Huanhuan Li, Yong Zhao
The chemical pollutants, including pesticides and other industrial chemicals, have resulted in significant risks to the whole ecosystem. Therefore, the ecological risk assessment of chemicals is vital and necessary. Since honey bee (Apis mellifera) is probably among the most exposed species to the polluting chemicals, we focused on the in silico estimation of honey bee toxicity (HBT) of chemical and the analysis of the relevance of chemical HBT and several key physical-chemical properties and structural characteristics...
November 21, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29161469/validation-of-a-definition-for-flare-in-patients-with-established-gout
#5
Angelo L Gaffo, Nicola Dalbeth, Kenneth G Saag, Jasvinder A Singh, Elizabeth J Rahn, Amy S Mudano, Yi-Hsing Chen, Ching-Tsai Lin, Sandra Bourke, Worawit Louthrenoo, Janitzia Vazquez-Mellado, Hansel Hernández-Llinas, Tuhina Neogi, Ana Beatriz Vargas-Santos, Geraldo da Rocha Castelar-Pinheiro, Rodrigo B C Amorim, Till Uhlig, Hilde B Hammer, Maxim Eliseev, Fernando Perez-Ruiz, Lorenzo Cavagna, Geraldine M McCarthy, Lisa K Stamp, Martijn Gerritsen, Viktoria Fana, Francisca Sivera, William Taylor
OBJECTIVE: To perform external validation of provisional gout flare (attack) definitions in patients with gout. METHODS: We enrolled 509 participants with gout from 17 international sites in a cross-sectional study performed during routine clinical care and collected data to classify participants as experiencing a gout flare or not according to a provisional definition. A local expert rheumatologist performed the final independent adjudication of the gout flare status...
November 21, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29161335/shoulder-complaints-in-wheelchair-athletes-a-systematic-review
#6
Omar W Heyward, Riemer J K Vegter, Sonja de Groot, Lucas H V van der Woude
BACKGROUND: In recent years the popularity of disabled sports and competition among disabled athletes has grown considerably. With this rise in exposure of, and participation in wheelchair sports comes an increase in related stressors, including musculoskeletal load. External mechanical loading may increase the risk of shoulder complaints. The objective of this literature review was to 1) identify and describe the prevalence and/or incidence of shoulder complaints in wheelchair athletes in the literature, to 2) examine the factors and underlying mechanisms that could be potentially involved, and 3) provide some insights into the development of preventative measures...
2017: PloS One
https://www.readbyqxmd.com/read/29161317/evaluating-architecture-impact-on-system-energy-efficiency
#7
Shijie Yu, Hailong Yang, Rui Wang, Zhongzhi Luan, Depei Qian
As the energy consumption has been surging in an unsustainable way, it is important to understand the impact of existing architecture designs from energy efficiency perspective, which is especially valuable for High Performance Computing (HPC) and datacenter environment hosting tens of thousands of servers. One obstacle hindering the advance of comprehensive evaluation on energy efficiency is the deficient power measuring approach. Most of the energy study relies on either external power meters or power models, both of these two methods contain intrinsic drawbacks in their practical adoption and measuring accuracy...
2017: PloS One
https://www.readbyqxmd.com/read/29161192/patient-preferences-in-subglottic-stenosis-treatment-a-discrete-choice-experiment
#8
Matthew R Naunheim, Margaret L Naunheim, Vinay K Rathi, Ramon A Franco, Mark G Shrime, Phillip C Song
Objectives Subglottic stenosis can be addressed with several different surgical techniques, but patient preferences for these treatment modalities are poorly understood. Economic methods are increasingly being used to understand how patients make decisions. The objective of this pilot study was to assess preferences in subglottic stenosis treatment using patient-centric stated preference techniques. Study Design Discrete choice experiment (DCE). Setting Academic research facility. Subjects and Methods A computer-based DCE was administered in a monitored setting to volunteers from the general population...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29161073/evaluating-public-health-interventions-7-let-the-subject-matter-choose-the-effect-measure-ratio-difference-or-something-else-entirely
#9
Donna Spiegelman, Polyna Khudyakov, Molin Wang, Tyler J Vanderweele
We define measures of effect used in public health evaluations, which include the risk difference and the risk ratio, the population-attributable risk, years of life lost or gained, disability-adjusted life years, quality-adjusted life years, and the incremental cost-effectiveness ratio. Except for the risk ratio, all of these are absolute effect measures. For constructing externally generalizable absolute measures of effect when there is superior fit of the multiplicative model, we suggest using the multiplicative model to estimate relative risks, which will often be obtained in simple linear form with no interactions, and then converting these to the desired absolute measure...
November 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29161045/principles-around-accurate-blood-volume-collection-using-capillary-action
#10
Florian Lapierre, Andrew A Gooley, Michael Breadmore
Capillary action is one mechanism microfluidics uses to draw liquid autonomously in a substrate without the need of external energy. This behaviour can be exploited to collect accurate volumes of liquids such as blood in narrow columns known as capillaries and help the development of inexpensive, user-friendly personalised biomedical tools. Precision bore glass capillaries demonstrate the 'state of the art' for volume accuracy and precision but dimension of height and radius must be carefully chosen in order to exploit the capillary action behaviour efficiently...
November 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29161020/deformation-drives-alignment-of-nanofibers-in-framework-for-inducing-anisotropic-cellulose-hydrogels-with-high-toughness
#11
Dongdong Ye, Qiaoyun Cheng, Qianlei Zhang, Yixiang Wang, Chunyu Chang, Liangbin Li, Haiyan Peng, Lina Zhang
Deformation driven alignment of molecules or nanofibers leading to anisotropy is a challenge in functional soft materials. Here, high toughness hydrogels with deformation-induced anisotropy are fabricated from cellulose solution in LiOH/urea, relying on successively designing a loose chemical crosslinking network and a dense physical network containing nanofibers and submicrobundles formed through parallel self-aggregation in dilute acid. The loose network acts as a large framework, whereas relatively dense physical networks are integrated inside, jointly constituting the hierarchical architecture...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29161010/emerging-approaches-for-spatiotemporal-control-of-targeted-genome-with-inducible-crispr-cas9
#12
Yuta Nihongaki, Takahiro Otabe, Moritoshi Sato
The breakthrough CRISPR (clustered regularly interspaced short palindromic repeats)-Cas9 (CRISPR-associated protein 9) nuclease has revolutionized our ability in genome engineering. Although Cas9 is already a powerful tool for simple and efficient target endogenous gene manipulation, further engineering of Cas9 will improve the performance of Cas9, such as gene-editing efficiency and accuracy in vivo, and expand the application possibility of this Cas9 technology. The emerging inducible Cas9 methods, which can control the activity of Cas9 using an external stimulus such as chemicals and light, have the potential to provide spatiotemporal gene manipulation in user-defined cell population at a specific time and improve the accuracy of Cas9-mediated genome editing...
November 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29160772/crystal-identification-for-a-dual-layer-offset-lyso-based-pet-system-via-lu-176-background-radiation-and-mean-shift-algorithm
#13
Qingyang Wei, Tianyu Ma, Tianpeng Xu, Ming Zeng, Yu Gu, Tiantian Dai, Yaqiang Liu
Modern positron emission tomography (PET) detectors are made from pixelated scintillation crystal arrays and readout by Anger logic. The interaction position of the gamma-ray should be assigned to a crystal using a crystal position map or look-up table. Crystal identification is a critical procedure for pixelated PET systems. In this paper, we propose a novel crystal identification method for a dual-layer-offset LYSO based animal PET system via Lu-176 background radiation and mean shift algorithm. Single photon event data of the Lu-176 background radiation are acquired in list-mode for 3 hours to generate a single photon flood map (SPFM)...
November 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29160725/management-of-neurologic-deformity-of-the-ankle-and-foot-with-concurrent-osteomyelitis-with-the-ilizarov-method
#14
Nikolay Mikhailovich Kliushin, Anatoliy Sergeyevich Sudnitsyn, Koushik Narayan Subramanyam, Jefferson George
BACKGROUND: The combination of neurologic deformity of the ankle and foot with osteomyelitis is a therapeutic challenge. We investigated the role of Ilizarov with regard to eradication of infection, correction of deformities and improvement of patient function. METHODS: We retrospectively reviewed 77 patients (77 feet) with neurologic deformity of the ankle and foot with osteomyelitis treated sequentially in 3 stages by Ilizarov method. The 3 stages were (1) active debridement and Ilizarov stabilization, (2) further strengthening of Ilizarov fixator and active osteosynthesis consisting of strategies like arthrodesis, osteotomy distraction, bone transport, or combination thereof, (3) consolidation of fusion/regeneration achieved in second stage...
November 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/29160718/social-and-leisure-activity-profiles-and-well-being-among-the-older-adults-a-longitudinal-study
#15
Joulain Michèle, Martinent Guillaume, Taliercio Alain, Bailly Nathalie, Ferrand Claude, Gana Kamel
OBJECTIVES: Studies highlight the beneficial effects of social and leisure activities on the well-being of aging people. Our aims were: to investigate activity profiles among older adults living in their own homes, to highlight potential changes in profiles over a period of five years and to examine effects of differences between these profiles on well-being variables. METHODS: Three waves were considered in this longitudinal study, with 550, 410 and 374 people (76, 79, 82 years on average), respectively...
November 21, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/29160703/ruthenium-carbon-rich-group-as-a-redox-switchable-metal-coupling-unit-in-linear-trinuclear-complexes
#16
Emmanuel Di Piazza, Corentin Boilleau, Antoine Vacher, Khalissa Merahi, Lucie Norel, Karine Costuas, Thierry Roisnel, Sylvie Choua, Philippe Turek, Stéphane Rigaut
The preparation and properties of novel ruthenium carbon-rich complexes [(Ph-C≡C-)2-nRu(dppe)2(-C≡C-bipyM(hfac)2)n] (n = 1, 2; M = Cu(II), Mn(II); bipy = 2,2'-bipyridin-5-yl) characterized by single-crystal X-ray diffraction and designed for molecular magnetism are reported. With the help of EPR spectroscopy, we show that the neutral ruthenium system sets up a magnetic coupling between two remote paramagnetic Cu(II) units. More specifically, these copper compounds are unique examples of bimetallic and linear heterotrimetallic compounds for which a complete rationalization of the magnetic interactions could be made for exceptionally long distances between the spin carriers (8...
November 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29160691/bioinspired-tribotronic-resistive-switching-memory-for-self-powered-memorizing-mechanical-stimuli
#17
Yihui Sun, Xin Zheng, Xiaoqin Yan, Qingliang Liao, Shuo Liu, Guangjie Zhang, Yong Li, Yue Zhang
Haptic memory, from the interaction of skin and brain, can not only perceive external stimuli but also memorize it after removing the external stimuli. For the mimicry of human sensory memory, a self-powered artificial tactile memorizing system were developed by coupling bionic electronic skin and nonvolatile RRAM. The tribotronic nanogenerator is utilized as electronic skin to transform the touching signal into electric pulse, which will be programmed into the artificial brain: RRAM. Owing to the advanced structural designs and accurately parameter matching, including the output voltages and the resistances in different resistive states, the artificial brain can be operated at self-powered mode to memorize the touch stimuli with the responsivity up to 2000%...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29160554/digest-evolution-of-sperm-size-and-number-in-external-fertilizers
#18
Pedram Samani
Ejaculate evolution in externally fertilizing species is influenced by competition among sperm as well as the rate at which sperm and eggs encounter one another. Liao et al. (2017) found that ejaculate evolution in external fertilizers depended on spawning conditions. In anurans, gametes are released very close to eggs and are relatively protected from dispersal by water currents, thus sperm competition is more important. However, in fish, sperm-egg encounter rate plays a much more important role in ejaculate evolution because gametes may be easily dispersed when released into the aquatic environment...
November 21, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29160539/prevalence-and-associated-factors-of-external-punctal-stenosis-among-elderly-patients-in-turkey
#19
Mahmut Oğuz Ulusoy, Mehmet Atakan, Sertaç Argun Kıvanç
PURPOSE: To estimate the prevalence of external punctal stenosis (EPS) in the elderly population and investigate associated factors. METHODS: A total of 278 patients ≥65 years of age were evaluated for evidence of EPS from January to July 2016. Associated systemic, ocular, demographic, and lifestyle factors were investigated. Multiple logistic regression analyses were applied to evaluate the factors related to having EPS. P values <0.05 were considered statistically significant...
September 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29160415/interregional-correlations-of-glucose-metabolism-between-the-basal-ganglia-and-different-cortical-areas-an-ultra-high-resolution-pet-mri-fusion-study-using-18f-fdg
#20
J H Kim, Y D Son, J M Kim, H K Kim, Y B Kim, C Lee, C H Oh
Basal ganglia have complex functional connections with the cerebral cortex and are involved in motor control, executive functions of the forebrain, such as the planning of movement, and cognitive behaviors based on their connections. The aim of this study was to provide detailed functional correlation patterns between the basal ganglia and cerebral cortex by conducting an interregional correlation analysis of the 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) data based on precise structural information...
November 13, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
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