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https://www.readbyqxmd.com/read/29786738/design-and-mechanistic-study-of-a-novel-gold-nanocluster-based-drug-delivery-system
#1
Qinzhen Li, Yiting Pan, Tiankai Chen, Yuanxin Du, Honghua Ge, Buchang Zhang, Jianping Xie, Haizhu Yu, Manzhou Zhu
Chemically-triggered drug delivery systems (DDSs) have been extensively studied as they do not require specialized equipment to deliver the drug and can deeply penetrate human tissue. However, their syntheses are complicated and they tend to be cytotoxic, which restricts their clinical utility. In this work, the self-regulated drug loading and release capabilities of peptide-protected gold nanoclusters (Pep-Au NCs) are investigated using vancomycin (Van) as the model drug. Gold nanoclusters (Au NCs) coated with a custom-designed pentapeptide are synthesized as drug delivery nanocarriers and loaded with Van - a spontaneous process reliant on the specific binding between Van and the custom-designed peptide...
May 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29782969/electroencephalographic-and-cardiovascular-markers-of-vulnerability-within-families-of-suicidal-adolescents-a-pilot-study
#2
Erin A Kaufman, Sheila E Crowell, James Coleman, Megan E Puzia, Douglas D Gray, David L Strayer
Suicide, self-injury, and predisposing vulnerabilities aggregate in families. Those at greatest risk often show deficits in two biologically-mediated domains: behavioral control and emotion regulation. This pilot study explored electroencephalographic and cardiovascular indices of self-regulation among typical and suicidal adolescents (n = 30/group) and biological family members (mothers, fathers, and siblings). We measured event-related potentials during a flanker task designed to evoke impulsive responding and respiratory sinus arrhythmia (RSA) at rest and during social rejection...
May 18, 2018: Biological Psychology
https://www.readbyqxmd.com/read/29782312/naturalistic-driving-study-investigating-self-regulation-behavior-in-early-alzheimer-s-disease-a-pilot-study
#3
Laurence Paire-Ficout, Sylviane Lafont, Fanny Conte, Amandine Coquillat, Colette Fabrigoule, Joël Ankri, Frédéric Blanc, Cécilia Gabel, Jean-Luc Novella, Isabella Morrone, Rachid Mahmoudi
BACKGROUND: Because cognitive processes decline in the earliest stages of Alzheimer's disease (AD), the driving abilities are often affected. The naturalistic driving approach is relevant to study the driving habits and behaviors in normal or critical situations in a familiar environment of participants. OBJECTIVE: This pilot study analyzed in-car video recordings of naturalistic driving in patients with early-stage AD and in healthy controls, with a special focus on tactical self-regulation behavior...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29781940/alpha-actinin-3-r577x-polymorphism-influences-muscle-damage-and-hormonal-responses-after-a-soccer-game
#4
Daniel B Coelho, Eduardo M Pimenta, Izinara C Rosse, Christiano Veneroso, Guilherme De Azambuja Pussieldi, Lenice K Becker, Emerson C Oliveira, Maria R S Carvalho, Emerson Silami-Garcia
Coelho, DB, Pimenta, EM, Rosse, IC, Veneroso, C, Pussieldi, GDA, Becker, LK, De Oliveira, EC, Carvalho, MRS, and Silami-Garcia, E. Alpha-actinin-3 R577X polymorphism influences muscle damage and hormonal responses after a soccer game. J Strength Cond Res XX(X): 000-000, 2018-The purpose of this study was to evaluate indicators of muscle damage and hormonal responses after soccer matches and its relation to alpha-actinin-3 (ACTN3) gene expression (XX vs. RR/RX), considering that the R allele produces alpha-actinin-3 and provides greater muscle strength and power...
May 17, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29781830/early-self-regulation-early-self-regulatory-change-and-their-longitudinal-relations-to-adolescents-academic-health-and-mental-well-being-outcomes
#5
Steven J Howard, Kate E Williams
OBJECTIVE: To evaluate the extent to which early self-regulation and early changes in self-regulation are associated with adolescents' academic, health, and mental well-being outcomes. METHODS: Data were collected from 1 of the cohorts in a large dual-cohort cross-sequential study of Australian children. This cohort consisted of a nationally representative data set of 4983 Australian children assessed at 4 to 5 years of age, who were followed longitudinally to 14 to 15 years of age...
May 16, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/29781634/household-chaos-and-family-sleep-during-infants-first-year
#6
Corey J Whitesell, Brian Crosby, Thomas F Anders, Douglas M Teti
Household chaos has been linked with dysregulated family and individual processes. The present study investigated linkages between household chaos and infant and parent sleep, a self-regulated process impacted by individual, social, and environmental factors. Studies of relations between household chaos and child sleep have focused on older children and teenagers, with little attention given to infants or parent sleep. This study examines these relationships using objective measures of household chaos and sleep while controlling for, respectively, maternal emotional availability at bedtime and martial adjustment, in infant and parent sleep...
May 21, 2018: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/29779874/a-gabaergic-feedback-shapes-dopaminergic-input-on-the-drosophila-mushroom-body-to-promote-appetitive-long-term-memory
#7
Alice Pavlowsky, Johann Schor, Pierre-Yves Plaçais, Thomas Preat
Memory consolidation is a crucial step for long-term memory (LTM) storage. However, we still lack a clear picture of how memory consolidation is regulated at the neuronal circuit level. Here, we took advantage of the well-described anatomy of the Drosophila olfactory memory center, the mushroom body (MB), to address this question in the context of appetitive LTM. The MB lobes, which are made by the fascicled axons of the MB intrinsic neurons, are organized into discrete anatomical modules, each covered by the terminals of a defined type of dopaminergic neuron (DAN) and the dendrites of a corresponding type of MB output neuron (MBON)...
May 9, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29779754/introduction-art-and-the-brain-from-pleasure-to-well-being
#8
EDITORIAL
Julia F Christensen, Antoni Gomila
Empirical aesthetics in general, and neuroaesthetics in particular, have been very much influenced by Berlyne's psychobiological program. For him, aesthetic appreciation involved the brain's reward and aversion systems. From this point of view, art constitutes a set of potentially rewarding stimuli. Research has certainly made great advances in understanding how the process of artistic valuation takes places, and which brain circuits are involved in generating the pleasure we obtain from artistic practices, performances, and works...
2018: Progress in Brain Research
https://www.readbyqxmd.com/read/29779460/is-there-really-a-relationship-between-empathy-and-aggression-evidence-from-physiological-and-self-report-measures
#9
Carlos Gantiva, Rocio Cendales, Maite Díaz, Yesenia González
A strong relationship between empathy and aggression has traditionally been argued, but a recent meta-analysis showed that this relationship is surprisingly weak. However, none of the studies that were analyzed in the meta-analysis used physiological measures of empathy to assess differences between aggressive and nonaggressive subjects. The present study evaluated the activity of the corrugator and zygomatic muscles, galvanic skin response, and heart rate response to pictures with different social content in 30 aggressive and 30 nonaggressive subjects...
May 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29779451/mixed-emotions-an-incentive-motivational-model-of-sexual-deviance
#10
Wineke J Smid, Edwin C Wever
Sexual offending behavior is a complex and multifaceted phenomenon. Most existing etiological models describe sexual offending behavior as a variant of offending behavior and mostly include factors referring to disinhibition and sexual deviance. In this article, we argue that there is additional value in describing sexual offending behavior as sexual behavior in terms of an incentive model of sexual motivation. The model describes sexual arousal as an emotion, triggered by a competent stimulus signaling potential reward, and comparable to other emotions coupled with strong bodily reactions...
May 1, 2018: Sexual Abuse: a Journal of Research and Treatment
https://www.readbyqxmd.com/read/29778779/ftld-als-linked-tdp-43-mutations-do-not-alter-tdp-43-s-ability-to-self-regulate-its-expression-in-drosophila
#11
Laetitia Miguel, Tracey Avequin, Marine Pons, Thierry Frébourg, Dominique Campion, Magalie Lecourtois
TDP-43 is a major disease-causing protein in amyotrophic lateral sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). Today, more than 50 missense mutations in the TARDBP/TDP-43 gene have been described in patients with FTLD/ALS. However, the functional consequences of FTLD/ALS-linked TDP-43 mutations are not fully elucidated. In the physiological state, TDP-43 expression is tightly regulated through an autoregulatory negative feedback loop. Maintaining normal TDP-43 protein levels is critical for proper physiological functions of the cells...
May 17, 2018: Brain Research
https://www.readbyqxmd.com/read/29777541/developmental-transactions-between-self-regulation-and-academic-achievement-among-low-income-african-american-and-latino-children
#12
Britain Mills, Nazly Dyer, Daniel Pacheco, Dawn Brinkley, Margaret T Owen, Margaret O Caughy
This study examined the development of emerging self-regulation (SR) skills across the preschool years and relations to academic achievement in kindergarten and first grade. SR skills of 403 low-income African American and Latino children were measured at 2&1/2, 3&1/2, and 5 years (kindergarten). Reading and math skills were measured at 5 and 6 years (first grade) using the Woodcock-Johnson. Transactional relations between SR skills and achievement outcomes were estimated with latent difference score models...
May 19, 2018: Child Development
https://www.readbyqxmd.com/read/29777436/fatigue-related-risk-management-in-the-emergency-department-a-focus-group-study
#13
Pierre Bérastégui, Mathieu Jaspar, Alexandre Ghuysen, Anne-Sophie Nyssen
Fatigue has major implications on both patient safety and healthcare practitioner's well-being. Traditionally, two approaches can be used to reduce fatigue-related risk: reducing the likelihood of a fatigued operator working (i.e. fatigue reduction), or reducing the likelihood that a fatigued operator will make an error (i.e. fatigue proofing). Recent progress mainly focussed on fatigue reduction strategies such as reducing work hours. Yet it has to be recognized that such approach has not wholly overcome the experience of fatigue...
May 18, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29775836/cognitive-and-behavioural-dispositions-in-offspring-at-high-risk-for-alcoholism
#14
Rajesh Kumar, Keshav Janakiprasad Kumar, Vivek Benegal
OBJECTIVES: Offspring with family history of alcoholism are considered to be at high risk for alcoholism. The present study sought to expand our understanding of cognitive and behavioural dispositions associated with executive control and self-regulation in alcohol naïve offspring with and without family history of alcoholism. METHODS: Sample comprised of alcohol naive offspring in two groups: (i) at high risk (n = 34) and (ii) at low risk for alcoholism (n = 34)...
May 15, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29774435/neophobia-does-not-account-for-motoric-self-regulation-performance-as-measured-during-the-detour-reaching-cylinder-task
#15
M K Stow, A Vernouillet, D M Kelly
The ability to restrain a prepotent response in favor of a more adaptive behavior, or to exert inhibitory control, has been used as a measure of a species' cognitive abilities. Inhibitory control defines a spectrum of behaviors varying in complexity, ranging from self-control to motoric self-regulation. Several factors underlying inhibitory control have been identified, however, the influence of neophobia (i.e., aversion to novelty) on inhibitory control has not received much attention. Neophobia is known to affect complex cognitive abilities, but whether neophobia also influences more basic cognitive abilities, such as motoric self-regulation, has received less attention...
May 17, 2018: Animal Cognition
https://www.readbyqxmd.com/read/29771729/self-regulation-and-executive-functioning-as-related-to-survival-in-motor-neuron-disease-preliminary-findings
#16
Natasha E Garcia-Willingham, Abbey R Roach, Edward J Kasarskis, Suzanne C Segerstrom
OBJECTIVE: Disease progression varies widely among patients with motor neuron disease (MND). Patients with MND and coexisting dementia have shorter survival. However, implications of mild cognitive and behavioral difficulties are unclear. The present study examined the relative contribution of executive functioning and self-regulation difficulties on survival over a 6-year period among patients with MND, who scored largely within normal limits on cognitive and behavioral indices. METHODS: Patients with MND (N=37, age=59...
May 16, 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29771272/checking-behavior-fear-of-recurrence-and-daily-triggers-in-breast-cancer-survivors
#17
Emily C Soriano, Rosmeiry Valera, Elizabeth C Pasipanodya, Amy K Otto, Scott D Siegel, Jean-Philippe Laurenceau
Background: Fear of cancer recurrence (FCR) is a top ongoing concern of breast cancer (BC) survivors and thus the focus of recent intervention development. The Self-Regulation Model of FCR (Lee-Jones C, Humphris G, Dixon R, Hatcher MB. Fear of cancer recurrence-a literature review and proposed cognitive formulation to explain exacerbation of recurrence fears. Psychooncology. 1997;6:95-105.) states that everyday cancer-related events trigger FCR, which, in turn, leads to specific behavioral responses, including checking the body for signs or symptoms of cancer...
May 16, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29770461/psychometric-properties-and-factor-structure-of-the-adapted-self-regulation-questionnaire-assessing-autonomous-and-controlled-motivation-for-healthful-eating-among-youth-with-type-1-diabetes-and-their-parents
#18
V Quick, L M Lipsky, T R Nansel
BACKGROUND: The purpose of this cross-sectional study was to examine the psychometric properties of 2 adapted Self-Regulation Questionnaire (SRQ) measures assessing youth with type 1 diabetes motivation internalization for healthful eating and their parents motivation internalization for providing healthy meals for the family. METHODS: External validity of the adapted SRQ was evaluated with respect to healthy eating attitudes (healthful eating self-efficacy, barriers, and outcome expectations) assessed by questionnaire, diet quality (Healthy Eating Index-2005 [HEI-2005]; Nutrient-Rich Foods Index 9...
May 16, 2018: Child: Care, Health and Development
https://www.readbyqxmd.com/read/29769106/peer-mentor-versus-teacher-delivery-of-a-physical-activity-program-on-the-effects-of-bmi-and-daily-activity-protocol-of-a-school-based-group-randomized-controlled-trial-in-appalachia
#19
Laureen H Smith, Rick L Petosa, Abigail Shoben
BACKGROUND: Rural Appalachian populations have poorer health and fewer positive health-related behaviors compared to other United States populations. Appalachians are the most sedentary U.S. population and teens are particularly sedentary. Obesity prevention through improving physical activity is a top priority in Rural Healthy People 2020. Obesity prevalence among Appalachian teens exceeds the national rates of 13.9% and has consistently been greater than 26%. Organized sports has not been effective at improving daily physical activity or health outcomes for Appalachian teens...
May 16, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29768675/developing-self-regulation-in-a-dysregulating-world-attachment-and-biobehavioral-catch-up-for-a-toddler-in-foster-care
#20
Steven D Imrisek, Katerina Castaño, Kristin Bernard
Toddlers in foster care have typically experienced histories of maltreatment and disruptions in relationships with primary caregivers. As a result, they are at increased risk for developing disorganized attachment and showing emotional, behavioral, and physiological dysregulation. Attachment and Biobehavioral Catch-up for Toddlers in Foster Care (ABC-T) was developed to address the needs of these vulnerable children by supporting foster parents in responding with nurturance to children's distress, following children's lead, and helping children calm when they are becoming overwhelmed or dysregulated...
May 16, 2018: Journal of Clinical Psychology
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