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https://www.readbyqxmd.com/read/29145239/two-case-reports-colorectal-adenocarcinoma-in-children
#1
Chang Hoon Ahn, Soon Chul Kim
RATIONALE: Colorectal cancer in children is rare, with delayed diagnosis and advanced stage at presentation in high mortality. Early detection of colorectal cancer is, therefore, important for better prognosis. PATIENT CONCERNS: Thirteen-year-old boy presented with symptoms of melena, vomiting, and abdominal pain for 6 months. 18-year-old girl was hospitalized due to the symptoms of hematochezia, and persistent abdominal pain for 6 months. They have no chronic disease or familial history of malignancy...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143906/surgery-for-diverticular-disease-results-in-a-higher-hernia-rate-compared-to-colorectal-cancer-a-population-based-study-from-ontario-canada
#2
E S Tang, D I Robertson, M Whitehead, J Xu, S F Hall
BACKGROUND: Incisional hernias are a well described complication of abdominal surgery. Previous studies identified malignancy and diverticular disease as risk factors. We compared incisional hernia rates between colon resection for colorectal cancer (CRC) and diverticular disease (DD). STUDY DESIGN: We performed a retrospective, population-based, matched cohort study. Provincial databases were linked through the Institute for Clinical Evaluative Sciences. These databases include all patients registered under the universal Ontario Health Insurance Plan...
November 16, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29142183/worse-preoperative-status-based-on-inflammation-and-host-immunity-is-a-risk-factor-for-surgical-site-infections-in-colorectal-cancer-surgery
#3
Masano Sagawa, Kazuhiko Yoshimatsu, Hajime Yokomizo, Yuki Yano, Sachiyo Okayama, Takebumi Usui, Kentaro Yamaguchi, Shunichi Shiozawa, Takeshi Shimakawa, Takao Katsube, Hiroyuki Kato, Yoshihiko Naritaka
OBJECTIVE: The modified Glasgow Prognostic Score (mGPS) is an inflammation-based measure of malnutrition that reflects a state of cachexia in cancer patients. We evaluated mGPS as an index to predict surgical site infection (SSI) incidence in patients undergoing colorectal cancer surgery. SUBJECTS AND METHODS: We retrospectively analyzed 351 patients who underwent colon cancer resection. Factors correlated with the incidence of SSIs were identified by logistic analysis and stepwise selection...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29140558/adherence-to-treatment-guidelines-and-survival-for-older-patients-with-stage-ii-or-iii-colon-cancer-in-texas-from-2001-through-2011
#4
Hui Zhao, Ning Zhang, Vivian Ho, Minming Ding, Weiguo He, Jiangong Niu, Ming Yang, Xianglin L Du, Daria Zorzi, Mariana Chavez-MacGregor, Sharon H Giordano
BACKGROUND: Treatment guidelines for colon cancer recommend colectomy with lymphadenectomy of at least 12 lymph nodes for patients with stage I to stage III disease as surgery adherence (SA) and adjuvant chemotherapy for individuals with stage III disease. Herein, the authors evaluated adherence to these guidelines among older patients in Texas with colon cancer and the associated survival outcomes. METHODS: Using Texas Cancer Registry data linked with Medicare data, the authors included patients with AJCC stage II and III colon cancer who were aged ≥66 years and diagnosed between 2001 and 2011...
November 15, 2017: Cancer
https://www.readbyqxmd.com/read/29134384/totally-robotic-single-docking-low-anterior-resection-for-rectal-cancer-pearls-and-pitfalls
#5
J W T Toh, A Zakaria, I Yang, S H Kim
Total robotic resection of mid- and low rectal cancers confers technical advantages within the confines of the pelvis and allows difficult rectal cancer cases to be performed efficiently with less risk of conversion to open. To maximize the advantage of robotic surgery, we utilize the technique of single docking totally robotic dissection for rectal cancer for both the Da Vinci Si and Xi Surgical Systems. All steps are performed robotically, with the surgery divided into two phases. The first phase consists of inferior mesenteric artery and vein ligation, sigmoid and descending colon mobilization and splenic flexure takedown...
November 13, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29133757/soluble-triggering-receptor-expressed-on-myeloid-cells-1-and-inflammatory-markers-in-colorectal-cancer-surgery-a-prospective-cohort-study
#6
Lovorka Ðerek, Dražen Servis, Adriana Unić
BACKGROUND: Major abdominal surgery, including colorectal cancer (CRC) surgery, leads to systemic inflammatory response syndrome that can be detected and monitored with inflammatory markers testing. The aims of the study were to evaluate the usefulness of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) in following the inflammatory response in CRC surgery and postoperative period, as well as to determine if duration of the surgery and the time that the colon has been opened during the surgery (open colon time [OCT]) reflect a larger surgical stress through inflammatory markers rise...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29130230/-protective-measures-in-laparoscopic-resection-for-upper-or-mid-rectal-cancer-and-sigmoid-colon-cancer-with-transrectal-specimen-extraction-surgery
#7
Chuangang Fu, Zhuqing Zhou, Junyi Han, Bin Lu, Wei Gao, Zhe Zhu, Qixin Jiang, Fang Ji, Tao Du
OBJECTIVE: To introduce the use of a self-made specimen protective sleeve in laparoscopic resection for upper or mid rectal cancer and sigmoid colon cancer with transrectal specimen extraction surgery and the improvement of implantation method, so as to avoid and reduce bacterial contamination and tumor cell dissemination in abdominal cavity. METHODS: During June 2015 and May 2017, 48 cases of high located rectal or sigmoid colon cancer were operated laparoscopically with natural orifices specimen extraction surgery (NOSES) using a self-made specimen protecting sleeve...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29124012/necrotizing-soft-tissue-infection-of-the-thigh-associated-with-retroperitoneal-abscess-in-a-patient-with-locally-advanced-ascending-colon-cancer-a-case-report
#8
Shotaro Harada, Takaharu Kato, Shinichiro Okada, Kensuke Nakatani, Risa Matsumoto, Kazuhiro Nishida, Hiroyasu Komuro, Ai Yokoyama, Chikara Takase, Toshiyuki Suganuma
Necrotizing soft tissue infection (NSTI) is a rare but rapidly progressing soft-tissue infection. Few reports of NSTI caused by colon cancer have been published. We present a rare case of NSTI of the thigh associated the retroperitoneal spread of ascending colon cancer. A 64-year-old man had noticed right hip pain since 3 months before admission, he felt pain in the right thigh which was reddening, and he had difficulty in walking. He was referred to Yokosuka general hospital Uwamachi. Anterolateral aspect of his right thigh was reddening and swelling...
2017: IDCases
https://www.readbyqxmd.com/read/29121405/the-impact-of-visceral-adipose-tissue-amount-on-the-adequacy-of-lymph-node-retrieval-in-colorectal-cancer-surgery
#9
Eun Kyung Choe, Kyu Joo Park, Seung-Bum Ryoo, Sang Hui Moon, Heung-Kwon Oh, Eon Chul Han, Yoon-Hye Kwon
BACKGROUND: Obesity is increasing worldwide, potentially influencing surgical outcomes in colorectal cancer (CRC) patients. We analyzed the effects of obesity indexes on lymph node (LN) retrieval in CRC patients. METHOD: We applied obesity indexes of body mass index (BMI) and visceral (VAT) and subcutaneous (SAT) adipose tissue volumes to stage I-III CRC patients. The primary outcome was the effect of these indexes on the number of retrieved LNs (12 > LNs ≥ 12)...
November 9, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29119678/clinical-characteristics-of-ulcerative-colitis-related-colorectal-cancer-in-chinese-patients
#10
Ya Nan Wang, Ji Li, Wei Yang Zheng, Dong Wu, Hong Yang, Yue Li, Hong Lv, Bei Tan, Hui Jun Shu, Xi Yu Sun, Jia Ming Qian, Bin Wu, Jing Nan Li
OBJECTIVE: The prevalence of ulcerative colitis (UC) in China has increased in recent years, as has the incidence of ulcerative colitis related colorectal cancer (UCRCC). This study aimed to investigate the clinical features of UCRCC in Chinese UC patients. METHODS: Clinical data of patients with UCRCC was retrieved from the registration database of Peking Union Medical College Hospital during the period January 2003 to December 2016 and compared with that of sporadic CRC...
November 9, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29118565/is-complete-mesocolic-excision-oncologically-superior-to-conventional-surgery-for-colon-cancer-a-retrospective-comparative-study
#11
Christos Agalianos, Nikolaos Gouvas, Christos Dervenis, John Tsiaoussis, George Theodoropoulos, Demetrios Theodorou, George Zografos, Evaghelos Xynos
Background: During the last decade, many efforts have been made in order to improve the oncologic outcomes following colonic resection. Complete mesocolic excision (CME) has proved to provide high rates of disease-free and overall survival rates in patients undergoing resection for colonic malignancies. The aim of our study was to further investigate the role of CME in colonic surgery through comparison with a series of conventional resections. Methods: All data regarding resections for colonic cancer since 2006 were obtained prospectively from two surgical departments...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29113714/laparoscopic-versus-open-colectomy-for-obstructing-right-colon-cancer-a-systematic-review-and-meta-analysis
#12
R Cirocchi, F Cesare Campanile, S Di Saverio, G Popivanov, L Carlini, D Pironi, R Tabola, N Vettoretto
BACKGROUND: Hemicolectomy is the treatment of choice for intestinal obstruction from right colon cancer. This review compares the laparoscopic vs open access in hemicolectomy for patients with right colon cancer. METHODS: A systematic review and meta-analysis of clinical studies published after January 2017 was performed according to the Prisma guidelines. The study has been recorded on the Prospero register (CRD42016044108). RESULTS: Five studies were included for review...
November 4, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29113675/surgery-induced-tumor-growth-in-metastatic-colorectal-cancer
#13
REVIEW
Klaas M Govaert, Jennifer M J Jongen, Onno Kranenburg, Inne H M Borel Rinkes
Metastatic colorectal cancer (mCRC) is a devastating disease causing 700.000 deaths annually worldwide. Metastases most frequently develop in the liver. Partial hepatectomy has dramatically improved clinical outcome and is the only curative treatment option for eligible patients with mCRC. Pre-clinical studies have shown that surgical procedures can have tumor-promoting local 'side-effects' such as hypoxia and inflammation, thereby altering the behaviour of residual tumor cells. In addition, systemically released factors following (colon or liver) surgery can act as a wakeup-call for dormant tumor cells in distant organs and/or help establish a pre-metastatic niche...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29112559/do-moderate-surgical-treatment-delays-influence-survival-in-colon-cancer
#14
Kerollos Nashat Wanis, Sanjay V B Patel, Muriel Brackstone
BACKGROUND: Studies examining treatment delay and survival after surgical treatment of colon cancer have varied in quality and outcome, with little evidence available regarding the safety of longer surgical treatment wait times. OBJECTIVE: Our study examined the effect of surgical treatment wait times on survival for patients with stage I to III colon cancer. DESIGN: A subset cohort analysis was performed using data from a prospectively maintained database...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29108388/the-impact-of-delayed-commencement-of-adjuvant-chemotherapy-eight-or-more-weeks-on-survival-in-stage-ii-and-iii-colon-cancer-a-national-population-based-cohort-study
#15
Young Wan Kim, Eun Hee Choi, Bo Ra Kim, Woo-Ah Ko, Yeong-Mee Do, Ik Yong Kim
Background: To examine the impact of chemotherapy delay on survival in patients with stage II or III colon cancer and the factors associated with the delay (≥8 weeks) of adjuvant chemotherapy. Methods: Patients undergoing curative resection and adjuvant chemotherapy in a national population-based cohort were included. Results: Among 5355 patients, 154 (2.9%) received chemotherapy more than 8 weeks after surgery. Based on a multivariate analysis, the risk factors associated with chemotherapy delay ≥8 weeks were older age [65 to 74 years (hazard ratio [HR]=1...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29105290/endoscopic-resection-of-large-colorectal-adenomas-clinical-experience-of-a-tertiary-referral-center
#16
Liat Mlynarsky, Shira Zelber-Sagi, Eliaz Miller, Revital Kariv
BACKGROUND: Colorectal cancer is a leading cause for cancer-related mortality. Adenomatous polyps are typically resected endoscopically to prevent cancer while giant and complex polyps are managed surgically. No criteria clearly define the indications for surgical versus endoscopic resection. AIM: To evaluate factors associated with short-term efficacy and safety of endoscopic resection of large (≥20mm) and giant (≥40mm) adenomas. METHODS: Consecutive cases with colonic adenomas larger than 20mm, resected endoscopically were included...
November 4, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29099643/significant-expression-of-taz-protein-in-colon-cancer-cells-and-it-s-downregulation-by-radiation
#17
Surajit Pathak, Antara Banerjee, Wen-Jian Meng, Suman Kumar Nandy, Madhumala Gopinath, Xiao-Feng Sun
AIM: To demonstrate the radiation responses of TAZ in colon cancer. METHODS: TAZ expression was examined in colon cancer cell lines SW480, KM12C, SW620 and KM12L4a. We used KM12C and KM12L4a for the experiment by using X-rays and UV rays (mW/cm(2)). We used HCT15 cell line to test the expression of TAZ by using an anti-TAZ drug, viz., 9-fluorenone, which is a hippo-yap/taz signaling inhibitor. The experimentation also involved exposing HCT15 cell line, to radiation...
November 3, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29098076/intraluminal-ileal-tumour-after-right-hemicolectomy-for-cancer-an-implantation-recurrence-or-a-new-cancer-a-case-report
#18
Marco Clementi, Sara Colozzi, Mario Schietroma, Federico Sista, Andrea Della Penna, Alessandro Chiominto, Stefano Guadagni
Introduction: Extra-anastomotic intraluminal recurrence of the colon cancer after curative surgery was rarely reported but intraluminal ileal relapse has not been described to date.We report a case of intraluminal ileal tumor arising after curative right hemicolectomy that could be ascribed to an implantation of exfoliated cancer cells. Case report: A 71-years old man was admitted with no metastatic stenotic adenocarcinoma of the hepatic flexure and submitted, without preoperative bowel preparation, to right hemicolectomy using a "no-touch" technique...
November 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29097072/recommendations-for-randomised-trials-in-surgical-oncology
#19
J C Glasbey, E L Magill, K Brock, S P Bach
Trials of surgical procedures in the treatment of malignant disease face a unique set of challenges. This review aimed to describe recommendations for the design, delivery and reporting of randomised trials in surgical oncology. A literature search was carried out without date limits to identify articles related to trial methodology research in surgery and surgical oncology. A narrative review was framed around two open National Institute of Health Research portfolio trials in colon and rectal cancer: the STAR-TREC trial (ISRCTN14240288) and the ROCCS trial (ISRCTN46330337)...
October 30, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29091337/complete-mesocolic-excision-cme-in-right-sided-colon-cancer-does-not-increase-severe-short-term-postoperative-adverse-events
#20
Richard Bernhoff, Annika Sjövall, Christian Buchli, Fredrik Granath, Torbjörn Hol, Anna Martling
OBJECTIVE: To assess whether Complete Mesocolic Excision (CME) in patients with right sided colon cancer is related to short term mortality or postoperative adverse events requiring reoperation. BACKGROUND: The complete mobilization of an integral mesocolon and central ligation of blood vessels are essential steps in CME-surgery. The resultant specimen, with an intact mesocolic fascia and a high number of harvested lymph nodes is believed to be oncologically favourable...
November 1, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
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