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https://www.readbyqxmd.com/read/29780794/pediatric-scurvy-when-contemporary-eating-habits-bring-back-the-past
#1
Alice Brambilla, Cristina Pizza, Donatella Lasagni, Lucia Lachina, Massimo Resti, Sandra Trapani
Vitamin C deficiency is anecdotal in developed countries, mainly associated with underling clinical morbidities as autism or neurological impairment. Chronic insufficient dietary supply is responsible for vascular fragility and impaired bone formation, resulting in gingival bleeding, petechial lesions, articular and bone pain or limb swelling. Children may present anorexia, irritability, failure to thrive, limping or refusal to walk. Accordingly, pediatric scurvy is frequently misdiagnosed with osteomyelitis, septic arthritis, bone and soft tissue tumor, leukemia, bleeding disorders, and rheumatologic conditions...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29770995/adolescent-and-young-adult-oncology-patients-in-france-heterogeneity-in-pathways-of-care
#2
Emmanuel Desandes, Laurence Brugières, Florence Molinié, Gautier Defossez, Patricia Delafosse, Karine Jehannin-Ligier, Michel Velten, Brigitte Trétarre, Brice Amadéo, Emilie Marrer, Anne-Sophie Woronoff, Olivier Ganry, Alain Monnereau, Tania d'Almeida, Xavier Troussard, Laetitia Daubisse-Marliac, Simona Bara, Anne-Valérie Guizard, Isabelle Baldi, Guy Launoy, Jacqueline Clavel, Brigitte Lacour
BACKGROUND: In order to evaluate at the population level the impact of the actions developed in France since 2004 to organize the care of adolescents and young adults (AYAs) with cancer, we conducted the present study to provide an unbiased view of the pathway of care of these patients. METHODS: Using a population-based registry, we conducted a review of all cases of cancer diagnosed during 2012 and 2013 in 15- to 24-year-old patients living in nineteen French administrative areas...
May 17, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29765083/adeno-associated-virus-vector-mediated-interleukin-10-induction-prevents-vascular-inflammation-in-a-murine-model-of-kawasaki-disease
#3
Jun Nakamura, Sachiko Watanabe, Hiroaki Kimura, Motoi Kobayashi, Tadayoshi Karasawa, Ryo Kamata, Fumitake Usui-Kawanishi, Ai Sadatomo, Hiroaki Mizukami, Noriko Nagi-Miura, Naohito Ohno, Tadashi Kasahara, Seiji Minota, Masafumi Takahashi
Kawasaki disease (KD), which is the leading cause of pediatric heart disease, is characterized by coronary vasculitis and subsequent aneurysm formation. Although intravenous immunoglobulin therapy is effective for reducing aneurysm formation, a certain number of patients are resistant to this therapy. Because interleukin-10 (IL-10) was identified as a negative regulator of cardiac inflammation in a murine model of KD induced by Candida albicans water-soluble fraction (CAWS), we investigated the effect of IL-10 supplementation in CAWS-induced vasculitis...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29764855/magnetic-resonance-imaging-of-tumor-associated-macrophages-clinical-translation
#4
Maryam Aghighi, Ashok Joseph Theruvath, Anuj Pareek, Laura Pisani, Raphael Alford, Anne Monika Muehe, Tarsheen K Sethi, Samantha J Holdsworth, Florette K Hazard, Dita Gratzinger, Sandra Luna-Fineman, Ranjana H Advani, Sheri L Spunt, Heike E Daldrup-Link
PURPOSE: Tumor associated macrophages (TAM) in malignant tumors have been linked to tumor aggressiveness and represent a new target for cancer immunotherapy. As new TAM-targeted immunotherapies are entering clinical trials, it is important to detect and quantify TAM with non-invasive imaging techniques. The purpose of this study was to determine if ferumoxytol-enhanced MRI can detect TAM in lymphomas and bone sarcomas of pediatric patients and young adults. EXPERIMENTAL DESIGN: In a first-in-patient , IRB-approved prospective clinical trial, 25 pediatric and young adult patients with lymphoma or bone sarcoma underwent ferumoxytol-enhanced MRI...
May 15, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29750745/successful-treatment-of-osteosarcoma-without-methotrexate-in-a-13-year-old-boy-with-down-syndrome
#5
Emma Sims, Audrey Nath, Aaron Sugalski
Osteosarcoma is the most common primary bone tumor in children, and only 1 article in the literature describes a case of osteosarcoma in a patient with Down syndrome. Although osteosarcoma is generally treated with chemotherapy regimens that include high-dose methotrexate, patients with Down syndrome have heightened sensitivity to the toxicities of methotrexate. The patient from the aforementioned case study died from sepsis soon after treatment with high-dose methotrexate. This case report describes the successful treatment of osteosarcoma in a pediatric patient with Down syndrome without methotrexate...
May 10, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29732366/importance-of-comprehensive-molecular-profiling-for-clinical-outcome-in-children-with-recurrent-cancer
#6
Olga Østrup, Karsten Nysom, David Scheie, Ane Y Schmidt, Rene Mathiasen, Lisa L Hjalgrim, Tina E Olsen, Jane Skjøth-Rasmussen, Birthe M Henriksen, Finn C Nielsen, Peder S Wehner, Henrik Schrøder, Astrid M Sehested, Catherine Rechnitzer, Maria Rossing
Purpose: Pediatric cancers are often difficult to classify and can be complex to treat. To ensure precise diagnostics and identify relevant treatment targets, we implemented comprehensive molecular profiling of consecutive pediatric patients with cancer relapse. We evaluated the clinical impact of extensive molecular profiling by assessing the frequency of identified biological onco-drivers, altered diagnosis, and/or identification of new relevant targeted therapies. Patients and Methods: Forty-six tumor samples (44 fresh-frozen; two formalin-fixed paraffin embedded), two bone marrow aspirates, three cerebrospinal fluid samples, and one archived DNA were obtained from 48 children (0-17 years; median 9...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29718224/the-association-of-diet-and-exercise-with-body-composition-in-pediatric-crohn-s-disease
#7
Dale Lee, James D Lewis, Justine Shults, Robert N Baldassano, Jin Long, Rita Herskovitz, Babette Zemel, Mary B Leonard
Background: In pediatric Crohn's disease, fat mass improves over time with treatment, but lean mass deficits persist. This observational study of the associations of physical activity and dietary intake with lean mass and muscle strength in children with Crohn's disease was ancillary to a previously reported randomized clinical trial of an intervention to improve bone health. Methods: In this study, 138 participants were followed at baseline and at 6, 12, and 24 months with evaluation of lean and fat mass using DXA, muscle strength (peak torque), Crohn's characteristics, dietary intake, time in moderate to vigorous physical activity (MVPA), and serum insulin-like growth factor-1 (IGF-1) and tumor necrosis factor-alpha (TNF-α)...
April 27, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29703037/fatal-malignant-pertussis-with-hyperleukocytosis-in-a-chinese-infant-a-case-report-and-literature-review
#8
Shu-Feng Tian, Hong-Mei Wang, Ji-Kui Deng
RATIONALE: Pertussis has re-emerged on a global scale and is an ongoing public health problem, even in countries with high rates of vaccination. Hyperleukocytosis [white blood cell (WBC) count >100 × 10/L] is a rare complication that strongly predicts mortality in cases of severe pertussis. PATIENT CONCERNS: We report a case of severe pertussis in an infant who initially presented with persistent cyanotic cough, tachypnea, and grunting. The infant's condition deteriorated rapidly, and she was transferred to the pediatric intensive care unit (PICU) during her third hour of hospitalization...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29689253/histone-h3-3-g34-mutations-alter-histone-h3k36-and-h3k27-methylation-in-cis
#9
Leilei Shi, Jiejun Shi, Xiaobing Shi, Wei Li, Hong Wen
Histone H3 encoding genes, particularly H3F3A and H3F3B, the genes encoding the variant histone H3.3, are mutated at high frequency in pediatric brain and bone malignancies. Compared to the extensive stidues on K27M and K36M mutations, little is known about the mechanism of G34 mutations found in pediatric glioblastoma (GBM) or giant cell tumors of the bone (GCTB). Here we report that unlike the K27M or K36M that affect global histone methylation, the GCBT G34 mutations (G34L/W) only affect histone H3K36 and H3K27 methylation on the same mutated histone tails (in cis), a mechanism distinct from known histone mutations...
April 21, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29681425/epidemiology-and-national-trends-in-prevalence-and-surgical-management-of-metastatic-spinal-disease
#10
Samantha R Horn, Ekamjeet S Dhillon, Gregory W Poorman, Jared C Tishelman, Frank A Segreto, Cole A Bortz, John Y Moon, Omar Behery, Nicholas Shepard, Bassel G Diebo, Shaleen Vira, Peter G Passias
Surgical treatment for spinal metastasis has benefited from improvements in surgical techniques. However, the trends in treatment and outcomes for spinal metastasis surgery have not been well-established in a pediatric population. Patients <20 years old with metastatic spinal tumors undergoing spinal surgery were identified in the KID database. Trends for spinal metastases treatment and patient outcomes were analyzed using weight-adjusted ANOVAs. 333 patients were identified in the KID database. The top five primary diagnoses were metastatic brain/spinal cord tumor (19...
April 19, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29667143/diagnostic-performance-of-18-f-fdg-pet-ct-and-whole-body-diffusion-weighted-imaging-with-background-body-suppression-dwibs-in-detection-of-lymph-node-and-bone-metastases-from-pediatric-neuroblastoma
#11
Hiroaki Ishiguchi, Shinji Ito, Katsuhiko Kato, Yusuke Sakurai, Hisashi Kawai, Naotoshi Fujita, Shinji Abe, Atsushi Narita, Nobuhiro Nishio, Hideki Muramatsu, Yoshiyuki Takahashi, Shinji Naganawa
OBJECTIVE: Recent many studies have shown that whole body "diffusion-weighted imaging with background body signal suppression" (DWIBS) seems a beneficial tool having higher tumor detection sensitivity without ionizing radiation exposure for pediatric tumors. In this study, we evaluated the diagnostic performance of whole body DWIBS and 18 F-FDG PET/CT for detecting lymph node and bone metastases in pediatric patients with neuroblastoma. METHODS: Subjects in this retrospective study comprised 13 consecutive pediatric patients with neuroblastoma (7 males, 6 females; mean age, 2...
April 17, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29650946/a-rare-case-of-relapsed-pediatric-acute-promyelocytic-leukemia-with-skin-involvement-by-myeloid-sarcoma
#12
Nathalia Silva Araújo, Claudio José Dos Santos Júnior, Vitória Mikaelly da Silva Gomes, Luiz Arthur Calheiros Leite, Luana Novaes Bomfim, Amanda Katielly Firmino da Silva Gusmão, Maria Jordana Rocha Gomes Alves, Cyndi Myrelle da Silva Barros Romão, Arthur Moacir Costa Sampaio Batinga, Maria Rosa da Silva, Célio Fernando de Sousa Rodrigues
BACKGROUND Acute promyelocytic leukemia (APL) is a very rare leukemia in children. Extramedullary involvement by APL has been reported in between 3-5% of cases, mainly associated with cases of relapse. A rare case of relapse of APL in a 9-year-old child is presented with skin involvement with myeloid sarcoma. CASE REPORT A 9-year-old male child was admitted to the Oncology Service of the hospital complaining of fever, progressive fatigue, oral petechiae with severe bleeding in the oral cavity. Bone marrow examination showed some promyelocytes...
April 13, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29627863/the-codesign-of-an-interdisciplinary-team-based-intervention-regarding-initiating-palliative-care-in-pediatric-oncology
#13
Douglas L Hill, Jennifer K Walter, Jessica A Casas, Concetta DiDomenico, Julia E Szymczak, Chris Feudtner
PURPOSE: Children with advanced cancer are often not referred to palliative or hospice care before they die or are only referred close to the child's death. The goals of the current project were to learn about pediatric oncology team members' perspectives on palliative care, to collaborate with team members to modify and tailor three separate interdisciplinary team-based interventions regarding initiating palliative care, and to assess the feasibility of this collaborative approach. METHODS: We used a modified version of experience-based codesign (EBCD) involving members of the pediatric palliative care team and three interdisciplinary pediatric oncology teams (Bone Marrow Transplant, Neuro-Oncology, and Solid Tumor) to review and tailor materials for three team-based interventions...
April 7, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29610692/successful-complete-response-of-tumor-thrombus-after-combined-with-chemotherapy-and-irradiation-for-ewing-sarcoma
#14
Yusuke Minami, Seiichi Matsumoto, Keisuke Ae, Taisuke Tanizawa, Keiko Hayakawa, Yuki Funauchi, Sakae Okumura, Yutaka Takazawa
Pelvic Ewing sarcoma is associated with a worse prognosis. Thromboembolic events are relatively common in pediatric patients with cancers including sarcomas. We have presented a case of Ewing sarcoma arising from the left iliac bone with tumor thrombus of inferior vena cava (IVC) which was obtained complete response by both chemotherapy and irradiation. Magnetic resonance imaging (MRI) scan demonstrated that the tumor arising from the left iliac bone extended into the left side of sacral bone, suggesting the difficulty of surgical resection...
2018: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29608111/profile-of-non-hematological-pediatric-tumors-a-clinicopathological-study-at-a-tertiary-health-care-centre
#15
Kashmi Sharma, Mehar Aziz, Nishat Afroz, Aaliya Ehsan
BACKGROUND: Tumors in pediatric age group are biologically different from tumors in adults and emerging as a significant contributor to morbidity/mortality in children. OBJECTIVES: This study evaluated the epidemiological profile of pediatric solid tumors in 0-18 years of age over a period of 5 years in a general hospital in India. RESULTS: A total of 510 cases of tumors were included, which accounted for 5.1% of the total tumor burden of the hospital...
April 2, 2018: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/29588889/orbitopterional-craniotomy-resection-of-pediatric-suprasellar-craniopharyngioma
#16
Devon LeFever, Chris Storey, Bharat Guthikonda
The orbitopterional approach provides an excellent combination of basal access and suprasellar access. This approach also allows for less brain retraction when resecting larger suprasellar tumors that are more superiorly projecting due to a more frontal and inferior trajectory. In this operative video, the authors thoroughly detail an orbitopterional craniotomy utilizing a one-piece modified orbitozygomatic technique. This technique involves opening the craniotomy through a standard pterional incision. The craniotomy is performed using the standard three burr holes of a pterional approach; however, the osteotomy is extended anteriorly through the frontal process of the zygomatic bone as well as through the supraorbital rim...
April 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29581854/ire1%C3%AE-xbp1-inhibitors-exerted-anti-tumor-activities-in-ewing-s-sarcoma
#17
Yu Tanabe, Yoshiyuki Suehara, Shinji Kohsaka, Takuo Hayashi, Keisuke Akaike, Kenta Mukaihara, Taisei Kurihara, Youngji Kim, Taketo Okubo, Midori Ishii, Saiko Kazuno, Kazuo Kaneko, Tsuyoshi Saito
Ewing's sarcoma (ES) is the second-most frequent pediatric bone tumor. Chromosomal translocation t(11;22)(q24:q12) results in the formation of EWS/FLI1 gene fusion, which is detected in approximately 90% of tumors of the Ewing family. Several transcriptome studies have provided lists of genes associated with EWS/FLI1 expression. However, the protein expression profiles associated with EWS/FLI1 have yet to be elucidated. In this study, to identify the regulated proteins associated with EWS/FLI1 and therapeutic targets in ES, we conducted proteomic studies using EWS/FLI1 knockdown in four Ewing's sarcoma cell lines and human mesenchymal stem cells (hMSCs) expressing EWS/FLI1...
March 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29549514/bone-loss-and-hematological-malignancies-in-adults-a-pilot-study
#18
Rosa Ruchlemer, Michal Amit-Kohn, Ariella Tvito, Irena Sindelovsky, Ari Zimran, David Raveh-Brawer
PURPOSE: Bone loss-osteopenia and osteoporosis-is a recognized consequence of solid tumors in adults, of pediatric hematological malignancies, and of the treatment for these diseases, but little research has been published on the adverse effects of hematological malignancies on the bone in adults. The aim of this study is to identify hematological diseases that are associated with the highest prevalence and severity of osteoporosis. METHODS: We evaluated DXA (dual-energy X-ray absorptiometry) in a cross-section of 181 adult patients with hematological neoplasms, excluding multiple myeloma...
March 16, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29543677/fluorescent-in-situ-hybridization-for-tp53-in-the-diagnosis-of-pediatric-osteogenic-sarcoma
#19
Paula Marrano, Mary Shago, Gino R Somers, Paul S Thorner
Osteogenic sarcoma (OS) is the most common malignant bone tumor in children and adolescents. Despite advances in molecular genetic characterization of pediatric and adult tumors, the diagnosis of OS still depends almost entirely on light microscopy. The lack of consistent genetic changes in OS has greatly hindered the development of any diagnostic molecular test. Recently, whole-genome sequencing has shown that ~50% of cases of OS have a translocation involving the TP53 gene with breakpoints confined to the first intron...
June 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29529641/mri-identification-of-the-osseous-extent-of-pediatric-bone-sarcomas
#20
Matthew J Thompson, John C Shapton, Stephanie E Punt, Christopher N Johnson, Ernest U Conrad
BACKGROUND: The quantitative accuracy of MRI in predicting the intraosseous extent of primary sarcoma of bone has not been definitively confirmed, although MRI is widely accepted as an accurate tool to plan limb salvage resections. Because inaccuracies in MRI determination of tumor extent could affect the ability of a tumor surgeon to achieve negative margins and avoid local recurrence, we thought it important to assess the accuracy of MR-determined tumor extent to the actual extent observed pathologically from resected specimens in pediatric patients treated for primary sarcomas of bone...
March 2018: Clinical Orthopaedics and related Research
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