E V Shchegol'kov, I V Shchur, Ya V Burgart, V I Saloutin, A N Trefilova, G A Ljushina, S Yu Solodnikov, L N Markova, V V Maslova, O P Krasnykh, S S Borisevich, S L Khursan
We have developed the convenient methods for synthesis of polyfluorosalicylic acids and their derivatives. For the first time the biological properties of polyfluorosalicylates were investigated in vitro (permeability through the biological membranes, COX-1 inhibitory action) and in vivo (anti-inflammatory, analgesic activities, acute toxicity). Molecular docking of polyfluorinated salicylates confirmed in vitro and in vivo experiments.
October 12, 2016: Bioorganic & Medicinal Chemistry