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https://www.readbyqxmd.com/read/28538795/neonatal-near-miss-and-mortality-factors-associated-with-life-threatening-conditions-in-newborns-at-six-public-maternity-hospitals-in-southeast-brazil
#1
Pauline Lorena Kale, Maria Helena Prado de Mello-Jorge, Kátia Silveira da Silva, Sandra Costa Fonseca
We aimed to evaluate factors associated with cases of neonatal near miss and neonatal deaths at six public maternity hospitals in São Paulo and Rio de Janeiro States, Brazil, in 2011. A prospective hospital-based birth cohort investigated these outcomes among live births with life-threatening conditions. Associations were tested using multinomial logistic regression models with hierarchical levels. High rates of near miss were observed for maternal syphilis (52.2‰ live births) and lack of prenatal care (80...
May 18, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28538739/multiplex-pcr-method-for-minion-and-illumina-sequencing-of-zika-and-other-virus-genomes-directly-from-clinical-samples
#2
Joshua Quick, Nathan D Grubaugh, Steven T Pullan, Ingra M Claro, Andrew D Smith, Karthik Gangavarapu, Glenn Oliveira, Refugio Robles-Sikisaka, Thomas F Rogers, Nathan A Beutler, Dennis R Burton, Lia Laura Lewis-Ximenez, Jaqueline Goes de Jesus, Marta Giovanetti, Sarah C Hill, Allison Black, Trevor Bedford, Miles W Carroll, Marcio Nunes, Luiz Carlos Alcantara, Ester C Sabino, Sally A Baylis, Nuno R Faria, Matthew Loose, Jared T Simpson, Oliver G Pybus, Kristian G Andersen, Nicholas J Loman
Genome sequencing has become a powerful tool for studying emerging infectious diseases; however, genome sequencing directly from clinical samples (i.e., without isolation and culture) remains challenging for viruses such as Zika, for which metagenomic sequencing methods may generate insufficient numbers of viral reads. Here we present a protocol for generating coding-sequence-complete genomes, comprising an online primer design tool, a novel multiplex PCR enrichment protocol, optimized library preparation methods for the portable MinION sequencer (Oxford Nanopore Technologies) and the Illumina range of instruments, and a bioinformatics pipeline for generating consensus sequences...
June 2017: Nature Protocols
https://www.readbyqxmd.com/read/28538727/establishment-and-cryptic-transmission-of-zika-virus-in-brazil-and-the-americas
#3
N R Faria, J Quick, I M Claro, J Thézé, J G de Jesus, M Giovanetti, M U G Kraemer, S C Hill, A Black, A C da Costa, L C Franco, S P Silva, C-H Wu, J Raghwani, S Cauchemez, L du Plessis, M P Verotti, W K de Oliveira, E H Carmo, G E Coelho, A C F S Santelli, L C Vinhal, C M Henriques, J T Simpson, M Loose, K G Andersen, N D Grubaugh, S Somasekar, C Y Chiu, J E Muñoz-Medina, C R Gonzalez-Bonilla, C F Arias, L L Lewis-Ximenez, S A Baylis, A O Chieppe, S F Aguiar, C A Fernandes, P S Lemos, B L S Nascimento, H A O Monteiro, I C Siqueira, M G de Queiroz, T R de Souza, J F Bezerra, M R Lemos, G F Pereira, D Loudal, L C Moura, R Dhalia, R F França, T Magalhães, E T Marques, T Jaenisch, G L Wallau, M C de Lima, V Nascimento, E M de Cerqueira, M M de Lima, D L Mascarenhas, J P Moura Neto, A S Levin, T R Tozetto-Mendoza, S N Fonseca, M C Mendes-Correa, F P Milagres, A Segurado, E C Holmes, A Rambaut, T Bedford, M R T Nunes, E C Sabino, L C J Alcantara, N J Loman, O G Pybus
Transmission of Zika virus (ZIKV) in the Americas was first confirmed in May 2015 in northeast Brazil. Brazil has had the highest number of reported ZIKV cases worldwide (more than 200,000 by 24 December 2016) and the most cases associated with microcephaly and other birth defects (2,366 confirmed by 31 December 2016). Since the initial detection of ZIKV in Brazil, more than 45 countries in the Americas have reported local ZIKV transmission, with 24 of these reporting severe ZIKV-associated disease. However, the origin and epidemic history of ZIKV in Brazil and the Americas remain poorly understood, despite the value of this information for interpreting observed trends in reported microcephaly...
May 24, 2017: Nature
https://www.readbyqxmd.com/read/28538623/impact-of-a-novel-pi3-kinase-inhibitor-in-preventing-mitochondrial-dna-damage-and-damage-associated-molecular-pattern-accumulation-results-from-the-biochronicity-project
#4
George E Black, Kyle K Sokol, Donald M Moe, Jon Simmons, David Muscat, Victor Pastukh, Gina Capley, Olena Gorodnya, Mykhalo Ruchko, Mark B Roth, Mark Gillespie, Matthew J Martin
BACKGROUND: Despite improvements in the management of severely injured patients, development of multiple organ dysfunction syndrome (MODS) remains a morbid complication of traumatic shock. One of the key attributes of MODS is a profound bioenergetics crisis, for which the mediators and mechanisms are poorly understood. We hypothesized that metabolic uncoupling using an experimental PI3-kinase inhibitor, LY294002 (LY), may prevent mitochondrial abnormalities that lead to the generation of mitochondrial DNA (mtDNA) damage and the release of mtDNA damage associated molecular patterns (DAMPs) METHODS: 16 swine were studied using LY294002 (LY), a non-selective PI3-KI: Animals were assigned to Trauma only (TO, N=3); LY drug only (LYO, N=3); and Experimental (N=10), trauma + drug (LY+T) groups...
May 22, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28538508/central-nervous-system-disease-education-and-race-impact-radiation-refusal-in-pediatric-cancer-patients
#5
Chirayu G Patel, Mark Stavas, Stephanie Perkins, Eric T Shinohara
To investigate the determinants of radiation therapy refusal in pediatric cancer, we used the Surveillance, Epidemiology, and End Results registry to identify 24,421 patients who met the eligibility criteria, diagnosed between 1974 and 2012. Patients had any stage of cancer, were aged 0 to 19, and received radiation therapy or refused radiation therapy when it was recommended. One hundred twenty-eight patients (0.52%) refused radiation therapy when it was recommended. Thirty-two percent of patients who refused radiation therapy ultimately died from their cancer, at a median of 7 months after diagnosis (95% confidence interval, 3-11 mo), as compared with 29...
May 22, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28538274/prevalence-of-pulmonary-embolism-among-systemic-lupus-erythematosus-discharges-a-decade-of-analysis-of-the-national-hospital-discharge-survey
#6
Srinadh Annangi, Tirumala Rao Dammalapati, Snigdha Nutalapati, Marshaleen N Henriques King
INTRODUCTION: Pulmonary embolism (PE) is a life threatening preventable medical condition involving sudden occlusion of arteries within the lungs. Systemic lupus erythematosus (SLE) is an inflammatory disorder and therefore independently poses a risk of PE. We aimed to determine the association of SLE and PE using National Hospital Discharge Survey data, a national representative sample of hospital discharges throughout the United States. METHODS: Retrospective population-based analysis was done using National Hospital Discharge Survey data for the period 2001 to 2010...
June 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28538169/racial-differences-in-colorectal-cancer-survival-at-a-safety-net-hospital
#7
Umit Tapan, Shin Yin Lee, Janice Weinberg, Vijaya B Kolachalama, Jean Francis, Marjory Charlot, Kevan Hartshorn, Vipul Chitalia
BACKGROUND: While racial disparity in colorectal cancer survival have previously been studied, whether this disparity exists in patients with metastatic colorectal cancer receiving care at safety net hospitals (and therefore of similar socioeconomic status) is poorly understood. METHODS: We examined racial differences in survival in a cohort of patients with stage IV colorectal cancer treated at the largest safety net hospital in the New England region, which serves a population with a majority (65%) of non-Caucasian patients...
May 21, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28538043/building-healthy-development-and-behavior-among-wic-participants
#8
Maureen M Black, Bridget Armstrong
No abstract text is available yet for this article.
May 18, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28537988/prevention-of-trastuzumab-and-anthracycline-induced-cardiotoxicity-using-angiotensin-converting-enzyme-inhibitors-or-%C3%AE-blockers-in-older-adults-with-breast-cancer
#9
Saranrat Wittayanukorn, Jingjing Qian, Salisa C Westrick, Nedret Billor, Brandon Johnson, Richard A Hansen
PURPOSE: Although clinical trials have provided some data on the benefit of angiotensin-converting enzyme inhibitors (ACEIs) or β-blockers (BBs) in patients with chemotherapy-induced cardiotoxicity, evidence of ACEIs/BBs on prevention of trastuzumab and/or anthracycline-induced cardiotoxicity outside trials is limited. MATERIALS AND METHODS: A cohort study of 142,990 women (66 y and above) newly diagnosed with breast cancer from 2001 to 2009 was conducted using the Surveillance, Epidemiology, and End Results-Medicare-linked database...
May 23, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28537948/current-techniques-and-outcomes-in-hysteroscopic-sterilization-current-evidence-considerations-and-complications-with-hysteroscopic-sterilization-micro-inserts
#10
James Casey, Laura Cedo-Cintron, Jessica Pearce, Amanda Yunker
PURPOSE OF REVIEW: To describe the current data regarding effectiveness, complications, postoperative evaluation, and surgical interventions associated with Essure hysteroscopic sterilization. RECENT FINDINGS: Hysteroscopic sterilization is a commonly performed procedure that is offered as a well tolerated, effective, outpatient method of permanent sterilization. Over the past several years, concerns have been raised regarding correct placement and postoperative complications...
May 19, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28537845/high-rates-of-access-to-health-care-disclosure-of-sexuality-and-gender-identity-to-providers-among-house-and-ball-community-members-in-new-york-city
#11
Sean Cahill, Sarah Trieweiler, John Guidry, Nelisa Rash, Layla Stamper, Kerith Conron, Nicole Turcotte, Ilana Gratch, Paige Lowry
The House and Ball community is an important cultural manifestation of resiliency for Black and Latino gay and bisexual men and transgender women. Participants at the August, 2013 House of Latex Ball in New York City were surveyed about insurance coverage, health care access, experiences in health care, and housing instability. The sample (n = 367) was 58% Black/African American and 20% Hispanic/Latino, with a mean age of 31. Fifty-five percent were gay and bisexual men. While only 6% identified as transgender, nearly half were gender nonconforming...
May 24, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28537812/perspectives-of-patients-with-cancer-on-the-ethics-of-rapid-learning-health-systems
#12
Reshma Jagsi, Kent A Griffith, Aaron Sabolch, Rochelle Jones, Rebecca Spence, Raymond De Vries, David Grande, Angela R Bradbury
Purpose To inform the evolving implementation of CancerLinQ and other rapid-learning systems for oncology care, we sought to evaluate perspectives of patients with cancer regarding ethical issues. Methods Using the GfK Group online research panel, representative of the US population, we surveyed 875 patients with cancer; 621 (71%) responded. We evaluated perceptions of appropriateness (scored from 1 to 10; 10, very appropriate) using scenarios and compared responses by age, race, and education. We constructed a scaled measure of comfort with secondary use of deidentified medical information and evaluated its correlates in a multivariable model...
May 24, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28535617/epidemiology-and-clinical-characteristics-of-sarcoidosis-an-update-from-a-population-based-cohort-study-from-olmsted-county-minnesota
#13
P Ungprasert, C S Crowson, E L Matteson
Information about the epidemiology, clinical manifestations and comorbidities of sarcoidosis among Caucasians is relatively scarce. This review focuses primarily on the data from a recently published Caucasianpredominant population-based cohort from Olmsted County, Minnesota. Overall, the incidence rate was 10.0 per 100,000 population, which suggested that sarcoidosis is less common in Caucasians than in Blacks, but is more common in Caucasians than in Asians. Intrathoracic involvement was seen in the vast majority of patients, but less than half have respiratory symptoms...
May 22, 2017: Reumatismo
https://www.readbyqxmd.com/read/28535301/life-events-and-black-white-differences-in-adult-children-s-financial-assistance-to-mothers
#14
Sung S Park
Background and Objectives: Parents who experience life events with negative economic consequences may rely on adult children for financial assistance. This study provided national estimates of Black and White mothers' financial help from adult children. It also examined whether the Black-White difference in the likelihood of a mother's receipt of financial assistance persisted after accounting for life events reflecting parental need and children's ability to provide help. Research Design and Methods: The Health and Retirement Study was used to examine late middle aged (51-70) Black and White mothers' financial help from adult children...
May 23, 2017: Gerontologist
https://www.readbyqxmd.com/read/28535297/antihypertensive-adherence-trajectories-among-older-adults-in-the-first-year-after-initiation-of-therapy
#15
Jennifer L Hargrove, Virginia Pate, Carri H Casteel, Yvonne M Golightly, Laura R Loehr, Stephen W Marshall, Til Stürmer
BACKGROUND: Adherence to antihypertensives is suboptimal, but previous methods of quantifying adherence fail to account for varying patterns of use over time. We sought to improve classification of antihypertensive adherence using group-based trajectory models, and to determine whether individual factors predict adherence trajectories. METHODS: We identified older adults initiating antihypertensive therapy during 2008-2011 using a 20% sample of Medicare (federal health insurance available to US residents over the age of 65) beneficiaries enrolled in parts A (inpatient services), B (outpatient services), and D (prescription medication)...
May 23, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28535247/physical-and-physiological-factors-influence-behavioral-responses-of-cochliomyia-macellaria-diptera-calliphoridae-to-synthetic-attractants
#16
M F Chaudhury, J J Zhu, S R Skoda
Volatile chemicals from waste artificial larval media as well as from bovine blood inoculated with bacteria isolated from screwworm-infested wounds attract gravid females of Cochliomyia hominivorax Coquerel and Cochliomyia macellaria (F.). Chemicals identified from volatiles are dimethyl disulfide, dimethyl trisulfide, phenol, p-cresol, and indole; a blend of these attracted females to oviposit. Present studies investigated the effectiveness of these compounds, either in a blend or individually as potential oviposition attractants...
May 23, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28535171/cumulative-lactation-and-onset-of-hypertension-in-african-american-women
#17
Ellen M Chetwynd, Alison M Stuebe, Lynn Rosenberg, Melissa Troester, Diane Rowley, Julie R Palmer
Hypertension affects nearly one of three women and contributes to cardiovascular disease, the leading cause of death in the United States. Breastfeeding leads to metabolic changes that could reduce risks of hypertension. Hypertension disproportionately affects black women, but rates of breastfeeding lag behind the general population. In the Black Women's Health Study (N = 59,001), we conducted a nested case control analysis using unconditional logistic regression to estimate the association between breastfeeding and incident hypertension at ages 40-65 using data collected from 1995 to 2011...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28534868/a-new-long-term-daily-satellite-based-rainfall-dataset-for-operational-monitoring-in-africa
#18
Ross I Maidment, David Grimes, Emily Black, Elena Tarnavsky, Matthew Young, Helen Greatrex, Richard P Allan, Thorwald Stein, Edson Nkonde, Samuel Senkunda, Edgar Misael Uribe Alcántara
Rainfall information is essential for many applications in developing countries, and yet, continually updated information at fine temporal and spatial scales is lacking. In Africa, rainfall monitoring is particularly important given the close relationship between climate and livelihoods. To address this information gap, this paper describes two versions (v2.0 and v3.0) of the TAMSAT daily rainfall dataset based on high-resolution thermal-infrared observations, available from 1983 to the present. The datasets are based on the disaggregation of 10-day (v2...
May 23, 2017: Scientific Data
https://www.readbyqxmd.com/read/28534836/differentiation-and-structure-in-sulfolobus-islandicus-rod-shaped-virus-populations
#19
Maria A Bautista, Jesse A Black, Nicholas D Youngblut, Rachel J Whitaker
In the past decade, molecular surveys of viral diversity have revealed that viruses are the most diverse and abundant biological entities on Earth. In culture, however, most viral isolates that infect microbes are represented by a few variants isolated on type strains, limiting our ability to study how natural variation affects virus-host interactions in the laboratory. We screened a set of 137 hot spring samples for viruses that infect a geographically diverse panel of the hyperthemophilic crenarchaeon Sulfolobus islandicus...
May 19, 2017: Viruses
https://www.readbyqxmd.com/read/28534474/influence-of-nanoscale-topology-on-bactericidal-efficiency-of-black-silicon-surfaces
#20
Denver P Linklater, Huu Khuong Duy Nguyen, Chris M Bhadra, Saulius Juodkazis, Elena P Ivanova
The nanostructuring of materials to create bactericidal and antibiofouling surfaces presents an exciting alternative to common methods of preventing bacterial adhesion. The fabrication of synthetic bactericidal surfaces has been inspired by the anti-wetting and anti-biofouling properties of insect wings, and other topologies found in nature. Black silicon is one such synthetic surfaces which has established bactericidal properties. In this study we show that time-dependent plasma etching of silicon wafers using 15, 30, and 45 min etching intervals, is able to produce different surface geometries with linearly increasing heights of approximately 280, 430, and 610 nm, respectively...
May 23, 2017: Nanotechnology
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