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J R Griswold, D G Medvedev, J W Engle, R Copping, J M Fitzsimmons, V Radchenko, J C Cooley, M E Fassbender, D L Denton, K E Murphy, A C Owens, E R Birnbaum, K D John, F M Nortier, D W Stracener, L H Heilbronn, L F Mausner, S Mirzadeh
Actinium-225 and (213)Bi have been used successfully in targeted alpha therapy (TAT) in preclinical and clinical research. This paper is a continuation of research activities aiming to expand the availability of (225)Ac. The high-energy proton spallation reaction on natural thorium metal targets has been utilized to produce millicurie quantities of (225)Ac. The results of sixteen irradiation experiments of thorium metal at beam energies between 78 and 192MeV are summarized in this work. Irradiations have been conducted at Brookhaven National Laboratory (BNL) and Los Alamos National Laboratory (LANL), while target dissolution and processing was carried out at Oak Ridge National Laboratory (ORNL)...
September 28, 2016: Applied Radiation and Isotopes
Achilleas Boutsiadis, Laurent Baverel, Hubert Lenoir, Philippe Delsol, Johannes Barth
Chronic acromioclavicular (AC) instability is a rare posttraumatic shoulder condition that can lead to undesirable symptoms like persistent pain, muscle fatigue, loss of strength, or even scapular dyskinesis. It is well known that in these cases the superior functional results depend on the restoration of the anatomy and stability of the AC joint in both vertical and horizontal planes. Considering the ligaments degeneration and atrophy in chronic AC joint dislocations, we present an arthroscopic-assisted reconstruction of both the coracoclavicular and AC ligaments using autograft augmentation...
October 21, 2016: Techniques in Hand & Upper Extremity Surgery
Zhe Wang, Fuwu Zhang, Zhantong Wang, Xiao Fu, Albert Jin, Bryant C Yung, Jing Fan, Xiangyu Yang, Gang Niu, Xiaoyuan Chen
Molecular design of biomaterials with unique features reca-pitulating nature's niche to influence biological activities has been a prolific area of investigation in chemistry and material science. The extracellular matrix (ECM) provides a wealth of bioactive molecules in supporting cell proliferation, migra-tion and differentiation. The well-patterned fibril and inter-twining architecture of the ECM profoundly influences cell behavior and development. Inspired by those features from the ECM, we attempted to integrate essential biological fac-tors from the ECM to design bioactive molecules to construct artificial self-supportive ECM mimics to advance stem cell culture...
October 24, 2016: Journal of the American Chemical Society
Sukanta Das, Jaswinder Singh Maras, Shabir Hussain, Shvetank Sharma, Paul David, S Sukriti, Shasthry S M, Rakhi Maiwall, Nirupama Trehanpati, T P Singh, Shiv Kumar Sarin
BACKGROUND AND AIMS: Albumin is a potent scavenger of reactive oxygen species (ROS). However, modifications in albumin structure may reduce its antioxidant properties and modulate its immune-regulatory functions. We examined alterations in circulating albumin in severe alcoholic hepatitis (SAH) patients and its contribution in neutrophil activation, intracellular stress plus alteration in associated molecular-pathways. PATIENTS AND METHODS: Albumin modifications and plasma oxidative-stress were assessed in SAH (n=90), alcoholic cirrhosis (AC, n=60) and healthy control (HC, n=30) using LC/MS and spectrophotometry...
October 24, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Richard Ac Hughes, Ruth Brassington, Angela A Gunn, Pieter A van Doorn
BACKGROUND: Guillain-Barré syndrome (GBS) is an acute paralysing disease caused by inflammation of the peripheral nerves, which corticosteroids would be expected to benefit. OBJECTIVES: To examine the ability of corticosteroids to hasten recovery and reduce the long-term morbidity from GBS. SEARCH METHODS: On 12 January 2016, we searched the Cochrane Neuromuscular Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and Embase...
October 24, 2016: Cochrane Database of Systematic Reviews
Bin Jia, Tao Sun, Ming Xin
In this paper, a distributed cubature Gaussian mixture filter (DCGMF) based on an iterative diffusion strategy (DCGMF-ID) is proposed for multisensor estimation and information fusion. The uncertainties are represented as Gaussian mixtures at each sensor node. A high-degree cubature Kalman filter provides accurate estimation of each Gaussian mixture component. An iterative diffusion scheme is utilized to fuse the mean and covariance of each Gaussian component obtained from each sensor node. The DCGMF-ID extends the conventional diffusion-based fusion strategy by using multiple iterative information exchanges among neighboring sensor nodes...
October 20, 2016: Sensors
Petra Břehová, Markéta Šmídková, Jan Skácel, Martin Dračínský, Helena Mertlíková-Kaiserová, Monica P Soto Velasquez, Val J Watts, Zlatko Janeba
Bordetella pertussis adenylate cyclase toxin (ACT) and Bacillus anthracis edema factor (EF) are key virulence factors with adenylate cyclase (AC) activity that substantially contribute to the pathogenesis of whooping cough and anthrax, respectively. There is an urgent need to develop potent and selective inhibitors of bacterial ACs with prospects for the development of potential antibacterial therapeutics and to study their molecular interactions with the target enzymes. Novel fluorescent 5-chloroanthraniloyl-substituted acyclic nucleoside phosphonates (Cl-ANT-ANPs) were designed and synthesized in the form of their diphosphates (Cl-ANT-ANPpp) as competitive ACT and EF inhibitors with sub-micromolar potency (IC50 values: 11-622 nm)...
October 24, 2016: ChemMedChem
Patrick S Walsh, Karl N Blodgett, Carl McBurney, Samuel H Gellman, Timothy S Zwier
Gas-phase single-conformation spectroscopy is used to study Ac-Gln-Gln-NHBn in order to probe the interplay between sidechain hydrogen bonding and backbone conformational preferences. This small, amide-rich peptide offers many possibilities for backbone-backbone, sidechain-backbone, and sidechain-sidechain interactions. The major conformer observed experimentally features a type-I β-turn with a canonical 10-membered ring C=O-H-N hydrogen bond between backbone amide groups. In addition, the C=O group of each Gln sidechain participates in a seven-membered ring hydrogen bond with the backbone NH of the same residue...
October 24, 2016: Angewandte Chemie
Dahao Jiang, Xianyuan Wu, Jun Mao, Jun Ni, Xiaonian Li
Cu-CeO2/AC catalysts exhibited extraordinary catalytic performance in the upgradation of ethanol to n-butanol. To the best of our knowledge, this is the first report that the highest n-butanol yields of 21.6% and nearly 20% could be achieved over heterogeneous catalysts under mild reaction conditions in batch and fixed-bed reactors, respectively. The high catalytic activity, selectivity and stability of these catalysts could be ascribed to the synergy of Cu, CeO2 and the activated carbon support.
October 24, 2016: Chemical Communications: Chem Comm
J Gerenova, S Stanilova
Functional genetic polymorphisms that altered gene expression of cytokines are candidate genetic factors that could modulate the development and progression of Hashimoto's thyroiditis (HT). IL-12B gene encoded the IL-12p40 subunit, which is included in the pro-inflammatory heterodimeric cytokines IL-12p70 and IL-23. IL-10 is an important Treg cytokine suppressing inflammatory cytokine production and autoimmunity. This study was designed to compare -1082A/GIL-10 and +1188A/C3'UTRIL-12B genotype distribution in 130 patients with HT to a group of 157 healthy controls in attempts to determine an association with HT development...
October 24, 2016: International Journal of Immunogenetics
Kiyotaka Yanagihara, Yoshiharu Kinugasa, Kinya Shirota, Yoshiaki Inoue, Hiroshige Ishii, Fumiyo Tsunoda, Masaaki Iwata, Shinobu Sugihara, Shinya Takeda, Masayuki Hirai, Asao Mimura, Masahiko Kato, Kazuhiro Yamamoto
AIMS: Inadequate self-care management is a leading cause of re-hospitalization in patients with heart failure (HF). Psychological factors such as some ego functions interfere with self-care behaviour modification, leading to poor outcomes in patients with several chronic diseases. However, characteristics of ego states in patients with repeated hospitalization for HF remain undefined. METHODS AND RESULTS: The present study enrolled 40 HF outpatients with previous history of HF hospitalization and receiving self-care management...
March 2016: ESC Heart Failure
Hatice Zehra Akbas, Zeki Aydin, Onur Yilmaz, Selvin Turgut
The effects of the homogenization process on the structures and dielectric properties of pure and Nb-doped BaTiO3 ceramics have been investigated using an ultrasonic homogenization and conventional mechanical methods. The reagents were homogenized using an ultrasonic processor with high-intensity ultrasonic waves and using a compact mixer-shaker. The components and crystal types of the powders were determined by Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analyses. The complex permittivity (ε('), ε″) and AC conductivity (σ') of the samples were analyzed in a wide frequency range of 20Hz to 2MHz at room temperature...
January 2017: Ultrasonics Sonochemistry
Ebrahim Alipanahpour Dil, Mehrorang Ghaedi, Arash Asfaram
The present research is focused on the synthesis and characterization of zinc (II) oxide nanorods loaded on activated carbon (ZnO-NRs-AC) to prepare an outstanding adsorbent for the simultaneous adsorption of heavy metals and dyes as hazardous pollutant using ultrasound energy. The adsorbent was identified by Scanning Electron Microscope (SEM), Transmission Electron Microscopy (TEM), Energy-dispersive X-ray spectroscopy (EDS) and X-ray diffraction (XRD) analysis. The individual effects and possible interactions between the most effective variables including initial metal ions (Cd(2+) and Co(2+)) and azo dyes (methylene blue (MB) and crystal violet (CV)) concentration, adsorbent dosage and ultrasonic time on the responses were investigated by response surface methodology (RSM) and optimum conditions was fixed at Cd(2+), Co(2+), MB and CV concentrations were 25, 24, 18 and 14mgL(-1), respectively, 0...
January 2017: Ultrasonics Sonochemistry
Ebrahim Alipanahpour Dil, Mehrorang Ghaedi, Arash Asfaram, Shaaker Hajati, Fatemeh Mehrabi, Alireza Goudarzi
Copper oxide nanoparticle-loaded activated carbon (CuO-NP-AC) was synthesized and characterized using different techniques such as FE-SEM, XRD and FT-IR. It was successfully applied for the ultrasound-assisted simultaneous removal of Pb(2+) ions and malachite green (MG) dye in binary system from aqueous solution. The effect of important parameters was modeled and optimized by artificial neural network (ANN) and response surface methodology (RSM). Maximum simultaneous removal percentages (>99.0%) were found at 25mgL(-1), 20mgL(-1), 0...
January 2017: Ultrasonics Sonochemistry
Somayeh Dashamiri, Mehrorang Ghaedi, Arash Asfaram, Fahimeh Zare, Shaobin Wang
This paper focuses on the development of an effective methodology to obtain the optimum removal conditions assisted by ultrasonics to maximize the simultaneous removal of dyes, eosin Y (EY), methylene blue (MB) and phenol red (PR), by Cu(OH)2-NP-AC in aqueous solution using response surface methodology (RSM). The effects of variables such as pH, initial dyes concentrations (mgL(-1)), and amount of sorbent (mg) and sonication time (min) on the dyes removal were studied. A central composite design (CCD) was applied to evaluate the interactive effects of adsorption variables...
January 2017: Ultrasonics Sonochemistry
Sonia Bahrani, Mehrorang Ghaedi, Mohammad Javad Khoshnood Mansoorkhani, Arash Asfaram, Ali Akbar Bazrafshan, Mihir Kumar Purkait
The present research focus on designing an appropriate dispersive solid-phase microextraction (UA-DSPME) for preconcentration and determination of Eriochrome Cyanine R (ECR) in aqueous solutions with aid of sonication using lead (II) dioxide nanoparticles loaded on activated carbon (PbO-NPs-AC). This material was fully identified with XRD and SEM. Influence of pH, amounts of sorbent, type and volume of eluent, and sonication time on response properties were investigated and optimized by central composite design (CCD) combined with surface response methodology using STATISTICA...
January 2017: Ultrasonics Sonochemistry
Ahmad Reza Bagheri, Mehrorang Ghaedi, Arash Asfaram, Ali Akbar Bazrafshan, Ramin Jannesar
The present study the ultrasound assisted adsorption of dyes in single system onto Fe3O4 magnetite nanoparticles loaded on activated carbon (Fe3O4-MNPs-AC) was described following characterization and identification of this adsorbent by conventional techniques likes field emission scanning electron microscopy, transmission electron microscopy, particle-size distribution, X-ray diffraction and Fourier transform infrared spectroscopy. A central composite design in conjunction with a response surface methodology according to f-test and t-test for recognition and judgment about significant term led to construction of quadratic model which represent relation among responses and effective terms...
January 2017: Ultrasonics Sonochemistry
Arash Asfaram, Mehrorang Ghaedi, Shaaker Hajati, Alireza Goudarzi, Ebrahim Alipanahpour Dil
The ultrasound-assisted simultaneous adsorption of brilliant green (BG) and malachite green (MG) onto Mn-doped Fe3O4 nanoparticle-loaded activated carbon (Mn-Fe3O4-NP-AC) as a novel adsorbent was investigated and analyzed using first derivative spectrophotometry. The adsorbent was characterized using FT-IR, FE-SEM, EDX and XRD. Plackett-Burman design was applied to reduce the total number of experiments and to optimize the ultrasound-assisted simultaneous adsorption procedure, where pH, adsorbent mass and sonication time (among six tested variables) were identified as the most significant factors...
January 2017: Ultrasonics Sonochemistry
Massimiliano Berretta, Raffaele Di Francia, Brigida Stanzione, Gaetano Facchini, Arben LLeshi, Paolo De Paoli, Michele Spina, Umberto Tirelli
The introduction of Highly Active Antiretroviral Therapy (HAART) into clinical practice has dramatically changed the outcome of HIV-infected patients by prolonging their survival. The increase in life expectancy has led to an increased risk of non-AIDS-related mortality and morbidity, including cardiovascular diseases, neurocognitive diseases, neuroendocrine dysfunctions and cancer. Areas Covered: The GICAT (Italian Cooperation Group on AIDS and Tumors) has demonstrated that patients who receive a multidisciplinary approach with the combination of anticancer agents (AC) and HAART can achieve better responses and survival rates than patients who receive AC alone...
October 22, 2016: Expert Opinion on Pharmacotherapy
Sean Page, Ian Davies-Abbott, Mat Phillips
Dementia Care Mapping™ is widely acknowledged as the gold standard observational method that can support the introduction of person centred care into a variety of settings ( It encourages care staff to think about how the person with dementia is experiencing the care provided and the care setting. It has been shown to raise care staff awareness sufficiently to bring about improvements in care. In this paper, we describe a programme of work in North Wales that seeks to find innovative ways to use Dementia Care Mapping™, in acute mental health admission wards for people affected by dementia, and we set out some of those innovations...
October 21, 2016: Dementia
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