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https://www.readbyqxmd.com/read/28723966/activated-carbon-a-useful-medium-to-bind-chlordecone-in-soil-and-limit-its-transfer-to-growing-goat-kids
#1
Sarah Yehya, Matthieu Delannoy, Agnès Fournier, Moomen Baroudi, Guido Rychen, Cyril Feidt
Chlordecone (Kepone) (CLD) is a highly persistent pesticide which was extensively used in the French West Indies; high levels of CLD can still currently be found in large agricultural areas. As CLD transfers from soil to animals mainly via involuntary ingestion, the consumption of foodstuffs derived from animals raised in contaminated areas may significantly contribute to exposure of humans to CLD. The present study was designed to test the efficacy of two different activated carbons (ACs) sources in limiting CLD transfer from soil to animal...
2017: PloS One
https://www.readbyqxmd.com/read/28723662/acetyl-lupeolic-acid-inhibits-akt-signaling-and-induces-apoptosis-in-chemoresistant-prostate-cancer-cells-in-vitro-and-in-vivo
#2
Claudia Schmidt, Cornelia Loos, Lu Jin, Michael Schmiech, Christoph Q Schmidt, Menna El Gaafary, Tatiana Syrovets, Thomas Simmet
The triterpenoid acetyl-lupeolic acid (ac-LA) isolated from the oleogum resin of Boswellia carterii reduced the viability of a panel of cancer cell lines more efficiently than lupeol. There was no detectable intracellular conversion of ac-LA to lupeol and vice versa. In contrast to docetaxel, ac-LA did not induce selection of treatment-resistant cancer cells. By various parameters including DNA fragmentation, ac-LA was shown to induce apoptosis in androgen-independent PC-3 cells, whereas in MDA-MB-231 breast cancer cells, ac-LA led to cell accumulation in the G2/M phase of the cell cycle, but not to apoptosis...
July 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28723591/molecular-characterization-and-expression-analysis-of-the-myostatin-gene-and-its-association-with-growth-traits-in-noble-scallop-chlamys-nobilis
#3
Sigang Fan, Youhou Xu, Baosuo Liu, Wenyao He, Bo Zhang, Jiaqi Su, Dahui Yu
Myostatin (MSTN), also called growth and differentiation factor-8 (GDF-8), is a member of the transforming growth factor-β (TGF-β) superfamily and an inhibitor of muscle differentiation and growth. In this report, we identified and characterized a MSTN gene (CnMSTN) from the scallop Chlamys nobilis. The open reading frame of CnMSTN was 1374bp in length, encoding 457 amino acids. The structure of CnMSTN included a putative signal peptide, a TGF-β propeptide domain, and a conserved TGF-β domain. Phylogenetic analysis showed that the CnMSTN gene was clustered in the same subgroup with the MSTN gene found in Mollusca...
July 16, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28722825/crystalline-%C3%AF-stack-containing-five-stereoisomers-insights-into-conformational-isomorphism-chirality-inversion-and-disorder
#4
Agnieszka Nowak-Krol, Merle Röhr, David Schmidt, Frank Würthner
An unprecedented crystal packing arrangement of a tetramethoxy-bay-substituted perylene bisimide (PBI) consists of three crystallographically independent molecules, i.e. an achiral (AC) PBI of saddle-shaped geometry along with two pairs of propeller-like twisted (P) and (M)enantiomeric PBI frameworks. All these five conformations are observed within a single π-stack revealing an intriguing packing sequence with an inversion of chirality from P to M via AC. Nudged elastic band calculations for the isolated molecule show that AC is a local minimum of the P to M interconversion path...
July 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28722823/rational-design-of-a-highly-potent-and-selective-peptide-inhibitor-of-pace4-by-salt-bridge-interaction-with-d160-at-position-p3
#5
Vahid Dianati, Azar Shamloo, Anna Kwiatkowska, Roxane Desjardins, Armand Soldera, Robert Day, Yves L Dory
PACE4, a member of the proprotein convertases (PCs) family of serine proteases, is a validated target for prostate cancer. Our group has developed a potent and selective PACE4 inhibitor: Ac-LLLLRVKR-NH2 . In seeking for modifications to increase the selectivity of this ligand toward PACE4, we replaced one of its P3 Val methyl groups with a basic group capable of forming a salt bridge with D160 of PACE4. The resulting inhibitor is eight times more potent than the P3 Val parent inhibitor and two times more selective over furin, because the equivalent salt bridge with furin E257 is not optimal...
July 19, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28722783/the-association-of-the-placental-mthfr-3-utr-polymorphisms-promoter-methylation-and-mthfr-expression-with-preeclampsia
#6
Abbas Mohammadpour-Gharehbagh, Batool Teimoori, Mehrnaz Narooei-Nejad, Mehrnaz Mehrabani, Ramin Saravani, Saeedeh Salimi
Preeclampsia (PE) is a pregnancy specific complication arises in presence of the placenta and disappears immediately after delivery. Therefore, the aim of the present study was to investigate the possible effects of the placental 3'-UTR rs1537514C>G and rs4846049 C>A polymorphisms and DNA methylation of the MTHFR gene on the MTHFR mRNA expression. The placenta of 74 PE pregnant women and 75 normotensive pregnant women were collected after delivery. The methylation status of the MTHFR promoter was assessed with Methylation Specific PCR(MSP)...
July 19, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28721684/pharmacokinetics-microscale-distribution-and-dosimetry-of-alpha-emitter-labeled-anti-pd-l1-antibodies-in-an-immune-competent-transgenic-breast-cancer-model
#7
Jessie R Nedrow, Anders Josefsson, Sunju Park, Tom Bäck, Robert F Hobbs, Cory Brayton, Frank Bruchertseifer, Alfred Morgenstern, George Sgouros
BACKGROUND: Studies combining immune checkpoint inhibitors with external beam radiation have shown a therapeutic advantage over each modality alone. The purpose of these works is to evaluate the potential of targeted delivery of high LET radiation to the tumor microenvironment via an immune checkpoint inhibitor. METHODS: The impact of protein concentration on the distribution of (111)In-DTPA-anti-PD-L1-BC, an (111)In-antibody conjugate targeted to PD-L1, was evaluated in an immunocompetent mouse model of breast cancer...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28720161/validity-of-the-american-college-of-surgeons-national-surgical-quality-improvement-program-risk-calculator-in-south-australian-glossectomy-patients
#8
S S Kao, C Frauenfelder, D Wong, S Edwards, S Krishnan, E H Ooi
BACKGROUND: Appropriate selection of tongue cancer patients considering surgery is critical in ensuring optimal outcomes. The American College of Surgeons' National Surgical Quality Improvement Program ('ACS-NSQIP') risk calculator was developed to assess patients' 30-day post-operative risk, providing surgeons with information to guide decision making. METHOD: A retrospective review of 30-day actual mortality and morbidity of tongue cancer patients was undertaken to investigate the validity of this tool for South Australian patients treated from 2005 to 2015...
July 19, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28719900/second-to-third-trimester-longitudinal-growth-assessment-for-the-prediction-of-largeness-for-gestational-age-and-macrosomia-in-an-unselected-population
#9
Javier Caradeux, Elisenda Eixarch, Edurne Mazarico, Tri Rahmat Basuki, Eduard Gratacós, Francesc Figueras
BACKGROUND: Prenatal detection of excessive growth remains inaccurate. Most strategies rely on a single cross-sectional evaluation of fetal size during the third trimester. OBJECTIVES: To compare second- to third-trimester longitudinal growth assessment with cross-sectional evaluation at the third trimester in the prediction of largeness for gestational age (LGA) and macrosomia. METHODS: A cohort of 2,696 unselected singleton pregnancies scanned at 21 ± 2 and 32 ± 2 weeks was created...
July 13, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28718938/quality-control-of-ultrasound-for-fetal-biometry-results-from-the-intergrowth-21-st-project
#10
Angelo Cavallaro, Stephen T Ash, Raffaele Napolitano, Sikolia Wanyonyi, Eric O Ohuma, Malid Molloholli, Joyce Sande, Ippokratis Sarris, Christos Ioannou, Tess Norris, Vera Donadono, Maria Carvalho, Manorama Purwar, Fernando C Barros, Yasmin A Jaffer, Enrico Bertino, Ruyan Pang, Michael G Gravett, Laurent J Salomon, Julia Alison Noble, Douglas G Altman, Aris T Papageorghiou
OBJECTIVES: To assess a comprehensive package of ultrasound quality control in a large multicentre study of fetal growth - the Fetal Growth Longitudinal Study of the INTERGROWTH-21(st) Project. METHODS: We performed quality control (QC) measures on 20,313 ultrasound scan images taken prospectively from 4,321 fetuses at 14-41 weeks' gestation in eight geographical locations. At the time of each ultrasound examination, three fetal biometric variables were measured in triplicate on separately generated images: head circumference (HC), abdominal circumference (AC) and femur length (FL)...
July 18, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28718387/for-more-events-and-to-book-online-please-visit-www-rsm-ac-uk-diary
#11
(no author information available yet)
No abstract text is available yet for this article.
July 2017: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/28718094/distribution-source-analysis-and-ecological-risk-assessment-of-polycyclic-aromatic-hydrocarbons-in-the-typical-topsoil-of-the-issyk-kul-lake-basin
#12
Wen Liu, Long Ma, Jilili Abuduwaili, Yaoming Li
The concentration, distribution, compositional characteristics, and pollution sources of 16 polycyclic aromatic hydrocarbons (PAHs) in the topsoil of Issyk-Kul Lake Basin were studied, and their ecological risks were evaluated in this paper. The total concentration of the 16 PAHs was 68.58-475.95 ng g(-1), with an average of 134.45 ng g(-1). Four-ring PAHs accounted for 43.2% of the total PAHs, two- and three-ring PAHs accounted for 39.4%, and five- and six-ring PAHs accounted for 15.8%. The total concentration of the seven carcinogenic PAHs was 7...
August 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28717889/combined-arthroscopically-assisted-coraco-and-acromioclavicular-stabilization-of-acute-high-grade-acromioclavicular-joint-separations
#13
Carmen Hann, Natascha Kraus, Marvin Minkus, Nina Maziak, Markus Scheibel
PURPOSE AND HYPOTHESIS: Due to high rate of persisting dynamic posterior translation (DPT) following isolated coracoclavicular double-button technique for reconstruction of the acromioclavicular (AC) joint reported in the literature, an additional acromioclavicular cerclage was added to the procedure. The aim of this study was to evaluate the clinical and radiological results of patients with high-grade AC-joint instability treated with a double TightRope technique with an additional percutaneous acromioclavicular cerclage...
July 17, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28717347/effect-of-eicosapentaenoic-acids-rich-fish-oil-supplementation-on-motor-nerve-function-after-eccentric-contractions
#14
Eisuke Ochi, Yosuke Tsuchiya, Kenichi Yanagimoto
BACKGROUND: This study investigated the effect of supplementation with fish oil rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the M-wave latency of biceps brachii and muscle damage after a single session of maximal elbow flexor eccentric contractions (ECC). METHODS: Twenty-one men were completed the randomized, double-blind, placebo-controlled, and parallel-design study. The subjects were randomly assigned to the fish oil group (n = 10) or control group (n = 11)...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28717298/ameloblastic-carcinoma-a-rare-malignant-tumour-in-maxillofacial-region
#15
Pushkar Devidas Gawande, Kiran Khande, Gaurav Agrawal, Amita Aditya
Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor with poor prognosis. It has an aggressive clinical course with extensive local destruction. It occurs primarily in the mandible. It may clinically present as a cystic lesion with benign clinical feature or as a large mass with ulceration, significant bone resorption and mobility of teeth in the affected region. Reliable evidence of it's biological activity along with extensive local destruction, direct extension of tumor, lymph node involvement and metastasis to various sites (frequently lung) have been reported...
September 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28717262/three-dimensional-graphene-nanosheets-as-cathode-catalysts-in-standard-and-supercapacitive-microbial-fuel-cell
#16
Carlo Santoro, Mounika Kodali, Sadia Kabir, Francesca Soavi, Alexey Serov, Plamen Atanassov
Three-dimensional graphene nanosheets (3D-GNS) were used as cathode catalysts for microbial fuel cells (MFCs) operating in neutral conditions. 3D-GNS catalysts showed high performance towards oxygen electroreduction in neutral media with high current densities and low hydrogen peroxide generation compared to activated carbon (AC). 3D-GNS was incorporated into air-breathing cathodes based on AC with three different loadings (2, 6 and 10 mgcm(-2)). Performances in MFCs showed that 3D-GNS had the highest performances with power densities of 2...
July 15, 2017: Journal of Power Sources
https://www.readbyqxmd.com/read/28717248/loss-of-type-9-adenylyl-cyclase-triggers-reduced-phosphorylation-of-hsp20-and-diastolic-dysfunction
#17
Yong Li, Tanya A Baldwin, Yan Wang, Janani Subramaniam, Anibal Garza Carbajal, Cameron S Brand, Shane R Cunha, Carmen W Dessauer
Adenylyl cyclase type 9 (AC9) is found tightly associated with the scaffolding protein Yotiao and the IKs ion channel in heart. But apart from potential IKs regulation, physiological roles for AC9 are unknown. We show that loss of AC9 in mice reduces less than 3% of total AC activity in heart but eliminates Yotiao-associated AC activity. AC9(-/-) mice exhibit no structural abnormalities but show a significant bradycardia, consistent with AC9 expression in sinoatrial node. Global changes in PKA phosphorylation patterns are not altered in AC9(-/-) heart, however, basal phosphorylation of heat shock protein 20 (Hsp20) is significantly decreased...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717193/adhesive-capsulitis-of-the-shoulder-evaluation-with-us-arthrography-using-a-sonographic-contrast-agent
#18
Xueqing Cheng, Zhenqi Zhang, Guo Xuanyan, Tingting Li, Juan Li, Longlin Yin, Man Lu
Adhesive capsulitis (AC) is a painful and disabling disorder, which caused restricted motion and chronic pain of shoulder. Intracavitary contrast-enhanced ultrasound has been recently applied to assess obstructive bile duct diseases, tubal patency, vesicoureteric reflux and so on. The aim of this study was to detect the value of US-arthrography by injecting the contrast agent SonoVue into glenohumeral joint compared with US in diagnosing AC. Utrasound (US) and US-arthrography images of 45 patients with AC were compared with that of 45 control subjects without AC with MRI as a gold standard...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28715181/structural-insights-into-selective-ligand-receptor-interactions-leading-to-receptor-inactivation-utilizing-selective-melanocortin-3-receptor-antagonists
#19
Minying Cai, Udaya Kiran Marelli, Blake Mertz, Johannes G Beck, Florian Opperer, Florian Rechenmacher, Horst Kessler, Victor J Hruby
Systematic N-methylated derivatives of the melanocortin receptor ligand, SHU9119, lead to mul-tiple binding and functional selectivity towards melanocortin receptors. However, the relationship between N-methylation-induced conformational changes in the peptide backbone and side chains and melanocortin receptor selectivity is still unknown. We conducted comprehensive conforma-tional studies in solution of two selective antagonists of the third isoform of the melanocortin re-ceptor (hMC3R), namely, Ac-Nle-c[Asp-NMe-His6-D-Nal(2')7-NMe-Arg8-Trp9-Lys]-NH2 (15) and Ac-Nle-c[Asp-His6-D-Nal(2')7-NMe-Arg8-NMe-Trp9-NMe-Lys]-NH2 (17)...
July 17, 2017: Biochemistry
https://www.readbyqxmd.com/read/28714460/magnetic-behavior-of-metallic-kagome-lattices-tb3ru4al12-and-er3ru4al12
#20
Sanjay Kumar Upadhyay, Kartik K Iyer, E V Sampathkumaran
We report the magnetic behavior of two intermetallic-based kagome lattices, Tb3Ru4Al12 and Er3Ru4Al12, crystallizing in the Gd3Ru4Al2-type hexagonal crystal structure, by measurements in the range 1.8-300 K with bulk experimental techniques (ac and dc magnetization, heat capacity, and magnetoresistance). The main finding is that the Tb compound, known to order antiferromagnetically below (T N =) 22 K, shows glassy characteristics at lower temperatures ([Formula: see text]15 K), thus characterizing this compound as a re-entrant spin-glass...
July 17, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
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