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Alfonso Vasquez-Perez, Francesco Matarazzo, Niraj Mandal, Stephen Tuft
PURPOSE: To describe a case of acute glaucoma after cyanoacrylate gluing for a non-traumatic central corneal perforation. METHODS: A 55-year-old woman with history of rheumatoid arthritis and severe dry eye presented to emergency with a right central corneal perforation. She was treated successfully with the use cyanoacrylate glue patch but iridocorneal adhesions remained. The next day she presented with ocular pain, headaches and vomiting. On examination she had shallow anterior chamber with no aqueous leakage but her intraocular pressure was 56▒mm Hg measured with rebound tonometry...
June 18, 2018: Journal of Glaucoma
Dan-Ni Cao, Jing-Jing Shi, Ning Wu, Jin Li
Chronic exposure to morphine can produce tolerance, dependence and addiction, but the underlying neurobiological basis is still incompletely understood. c-Jun, as an important component of the activator protein-1 transcription factor, is supposed to take part in regulating gene expression in AC/cAMP/PKA signaling. MicroRNA (miRNA) has emerged as a critical regulator of neuronal functions. Although a number of miRNAs have been reported to regulate the μ-opioid receptor expression, there has been no report about miRNAs to regulate chronic morphine-induced, naloxone-precipitated cAMP overshoot...
June 18, 2018: Metabolic Brain Disease
Bernhard Scheiner, Paul René Stammet, Sebastian Pokorny, Theresa Bucsics, Philipp Schwabl, Andrea Brichta, Johannes Thaler, Katharina Lampichler, Ahmed Ba-Ssalamah, Cihan Ay, Arnulf Ferlitsch, Michael Trauner, Mattias Mandorfer, Thomas Reiberger
BACKGROUND: Non-malignant portal vein thrombosis (PVT) is common in patients with advanced liver disease. Anticoagulation (AC) increases the chances of recanalization and may improve liver function in patients with cirrhosis. AIM: We retrospectively assessed the course of non-malignant PVT in patients receiving AC. METHODS: Parameters related to hepatic injury (aspartate aminotransferase [AST]/alanine aminotransferase [ALT]), severity of disease (ascites) and synthesis function (albumin) as well as AC, rates of PVT regression/progression and AC-associated complications were documented...
June 18, 2018: Wiener Klinische Wochenschrift
Shou-Wu Lee, Han-Chung Lien, Chi-Chen Lin, Mei-Chin Wen, Chi-Sen Chang
Background: The aim of this study was to investigate the expression of transforming growth factor β (TGF-β) in the different stages of Barrett's esophagus (BE). Methods: Paired endoscopic esophageal biopsy samples were obtained from patients with BE prospectively. Subjects were classified into three groups: BE, BE with dysplasia, and adenocarcinoma (AC) arising from BE. Biopsy specimens over normal esophageal epithelium and gastric cardiac epithelium of limited cases were done...
June 2018: Gastroenterology Research
Lei Lei, Zhiming Jiang, Gu Zhang, Qiaoyuan Cheng, Hongyang Lu
BACKGROUND: The response to temozolomide (TMZ) treatment in small-cell lung cancer (SCLC) correlated with O(6)-methylguanine -DNA methyltransferase (MGMT) promoter methylation. 1p/19q co-deletion within oligodendroglioma is a responsive predictor for TMZ. Currently, the status of MGMT promoter methylation and 1p/19q co-deletion in pulmonary carcinoid (PC) and large-cell neuroendocrine carcinoma (LCNEC) is not reported. METHODS: Nine PC [two atypical carcinoids (AC), seven typical carcinoids (TC)] and six LCNEC patients were collected retrospectively...
June 18, 2018: World Journal of Surgical Oncology
Ladislav Bumba, Jiri Masin, Adriana Osickova, Radim Osicka, Peter Sebo
The adenylate cyclase toxin-hemolysin (CyaA, ACT, or AC-Hly) plays a crucial role in virulence and airway colonization capacity of the whooping cough agent Bordetella pertussis . The toxin penetrates target cell membranes and exhibits three distinct biological activities. A population of CyaA conformers forms small cation-selective pores that permeabilize the cell membrane for potassium efflux, which can provoke colloid-osmotic (oncotic) cell lysis. The other two activities are due to CyaA conformers that transiently form calcium influx conduits in the target cell membrane and translocate the adenylate cyclase (AC) enzyme into cytosol of cells...
June 16, 2018: Toxins
Vítězslav Kolek, Stanislav Losse, Juraj Kultan, Petr Jakubec, Jaromir Zatloukal, Milan Sova, Marek Szkorupa, Čestmír Neoral, Josef Škarda, Tomáš Tichý, Zdeněk Kolář
OBJECTIVES: Adjuvant chemotherapy (AC) in non-small cell lung cancer (NSCLC) has become a standard of care in patients with stages IIA, IIB, and IIIA after complete tumor resection. Utilization and outcome of AC in routine practice is described in a few studies with non-conclusive results. MATERIAL AND METHODS: This retrospective study included consecutive patients with NSCLC who underwent curative-intent surgery. Data of AC uptake in stage IB (tumor of ≥4 cm in diameter), II and IIIA and reasons of AC omission were evaluated according to medical records...
June 18, 2018: Current Medical Research and Opinion
Sreevatsan Raghavan, Koshi Philip, Puneet Batra, Agneta Marcusson
Objective: To evaluate the influence of dentofacial attractiveness using the 'Psychosocial Impact of Dental Aesthetics Questionnaire' (PIDAQ), Satisfaction with Life Scale (SWLS) and Aesthetic Component (AC) of the Index of Orthodontic Treatment Need (IOTN) in patients with cleft lip/palate (CLP), and non-cleft orthodontic patients (Non-CLP) and their parents. Materials and methods: Eighty patients (aged 11-19 years) comprising 40 CLP and 40 non-CLP were administered the PIDAQ and SWLS questionnaires to be rated individually by the patients, along with IOTN-AC rated by the patients and their parents, respectively...
April 18, 2018: European Journal of Orthodontics
Jyothi Shashidhar, Shashidhar Chandrashekhar
Aims and Objective: The aim of this study was to evaluate the orthodontic treatment need in 11-14-year-old schoolchildren of Central Bengaluru, India, using the index of orthodontic treatment need (IOTN) and to analyze the treatment needs between males and females and correlation between the esthetic to aesthetic (AC) and dental health component (DHC) of IOTN. Materials and Methods: The sample comprised 500 schoolchildren (187 females and 313 males) who had not undergone orthodontic treatment...
May 2018: Journal of International Society of Preventive & Community Dentistry
Peter J Kneuertz, Mohamed K Kamel, Brendon M Stiles, Benjamin E Lee, Mohamed Rahouma, Sebron W Harrison, Nasser K Altorki, Jeffery L Port
BACKGROUND: Pulmonary carcinoid tumors are often considered indolent tumors. The prognostic significance of lymph node (LN) metastases and the need for mediastinal dissection is controversial. We sought to determine the incidence, risk factors, and prognosis of LN metastases in resected carcinoid patients. METHODS: Patients undergoing lung resection for carcinoid and removal of ≥10 LNs were identified in the National Cancer Database form 2004-2014. Typical (TC) and atypical (AC) carcinoids were included...
June 14, 2018: Annals of Thoracic Surgery
Arash Asfaram, Mehrorang Ghaedi, Hamedreza Javadian, Alireza Goudarzi
A simple, rapid, and efficient method of dispersive micro solid phase extraction (D-μ-SPE) combined with UV-Vis spectrophotometry via ultrasound-assisted (UA) was applied for the determination and preconcentration of quercetin in extract of watercress (Nasturtium officinale), fruit juice and water samples. The sorbent in this method was synthesized by doping copper and sulfide into the tetragonal structure of SnO2 -nanoparticles (Cu- and S- @SnO2 -NPs) and subsequently loading it on activated carbon (AC). The D-μ-SPE parameters with direct effect on the extraction efficiency of the targeted analyte, such as sample pH, volume of eluent, sorbent mass and ultrasound time were optimized using central composite design method...
October 2018: Ultrasonics Sonochemistry
Vahideh Ghorani, Narges Marefati, Farzaneh Shakeri, Ramin Rezaee, Marzie Boskabady, Mohammad Hossein Boskabady
Antioxidant, antimicrobial, anti-hyperglycaemic, anti-diabetic and anti-inflammatory effects of Allium cepa (A. cepa) have been previously shown. In this study, the effects of A. cepa aqueous-alcoholic extract on tracheal responsiveness, lung inflammatory cells and phospholipase A2 (PLA2) level in bronchoalveolar fluid (BALF) of asthmatic rats were examined. Wistar rats were randomly divided into control group (C), asthmatic group (A), asthmatic group (A) treated with A. cepa extract (AC, 0.175, 0.35, and 0...
June 2018: Iranian Journal of Allergy, Asthma, and Immunology
Shan Liu, Zhaodi Zheng, Shuhua Ji, Tingting Liu, Yanhan Hou, Shasha Li, Guorong Li
Senescent cells display a senescence-associated secretory phenotype (SASP), which contributes to aging. Resveratrol, an activator of SIRT1, has anti-aging, anti-inflammatory, anti-oxidant, anti-free radical and other pharmacological effects. The genus of the annual fish Nothobranchius has become an emerging animal model for studying aging. However, the underlying mechanism for resveratrol to delay aging by SASP regulation has not been elucidated in vertebrates. In this study, the annual fish N. guentheri were fed with resveratrol for long-term treatment...
June 13, 2018: Fish & Shellfish Immunology
Marianne de Vasconcelos Carvalho, Sandra Lúcia Dantas de Moraes, Cleidiel Aparecido Araujo Lemos, Joel Ferreira Santiago Júnior, Belmiro Cavalcanti do Egito Vasconcelos, Eduardo Piza Pellizzer
OBJECTIVE: The aim of this systematic review was to compare outcomes between surgical and non-surgical treatment of actinic cheilitis (AC). MATERIALS AND METHODS: A systematic review and meta-analysis based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses guideline was performed. A search of PubMed/MEDLINE, Web of Science, and Cochrane Library databases was conducted. Articles were selected based on the inclusion criteria: randomized clinical trials, prospective/retrospective studies, and case series with at least 10 patients, with a minimum follow-up period of 6 months...
June 16, 2018: Oral Diseases
David E Hintenlang, Xia Jiang, Kevin J Little
PURPOSE: To document a study in shielding a high-sensitivity digital mammography system detector from AC magnetic fields of magnitudes great enough to induce imaging artifacts. METHODS/MATERIALS: Preliminary evaluation of AC magnetic fields at a site designated for a digital breast tomosynthesis (DBT) system raised concerns that the magnetic component of electromagnetic interference (EMI) may be great enough to induce imaging artifacts. Subsequent measurements using digital detector arrays from two separate manufacturers verified this concern, and AC magnetic fields were mapped, spatially and temporally, throughout the area of concern...
June 15, 2018: Journal of Applied Clinical Medical Physics
Diangeng Li, Delong Zhao, Weiguang Zhang, Qian Ma, Dong Liu, Qi Huang, Ying Zheng, Xueyuan Bai, Xuefeng Sun, Xiangmei Chen
We established a young (Y)-old (O) rat kidney transplantation model. With this model, we detected no age-related differences in renal structure between Y→Y and Y→O kidneys or O→O and O→Y kidneys. However, we did detect differences in levels of the senescence markers β-gal and p16 as well as the inflammatory cytokines TNF-α and IL-1β. Using proteomics analysis we detected 66 proteins associated with suppression of aging and 73 proteins associated with enhancement of aging. After construction of a protein-protein interaction network, a total of 73 nodes and 99 edges were analyzed using MCODE, and three significant modules were selected...
June 14, 2018: Aging
Andrei M Beliaev, Michael Booth, David Rowbotham, Colleen Bergin
BACKGROUND: The 2018 Tokyo guidelines for acute cholangitis (AC) use white cell count (WCC) as one of the diagnostic criteria. However, the 2018 Tokyo guidelines grading does not provide guidance for AC patients with normal WCC. In this situation, other inflammatory biomarkers also can be used to diagnose AC and grade severity, but their diagnostic values are yet undetermined. The aims of this study were to evaluate the discriminative powers of common inflammatory markers compared with WCC for diagnosing AC and to determine their diagnostic cutoff levels...
August 2018: Journal of Surgical Research
Aritra K Mukhopadhyay, Tianting Xie, Benno Liebchen, Peter Schmelcher
We show that the direction of directed particle transport in a two-dimensional ac-driven lattice can be dynamically reversed by changing the structure of the lattice in the direction perpendicular to the applied driving force. These structural changes introduce dimensional coupling effects, the strength of which governs the timescale of the current reversals. The underlying mechanism is based on the fact that dimensional coupling allows the particles to explore regions of phase space which are inaccessible otherwise...
May 2018: Physical Review. E
Simon C Potter, Aurélien Luciani, Sean R Eddy, Youngmi Park, Rodrigo Lopez, Robert D Finn
The HMMER webserver [] is a free-to-use service which provides fast searches against widely used sequence databases and profile hidden Markov model (HMM) libraries using the HMMER software suite ( The results of a sequence search may be summarized in a number of ways, allowing users to view and filter the significant hits by domain architecture or taxonomy. For large scale usage, we provide an application programmatic interface (API) which has been expanded in scope, such that all result presentations are available via both HTML and API...
June 14, 2018: Nucleic Acids Research
Huidan Lou, Lei Yin, Biquan Zhang, Zhong-Wen Ouyang, Bao Li, Zhenxing Wang
By utilizing the quinolinic derivative, 8-carboxymethoxy-2-carboxylicquinoline (L), five transition metal coordination complexes, [M(L)(H2 O)3 ]·H2 O] (M = Mn (1), Co (2)), [Ni(L)(H2 O)2 ] (3), and {[M(L)](H2 O)} n (M = Ni (4), Cu (5)), were synthesized by hydrothermal methods employing similar synthetic strategies. The crystal structures, magnetism and high-field EPR were characterized for the obtained compounds. 1-3 are mononuclear compounds. 1 and 2 have pentagonal bipyramidal geometry, while 4 and 5 exhibit one-dimensional zig-zag chain...
June 15, 2018: Inorganic Chemistry
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