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https://www.readbyqxmd.com/read/29475041/antrodia-cinnamomea-mycelial-fermentation-broth-inhibits-the-epithelial-mesenchymal-transition-of-human-esophageal-adenocarcinoma-cancer-cells
#1
Yu-Ming Liu, Yu-Kuo Liu, Pin-I Huang, Tung-Hu Tsai, Yu-Jen Chen
Esophageal cancer is associated with a high mortality rate and easy metastasis. The aim of this study is to investigate the effect of the bio-product Antrodia cinnamomea mycelial fermentation broth (AC-MFB) on the epithelial mesenchymal transition (EMT) of human esophageal cancer cells and the molecular mechanisms underlying these effects. Transforming growth factor β (TGF-β) was used to induce EMT in human esophageal BE3 cancer cells. Changes in cell morphology and migration potential were examined. The expression of E-cadherin, N-cadherin, vimentin, and other transcriptional factors was studied by western blot assay...
February 20, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29474530/mugan-multi-gpu-accelerated-ampliconnoise-server-for-rapid-microbial-diversity-assessment
#2
Byunghan Lee, Hyeyoung Min, Sungroh Yoon
Motivation: Metagenomic sequencing has become a crucial tool for obtaining a gene catalogue of operational taxonomic units (OTUs) in a microbial community. A typical metagenomic sequencing produces a large amount of data (often in the order of terabytes or more), and computational tools are indispensable for efficient processing. In particular, error correction in metagenomics is crucial for accurate and robust genetic cataloging of microbial communities. However, many existing error-correction tools take a prohibitively long time and often bottleneck the whole analysis pipeline...
February 20, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29474519/victree-an-automated-framework-for-taxonomic-classification-from-protein-sequences
#3
Sejal Modha, Anil Thanki, Susan F Cotmore, Andrew J Davison, Joseph Hughes
Motivation: The increasing rate of submission of genetic sequences into public databases is providing a growing resource for classifying the organisms that these sequences represent. To aid viral classification, we have developed ViCTree, which automatically integrates the relevant sets of sequences in NCBI GenBank and transforms them into an interactive maximum likelihood phylogenetic tree that can be updated automatically. ViCTree incorporates ViCTreeView, which is a JavaScript-based visualisation tool that enables the tree to be explored interactively in the context of pairwise distance data...
February 20, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29474430/evidence-for-chemical-interference-effect-of-an-allelopathic-plant-on-neighboring-plant-species-a-field-study
#4
Antonio I Arroyo, Yolanda Pueyo, M Luz Giner, Ana Foronda, Pedro Sanchez-Navarrete, Hugo Saiz, Concepción L Alados
Many studies have reported the phytotoxicity of allelopathic compounds under controlled conditions. However, more field studies are required to provide realistic evidences for the significance of allelopathic interference in natural communities. We conducted a 2-years field experiment in a semiarid plant community (NE Spain). Specifically, we planted juvenile individuals and sowed seeds of Salsola vermiculata L., Lygeum spartum L. and Artemisia herba-alba Asso. (three co-dominant species in the community) beneath adult individuals of the allelopathic shrub A...
2018: PloS One
https://www.readbyqxmd.com/read/29473980/low-dose-t1w-dce-mri-for-early-time-points-perfusion-measurement-in-patients-with-intracranial-tumors-a-pilot-study-applying-the-microsphere-model-to-measure-absolute-cerebral-blood-flow
#5
Ka-Loh Li, Daniel Lewis, Alan Jackson, Sha Zhao, Xiaoping Zhu
BACKGROUND: Previous studies have measured cerebral blood flow (CBF) with DSC-MRI using an "early time points" (ET) method based on microsphere theory. PURPOSE: To develop and assess a new ET method for absolute CBF estimation using low-dose high-temporal (LDHT) T1W-DCE-MRI. STUDY TYPE: Retrospective cohort study. SUBJECTS: Seven patients with sporadic vestibular schwannoma (VS) who underwent test-retest imaging; one patient with glioblastoma multiforme (GBM) imaged pretreatment; and 12 neurofibromatosis type 2 (NF2) patients undergoing bevacizumab treatment, imaged pre- and 90 days posttreatment...
February 23, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29473321/reliability-of-autonomic-and-vascular-components-of-baroreflex-sensitivity-in-adolescents
#6
Ricardo S Oliveira, Alan R Barker, Florian Debras, Alexandra O'Doherty, Craig A Williams
Improvements in the autonomic and vascular systems are implicated in cardiovascular disease risk reduction. Baroreflex sensitivity (BRS) is composed of vascular and autonomic components. This study aimed to investigate between- and within-day reliability of BRS and its autonomic and vascular determinants in adolescents. Thirteen male adolescents (14·1 ± 0·5 y) participated in this study. For between-day reliability, participants completed four experimental visits separated by a minimum of 48-h. For within-day reliability, participants repeated BRS assessments three times in the morning with one hour between the measures...
February 23, 2018: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29472718/pharmacologic-inhibition-of-stat5-in-acute-myeloid-leukemia
#7
Bettina Wingelhofer, Barbara Maurer, Elizabeth C Heyes, Abbarna A Cumaraswamy, Angelika Berger-Becvar, Elvin D de Araujo, Anna Orlova, Patricia Freund, Frank Ruge, Jisung Park, Gary Tin, Siawash Ahmar, Charles-Hugues Lardeau, Irina Sadovnik, Dávid Bajusz, György Miklós Keserű, Florian Grebien, Stefan Kubicek, Peter Valent, Patrick T Gunning, Richard Moriggl
The transcription factor STAT5 is an essential downstream mediator of many tyrosine kinases (TKs), particularly in hematopoietic cancers. STAT5 is activated by FLT3-ITD, which is a constitutively active TK driving the pathogenesis of acute myeloid leukemia (AML). Since STAT5 is a critical mediator of diverse malignant properties of AML cells, direct targeting of STAT5 is of significant clinical value. Here, we describe the development and preclinical evaluation of a novel, potent STAT5 SH2 domain inhibitor, AC-4-130, which can efficiently block pathological levels of STAT5 activity in AML...
February 2, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29471664/anhydrosaccharides-a-new-class-of-the-fragile-plastic-crystals
#8
Ewa Kamińska, Olga Madejczyk, Magdalena Tarnacka, Karolina Jurkiewicz, Kamila Wolnica, Wioleta Edyta Śmiszek-Lindert, Kamil Kamiński, Marian Paluch
In this paper, 1,6-anhydro-β-D-glucopyranose (anhGLU), 1,6-anhydro-β-D-mannopyranose (anhMAN), and 1,6-anhydro-β-D-galactopyranose (anhGAL), three new materials that form the Orientationally Disordered Crystal (ODIC) phase, have been thoroughly investigated using various experimental techniques. All measurements clearly indicated that these compounds possess a series of very interesting physical properties that are considerably different than those reported for ordinary plastic crystals. X-Ray diffraction investigations have revealed enormously long-range static correlations between molecules, reaching even 120 Å...
February 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29471611/update-on-bone-conduction-auditory-brainstem-responses-a-review
#9
Young Joon Seo, Chanbeom Kwak, Saea Kim, Yoon Ah Park, Kyoung Ho Park, Woojae Han
Auditory brainstem responses (ABR) have been used as a powerful and the most common objective tool to evaluate hearing sensitivity and to diagnose the types of hearing loss and neurological disorders, through the auditory peripheral pathway to a central level of the brainstem, since 1971. Although bone-conduction (BC) ABR could be an alternative to air-conduction (AC) ABR, as the former overcomes some limitations of the latter, the majority of clinicians rarely utilize it due to a lack of knowledge and no routine test administration...
February 26, 2018: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/29471299/the-effect-of-allium-cepa-extract-on-lung-oxidant-antioxidant-and-immunological-biomarkers-in-ovalbumin-sensitized-rats
#10
Narges Marefati, Naeima Eftekhar, Mahsa Kaveh, Javad Boskabadi, Farimah Beheshti, Mohammad Hossein Boskabady
OBJECTIVES: To evaluate the effects of Allium cepa (A. cepa) on levels of oxidants, antioxidants and immunological markers in the broncho-alveolar lavage fluids in sensitized rats. MATERIALS AND METHODS: Oxidant-antioxidant markers and cytokines in BALF of control rats treated with saline (group C), ovalbumin-sensitized rats (group S), rats treated with 1.25 μg/ mL dexamethasone and three doses (35, 70 and 140 mg/kg/day) of A. cepa extract (S+AC) were investigated...
February 22, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29470616/automated-spect-analysis-compared-with-expert-visual-scoring-for-the-detection-of-ffr-defined-coronary-artery-disease
#11
R S Driessen, P G Raijmakers, I Danad, W J Stuijfzand, S P Schumacher, J A Leipsic, J K Min, J Knuuti, A A Lammertsma, A C van Rossum, N van Royen, S R Underwood, P Knaapen
PURPOSE: Traditionally, interpretation of myocardial perfusion imaging (MPI) is based on visual assessment. Computer-based automated analysis might be a simple alternative obviating the need for extensive reading experience. Therefore, the aim of the present study was to compare the diagnostic performance of automated analysis with that of expert visual reading for the detection of obstructive coronary artery disease (CAD). METHODS: 206 Patients (64% men, age 58...
February 22, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29470417/ultrarapid-multimode-microwave-synthesis-of-nano-submicron-%C3%AE-sic
#12
Min Zhao, Michael Johnson, Wenzhi He, Guangming Li, Chen Zhao, Luling Yu, Juwen Huang, Haochen Zhu
This paper presents the design, development and realization of a fast and novel process for the synthesis of 3C silicon carbide (β-SiC) nanorods and submicron powder. Using SiO₂ (or Si) and activated carbon (AC), this process allows β-SiC to be synthesized with almost 100% purity in timeframes of seconds or minutes using multimode microwave rotary tube reactors under open-air conditions. The synthesis temperature used was 1460 ± 50 °C for Si + AC and 1660 ± 50 °C for SiO₂ + AC. The shortest β-SiC synthesis time achieved was about 20 s for Si + AC and 100 s for SiO₂ + AC...
February 22, 2018: Materials
https://www.readbyqxmd.com/read/29470354/poor-survival-after-retransplantation-in-nash-cirrhosis
#13
Avesh J Thuluvath, Po-Hung Chen, Paul J Thuluvath, Sergey Kantsevoy, Yulia Savva
BACKGROUND: Nonalcoholic steatohepatitis (NASH) cirrhosis is a common indication for liver transplantation (LT) in the U.S. There is a paucity of data on retransplantation (re-LT) in those who were initially transplanted for NASH. METHODS: We queried the UNOS data sets from 2002-2016 to analyze the outcomes of adults with NASH (n=128) and compared them to groups that received re-LT for cryptogenic cirrhosis (CC, n=189), alcoholic cirrhosis (AC, n=300) or autoimmune hepatitis cirrhosis (AIH-C, n=118) after excluding multiple-organ re-LT and individuals with HCC...
February 20, 2018: Transplantation
https://www.readbyqxmd.com/read/29469814/bifunctional-bamboo-like-cose2-arrays-for-high-performance-asymmetric-supercapacitor-and-electrocatalytic-oxygen-evolution
#14
Tian Chen, Songzhan Li, Pengbin Gui, Jian Wen, Xuemei Fu, Guojia Fang
Bifunctional bamboo-like CoSe2 arrays are synthesized by thermal annealing of Co(CO3)0.5OH grown on carbon cloth in Se atmosphere. The obtained CoSe2 arrays have excellent electrical conductivity, larger electrochemical active surface areas and can directly serve as a binder-free electrode for supercapacitor and oxygen evolution reaction (OER). When tested as an electrode for supercapacitor, the CoSe2 delivers a higher specific capacitance (544.6 F g-1 at current density of 1 mA cm-2) compared with CoO (308...
February 22, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29468947/rituximab-is-an-acceptable-alternative-to-ocrelizumab-for-treating-multiple-sclerosis-commentary
#15
Bruce Ac Cree
No abstract text is available yet for this article.
February 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29468868/b-site-cation-ordered-double-perovskite-oxide-as-an-outstanding-electrode-material-for-supercapacitive-energy-storage-based-on-the-anion-intercalation-mechanism
#16
Zhenye Xu, Yu Liu, Wei Zhou, Moses O Tade, Zongping Shao
Perovskite oxides are highly promising electrodes for oxygen-ion-intercalation-type supercapacitors owing to their high oxygen vacancy concentration, oxygen diffusion rate and tap density. Based on the anion intercalation mechanism, the capacitance is contributed by surface redox reactions and oxygen ion intercalation in the bulk materials. A high concentration of oxygen vacancies is needed because it is the main charge carrier. In this study, we propose B-site cation-ordered Ba2Bi0.1Sc0.2Co1.7O6-δ as an electrode material with an extremely high oxygen vacancy concentration and oxygen diffusion rate...
February 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29467030/drug-discontinuation-before-contrast-procedures-and-the-effect-on-acute-kidney-injury-and-other-clinical-outcomes-a-systematic-review-protocol
#17
Swapnil Hiremath, Jeanne Françoise Kayibanda, Benjamin J W Chow, Dean Fergusson, Greg A Knoll, Wael Shabana, Brianna Lahey, Olivia McBride, Alexandra Davis, Ayub Akbari
BACKGROUND: Contrast-induced acute kidney injury (CI-AKI) is defined as worsening of renal function after the administration of iodinated contrast material. In patients with cardiovascular disease, kidney disease, and/or diabetes, renin-angiotensin system blockers, non-steroidal anti-inflammatory drugs, diuretics, and metformin can increase the risk of CI-AKI when undergoing contrast imaging. Despite CI-AKI being the leading iatrogenic cause of acute kidney injury, there is a lack of sufficient scientific evidence supporting which drugs should be stopped, when they should be stopped, and when they should be resumed...
February 21, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29466794/foxo1-a-potential-therapeutic-target-regulates-autophagic-flux-oxidative-stress-mitochondrial-dysfunction-and-apoptosis-in-human-cholangiocarcinoma-qbc939-cells
#18
Wei He, Aiqing Zhang, Lei Qi, Chen Na, Rui Jiang, Zhining Fan, Jianping Chen
BACKGROUND/AIMS: Autophagy is an evolutionarily conserved catabolic mechanism to maintain energy homeostasis and to remove damaged cellular components, which plays an important role in the survival of various cells. Inhibiting autophagy is often applied as a new strategy to halt the growth of cancer cells. METHODS: The effect of FOXO1 gene on cellular function and apoptosis and its underlying mechanisms were investigated in cultured QBC939 cells by the methylthiazoletetrazolium (MTT) assay, western blot, DCFDA mitochondrial membrane potential, and ATP content measurement...
February 16, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29466694/lipid-pathway-deregulation-in-advanced-prostate-cancer
#19
REVIEW
Laura Galbraith, Hing Y Leung, Imran Ahmad
The link between prostate cancer (PC) development and lipid metabolism is well established, with AR intimately involved in a number of lipogenic processes involving SREBP1, PPARG, FASN, ACC, ACLY and SCD1. Recently, there is growing evidence implicating the role of obesity and peri-prostatic adipose tissue (PPAT) in PC aggressiveness and related mortality, suggesting the importance of lipid pathways in both localised and disseminated disease. A number of promising agents are in development to target the lipogenic axis in PC, and the likelihood is that these agents will form part of combination drug strategies, with targeting of multiple metabolic pathways (e...
February 18, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29466604/combined-ac-electrokinetic-effects-theoretical-considerations-on-a-three-axial-ellipsoidal-model
#20
Jan Gimsa
AC fields induce charges at the structural interfaces of particles or biological cells. The interaction of these charges with the field generates frequency-dependent forces that are the basis for AC-electrokinetic effects such as dielectrophoresis (DEP), electrorotation (ROT), and electro-orientation. The effects can be used for the manipulation or dielectric single-particle spectroscopy. The observation of a particular effect depends on the spatial and temporal field distributions, as well as on the shape and the dielectric and viscoelastic properties of the object...
February 21, 2018: Electrophoresis
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