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Vestibular System

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https://www.readbyqxmd.com/read/29342035/systematic-review-of-hearing-preservation-after-radiotherapy-for-vestibular-schwannoma
#1
Adam R Coughlin, Tyler J Willman, Samuel P Gubbels
OBJECTIVE: To determine the long-term hearing preservation rate for spontaneous vestibular schwannoma treated by primary radiotherapy. DATA SOURCES: The MEDLINE/PubMed, Web of Science, Cochrane Reviews, and EMBASE databases were searched using a comprehensive Boolean keyword search developed in conjunction with a scientific librarian. English language papers published from 2000 to 2016 were evaluated. STUDY SELECTION: Inclusion criteria: full articles, pretreatment and posttreatment audiograms or audiogram based scoring system, vestibular schwannoma only tumor type, reported time to follow-up, published after 1999, use of either Gamma Knife or linear accelerator radiotherapy...
January 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29336136/international-clinical-protocol-on-vestibular-disorders-dizziness
#2
Kostiantyn Trinus, Claus-Frenz Claussen
26-28 May at 43 Congress of Neurootological and Equilibriometric Society (Budapest, Hungary) International Clinical Protocol on Vestibular Disorders (Dizziness) being discussed and accepted as Consensus Document. Cochrane reports estimates that dizziness has prevalence of 22.9% in the last 12 months and an incidence of 3.1%. Only 1.8% of adults consulted a physician in the last 12 months. Cochrane reviews suggest that the evidence base for dizziness evaluation is weak, thus necessitates the creation of evidence-based document...
December 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/29325939/liponeurocytoma-of-the-cerebello-pontine-angle
#3
Carmela Chiaramonte, Sylvain Rabaste, Timothee Jacquesson, David Meyronet, François Cotton, Emmanuel Jouanneau, Moncef Berhouma
Liponeurocytoma is a very rare tumor classified as grade II (neuronal and mixed neuronal-glial tumors) according to 2016 WHO classification of Tumors of the Central Nervous System. The median age is 50-years-old and the most frequent location is the posterior cranial fossa especially within the cerebellar hemispheres; those arising in the cerebellopontine angle are exceptional. We herein report the clinical, radiological and pathological characteristics of a cerebellopontine angle liponeurocytoma in a 35-year-old woman...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29324510/reliability-and-validity-of-computerized-force-platform-measures-of-balance-function-in-healthy-older-adults
#4
Cathy C Harro, Chelsea Garascia
BACKGROUND AND PURPOSE: Postural control declines with aging and is an independent risk factor for falls in older adults. Objective examination of balance function is warranted to direct fall prevention strategies. Force platform (FP) systems provide quantitative measures of postural control and analysis of different aspects of balance. The purpose of this study was to examine the reliability and validity of FP measures in healthy older adults. METHODS: This study enrolled 46 healthy elderly adults, mean age 67...
January 10, 2018: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29321511/enhancing-vestibular-function-in-the-elderly-with-imperceptible-electrical-stimulation
#5
Jorge M Serrador, Brian M Deegan, Maria C Geraghty, Scott J Wood
Age-related loss of vestibular function can result in decrements in gaze stabilization and increased fall risk in the elderly. This study was designed to see if low levels of electrical stochastic noise applied transcutaneously to the vestibular system can improve a gaze stabilization reflex in young and elderly subject groups. Ocular counter-rolling (OCR) using a video-based technique was obtained in 16 subjects during low frequency passive roll tilts. Consistent with previous studies, there was a significant reduction in OCR gains in the elderly compared to the young group...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317827/optimal-management-of-cogan-s-syndrome-a-multidisciplinary-approach
#6
REVIEW
Vittorio D'Aguanno, Massimo Ralli, Marco de Vincentiis, Antonio Greco
Cogan's syndrome (CS) is a rare disorder characterized by nonsyphilitic interstitial keratitis (IK) and audio-vestibular symptoms. CS affects mainly young Caucasian adults, mostly during their first three decades of age, and may develop into typical and atypical variants. Typical CS manifests primarily with IK and hearing loss, whereas atypical CS usually presents with inflammatory ocular manifestations in association with audio-vestibular symptoms but mostly different Ménière-like symptoms and, more frequently, with systemic inflammation (70%), of which vasculitis is the pathogenic mechanism...
2018: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/29315189/self-evaluated-quality-of-life-and-functional-outcomes-after-microsurgery-stereotactic-radiation-or-observation-only-for-vestibular-schwannoma-of-the-adult-patient-a-systematic-review
#7
Efstathios Papatsoutsos, Patrick M Spielmann
OBJECTIVE: To evaluate the impact of different management options on health-related quality of life (HRQoL) in vestibular schwannoma patients. DATA SOURCES: A systematic search of the Cochrane Database, Database of Abstracts of Reviews of Effectiveness, and the Ovid Medline & EMBASE was performed. English and German language studies published between 1980 and 2015 were considered. STUDY SELECTION: This is a systematic review of HRQoL of patients managed for vestibular schwannoma...
February 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29307789/inner-ear-involvement-in-fabry-disease-clinical-and-audiometric-evaluation-of-a-large-cohort-of-patients-followed-in-a-reference-centre
#8
Jorge Rodrigues, Olga Azevedo, Nuno Sousa, Damião Cunha, Alexandre Mexedo, Rui Fonseca
BACKGROUND: Fabry disease (FD) is a lysosomal storage disorder (LSD) that involves the cochleovestibular system. Tinnitus and progressive sensorineural hearing loss are frequent complains. A stabilization of hearing function has been reported with enzyme replacement therapy (ERT). This study aims to characterize the inner ear involvement, identify factors associated to hearing loss and evaluate the effect of ERT on the hearing function of FD patients. METHODS: We reviewed the clinical records of patients with confirmed diagnosis of FD followed in a Reference Centre on LSD in the North of Portugal...
January 4, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29307127/a-case-of-canine-neurological-leishmaniasis
#9
Rosanna Zobba, Maria Antonietta Evangelisti, Maria Lucia Manunta, Alberto Alberti
In this study we describe a case of neurological leishmaniasis in a dog, reported in an endemic area, with signs of multifocal intracranial lesions involving the vestibular system and the cerebellum. Serum biochemistry revealed a decrease of albumin-globulin ratio caused by an increase of alfa2-, beta-, and gamma- globulin, while antibody titers were highly positive for Leishmania spp. Magnetic resonance images of the brain were consistent with a granulomatous in ammation/infection. Cerebrospinal uid revealed a marked mononuclear pleocytosis and was positive to the Pandy Test, as well as to a Leishmania spp...
December 29, 2017: Veterinaria Italiana
https://www.readbyqxmd.com/read/29306256/isolation-and-culture-of-adult-mouse-vestibular-nucleus-neurons
#10
Aydın Him, Serap Altuntaş, Gürkan Öztürk, Ender Erdoğan, Nureddin Cengiz
Background/aim: Isolated cell cultures are widely used to study neuronal properties due to their advantages. Although embryonic animals are preferred for culturing, their morphological or electrophysiological properties may not reflect adult neurons, which may be important in neurodegenerative diseases. This paper aims to develop a method for preparing isolated cell cultures of medial vestibular nucleus (MVN) from adult mice and describe its morphological and electrophysiological properties.Materials and methods: Vestibular nucleus neurons were mechanically and enzymatically isolated and cultured using a defined medium with known growth factors...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29304173/the-reliability-of-nonlinear-least-squares-algorithm-for-data-analysis-of-neural-response-activity-during-sinusoidal-rotational-stimulation-in-semicircular-canal-neurons
#11
Pengyu Ren, Bowen Li, Shiyao Dong, Lin Chen, Yuelin Zhang
Although many mathematical methods were used to analyze the neural activity under sinusoidal stimulation within linear response range in vestibular system, the reliabilities of these methods are still not reported, especially in nonlinear response range. Here we chose nonlinear least-squares algorithm (NLSA) with sinusoidal model to analyze the neural response of semicircular canal neurons (SCNs) during sinusoidal rotational stimulation (SRS) over a nonlinear response range. Our aim was to acquire a reliable mathematical method for data analysis under SRS in vestibular system...
2018: PloS One
https://www.readbyqxmd.com/read/29298819/reduction-of-motion-sickness-through-targeting-histamine-n-methyltransferase-in-the-dorsal-vagal-complex-of-the-brain
#12
Miao-Miao Chen, Li-Hua Xu, Li Chang, Peng Yin, Zheng-Lin Jiang
To investigate the role of histamine N-methyltransferase (HNMT) activity in the development of motion sickness (MS) in the dorsal vagal complex (DVC) to inform the development of new drugs for MS, Beagle dogs and Sprague-Dawley rats were rotated to simulate MS. HNMT expression in the brain stem and DVC was measured. The effects of systemic application of tacrine, a HNMT inhibitor, on the development of MS were observed. Moreover, we microinjected a histamine receptor H1 inhibitor, promethazine, into the DVC to verify the involvement of histaminergic neurotransmission in MS...
January 3, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29298650/potential-application-of-centrifuges-to-protect-the-cns-in-space-and-on-earth
#13
Yoshiki Takamatsu, Gilbert Ho, Yuki Shimizu, Shuei Sugama, Takato Takenouchi, Masaaki Waragai, Jianshe Wei, Makoto Hashimoto
BACKGROUND: Centrifuges are the principal means of generating physiological hypergravity and have been used for many medical purposes, including the therapy of psychiatric diseases and evaluation of vestibular system in the pilots. In particular, modern centrifuges have evolved into mechanically sophisticated precision instruments compared to primitive ones in old times, indicating that centrifuges might possess great potential in modern medicine. Indeed, studies are in progress to apply centrifuges to musculoskeletal degenerative diseases, such as osteoporosis and sarcopenia...
December 29, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29288435/balance-training-does-not-alter-reliance-on-visual-information-during-static-stance-in-those-with-chronic-ankle-instability-a-systematic-review-with-meta-analysis
#14
REVIEW
Kyeongtak Song, Evan Rhodes, Erik A Wikstrom
BACKGROUND: Visual, vestibular, and somatosensory systems contribute to postural control. Chronic ankle instability (CAI) patients have been observed to have a reduced ability to dynamically shift their reliance among sources of sensory information and rely more heavily on visual information during a single-limb stance relative to uninjured controls. Balance training is proven to improve postural control but there is a lack of evidence regarding the ability of balance training programs to alter the reliance on visual information in CAI patients...
December 29, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29283095/evaluation-of-cervical-vestibular-evoked-myogenic-potential-in-subjects-with-chronic-noise-exposure
#15
Nehal Mamdouh Abd El Salam, Elshahat Ibrahem Ismail, Ayman El Saeed El Sharabasy
OBJECTIVE: Noise has been recognized as a major cause of cochlear damage resulting in both tinnitus and hearing loss. On the other hand, damage to the vestibular system, especially the saccule, can be considered as a potential problem. The cervical vestibular-evoked myogenic potentials (cVEMPs) have been established as a clinical test of measuring both sac-cular and inferior vestibular nerve function. Therefore, it is thought to be sensitive to the noise-induced damage to the vestibular system...
December 14, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29277248/communication-pathways-to-and-from-the-inner-ear-and-their-contributions-to-drug-delivery
#16
REVIEW
Alec N Salt, Keiko Hirose
The environment of the inner ear is highly regulated in a manner that some solutes are permitted to enter while others are excluded or transported out. Drug therapies targeting the sensory and supporting cells of the auditory and vestibular systems require the agent to gain entry to the fluid spaces of the inner ear, perilymph or endolymph, which surround the sensory organs. Access to the inner ear fluids from the vasculature is limited by the blood-labyrinth barriers, which include the blood-perilymph and blood-strial barriers...
December 19, 2017: Hearing Research
https://www.readbyqxmd.com/read/29258928/predictive-value-of-intraoperative-facial-motor-evoked-potentials-in-vestibular-schwannoma-surgery-under-two-anesthesia-protocols
#17
Miao Ling, Xiaorong Tao, Siyuan Ma, Xiaocui Yang, Li Liu, Xing Fan, Guijun Jia, Hui Qiao
OBJECTIVE: To validate the feasibility of facial motor evoked potential (FMEP) in facial nerve (FN) monitoring during vestibular schwannoma (VS) surgery under two anesthesia protocols, and to examine its value for postoperative prognosis. METHODS: This prospective study included 106 patients with VS, who underwent microsurgical excision between May 2014 and November 2016 at the Beijing Tiantan Hospital, Capital Medical University, China. All patients were investigated for FMEP elicited by transcranial electrical stimulation in the contralateral facial motor cortex...
December 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29239806/development-of-postural-control-and-maturation-of-sensory-systems-in-children-of-different-ages-a-cross-sectional-study
#18
Cristina Dos Santos Cardoso de Sá, Catarina Costa Boffino, Renato Teodoro Ramos, Clarice Tanaka
OBJECTIVE: To evaluate the stability, postural adjustments and contributions of sensory information for postural control in children. METHODS: 40 boys and 40 girls were equally divided into groups of 5, 7, 9 and 12 years (G5, G7, G9 and G12). All children were submitted to dynamic posturography using a modified sensory organization test, using four sensory conditions: combining stable or sway referencing platform with eyes opened, or closed. The area and displacements of the center of pressure were used to determine stability, while the adjustments were used to measure the speed of the center of pressure displacements...
November 8, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/29238670/specific-organ-targeted-vestibular-physiotherapy-the-pivot-in-the-contemporary-management-of-vertigo-and-imbalance
#19
EDITORIAL
Anirban Biswas, Bibhas Barui
Introduction: Advancements in our understanding of vestibular physiology and how it is changes in different diseases have established that of the three therapeutic approaches to treat disorders of the vestibular system viz. pharmacotherapy, surgery and physical therapy, it is the later i.e., physical therapy which is the most efficacious modality in the management of balance disorders. The futility of vestibular sedatives in the correction of vestibular disorders and in the restoration of balance and the very limited role of surgery has now been recognised...
December 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29234301/balance-screening-of-vestibular-function-in-subjects-aged-4-years-and-older-a-living-laboratory-experience
#20
María Carolina Bermúdez Rey, Torin K Clark, Daniel M Merfeld
To better understand the various individual factors that contribute to balance and the relation to fall risk, we performed the modified Romberg Test of Standing Balance on Firm and Compliant Support, with 1,174 participants between 4 and 83 years of age. This research was conducted in the Living Laboratory® at the Museum of Science, Boston. We specifically focus on balance test condition 4, in which individuals stand on memory foam with eyes closed, and must rely on their vestibular system; therefore, performance in this balance test condition provides a proxy for vestibular function...
2017: Frontiers in Neurology
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