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https://www.readbyqxmd.com/read/29471475/assessing-viral-transfer-during-doffing-of-ebola-level-personal-protective-equipment-in-a-biocontainment-unit
#1
Lisa M Casanova, Kimberly Erukunuakpor, Colleen S Kraft, Joel M Mumma, Francis T Durso, Ashley N Ferguson, Christina L Gipson, Victoria L Walsh, Craig Zimring, Jennifer DuBose, Jesse T Jacob
Background: Personal protective equipment (PPE) protects healthcare workers (HCWs) caring for patients with Ebola virus disease (EVD), and PPE doffing is a critical point for preventing viral self-contamination. We assessed contamination of skin, gloves, and scrubs after doffing Ebola-level PPE contaminated with surrogate viruses: bacteriophages MS2 and Φ6. Methods: In a medical biocontainment unit, HCWs (n = 10) experienced in EVD care donned and doffed PPE following unit protocols that incorporate trained observer guidance and alcohol-based hand rub (ABHR)...
February 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29471368/human-factors-risk-analyses-of-a-doffing-protocol-for-ebola-level-personal-protective-equipment-mapping-errors-to-contamination
#2
Joel M Mumma, Francis T Durso, Ashley N Ferguson, Christina L Gipson, Lisa Casanova, Kimberly Erukunuakpor, Colleen S Kraft, Victoria L Walsh, Craig Zimring, Jennifer DuBose, Jesse T Jacob
Background: Doffing protocols for personal protective equipment (PPE) are critical for keeping healthcare workers (HCWs) safe during care of patients with Ebola virus disease. We assessed the relationship between errors and self-contamination during doffing. Methods: Eleven HCWs experienced with doffing Ebola-level PPE participated in simulations in which HCWs donned PPE marked with surrogate viruses (ɸ6 and MS2), completed a clinical task, and were assessed for contamination after doffing...
February 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29465247/viability-of-single-balloon-enteroscopy-performed-under-endoscopist-directed-sedation
#3
Leopoldo López Rosés, Beatriz Álvarez, Abel González Ramírez, Alina López Baz, Alexia Fernández López, Sara Alonso, Andrés Dacal, Eva Martí, Gino Albines, Julieta Fernández Molina, Ángel Lancho
INTRODUCTION: there is a lot of controversy with regard to who should be responsible for sedation during digestive endoscopy, particularly in advanced procedures that require deep sedation such as enteroscopy. The aim of this study was to evaluate the endoscopist-directed sedation viability during single balloon enteroscopy. MATERIAL AND METHOD: this was a prospective, observational study of a series of consecutive enteroscopies. The clinical staff included an endoscopist, scrub nurse and a nurse in charge of monitoring and sedative administration...
February 21, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29462266/effects-of-rifampin-and-doxycycline-treatments-in-patients-with-uncomplicated-scrub-typhus-an-open-label-randomized-controlled-trial
#4
Yun Sung Kim, Dong-Min Kim, Na-Ra Yoon, Mi-Sun Jang, Choon-Mee Kim
Background: Doxycycline is currently the most frequently used treatment in patients with scrub typhus, but doxycycline-resistant strains have been found, necessitating the development of a new treatment. Rifampin is known to be effective even for such strains. Thus, this study aimed to compare the effects of rifampin and doxycycline treatment in patients with scrub typhus in areas in which resistance to doxycycline has not been reported. Methods: Patients admitted to Chosun University Hospital and regional network hospitals between 2007 and 2009 with a body temperature of 37...
February 15, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29460869/scrub-typhus-in-mizoram-india
#5
H Lalrinkima, R Lalremruata, C Lalchhandama, Lalthansanga Khiangte, Freddy H Siamthara, C Lalnunpuia, S K Borthakur, Gautam Patra
No abstract text is available yet for this article.
October 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/29460860/aetiology-of-acute-encephalitis-syndrome-in-uttar-pradesh-india-from-2014-to-2016
#6
Parul Jain, Shantanu Prakash, Danish N Khan, Ravindra Kumar Garg, Rashmi Kumar, Amit Bhagat, V Ramakrishna, Amita Jain
Background & objectives: It is imperative to know the aetiology of acute encephalitis syndrome (AES) for patient management and policy making. The present study was carried out to determine the prevalence of common aetiological agents of AES in Uttar Pradesh (UP) state of India. Methods: Serum and/or CSF samples were collected from AES patients admitted at Gandhi Memorial and Associated Hospital, King George's Medical University, Lucknow, a tertiary care centre, UP during 2014-16...
October 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/29449793/clinical-proteomic-analysis-of-scrub-typhus-infection
#7
Edmond Changkyun Park, Sang-Yeop Lee, Sung Ho Yun, Chi-Won Choi, Hayoung Lee, Hyun Seok Song, Sangmi Jun, Gun-Hwa Kim, Chang-Seop Lee, Seung Il Kim
Background: Scrub typhus is an acute and febrile infectious disease caused by the Gram-negative α-proteobacterium Orientia tsutsugamushi from the family Rickettsiaceae that is widely distributed in Northern, Southern and Eastern Asia. In the present study, we analysed the serum proteome of scrub typhus patients to investigate specific clinical protein patterns in an attempt to explain pathophysiology and discover potential biomarkers of infection. Methods: Serum samples were collected from three patients (before and after treatment with antibiotics) and three healthy subjects...
2018: Clinical Proteomics
https://www.readbyqxmd.com/read/29445718/designing-and-developing-automatic-trolley-for-washing-and-dressing-the-wounds
#8
M S Golvardi Yazdi, M Naderizadeh, R Afzalipour, H A Abedi, M Radmehr, R Golvardi Yazdi, Sh Salari Pashaghi
Introduction: Many items are needed for dressing including sterile dressing set, antiseptic and washing solutions, leucoplast tape, waste bin for infectious garbage, waste bin for noninfectious garbage, safe disposal trash for sharp cutting instruments, bedpan and sometimes drugs. All the items are laid out on a simple wheeled trolley. The multiplicity of items together with problems in placing tools on trolley, forgetting some items, disturbing sterile condition, falling and damaging equipment and the need for at least two people for each procedure, all are the reasons to design and develop Automatic Trolley for Washing and Dressing the Wounds...
December 2017: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/29431689/dysregulated-th1-immune-and-vascular-responses-in-scrub-typhus-pathogenesis
#9
REVIEW
Lynn Soong
Scrub typhus is an emerging, insect-transmitted disease caused by Orientia tsutsugamushi, a Gram- and LPS-negative bacterium that replicates freely within professional phagocytes and endothelial cells. Scrub typhus is prevalent with high mortality rates, but information regarding its molecular pathogenesis, microbial virulence determinants, and key immune responses is limited. Improved animal models have recently been developed that respectively resemble the pathological features of self-limiting or severe scrub typhus in humans...
February 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29430404/spectrum-of-cardiac-manifestations-and-its-relationship-to-outcomes-in-patients-admitted-with-scrub-typhus-infection
#10
Gunasekaran Karthik, Thomas Isaiah Sudarsan, John Victor Peter, Thambu Sudarsanam, George M Varghese, Paul Kundavaram, Sowmya Sathyendra, Ramya Iyyadurai, Kishore Pichamuthu
AIM: To study the spectrum of cardiac manifestations in scrub typhus infection and assess its relationship to outcomes. METHODS: Demographic data, electrocardiographic (ECG) changes, left ventricular (LV) systolic and diastolic function, myocardial injury (defined as troponin T > 14 pg/mL), and pericardial effusion were documented. Myocarditis was diagnosed when myocardial injury was associated with global LV systolic dysfunction. The relationship between myocarditis and outcomes was assessed using logistic regression analysis and expressed as odds ratio (OR) with 95%CI...
February 4, 2018: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29429641/influence-of-the-seasonal-variation-of-environmental-conditions-on-biogas-upgrading-in-an-outdoors-pilot-scale-high-rate-algal-pond
#11
David Marín, Esther Posadas, Patricia Cano, Víctor Pérez, Raquel Lebrero, Raúl Muñoz
The influence of the daily and seasonal variations of environmental conditions on the quality of the upgraded biogas was evaluated in an outdoors pilot scale high rate algal pond (HRAP) interconnected to an external absorption column (AC) via a conical settler. The high alkalinity in the cultivation broth resulted in a constant biomethane composition during the day regardless of the monitored month, while the high algal-bacterial activity during spring and summer boosted a superior biomethane quality. CO2 concentrations in the upgraded biogas ranged from 0...
February 2, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29406814/a-randomized-controlled-trial-of-video-education-versus-skill-demonstration-which-is-more-effective-in-teaching-sterile-surgical-technique
#12
Stephanie N Pilieci, Saad Y Salim, Daithi S Heffernan, Kamal M F Itani, Rachel G Khadaroo
BACKGROUND: Video education has many advantages over traditional education including efficiency, convenience, and individualized learning. Learning sterile surgical technique (SST) is imperative for medical students, because proper technique helps prevent surgical site infections (SSIs). We hypothesize that video education is at least as effective as traditional skill demonstration in teaching first-year medical students SST. METHODS: A video series was created to demonstrate SST ( https://www...
February 6, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29405137/spectrum-of-infections-in-acute-febrile-illness-in-central-india
#13
Yogendra Pandurang Shelke, Vijayshri Suresh Deotale, Deepashri Laxmanrao Maraskolhe
INTRODUCTION: Infectious agent when enters in the host results in febrile illness. This may lead to increase in morbidity or even mortality in undiagnosed/untreated cases. There are many aetiological agents which lead to acute febrile illness. Among these aetiological agents, important is bacterial or viral aetiology. OBJECTIVE: The objective of this study is: (i) To know the aetiological agents responsible for acute undifferentiated febrile illness (AUFI) by serological test or by bacterial culture and (ii) To know the clinical profile of AUFI...
October 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29397018/from-somda-to-application-integration-strategies-in-the-or-net-demonstration-sites
#14
Max Rockstroh, Stefan Franke, Raluca Dees, Angela Merzweiler, Gerd Schneider, Max Dingler, Christian Dietz, Jonas Pfeifer, Franziska Kühn, Malte Schmitz, Alexander Mildner, Armin Janß, Jasmin Dell'Anna Pudlik, Marcus Köny, Björn Andersen, Björn Bergh, Thomas Neumuth
The effective development and dissemination of the open integration for the next generation of operating rooms require a comprehensive testing environment. In this paper, we present the various challenges to be addressed in demonstration applications, and we discuss the implementation approach, the foci of the demonstration sites and the evaluation efforts. Overall, the demonstrator setups have proven the feasibility of the service-oriented medical device architecture (SOMDA) and real-time approaches with a large variety of example applications...
February 3, 2018: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/29396933/comparison-of-scrub-typhus-meningitis-with-acute-bacterial-meningitis-and-tuberculous-meningitis
#15
Svas Raju Kakarlapudi, Anila Chacko, Prasanna Samuel, Valsan Philip Verghese, Winsley Rose
OBJECTIVE: To compare scrub typhus meningitis with bacterial and tuberculous meningitis. METHODS: Children aged <15 years admitted with meningitis were screened and those who fit criteria for diagnosis of scrub typhus meningitis (n=48), bacterial meningitis (n=44) and tuberculous meningitis (n=31) were included for analysis. Clinical features, investigations and outcomes were compared between the three types of meningitis. RESULTS: Mean age, duration of fever at presentation, presence of headache and, altered sensorium and presence of hepatomegaly/splenomegaly were statistically significantly different between the groups...
January 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29396931/scrub-typhus-meningitis-versus-acute-bacterial-meningitis-and-tuberculous-meningitis
#16
Stalin Viswanathan
No abstract text is available yet for this article.
January 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29386235/an-update-on-host-pathogen-interplay-and-modulation-of-immune-responses-during-orientia-tsutsugamushi-infection
#17
REVIEW
Fabián E Díaz, Katia Abarca, Alexis M Kalergis
The obligate intracellular bacterium Orientia tsutsugamushi is the causative agent of scrub typhus in humans, a serious mite-borne disease present in a widespread area of endemicity, which affects an estimated 1 million people every year. This disease may exhibit a broad range of presentations, ranging from asymptomatic to fatal conditions, with the latter being due to disseminated endothelial infection and organ injury. Unique characteristics of the biology and host-pathogen interactions of O. tsutsugamushi , including the high antigenic diversity among strains and the highly variable, short-lived memory responses developed by the host, underlie difficulties faced in the pursuit of an effective vaccine, which is an imperative need...
April 2018: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/29385256/implementing-a-cardiac-skills-orientation-and-simulation-program
#18
Maureen W Hemingway, Patrice Osgood, Mildred Mannion
Patients with cardiac morbidities admitted for cardiac surgical procedures require perioperative nurses with a high level of complex nursing skills. Orienting new cardiac team members takes commitment and perseverance in light of variable staffing levels, high-acuity patient populations, an active cardiac surgical schedule, and the unpredictability of scheduling patients undergoing cardiac transplantation. At an academic medical center in Boston, these issues presented opportunities to orient new staff members to the scrub person role, but hampered efforts to provide active learning opportunities in a safe environment...
February 2018: AORN Journal
https://www.readbyqxmd.com/read/29374896/-epidemiology-of-scrub-typhus-and-influencing-factors-in-yunnan-province-2006-2013
#19
Y Sun, C Shi, X L Li, L Q Fang, W C Cao
Objective: To understand the epidemiological characteristics of scrub typhus and influencing factors in Yunnan province, and provide further information for the prevention and control of scrub typhus. Methods: Based on the incidence data of scrub typhus reported in Yunnan from 2006 to 2013, the epidemiological characteristics of scrub typhus were analyzed and related environmental factors were identified with panel negative binomial regression model. Results: A total of 8 980 scrub typhus cases were reported during 2006-2013 in Yunnan...
January 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29370684/epidemiologic-characteristics-of-scrub-typhus-on-jeju-island
#20
Jong-Myon Bae
No abstract text is available yet for this article.
December 26, 2017: Epidemiology and Health
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