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https://www.readbyqxmd.com/read/28222556/is-there-influence-of-the-load-addition-during-treadmill-training-on-cardiovascular-parameters-and-gait-performance-in-patients-with-stroke-a-randomized-clinical-trial
#1
Tatiana Souza Ribeiro, Tállyta Camila Chaves da Silva, Renata Carlos Felipe, Emília Márcia Gomes de Souza E Silva, Matheus Oliveira Lacerda, Ana Paula Spaniol, Ana Raquel Rodrigues Lindquist
BACKGROUND: Although exercises involving both lower limbs are indicated for aerobic training, stroke patients have shown expressive asymmetry between the paretic and non-paretic lower limb (NPLL). Performing activities that stimulate the paretic limb during aerobic exercise may optimize training results. OBJECTIVE: To evaluate if there is influence of load addition on NPLL during treadmill training on cardiovascular parameters and gait performance of subacute stroke patients...
February 8, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28222555/effects-of-scapulohumeral-rehabilitation-protocol-on-trunk-control-recovery-in%C3%A2-patients-with-subacute-stroke-a%C3%A2-pilot%C3%A2-randomized-controlled-trial
#2
Dell'Uomo Daniela, Morone Giovanni, Centrella Antonio, Paolucci Stefano, Caltagirone Carlo, Grasso Maria Grazia, Traballesi Marco, Iosa Marco
BACKGROUND: Despite upper limb rehabilitation is widely investigated in patients with stroke, the effects of rehabilitation of scapulohumeral on trunk stabillization are mainly unknown. OBJECTIVE: To test the effects of scapulohumeral rehabilitation protocol on trunk control recovery in patients with subacute stroke. METHODS: A pilot randomized controlled trial with two groups of 14 patients each one performing 20 minutes per day, 5 days a week, for 6 weeks in add on to standard therapy...
February 8, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28222554/a-single-group-pretest-posttest-clinical-trial-for-the-effects-of-dry-needling-on-wrist-flexors-spasticity-after-stroke
#3
Noureddin Nakhostin Ansari
BACKGROUND: Spasticity is a common complication after stroke. Dry needling (DN) is suggested as a novel method for treatment of muscle spasticity. OBJECTIVE: To explore the effects of DN on wrist flexors spasticity poststroke. METHODS: A single group, pretest-posttest clinical trial was used. Twenty nine patients with stroke (16 male; mean age 54.3 years) were tested at baseline (T0), immediately after DN (T1), and one hour after DN (T2). DN was applied for flexor carpi radialis (FCR) and flexor carpi ulnaris on the affected arm for single session, one minute per muscle...
February 8, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28222549/gait-and-balance-deterioration-over-a-12-month-period-in-multiple-sclerosis-patients-with-edss-scores-%C3%A2-3-0
#4
Mary P Galea, L Eduardo Cofré Lizama, Helmut Butzkueven, Trevor J Kilpatrick
BACKGROUND AND PURPOSE: It is not currently known whether gait and balance measures are responsive to deterioration of motor function in multiple sclerosis (MS) patients with low EDSS scores (≤3.0). The aim of this study was to quantify MS-related gait and balance deterioration over a 12-month period. METHODS: Thirty-eight participants with MS (33 female, mean age: 41.1 ± 8.3 years), mean time since diagnosis 2.2 ± 4.1 years, EDSS score ≤3.0 and without clinical evidence of gait deterioration, were recruited...
February 6, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28222546/recovering-functional-independence-after-a-stroke-through-modified-constraint-induced-therapy
#5
A Doussoulin, M Arancibia, J Saiz, A Silva, M Luengo
BACKGROUND: Population ageing and changes in the epidemiological profile of neurological pathologies has resulted in an increase in patients with disabilities. Rehabilitation strategies such as Modified Constraint-Induced Movement Therapy (CIMTm) play a key role in treating patients with neurologic deficiencies and motor impairments. This intervention is intended to mitigate disability, promote maximum functional independence, and optimize social and economic participation of patients with upper extremity weakness...
January 31, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28222541/augmented-effects-of-emg-biofeedback-interfaced-with-virtual-reality-on-neuromuscular-control-and-movement-coordination-during-reaching-in-children-with-cerebral-palsy
#6
Ji Won Yoo, Dong Ryul Lee, Young Joo Cha, Sung Hyun You
BACKGROUND: The purpose of the present study was to compare therapeutic effects of an electromyography (EMG) biofeedback augmented by virtual reality (VR) and EMG biofeedback alone on the triceps and biceps (T:B) muscle activity imbalance and elbow joint movement coordination during a reaching motor taskOBJECTIVE: To compare therapeutic effects of an electromyography (EMG) biofeedback augmented by virtual reality (VR) and EMG biofeedback alone on the triceps and biceps muscle activity imbalance and elbow joint movement coordination during a reaching motor task in normal children and children with spastic cerebral palsy (CP)...
January 30, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28222539/technologies-assessing-limb-bradykinesia-in-parkinson-s-disease
#7
Hasan Hasan, Dilan S Athauda, Thomas Foltynie, Alastair J Noyce
BACKGROUND: The MDS-UPDRS (Movement Disorders Society - Unified Parkinson's Disease Rating Scale) is the most widely used scale for rating impairment in PD. Subscores measuring bradykinesia have low reliability that can be subject to rater variability. Novel technological tools can be used to overcome such issues. OBJECTIVE: To systematically explore and describe the available technologies for measuring limb bradykinesia in PD that were published between 2006 and 2016...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28222511/evaluation-of-a-dna-a%C3%AE-42-vaccine-in-aged-nzw-rabbits-antibody-kinetics-and-immune-profile-after-intradermal-immunization-with-full-length-dna-a%C3%AE-42-trimer
#8
Doris Lambracht-Washington, Min Fu, Mary Wight-Carter, Matthew Riegel, Roger N Rosenberg
A pathological hallmark of Alzheimer's disease (AD) are amyloid plaques in the brain consisting of aggregated amyloid-β 42 peptide (Aβ42) derived from cellular amyloid-β protein precursor (AβPP). Based on successful experiments in mouse AD models, active immunization with Aβ42 peptide and passive immunizations with anti-Aβ42 antibodies were started in clinical trials. Active Aβ42 peptide immunization in humans had led to an inflammatory autoimmune response, and the trial was stopped. Passive immunizations had shown some effects in slowing AD pathology...
February 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28222477/checklists-for-the-assessment-of-correct-inhalation-therapy
#9
V Knipel, S Schwarz, F S Magnet, J H Storre, C P Criée, W Windisch
Introduction For the long-term treatment of obstructive lung diseases inhalation therapy with drugs being delivered directly to the lungs as an aerosol has become the method of choice. However, patient-related mistakes in inhalation techniques are frequent and recognized to be associated with reduced disease control. Since the assessment of patient-mistakes in inhalation has yet not been standardized, the present study was aimed at developing checklists for the assessment of correct inhalation. Methods Checklists were developed in German by an expert panel of pneumologists and professionally translated into English following back-translation procedures...
February 2017: Pneumologie
https://www.readbyqxmd.com/read/28222465/autologous-conditioned-plasma-versus-placebo-injection-therapy-in-lateral-epicondylitis-of-the-elbow-a-double-blind-randomized-study
#10
Volker Schöffl, Wolfgang Willauschus, Felix Sauer, Thomas Küpper, Isabelle Schöffl, Christoph Lutter, Kolja Gelse, Jörg Dickschas
Introduction There are various therapeutic approaches to the treatment of lateral epicondylitis, a highly prevalent musculoskeletal disorder. Recently, injection therapy with autologous conditioned plasma (ACP) has shown promise as a new approach. Methods Set up as a prospective, double-blind, randomized controlled clinical trial, this study involved 50 patients with lateral epicondylitis. Following external randomization, 25 patients received one round of injection therapy with ACP (platelet rich plasma, PRP), while the remaining 25 patients received a placebo of 0...
February 21, 2017: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/28222446/the-timing-of-embryo-transfer-catheter-removal-should-it-be-delayed-or-done-immediately-a-prospective-randomized-trial
#11
Belgin Devranoğlu, Özkan Özdamar, Yiğit Çakıroğlu, Mehmet Küçükbaş, Meryem K Eken, Emek Doğer
BACKGROUND/AIMS: Data on the timing of catheter removal technique following embryo transfer (ET) are quite limited. We aimed to compare the reproductive outcomes of intracytoplasmic sperm injection (ICSI)/ET cycles in which the transfer catheter was removed immediately with those in which the catheter was removed after a delay period and hereby to evaluate the impact that the time interval before removal of the catheter following embryo deposit may have on the fertility outcomes. METHODS: A prospective randomized study was designed...
February 22, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28222379/increased-static-and-decreased-capacity-oxidation-reduction-potentials-in-plasma-are-predictive-of-metabolic-syndrome
#12
Gerd Bobe, Tora J Cobb, Scott W Leonard, Savinda Aponso, Christopher B Bahro, Dipankar Koley, Eunice Mah, Richard S Bruno, Maret G Traber
Electric conductivity in plasma is the balance between oxidized and reduced molecules (static Oxidation-Reduction Potential, sORP) and the amount of readily oxidizable molecules (capacity ORP, cORP). Adults with metabolic syndrome (MetS) have increased inflammation, dyslipidemia and oxidative stress; therefore, participants with MetS were hypothesized to have higher plasma sORP and lower cORP than those measures in healthy adults. Heparin-anticoagulated plasma from healthy and age- and gender-matched individuals with MetS (BMI: 22...
February 14, 2017: Redox Biology
https://www.readbyqxmd.com/read/28222370/increased-postural-sway-in-persons-with-multiple-sclerosis-during-short-term-exposure-to-warm-ambient-temperatures
#13
Paula Y S Poh, Amy N Adams, Mu Huang, Dustin R Allen, Scott L Davis, Anna S Tseng, Craig G Crandall
BACKGROUND: Multiple sclerosis (MS) is a neurological disease marked by demyelination and axonal loss. Individuals with MS experience increases in clinical signs and symptoms during heat exposure. OBJECTIVE: To test the hypothesis that moderate heat exposure adversely affects postural sway in individuals with MS. METHODS: Ten individuals with relapsing-remitting MS (50±8y) and nine controls (47±10y) were examined under a Thermal and a Time Control trial...
February 8, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28222360/maintenance-therapy-with-second-generation-antipsychotics-for-bipolar-disorder-a-systematic-review-and-meta-analysis
#14
REVIEW
Leif Lindström, Eva Lindström, Mikael Nilsson, Malin Höistad
BACKGROUND: Second generations antipsychotics (SGA) are frequently used for maintenance treatment in bipolar disorder. We systematically reviewed the efficacy and long-term effects of treatment with SGA, regardless of treatment strategy (SGA administered either as monotherapy or as adjunctive therapy), in comparison to placebo, lithium or valproate. Primary outcomes were relapses (mood episode recurrence) and discontinuation. METHOD: Clinical studies were identified through database searching in PubMed, Embase, PsychInfo and Cochrane Library and critically appraised based on the Cochrane Handbook...
February 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28222251/prognostic-methylation-markers-for-overall-survival-in-cytogenetically-normal-patients-with-acute-myeloid-leukemia-treated-on-swog-trials
#15
Xiaoyu Qu, Megan Othus, Jerry Davison, Yu Wu, Liying Yan, Soheil Meshinchi, Fabiana Ostronoff, Elihu H Estey, Jerry P Radich, Harry P Erba, Frederick R Appelbaum, Min Fang
BACKGROUND: Aberrant DNA methylation is known to occur in patients with acute myeloid leukemia (AML), whereas methylation signatures and prognostic markers have been proposed. The objective of the current study was to evaluate all CpG sites of the genome and identify prognostic methylation markers for overall survival in patients with AML with normal karyotype (AML-NK). METHODS: AML-NK samples from 7 SWOG trials were analyzed using a novel genome-wide approach called "CHARMcox" (comprehensive high-throughput array-based relative methylation analysis combined with the Cox proportional hazards model) controlling for known clinical covariates...
February 21, 2017: Cancer
https://www.readbyqxmd.com/read/28222250/long-term-treatment-of-cancer-associated-thrombosis-the-choice-of-the-optimal-anticoagulant
#16
REVIEW
I Elalamy, I Mahé, W Ageno, G Meyer
Patients with cancer associated thrombosis (CAT) carry a higher risk of recurrence, bleeding and mortality as compared to non-cancer patients. The specific profile of cancer patients combining frequent co-morbidities, the use of anti-tumoral therapies and the cancer progression itself represent a major therapeutic challenge for choosing a long-term anticoagulant treatment. This review discusses the practical basis of that choice among available drugs for the long-term antithrombotic strategy linked to their pharmacology, mechanism of action, evidence of clinical benefits, advantages and limitations in such a complex clinical context...
February 21, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28222220/meaningful-endpoints-for-therapies-approved-for-hematologic-malignancies
#17
B Douglas Smith, Amy E DeZern, Alex W Bastian, Brian G M Durie
BACKGROUND: Overall survival (OS) is considered the gold standard for determining treatment efficacy in oncology trials, but the relation between treatment and OS can be challenging to assess because of long study durations and the impact of subsequent therapies on outcome. Using OS can be particularly difficult for new therapies in hematologic malignancies (HMs). METHODS: This retrospective analysis was conducted to characterize the primary endpoints used to support US Food and Drug Administration (FDA) approvals for new drug or novel HM indications between January 2002 and July 2015...
February 21, 2017: Cancer
https://www.readbyqxmd.com/read/28222165/stress-increases-the-risk-of-type-2-diabetes-onset-in-women-a-12-year-longitudinal-study-using-causal-modelling
#18
Melissa L Harris, Christopher Oldmeadow, Alexis Hure, Judy Luu, Deborah Loxton, John Attia
BACKGROUND: Type 2 diabetes is associated with significant morbidity and mortality. Modifiable risk factors have been found to contribute up to 60% of type 2 diabetes risk. However, type 2 diabetes continues to rise despite implementation of interventions based on traditional risk factors. There is a clear need to identify additional risk factors for chronic disease prevention. The aim of this study was to examine the relationship between perceived stress and type 2 diabetes onset, and partition the estimates into direct and indirect effects...
2017: PloS One
https://www.readbyqxmd.com/read/28222149/ultrasonographic-evaluation-of-urinary-tract-morbidity-in-school-aged-and-preschool-aged-children-infected-with-schistosoma-haematobium-and-its-evolution-after-praziquantel-treatment-a-randomized-controlled-trial
#19
Beatrice Barda, Jean T Coulibaly, Christoph Hatz, Jennifer Keiser
BACKGROUND: Schistosoma haematobium infections are responsible for significant urinary tract (UT) complications. Schistosomiasis control programs aim to reduce morbidity, yet the extent of morbidity in preschool-aged children and the impact of treatment on morbidity reduction are not well studied. METHODOLOGY: Our study was embedded in a randomized, placebo-controlled, single-blind trial in Côte d'Ivoire, which evaluated the efficacy and safety of three doses (20, 40 and 60 mg/kg) of praziquantel in school-aged (SAC) and preschool-aged (PSAC) children infected with S...
February 21, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28222145/cataract-surgery-causes-biomechanical-alterations-to-the-eye-detectable-by-corvis-st-tonometry
#20
Yoshitake Kato, Shunsuke Nakakura, Ryo Asaoka, Kanae Matsuya, Yuki Fujio, Yoshiaki Kiuchi
PURPOSE: Modern cataract surgery is generally considered to bring about modest and sustained intraocular pressure (IOP) reduction. However, the pathophysiological mechanism for this remains unclear. Moreover, a change in ocular biomechanical properties after surgery can affect the measurement of IOP. The aim of the study is to investigate ocular biomechanics, before and following cataract surgery, using Corvis ST tonometry (CST). PATIENTS AND METHODS: Fifty-nine eyes of 59 patients with cataract were analyzed...
2017: PloS One
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