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Clinical trials

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https://www.readbyqxmd.com/read/28437852/a-diagnostic-microdosing-approach-to-investigate-platinum-sensitivity-in-non-small-cell-lung-cancer
#1
Si-Si Wang, Maike Zimmermann, Hongyong Zhang, Tzu-Yin Lin, Michael Malfatti, Kurt Haack, Kenneth W Turteltaub, George D Cimino, Ralph de Vere White, Chong-Xian Pan, Paul T Henderson
The platinum-based drugs cisplatin, carboplatin and oxaliplatin are often used for chemotherapy, but drug resistance is common. The prediction of resistance to these drugs via genomics is a challenging problem since hundreds of genes are involved. A possible alternative is to use mass spectrometry to determine the propensity for cells to form drug-DNA adducts-the pharmacodynamic drug-target complex for this class of drugs. The feasibility of predictive diagnostic microdosing was assessed in non-small cell lung cancer (NSCLC) cell culture and a pilot clinical trial...
April 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28437821/-rapid-cycling-in-bipolar-disorders-symptoms-%C3%A2-background%C3%A2-and-treatment-recommendations
#2
Stephan Köhler, Eva Friedel, Thomas Stamm
Rapid cycling bipolar disorder is encountered frequently in clinical practice with a lifetime prevalence of up to 31 %. Besides its association with greater illness severity, increased suicide and comorbidity rates, rapid cycling bipolar disorder has been closely associated with a longer and more complicated course of disease and inadequate treatment response compared to non-rapid cycling bipolar disorder. However rapid cycling does not serve as a stable characteristic of bipolar disorder, though its prevalence increases with illness duration...
April 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28437806/potential-of-bryophyllum-pinnatum-as-a-detrusor-relaxant-an-in-vitro-exploratory-study
#3
Simon Bachmann, Cornelia Betschart, Julia Gerber, Karin Fürer, Mónica Mennet, Matthias Hamburger, Olivier Potterat, Ursula von Mandach, Ana Paula Simões-Wüst
An earlier prospective, randomised, placebo-controlled clinical trial had suggested that Bryophyllum pinnatum might have potential in the treatment of overactive bladder. Here we investigated the effects of B. pinnatum leaf press juice, fractions enriched in flavonoids and bufadienolides, and a flavonoid aglycon mixture and individual aglycons on detrusor contractility as a major target in overactive bladder treatment. The strength of the detrusor contractions was investigated using porcine muscle strips stimulated with KCl...
April 24, 2017: Planta Medica
https://www.readbyqxmd.com/read/28437748/rational-and-timely-haemostatic-interventions-following-cardiac-surgery-coagulation-factor-concentrates-or-blood-bank-products
#4
Mariann Tang, Christian Fenger-Eriksen, Per Wierup, Jacob Greisen, Jørgen Ingerslev, Vibeke Hjortdal, Benny Sørensen
BACKGROUND: Cardiac surgery may cause a serious coagulopathy leading to increased risk of bleeding and transfusion demands. Blood bank products are commonly first line haemostatic intervention, but has been associated with hazardous side effect. Coagulation factor concentrates may be a more efficient, predictable, and potentially a safer treatment, although prospective clinical trials are needed to further explore these hypotheses. This study investigated the haemostatic potential of ex vivo supplementation of coagulation factor concentrates versus blood bank products on blood samples drawn from patients undergoing cardiac surgery...
April 5, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28437668/genome-wide-association-study-of-treatment-response-to-venlafaxine-xr-in-generalized-anxiety-disorder
#5
Jeesun Jung, Elisabeth A Tawa, Christine Muench, Allison D Rosen, Karl Rickels, Falk W Lohoff
We conducted the first genome-wide association study (GWAS) in Generalized Anxiety Disorder (GAD) to identify potential predictors of venlafaxine XR treatment outcome. Ninety-eight European American patients participated in a venlafaxine XR clinical trial for GAD, with Hamilton Anxiety Scale (HAM-A) response/remission at 24 weeks as the primary outcome measure. All participants were genotyped with the Illumina PsychChip, and 266,820 common single nucleotide polymorphisms (SNPs) were analyzed. Although no SNPs reached genome-wide significance, 8 SNPs were marginally associated with treatment response/remission and HAM-A reduction at week 12 and 24 (p<0...
April 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28437620/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-guidelines-for-management-of-dyslipidemia-and-prevention-of-cardiovascular-disease
#6
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols...
April 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28437539/safety-and-efficacy-of-antiviral-therapy-for-prevention-of-cytomegalovirus-reactivation-in-immunocompetent-critically-ill-patients-a-randomized-clinical-trial
#7
Nicholas J Cowley, Andrew Owen, Sarah C Shiels, Joanne Millar, Rebecca Woolley, Natalie Ives, Husam Osman, Paul Moss, Julian F Bion
Importance: Latent cytomegalovirus (CMV) infection is present in more than half the adult population, and a viral reactivation (ie, when the virus becomes measurable in body fluids such as blood) can occur in up to one-third of these individuals during episodes of critical illness. Objective: To determine whether antiviral therapy is safe and effective for preventing CMV reactivation in a general population of critically ill patients. Design, Setting, and Participants: A single-center, open-label, randomized, controlled clinical trial recruited 124 CMV-seropositive patients undergoing mechanical ventilation for at least 24 hours in the intensive care unit between January 1, 2012, and January 31, 2014...
April 24, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28437532/the-value-of-using-registries-to-evaluate-randomized-clinical-trial-study-populations
#8
Adam J Schoenfeld, Rita F Redberg
No abstract text is available yet for this article.
April 24, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28437521/home-based-trials-in-adolescent-migraine-a-randomized-clinical-trial
#9
Amy A Gelfand, William Qubty, Irene Patniyot, Barbara Grimes, Mark J Pletcher, Peter J Goadsby, Steven R Cummings
No abstract text is available yet for this article.
April 24, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28437520/academic-performance-motor-function-and-behavior-11-years-after-neonatal-caffeine-citrate-therapy-for-apnea-of-prematurity-an-11-year-follow-up-of-the-cap-randomized-clinical-trial
#10
Barbara Schmidt, Robin S Roberts, Peter J Anderson, Elizabeth V Asztalos, Lorrie Costantini, Peter G Davis, Deborah Dewey, Judy D'Ilario, Lex W Doyle, Ruth E Grunau, Diane Moddemann, Harvey Nelson, Arne Ohlsson, Alfonso Solimano, Win Tin
Importance: Caffeine citrate therapy for apnea of prematurity reduces the rates of bronchopulmonary dysplasia, severe retinopathy, and neurodevelopmental disability at 18 months and may improve motor function at 5 years. Objective: To evaluate whether neonatal caffeine therapy is associated with improved functional outcomes 11 years later. Design, Setting, and Participants: A follow-up study was conducted at 14 academic hospitals in Canada, Australia, and the United Kingdom from May 7, 2011, to May 27, 2016, of English- or French-speaking children who had been enrolled in the randomized, placebo-controlled Caffeine for Apnea of Prematurity trial between October 11, 1999, and October 22, 2004...
April 24, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28437508/comparative-evaluation-of-anesthetic-efficacy-of-2-lidocaine-4-articaine-and-0-5-bupivacaine-on-inferior-alveolar-nerve-block-in-patients-with-symptomatic-irreversible-pulpitis-a-prospective-randomized-double-blind-clinical-trial
#11
Vivek Aggarwal, Mamta Singla, Sanjay Miglani
AIMS: To compare the anesthetic efficacy of 1.8 mL of 2% lidocaine with 1:200,000 epinephrine, 4% articaine with 1:100,000 epinephrine, and 0.5% bupivacaine with 1:200,000 epinephrine on producing inferior alveolar nerve block (IANB) in patients with symptomatic irreversible pulpitis. METHODS: A total of 91 adult patients who were actively experiencing mandibular molar pain were involved in this study. The patients were randomly divided into three groups on the basis of the anesthetic solution used...
April 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28437438/use-of-the-matrics-consensus-cognitive-battery-mccb-to-evaluate-cognitive-deficits-in-bipolar-disorder-a-systematic-review-and-meta-analysis
#12
Qijing Bo, Zhen Mao, Xianbin Li, Zhimin Wang, Chuanyue Wang, Xin Ma
BACKGROUND: The Measurement and Treatment Research to Improve Cognition Schizophrenia Consensus Cognitive Battery (MCCB) has also been proposed for use in clinical trials to assess cognitive deficits in patients with bipolar disorder (BD). The aim of this study was to evaluate cognitive function assessed by the MCCB in BD. METHODS: A literature search of the PubMed, Embase, PsycINFO, SCI, Cochrane Library databases and the Cochrane Controlled Trials Register was conducted...
2017: PloS One
https://www.readbyqxmd.com/read/28437434/comparisons-of-gnrh-antagonist-protocol-versus-gnrh-agonist-long-protocol-in-patients-with-normal-ovarian-reserve-a-systematic-review-and-meta-analysis
#13
Ruolin Wang, Shouren Lin, Yong Wang, Weiping Qian, Liang Zhou
OBJECTIVE: To evaluate the effectiveness and safety of gonadotropin-releasing hormone antagonist (GnRH-ant) protocol and gonadotropin-releasing hormone agonist (GnRH-a) long protocol in patients with normal ovarian reserve. METHODS: We searched the PubMed (1992-2016), Cochrane Library (1999-2016), Web of Science (1950-2016), Chinese Biomedical Database (CBM, 1979-2016), and China National Knowledge Infrastructure (CNKI, 1994-2016). Any randomized controlled trials (RCTs) that compared GnRH-ant protocol and GnRH-a long protocol in patients with normal ovarian reserve were included, and data were extracted independently by two reviewers...
2017: PloS One
https://www.readbyqxmd.com/read/28437430/cerebellar-volume-as-imaging-outcome-in-progressive-multiple-sclerosis
#14
Matilde Inglese, Maria Petracca, Enricomaria Mormina, Anat Achiron, Rebecca Straus-Farber, Shmuel Miron, Michelle Fabian, Stephen Krieger, Aaron Miller, Fred Lublin, Maria Pia Sormani
BACKGROUND AND PURPOSE: To assess whether cerebellar volumes changes could represent a sensitive outcome measure in primary-progressive MS. MATERIAL AND METHODS: Changes in cerebellar volumes over one-year follow-up, estimated in 26 primary-progressive MS patients and 20 controls with Freesurfer longitudinal pipeline, were assessed using Wilcoxon test and tested for their correlation with disability worsening by a logistic regression. Clinical worsening was defined as EDSS score increase or change of >20% for 25-foot walk test or 9-hole peg test scores at follow-up...
2017: PloS One
https://www.readbyqxmd.com/read/28437392/should-we-administer-oxygen-during-an-acute-coronary-syndrome
#15
José Tomás Bennett-Laso, Tomás Kramer-Urrutia, Gabriel Rada
Oxygen therapy is used for the treatment of acute coronary syndrome without further discussion. However, the support of this practice in clinical research is scarce, ignoring the true effects of its implementation. To answer this question, we searched in Epistemonikos database, which is maintained by screening multiple information sources. We identified five systematic reviews including 12 studies overall, five of which were randomized trials. We extracted data, conducted a meta-analysis and generated a summary of findings table using the GRADE approach...
March 29, 2017: Medwave
https://www.readbyqxmd.com/read/28437278/pharmacodynamic-and-kinetic-behavior-of-low-intermediate-and-high-dose-landiolol-during-long-term-infusion-in-caucasians
#16
Günther Krumpl, Ivan Ulč, Michaela Trebs, Pavla Kadlecová, Juri Hodisch, Gabriele Maurer, Bernhard Husch
PK, PD, safety, and tolerability of long-term administration of landiolol, a fast-acting cardioselective β-blocker, were investigated for the first time in Caucasian subjects in a prospective clinical trial.Blood concentrations of landiolol and its metabolites, HR, BP and ECG parameters were studied in twelve healthy volunteers receiving continuous infusions of a new 12 mg/mL formulation of landiolol using a dose-escalation regimen (10 µg/kg BW/min for 2 hr, 20 µg/kg BW/min for 2 hr, 40 µg/kg BW/min for 20 hr, 6 hr follow-up)...
April 18, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28437264/magnesium-sulphate-improves-pulmonary-function-after-video-assisted-thoracoscopic-surgery-a-randomised-double-blind-placebo-controlled-study
#17
Hye-Min Sohn, Sang-Hoon Jheon, Sunwoo Nam, Sang-Hwan Do
BACKGROUND: Reduced lung volumes are unavoidable after lung resection surgery. Magnesium sulphate (MgSO4) administration has been reported to reduce the requirement for neuromuscular blocking drugs and postoperative analgesics in surgical patients. OBJECTIVE: To investigate the effect of MgSO4 on pulmonary function after video-assisted thoracoscopic surgery (VATS). DESIGN: A randomised, double-blind, placebo-controlled trial. SETTING: A university tertiary care centre...
April 21, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28437233/in-vitro-activity-of-various-antibiotics-in-combination-with-tigecycline-against-acinetobacter-baumannii-a-systematic-review-and-meta-analysis
#18
Jian Li, Xianghai Yang, Lidan Chen, Xinran Duan, Zhihui Jiang
Given that tigecycline-based combination therapy is recognized as a valuable option for the treatment of tigecycline-resistant Acinetobacter baumannii, we conducted this systematic review and meta-analysis to assess the overall evidence of its effectiveness. The synergy rate was defined as the primary outcome that was calculated separately for time-kill, Etest, and checkerboard microdilution methods. The secondary outcomes were bactericidal activity and the efficacy of combination treatment on the development of resistance...
April 24, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28437197/pressure-irrigation-of-surgical-incisions-and-traumatic-wounds
#19
Donald E Fry
BACKGROUND: Pressure irrigation of surgical incisions and traumatic wounds is commonly used to prevent infections. Commercial pressure irrigation devices have proliferated rapidly, but scientific validation of clinical benefit or appropriate use remains uncertain. METHODS: The published experimental and clinical investigations of pressure irrigation have been reviewed since the introduction of the Waterpik device in 1967 to identify the evidence for use to prevent soft tissue infections associated with injury wounds or surgical incisions...
March 1, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28437196/surgical-site-infection-and-colorectal-surgical-procedures-a-prospective-analysis-of-risk-factors
#20
E Carter Paulson, Earl Thompson, Najjia Mahmoud
BACKGROUND: Colorectal surgical procedures (CRS) are associated with the highest surgical site infection (SSI) rate among elective operations. A wide range of patient and surgical characteristics have been identified as risk factors for SSI. Most studies are limited by reliance on retrospective data or subset analysis of data that includes CRS. This study reflects analysis of SSI risk factors using prospectively collected data in an elective CRS population. PATIENTS AND METHODS: We analyzed data prospectively collected as part of a randomized, blinded trial of skin anti-sepsis in elective CRS to identify risk factors associated with SSI, including superficial or deep SSI or cellulitis within 30 days post-discharge...
February 22, 2017: Surgical Infections
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