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https://www.readbyqxmd.com/read/27920819/co-administration-of-metformin-and-n-acetylcysteine-with-dietary-control-improves-the-biochemical-and-histological-manifestations-in-rats-with-non-alcoholic-fatty-liver
#1
Naglaa Mohamed El-Lakkany, Sayed Hassan Seif El-Din, Abdel-Nasser Abdel-Aal Sabra, Olfat Ali Hammam, Fatma Abdel-Latif Ebeid
Non-alcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects 1/3 of the adult population and an increasing number of children in developed countries. Oxidative stress and insulin resistance are the mechanisms that seem to be mostly involved in its pathogenesis. This study was conceived in a NAFLD rat model to evaluate the efficacy of both metformin (MTF) and N-acetylcysteine (NAC) with dietary control on biochemical and histologic liver manifestations. Rats were classified into nine groups; normal (I), NAFLD-induced by feeding high-fat diet (HFD; II) for 12 weeks, NAFLD switched to regular diet (RD; III), NAFLD-HFD or -RD treated with MTF in a dose of 150 mg/kg (IV, V), NAC in a dose of 500 mg/kg (VI, VII) or MTF+NAC (VIII, IX) respectively for 8 weeks...
October 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27918048/nitrogen-doped-graphene-oxide-for-effectively-removing-boron-ions-from-seawater
#2
Fuming Chen, Lu Guo, Xiaoming Zhang, Zhi Yi Leong, Shengyuan Yang, Hui Ying Yang
Elemental boron exists in the form of boric acid or borate salts in aqueous solution. The human body is very sensitive to the amount of boron, and boron contamination in drinking water affects our health adversely. However, boron is not easily removed due to its small ionic size and is a problem to water treatment systems. Herein, we report a new method to remove boron using nitrogen-doped graphene oxide (N-GO). The maximum adsorption capacity we have obtained is 58.7 mg g(-1) and this makes N-GO one of the best materials to adsorb boron...
December 5, 2016: Nanoscale
https://www.readbyqxmd.com/read/27915340/2q33-1q34-deletion-in-a-girl-with-brain-anomalies-and-anorectal-malformation
#3
Luisa Ronzoni, Antonio Novelli, Giulia Brisighelli, Angela Peron, Fabio Triulzi, Vera Bianchi, Ernesto Leva, Maria F Bedeschi
2q33 deletions are considered to constitute a distinct clinical entity (Glass syndrome or 2q33 microdeletion syndrome) with a characteristic phenotype. Most patients have moderate to severe developmental delay, speech delay, a particular behavioural phenotype, feeding problems, growth restriction, a typical facial appearance, thin and sparse hair, tooth abnormalities, and skeletal anomalies. Here, we report on a patient with a 2q33.1q34 deletion spanning 8.3 Mb of genomic DNA. Although her clinical features are very reminiscent of the 2q33 microdeletion syndrome, she also presented with brain and anorectal malformations...
December 3, 2016: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/27914189/analysis-of-experiences-with-exclusive-breastfeeding-among-hiv-positive-mothers-in-lusaka-zambia
#4
Alice Ngoma-Hazemba, Busisiwe Purity Ncama
BACKGROUND: Exclusive breastfeeding in the first 6 months offers protection from postnatal HIV infection but remains low in resource-poor settings. Documentation of experiences with exclusive breastfeeding is needed to strengthen infant feeding counselling by health care workers. OBJECTIVE: To explore HIV-positive mothers' experiences with exclusive breastfeeding during the first 6 months of the infant's life. DESIGN: A health facility- and community-based exploratory qualitative study was conducted among 30 HIV-positive mothers practising exclusive breastfeeding and meeting the selection criteria...
2016: Global Health Action
https://www.readbyqxmd.com/read/27913774/gravity-flow-in-proposed-enteral-tube-small-bore-connectors
#5
Ryan T Hurt, Lisa M Epp, Adele K Pattinson, Wanda M Duellman, Stephen M Corner, Manpreet S Mundi
BACKGROUND: Enteral nutrition (EN) misconnections have been identified as a serious and potential deadly problem. An international effort led by EN industry leaders has developed a small-bore enteral connector (ENFit) that in theory will reduce the frequency of misconnections. Despite the potential benefit of preventing misconnections, the full impact of adoption of the ENFit connector is unknown. To assess the impact of transitioning to ENFit on our home EN (HEN) patients, the current study evaluated gravity feeding comparing 2 proposed small-bore connectors to the legacy (current connector) using various commercial formulas...
December 2, 2016: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/27911307/a-high-cholesterol-diet-increases-27-hydroxycholesterol-and-modifies-estrogen-receptor-expression-and-neurodegeneration-in-rabbit-hippocampus
#6
Sylwia W Brooks, Ava C Dykes, Bernard G Schreurs
Hypercholesterolemia has been implicated in numerous health problems from cardiovascular disease to neurodegeneration. High serum cholesterol levels in midlife have been associated with an increased risk of developing Alzheimer's disease (AD) later in life which suggests that the pathways leading to AD pathology might be activated decades before the symptoms of the disease are detected. Cholesterol-fed animals, particularly cholesterol-fed rabbits, exhibit brain pathology similar to the changes found in brains of AD patients...
November 28, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27910671/a-high-speed-compact-microwave-interferometer-for-density-fluctuation-measurements-in-sino-united-spherical-tokamak
#7
H Zhong, Y Tan, Y Q Liu, H Q Xie, Z Gao
A single-channel 3 mm interferometer has been developed for plasma density diagnostics in the Sino-UNIted Spherical Tokamak (SUNIST). The extremely compact microwave interferometer utilizes one corrugated feed horn antenna for both emitting and receiving the microwave. The beam path lies on the equatorial plane so the system would not suffer from beam path deflection problems due to the symmetry of the cross section. A focusing lens group and an oblique vacuum window are carefully designed to boost the signal to noise ratio, which allows this system to show good performance even with the small-diameter central column itself as a reflector, without a concave mirror...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27899532/long-term-management-for-ventilator-assisted-children-in-hong-kong-2-decades-experience
#8
Shuk-Kuen Chau, Ada Wing-Yan Yung, So-Lun Lee
BACKGROUND: The population of children receiving long-term mechanical ventilation is growing worldwide, but only limited data exist in Asian regions. The objective of the study was to review the management of these children in Hong Kong over the past 2 decades. METHODS: This was a retrospective cohort study. Hospital records from subjects receiving mechanical ventilation for >3 months were retrieved. Demographic characteristics and medical information of subjects (≤21 y old) under the care of the ventilator program at the Duchess of Kent Children's Hospital between 1997 and 2015 were reviewed...
November 29, 2016: Respiratory Care
https://www.readbyqxmd.com/read/27886468/practical-receiver-for-optimal-discrimination-of-binary-coherent-signals
#9
Denis Sych, Gerd Leuchs
We address the long-standing problem of discriminating coherent states with the minimum error rate. We show an optimum receiver for coherent states which admits a relatively simple implementation with current technologies. The receiver is based on multichannel splitting of the signal, followed by feed-forward signal displacement and photon-counting detection. We develop an optimal control strategy for a finite signal split and show convergence of the error rate to the Helstrom bound.
November 11, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27884168/ataxia-telangiectasia-a-review
#10
REVIEW
Cynthia Rothblum-Oviatt, Jennifer Wright, Maureen A Lefton-Greif, Sharon A McGrath-Morrow, Thomas O Crawford, Howard M Lederman
DEFINITION OF THE DISEASE: Ataxia telangiectasia (A-T) is an autosomal recessive disorder primarily characterized by cerebellar degeneration, telangiectasia, immunodeficiency, cancer susceptibility and radiation sensitivity. A-T is often referred to as a genome instability or DNA damage response syndrome. EPIDEMIOLOGY: The world-wide prevalence of A-T is estimated to be between 1 in 40,000 and 1 in 100,000 live births. CLINICAL DESCRIPTION: A-T is a complex disorder with substantial variability in the severity of features between affected individuals, and at different ages...
November 25, 2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27879968/can-urinary-indolylacroylglycine-iag-levels-be-used-to-determine-whether-children-with-autism-will-benefit-from-dietary-intervention
#11
Julie Wilson, Barry Wright, Sandra Jost, Robert Smith, Helen Pearce, Sally Richardson
BACKGROUND: An increase in urinary indolyl-3-acryloylglycine (IAG) has been reported in children with ASD who suffer with bowel problems in comparison to ASD children without gastrointestinal (GI) problems. The case for dietary intervention for ASD children with GI symptoms might be strengthened were such a difference to be autism-specific. METHODS: Quantitative analysis of urinary IAG levels was performed for 53 children on the autism spectrum and 146 age-matched controls...
November 23, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27879155/managing-cognition-in-progressive-supranuclear-palsy
#12
Timothy Rittman, Ian Ts Coyle-Gilchrist, James B Rowe
Cognitive impairment is integral to the syndrome of progressive supranuclear palsy. It is most commonly described as a frontal dysexecutive syndrome but other impairments include apathy, impulsivity, visuospatial and memory functions. Cognitive dysfunction may be exacerbated by mood disturbance, medication and communication problems. In this review we advocate an individualized approach to managing cognitive impairment in progressive supranuclear palsy with the education of caregivers as a central component...
December 2016: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/27875015/getting-evidence-based-pressure-ulcer-prevention-into-practice-a-process-evaluation-of-a-multi-faceted-intervention-in-a-hospital-setting
#13
Eva Sving, Lennart Fredriksson, Lena Gunningberg, Anna-Greta Mamhidir
AIM: The aim of the present study was to describe registered nurses', assistant nurses' and first-line managers' experiences and perceptions of a multi-faceted hospital setting intervention focused on implementing evidence-based pressure ulcer prevention. BACKGROUND: Pressure ulcer prevention is deficient. Different models exist to support implementation of evidence-based care. Little is known about implementation processes. DESIGN: A descriptive qualitative approach...
November 22, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27872967/l-methionine-production
#14
Jihyun Shim, Yonguk Shin, Imsang Lee, So Young Kim
L-Methionine has been used in various industrial applications such as the production of feed and food additives and has been used as a raw material for medical supplies and drugs. It functions not only as an essential amino acid but also as a physiological effector, for example, by inhibiting fat accumulation and enhancing immune response. Producing methionine from fermentation is beneficial in that microorganisms can produce L-methionine selectively using eco-sustainable processes. Nevertheless, the fermentative method has not been used on an industrial scale because it is not competitive economically compared with chemical synthesis methods...
November 22, 2016: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/27872656/nutritional-situation-among-syrian-refugees-hosted-in-iraq-jordan-and-lebanon-cross-sectional-surveys
#15
S M Moazzem Hossain, Eva Leidman, James Kingori, Abdullah Al Harun, Oleg O Bilukha
BACKGROUND: Ongoing armed conflict in Syria has caused large scale displacement. Approximately half of the population of Syria have been displaced including the millions living as refugees in neighboring countries. We sought to assess the health and nutrition of Syrian refugees affected by the conflict. METHODS: Representative cross-sectional surveys of Syrian refugees were conducted between October 2 and November 30, 2013 in Lebanon, April 12 and May 1, 2014 in Jordan, and May 20 and 31, 2013 in Iraq...
2016: Conflict and Health
https://www.readbyqxmd.com/read/27870751/breast-feeding-coparenting-framework-a-new-framework-to-improve-breast-feeding-duration-and-exclusivity
#16
Jennifer Abbass-Dick, Cindy-Lee Dennis
Targeting mothers and fathers in breast-feeding promotion programs is recommended as research has found that father's support positively impacts breast-feeding duration and exclusivity. Breast-feeding coparenting refers to the manner in which parents work together to achieve their breast-feeding goals. The Breast-feeding Coparenting Framework was developed on the basis of diverse coparenting models and research related to father's involvement with breast-feeding. This framework consists of 5 components: joint breast-feeding goal setting, shared breast-feeding responsibility, proactive breast-feeding support, father's/partner's parental-child interactions, and productive communication and problem solving...
January 2017: Family & Community Health
https://www.readbyqxmd.com/read/27870551/poor-feeding-and-severe-sedation-in-a-newborn-nursed-by-a-mother-on-a-low-dose-of-amitriptyline
#17
Faruk Uguz
Sleep problems are frequently seen during the postpartum period. Some mothers need to use sedative agents for insomnia. Amitriptyline is a tricyclic antidepressant that has sedative effects. Despite no adverse reports, data on safety for the maternal use of this medication on breastfed infants are limited. This case report presents severe sedation and poor feeding in the breastfed baby of a woman using amitriptyline at 10 mg/day.
November 21, 2016: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/27868158/growth-and-prevalence-of-feeding-difficulties-in-children-with-robin-sequence-a-retrospective-cohort-study
#18
Emma C Paes, Iris A C de Vries, Wouter M Penris, Karlijn H Hanny, Selma W Lavrijsen, Elselien K van Leerdam, Maaike M Rademaker, Esther S Veldhoen, Rene M J C Eijkemans, Moshe Kon, Corstiaan C Breugem
OBJECTIVES: In addition to breathing problems, patients with Robin sequence (RS) often encounter feeding difficulties (FD). Data regarding the occurrence of FD and possible influencing factors are scarce. The study aim was to elucidate these factors to improve treatment strategies. MATERIAL AND METHODS: A retrospective comparative cohort study was conducted, consisting of 69 infants diagnosed with both RS and a cleft palate and 64 isolated cleft palate only (iCPO) infants...
November 21, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27866490/multilevel-linear-regression-analysis-of-factors-influencing-body-mass-index-among-bangladeshi-married-non-pregnant-women
#19
Md Kamruzzaman, A S M A Mamun, Sheikh Muhammad Abu Bakar, Aik Saw, T Kamarul, Md Nurul Islam, Md Golam Hossain
The aim of this study was to investigate the socioeconomic and demographic factors influencing the body mass index (BMI) of non-pregnant married Bangladeshi women of reproductive age. Secondary (Hierarchy) data from the 2011 Bangladesh Demographic and Health Survey, collected using two-stage stratified cluster sampling, were used. Two-level linear regression analysis was performed to remove the cluster effect of the variables. The mean BMI of married non-pregnant Bangladeshi women was 21.60±3.86 kg/m2, and the prevalence of underweight, overweight and obesity was 22...
November 21, 2016: Journal of Biosocial Science
https://www.readbyqxmd.com/read/27863379/targeted-next-generation-sequencing-identifies-two-novel-mutations-in-sepn1-in-rigid-spine-muscular-dystrophy-1
#20
Yi Dai, Shengran Liang, Yan Huang, Lin Chen, Santasree Banerjee
Rigid spine muscular dystrophy 1 (RSMD1) is a neuromuscular disorder, manifested with poor axial muscle strength, scoliosis and neck weakness, and a variable degree of spinal rigidity with an early ventilatory insufficiency which can lead to death by respiratory failure. Mutations of SEPN1 gene are associated with autosomal recessive RSMD1. Here, we present a clinical molecular study of a Chinese proband with RSMD1. The proband is a 17 years old male, showing difficulty in feeding, delayed motor response, problem in running with frequent fall down, early onset respiratory insufficiency, general muscle weakness and rigid cervical spine...
November 14, 2016: Oncotarget
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