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https://www.readbyqxmd.com/read/29475160/immunotoxicity-of-ochratoxin-a-and-aflatoxin-b1-in-combination-is-associated-with-the-nuclear-factor-kappa-b-signaling-pathway-in-3d4-21-cells
#1
Lili Hou, Fang Gan, Xuan Zhou, Yajiao Zhou, Gang Qian, Zixuan Liu, Kehe Huang
The co-contamination of cereals, grains, crops, and animal feeds by mycotoxins is a universal problem. Humans and animals are exposed to several mycotoxins simultaneously as evidenced by extensive studies on this topic. Yet, most studies have addressed the effects of mycotoxins individually. Aflatoxin B1 and ochratoxin A can induce immunotoxicity. However, it remains unclear whether a combination of these mycotoxins aggravates immunotoxicity and the potential mechanism underlying this effect. In this study, we used the cell line 3D4/21, swine alveolus macrophages and innate immune cell...
February 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29474382/the-turkish-neonatal-jaundice-online-registry-a-national-root-cause-analysis
#2
Omer Erdeve, Emel Okulu, Ozgur Olukman, Dilek Ulubas, Gokhan Buyukkale, Fatma Narter, Gaffari Tunc, Begum Atasay, Nazli Dilay Gultekin, Saadet Arsan, Esin Koc
BACKGROUND: Neonatal jaundice (NNJ) is common, but few root cause analyses based on national quality registries have been performed. An online registry was established to estimate the incidence of NNJ in Turkey and to facilitate a root cause analysis of NNJ and its complications. METHODS: A multicenter prospective study was conducted on otherwise healthy newborns born at ≥35 weeks of gestation and hospitalized for only NNJ in 50 collaborator neonatal intensive care units across Turkey over a 1-year period...
2018: PloS One
https://www.readbyqxmd.com/read/29466715/ovine-liver-proteome-assessing-mechanisms-of-seasonal-weight-loss-tolerance-between-merino-and-damara-sheep
#3
Blake Miller, Nathalie Selevsek, Jonas Grossman, Tanya Kilminster, Tim Scanlon, Matthew Daniels, Paolo Nanni, John Milton, Chris Oldham, Johan Greef, Aspinas Chapwanya, Don Bergfelt, André M de Almeida
The effect of feed restriction on the liver protein profiles of two different breeds of sheep was studied. We compared Merino with the Damara, breeds with respectively low and high tolerance to nutritional stress. Each breed was grouped into two nutritional treatments: restricted (12-14% loss of live weight) and control (maintenance). The trial lasted 42 days. Animals were sacrificed and liver samples subjected to label free shotgun proteomics. The resultant proteins had both their fold change and statistical significance in an unpaired t-test calculated to identify differential protein abundance...
February 18, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29466401/assessing-the-potential-impacts-of-a-changing-climate-on-the-distribution-of-a-rabies-virus-vector
#4
Mark A Hayes, Antoinette J Piaggio
Common vampire bats (Desmodus rotundus) occur throughout much of South America to northern México. Vampire bats have not been documented in recent history in the United States, but have been documented within about 50 km of the U.S. state of Texas. Vampire bats feed regularly on the blood of mammals and can transmit rabies virus to native species and livestock, causing impacts on the health of prey. Thus cattle producers, wildlife management agencies, and other stakeholders have expressed concerns about whether vampire bats might spread into the southern United States...
2018: PloS One
https://www.readbyqxmd.com/read/29462361/wet-feed-and-cold-water-as-heat-stress-modulators-in-growing-muscovy-ducklings
#5
M F A Farghly, M E Abd El-Hack, M Alagawany, I M Saadeldin, A A Swelum
In an attempt to alleviate the deleterious effects of high summer temperatures, the present study investigated the effects of wet feed and cold water on the growth performance, carcass and meat quality, leg problems, physiological responses, and blood parameters of growing Muscovy ducklings. A total of 180 4-week-old ducklings was randomly divided into 6 experimental groups in a 3 × 2 factorial design that included 3 feed systems (AD: ad libitum dry; DW: diurnal wet; and AW: ad libitum wet) and 2 systems of water (TW: tap water; and CW: cold water)...
February 14, 2018: Poultry Science
https://www.readbyqxmd.com/read/29461377/total-lower-lip-reconstruction-with-functional-gracilis-free-muscle-flap
#6
Mehmet Akif Cakmak, Hakan Cinal, Ensar Zafer Barin, Muhammed Sedat Sakat, Harun Karaduman, Onder Tan
Free flaps based on static slings principles cannot provide esthetic and functional outcomes at a desired level in total or close to total lip loss. Therefore, dynamic methods have become a current issue in recent years and especially the idea of functional gracilis free muscle flap has been suggested. In this study, we present a case of a successful total lower lip repair with this flap.In a 78-year-old female patient who was diagnosed with squamous cell carcinoma involving the entire lower lip, bilateral modified radical neck dissection and full-thickness total resection with 1 cm surgical margin so as to include both commissures of the tumor were performed and then a free gracilis muscle flap was transferred from the same side...
February 14, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29460469/further-delineation-of-an-entity-caused-by-crebbp-and-ep300-mutations-but-not-resembling-rubinstein-taybi-syndrome
#7
Leonie A Menke, Thatjana Gardeitchik, Peter Hammond, Ketil R Heimdal, Gunnar Houge, Sophia B Hufnagel, Jianling Ji, Stefan Johansson, Sarina G Kant, Esther Kinning, Eyby L Leon, Ruth Newbury-Ecob, Stefano Paolacci, Rolph Pfundt, Nicola K Ragge, Tuula Rinne, Claudia Ruivenkamp, Sulagna C Saitta, Yu Sun, Marco Tartaglia, Paulien A Terhal, Anthony J van Essen, Magnus D Vigeland, Bing Xiao, Raoul C Hennekam
In 2016, we described that missense variants in parts of exons 30 and 31 of CREBBP can cause a phenotype that differs from Rubinstein-Taybi syndrome (RSTS). Here we report on another 11 patients with variants in this region of CREBBP (between bp 5,128 and 5,614) and two with variants in the homologous region of EP300. None of the patients show characteristics typical for RSTS. The variants were detected by exome sequencing using a panel for intellectual disability in all but one individual, in whom Sanger sequencing was performed upon clinical recognition of the entity...
February 20, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29460462/cri-du-chat-syndrome-characteristics-of-73-brazilian-patients
#8
R S Honjo, C B Mello, L S E Pimenta, E C Nuñes-Vaca, L M Benedetto, R B F Khoury, D M Befi-Lopes, C A Kim
BACKGROUND: Cri du Chat syndrome (CdCS) is a genetic syndrome caused by deletions in the short arm of chromosome 5. Although the main clinical features of CdCS are well known, the neurocognitive and behavioural characteristics of the phenotype are rarely described in detail in the literature. In this study, we analysed the main phenotypic features of CdCS from a parental perspective. METHOD: A questionnaire was sent to 700 Brazilian families that were registered in the Brazilian Association of CdCS...
February 20, 2018: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29458867/does-plant-microbe-interaction-confer-stress-tolerance-in-plants-a-review
#9
REVIEW
Akhilesh Kumar, Jay Prakash Verma
The biotic and abiotic stresses are major constraints for crop yield, food quality and global food security. A number of parameters such as physiological, biochemical, molecular of plants are affected under stress condition. Since the use of inorganic fertilizers and pesticides in agriculture practices cause degradation of soil fertility and environmental pollutions. Hence it is necessary to develop safer and sustainable means for agriculture production. The application of plant growth promoting microbes (PGPM) and mycorrhizal fungi enhance plant growth, under such conditions...
March 2018: Microbiological Research
https://www.readbyqxmd.com/read/29454502/prevalence-and-side-effects-of-pediatric-home-tube-feeding
#10
Hilde Krom, Suzanne M C van Zundert, Marie-Anne G M Otten, Liesbeth van der Sluijs Veer, Marc Alexander Benninga, Angelika Kindermann
BACKGROUND & AIMS: Tube feeding ensures growth, but can have negative effects on health and psychosocial functioning, resulting in health related costs. The aims of this study were to determine the prevalence of pediatric home tube feeding in the Netherlands and to assess the clinical characteristics of tube fed children and side effects of tube feeding. METHODS: The prevalence of pediatric home tube feeding was calculated using data (2010-2014) of both the Medicines and Devices Information Project of the National Health Care Institute, and Statistics Netherlands...
February 14, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29453632/microbiota-in-fermented-feed-and-swine-gut
#11
REVIEW
Cheng Wang, Changyou Shi, Yu Zhang, Deguang Song, Zeqing Lu, Yizhen Wang
Development of alternatives to antibiotic growth promoters (AGP) used in swine production requires a better understanding of their impacts on the gut microbiota. Supplementing fermented feed (FF) in swine diets as a novel nutritional strategy to reduce the use of AGP and feed price, can positively affect the porcine gut microbiota, thereby improving pig productivities. Previous studies have noted the potential effects of FF on the shift in benefit of the swine microbiota in different regions of the gastrointestinal tract (GIT)...
February 16, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29452190/toxicity-assessment-of-mycotoxins-extracted-from-contaminated-commercial-dog-pelleted-feed-on-canine-blood-mononuclear-cells
#12
Sanil D Singh, Naeem Sheik-Abdul, Alisa Phulukdaree, Charlette Tiloke, Savani Nagiah, Sooraj Baijnath, Anil A Chuturgoon
Raw ingredients of pet food are often contaminated with mycotoxins. This is a serious health problem to pets and causes emotional and economical stress to the pet owners. The aim of this study was to determine the immunotoxicity of the most common mycotoxins (aflatoxin, fumonisin, ochratoxin A and zearalenone) by examining 20 samples of extruded dry dog food found on the South African market [10 samples from standard grocery store lines (SB), 10 from premium veterinarian lines (PB)]. Pelleted dog food was subjected to extraction protocols optimized for the above mentioned mycotoxins...
February 13, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29447830/syngnathia-congenital-maxillomandibular-fusion-case-report-and-literature-review
#13
REVIEW
Amit Mohan
Congenital maxillomandibular fusion is a rare disorder of the craniofacial region. Maintenance of the airway and difficulty in feeding are the main concerns for such patients. We performed a PubMed search to identify reported cases of syngnathia. With reference to the site of fusion and corresponding anomalies, the available studies were reviewed. The maxillomandibular fusion can be anterior fusion, unilateral or bilateral fusion, and complete fusion. The condition can be an isolated problem or associated with a syndrome...
February 2, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29437908/a-quality-improvement-initiative-to-reduce-nicu-transfers-for-neonates-at-risk-for-hypoglycemia
#14
Sherry LeBlanc, Jamie Haushalter, Carl Seashore, Karen S Wood, Michael J Steiner, Ashley G Sutton
BACKGROUND AND OBJECTIVE: Neonatal hypoglycemia is a common problem, often requiring management in the NICU. Nonpharmacologic interventions, including early breastfeeding and skin-to-skin care (SSC), may prevent hypoglycemia and the need to escalate care. Our objective was to maintain mother-infant dyads in the mother-infant unit by decreasing hypoglycemia resulting in NICU transfer. METHODS: Inborn infants ≥35 weeks' gestation with at least 1 risk factor for hypoglycemia were included...
February 8, 2018: Pediatrics
https://www.readbyqxmd.com/read/29434700/distinct-magnetic-resonance-imaging-features-in-a-patient-with-novel-rars2-mutations-a-case-report-and-review-of-the-literature
#15
Jie Zhang, Zhongbin Zhang, Yao Zhang, Ye Wu
Pontocerebellar hypoplasia type 6 (PCH6) is a rare autosomal recessive disease that occurs due to mutations in the mitochondrial arginyl-tRNA synthetase 2 (RARS2) gene. To the best of our knowledge, 23 cases with relatively complete clinical data have been reported thus far. In the present study, a case with PCH6 caused by novel RARS2 mutations is described, in which distinct magnetic resonance imaging (MRI) features were identified. In addition, 23 PCH6 cases found in the literature were reviewed. Early onset hypotonia (43...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29429411/gastro-oesophageal-reflux-a-mixed-methods-study-of-infants-admitted-to-hospital-in-the-first-12%C3%A2-months-following-birth-in-nsw-2000-2011
#16
Hannah Grace Dahlen, Jann P Foster, Kim Psaila, Kaye Spence, Nadia Badawi, Cathrine Fowler, Virginia Schmied, Charlene Thornton
BACKGROUND: Gastro-oesophageal reflux (GOR) is common in infants. When the condition causes pathological symptoms and/or complications it is considered gastro-oesophageal reflux disease (GORD). It appears to be increasingly diagnosed and causes great distress in the first year of infancy. In New South Wales (NSW), residential parenting services support families with early parenting difficulties. These services report a large number of babies admitted with a label of GOR/GORD. The aim of this study was to explore the maternal and infant characteristics, obstetric interventions, and reasons for clinical reporting of GOR/GORD in NSW in the first 12 months following birth (2000-2011)...
February 12, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29428545/the-montreal-children-s-hospital-feeding-scale-relationships-with-parental-report-of-child-eating-behaviours-and-observed-feeding-interactions
#17
Samantha Rogers, Maria Ramsay, Jackie Blissett
Feeding problems are common, with implications for nutrition, growth and family stress, placing burden on primary care services. The Montreal Children's Hospital Feeding Scale (MCHFS) is a quick and reliable measure of feeding problems for clinical settings, but there is little examination of its relationship to commonly used research measures of parental feeding practice, child eating behaviour and observations of parent-infant interaction at mealtimes. We examined the relationships between the MCHFS, demographics and early feeding history, weight across the first year, parental report of feeding practices and child eating behaviours, and observations of maternal-infant feeding interaction at 1 year...
February 8, 2018: Appetite
https://www.readbyqxmd.com/read/29422348/microplastics-no-small-problem-for-filter-feeding-megafauna
#18
Elitza S Germanov, Andrea D Marshall, Lars Bejder, Maria Cristina Fossi, Neil R Loneragan
Microplastic pollution can impact filter-feeding marine megafauna, namely mobulid rays, filter-feeding sharks, and baleen whales. Emerging research on these flagship species highlights potential exposure to microplastic contamination and plastic-associated toxins. Research and its wide communication are needed to understand the magnitude of the issue and improve marine stewardship.
February 5, 2018: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/29422330/enhancement-of-cell-growth-and-phycocyanin-production-in-arthrospira-spirulina-platensis-by-metabolic-stress-and-nitrate-fed-batch
#19
Emmanuel Manirafasha, Theophile Murwanashyaka, Theoneste Ndikubwimana, Nur Rashid Ahmed, Jingyi Liu, Yinghua Lu, Xianhai Zeng, Xueping Ling, Keju Jing
Arthrospira (Spirulina) platensis is known to have high-quality proteins content and phycocyanin as one of the major pigment constituents of the cells, and the most challenging problem associated with phycocyanin production in Arthrospira is to optimize its intracellular accumulation. The present study evaluated the metabolic stress conditions (by nutrient enrichment) of Arthrospira platensis FACHB-314 for boosting biomass growth and high content phycocyanin accumulation. Experimental results showed that 5 mM sodium glutamate and 7...
December 23, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29422195/practice-based-interpretation-of-ultrasound-studies-leads-the-way-to-more-effective-clinical-support-and-less-pharmaceutical-and-surgical-intervention-for-breastfeeding-infants
#20
REVIEW
Pamela Douglas, Donna Geddes
BACKGROUND: breastfeeding optimises health outcomes for both mothers and infants. Although most women want to breastfeed, they report commencing infant formula because of nipple pain, unsettled infant behaviour, and infant growth concerns. To date, existing approaches to fit and hold ('latch and positioning') have been demonstrated not to help breastfeeding outcomes, and women report widespread dissatisfaction with the quality of support and conflicting advice they receive. Breast and nipple pain, difficulty with latching and sucking, fussing at the breast, back-arching, marathon feeds, excessively frequent feeds, poor weight gain, breast refusal, and crying due to poor satiety often signal suboptimal positional instability and impaired milk transfer, but may be misdiagnosed as medical conditions...
March 2018: Midwifery
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