Read by QxMD icon Read


Véronique Hugouvieux, Catarina S Silva, Agnès Jourdain, Arnaud Stigliani, Quentin Charras, Vanessa Conn, Simon J Conn, Cristel C Carles, François Parcy, Chloe Zubieta
The MADS transcription factors (TF) constitute an ancient family of TF found in all eukaryotes that bind DNA as obligate dimers. Plants have dramatically expanded the functional diversity of the MADS family during evolution by adding protein-protein interaction domains to the core DNA-binding domain, allowing the formation of heterotetrameric complexes. Tetramerization of plant MADS TFs is believed to play a central role in the evolution of higher plants by acting as one of the main determinants of flower formation and floral organ specification...
March 19, 2018: Nucleic Acids Research
Tao Zhang, Ülo Niinemets, Justin Sheffield, Jeremy W Lichstein
Forests have a key role in global ecosystems, hosting much of the world's terrestrial biodiversity and acting as a net sink for atmospheric carbon. These and other ecosystem services that are provided by forests may be sensitive to climate change as well as climate variability on shorter time scales (for example, annual to decadal). Previous studies have documented responses of forest ecosystems to climate change and climate variability, including drought-induced increases in tree mortality rates. However, relationships between forest biomass, tree species composition and climate variability have not been quantified across a large region using systematically sampled data...
March 21, 2018: Nature
Devram S Ghorpade, Lale Ozcan, Ze Zheng, Sarah M Nicoloro, Yuefei Shen, Emily Chen, Matthias Blüher, Michael P Czech, Ira Tabas
Obesity-induced metabolic disease involves functional integration among several organs via circulating factors, but little is known about crosstalk between liver and visceral adipose tissue (VAT). In obesity, VAT becomes populated with inflammatory adipose tissue macrophages (ATMs). In obese humans, there is a close correlation between adipose tissue inflammation and insulin resistance, and in obese mice, blocking systemic or ATM inflammation improves insulin sensitivity. However, processes that promote pathological adipose tissue inflammation in obesity are incompletely understood...
March 21, 2018: Nature
Klaus Geissler, Matthias Gunzer, Helmut Ostermann
No abstract text is available yet for this article.
March 23, 2018: Oncology Research and Treatment
Lidija Radovanović, Jelena Rogan, Dejan Poleti, V Marko Rodić, Zvonko Jagličić
Two new isostructural M(II) (M = Ni, Co) complexes with 2,2'-dipyridylamine (dipya) and dianion of terephthalic acid (H2tpht), [M(dipya)2(H2O)2](tpht) ∙ 2H2O, have been synthesized by ligand exchange reaction and characterized by single-crystal X-ray diffraction, FTIR spectroscopy, TG/DSC analysis and magnetic measurements. The crystal structures of [M(dipya)2(H2O)2](tpht) ∙ 2H2O consist of discrete complex units in which M(II) adopts deformed octahedral geometries. Two dipya ligands and two water molecules are coordinated to M(II) atom, tpht acts as a counter ion, while additional two water molecules remained uncoordinated...
March 2018: Acta Chimica Slovenica
G C L Gracindo, J H da Silva Gallo, R Nunes
We aimed to outline the profile of medical professionals in Brazil who have violated the deontological norms set forth in the ethics code of the profession, and whose cases were judged by the higher tribunal for medical ethics between 2010 and 2016. This survey was conducted using a database formed from professional ethics cases extracted from the plenary of the medical ethics tribunal of the Federal Council of Medicine. These were disciplinary ethics cases that were judged at appeal level between 2010 and 2016...
March 15, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Narmada Sambaturu, Sumanta Mukherjee, Martín López-García, Carmen Molina-París, Gautam I Menon, Nagasuma Chandra
Genetic differences contribute to variations in the immune response mounted by different individuals to a pathogen. Such differential response can influence the spread of infectious disease, indicating why such diseases impact some populations more than others. Here, we study the impact of population-level genetic heterogeneity on the epidemic spread of different strains of H1N1 influenza. For a population with known HLA class-I allele frequency and for a given H1N1 viral strain, we classify individuals into sub-populations according to their level of susceptibility to infection...
March 21, 2018: PLoS Computational Biology
Noel Lianga, Carole Doré, Erin K Kennedy, Elaine Yeh, Elizabeth C Williams, Camille Marie Fortinez, Alick Wang, Kerry S Bloom, Adam D Rudner
Anaphase onset is an irreversible cell cycle transition that is triggered by the activation of the protease Separase. Separase cleaves the Mcd1 (also known as Scc1) subunit of Cohesin, a complex of proteins that physically links sister chromatids, triggering sister chromatid separation. Separase is regulated by the degradation of the anaphase inhibitor Securin which liberates Separase from inhibitory Securin/Separase complexes. In many organisms, Securin is not essential suggesting that Separase is regulated by additional mechanisms...
March 21, 2018: PLoS Genetics
Nicholas Z Muller, Peter Hans Matthews, Virginia Wiltshire-Gordon
This paper calculates the distribution of an adjusted measure of income that deducts damages due to exposure to air pollution from reported market income in the United States from 2011 to 2014. The Gini coefficient for this measure of adjusted income is 0.682 in 2011, as compared to 0.482 for market income. By 2014, we estimate that the Gini for adjusted income fell to 0.646, while the market income Gini did not appreciably change. The inclusion of air pollution damage acts like a regressive tax: with air pollution, the bottom 20% of households lose roughly 10% of the share of income, while the top 20% of households gain 10%...
2018: PloS One
Maria Mrakovcic, Leopold F Fröhlich
Autophagy is an indispensable mechanism of the eukaryotic cell, facilitating the removal and renewal of cellular components and thereby balancing the cell's energy consumption and homeostasis. Deregulation of autophagy is now regarded as one of the characteristic key features contributing to the development of tumors. In recent years, the suppression of autophagy in combination with chemotherapeutic treatment has been approached as a novel therapy in cancer treatment. However, depending on the type of cancer and context, interference with the autophagic machinery can either promote or disrupt tumorigenesis...
March 21, 2018: Biomolecules
John Tingle
John Tingle discusses the latest Care Quality Commission annual report on how health services in England are applying the Mental Health Act 1983, which reveals with some worrying findings.
March 22, 2018: British Journal of Nursing: BJN
Jessica Henoch, Armin Auch, Fatima Diab, Klaus Eichele, Hartmut Schubert, Peter Sirsch, Theresa Block, Rainer Pöttgen, Lars Wesemann
1,1'-Dilithioferrocene was reacted with 2 equiv of isopropyl (Ar*) or methyl (Ar') substituted terphenyl tin(II) chloride. Reaction product 1, carrying the bulkier terphenyl substituent Ar*, displays a bis(stannylene) structure in the solid state without formation of a tin-tin bond. Temperature-dependent solution119 Sn NMR spectroscopy, however, revealed a dynamic interplay between bis(stannylene) (100 °C) and cyclic distannene (-80 °C). In contrast to 1, the less bulky Ar' substituent results in a cyclic distannene 2...
March 21, 2018: Inorganic Chemistry
Eduardo Guisasola, Laura Asín, Lillianne Beola, Jesús M De La Fuente, Alejandro Baeza, María Vallet Regí
This work presents an innovation in the tumor treatment in vivo mediated by magnetic mesoporous silica nanoparticles (MMSNs). This device was built with iron oxide magnetic nanoparticles embedded in a mesoporous silica matrix and coated with an engineered thermoresponsive polymer. The magnetic nanoparticles act as internal heating sources under an alternating magnetic field (AMF) that increase the temperature of the surroundings, provoking the polymer transition and consequently the release of a drug trapped inside the silica pores...
March 21, 2018: ACS Applied Materials & Interfaces
Kylie Wheelock, Junfeng Jim Zhang, Rob McConnell, Deliang Tang, Heather E Volk, Ya Wang, Julie B Herbstman, Shuang Wang, David H Phillips, David Camann, Jicheng Gong, Frederica Perera
Polycyclic aromatic hydrocarbons (PAH) are ubiquitous air pollutants associated with negative impacts on growth, development and behavior in children. Source-specific biological markers of PAH exposure are needed for targeting interventions to protect children. Nitro-derivatives of PAH can act as markers of exposure to diesel exhaust, gasoline exhaust, or general combustion sources. Using a novel HPLC-APCI-MS/MS detection method, we examined four hemoglobin (Hb) adducts of nitro-PAH metabolites and the Hb adduct of a benzo[a]pyrene (BaP) metabolite in 22 umbilical cord blood samples...
March 21, 2018: Environmental Science. Processes & Impacts
Dean A VanNasdale, Ann E Elsner, Victor E Malinovsky, Todd D Peabody, Kimberly D Kohne, Bryan P Haggerty, Christopher A Clark
SIGNIFICANCE: Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss. Complementary imaging techniques can be used to better characterize and quantify pathological changes associated with AMD. By assessing specific light-tissue interactions, polarization-sensitive imaging can be used to detect tissue disruption early in the disease process. PURPOSE: The aim of this study was to compare variability in central macular polarization properties in patients with nonexudative AMD and age-matched control subjects...
March 21, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Adel Schwertani, Hong Y Choi, Jacques Genest
PURPOSE OF REVIEW: Plasma levels of HDL cholesterol are a biomarker of cardiovascular health but not a therapeutic target, as demonstrated by the failure of pharmacological modulation of HDL cholesterol to prevent or treat atherosclerotic cardiovascular disease. In health, HDL particles exert pleiotropic effects against atherosclerosis, including cholesterol removal from foam cells, vasodilatory effects through vascular endothelial cell nitric oxide production, decreased vascular inflammation and oxidative damage, endothelial cell proliferation and antiapoptotic effects...
March 19, 2018: Current Opinion in Cardiology
Benjamin Richard, Richard Swanson, Gonzalo Izaguirre, Steven Thomas Olson
Heparin allosterically activates the anticoagulant serpin, antithrombin, by binding through a sequence-specific pentasaccharide and inducing activating conformational changes in the protein. Three basic residues of antithrombin, Lys114, Lys125 and Arg129, have been shown to be hotspots for binding the pentasaccharide, but the molecular basis for such hotspot binding has been unclear. To determine whether this results from cooperative interactions, we analyzed the effects of single, double and triple mutations of the hotspot residues on pentasaccharide binding and activation of antithrombin...
March 21, 2018: Biochemistry
N Dri Marcel Kouassi
Improving transfusion chain requires moral support for blood policy and ethics training of different actors. To optimize this support and ethics training, it is important to evaluate and strengthen the ethicality of the mandates of the structures involved in the transfusion chain. To help strengthen audit, this study will examine the use of anticipatory and forward slope of the principle of ethical responsibility in the blood policy in Quebec and Côte d'Ivoire. By elucidating the conditionalities of efficient use of accountability within these transfusion chain, this paper deepens the fundamentals of acting rational, sensible, prudential and therefore responsible to his blood systems and supports, at the same time the ideas of biomonitoring and preventive medicine...
May 22, 2017: Journal International de Bioéthique et D'éthique des Sciences
Aída Kemelmajer de Carlucci
The new Argentine Civil and Commercial Code includes the prevention principle. The precautionary Principle is regulated by the Environmental Protection Act.A significant number of cases have reached the Supreme Court of the Nation. This Court, in general, estimates that the decisions concerning the precautionary principle have definitive nature, i.e., are not merely provisional. Usually, the situation is caused by the State itself, which fails to control. The different decisions show a Judiciary worried about protecting the environment...
October 13, 2017: Journal International de Bioéthique et D'éthique des Sciences
Astrid Marais
By allowing a woman to terminate the life of the embryo, the law of 17 January 1975 leads us to ask the question about how to qualify the embryo. Is it a thing or a person ? Subordinate to the birth of a viable, living being, the embryo can have no acknowledged legal personality. Its particularity must nevertheless be noted : it is the only thing in law that is likely to become a person. So, conjugated in the present (The reality of the present : the embryo is a thing), the embryo is without doubt a thing.This qualification is implicit and results from an a contrario interpretation of article 16 CC...
March 7, 2018: Journal International de Bioéthique et D'éthique des Sciences
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"