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https://www.readbyqxmd.com/read/27925384/co-micellized-pluronic-mixture-with-thermo-sensitivity-and-residence-stability-as-an-injectable-tissue-adhesion-barrier-hydrogel
#1
Se Heang Oh, Jun Goo Kang, Jin Ho Lee
Although the tissue adhesion which leads to various complications frequently occurs after surgery, the development of an ideal tissue adhesion barrier is still a challenge. In this study, a thermo-sensitive hydrogel, which can fulfill the essential requirements of tissue adhesion barrier (that is, ease of handling for surgeon, flowing down prevention after application, stable residence on the injury during wound healing, and no use of toxic additives), was developed using biocompatible polyethylene glycol-polypropylene glycol copolymers (Pluronic F127/F68/P123 mixture)...
December 7, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27924670/safety-of-iphone-retinal-photography
#2
Sheng Chiong Hong, Giles Wynn-Williams, Graham Wilson
BACKGROUND: With the advancement in mobile technology, smartphone retinal photography is becoming a popular practice. However, there is limited information about the safety of the latest smartphones used for retinal photography. AIMS: This study aims to determine the photobiological risk of iPhone 6 and iPhone 6 plus when used in conjunction with a 20Diopter condensing lens for retinal photography. METHOD: iPhone 6 and iPhone 6 plus (Apple, Cupertino, CA) were used in this study...
December 7, 2016: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/27924269/importance-of-consensus-region-of-multiple-ligand-templates-in-a-virtual-screening-method
#3
Tatsuya Okuno, Koya Kato, Shintaro Minami, Tomoki P Terada, Masaki Sasai, George Chikenji
We discuss methods and ideas of virtual screening (VS) for drug discovery by examining the performance of VS-APPLE, a recently developed VS method, which extensively utilizes the tendency of single binding pockets to bind diversely different ligands, i.e. promiscuity of binding pockets. In VS-APPLE, multiple ligands bound to a pocket are spatially arranged by maximizing structural overlap of the protein while keeping their relative position and orientation with respect to the pocket surface, which are then combined into a multiple-ligand template for screening test compounds...
2016: Biophysics and Physicobiology
https://www.readbyqxmd.com/read/27921398/effects-of-rhizobacteria-paenibacillus-polymyxa-apec136-and-bacillus-subtilis-apec170-on-biocontrol-of-postharvest-pathogens-of-apple-fruits
#4
Young Soo Kim, Kotnala Balaraju, Yongho Jeon
In this study, plant growth-promoting rhizobacteria (PGPR) were evaluated as potential biocontrol agents against postharvest pathogens of apple fruits. In vitro bioassays revealed that, out of 30 isolates screened, isolates APEC136 and APEC170 had the most significant inhibitory effects against the mycelial growth of several fungal pathogens. Analysis of 16S ribosomal RNA (rRNA) sequences identified the two effective isolates as Paenibacillus polymyxa and Bacillus subtilis, respectively. The two strains showed greater growth in brain-heart infusion broth than in other growth media...
2016: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/27920969/examining-the-effects-of-video-modeling-and-prompts-to-teach-activities-of-daily-living-skills
#5
Catarina Aldi, Alexandra Crigler, Kelly Kates-McElrath, Brian Long, Hillary Smith, Kim Rehak, Lisa Wilkinson
Video modeling has been shown to be effective in teaching a number of skills to learners diagnosed with autism spectrum disorders (ASD). In this study, we taught two young men diagnosed with ASD three different activities of daily living skills (ADLS) using point-of-view video modeling. Results indicated that both participants met criterion for all ADLS. Participants did not maintain mastery criterion at a 1-month follow-up, but did score above baseline at maintenance with and without video modeling. • Point-of-view video models may be an effective intervention to teach daily living skills...
December 2016: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/27919735/quercetin-attenuates-high-fructose-feeding-induced-atherosclerosis-by-suppressing-inflammation-and-apoptosis-via-ros-regulated-pi3k-akt-signaling-pathway
#6
Xue-Li Lu, Cui-Hua Zhao, Xin-Liang Yao, Han Zhang
Quercetin is a dietary flavonoid compound extracted from various plants, such as apple and onions. Previous studies have revealed its anti-inflammatory, anti-cancer, antioxidant and anti-apoptotic activities. This study investigated the ability of quercetin to inhibit high fructose feeding- or LPS-induced atherosclerosis through regulating oxidative stress, apoptosis and inflammation response in vivo and in vitro experiments. 50 and 100mg/kg quercetin were used in our study, showing significant inhibitory role in high fructose-induced atherosclerosis via reducing reactive oxygen species (ROS) levels, Caspase-3 activation, inflammatory cytokines releasing, the number of terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL)-positive cells and collagen contents as well as modulating apoptosis- and inflammation-related proteins expression...
December 2, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27919669/manothermosonication-mts-treatment-of-apple-carrot-juice-blend-for-inactivation-of-escherichia-coli-0157-h7
#7
Ozan Kahraman, Hyoungill Lee, Wei Zhang, Hao Feng
This study was performed to evaluate the responses of Escherichia coli 0157:H7 inoculated in an apple-carrot blended juice to manothermosonication (MTS) treatments. The MTS treatments were conducted in a continuous-flow MTS system. The juice samples were exposed to ultrasound treatment at combinations of three temperatures (60, 50 and 40°C) and three pressure levels (100, 200, and 300kPa) for five residence times (15, 30, 45, 60, and 75s). The results showed that higher treatment temperature (i.e. 60°C) and hydrostatic pressure in the MTS system significantly enhanced the microbial reduction...
November 24, 2016: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/27918614/effects-of-juice-matrix-and-pasteurization-on-stability-of-black-currant-anthocyanins-during-storage
#8
Gary Dobson, Gordon J McDougall, Derek Stewart, Miguel Ángel Cubero, Reijo O Karjalainen
The effects of juice matrix and pasteurization on the stability of total phenols and especially total and individual anthocyanins were examined in black currant (BC) juice and mixtures with apple, persimmon, and peach juices at 4 °C and 20 °C. Total phenol content decreased in all juices at both temperatures but there was a trend to lower levels in unpasteurized over pasteurized juices. Differences in the decline of total anthocyanins between pasteurized and unpasteurized juices varied according to the juice type and the storage temperature...
December 5, 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27918417/efficacy-of-nitric-oxide-fumigation-for-controlling-codling-moth-in-apples
#9
Yong-Biao Liu, Xiangbing Yang, Gregory Simmons
Nitric oxide (NO) fumigation under ultralow oxygen (ULO) conditions was studied for its efficacy in controlling codling moth and effects on postharvest quality of apples. NO fumigation was effective against eggs and larvae of different sizes on artificial diet in 48 h treatments. Small larvae were more susceptible to nitric oxide than other stages at 0.5% NO concentration. There were no significant differences among life stages at 1.0% to 2.0% NO concentrations. In 24 h treatments of eggs, 3.0% NO fumigation at 2 °C achieved 100% egg mortality...
December 2, 2016: Insects
https://www.readbyqxmd.com/read/27917839/characterization-and-1-57%C3%A2-%C3%A3-resolution-structure-of-the-key-fire-blight-phosphatase-amsi-from-erwinia-amylovora
#10
Marco Salomone-Stagni, Francesco Musiani, Stefano Benini
AmsI is a low-molecular-weight protein tyrosine phosphatase that regulates the production of amylovoran in the Gram-negative bacterium Erwinia amylovora, a specific pathogen of rosaceous plants such as apple, pear and quince. Amylovoran is an exopolysaccharide that is necessary for successful infection. In order to shed light on AmsI, its structure was solved at 1.57 Å resolution at the same pH as its highest measured activity (pH 5.5). In the active site, a water molecule, bridging between the catalytic Arg15 and the reaction-product analogue sulfate, might be representative of the water molecule attacking the phospho-cysteine intermediate in the second step of the reaction mechanism...
December 1, 2016: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/27917289/a-high-density-multi-parental-snp-genetic-map-on-apple-validates-a-new-mapping-approach-for-outcrossing-species
#11
Erica A Di Pierro, Luca Gianfranceschi, Mario Di Guardo, Herma Jj Koehorst-van Putten, Johannes W Kruisselbrink, Sara Longhi, Michela Troggio, Luca Bianco, Hélène Muranty, Giulia Pagliarani, Stefano Tartarini, Thomas Letschka, Lidia Lozano Luis, Larisa Garkava-Gustavsson, Diego Micheletti, Marco Cam Bink, Roeland E Voorrips, Ebrahimi Aziz, Riccardo Velasco, François Laurens, W Eric van de Weg
Quantitative trait loci (QTL) mapping approaches rely on the correct ordering of molecular markers along the chromosomes, which can be obtained from genetic linkage maps or a reference genome sequence. For apple (Malus domestica Borkh), the genome sequence v1 and v2 could not meet this need; therefore, a novel approach was devised to develop a dense genetic linkage map, providing the most reliable marker-loci order for the highest possible number of markers. The approach was based on four strategies: (i) the use of multiple full-sib families, (ii) the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism (SNP) markers, (iii) the construction of a single backcross-type data set including all families, and (iv) a two-step map generation procedure based on the sequential inclusion of markers...
2016: Horticulture Research
https://www.readbyqxmd.com/read/27913847/patulin-transformation-products-and-last-intermediates-in-its-biosynthetic-pathway-e-and-z-ascladiol-are-not-toxic-to-human-cells
#12
Joanna Tannous, Selma P Snini, Rhoda El Khoury, Cécile Canlet, Philippe Pinton, Yannick Lippi, Imourana Alassane-Kpembi, Thierry Gauthier, André El Khoury, Ali Atoui, Ting Zhou, Roger Lteif, Isabelle P Oswald, Olivier Puel
Patulin is the main mycotoxin contaminating apples. During the brewing of alcoholic beverages, this mycotoxin is degraded to ascladiol, which is also the last precursor of patulin. The present study aims (1) to characterize the last step of the patulin biosynthetic pathway and (2) to describe the toxicity of ascladiol. A patE deletion mutant was generated in Penicillium expansum. In contrast to the wild strain, this mutant does not produce patulin but accumulates high levels of E-ascladiol with few traces of Z-ascladiol...
December 2, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27911881/low-energy-ne-ion-beam-induced-modifications-of-magnetic-properties-in-mnas-thin-films
#13
M Trassinelli, L Bernard Carlsson, S Cervera, M Eddrief, V H Etgens, E V Gafton, E Lacaze, E Lamour, A Lévy, S Macé, C Prigent, J-P Rozet, S Steydli, M Marangolo, D Vernhet
Investigations of the complex behavior of the magnetization of manganese arsenide thin films due to defects induced by irradiation of slow heavy ions are presented. In addition to the thermal hysteresis suppression already highlighted in Trassinelli et al (2014 Appl. Phys. Lett. 104 081906), we report here on new local magnetic features recorded by a magnetic force microscope at different temperatures close to the characteristic sample phase transition. Complementary measurements of the global magnetization in different conditions (applied magnetic field and temperatures) enable the film characterization to be completed...
December 2, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/27910871/noncontact-and-wide-field-characterization-of-the-absorption-and-scattering-properties-of-apple-fruit-using-spatial-frequency-domain-imaging
#14
Dong Hu, Xiaping Fu, Xueming He, Yibin Ying
Spatial-frequency domain imaging (SFDI), as a noncontact, low-cost and wide-field optical imaging technique, offers great potential for agro-product safety and quality assessment through optical absorption (μa) and scattering (μ) property measurements. In this study, a laboratory-based SFDI system was constructed and developed for optical property measurement of fruits and vegetables. The system utilized a digital light projector to generate structured, periodic light patterns and illuminate test samples...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910198/degradation-and-biocompatibility-of-photoembossed-plga-acrylate-blend-for-improved-cell-adhesion
#15
Nanayaa F Hughes-Brittain, Lin Qiu, Wen Wang, Ton Peijs, Cees W M Bastiaansen
We have shown previously that PMMA-acrylate photopolymers are biocomopatible and can exhibit improved cell adhesion compared to PMMA, due to an increase in negative surface charge caused by UV radiation PLGA has been used widely in soft tissue regeneration due to its high biocompatibility and cell adhesion. This polymer is also biodegradable and can be utilised in the field of vascular regeneration. In this study, PLGA is blended with a triacrylate monomer (TPETA) to create a degradable photopolymer blend. Surface relief structures are formed on this PLGA-TPETA by photoembossing...
December 2, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27909441/apple-f-box-protein-mdmax2-regulates-plant-photomorphogenesis-and-stress-response
#16
Jian-Ping An, Rui Li, Feng-Jia Qu, Chun-Xiang You, Xiao-Fei Wang, Yu-Jin Hao
MAX2 (MORE AXILLARY GROWTH2) is involved in diverse physiological processes, including photomorphogenesis, the abiotic stress response, as well as karrikin and strigolactone signaling-mediated shoot branching. In this study, MdMAX2, an F-box protein that is a homolog of Arabidopsis MAX2, was identified and characterized. Overexpression of MdMAX2 in apple calli enhanced the accumulation of anthocyanin. Ectopic expression of MdMAX2 in Arabidopsis exhibited photomorphogenesis phenotypes, including increased anthocyanin content and decreased hypocotyl length...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27908097/molecular-dynamics-analysis-of-the-effect-of-electronic-polarization-on-the-structure-and-single-particle-dynamics-of-mixtures-of-ionic-liquids-and-lithium-salts
#17
Volker Lesch, Hadrián Montes-Campos, Trinidad Méndez-Morales, Luis Javier Gallego, Andreas Heuer, Christian Schröder, Luis M Varela
We report a molecular dynamics study on the effect of electronic polarization on the structure and single-particle dynamics of mixtures of the aprotic ionic liquid 1-ethyl-3-methylimidazolium bis-(trifluoromethylsulfonyl)-imide ([EMIM][TFSI]) doped with a lithium salt with the same anion at 298 K and 1 bar. In particular, we analyze the effect of electron density fluctuations on radial distribution functions, velocity autocorrelation functions, cage correlation functions, mean-squared displacements, and vibrational densities of states, comparing the predictions of the quantum-chemistry-based Atomistic Polarizable Potential for Liquids, Electrolytes, & Polymers (APPLE&P) with those of its nonpolarizable version and those of the standard non-polarizable Optimized Potentials for Liquid Simulations-All Atom (OPLS-AA)...
November 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27908063/simulation-study-of-axial-ultrasonic-wave-propagation-in-heterogeneous-bovine-cortical-bone
#18
Toshiho Hata, Yoshiki Nagatani, Koki Takano, Mami Matsukawa
The effect of the heterogeneity of the long cortical bone is an important factor when applying the axial transmission technique. In this study, the axial longitudinal wave velocity distributions in specimens from the mid-shaft of a bovine femur were measured, in the MHz range. Bilinear interpolation and the piecewise cubic Hermite interpolating polynomial method were used to construct three-dimensional (3D) axial velocity models with a resolution of 40 μm. By assuming the uniaxial anisotropy of the bone and using the results of previous experimental studies [Yamato, Matsukawa, Yanagitani, Yamazaki, Mizukawa, and Nagano (2008b)...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27907081/how-to-plant-apple-trees-to-reduce-replant-disease-in-apple-orchard-a-study-on-the-phenolic-acid-of-the-replanted-apple-orchard
#19
Chengmiao Yin, Li Xiang, Gongshuai Wang, Yanfang Wang, Xiang Shen, Xuesen Chen, Zhiquan Mao
Apple replant disease (ARD) is an important problem in the production of apple. The phenolic acid is one of the causes of ARD. How phenolic acid affects the ARD was not well known. In this study, we analyzed the type, concentration and annual dynamic variation of phenolic acid in soil from three replanted apple orchards using an accelerated solvent extraction system with high performance liquid chromatography (ASE-HPLC). We found that the type and concentration of phenolic acid were significantly differed among different seasons, different sampling positions and different soil layers...
2016: PloS One
https://www.readbyqxmd.com/read/27906139/myxobacteria-mediated-synthesis-of-silver-nanoparticles-and-their-impregnation-in-wrapping-paper-used-for-enhancing-shelf-life-of-apples
#20
Swati Bhople, Swapnil Gaikwad, Swapna Deshmukh, Shital Bonde, Aniket Gade, Sanjib Sen, Anna Brezinska, Hanna Dahm, Mahendra Rai
The authors report Myxobacteria virescens (M. virescens) mediated synthesis of silver nanoparticles (AgNPs) and its efficacy against Staphylococcus aureus (ATCC-33591), Salmonella typhi (ATCC-51812), Escherichia coli (E. coli) (ATCC-14948), Klebsiella pneumoniae (MTCC-4030) and Pseudomonas aeruginosa (MTCC-4673). The organism exhibiting resistance to various antibiotics showed remarkable sensitivity, when used in combination of antibiotics and AgNPs. Antimicrobial property of AgNPs is playing a significant role in medicine and food storage...
December 2016: IET Nanobiotechnology
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