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https://www.readbyqxmd.com/read/28097508/preparation-and-evaluation-of-biopolymeric-nanoparticles-as-drug-delivery-system-in-effective-treatment-of-rheumatoid-arthritis
#1
Vijay Kumar, Ankita Leekha, Aakriti Tyagi, Ankur Kaul, Anil Kumar Mishra, Anita Kamra Verma
PURPOSE: The study purposes to evaluate nanocrystalline biopolymeric nanoparticles encapsulating methotrexate and dexamethasone with high biocompatibility, enhanced therapeutic efficacy and reduced toxicity. METHODS: Chitosan nanoparticles were prepared by ionic gelation, and Methotrexate (MTX) and Dexamethasone (DEX) were loaded during the preparation and screened for their in vitro efficacy in HEK and RAW264.7 cells, ex vivo and in vivo efficacy. RESULTS: FTIR confirmed the involvement of phosphoric group of sTPP with amine groups of chitosan and also role of hydrogen bonding involved in the preparation of MTXCHNP and DEXCHNP...
January 17, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28061024/beyond-the-code-a-guide-to-the-description-and-documentation-of-biodiversity-in-ciliated-protists-alveolata-ciliophora
#2
Alan Warren, David J Patterson, Micah Dunthorn, John C Clamp, Undine E M Achilles-Day, Erna Aescht, Saleh A Al-Farraj, Saleh Al-Quraishy, Khaled Al-Rasheid, Martin Carr, John G Day, Marc Dellinger, Hamed A El-Serehy, Yangbo Fan, Feng Gao, Shan Gao, Jun Gong, Renu Gupta, Xiaozhong Hu, Komal Kamra, Gaytha Langlois, Xiaofeng Lin, Diana Lipscomb, Christopher S Lobban, Pierangelo Luporini, Denis H Lynn, Honggang Ma, Miroslav Macek, Jacqueline Mackenzie-Dodds, Seema Makhija, Robert I Mansergh, Mercedes Martín-Cereceda, Nettie McMiller, David J S Montagnes, Nikolaeva Svetlana, Geoffrey Odhiambo Ong'ondo, Blanca Pérez-Uz, Jasmine Purushothaman, Pablo Quintela-Alonso, Johana Rotterová, Luciana Santoferrara, Chen Shao, Zhuo Shen, Xinlu Shi, Weibo Song, Thorsten Stoeck, Antonietta La Terza, Adriana Vallesi, Mei Wang, Thomas Weisse, Krzysztof Wiackowski, Lei Wu, Kuidong Xu, Zhenzhen Yi, Rebecca Zufall, Sabine Agatha
Recent advances in molecular technology have revolutionized research on all aspects of the biology of organisms, including ciliates, and created unprecedented opportunities for pursuing a more integrative approach to investigation of biodiversity. However, this goal is complicated by large gaps and inconsistencies that still exist in the foundation of basic information about biodiversity of ciliates. The present paper reviews issues relating to the taxonomy of ciliates and presents specific recommendations for best practice in the observation and documentation of their biodiversity...
January 6, 2017: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/28052762/indirect-treatment-comparison-of-dabrafenib-plus-trametinib-versus-vemurafenib-plus-cobimetinib-in-previously-untreated-metastatic-melanoma-patients
#3
Adil Daud, Japinder Gill, Sheily Kamra, Lei Chen, Amit Ahuja
BACKGROUND: Metastatic melanoma is an aggressive form of skin cancer with a high mortality rate and the fastest growing global incidence rate of all malignancies. The introduction of BRAF/MEK inhibitor combinations has yielded significant increases in PFS and OS for melanoma. However, at present, no direct comparisons between different BRAF/MEK combinations have been conducted. In light of this, an indirect treatment comparison was performed between two BRAF/MEK inhibitor combination therapies for metastatic melanoma, dabrafenib plus trametinib and vemurafenib plus cobimetinib, in order to understand the relative efficacy and toxicity profiles of these therapies...
January 4, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/27994430/nonsurgical-endodontic-therapy-along-with-minimal-invasive-treatment-utilizing-bhasker-s-hypothesis-for-the-management-of-infected-radicular-cystic-lesion-a-rare-case-report
#4
Sanjeev Kumar Salaria, Shilpa Kamra, Simrat Kaur Ghuman, Garima Sharma
Radicular cyst (RC) is the most common odontogenic cyst of inflammatory origin affecting the jaws; involves the roots of the carious or traumatic non-vital tooth. Different therapeutic modalities, such as nonsurgical endodontic therapy or surgical enucleation with primary closure, decompression etc., were proposed for the management of such lesions. Presenting a case of a 28-year-old otherwise healthy male patient who reported with pain and swelling with respect to tooth #41, 31. Diagnosis of infected RC at a rare location was established on the basis of clinical, radiographical and fine needle aspiration cytological examination...
October 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27972198/a-systematic-literature-review-to-identify-clinical-drivers-in-cost-effectiveness-analyses-in-t2dm-patients-uncontrolled-on-current-therapies
#5
M Afonso, J Gupta, S Kamra, J Jasso-Mosqueda
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27970568/extrapolation-with-patient-level-time-to-event-data-in-various-disease-areas-a-review-of-current-recommendations-and-gaps
#6
S Kamra, J Kaur, J Kartheek, M Sehgal, M K Siddiqui
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27956824/short-term-visual-result-after-simultaneous-photorefractive-keratectomy-and-small-aperture-cornea-inlay-implantation
#7
Majid Moshirfar, Ryan T Wallace, David F Skanchy, Jordan D Desautels, Steven H Linn, Phillip C Hoopes, Daniel S Durrie
PURPOSE: To report the short-term results of simultaneous photorefractive keratectomy (PRK) and small-aperture cornea inlay implantation (KAMRA) surgery in treating presbyopia. METHODS: Simultaneous PRK and KAMRA inlay surgery was performed on 21 patients from July 2015 to March 2016. Follow-up exams were conducted at 1, 3, and 6 months postoperatively. Our patients were also divided preoperatively into three categories: myopic, hyperopic, and emmetropic. Over the 6-month period, the main outcome measures were uncorrected near visual acuity (UNVA), changes in best-corrected distance visual acuity, and mean spherical equivalent refraction...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27843289/six-month-visual-outcomes-for-the-correction-of-presbyopia-using-a-small-aperture-corneal-inlay-single-site-experience
#8
Majid Moshirfar, Tyler S Quist, David F Skanchy, Ryan T Wallace, Steven H Linn, Phillip C Hoopes
OBJECTIVE: The objective of this study was to describe 6-month postoperative efficacy and safety outcomes after monocular KAMRA corneal inlay implantation in emmetropic presbyopic patients. STUDY DESIGN: This study followed a retrospective chart analysis. SETTING: This study was performed at Hoopes Vision in Draper, UT, USA. SUBJECTS AND METHODS: Fifty-seven patients met the inclusion criteria of this study and underwent KAMRA corneal inlay implantation following the approval of the United States Food and Drug Association between May 2015 and April 2016 at a single site...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27833492/submandibular-intubation-in-awake-patient-of-panfacial-trauma
#9
S K Kamra, H K Khandavilli, P Banerjee
Maxillofacial trauma patients present with airway problems. Submandibular intubation is an effective means of intubation to avoid tracheostomy for operative procedures. Airway is secured with oral endotracheal intubation in paralyzed patient and tube is then transplaced in sub mental or submandibular region. However there may be instances when paralyzing such trauma patients is not safe and short term tracheostomy is the only airway channel available for conduction of anesthesia. We report a case of submandibular intubation in awake patient of maxillofacial trauma with anticipated intubation problems...
October 2016: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/27722621/a-modular-approach-for-assembling-turn-on-fluorescence-sensors-using-molecularly-imprinted-nanoparticles
#10
Qianjin Li, Tripta Kamra, Lei Ye
Combining straightforward molecular imprinting with orthogonal click chemistry and accessible fluorescent dyes, a modular approach has been developed to assemble turn-on optical sensors based on fluorescence resonance energy transfer in molecularly imprinted nanoparticles.
October 6, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27631415/-the-kamra%C3%A2-inlay-a%C3%A2-realistic-approach
#11
M El-Husseiny, L Daas, A Viestenz, A Langenbucher, B Seitz
BACKGROUND AND PURPOSE: The KAMRA™ inlay (AcuFocus, Irvine, California, USA) is an additional option for correcting presbyopia that has been used for many years in refractive surgery. Our objective is to report our three-month postoperative results of KAMRA™ inlay implantation in terms of near, intermediate and distance vision. PATIENTS AND METHODS: All 24 patients (average age 54.1 ± 6.0 years) were treated with the KAMRA™ inlay in the non-dominant eye (75 % in the left eye) by the same surgeon (MEH)...
September 8, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27610214/draft-genome-sequence-of-lampropedia-cohaerens-strain-ct6-t-isolated-from-arsenic-rich-microbial-mats-of-a-himalayan-hot-water-spring
#12
Charu Tripathi, Nitish K Mahato, Pooja Rani, Yogendra Singh, Komal Kamra, Rup Lal
Lampropedia cohaerens strain CT6(T), a non-motile, aerobic and coccoid strain was isolated from arsenic rich microbial mats (temperature ~45 °C) of a hot water spring located atop the Himalayan ranges at Manikaran, India. The present study reports the first genome sequence of type strain CT6(T) of genus Lampropedia cohaerens. Sequencing data was generated using the Illumina HiSeq 2000 platform and assembled with ABySS v 1.3.5. The 3,158,922 bp genome was assembled into 41 contigs with a mean GC content of 63...
2016: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/27604686/novel-oligopyrrole-carboxamide-based-nickel-ii-and-palladium-ii-salens-their-targeting-of-human-g-quadruplex-dna-and-selective-cancer-cell-toxicity
#13
Asfa Ali, Mohini Kamra, Soma Roy, K Muniyappa, Santanu Bhattacharya
DNA targeting by various metal complexes is a key strategy toward the restriction of cancer cell proliferation. Toward this end, we designed and synthesized novel salen-based Ni(II) and Pd(II) metal complexes with positively charged flanking side chains comprising N-methylpyrrole carboxamides of varying lengths. The compounds showed high specificity toward G-quadruplex DNA over duplex DNA. Sufficient inhibition of the telomerase activity was observed, which was ascertained by the prominent restriction of cancer cell proliferation in the long-term cell viability and telomerase inhibition assays...
September 20, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27536919/bimaxillary-oral-focal-mucinosis
#14
Sunil Yadav, Sunita Malik, Hitesh Chander Mittal, Gurdarshan Singh, Hemlata Kamra
Oral focal mucinosis is considered as oral counterpart of cutaneous focal mucinosis. The preoperative diagnosis of mucinosis is almost impossible because of its rarity and clinical similarity to other lesions of various etiologies. The histological diagnosis of oral mucinosis is important to better understand the etiopathogenesis, treatment modalities, and any recurrence of the lesion besides differentiating from the other soft tissue lesions.The purpose of this paper is to report the first case of bimaxillary involvement with dome-shaped elevated, rounded, asymptomatic, normally colored swelling in left posterior palatal mucosa and left mandibular posterior region in a 25-year old woman who was diagnosed as oral focal mucinosis histopathologically...
October 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27472092/increased-cd40-ligation-and-reduced-bcr-signalling-leads-to-higher-il-10-production-in-b-cells-from-tolerant-kidney-transplant-patients
#15
Estefania Nova-Lamperti, Prabhjoat Chana, Paula Mobillo, Manohursingh Runglall, Yogesh Kamra, Reuben McGregor, Graham M Lord, Robert I Lechler, Giovanna Lombardi, Maria P Hernandez-Fuentes
BACKGROUND: An increased percentage of peripheral transitional B cells producing IL-10 has been observed in patients tolerant to kidney allografts. In healthy volunteers, the balance between the CD40 and B cell receptor (BCR) signalling modulated IL-10 production by B cells, with stimulation via the BCR decreasing CD40-mediated-IL-10 production. In this study, we evaluate whether in tolerant kidney transplant patients the increased IL-10 production by B cells was due to an altered CD40 and/or BCR signalling...
July 28, 2016: Transplantation
https://www.readbyqxmd.com/read/27465694/effect-of-feeding-tannin-degrading-bacteria-streptococcus-gallolyticus-strain-tdgb-406-on-meat-quality-of-goats-fed-with-quercus-semicarpifolia-leaves
#16
Kaushalendra Kumar, L C Chaudhary, Neeta Agarwal, D N Kamra
The effect of feeding tannin-degrading bacteria (Streptococcus gallolyticus strain TDGB 406) on carcass characteristics of goats fed with oak (Quercus semicarpifolia) leaves was studied on 18 male goats (4 months old, average body weight 9.50 ± 1.50 kg), distributed into three groups of six animals each. The animals of group 1 served as control, while the animals of groups 2 and 3 were given (at 5 ml/kg live weight) autoclaved and live culture of isolate TDGB 406 (10(6) cells/ml), respectively. The animals were fed with oak leaves as a basal roughage source and maize hay along with fixed quantity of concentrate mixture...
October 2016: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27328267/biomarkers-of-tolerance-in-kidney-transplantation-are-we-predicting-tolerance-or-response-to-immunosuppressive-treatment
#17
I Rebollo-Mesa, E Nova-Lamperti, P Mobillo, M Runglall, S Christakoudi, S Norris, N Smallcombe, Y Kamra, R Hilton, S Bhandari, R Baker, D Berglund, S Carr, D Game, S Griffin, P A Kalra, R Lewis, P B Mark, S Marks, I Macphee, W McKane, M G Mohaupt, R Pararajasingam, S P Kon, D Serón, M D Sinha, B Tucker, O Viklický, R I Lechler, G M Lord, M P Hernandez-Fuentes
We and others have previously described signatures of tolerance in kidney transplantation showing the differential expression of B cell-related genes and the relative expansions of B cell subsets. However, in all of these studies, the index group-namely, the tolerant recipients-were not receiving immunosuppression (IS) treatment, unlike the rest of the comparator groups. We aimed to assess the confounding effect of these regimens and develop a novel IS-independent signature of tolerance. Analyzing gene expression in three independent kidney transplant patient cohorts (232 recipients and 14 tolerant patients), we have established that the expression of the previously reported signature was biased by IS regimens, which also influenced transitional B cells...
June 21, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27304602/contrast-sensitivity-in-patients-with-emmetropic-presbyopia-before-and-after-small-aperture-inlay-implantation
#18
Ling Lin, Corina van de Pol, Srividhya Vilupuru, Jay S Pepose
PURPOSE: To develop a normative contrast sensitivity function and examine the postoperative contrast sensitivity outcomes for emmetropic patients with presbyopia implanted with a KAMRA intracorneal inlay (AcuFocus Inc., Irvine, CA) in their non-dominant eyes. METHODS: A prospective, non-randomized, multicenter clinical trial was conducted on 507 patients between 45 and 60 years of age who were monocularly implanted with the KAMRA inlay. A predetermined subgroup of 335 patients in the contrast sensitivity substudy were measured preoperatively and postoperatively with the Functional Acuity Contrast Test (FACT) chart in the Optec 6500 Vision Tester (Stereo Optical Co...
June 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27304601/long-term-results-of-combined-lasik-and-monocular-small-aperture-corneal-inlay-implantation
#19
Estera Igras, Rónán O'Caoimh, Paul O'Brien, William Power
PURPOSE: To evaluate the long-term effectiveness and safety of combined LASIK and small-aperture intracorneal inlay implantation (KAMRA; AcuFocus, Irvine, CA) for the surgical compensation of presbyopia and refractive errors. METHODS: Retrospective chart review of all ametropic, presbyopic patients who underwent combined LASIK and KAMRA inlay implantation at a single clinic. Demographic data and preoperative uncorrected and corrected monocular and binocular near and distance visual acuity (UNVA, UDVA, and CDVA) with manifest refractive spherical equivalent (MRSE) were collected and analyzed...
June 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27274194/clinical-utility-of-the-kamra-corneal-inlay
#20
REVIEW
Shehzad Anjam Naroo, Paramdeep Singh Bilkhu
The treatment of presbyopia has been the focus of much scientific and clinical research over recent years, not least due to an increasingly aging population but also the desire for spectacle independence. Many lens and nonlens-based approaches have been investigated, and with advances in biomaterials and improved surgical methods, removable corneal inlays have been developed. One such development is the KAMRA™ inlay where a small entrance pupil is exploited to create a pinhole-type effect that increases the depth of focus and enables improvement in near visual acuity...
2016: Clinical Ophthalmology
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