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https://www.readbyqxmd.com/read/28708710/bone-accrual-in-children-and-adolescent-nonelite-swimmers-a-2-year-longitudinal-study
#1
Andy C Collins, Kenneth D Ward, Barbara S McClanahan, Deborah L Slawson, Christopher Vukadinovich, Kamra E Mays, Nancy Wilson, George Relyea
OBJECTIVE: To examine differences in bone mass between children and adolescents swimming competitively at nonelite levels (locally and regionally) and nonathletes and to assess changes in bone mass in these 2 groups over 24 months after taking into consideration several known confounders of bone mass. DESIGN: Observational prospective study. PARTICIPANTS: White nonelite swimmers (n = 128) and nonathletes (n = 106) 8 to 18 years of age from Memphis, Tennessee, USA...
July 11, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28680206/avascular-necrosis-of-talus-diagnosed-on-tc-99m-mdp-bone-scan
#2
Ashish R Kamra, Shwetal U Pawar, Suruchi Shetye, Preeti R Singh
Avascular necrosis (AVN) of bone is defined as the cellular death of bone components due to the interruption of the blood supply; the bone structures then collapse, resulting in pain and loss of joint function. Magnetic resonance imaging (MRI) is the gold standard to diagnose AVN. We present an unusual case of AVN of talus in a patient of thalassemia major that was diagnosed on the Tc-99m MDP bone scan with equivocal findings on MRI. Key Message: The diagnosis of AVN is primarily done using radiological investigations...
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28638096/identification-of-a-flavonoid-isolated-from-plum-prunus-domestica-as-a-potent-inhibitor-of-hepatitis-c-virus-entry
#3
Mihika Bose, Mohini Kamra, Ranajoy Mullick, Santanu Bhattacharya, Saumitra Das, Anjali A Karande
Hepatitis C virus (HCV) infection is a major cause of chronic liver diseases that often requires liver transplantation. The standard therapies are limited by severe side effects, resistance development, high expense and in a substantial proportion of cases, fail to clear the infection which bespeak the need for development of well-tolerated antivirals. Since most of the drug development strategies target the replication stage of viral lifecycle, the identification of entry inhibitors might be crucial especially in case of liver-transplant recipients...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28624500/phoenixin-14-concentrations-are-increased-in-association-with-luteinizing-hormone-and-nesfatin-1-concentrations-in-women-with-polycystic-ovary-syndrome
#4
Kamran Ullah, Tanzil Ur Rahman, Dan-Dan Wu, Xian-Hua Lin, Ye Liu, Xiao-Yan Guo, Peter C K Leung, Run-Ju Zhang, He-Feng Huang, Jian-Zhong Sheng
BACKGROUND: Polycystic ovary syndrome (PCOS) is commonly characterized by obesity, insulin resistance (IR), hyperandrogenemia and hirsutism. Following the reported relationship between phoenixin-14 and gonadotropin production in rat hypothalamic-pituitary-gonadal axis, the present study was designed to investigate the circulating concentrations of phoenixin-14 and their associations with the concentrations of sex hormones including luteinizing hormone (LH), follicular stimulating hormone (FSH), estradiol (E2), progesterone (P4) and total testosterone (TT) in PCOS patients...
June 15, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28611492/genome-mining-and-predictive-functional-profiling-of-acidophilic-rhizobacterium-pseudomonas-fluorescens-pt14
#5
Pooja Rani, Nitish Kumar Mahato, Anukriti Sharma, Desiraju Lakshmi Narsimha Rao, Komal Kamra, Rup Lal
Pseudomonas fluorescens Pt14 is a non-pathogenic and acidophilic bacterium isolated from acidic soil (pH 4.65). Genome sequencing of strain Pt14 was performed using Single Molecule Real Time (SMRT) sequencing to get insights into unique existence of this strain in acidic environment. Complete genome sequence of this strain revealed a chromosome of 5,841,722 bp having 5354 CDSs and 88 RNAs. Phylogenomic reconstruction based on 16S rRNA gene, Average Nucleotide Identity (ANI) values and marker proteins revealed that strain Pt14 shared a common clade with P...
June 2017: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/28607884/rigid-bronchoscopic-placement-of-fogarty-catheter-as-a-bronchial-blocker-for-one-lung-isolation-and-ventilation-in-infants-and-children-undergoing-thoracic-surgery-a-single-institution-experience-of-27-cases
#6
Sunil Kant Kamra, Ashwin Ashok Jaiswal, Amrish Kumar Garg, Manoj Kumar Mohanty
One-lung ventilation (OLV) is a challenging task in infants and children as few techniques are possible because of narrow anatomy. The aim of this study is to evaluate and experience lung isolation with Fogarty catheters as a bronchial blocker placed by rigid bronchoscope for OLV in infants and children with lung pathologies requiring surgical management in an industrial hospital. This study is a prospective study carried out in J.L.N. Hospital and Research Centre, Bhilai (CG), from January 2011 to December 2014...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28602335/neodymium-yag-laser-posterior-capsulotomy-in-eye-with-an-intrastromal-inlay
#7
Phillip C Hoopes, Jordan D Desautels, Majid Moshirfar, Steven H Linn, Nick Mamalis
We report intraoperative issues, patient outcomes, and lessons learned from inadvertently contacting a Kamra corneal inlay with a neodymium:YAG (Nd:YAG) laser during a routine capsulotomy procedure for posterior capsule opacification. We also present scanning electron microscopic and histopathologic images from a series of 4 inlays implanted in postmortem porcine eyes that were purposely contacted with an Nd:YAG laser. Our capsulotomy patient developed a clinically insignificant and transient corneal opacity accompanied by mild blanching on the inlay...
May 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28532945/sequential-pars-plana-vitrectomy-and-cataract-extraction-with-intraocular-lens-implantation-in-patient-with-corneal-inlay-who%C3%A2-developed-retinal-detachment-followed%C3%A2-by%C3%A2-cataract
#8
Nada S Jabbur, Shady T Awwad, Ziad F Bashshur
Twenty-one months after successful small-aperture corneal inlay (Kamra) implantation simultaneous with myopic laser in situ keratomileusis, a patient presented with a superior rhegmatogenous macula-involving retinal detachment. Successful pars plana vitrectomy, transscleral cryotherapy, and gas tamponade were performed with the inlay in situ. Three months later, uneventful phacoemulsification and posterior chamber intraocular lens implantation were performed, also with the inlay in situ, for a visually significant cataract...
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28511384/community-acquired-burkholderia-cepacia-bacteraemia-presenting-as-mods-in-an-immunocompetent-individual-an-unusual-case
#9
Ritesh Ranjan, Priti Chowdhary, Aman Kamra
Burkholderia cepacia has been recognized as a group of highly virulent organisms known as Burkholderia cepacia complex (Bcc). Bcc are ubiquitous in nature and most commonly found in moist environment, on plant roots and soil. Because of its high intrinsic antibiotic resistance, Bcc is a major cause of morbidity and mortality in hospitalized patients. It is reported most commonly in immunocompromised patients especially in patients with cystic fibrosis. Here, we report a rare case report of bacteraemia by Burkholderia cepacia in an immunocompetent male, who presented with fever and Multiple Organ Dysfunction Syndrome (MODS)...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28444515/cataract-surgery-in-patients-with-a-previous-history-of-kamra-inlay-implantation-a-case-series
#10
Majid Moshirfar, Tyler S Quist, David F Skanchy, Steven H Linn, Jordan Desautels, Phillip C Hoopes
INTRODUCTION: The visual outcome of cataract surgery in patients with a previous history of KAMRA inlay implantation is an emerging issue for which limited research exists. The purpose of this study is to describe postoperative visual outcomes in this patient population. METHODS: This is a case series with retrospective chart review. Seven patients underwent cataract surgery following KAMRA corneal inlay implantation. Visual acuity was assessed before and after cataract surgery...
June 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28390052/a-review-of-presbyopia-treatment-with-corneal-inlays
#11
REVIEW
M Amir Moarefi, Shamik Bafna, William Wiley
The prevalence of presbyopia continues to increase every year. The therapeutic approaches to presbyopia cover the spectrum of non-surgical to surgical techniques. With recent advances in biocompatible materials, corneal inlays make a strong case for their place within the treatment spectrum. This article takes a closer look at three of the current corneal inlay models: KAMRA, Raindrop, and Presbia Flexivue Microlens. Each design approach and mode of action is described with data from key clinical trials. Furthermore, the ability to choose the most suitable corneal inlay is presented by comparing each model and identifying their similarities and differences...
June 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28359626/effects-of-femtosecond-and-excimer-lasers-on-implanted-kamra-corneal-inlay-in-animal-models
#12
F K Sammouh, T A Baban, W N Dandan, E L Warrak
PURPOSE: To evaluate the effect of femtosecond laser and excimer laser on an intracorneal inlay (KAMRA(®)) implanted in animal models. METHODS: Femtosecond laser was used to create corneal intrastromal pockets at 250μm depth in five porcine eyes. Four intact KAMRA inlays, examined by slit-lamp biomicroscopy and light microscopy, were implanted in the pocket of four eyes. A standard LASIK flap was created above each implanted inlay in the four eyes using a femtosecond laser with flap thicknesses of 150μm, 130μm, 110μm and 90μm...
May 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28329227/incident-cardiovascular-events-and-death-in-individuals-with-restless-legs-syndrome-or-periodic-limb-movements-in-sleep-a-systematic-review
#13
REVIEW
Tetyana Kendzerska, Maneesha Kamra, Brian J Murray, Mark I Boulos
Study Objectives: To systematically review the current evidence examining restless legs syndrome (RLS) and periodic limb movements in sleep (PLMS) as prognostic factors for all-cause mortality and incident cardiovascular events (CVE) in longitudinal studies published in the adult population. Methods: All English language studies (from 1947 to 2016) found through Medline and Embase, as well as bibliographies of identified articles, were considered eligible. Quality was evaluated using published guidelines...
March 1, 2017: Sleep
https://www.readbyqxmd.com/read/28231698/effect-of-feeding-of-blend-of-essential-oils-on-methane-production-growth-nutrient-utilization-in-growing-buffaloes
#14
M A Yatoo, L C Chaudhary, Neeta Agarwal, V B Chaturvedi, D N Kamra
Objective: An experiment was conducted to study the effect of a blend of essential oils (BEO) on enteric methane emission and growth performance of buffaloes (Bubalus bubalis). Methods: Twenty one growing male buffaloes (average body weight of 279 ± 9.3 kg) were divided in to three groups. The animals of all the three groups were fed on a ration consisting of wheat straw and concentrate mixture targeting 500g daily live weight gain. The three dietary groups were; Group1: control without additive, Group 2 and 3: supplemented with BEO @ 0...
February 23, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28207851/impact-of-levels-of-total-digestible-nutrients-on-microbiome-enzyme-profile-and-degradation-of-feeds-in-buffalo-rumen
#15
Anju Kala, D N Kamra, Avinash Kumar, Neeta Agarwal, L C Chaudhary, C G Joshi
The present study was aimed at understanding a shift in rumen microbiome of buffaloes fed various levels of total digestible nutrients. To understand the process, the metagenomics of rumen microbes, in vivo and in vitro rumen fermentation studies were carried out. Three rumen fistulated adult male Murrah buffaloes were fed three isonitrogenous diets varying in total digestible nutrients (70, 85 and 100% of TDN requirement) in 3X3 switch over design. On dry matter basis, wheat straw/ roughage content were 81, 63 and 51% and that of maize grain was 8, 16 and 21% in three diets respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28182145/stereoacuity-after-small-aperture-corneal-inlay-implantation
#16
Steven H Linn, David F Skanchy, Tyler S Quist, Jordan D Desautels, Majid Moshirfar
PURPOSE: The aim of this study was to compare stereoacuity before and after KAMRA corneal inlay implantation for the correction of presbyopia. PATIENTS AND METHODS: This is a prospective study of 60 patients who underwent KAMRA inlay implantation. Patients were examined before and 6 months after surgery for stereoacuity, uncorrected distance visual acuity (UDVA), and uncorrected near visual acuity (UNVA). RESULTS: The mean stereoacuity before surgery was 29...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28165710/enhanced-g-quadruplex-dna-stabilization-and-telomerase-inhibition-by-novel-fluorescein-derived-salen-and-salphen-based-ni-ii-and-pd-ii-complexes
#17
Asfa Ali, Mohini Kamra, Soma Roy, K Muniyappa, Santanu Bhattacharya
Metal based salen complexes have been considered as an important scaffold toward targeting of DNA structures. In the present work, we have synthesized nickel(II) and palladium(II) salen and salphen complexes by using readily available fluorescein as the backbone to provide an extended aromatic surface. The metal complexes exhibit affinity toward the human telomeric G-quadruplex DNA with promising inhibition of telomerase activity. This has been ascertained by their efficiency in the long term cell proliferation assay which showed significant cancer cell toxicity in the presence of the metal complexes...
February 15, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28097508/preparation-and-evaluation-of-biopolymeric-nanoparticles-as-drug-delivery-system-in-effective-treatment-of-rheumatoid-arthritis
#18
Vijay Kumar, Ankita Leekha, Aakriti Tyagi, Ankur Kaul, Anil Kumar Mishra, Anita Kamra Verma
PURPOSE: The study purposes to evaluate nanocrystalline biopolymeric nanoparticles encapsulating methotrexate and dexamethasone with high biocompatibility, enhanced therapeutic efficacy and reduced toxicity. METHODS: Chitosan nanoparticles were prepared by ionic gelation, and Methotrexate (MTX) and Dexamethasone (DEX) were loaded during the preparation and screened for their in vitro efficacy in HEK and RAW264.7 cells, ex vivo and in vivo efficacy. RESULTS: FTIR confirmed the involvement of phosphoric group of sTPP with amine groups of chitosan and also role of hydrogen bonding involved in the preparation of MTXCHNP and DEXCHNP...
January 17, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28061024/beyond-the-code-a-guide-to-the-description-and-documentation-of-biodiversity-in-ciliated-protists-alveolata-ciliophora
#19
Alan Warren, David J Patterson, Micah Dunthorn, John C Clamp, Undine E M Achilles-Day, Erna Aescht, Saleh A Al-Farraj, Saleh Al-Quraishy, Khaled Al-Rasheid, Martin Carr, John G Day, Marc Dellinger, Hamed A El-Serehy, Yangbo Fan, Feng Gao, Shan Gao, Jun Gong, Renu Gupta, Xiaozhong Hu, Komal Kamra, Gaytha Langlois, Xiaofeng Lin, Diana Lipscomb, Christopher S Lobban, Pierangelo Luporini, Denis H Lynn, Honggang Ma, Miroslav Macek, Jacqueline Mackenzie-Dodds, Seema Makhija, Robert I Mansergh, Mercedes Martín-Cereceda, Nettie McMiller, David J S Montagnes, Svetlana Nikolaeva, Geoffrey Odhiambo Ong'ondo, Blanca Pérez-Uz, Jasmine Purushothaman, Pablo Quintela-Alonso, Johana Rotterová, Luciana Santoferrara, Chen Shao, Zhuo Shen, Xinlu Shi, Weibo Song, Thorsten Stoeck, Antonietta La Terza, Adriana Vallesi, Mei Wang, Thomas Weisse, Krzysztof Wiackowski, Lei Wu, Kuidong Xu, Zhenzhen Yi, Rebecca Zufall, Sabine Agatha
Recent advances in molecular technology have revolutionized research on all aspects of the biology of organisms, including ciliates, and created unprecedented opportunities for pursuing a more integrative approach to investigations of biodiversity. However, this goal is complicated by large gaps and inconsistencies that still exist in the foundation of basic information about biodiversity of ciliates. The present paper reviews issues relating to the taxonomy of ciliates and presents specific recommendations for best practice in the observation and documentation of their biodiversity...
January 6, 2017: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/28052762/indirect-treatment-comparison-of-dabrafenib-plus-trametinib-versus-vemurafenib-plus-cobimetinib-in-previously-untreated-metastatic-melanoma-patients
#20
Adil Daud, Japinder Gill, Sheily Kamra, Lei Chen, Amit Ahuja
BACKGROUND: Metastatic melanoma is an aggressive form of skin cancer with a high mortality rate and the fastest growing global incidence rate of all malignancies. The introduction of BRAF/MEK inhibitor combinations has yielded significant increases in PFS and OS for melanoma. However, at present, no direct comparisons between different BRAF/MEK combinations have been conducted. In light of this, an indirect treatment comparison was performed between two BRAF/MEK inhibitor combination therapies for metastatic melanoma, dabrafenib plus trametinib and vemurafenib plus cobimetinib, in order to understand the relative efficacy and toxicity profiles of these therapies...
January 4, 2017: Journal of Hematology & Oncology
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