keyword
MENU ▼
Read by QxMD icon Read
search

Organophosphate

keyword
https://www.readbyqxmd.com/read/28930602/molecular-biology-of-tick-acetylcholinesterases
#1
Kevin Bruce Temeyer
Ticks vector many pathogens with major health and economic impacts and have developed resistance to most acaricides used for tick control. Organophosphate (OP) acaricides target acetylcholinesterase (AChE) critical to tick central nervous system function. Mutations producing tick AChEs resistant to OPs were characterized; but tick OP-resistance is not fully elucidated, due to remarkable complexity of tick cholinergic systems. Three paralogous tick AChEs exhibiting differences in primary structure and biochemical kinetics are encoded by amplified genes with developmentally regulated expression...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930579/using-comparative-genomics-to-decode-the-genetics-of-acaricide-resistance
#2
Janice P Van Zee, Catherine A Hill
The availability of genome assemblies and other genomic resources is facilitating investigations of complex genetic traits for several species of ticks. Understanding the genetics of acaricide resistance is a priority for tick and tick-borne disease control. The synaptic enzyme acetylcholinesterase (ACE) is recognized as the target of organophosphates (OPs) and carbamates, and mutations in ACE have been tied to resistance. Multiple studies support three ACE (ace) loci in R. microplus but the molecular basis of OP-resistance in this tick remains elusive...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930298/comparison-of-questionnaire-based-estimation-of-pesticide-residue-intake-from-fruits-and-vegetables-with-urinary-concentrations-of-pesticide-biomarkers
#3
Yu-Han Chiu, Paige L Williams, Lidia Mínguez-Alarcón, Matthew Gillman, Qi Sun, Maria Ospina, Antonia M Calafat, Russ Hauser, Jorge E Chavarro
We developed a pesticide residue burden score (PRBS) based on a food frequency questionnaire and surveillance data on food pesticide residues to characterize dietary exposure over the past year. In the present study, we evaluated the association of the PRBS with urinary concentrations of pesticide biomarkers. Fruit and vegetable (FV) intake was classified as having high (PRBS≥4) or low (PRBS<4) pesticide residues for 90 men from the EARTH study. Two urine samples per man were analyzed for seven biomarkers of organophosphate and pyrethroid insecticides, and the herbicide 2,4-dichlorophenoxyacetic acid...
September 20, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28929966/-a-case-with-scalp-pruritus-caused-by-dermanysus-gallinae-order-mesostigmata
#4
Mustafa Şengül, Nida Kaçar, Mehmet Karaca, Sedef Zeliha Öner, Çağrı Ergin
Dermanyssus gallinae is one of the important hematophagous ectoparasite species of poultry like chicken, pigeon and wild bird species. These ectoparasites in the form of nymphs or adults who can not find their hosts are also seen in mammals and even in humans. For this reason, they are considered as important for public health. The ectoparasite causes a clinical condition named gamasoidosis among pet owners and people who live or work close to animal shelters, barns and chicken farms. Pruritus dermatitis is also caused by D...
July 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28929747/the-structure-of-an-insecticide-sequestering-carboxylesterase-from-the-disease-vector-culex-quinquefasciatus-what-makes-an-enzyme-a-good-insecticide-sponge
#5
Davis Henry Hopkins, Nicholas J Fraser, Peter D Mabbitt, Paul D Carr, John G Oakeshott, Colin J Jackson
Carboxylesterase (CBE)-mediated metabolic resistance to organophosphate and carbamate insecticides is a major problem for the control of insect disease vectors, such as the mosquito. The most common mechanism involves overexpression of CBEs that bind to the insecticide with high affinity, thereby sequestering them before they can interact with their target. However, the absence of any structure for an insecticide-sequestering CBE limits our understanding of the molecular basis for this process. We present the first structure of a CBE involved in sequestration, Cqestβ21, from the mosquito disease vector, Culex quinquefasciatus...
September 20, 2017: Biochemistry
https://www.readbyqxmd.com/read/28927721/agonistic-effects-of-diverse-xenobiotics-on-the-constitutive-androstane-receptor-as-detected-in-a-recombinant-yeast-cell-assay
#6
Ryo Kamata, Daisuke Nakajima, Fujio Shiraishi
The constitutive androstane receptor (CAR) is a nuclear receptor and transcription factor regulating proteins involved in xenobiotic metabolism. Agonist activation of the CAR can trigger metabolic activation and toxification as well as detoxification and clearance; accordingly, xenobiotic substances acting as CAR ligands may pose a threat to human and animal health. We used yeast cells transduced with the human CAR and the response pathway to measure the CAR-agonistic activities of 549 synthetic or natural compounds: 216 of the tested compounds exhibited CAR-agonistic effects...
September 16, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28927428/current-status-of-insecticide-resistance-among-malaria-vectors-in-kenya
#7
Benyl M Ondeto, Christopher Nyundo, Luna Kamau, Simon M Muriu, Joseph M Mwangangi, Kiambo Njagi, Evan M Mathenge, Horace Ochanda, Charles M Mbogo
BACKGROUND: Insecticide resistance has emerged as one of the major challenges facing National Malaria Control Programmes in Africa. A well-coordinated national database on insecticide resistance (IRBase) can facilitate the development of effective strategies for managing insecticide resistance and sustaining the effectiveness of chemical-based vector control measures. The aim of this study was to assemble a database on the current status of insecticide resistance among malaria vectors in Kenya...
September 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28926222/degradation-of-paraoxon-and-the-chemical-warfare-agents-vx-tabun-and-soman-by-the-metal-organic-frameworks-uio-66-nh2-mof-808-nu-1000-and-pcn-777
#8
Martijn C de Koning, Marco van Grol, Troy Breijaert
In recent years, Zr-based metal-organic frameworks (MOFs) have been developed that facilitate catalytic degradation of toxic organophosphate agents, such as chemical warfare agents (CWAs). Because of strict regulations, experiments using live agents are not possible for most laboratories and, as a result, simulants are used in the majority of cases. Reports that employ real CWAs are scarce and do not cover the whole spectrum of agents. We here present a comparative study in which UiO-66-NH2, NU-1000, MOF-808, and PCN-777 are evaluated for their effectiveness in the degradation of paraoxon and the chemical warfare agents tabun, VX, and soman, in N-ethylmorpholine buffer (pH 10) as well as in pure water...
September 19, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28923753/concentration-and-spatial-distribution-of-organophosphate-esters-in-the-soil-sediment-profile-of-kathmandu-valley-nepal-implication-for-risk-assessment
#9
Ishwar Chandra Yadav, Ningombam Linthoingambi Devi, Jun Li, Gan Zhang, Adrian Covaci
Despite the fact that soil and sediments, which act as a sink or potential source of organic pollutants, have been polluted with organophosphate esters (OPEs) around the globe, extremely constrained data is accessible on environmental concentration and fate of OPEs in solid matrices in whole of the South Asia particularly if there should be an occurrence in Nepal. In this study, surface soil (N=19) and sediments samples (N=20) were analyzed for eight different OPE in Kathmandu Valley during October 2014. The concentration of ∑8OPE measured in sediments samples was 12 times higher than soil and ranged 983-7460ng/g dw (median 2210ng/g dw) and 65-27,500ng/g dw (186ng/g dw), respectively...
September 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28923727/role-of-induced-glutathione-s-transferase-from-helicoverpa-armigera-lepidoptera-noctuidae-hagst-8-in-detoxification-of-pesticides
#10
Chaitali P Labade, Abhilash R Jadhav, Mehul Ahire, Smita S Zinjarde, Vaijayanti A Tamhane
The present study deals with glutathione-S-transferase (GST) based detoxification of pesticides in Helicoverpa armigera and its potential application in eliminating pesticides from the environment. Dietary exposure of a pesticide mixture (organophosphates - chlorpyrifos and dichlorvos, pyrethroid - cypermethrin; 2-15ppm each) to H. armigera larvae resulted in a dose dependant up-regulation of GST activity and gene expression. A variant GST from H. armigera (HaGST-8) was isolated from larvae fed with 10ppm pesticide mixture and it was recombinantly expressed in yeast (Pichia pastoris HaGST-8)...
September 15, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28918601/effects-of-phoxim-induced-hepatotoxicity-on-sd-rats-and-the-protection-of-vitamin-e
#11
Jing Zhang, Wentao Song, Yuecheng Sun, Anshan Shan
Currently, public pay more attention to the adverse effect of organophosphate pesticides on human and animal health and on the environment in developing nations. Vitamin E may protect the hepatocyte and increase the function of liver. The study was to investigate the effects of phoxim-induced hepatotoxicity on Sprague Dawley (SD) rats and the protection of vitamin E. SD rats received by gavage 180 mg kg(-1) (per body weight) of phoxim, 200 mg kg(-1) (per body weight) of vitamin E, and phoxim + vitamin E...
September 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28918158/recombinant-expression-and-characterization-of-lucilia-cuprina-cyp6g3-activity-and-binding-properties-toward-multiple-pesticides
#12
Matthew J Traylor, Jong-Min Baek, Katelyn E Richards, Roberto Fusetto, W Huang, Peter Josh, Zhengzhong Chen, Padma Bollapragada, Richard A J O'Hair, Philip Batterham, Elizabeth M J Gillam
The Australian sheep blowfly, Lucilia cuprina, is a primary cause of sheep flystrike and a major agricultural pest. Cytochrome P450 enzymes have been implicated in the resistance of L. cuprina to several classes of insecticides. In particular, CYP6G3 is a L. cuprina homologue of Drosophila melanogaster CYP6G1, a P450 known to confer multi-pesticide resistance. To investigate the basis of resistance, a bicistronic Escherichia coli expression system was developed to co-express active L. cuprina CYP6G3 and house fly (Musca domestica) P450 reductase...
September 13, 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28913700/mobility-and-dissipation-of-chlorpyriphos-and-quinalphos-in-sandy-clay-loam-in-an-agroecosystem-a-laboratory-based-soil-column-study
#13
Bindumol G P, Harilal C C
Leaching potential of pesticides, apart from climatological factors, depends on soil physical properties, soil-pesticide interaction and chemical nature of the molecule. Recent investigations have revealed the presence of various organophosphate pesticides in various agroecosystems. The present study investigated the soil transport mechanism of commonly used organophosphate pesticides in acidic sandy clay loam soils of Kerala State, India. Packed soil column experiment was undertaken under laboratory condition for 30 days...
September 15, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28911742/inheritance-and-stability-of-mevinphos-resistance-in-plutella-xylostella-l-with-special-reference-to-mutations-of-acetylcholinesterase-1
#14
Chia-Li Lin, Shih-Chia Yeh, Hai-Tung Feng, Shu-Mei Dai
Diamondback moth (Plutella xylostella L.) causes enormous damage on cruciferous vegetables and can rapidly develop resistance to all kinds of insecticides. To effectively manage the insecticide resistance of P. xylostella, an understanding of its inheritance and stability is essential. Here we investigated the phenotypic and genotypic basis of mevinphos resistance by crossing two genetically pure lines of P. xylostella, an SHggt wild-type strain and an SHMTCN resistant strain carrying 892T/T, 971C/C, and 1156T/G (TCN) mutations of the acetylcholinesterase 1 gene (Pxace1)...
September 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28910747/transcriptome-analysis-of-rana-chensinensis-liver-under-trichlorfon-stress
#15
Yu Ma, Bo Li, Yang Ke, Yongan Zhang, Yuhui Zhang
Trichlorfon is a selective organophosphate insecticide that is widely applied in aquaculture and agriculture for control of various parasites. However, repeated and excess applications of trichlorfon often lead to water pollution and threaten non-targeted species. Our previous studies showed that trichlorfon could cause oxidative stress, lipid peroxidation and hepatic lesions in the liver of Rana chensinensis, but the related molecular mechanisms remain unclear. To explore the interference of trichlorfon in gene transcription, the differentially expressed genes in the liver of R...
September 11, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28910084/changes-in-flame-retardant-and-legacy-contaminant-concentrations-in-indoor-air-during-building-construction-furnishing-and-use
#16
Simon Vojta, Lisa Melymuk, Jana Klánová
A newly constructed university building was selected for targeted assessment of changes in the levels of flame retardants and legacy contaminants during the installation of building equipment, furniture and electronics, and first year of building use. Indoor air samples were collected during several periods of intensive equipment installation to determine a relationship between newly-introduced equipment and changes in the concentrations and profiles of contaminants in indoor air. Samples were analysed for polybrominated diphenyl ethers (PBDEs), hexabromocyclododecanes (HBCDDs) and new types of flame retardants - brominated (BFRs) and organophosphate esters (OPEs)...
September 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28904524/prevalence-circumstances-and-management-of-acute-pesticide-poisoning-in-hospitals-in-kampala-city-uganda
#17
Charles Ssemugabo, Abdullah Ali Halage, Ruth Mubeezi Neebye, Victoria Nabankema, Massy Moses Kasule, Deogratius Ssekimpi, Erik Jørs
This study was aimed at assessing prevalence, circumstance, and management of acute pesticide poisoning in hospitals in Kampala. It was a retrospective cross-sectional study that involved reviewing of 739 poisoning patient records from 5 hospitals in Kampala. Of the 739 patients, 212 were due to pesticide poisoning resulting in a prevalence of 28.8%. About 91.4% (191/210) of the cases were due to organophosphate poisoning, 63.3% (133/210) were intentional, and 98.1% (206/210) were exposed through ingestion...
2017: Environmental Health Insights
https://www.readbyqxmd.com/read/28903494/optimization-of-the-ocular-treatment-following-organophosphate-nerve-agent-insult
#18
Inbal Egoz, Uri Nili, Ettie Grauer, Ariel Gore
Eye exposure to organophosphate (OP) irreversible acetylcholinesterase inhibitors, results in long-term miosis and impaired visual function. The aim of this study was to find an anticholinergic antidote, which would counteract miosis and visual impairment induced by the nerve agents sarin and VX with minimal untoward side-effects. Rat pupil width and light reflex were evaluated from 15 min up to 2 weeks following topical OP exposure with or without topical ocular treatment of atropine or homatropine or with a combined intramuscular treatment of trimedoxime (TMB-4) and atropine (TA)...
September 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28902461/behavioral-responses-of-pest-mole-crickets-neoscapteriscus-spp-orthoptera-gryllotalpidae-to-selected-insecticides
#19
Olga S Kostromytska, Michael E Scharf, Eileen A Buss
BACKGROUND: Mole crickets (Neoscapteriscus spp.) consume turfgrasses and pasture grasses and uproot plants by their tunneling, which decreases turf aesthetics and decreases forage quantity and quality. Insecticides are frequently used to prevent damage. In typical field trials, damage symptoms, not percent of mortality or achieved level of control, are used to assess treatment efficacy. Here however, we evaluated the direct effect of key insecticides on Neoscapteriscus mole cricket behavior...
September 13, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28901838/investigation-of-associations-between-exposures-to-pesticides-and-testosterone-levels-in-thai-farmers
#20
Parinya Panuwet, Chandresh Ladva, Dana Boyd Barr, Tippawan Prapamontol, John D Meeker, Priya Esilda D'Souza, Héctor Maldonado, P Barry Ryan, Mark G Robson
We conducted a cross-sectional study to assess the relationship between pesticide exposures and testosterone levels in 133 male Thai farmers. Urine and serum samples were collected concurrently from participants. Urine was analyzed for levels of specific- and non-specific metabolites of organophosphates (OPs), pyrethroids, select herbicides, and fungicides. Serum was analyzed for total and free testosterone. Linear regression analyses revealed significant negative relationships between total testosterone and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) after controlling for covariates (e...
September 13, 2017: Archives of Environmental & Occupational Health
keyword
keyword
22969
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"