Olivia K Provance, Victor O Oria, Thuy T Tran, Jasmine I Caulfield, Christopher R Zito, Adam Aguirre-Ducler, Kurt A Schalper, Harriet M Kluger, Lucia B Jilaveanu
Melanoma has the highest propensity among solid tumors to metastasize to the brain. Melanoma brain metastases (MBM) are a leading cause of death in melanoma and affect 40-60% of patients with late-stage disease. Therefore, uncovering the molecular mechanisms behind MBM is necessary to enhance therapeutic interventions. Vascular mimicry (VM) is a form of neovascularization linked to invasion, increased risk of metastasis, and poor prognosis in many tumor types, but its significance in MBM remains poorly understood...
April 18, 2024: Cellular and Molecular Life Sciences: CMLS