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https://www.readbyqxmd.com/read/29055274/comparative-study-of-4d-cta-and-dsa-for-vascular-assessment-in-moyamoya-disease
#1
Bing Tian, Yuanliang Jiang, Qinqin Kang, Bing Xu, Ri Liu, Qi Liu, Jianping Lu
PURPOSE: To evaluate the vascular stenosis and collateral circulation in moyamoya disease using 4D CTA. METHODS: Two neuroradiologists evaluated 4D CTA and DSA for 101 moyamoya patients. The performance of 4D CTA relative to DSA was determined using consistency checks (kappa values, 95% CI) and correlation analysis. RESULTS: The kappa values were 0.714 (modified Suzuki score), 0.846 (Houkin score), 0.594 (basicranial moyamoya vessels), 0.435 (posterior circulation collaterals) and 0...
October 12, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29055151/prevention-and-management-of-spouting-bleeding-during-endoscopic-submucosal-dissection-for-large-subpedunculated-type-colonic-tumor
#2
Yuzuru Tamaru, Shiro Oka, Shinji Tanaka
Endoscopic submucosal dissection (ESD) is a reliable method for treating superficial colorectal tumors, however it is technically more difficult and requires more experience than gastric ESD, because of difficulties associated with endoscope operability and the anatomical features of the colorectal region, including the presence of folds/flexures, bending of the intestinal tract, and the thinness of the intestinal wall.(1) Main accidental complications during colorectal ESD are perforation and bleeding.(2, 3) With continued bleeding, the visibility of the operative field would deteriorate...
October 21, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29055138/effects-of-a-bone-graft-substitute-consisting-of-porous-gradient-ha-zro2-and-gelatin-chitosan-slow-release-hydrogel-containing-bmp-2-and-bmscs-on-lumbar-vertebral-defect-repair-in-rhesus-monkey
#3
Rong-Xue Shao, Ren-Fu Quan, Tuo Wang, Wei-Bin Du, Gao-Yong Jia, Dong Wang, Long-Bao Lv, Cai-Yin Xu, Xi-Cheng Wei, Jin-Fu Wang, Di-Sheng Yang
Dense biomaterial plays an important role in bone replacement. However, it fails to induce bone-cell migration into graft material. In the present study, a novel bone-graft substitute (BGS) consisting of porous gradient HA/ZrO2 composite (PGHC) and gelatin/chitosan slow-release hydrogel containing BMP-2 and BMSCs was designed and prepared to repair lumbar vertebral defects. The morphological characteristics of the BGS evaluated by scanning electron microscope showed that it had a three-dimensional network structure with uniformly distributed chitosan microspheres on the surfaces of the graft material and the interior of the pores...
October 21, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29055128/a-generalized-outflow-boundary-condition-impedance-model-for-non-invasive-prediction-of-ischemia-in-diseased-coronary-arteries
#4
Iyad A Fayssal, Fadl Moukalled, Samir Alam, Hussain Isma'eel
This paper reports on a new boundary condition formulation to model the total coronary myocardial flow and impedance characteristics of the myocardial vascular bed for any specific patient when considered for non-invasive diagnosis of fractional flow reserve (FFR). The developed boundary condition model inherits an implicit representation of the downstream truncated vascular bed and is based on integrating patient-specific physiologic parameters that can be non-invasively extracted for each patient to account for blood flow demand to the myocardium at rest and hyperemic conditions...
October 21, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29055125/vascular-endothelial-growth-factor-vegf-related-single-nucleotide-polymorphisms-rs10738760-and-rs6921438-are-not-associated-with-diabetic-retinopathy-dr-in-slovenian-patients-with-type-2-diabetes-mellitus-t2dm
#5
Rifet Terzić, Ines Cilenšek, Ruda Zorc Pleskovič, Sara Mankoč, Aleksandra Milutinović
Diabetic retinopathy (DR) is a complication of diabetes characterized by vascular permeability, increased tissue ischemia, and angiogenesis. One of the most important proteins involved in angiogenesis is vascular endothelial growth factor (VEGF, also known as VEGFA). A previous study demonstrated that two single nucleotide polymorphisms (SNPs), rs6921438 and rs10738760, account for nearly half the variation in circulating VEGF levels. The aim of our study was to assess the association between rs6921438 and rs10738760 and DR in Slovenian patients with type 2 diabetes mellitus (T2DM)...
October 20, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29055086/acute-mitogen-activated-protein-kinase-1-2-inhibition-improves-functional-recovery-and-vascular-changes-after-ischemic-stroke-in-rat-monitored-by-9-4-t-magnetic-resonance-imaging
#6
Maryam Mostajeran, Friedrich Wetterling, Frank W Blixt, Lars Edvinsson, Saema Ansar
AIM: The aim was to evaluate the beneficial effect of early mitogen activated protein kinase (MEK)1/2 inhibition administered at a clinical relevant time-point using the transient middle cerebral artery occlusion model and a dedicated rodent magnetic resonance imaging system (9.4T) to monitor cerebrovascular changes non-invasively for two weeks. METHOD: Transient middle cerebral artery occlusion was induced in male rats for two hours followed by reperfusion. The specific MEK1/2 inhibitor U0126 was administered i...
October 21, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/29055073/ppnac1-a-main-regulator-of-phenylalanine-biosynthesis-and-utilization-in-maritime-pine
#7
Mª Belén Pascual, María-Teresa Llebrés, Blanca Craven-Bartle, Rafael A Cañas, Francisco M Cánovas, Concepción Ávila
The transcriptional regulation of phenylalanine metabolism is particularly important in conifers, long-lived species that use large amounts of carbon in wood. Here, we show that the Pinus pinaster transcription factor, PpNAC1, is a main regulator of phenylalanine biosynthesis and utilization. A phylogenetic analysis classified PpNAC1 in the NST proteins group, and was selected for functional characterization. PpNAC1 is predominantly expressed in the secondary xylem and compression wood of adult trees. Silencing of PpNAC1 in P...
October 21, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29054969/%C3%AE-mangostin-protects-against-high-glucose-induced-apoptosis-of-human-umbilical-vein-endothelial-cells
#8
Yanli Luo, Minxiang Lei
Diabetic vascular complications result from high glucose -induced vascular endothelial cell dysfunction. There is an emerging need for novel drugs with vascular endothelial cell -protective effects for the treatment of diabetic vascular complications. This study aimed to investigate the protective effect of α-mangostin against high-glucose-induced apoptosis of cultured human umbilical vein endothelial cells (HUVECs). HUVECs were treated with glucose to induce apoptosis. The expression of the apoptosis-related proteins, Bcl-2, Bax and cleaved caspase-3, were detected by Western blotting...
October 20, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29054942/primary-hepatic-hemangioendothelioma-in-a-patient-with-budd-chiari-syndrome
#9
Preet Mukesh Shah, Vijay Waman Dhakre, Aabha Nagral
A 36-year-old woman was diagnosed with compensated cirrhosis of liver secondary to Budd-Chiari syndrome (BCS) and had undergone stenting of a thrombosed left hepatic vein. Eight months later, she presented with jaundice and right upper quadrant pain. CT revealed multiple focal lesions in the liver, which on biopsy proved to be hepatic hemangioendothelioma (HHE). Her liver disease and ascites progressively increased. Four months later, magnetic resonance cholangiopancreatography showed an advanced stage of HHE with infiltration of the common bile duct and vascular invasion with a blocked stent, with metastasis to the spleen and dorsolumbar vertebrae...
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054861/regulation-of-human-feto-placental-endothelial-barrier-integrity-by-vascular-endothelial-growth-factors-competitive-interplay-between-vegf-a165a-vegf-a165b-pigf-and-ve-cadherin
#10
Vincent Pang, David O Bates, Lopa Leach
The human placenta nourishes and protects the developing fetus whilst influencing maternal physiology for fetal advantage. It expresses several members of the VEGF family including the pro-angiogenic/pro-permeability VEGF-A165a isoform, the anti-angiogenic VEGF-A165b, placental growth factor (PIGF) and their receptors, VEGFR1 and VEGFR2. Alterations in the ratio of these factors during gestation and in complicated pregnancies have been reported; however the impact of this on feto-placental endothelial barrier integrity is unknown...
October 20, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29054860/post-prandial-hyperlipidaemia-results-in-systemic-nitrosative-stress-and-impaired-cerebrovascular-function-in-the-aged
#11
Christopher J Marley, Danielle Hodson, Julien V Brugniaux, Lewis Fall, Damian Miles Bailey
Post-prandial hyperlipidaemia (PPH) acutely impairs systemic vascular endothelial function, potentially attributable to a free radical-mediated reduction in vascular nitric oxide (NO) bioavailability (oxidative-nitrosative stress). However, it remains to be determined whether this extends to the cerebrovasculature. To examine this, 38 (19 young (≤ 35 years) and 19 aged (≥ 60 years)) healthy males were recruited. Cerebrovascular function (middle cerebral artery velocity, MCAv) and cerebrovascular reactivity to hypercapnea (CVRCO2Hyper) and hypocapnea (CVRCO2Hypo) were determined via trans-cranial Doppler ultrasound and capnography...
October 20, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29054842/acute-biventricular-mechanical-circulatory-support-for-cardiogenic-shock
#12
Sudeep Kuchibhotla, Michele L Esposito, Catalina Breton, Robert Pedicini, Andrew Mullin, Ryan O'Kelly, Mark Anderson, Dennis L Morris, George Batsides, Danny Ramzy, Mark Grise, Duc Thinh Pham, Navin K Kapur
BACKGROUND: Biventricular failure is associated with high in-hospital mortality. Limited data regarding the efficacy of biventricular Impella axial flow catheters (BiPella) support for biventricular failure exist. The aim of this study was to explore the clinical utility of percutaneously delivered BiPella as a novel acute mechanical support strategy for patients with cardiogenic shock complicated by biventricular failure. METHODS AND RESULTS: We retrospectively analyzed data from 20 patients receiving BiPella for biventricular failure from 5 tertiary-care hospitals in the United States...
October 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29054773/microsurgical-vs-endovascular-treatments-for-blood-blister-aneurysms-of-the-internal-carotid-artery-a-retrospective-study-of-83-patients-in-a-single-center
#13
Yanming Ren, Lunxin Liu, Hong Sun, Yi Liu, Hao Li, Lu Ma, Chang-Wei Zhang, Xiao-Dong Xie, Min He, Chao You, Jin Li
BACKGROUND: Blood-blister aneurysms (BBAs) of the internal carotid artery (ICA) are challenging lesions with high morbidity and mortality. Currently, both surgical and endovascular approaches have been used to treat the BBAs; however, little is known about their safety and efficacy. OBJECTIVE: To review our experience with the treatment of BBAs and explore the optimal treatment strategy. METHODS: A total of 83 patients with BBAs were reviewed retrospectively...
October 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29054771/spinal-cavernous-angioma-associated-with-klippel-trenaunay-weber-syndrome-a-case-report-and-literature-review
#14
Kazunori Oda, Daijiro Morimoto, Kyongsong Kim, Kanako Yui, Takao Kitamura, Akio Morita
Klippel-Trenaunay-Weber syndrome (KTWS) is a rare congenital vascular disorder characterized by the classic triad of cutaneous nevi, venous varicosities, and osseous and soft tissue hypertrophy of the affected limb. Various vascular anomalies of the central nervous system have also been described in patients with this syndrome. The English-language literature to date contains six reports of associations between KTWS and spinal cord cavernous angioma (CA), but the management of these patients has not been well described...
October 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29054690/removable-rigid-dressings-for-postoperative-management-of-transtibial-amputations-a-review-of-published-evidence
#15
REVIEW
James P Reichmann, Phillip M Stevens, John Rheinstein, Christopher D Kreulen
Forty years of clinical experience and peer reviewed research studies support the use of non-weight bearing removable rigid dressings (RRD) as an effective means of post-operative management of transtibial amputations. We reviewed the published medical evidence regarding the use of RRDs as a postoperative management strategy, culminating in an evidence-based practice recommendation. Published peer reviewed literature on the topic was searched and classified by level of evidence based on the research design utilizing the scale recommended by the PM&R Journal (level I through V)...
October 17, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29054601/disruption-of-trpv3-impairs-heat-evoked-vasodilation-and-thermoregulation-a-critical-role-of-cgrp
#16
Berengere Fromy, Audrey Josset-Lamaugarny, Géraldine Aimond, Aurélie Pagnon-Minot, Irène Marics, Glenn J Tattersall, Aziz Moqrich, Dominique Sigaudo-Roussel
Sensing environmental temperature is a key factor allowing individuals to maintain thermal homeostasis via thermoregulatory mechanisms, including changes to skin blood flow. Among transient receptor potential (TRP) channels, TRPV3 is a heat-activated cation channel highly expressed in keratinocytes. However, the role of TRPV3 in triggering heat-evoked cutaneous vasodilation is unknown. Using a murine in vivo model of local acute environmental heat exposure in the skin, we show that TRPV3 is involved in the local thermoregulatory control of skin blood flow by initiating the release of calcitonin gene-related peptide (CGRP) and nitric oxide (NO) in response to local heating of the skin...
October 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29054554/second-look-arthroscopic-evaluation-of-repaired-radial-oblique-tears-of-the-midbody-of-the-lateral-meniscus-in-stable-knees
#17
Akira Tsujii, Hiroshi Amano, Yoshinari Tanaka, Keisuke Kita, Ryohei Uchida, Yoshiki Shiozaki, Shuji Horibe
BACKGROUND: Radial/oblique tears of the midbody of the lateral meniscus significantly impair the ability of the meniscus to withstand the tibiofemoral load, requiring meniscal repair. However, healing status after meniscal repair has not been fully elucidated. This study aimed to evaluate arthroscopic findings after inside-out suture repair for isolated radial/oblique tears of the midbody of the lateral meniscus. METHODS: From 2011 to 2015, 18 consecutive patients with isolated radial/oblique tears of the midbody of the lateral meniscus underwent arthroscopic inside-out repair with the tie-grip suture technique...
October 18, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29054389/optimizing-surgical-quality-datasets-to-care-for-older-adults-lessons-from-the-american-college-of-surgeons-nsqip-geriatric-surgery-pilot
#18
Julia R Berian, Lynn Zhou, Melissa A Hornor, Marcia M Russell, Mark E Cohen, Emily Finlayson, Clifford Y Ko, Thomas N Robinson, Ronnie A Rosenthal
BACKGROUND: Surgical quality datasets can be better tailored toward older adults. The American College of Surgeons (ACS) NSQIP Geriatric Surgery Pilot collected risk factors and outcomes in 4 geriatric-specific domains: cognition, decision-making, function, and mobility. This study evaluated the contributions of geriatric-specific factors to risk adjustment in modeling 30-day outcomes and geriatric-specific outcomes (postoperative delirium, new mobility aid use, functional decline, and pressure ulcers)...
September 28, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29054372/simultaneously-overcome-tumor-vascular-endothelium-and-extracellular-matrix-barriers-via-a-non-destructive-size-controlled-nanomedicine
#19
Binghua Wang, Yongxia Zhai, Jinjin Shi, Luyang Zhuang, Wei Liu, Huijuan Zhang, Hongling Zhang, Zhenzhong Zhang
Tumor vascular endothelium and extracellular matrix (ECM) as the major barriers of anticancer nanomedicine greatly limited the anticancer efficacy of treatment, but few strategies were available to overcome them simultaneously. Thus, herein a strategy was presented to utilize reversible vasodilatation effect of nitric oxide (NO) and size-controlled characteristic of ultrasound responsive liposome (URL) to construct a non-destructive nanomedicine, which was able to cross both obstacles simultaneously. In this work, URL was built as a carrier via forming a gas layer between lipid bilayer to encapsulate small particles PAMAM@DOX (PD, ~10nm) and NO donation-nitrosoglutathione (GSNO)...
October 17, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29054354/strategies-to-reduce-ischemia-reperfusion-injury-in-vascularized-composite-allotransplantation-of-the-limb
#20
REVIEW
Kavit R Amin, Jason K F Wong, James E Fildes
An important and often underinvestigated contributor to solid organ transplant rejection is ischemia reperfusion injury. This pathophysiological response releases damaging reactive oxygen species and cell stress signals that initiate inflammation, which has a critical role in priming the immune system for allorecognition. In time, this renders graft dysfunction and how this response is mediated in composite tissues remains unknown. Current protocols are drawn from solid organ transplantation with little scientific basis as to how this informs current hand transplantation practices...
October 18, 2017: Journal of Hand Surgery
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