Bernardino Ossola, Ali Rifat, Anna Rowland, Helen Hunter, Samuel Drinkall, Clare Bender, Mayida Hamlischer, Martin Teall, Russell Burley, Dan Barker, David Cadwalladr, Louise Dickson, Jason Lawrence, Jenna Harvey, Marina Lizio, Xiao Xu, Edel Kavanagh, Toni Cheung, Steve Sheardown, Catherine B Lawrence, Michael Harte, David Brough, Christian Madry, Kim Matthews, Kevin Doyle, Keith Page, Justin Powell, Nicola L Brice, Roland W Bürli, Mark B Carlton, Lee A Dawson
Neuroinflammation, specifically the NLRP3 inflammasome cascade, is a common underlying pathological feature of many neurodegenerative diseases. Evidence suggests that NLRP3 activation involves changes in intracellular K+ . Nuclear Enriched Transcript Sort Sequencing (NETSseq), which allows for deep sequencing of purified cell types from human post-mortem brain tissue, demonstrated a highly specific expression of the tandem pore domain halothane-inhibited K+ channel 1 (THIK-1) in microglia compared to other glial and neuronal cell types in the human brain...
November 11, 2022: Neuropharmacology