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https://www.readbyqxmd.com/read/29471602/-evolving-therapeutic-strategies-in-the-inflammatory-bowel-disease
#1
REVIEW
Soo Young Na, Won Moon
It is important to have effective therapeutic strategies and goals in clinical practice and research of inflammatory bowel disease. Conventional end points for clinical trials in Crohn's disease and ulcerative colitis have been based on composite indices, such as the Crohn's Disease Activity Index and the Mayo Clinic Score. Although these indices have been shown to reduce the intestinal injury to some extent, satisfactory results have not been obtained in improving the quality of life of patients. Recently, alternative measures of outcome and definitions of response are being developed beyond symptoms...
February 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29471595/circulating-piiinp-levels-identify-adipose-tissue-associated-inflammation-in-individuals-with-type-2-diabetes-mellitus-with-and-without-non-alcoholic-fatty-liver-disease
#2
I Barchetta, F A Cimini, R De Gioannis, G Ciccarelli, L Bertoccini, A Lenzi, M G Baroni, M G Cavallo
AIMS: Procollagen-III peptide (PIIINP) is a marker of fibrosis associated with increased cardio-metabolic risk and progression of chronic liver diseases such as non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH); its association with type 2 diabetes mellitus has not been elucidated yet. Aim of this study was to investigate the relationship between circulating PIIINP levels, metabolic traits and body fat distribution in subjects with T2DM with or without NAFLD. MATERIALS AND METHODS: Data from sixty-two T2DM subjects recruited in our Diabetes outpatient clinics at Sapienza University of Rome, Italy, were analysed...
February 22, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29471591/improvement-of-life-quality-measured-by-lansky-score-after-enzymatic-replacement-therapy-in-children-with-gaucher-disease-type-1
#3
Magdalena Cerón-Rodríguez, Edgar Barajas-Colón, Lyuva Ramírez-Devars, Claudia Gutiérrez-Camacho, Juan L Salgado-Loza
BACKGROUND: Gaucher disease type 1 (GD1, OMIM# 230800), is a condition with high impact in patient's quality of life (QoL). We report the improvement in QoL of children with GD1 measured by Lansky play-performance scale (LS) after enzymatic replacement therapy (ERT) and to describe our experience in the treatment of children with GD1. METHODS: Five children with diagnosis of GD1 received imiglucerase 60 mg/kg every two weeks. LS, hepatomegaly, splenomegaly, hemoglobin, platelets, and growth rate were measured every 6 months after beginning ERT for 30 months...
January 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29471582/diabetic-dyslipidaemia-is-associated-with-alterations-in-enos-caveolin-1-and-endothelial-dysfunction-in-streptozotocin-treated-rats
#4
Yousif A Shamsaldeen, Rosemary Ugur, Christopher D Benham, Lisa A Lione
BACKGROUND: Diabetes is a complex progressive disease characterised by chronic hyperglycaemia and dyslipidaemia associated with endothelial dysfunction. Oxidised LDL (Ox-LDL) is elevated in diabetes and may contribute to endothelial dysfunction. The aim of this study was to relate the serum levels of Ox-LDL with endothelial dysfunction in streptozotocin (STZ)-diabetic rats and to further explore the changes in endothelial nitric oxide synthase (eNOS) and caveolin-1 (CAV-1) expression in primary aortic endothelial cells (ECs)...
February 22, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29471575/-breast-cancer-diagnostics-and-therapy-the-most-important-facts-for-internists
#5
Ulrich Hamann, Christine Ankel
LEARNING OBJECTIVES:  After reviewing this article, the participant should be able to: 1. Understand the epidemiology of breast cancer, its incidence and impact. 2. Appreciate the importance of early diagnosis and treatment. 3. Understand the concept of comprehensive breast cancer management and its multidisciplinarity. 4. Be knowledgeable about the entire process required to manage breast cancer, since the early diagnosis until the management of non breast related conditions derived from the treatment...
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29471542/specialized-pro-resolving-lipid-mediators-regulate-ozone-induced-pulmonary-and-systemic-inflammation
#6
Brita Kilburg-Basnyat, Sky W Reece, Miranda J Crouch, Bin Luo, Andria D Boone, Michael Yaeger, Myles Hodge, Christine Psaltis, Johanna L Hannan, Jonathan Manke, Michael L Armstrong, Nichole Reisdorph, Robert M Tighe, Saame Raza Shaikh, Kymberly M Gowdy
Exposure to ozone (O3) induces lung injury, pulmonary inflammation, and alters lipid metabolism. During tissue inflammation, specialized pro-resolving lipid mediators (SPMs) facilitate the resolution of inflammation. SPMs regulate the pulmonary immune response during infection and allergic asthma; however, the role of SPMs in O3-induced pulmonary injury and inflammation is unknown. We hypothesized that O3 exposure induces pulmonary inflammation by reducing SPMs. To evaluate this, male C57Bl/6J mice were exposed to filtered air (FA) or 1 ppm O3 for 3h and necropsied 24h after exposure...
February 19, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29471541/the-caucasian-nasal-septum-an-in-vivo-computed-tomography-study
#7
Charles Daultrey, John Hardman, Shahram Anari
Background: The nasal septum is composed of cartilaginous and bony components and an understanding of each component volume is essential in both functional and cosmetic surgery. Objectives: We sought to radiographically measure septal dimensions on cross sectional computer tomography (CT) images, establishing average parameters for normal anatomy among a single, Caucasian population group. Methods: One hundred and fifty consecutive sinus CT scan images were examined and 100 cases with appropriate sagittal views were included in the study...
February 19, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29471539/breaking-down-barriers-to-the-utilization-of-standardized-tests-and-outcome-measures-in-acute-care-physical-therapist-practice-an-observational-longitudinal-study
#8
Brian McDonnell, Shannon Stilwell, Shelby Hart, Roger B Davis
Background: Standardized tests and outcome measures (STOM) have not been consistently implemented as part of most physical therapists' practice. Incidence of STOM use amongst physical therapists at Beth Israel Deaconess Medical Center was similar to low levels cited nationally among acute care physical therapists. Targeted knowledge translation (KT) strategies have been suggested to promote the application of research evidence into clinical decision making. Purpose: The purpose of this quality improvement (QI) effort was to implement a series of interventions aimed at increasing both use and interpretation of STOM by physical therapists practicing in acute care...
February 19, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29471538/novel-roles-of-ascorbate-in-plants-induction-of-cytosolic-ca2-signals-and-efflux-from-cells-via-anion-channels
#9
M Makavitskaya, D Svistunenko, I Navaselsky, P Hryvusevich, V Mackievic, C Rabadanova, E Tyutereva, V Samokhina, D Straltsova, A Sokolik, O Voitsekhovskaja, V Demidchik
Ascorbate is not often considered as a signalling molecule in plants. This study demonstrates that, in Arabidopsis roots, exogenous L-ascorbic acid triggers a transient increase of the cytosolic free calcium activity ([Ca2+]cyt.) that is central to plant signalling. Exogenous copper and iron stimulates the ascorbate-induced [Ca2+]cyt. elevation while cation channel blockers, free radical scavengers, low extracellular [Ca2+], transition metal chelators and removal of the cell wall inhibit this reaction. These data show that apoplastic redox-active transition metals are involved in the ascorbate-induced [Ca2+]cyt...
February 17, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29471533/reproducibility-of-work-ability-and-work-functioning-instruments
#10
A van Schaaijk, K Nieuwenhuijsen, M H W Frings-Dresen, J K Sluiter
Background: Work ability (WA) and work functioning (WF) instruments can be useful in occupational health practice. The reproducibility of both instruments is important to their relevance for daily practice. Clinimetrics concerns the methodological and statistical quality of instruments and their performance in practice. Aims: To assess the reproducibility of WA and WF instruments. Methods: Dutch workers completed a questionnaire containing WA questions and the WF questionnaire twice with a 7-day interval between...
February 17, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29471531/carbon-monoxide-poisoning-in-wood-pellet-storerooms
#11
N Golob, D Grenc, M Brvar
Background: Carbon monoxide is the leading cause of mortality from unintentional poisoning in Slovenia. It has been shown that carbon monoxide levels can rise in wood pellet storerooms because of chemical degradation of pellets, even at room temperature. We present a case of lethal carbon monoxide poisoning with first responder carbon monoxide exposure. Aims: To highlight the dangers rescuers face during interventions in pellet storerooms and the need for preventive precautions...
February 17, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29471519/higher-risk-of-abdominal-obesity-elevated-ldl-cholesterol-and-hypertriglyceridemia-but-not-of-hypertension-in-people-living-with-hiv-results-from-the-copenhagen-comorbidity-in-hiv-infection-cocomo-study
#12
Marco Gelpi, Shoaib Afzal, Jens Lundgren, Andreas Ronit, Ashley Roen, Amanda Mocroft, Jan Gerstoft, Anne-Mette Lebech, Birgitte Lindegaard, Klaus Fuglsang Kofoed, Børge G Nordestgaard, Susanne Dam Nielsen
Background: People living with HIV (PLWH) have lower life expectancy than uninfected individuals, partly explained by excess risk of cardiovascular diseases (CVD) and CVD risk factors. We investigated the association between HIV infection and abdominal obesity, elevated LDL cholesterol (LDL-C), hypertriglyceridemia and hypertension, in a large cohort of predominantly well-treated PLWH and matched controls. Methods: 1,099 PLWH from the Copenhagen Co-morbidity in HIV infection (COCOMO) study and 12,161 age and sex-matched uninfected controls from the Copenhagen General Population Study were included and underwent blood pressure, waist-, hip-, weight-, and height-measurements...
February 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29471516/optical-spectral-transmission-to-assess-inflammation-in-hand-and-wrist-joints-of-rheumatoid-arthritis-patients
#13
Nick J Besselink, Patricia van der Meijde, Wouter H J Rensen, Peter B L Meijer, Anne C A Marijnissen, Jacob M van Laar, Floris P J G Lafeber, Johannes W G Jacobs
Objective: To develop an optical spectral transmission (OST) model to measure joint inflammation, and thus disease activity, as well as to evaluate (patho-)physiological findings that could lead to misclassification of inflammation. Methods: Forty-six RA patients were included in this cross-sectional study, where US scores, duplicate OST measurements and 28-joint DAS (DAS28) were acquired. With US as a reference standard, the diagnostic performance of OST in detecting inflammation at the joint level was evaluated using receiver operating characteristic (ROC) curve analyses...
February 19, 2018: Rheumatology
https://www.readbyqxmd.com/read/29471504/anodyne-by-design-measuring-the-prevalence-of-esoteric-designer-opioids-in-pain-management-patients
#14
Melissa M Goggin, Stephanie D Gozum, Anna Miller, Gregory C Janis
The recent increase in illicit opioids sold on the black market, cut into heroin and masqueraded as prescription pills prompts a significant public health concern. Most designer opioids possess unknown potencies and unknown pharmacokinetics and their unregulated, variable dosages lead to rashes of overdoses. Additionally, many of the designer opioids, especially the fentanyl analogs are significantly more potent than heroin. High-profile cases involving overdoses of U-47700 and carfentanil have been reported in the media; however, the true prevalence of these and other designer opioids is unknown...
February 17, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29471500/molecular-identification-of-leishmania-spp-in-sand-flies-diptera-psychodidae-phlebotominae-in-the-len%C3%A3-%C3%A3-is-maranhenses-national-park-brazil
#15
Adalberto Alves Pereira-Filho, Raquel Silva Fonteles, Maria da Conceição Abreu Bandeira, Jorge Luiz Pinto Moraes, José Manuel Macário Rebêlo, Maria Norma Melo
Sand flies are very common in the region of Lençóis Maranhenses National Park, an important tourist attraction in Brazil. However, the role of some species and their relative importance locally in Leishmania Ross 1903 transmission is unclear. The objective of this study was to identify Leishmania infection in phlebotomine sand flies collected around the Lençóis Maranhenses National Park, an important conservation area and popular international/national tourist destination with a high incidence of leishmaniasis...
February 20, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29471498/-it-was-the-best-worst-day-of-my-life-narrative-content-structure-and-process-in-wisdom-fostering-life-event-memories
#16
Nic M Weststrate, Michel Ferrari, Marc A Fournier, Kate C McLean
Objectives: The purpose of this study was to examine laypeople's subjective understanding of their own wisdom development. To do this, autobiographical memories of wisdom-fostering life events were examined for (a) life-event characteristics, and (b) self-reflective processes believed to support growth in wisdom through life experience. Methods: Midlife adults (N = 482) provided a written autobiographical memory of a wisdom-fostering life event. Memories were content analyzed by expert coders for life-event characteristics (i...
February 20, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29471493/the-effect-of-pregnancy-on-endometriosis-facts-or-fiction
#17
Brigitte Leeners, Fabia Damaso, Nicole Ochsenbein-Kölble, Cindy Farquhar
BACKGROUND: It is not uncommon for women with endometriosis to be advised that becoming pregnant might be a useful strategy to manage their symptoms and reduce disease progression. Consequently, many women diagnosed with endometriosis and motivated to become pregnant, may also have expectations regarding improvement of symptoms and the disease. However, study results on the effect of pregnancy on endometriosis are controversial and pregnancy in women with endometriosis is not always associated with improved symptoms...
February 15, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29471486/selection-of-hyperproduction-of-ampc-and-sme-1-in-a-carbapenem-resistant-serratia-marcescens-isolate-during-antibiotic-therapy
#18
Peera Hemarajata, Thomas Amick, Shangxin Yang, Aric Gregson, Cameron Holzmeyer, Karen Bush, Romney M Humphries
Objectives: Antibiotic selective pressure may result in changes to antimicrobial susceptibility throughout the course of infection, especially for organisms that harbour chromosomally encoded AmpC β-lactamases, notably Enterobacter spp., in which hyperexpression of ampC may be induced following treatment with cephalosporins. In this study, we document a case of bacteraemia caused by a blaSME-1-harbouring Serratia marcescens that subsequently developed resistance to expanded-spectrum cephalosporins, piperacillin/tazobactam and fluoroquinolones, over the course of several months of treatment with piperacillin/tazobactam and ciprofloxacin...
February 19, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29471483/transfer-accuracy-of-two-indirect-bonding-techniques-an-in-vitro-study-with-3d-scanned-models
#19
Johanna Schmid, Daniel Brenner, Wolfgang Recheis, Philipp Hofer-Picout, Martin Brenner, Adriano G Crismani
Background and objectives: Indirect bonding (IDB) proved to be an effective method for appropriate bracket positioning in patients. Different methods and materials are available for fabricating transfer trays. This in vitro study was designed to measure and compare the transfer accuracy of two common IDB methods. Materials and methods: Sixty stone models were fabricated and separated in two groups of 30 models each (15 working models, 15 patient models). After placing brackets on the working models, 30 IDB trays were made: 15 silicone (method I) and 15 double-vacuum forms (method II)...
February 19, 2018: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29471479/seasonal-effects-and-the-impact-of-in-hive-pesticide-treatments-on-parasite-pathogens-and-health-of-honey-bees
#20
Brenna E Traver, Haley K Feazel-Orr, Katelyn M Catalfamo, Carlyle C Brewster, Richard D Fell
Honey bee, Apis mellifera (L.; Hymenoptera: Apidae), populations are in decline and their losses pose a serious threat for crop pollination and food production. The specific causes of these losses are believed to be multifactorial. Pesticides, parasites and pathogens, and nutritional deficiencies have been implicated in the losses due to their ability to exert energetic stress on bees. While our understanding of the role of these factors in honey bee colony losses has improved, there is still a lack of knowledge of how they impact the immune system of the honey bee...
February 17, 2018: Journal of Economic Entomology
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