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https://www.readbyqxmd.com/read/29668136/-a-fatal-case-series-of-rocky-mountain-spotted-fever-in-sonora-m%C3%A3-xico
#1
Jesús Delgado-De la Mora, Jesús David Licona-Enríquez, Marcia Leyva-Gastélum, David Delgado-De la Mora, Adela Rascón-Alcantar, Gerardo Álvarez-Hernández
INTRODUCTION: Rocky Mountain spotted fever is a highly lethal infectious disease, particularly if specific treatment with doxycycline is given belatedly. OBJECTIVE: To describe the clinical profile of fatal Rocky Mountain spotted fever cases in hospitalized patients in the state of Sonora, México. MATERIALS AND METHODS: We conducted a cross-sectional study on a series of 47 deaths caused by Rickettsia rickettsii from 2013 to 2016. The diagnosis of Rocky Mountain spotted fever was confirmed in a single blood sample by polymerase chain reaction (PCR) or by a four-fold increase in immunoglobulin G measured in paired samples analyzed by indirect immunofluorescence...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29668114/-%C3%AE-2-adrenoceptors-inhibit-neutrophil-extracellular-traps-in-human-polymorphonuclear-leukocytes
#2
Franca Marino, Angela Scanzano, Laura Pulze, Monica Pinoli, Emanuela Rasini, Alessandra Luini, Raffaella Bombelli, Massimiliano Legnaro, Magda de Eguileor, Marco Cosentino
This study tests the hypothesis that in isolated human polymorphonuclear leukocytes (PMN) adrenergic ligands can affect neutrophil extracellular trap (NET) formation. We have previously shown that, in PMN, adrenaline (A), through the activation of adrenergic receptors (AR), reduces stimulus-dependent cell activation; we have, therefore, planned to investigate if AR are involved in NET production. PMN were obtained from venous blood of healthy subject. The ability of adrenergic ligands to affect reactive oxygen species (ROS) production, NET production, and cell migration was investigated in cells cultured under resting conditions or after activation with N-formyl-methionyl-leucyl-phenylalanine (fMLP), LPS, or IL-8...
April 18, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29668112/pharmacogenetic-manipulation-of-the-nucleus-accumbens-alters-binge-like-alcohol-drinking-in-mice
#3
Kush Purohit, Puja K Parekh, Joseph Kern, Ryan W Logan, Zheng Liu, Yanhua Huang, Colleen A McClung, John C Crabbe, Angela R Ozburn
BACKGROUND: Chronic alcohol intake leads to long-lasting changes in reward- and stress-related neuronal circuitry. The nucleus accumbens (NAc) is an integral component of this circuitry. Here, we investigate the effects of DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) on neuronal activity in the NAc and binge-like drinking. METHODS: C57BL/6J mice were stereotaxically injected with AAV2 hSyn-HA hM3Dq, -hM4Di, or -eGFP bilaterally into NAc [core + shell, core or shell]...
April 18, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29668108/sonographic-assessment-of-swallowing-in-irradiated-nasopharyngeal-carcinoma-patients
#4
Dennis T H Cheng, Kathy Y S Lee, Anil T Ahuja, Michael C F Tong
OBJECTIVES/HYPOTHESIS: Ultrasonography is an emerging clinical tool to study the dysfunction of swallowing muscles. This was the first sonographic study to assess the relationship between suprahyoid muscle contraction, hyoid bone displacement, and penetration-aspiration status (PAS) during swallowing in nasopharyngeal carcinoma (NPC) patients treated with radiotherapy (RT). The study also aimed to establish reliability data for the sonographic technique described. STUDY DESIGN: Cross-sectional study...
April 18, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29668101/different-ways-to-assess-diseases-prevalence-what-exactly-do-we-measure
#5
E Sbidian
No abstract text is available yet for this article.
April 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29668050/long-term-outcome-of-selective-neurectomy-for-refractory-periocular-synkinesis
#6
Martinus M van Veen, Joseph R Dusseldorp, Tessa A Hadlock
OBJECTIVE: The objective of this study was to investigate the long-term effect and treatment stability of selective neurectomy for refractory periocular synkinesis. METHODS: We performed a retrospective review of all patients treated with highly selective neurectomy for refractory periocular synkinesis between August 2009 and August 2015. Primary outcome was time to recommencing treatment for periocular synkinesis. Palpebral fissure width was measured preoperatively, postoperatively, and at long-term ( > 2...
April 18, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29668045/when-does-the-influence-of-maturation-on-anthropometric-and-physical-fitness-characteristics-increase-and-subside
#7
Christopher Towlson, Stephen Cobley, Guy Parkin, Ric Lovell
The relationships between maturation and anthropometric and physical performance characteristics are dynamic and often asynchronous; confounding the capability to accurately evaluate performance during adolescence. This study aimed to (i) examine the influence of chronological age (CA) and somatic maturation (YPHV) upon anthropometric and physical performance parameters, and (ii) identify the transition/change time-points in these relationships using segmental regression. N=969 soccer players (8-18 years of age) completed anthropometric and physical test assessments, including a counter-movement jump (CMJ), agility T-test, 10 and 20m sprints, and multi-stage fitness test (MSFT)...
April 18, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29668041/warming-intensify-co-2-flux-and-nutrient-release-from-algal-wrack-subsidies-on-sandy-beaches
#8
M Lastra, J López, I F Rodil
Algal wrack subsidies underpin most of the food web structure of exposed sandy beaches, and are responsible of important biogeochemical processes that link marine and terrestrial ecosystems. The response in decomposition of algal wrack deposits to global warming has not been studied in ocean exposed sandy beaches to date. With this aim, passive open top chambers (OTCs) were used to increase soil temperature within the range predicted by the IPCC for western Europe (between 0.5 and 1.5 °C), following the hypothesis that the biogeochemical processing of macroalgal wrack subsidies would accelerate in response to temperature increase...
April 18, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29668034/response-of-formed-biofilm-of-enterobacter-cloacae-klebsiella-oxytoca-and-citrobacter-freundii-to-chlorite-based-disinfectants
#9
Linlin Cai, Huawei Wang, Lijiao Liang, Guangyu Wang, Xinglian Xu, Huhu Wang
Bacterial biofilms formed on equipment surfaces are potential sources of cross-contamination and can be responsible for the spread of bacteria involved in food spoilage, such as some Enterobacteriaceae family members. In this study, the effect of chlorite-based disinfectants, including sodium hypochlorite (SH), chlorine dioxide (CD), strongly acidic electrolyzed water (StAEW), and neutral electrolyzed water (NEW), on inactivation of mono-biofilms of Enterobacter cloacae, Klebsiella oxytoca, and Citrobacter freundii was evaluated separately...
April 18, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29668029/health-adjusted-life-expectancy-in-canada
#10
Tracey Bushnik, Michael Tjepkema, Laurent Martel
BACKGROUND: Over the past century, life expectancy at birth in Canada has risen substantially. However, these gains in the quantity of life say little about gains in the quality of life. DATA AND METHODS: Health-adjusted life expectancy (HALE), an indicator of quality of life, was estimated for the household and institutional populations combined every four years from 1994/1995 to 2015. Health status was measured by the Health Utilities Index Mark 3 instrument in two national population health surveys, and was used to adjust life expectancy...
April 18, 2018: Health Reports
https://www.readbyqxmd.com/read/29668028/reallocating-time-between-sleep-sedentary-and-active-behaviours-associations-with-obesity-and-health-in-canadian-adults
#11
Rachel C Colley, Isabelle Michaud, Didier Garriguet
BACKGROUND: Moderate-to-vigorous physical activity (MVPA) and sleep are positively associated with adults' health, while the association with sedentary behaviour (SED) is negative. Light-intensity physical activity (LPA) is emerging as an independent predictor of improved cardiovascular health. The health impacts of each of these factors have been examined in isolation, but interest has increased in associations between health and movement behaviours collectively. DATA AND METHODS: This analysis examines how reallocating time between movement behaviours is associated with obesity and with self-rated general and mental health...
April 18, 2018: Health Reports
https://www.readbyqxmd.com/read/29667992/naked-eye-and-electrochemical-detection-of-isothermally-amplified-hotair-long-non-coding-rna
#12
Md Nazmul Islam, Sofia Moriam, Muhammad Umer, Hoang-Phuong Phan, Carlos Salomon, Richard Kline, Nam-Trung Nguyen, Muhammad J A Shiddiky
An inexpensive, simple and rapid sensor platform capable of detecting cancer-related long non-coding RNA (lncRNA) with high accuracy is of great interest in the field of molecular diagnostics. Herein, we report on the development of a new colorimetric and electrochemical assay platform for long non-coding HOX transcript antisense intergenic RNA (HOTAIR) detection. Isothermal reverse transcription-recombinase polymerase amplification (RT-RPA) was performed to amplify HOTAIR sequences from a RNA pool extracted from a designated number of ovarian cancer cells and a small cohort of plasma samples derived from patients with ovarian cancer...
April 18, 2018: Analyst
https://www.readbyqxmd.com/read/29667952/useful-pharmacodynamic-endpoints-in-children-selection-measurement-and-next-steps
#13
REVIEW
Lauren E Kelly, Yashwant Sinha, Charlotte I S Barker, Joseph F Standing, Martin Offringa
Pharmacodynamic (PD) endpoints are essential for establishing the benefit-to-risk ratio for therapeutic interventions in children and neonates. This article discusses the selection of an appropriate measure of response, the PD endpoint, which is a critical methodological step in designing pediatric efficacy and safety studies. We provide an overview of existing guidance on the choice of PD endpoints in pediatric clinical research. We identified several considerations relevant to the selection and measurement of PD endpoints in pediatric clinical trials, including the use of biomarkers, modeling, compliance, scoring systems, and validated measurement tools...
April 18, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29667934/brain-computer-interaction-for-online-enhancement-of-visuospatial-attention-performance
#14
Romain Trachel, Thomas Brochier, Maureen Clerc
OBJECTIVE: the goal of this study is to investigate whether BCI that decode the location of covert attention can be leveraged to enhance visuospatial attention performance. Here, the covert attention task is to discriminate the orientation of a low-contrast target embedded in dynamic noise. Visuospatial attention performance is measured by the reaction time and the accuracy of target discrimination. APPROACH: The target location is indicated by a central cue made of randomly moving dots providing either predictive or ambiguous information...
April 18, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29667933/a-cbct-study-of-the-gravity-induced-movement-in-rotating-rabbits
#15
Jeffrey Barber, Chun-Chien Shieh, William Counter, Jonathan R Sykes, Peter Bennett, Verity Ahern, Stéphanie Corde, Soo-Min Heng, Paul White, Michael Jackson, Paul Liu, Paul J Keall, Ilana Feain
Fixed-beam radiotherapy systems with subjects rotating about a longitudinal (horizontal) axis are subject to gravity-induced motion. Limited reports on the degree of this motion, and any deformation, has been reported previously. The purpose of this study is to quantify the degree of anatomical motion caused by rotating a subject around a longitudinal axis, using cone-beam CT (CBCT). 
 
 In the current study, a purpose-made longitudinal rotating was aligned to a Varian TrueBeam kV imaging system...
April 18, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29667932/fused-data-transrectal-eit-for-prostate-cancer-imaging
#16
Ethan K Murphy, Xiaotian Wu, Ryan J Halter
OBJECTIVE: Prostate cancer is a significant problem affecting 1 in 7 men. Unfortunately, the diagnostic gold-standard of ultrasound-guided biopsy misses 10-30% of all cancers. The objective of this study was to develop an Electrical Impedance Tomography (EIT) approach that has the potential to image the entire prostate using multiple impedance measurements recorded between electrodes integrated onto an end-fired transrectal ultrasound (TRUS) device and a biopsy probe (BP). APPROACH: Simulations and sensitivity analyses were used to investigate the best combination of electrodes, and measured tank experiments were used to evaluate a fused-data transrectal EIT (fd-TREIT) and BP approach...
April 18, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29667910/role-of-wnk4-and-kidney-specific-wnk1-in-mediating-the-effect-of-high-dietary-k-intake-on-romk-channel-in-the-distal-convoluted-tubule
#17
Peng Wu, Zhong-Xiuzi Gao, Xiao-Tong Su, David H Ellison, Juliette Hadchouel, Jacques Teulon, Wen-Hui Wang
With-no-lysine kinase 4 (WNK4) and kidney-Specific (KS)-WNK1 regulate ROMK (Kir1.1) channels in a variety of cell models. We now explore the role of WNK4 and KS-WNK1 in regulating ROMK in the native distal convoluted tubule (DCT)/connecting tubule (CNT) by measuring TPNQ (ROMK inhibitor)-sensitive K+ currents with whole-cell recording. TPNQ-sensitive K+ currents in DCT2/CNT of KS-WNK1-/- and WNK4-/- mice were significantly smaller than that of WT mice. In contrast, the basolateral K+ channels (a Kir4.1/5.1 heterotetramer) in the DCT were not inhibited...
April 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29667909/losartan-does-not-decrease-renal-oxygenation-and-norepinephrine-effects-in-rats-after-resuscitated-haemorrhage
#18
Sofia Jönsson, Jacqueline M Melville, Mediha Becirovic-Agic, Michael Hultström
Renin-angiotensin-system blockers are thought to increase the risk of acute kidney injury after surgery and haemorrhage. We found that Losartan does not cause renal cortical hypoxia after haemorrhage in rats because of decreased renal vascular resistance, but did not evaluate resuscitation. AIM: Study Losartan´s effect on renal cortical and medullary oxygenation, and norepinephrine´s vasopressor effect in a model of resuscitated haemorrhage. METHOD: After seven days Losartan (60 mg/kg/day) or control treatment, male Wistar rats were haemorrhaged 20 % of the blood volume and resuscitated with Ringer's Acetate...
April 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29667907/direct-peritoneal-resuscitation-reduces-leukocyte-infiltration-in-the-kidney-after-acute-brain-death
#19
Jessica Lee Weaver, Paul J Matheson, Amy Matheson, Victoria S Graham, Cynthia Downard, Richard Neal Garrison, Jason W Smith
Brain death is associated with significant inflammation within the kidneys, which may contribute to reduced graft survival. Direct peritoneal resuscitation (DPR) has been shown to reduce systemic inflammation after brain death. To determine its effects, brain dead rats were resuscitated with normal saline (targeted intravenous fluid, TIVF) to maintain a mean arterial pressure of 80 mmHg and DPR animals also received 30cc of intraperitoneal peritoneal dialysis solution. Rats were euthanized at zero, two, four, and six hours after brain death...
April 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29667896/a-phase-1-study-to-assess-the-pharmacokinetics-safety-and-tolerability-of-fremanezumab-doses-225-mg-675-mg-and-900-mg-in-japanese-and-caucasian-healthy-subjects
#20
Orit Cohen-Barak, Sivan Weiss, Michele Rasamoelisolo, Nicola Faulhaber, Paul P Yeung, Pippa S Loupe, Esther Yoon, Mohit D Gandhi, Ofer Spiegelstein, Ernesto Aycardi
Objectives The primary and secondary objectives of this phase 1 study were to evaluate the pharmacokinetic profile, safety, and immunogenicity of fremanezumab subcutaneous (sc) doses tested in phase 2 and 3 trials (225 mg, 675 mg and 900 mg) following single administration in Japanese (n = 32) and Caucasian (n = 32) healthy subjects. Methods Japanese and matched Caucasian healthy subjects were enrolled into one of four cohorts and were randomly assigned to one of four treatments: 225, 675, or 900 mg fremanezumab, or placebo...
January 1, 2018: Cephalalgia: An International Journal of Headache
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