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https://www.readbyqxmd.com/read/28934833/hemodynamic-analysis-of-radiation-induced-damage-in-common-carotid-arteries-by-using-color-doppler-ultrasonography
#1
Alireza Mohammadkarim, Manijhe Mokhtari-Dizaji, Ali Kazemian, Hazhir Saberi
Purpose: The aim of this study was to assess vascular changes and blood flow abnormalities in the common carotid arteries of patients with head and neck cancers after external radiotherapy, using color Doppler ultrasonography. Methods: We studied 24 patients treated with external radiotherapy for various head and neck cancers. In order to study the acute effects of irradiation on common carotid blood flow and arterial diameter changes, color Doppler ultrasonography parameters such as peak systolic velocity, end diastolic velocity, mean velocity, systolic-to-diastolic velocity (S/D) ratio, pulsatility index (PI), resistive index (RI), and instantaneous diameter changes were evaluated before and after external radiotherapy...
April 14, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28934822/stent-placement-for-benign-esophageal-leaks-perforations-and-fistulae-a-clinical-prediction-rule-for-successful-leakage-control
#2
Emo E van Halsema, Wouter F W Kappelle, Bas L A M Weusten, Robert Lindeboom, Mark I van Berge Henegouwen, Paul Fockens, Frank P Vleggaar, Manon C W Spaander, Jeanin E van Hooft
Background and study aims Sealing esophageal leaks by stent placement allows healing in 44 % - 94 % of patients. We aimed to develop a prediction rule to predict the chance of successful stent therapy. Patients and methods In this multicenter retrospective cohort study, patients with benign upper gastrointestinal leakage treated with stent placement were included. We used logistic regression analysis including four known clinical predictors of stent therapy outcome. The model performance to predict successful stent therapy was evaluated in an independent validation sample...
September 21, 2017: Endoscopy
https://www.readbyqxmd.com/read/28934811/current-utilization-and-acceptance-of-multiparametric-mri-in-the-diagnosis-of-prostate-cancer-a-regional-survey
#3
Tim Ullrich, Lars Schimmöller, Mathias Oymanns, Dirk Blondin, Frederic Dietzel, Julian Kirchner, Christian Arsov, Robert Rabenalt, Peter Albers, Gerald Antoch, Michael Quentin
Purpose To assess the current regional acceptance, valuation, and clinical role of multiparametric MRI (mp-MRI) in prostate cancer diagnostics by patients and physicians. Materials and Methods Of 482 distributed standardized questionnaires, 328 patient and 31 physician questionnaires (urological and general practitioners in and around Düsseldorf) were analyzed over a period of 11 months. Questions were asked concerning general knowledge about prostate cancer, current diagnostic procedures, and knowledge about mp-MRI and MRI-guided biopsy...
September 21, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28934805/ratings-of-perceived-exertion-and-physiological-responses-in-children-during-exercise
#4
Jennifer M Erichsen, Brandon J Dykstra, Mary C Hidde, Anthony D Mahon
OMNI ratings of perceived exertion (RPE) and physiological responses in children (n=7 boys, 8 girls, 11.1±1.0 years) were examined during estimation (graded exercise test [GXT] and steady-state) and production (steady-state) trials on a cycle ergometer. Peak oxygen consumption (VO2peak) was determined via a GXT with RPE estimated every 30 s. Later, two 6-min trials were completed: Participants 1) estimated RPE at ~75% of VO2peak, 2) produced a level of exertion corresponding to their RPE at ~75% of VO2peak during the GXT...
September 21, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28934786/long-term-cost-utility-of-spinal-cord-stimulation-in-patients-with-failed-back-surgery-syndrome
#5
S Harrison Farber, Jing L Han, Aladine A Elsamadicy, Qasim Hussaini, Siyun Yang, Promila Pagadala, Beth Parente, Jichun Xie, Shivanand P Lad
BACKGROUND: Failed back surgery syndrome (FBSS) is a cause of significant morbidity for up to 40% of patients following spine surgery, and is estimated to cost almost $20 billion. Treatment options for these patients currently include conventional medical management (CMM), repeat operation, or spinal cord stimulation (SCS). Much of the published data regarding cost effectiveness of SCS comprise smaller scale randomized controlled trials (RCTs) rather than large databases capturing practices throughout the US...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934783/serious-adverse-events-associated-with-readmission-through-one-year-after-vertebral-augmentation-with-either-a-polyetheretherketone-implant-or-balloon-kyphoplasty
#6
Douglas P Beall, Jeffrey D Coe, Mark McIlduff, Daniel Bloch, John Hornberger, Christopher Warner, Sean Tutton
BACKGROUND: The KAST (Kiva Safety and Efficacy) investigation device exempt (IDE) study indicated that the majority of patients responded equally well to vertebral augmentation using either an implant-based approach or balloon kyphoplasty (BK). Additional investigation has suggested that a subset of patients may benefit further by avoiding repeated readmissions due to serious adverse events (SAEs) if they receive one vertebral augmentation approach over another. OBJECTIVES: The primary aim was to assess the effect of 2 different augmentation procedures on readmission rates for SAEs...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934769/assessment-and-modelling-of-general-practice-and-community-setting-capacity-for-medical-trainees-in-northern-new-zealand
#7
Felicity Goodyear-Smith, Abbas Al-Murrani
AIMS: To estimate the capacity of general practice to accommodate undergraduate and postgraduate medical trainees, and model efficient ways to utilise identified capacity and increase capacity. METHODS: We conducted an online survey, with phone follow-up to non-responders, of all general practices in the northern half of New Zealand. The main outcome measures were current placements and future intentions for taking medical trainees; factors influencing decisions and possible incentives to take trainees...
September 22, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28934767/family-planning-unmet-need-and-access-among-itaukei-women-in-new-zealand-and-fiji
#8
Radilaite Cammock, Peter Herbison, Sarah Lovell, Patricia Priest
AIM: The aim of the study was to identify unmet need and family planning access among indigenous Fijian or iTaukei women living in New Zealand and Fiji. METHOD: A cross-sectional survey was undertaken between 2012-2013 in five major cities in New Zealand: Auckland, Hamilton, Wellington, Christchurch and Dunedin; and in three suburbs in Fiji. Women who did not want any (more) children but were not using any form of contraception were defined as having an unmet need...
September 22, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28934766/new-zealand-women-have-suboptimal-intakes-of-long-chain-omega-3-polyunsaturated-fatty-acids-during-pregnancy-a-cross-sectional-study
#9
Michele Eickstaedt, Kathryn L Beck, Cathryn A Conlon
AIM: To investigate dietary intakes and food sources of polyunsaturated fatty acids in New Zealand pregnant women. METHOD: Women (n=596) 16 years plus in trimester three of pregnancy completed an online food frequency questionnaire validated for omega-3 and omega-6 polyunsaturated fatty acids. RESULTS: Estimated median [25th, 75th percentile] intakes of omega-3 polyunsaturated fatty acids were: 1,300 [790, 2,120] mg/d alpha-linolenic acid (adequate intake 1,000mg/d); 220 [120, 520] mg/d total long chain omega-3 polyunsaturated fatty acids (adequate intake 115mg/d); and 110 [50, 250] mg/d docosahexaenoic acid (recommended 200mg/d)...
September 22, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28934761/comparison-between-mri-and-pathology-in-the-assessment-of-tumour-regression-grade-in-rectal-cancer
#10
Francesco Sclafani, Gina Brown, David Cunningham, Andrew Wotherspoon, Larissa Sena Teixeira Mendes, Svetlana Balyasnikova, Jessica Evans, Clare Peckitt, Ruwaida Begum, Diana Tait, Josep Tabernero, Bengt Glimelius, Susana Roselló, Janet Thomas, Jacqui Oates, Ian Chau
BACKGROUND: Limited data exist regarding the correlation between MRI tumour regression grade (mrTRG) and pathological TRG (pTRG) in rectal cancer. METHODS: mrTRG and pTRG were compared in rectal cancer patients from two phase II trials (EXPERT and EXPERT-C). The agreement between radiologist and pathologist was assessed with the weighted κ test while the Kaplan-Meier method was used to estimate survival outcomes. RESULTS: One hundred ninety-one patients were included...
September 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28934735/effect-of-shikonin-on-spinal-cord-injury-in-rats-via-regulation-of-hmgb1-tlr4-nf-kb-signaling-pathway
#11
Yihui Bi, Yapeng Zhu, Mingkai Zhang, Keke Zhang, Xingyi Hua, Zheng Fang, Jian Zhou, Wenjie Dai, Yixing Cui, Jun Li, Tao You
BACKGROUND/AIMS: Shikonin, a compound extracted from Zicao, has been demonstrated to hold anti-bacterial, anti-inflammatory, and anti-tumor activities in various diseases and it has been shown to protect human organs from injuries. However, the effect of shikonin on the recovery of spinal cord injury (SCI) remains unknown. This study was designed to estimate the potential therapeutic effect and underlying mechanism of shikonin on SCI in vivo. METHODS: In the study, we used HE staining, ELISA assay, transfection assay, TUNEL assay, real time PCR and Western blot to detect the effects of shikonin on spinal cord injury in rats...
September 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28934731/fasting-spot-urine-ph-is-associated-with-metabolic-syndrome-in-the-japanese-population
#12
Masanori Shimodaira, Shinji Okaniwa, Tomohiro Nakayama
OBJECTIVE: To investigate the relationship between urine pH and metabolic syndrome (MetS) and its components while controlling for covariates. SUBJECTS AND METHODS: This cross-sectional study was conducted on 5,430 Japanese subjects (4691 without MetS; 739 with MetS) undergoing health assessments. Partial correlation analysis and analysis of covariance were used for controlling confounding parameters (age, gender, serum uric acid (UA) levels, high sensitivity C-reactive protein, estimated glomerular filtration rate, and smoking and drinking statuses)...
September 19, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28934727/in-utero-exposure-to-select-phenols-and-phthalates-and-respiratory-health-in-five-year-old-boys-a-prospective-study
#13
Céline Vernet, Isabelle Pin, Lise Giorgis-Allemand, Claire Philippat, Meriem Benmerad, Joane Quentin, Antonia M Calafat, Xiaoyun Ye, Isabella Annesi-Maesano, Valérie Siroux, Rémy Slama
BACKGROUND: Phenols and phthalates may have immunomodulatory and proinflammatory effects and thereby adversely affect respiratory health. OBJECTIVE: We estimated the associations between gestational exposure to select phthalates and phenols and respiratory health in boys. METHODS: Among 587 pregnant women from the EDEN (Etude des Déterminants pré et post natals du développement et de la santé de l'Enfant) cohort who delivered a boy, 9 phenols and 11 phthalates metabolites were quantified in spot pregnancy urine samples...
September 8, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28934722/rice-consumption-and-squamous-cell-carcinoma-of-the-skin-in-a-united-states-population
#14
Anala Gossai, M Scot Zens, Tracy Punshon, Brian P Jackson, Ann E Perry, Margaret R Karagas
BACKGROUND: Rice contains arsenic, a known skin carcinogen. Rice intake has been associated with arsenic-related skin lesions in South Asia, but its association with skin cancers is as yet unknown. OBJECTIVES: We aimed to investigate whether rice intake contributes to urinary arsenic concentration and risk of squamous cell carcinoma (SCC) of the skin in a U.S. population. METHODS: Rice consumption was assessed using a food frequency questionnaire administered as part of a population-based case-control study of 487 SCC cases and 462 age- and gender-matched controls...
September 7, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28934720/prenatal-exposure-to-perfluoroalkyl-substances-and-cardiometabolic-risk-in-children-from-the-spanish-inma-birth-cohort-study
#15
Cyntia B Manzano-Salgado, Maribel Casas, Maria-Jose Lopez-Espinosa, Ferran Ballester, Carmen Iñiguez, David Martinez, Dora Romaguera, Silvia Fernández-Barrés, Loreto Santa-Marina, Mikel Basterretxea, Thomas Schettgen, Damaskini Valvi, Jesus Vioque, Jordi Sunyer, Martine Vrijheid
BACKGROUND: Perfluoroalkyl substances (PFAS) may affect body mass index (BMI) and other components of cardiometabolic (CM) risk during childhood, but evidence is scarce and inconsistent. OBJECTIVES: We estimated associations between prenatal PFAS exposures and outcomes relevant to cardiometabolic risk, including a composite CM-risk score. METHODS: We measured perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) in maternal plasma (first trimester)...
September 20, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28934716/automatic-detection-of-micronuclei-by-cell-microscopic-image-processing
#16
Mohammad Taghi Bahreyni Toossi, Hosein Azimian, Omid Sarrafzadeh, Shokoufeh Mohebbi, Shokouhozaman Soleymanifard
With the development and applications of ionizing radiation in medicine, the radiation effects on human health get more and more attention. Ionizing radiation can lead to various forms of cytogenetic damage, including increased frequencies of micronuclei (MNi) and chromosome abnormalities. The cytokinesis block micronucleus (CBMN) assay is widely used method for measuring MNi to determine chromosome mutations or genome instability in cultured human lymphocytes. The visual scoring of MNi is time-consuming and scorer fatigue can lead to inconsistency...
August 12, 2017: Mutation Research
https://www.readbyqxmd.com/read/28934683/histological-transformations-of-the-dental-pulp-as-possible-indicator-of-post-mortem-interval-a-pilot-study
#17
Patricio A Carrasco, Claudia I Brizuela, Ismael A Rodriguez, Samuel Muñoz, Marianela E Godoy, Carolina Inostroza
BACKGROUND: The correct estimation of the post mortem interval (PMI) can be crucial on the success of a forensic investigation. Diverse methods have been used to estimate PMI, considering physical changes that occur after death, such as mortis algor, livor mortis, among others. Degradation after death of dental pulp is a complex process that has not yet been studied thoroughly. It has been described that pulp RNA degradation could be an indicator of PMI, however this study is limited to 6 days...
September 11, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28934680/a-phase-1-study-of-the-janus-kinase-2-jak2-v617f-inhibitor-gandotinib-ly2784544-in-patients-with-primary-myelofibrosis-polycythemia-vera-and-essential-thrombocythemia
#18
Srdan Verstovsek, Ruben A Mesa, Mohamed E Salama, Li Li, Celine Pitou, Fabio P Nunes, Gregory L Price, Jennifer L Giles, Deborah N D'Souza, Richard A Walgren, Josef T Prchal
Mutations in Janus kinase 2 (JAK2) are implicated in the pathogenesis of Philadelphia-chromosome negative myeloproliferative neoplasms, including primary myelofibrosis, polycythemia vera, and essential thrombocythemia. Gandotinib (LY2784544), a potent inhibitor of JAK2 activity, shows increased potency for the JAK2(V617F) mutation. The study had a standard 3+3 dose-escalation design to define the maximum-tolerated dose. Primary objectives were to determine safety, tolerability, and recommended oral daily dose of gandotinib for patients with JAK2(V617F)-positive myelofibrosis, essential thrombocythemia, or polycythemia vera...
August 31, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28934657/characterisation-of-artisanal-mine-waste-on-buru-island-indonesia-and-toxicity-to-the-brittle-star-amphipholis-squamata
#19
Amanda J Reichelt-Brushett, Bernard Thomas, Pelli L Howe, Yusthinus Male, Malcolm W Clark
Artisanal small-scale gold mining (ASGM) using mercury (Hg) amalgamation commenced on Buru Island, Indonesia, in 2012, but was halted in 2015 due to concerns of widespread Hg contamination. Much of the Hg used in the mining process is lost to trommel waste which is disposed of in settlement ponds that drain into adjacent waterways and into Kayeli Bay. Several thousand unmanaged trommel sites and associated tailing ponds exist on Buru Island. This study shows that waste from the Marloso trommel at the Gogrea site contained 203 mg/kg total Hg (THg), with a negligible proportion present as bioavailable methyl Hg (MeHg) and a low total organic carbon content...
September 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28934612/measuring-and-modeling-for-the-assessment-of-the-genetic-background-behind-cognitive-processes-in-donkeys
#20
Francisco Javier Navas, Jordi Jordana, José Manuel León, Ander Arando, Gabriela Pizarro, Amy Katherine McLean, Juan Vicente Delgado
New productive niches can offer new commercial perspectives linked to donkeys' products and human therapeutic or leisure applications. However, no assessment for selection criteria has been carried out yet. First, we assessed the animal inherent features and environmental factors that may potentially influence several cognitive processes in donkeys. Then, we aimed at describing a practical methodology to quantify such cognitive processes, seeking their inclusion in breeding and conservation programmes, through a multifactorial linear model...
September 14, 2017: Research in Veterinary Science
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