keyword
https://read.qxmd.com/read/38547404/assessment-of-associations-between-inhaled-formaldehyde-and-lymphohematopoietic-cancer-through-integration-of-epidemiological-and-toxicological-evidence-with-biological-plausibility
#1
JOURNAL ARTICLE
M J Vincent, S Fitch, L Bylsma, C Thompson, S Rogers, J Britt, D Wikoff
Formaldehyde is recognized as carcinogenic for portal of entry sites, though conclusions are mixed regarding lymphohematopoietic (LHP) cancers. This systematic review assesses the likelihood of a causal relationship between formaldehyde and LHP cancers by integrating components recommended by NASEM. Four experimental rodent bioassays and 16 observational studies in humans were included following implementation of the a priori protocol. All studies were assessed for risk of bias (RoB), and meta-analyses conducted on epidemiological studies, followed by a structured assessment of causation based on GRADE and Bradford Hill...
March 28, 2024: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/38547396/predicting-oncology-drug-induced-cardiotoxicity-with-donor-specific-ipsc-cms-a-proof-of-concept-study-with-doxorubicin
#2
JOURNAL ARTICLE
Li Pang, Chengzhong Cai, Praful Aggarwal, Dong Wang, Vikrant Vijay, Prathyusha Bagam, Jacob Blamer, Andrea Matter, Amy Turner, Lijun Ren, Katy Papineau, Vinodh Srinivasasainagendra, Hemant K Tiwari, Xi Yang, Laura Schnackenberg, William Mattes, Ulrich Broeckel
Many oncology drugs have been found to induce cardiotoxicity in a subset of patients, which significantly limits their clinical use and impedes the benefit of lifesaving anti-cancer treatments. Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) carry donor-specific genetic information and have been proposed for exploring the inter-individual difference in oncology drug-induced cardiotoxicity. Herein, we evaluated the inter- and intra- individual variability of iPSC-CM-related assays and presented a proof of concept to prospectively predict doxorubicin (DOX)-induced cardiotoxicity (DIC) using donor-specific iPSC-CMs...
March 28, 2024: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/38547313/distribution-of-2-2-5-5-tetrachlorobiphenyl-pcb52-metabolites-in-adolescent-rats-after-acute-nose-only-inhalation-exposure
#3
JOURNAL ARTICLE
Amanda J Bullert, Xueshu Li, Binita Gautam, Hui Wang, Andrea Adamcakova-Dodd, Kai Wang, Peter S Thorne, Hans-Joachim Lehmler
Inhalation of PCB-contaminated air is increasingly recognized as a route for PCB exposure. Because limited information about the disposition of PCBs following inhalation exposure is available, this study investigated the disposition of 2,2',5,5'-tetrachlorobiphenyl (PCB52) and its metabolites in rats following acute, nose-only inhalation of PCB52. Male and female Sprague-Dawley rats (50-58 days of age, 210 ± 27 g; n = 6) were exposed for 4 h by inhalation to approximately 14 or 23 μg/kg body weight of PCB52 using a nose-only exposure system...
March 28, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38547303/prevalence-and-associated-factors-of-occupational-injuries-in-an-industrial-city-in-ghana
#4
JOURNAL ARTICLE
Michael Tetteh Asiedu, Douglas Aninng Opoku, Nana Kwame Ayisi-Boateng, Joseph Osarfo, Alhassan Sulemana, Aliyu Mohammed, John Amissah, Jennifer Ashilevi, Ayongo Mate-Kole, Felix Agyemang Opoku, Isaac Kofi Yankson, Emmanuel Kweku Nakua
BACKGROUND: Workers are exposed to workplace hazards which increase their risk of occupational injury. Data on occupational injuries and associated factors are important for planning and informing national policy regarding workplace health and safety. This study sought to estimate the prevalence and factors associated with occupational injuries among workers in an industrial city in Ghana. METHODS: A community-based cross-sectional survey was conducted among 459 workers in the Tema industrial enclave in Ghana from 22nd December 2020 to 27th February 2021...
2024: PloS One
https://read.qxmd.com/read/38547300/a-pilot-randomised-controlled-trial-comparing-the-effectiveness-of-the-materre180-participatory-tool-including-a-serious-game-versus-an-intervention-including-carbon-footprint-awareness-raising-on-behaviours-among-academia-members-in-france
#5
JOURNAL ARTICLE
Claudia Teran-Escobar, Nicolas Becu, Nicolas Champollion, Nicolas Gratiot, Benoît Hingray, Gérémy Panthou, Isabelle Ruin
BACKGROUND: Activities embedded in academic culture (international conferences, field missions) are an important source of greenhouse gas emissions. For this reason, collective efforts are still needed to lower the carbon footprint of Academia. Serious games are often used to promote ecological transition. Nevertheless, most evaluations of their effects focus on changes in knowledge and not on behaviour. The main objectives of this study are to 1) Evaluate the feasibility of a control and an experimental behaviour change intervention and, 2) Evaluate the fidelity (the extent to which the implementation of the study corresponds to the original design) of both interventions...
2024: PloS One
https://read.qxmd.com/read/38547258/qbnb-an-innovative-c2b2c2b2c-e-commerce-mode-for-integrated-on-demand-services
#6
JOURNAL ARTICLE
Yaoyao Wei, Cuiyin Yao, Wei-Fan Chen, Tian Xie, Jinzhao Yang
The traditional supply-side-driven e-commerce modes provide consumers with massive amounts of structured information about goods and services. Due to the lack of a tailor-made ability to describe, explain, and accurately understand unstructured service demands, existing technologies and service modes still struggle to fully explore, articulate, and meet the personalized, high-quality, and urgent service demands of the disadvantaged groups in e-commerce. This paper innovatively proposes the concept of "integrated services on demand" and develops its C2B2C2B2C-based "Qbnb" e-commerce mode, operation mechanism and intermediary platform architecture...
2024: PloS One
https://read.qxmd.com/read/38547241/health-professionals-technology-readiness-on-the-acceptance-of-teleradiology-in-the-amhara-regional-state-public-hospitals-northwest-ethiopia-using-technology-readiness-acceptance-model-tram
#7
JOURNAL ARTICLE
Araya Mesfin Nigatu, Tesfahun Melese Yilma, Lemma Derseh Gezie, Yonathan Gebrewold, Monika Knudsen Gullslett, Shegaw Anagaw Mengiste, Binyam Tilahun
BACKGROUND: Considering individual differences caused by personality differences is crucial for end users' technology acceptance. However, previous studies overlooked the influence of users' technology readiness on technology acceptance. This study, therefore, aimed to evaluate the influence of technology readiness on teleradiology acceptance in the Amhara Regional State Public Hospitals using a technology readiness acceptance model. METHODS: An institutional-based cross-sectional mixed study design was conducted in September 2021 among 547 health professionals working at sixteen public hospitals in the Amhara region of northwest Ethiopia...
2024: PloS One
https://read.qxmd.com/read/38547238/older-women-s-experience-with-covid-19-pandemic-a-study-of-risk-perception-and-coping-among-culturally-and-linguistically-diverse-population-in-south-australia
#8
JOURNAL ARTICLE
Noore Alam Siddiquee, Mohammad Hamiduzzaman, Helen McLaren, Emi Patmisari
BACKGROUND: A global catastrophe-the COVID-19 pandemic-appears to have two-dimensional health consequences for older adults: high risk of being infected and psychological distress. There is limited evidence on how the pandemic has impacted the life and coping of older adults who are culturally and linguistically diverse (CALD), women in particular. This study explored the COVID-19 risk perception and coping strategies of older CALD women in South Australia. METHODS: A mixed-methods research design was employed, involving a 31-items coping and emergency preparation scale for survey and semi-structured interviews with participants...
2024: PloS One
https://read.qxmd.com/read/38547231/compact-rover-surveying-and-laser-scanning-for-bim-development
#9
JOURNAL ARTICLE
Syed Riaz Un Nabi Jafri, Syed Murtaza Hussain, Asif Ahmed, Syed Asher Hussain Rizvi, Kumayl Hassan Kazmi, Jamshed Iqbal
This paper presents a custom made small rover based surveying, mapping and building information modeling solution. Majority of the commercially available mobile surveying systems are larger in size which restricts their maneuverability in the targeted indoor vicinities. Furthermore their functional cost is unaffordable for low budget projects belonging to developing markets. Keeping in view these challenges, an economical indigenous rover based scanning and mapping system has developed using orthogonal integration of two low cost RPLidar A1 laser scanners...
2024: PloS One
https://read.qxmd.com/read/38547229/feasibility-of-using-low-cost-markerless-motion-capture-for-assessing-functional-outcomes-after-lower-extremity-musculoskeletal-cancer-surgery
#10
JOURNAL ARTICLE
Sherron Furtado, Brook Galna, Alan Godfrey, Lynn Rochester, Craig Gerrand
BACKGROUND: Physical limitations are frequent and debilitating after sarcoma treatment. Markerless motion capture (MMC) could measure these limitations. Historically expensive cumbersome systems have posed barriers to clinical translation. RESEARCH QUESTION: Can inexpensive MMC [using Microsoft KinectTM] assess functional outcomes after sarcoma surgery, discriminate between tumour sub-groups and agree with existing assessments? METHODS: Walking, unilateral stance and kneeling were measured in a cross-sectional study of patients with lower extremity sarcomas using MMC and standard video...
2024: PloS One
https://read.qxmd.com/read/38547222/factors-associated-with-hepatitis-a-susceptibility-among-men-who-have-sex-with-men-using-hiv-pre-exposure-prophylaxis-in-northeastern-brazil-a-cross-sectional-study
#11
JOURNAL ARTICLE
Hareton Teixeira Vechi, Mônica Baumgardt Bay, Cláudio Henrique Silva de Freitas, Júlia Gomes Fernandes Costa de Sant'anna, Carlos Brites, Kenio Costa de Lima
Hepatitis A virus (HAV) infection has disproportionately affected more men who have sex with men (MSM), occurring in outbreaks, despite being vaccine-preventable. We determined the prevalence and factors associated with HAV susceptibility among cisgender MSM on HIV pre-exposure prophylaxis (PrEP) in Northeastern Brazil. From September 30, 2021 to June 19, 2023, 282 cisgender MSM receiving HIV PrEP were enrolled into this cross-sectional study. Sociodemographic and clinical information were collected. Blood samples were collected for screening of sexually transmitted infections (STIs) and serum samples were tested for IgM and total anti-HAV antibodies...
2024: PloS One
https://read.qxmd.com/read/38547221/does-attitude-importance-moderate-the-effects-of-person-first-language-a-registered-report
#12
JOURNAL ARTICLE
Sandy Schumann, Hazem Zohny
Previous research has demonstrated that exposure to outgroup descriptions that use person-first, as compared to identity-first, language can attenuate negative stereotypes or prejudice and enhance support for policies that seek to advance outgroup rights. However, those benefits of person-first language may not apply to all social groups equally. The present study examines a boundary condition of the effects of person-first language. Specifically, we postulate that person-first language reduces the stigmatization of outgroups to a lesser degree if individuals hold more important negative attitudes towards the respective communities...
2024: PloS One
https://read.qxmd.com/read/38547214/from-opt-out-to-opt-in-consent-for-secondary-use-of-medical-data-and-residual-biomaterial-an-evaluation-using-the-re-aim-framework
#13
JOURNAL ARTICLE
Jennifer E Lutomski, Peggy Manders
BACKGROUND: Patient records, imaging, and residual biomaterial from clinical procedures are crucial resources for medical research. In the Netherlands, consent for secondary research has historically relied on opt-out consent. For ethical-legal experts who purport passive consent undermines patient autonomy, opt-in consent (wherein affirmative action is required) is seen as the preferred standard. To date, there is little empirical research exploring patient feasibility, organizational consequences, and the potential risks for research based on secondary data...
2024: PloS One
https://read.qxmd.com/read/38547211/short-term-chemotherapy-related-complications-and-undernutrition-in-children-diagnosed-with-cancer-at-korle-bu-teaching-hospital-accra-ghana-a-prospective-cohort-study
#14
JOURNAL ARTICLE
Nihad Salifu, Catherine I Segbefia, Yakubu Alhassan, Lorna A Renner, Edem M A Tette
Undernutrition in children with cancer is associated with complications during cancer therapy. The study objective was to determine the association between specific anthropometric parameters and short-term chemotherapy-related complications and mortality. This was a hospital-based, prospective cohort study of children, age ≤12 years, with a new cancer diagnosis at the Paediatric Oncology Unit, Korle Bu Teaching Hospital, Ghana. Socio-demographic information, cancer characteristics and anthropometric measurements were obtained at enrolment...
2024: PloS One
https://read.qxmd.com/read/38547210/using-simulation-to-teach-nursing-students-how-to-deal-with-a-euthanasia-request
#15
JOURNAL ARTICLE
Dennis Demedts, Jürgen Magerman, Ellen Goossens, Sandra Tricas-Sauras, Johan Bilsen, Stefaan De Smet, Maaike Fobelets
Nursing students are confronted with euthanasia during their internship and certainly during their later career but they feel inadequately prepared in dealing with a euthanasia request. This study presents a simulation module focused on euthanasia and evaluates nursing students' perceptions after they have completed the simulation practice. The 'euthanasia module' consisted of a preparatory online learning module, a good-practice video, an in-vivo simulation scenario, and a debriefing session. The module's content was validated by four experts in end-of-life care...
2024: PloS One
https://read.qxmd.com/read/38547200/prognostic-difference-between-surgery-and-external-radiation-in-patients-with-stage-i-liver-cancer-based-on-competitive-risk-model-and-conditional-survival-rate
#16
JOURNAL ARTICLE
Rong Chen, Yanli An, Muhao Xu
PURPOSE: This study aimed to assess the difference in prognosis of patients with early-stage liver cancer after surgery or external radiation. METHODS: Between 2010 and 2015, 2155 patients with AJCC 7th stage I liver cancer were enrolled in the SEER database. Among these, 1972 patients had undergone surgery and 183 had undergone external beam radiation. The main research endpoints were overall survival (OS) and disease-specific survival (DSS). The competitive risk model was used to calculate the risk ratio of liver cancer-specific deaths when there was a competitive risk...
2024: PloS One
https://read.qxmd.com/read/38547188/exploring-the-neurofunctional-impairments-and-cognitive-biases-concerning-food-and-body-related-stimuli-in-anorexia-nervosa-an-integrated-eeg-and-eye-tracking-study-protocol
#17
JOURNAL ARTICLE
Panagiotis Loizou, Georgia Panagiotou, Panos Zanos, Evangelos Paraskevopoulos
BACKGROUND: Patients with Anorexia Nervosa (AN) exhibit significant cognitive and neural disturbances compared to healthy individuals when processing food and body-related stimuli. These disturbances not only contribute to the manifestation and chronification of their pathological eating behaviour but also underscore the complex interplay of cognitive, emotional, and neurobiological factors in AN. However, the precise underlying cognitive and neural mechanisms of these disturbances remain a compelling area of investigation...
2024: PloS One
https://read.qxmd.com/read/38547185/perceptions-of-3r-implementation-in-european-animal-research-a-systematic-review-meta-analysis-and-meta-synthesis-of-barriers-and-facilitators
#18
JOURNAL ARTICLE
Edwin Louis-Maerten, Aoife Milford, David M Shaw, Lester D Geneviève, Bernice S Elger
OBJECTIVES: The purpose of this systematic review was to examine how the scientific community in Europe that is involved with research with animals perceives and experiences the implementation of 3R (Replace, Reduce, Refine). METHODS: A systematic search of the literature published in the past ten years was performed in PubMed, Web of Science and Scopus. Publications were screened for eligibility using a priori inclusion criteria, and only empirical evidence (quantitative, qualitative, or mixed methodologies) was retained...
2024: PloS One
https://read.qxmd.com/read/38547182/a-duo-theme-cloud-model-dematel-approach-for-exploring-the-cause-factors-of-green-supply-chain-management
#19
JOURNAL ARTICLE
Jih-Kuang Chen, Tseng-Chan Tseng
PURPOSE: Decision-Making Trial and Evaluation Laboratory (DEMATEL) methods identify cause factors in green supply chain management (GSCM). This study argues that the target method treats affecting factors as unique themes; however, various factors may be mutually antagonistic (i.e., mutually positive or negative) or encompass other meaningful information (e.g., gain/risk, intensify/depress). The factor affecting GSCM implicitly encompasses the economy and ecology (greenness), which may conflict...
2024: PloS One
https://read.qxmd.com/read/38547173/a-deep-learning-approach-for-named-entity-recognition-in-urdu-language
#20
JOURNAL ARTICLE
Rimsha Anam, Muhammad Waqas Anwar, Muhammad Hasan Jamal, Usama Ijaz Bajwa, Isabel de la Torre Diez, Eduardo Silva Alvarado, Emmanuel Soriano Flores, Imran Ashraf
Named Entity Recognition (NER) is a natural language processing task that has been widely explored for different languages in the recent decade but is still an under-researched area for the Urdu language due to its rich morphology and language complexities. Existing state-of-the-art studies on Urdu NER use various deep-learning approaches through automatic feature selection using word embeddings. This paper presents a deep learning approach for Urdu NER that harnesses FastText and Floret word embeddings to capture the contextual information of words by considering the surrounding context of words for improved feature extraction...
2024: PloS One
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