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https://www.readbyqxmd.com/read/29142086/shortage-of-generic-neurologic-therapeutics-an-escalating-threat-to-patient-care
#1
Jacklyn O Omorodion, Rami M Algahtani, Mark S Zocchi, Erin R Fox, Jesse M Pines, Henry J Kaminski
OBJECTIVE: To assess longitudinal trends in shortages of generic drugs used for neurologic conditions over a 15-year period in the United States. METHODS: Drug shortage data from the University of Utah Drug Information Service (UUDIS) from 2001 to 2015 were analyzed. Medications were included that were likely to be prescribed by a neurologist to treat a primary neurologic condition or critical for care of a patient with a neurologic condition. Trends in shortage length were assessed using standard descriptive statistics...
November 15, 2017: Neurology
https://www.readbyqxmd.com/read/29129980/quality-of-care-of-patients-with-diabetes-in-primary-health-services-in-southeast-brazil
#2
Christiane Chaves Augusto Leite Simão, Mônica Barros Costa, Fernando Antônio Basile Colugnati, Elaine Amaral de Paula, Chislene Pereira Vanelli, Rogério Baumgratz de Paula
Background: Diabetes management involves multiple aspects that go beyond drug therapy as a way of providing high quality care. The objective of this study was to describe quality of care indicators for individuals with diabetes in southeast Brazil and to explore associations among these indicators. Methods: In this cross-sectional, observational study, health care providers filled out a questionnaire addressing health care structure and processes at 14 primary health care units (PHCUs)...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/29094099/improving-access-to-cancer-treatments-the-role-of-biosimilars
#3
Rakesh Chopra, Gilberto Lopes
Biologics play a key role in cancer treatment and are principal components of many therapeutic regimens. However, they require complex manufacturing processes, resulting in high cost and occasional shortages in supply. The cost of biologics limits accessibility of cancer treatment for many patients. Effective and affordable cancer therapies are needed globally, more so in developing countries, where health care resources can be limited. Biosimilars, which have biologic activity comparable to their corresponding reference drugs and are often more cost effective, have the potential to enhance treatment accessibility for patients and provide alternatives for decision makers (ie, prescribers, regulators, payers, policymakers, and drug developers)...
October 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29078760/in-silico-repurposing-of-antipsychotic-drugs-for-alzheimer-s-disease
#4
Shivani Kumar, Suman Chowdhury, Suresh Kumar
BACKGROUND: Alzheimer's disease (AD) is the most prevalent form of dementia and represents one of the highest unmet requirements in medicine today. There is shortage of novel molecules entering into market because of poor pharmacokinetic properties and safety issues. Drug repurposing offers an opportunity to reinvigorate the slowing drug discovery process by finding new uses for existing drugs. The major advantage of the drug repurposing approach is that the safety issues are already investigated in the clinical trials and the drugs are commercially available in the marketplace...
October 27, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/29061442/a-novel-glycoprotein-d-specific-monoclonal-antibody-neutralizes-herpes-simplex-virus
#5
Ruikun Du, Lili Wang, Hao Xu, Zhiying Wang, Tao Zhang, Manli Wang, Yunjia Ning, Fei Deng, Zhihong Hu, Hualin Wang, Yi Li
The worldwide prevalence of herpes simplex virus (HSV) and the shortage of efficient vaccines and novel therapeutic strategies against HSV are widely global concerns. The abundance on the virion and the major stimulus for the virus-neutralizing antibodies makes gD a predominant candidate for cure of HSV infection. In this study, we generated a monoclonal antibody (mAb), termed m27f, targeting to glycoprotein D (gD) of HSV-2, which also has cross-reactivity against HSV-1 gD. It has a high level of neutralizing activity against both HSV-1 and HSV-2, and binds to a highly conserved region (residues 292-297) within the pro-fusion domain of gD...
October 20, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29033595/drug-tendering-drug-supply-and-shortage-implications-for-the-uptake-of-biosimilars
#6
REVIEW
George Dranitsaris, Ira Jacobs, Carol Kirchhoff, Robert Popovian, Lesley G Shane
Due to the continued increase in global spending on health care, payers have introduced a number of programs, policies, and agreements on pharmaceutical pricing in order to control costs. While incentives to increase generic drug use have achieved significant savings, other cost-containment measures are required. Tendering is a formal procedure to purchase medications using competitive bidding for a particular contract. Although useful for cost containment, tendering can lead to decreased competition in a given market...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29030411/global-shortage-of-neonatal-and-paediatric-antibiotic-trials-rapid-review
#7
Georgina Thompson, Charlotte I Barker, Laura Folgori, Julia A Bielicki, John S Bradley, Irja Lutsar, Mike Sharland
OBJECTIVES: There have been few clinical trials (CTs) on antibiotics that inform neonatal and paediatric drug labelling. The rate of unlicensed and off-label prescribing in paediatrics remains high. It is unclear whether the current neonatal and paediatric antibiotic research pipeline is adequate to inform optimal drug dosing. Using the ClinicalTrials.gov registry, this review aims to establish the current global status of antibiotic CTs in children up to 18 years of age. METHODS: Studies were identified using key word searches of the ClinicalTrials...
October 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/29029637/drug-resistance-patterns-following-pharmacy-stock-shortage-in-nigerian-antiretroviral-treatment-program
#8
Seema T Meloni, Beth Chaplin, John Idoko, Oche Agbaji, Sulaimon Akanmu, Godwin Imade, Prosper Okonkwo, Robert L Murphy, Phyllis J Kanki
BACKGROUND: For patients on antiretroviral therapy (ART), treatment interruptions can impact patient outcomes and result in the accumulation of drug resistance mutations leading to virologic failure. There are minimal published data on the impact of an ART stock shortage on development of drug resistance mutations (DRMs). In this report, we evaluate data from patients enrolled in the Government of Nigeria National ART Program that were receiving treatment at the time of a national drug shortage in late 2003...
October 13, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/29029067/pharmacodynamics-of-fosfomycin-against-esbl-and-or-carbapenemase-producing-enterobacteriaceae
#9
Fiona Fransen, Kelly Hermans, Maria J B Melchers, Claudia C M Lagarde, Joseph Meletiadis, Johan W Mouton
Background: The increase in antibiotic resistance in Gram-negative bacteria and the limited therapeutic options due to the shortage of new antibiotics have increased the interest of the 'old' antibiotic fosfomycin in the treatment of infections. However, there are contradictory reports on the pharmacodynamics of and emergence of resistance to fosfomycin. Methods: Time-kill assays were performed with 11 ESBL-positive and 3 ESBL-negative strains, exposing the bacteria to 2-fold static concentrations from 0...
October 4, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28988252/drug-shortages-in-large-hospitals-in-riyadh-a-cross-sectional-study
#10
Yazed Sulaiman AlRuthia, Hadeel AlKofide, Refaa'h AlAjmi, Bander Balkhi, Ahmed Alghamdi, Albandari AlNasser, Areej Alayed, Maali Alshammari, Danah Alsuhaibani, Asma Alathbah
BACKGROUND: Drug shortages are a serious and complex issue in any healthcare system. We conducted this study because the prevalence of drug shortages in Saudi Arabia is largely unknown, while there have been reports of shortages. OBJECTIVE: To explore the prevalence and characteristics of drug shortages as well as identify strategies to minimize their impact on patient care and safety in large hospitals. DESIGN: Questionnaire-based cross-sectional study...
September 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28981138/greece-crisis-smoking-and-tobacco-conflicts-in-social-media
#11
John P A Ioannidis
Greece has undergone a distressing crisis that has taken a heavy toll, devaluing lives of individuals and functions of society at large. Besides the economic meltdown, there has been an even worse crisis of values. The country currently occupies a low rank in the WHO Happiness Index (1) (99(th) in 2016 and 87(th) in 2017), not so much because of worsening ranking in healthy life expectancy (still ranked 24(th) in the world in 2017) or even wealth (still ranked 44(th) in GDP per capita), but because of mediocre ranking in social support (ranked 80(th) ) and extremely low rankings in freedom to make life choices (ranked 150(th) among 155 countries), generosity (ranked 155(th) , i...
October 5, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28970246/u-s-vaccine-and-immune-globulin-product-shortages-2001-15
#12
Victoria C Ziesenitz, Maryann Mazer-Amirshahi, Mark S Zocchi, Erin R Fox, Larissa S May
PURPOSE: Trends in shortages of vaccines and immune globulin products from 2001 through 2015 in the United States are described. METHODS: Drug shortage data from January 2001 through December 2015 were obtained from the University of Utah Drug Information Service. Shortage data for vaccines and immune globulins were analyzed, focusing on the type of product, reason for shortage, shortage duration, shortages requiring vaccine deferral, and whether the drug was a single-source product...
October 2, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28966259/phylogenic-analysis-and-evaluation-of-ephedra-plants-and-aconites-for-medicinal-use
#13
Nobuko Kakiuchi
Although Kampo medicine is now fully integrated into the modern Japanese healthcare system, most Kampo formulations depend on imported crude drugs from limited foreign areas. To prepare for possible shortages of crude drugs in the future, a wider scope for the supply of medicinal plants is necessary. We conducted field research and collaborated with international laboratories for phylogenic analysis and evaluation of medicinal plant resources. Our research on ephedra plants from a wide region of Eurasia has, for example, confirmed their phylogenic structure: based on DNA sequencing analysis of nuclear ribosomal internal transcribed spacer region 1 (ITS1) as well as the chloroplast intergenic spacer between trnL and trnF (trnL-F), the 8 major Chinese species and related plants grown on the continent could be divided into 3 groups...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28960622/the-experiences-of-being-a-registered-nurse-prescriber-within-an-acute-service-setting
#14
Roisin Lennon, Anne Fallon
AIMS AND OBJECTIVES: This study aimed to explore the experiences of nurse prescribers in an acute services setting. DESIGN: A descriptive phenomenological design underpinned by Husserl's philosophy was used as the guiding framework. Only one UK study had previously explored how nurse prescribers perceived their prescribing practice. METHODS: Data was collected using semi structured interviews and purposive sampling of 11 current Registered Nurse Prescribers (RNP) from 2 acute hospitals...
September 27, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28949838/the-interactions-of-canadian-ethics-consultants-with-health-care-managers-and-governing-boards-during-times-of-crisis
#15
Chris Kaposy, Victor Maddalena, Fern Brunger, Daryl Pullman, Richard Singleton
BACKGROUND: Health care organizations can be very complex, and are often the setting for crisis situations. In recent years, Canadian health care organizations have faced large-scale systemic medical errors, a nation-wide generic injectable drug shortage, iatrogenic infectious disease outbreaks, and myriad other crises. These situations often have an ethical component that ethics consultants may be able to address. Organizational leaders such as health care managers and governing boards have responsibilities to oversee and direct the response to crisis situations...
April 2017: AJOB Empirical Bioethics
https://www.readbyqxmd.com/read/28946918/a-model-for-a-drug-distribution-system-in-remote-australia-as-a-social-determinant-of-health-using-event-structure-analysis
#16
John P Rovers, Michelle D Mages
BACKGROUND: The social determinants of health include the health systems under which people live and utilize health services. One social determinant, for which pharmacists are responsible, is designing drug distribution systems that ensure patients have safe and convenient access to medications. This is critical for settings with poor access to health care. Rural and remote Australia is one example of a setting where the pharmacy profession, schools of pharmacy, and regulatory agencies require pharmacists to assure medication access...
September 25, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28945476/assessment-of-lungs-for-transplant-recovered-from-uncontrolled-donation-after-circulatory-determination-of-death-donors
#17
Thomas Egan, John Blackwell, Katherine Birchard, Benjamin Haithcock, Jason Long, Stephen Gazda, Nissa Casey, Caitlin Thys
RATIONALE: To address the lung donor shortage, we obtained institutional review board and US Food and Drug Administration approval to transplant lungs recovered from uncontrolled donation after circulatory determination of death donors (uDCDDs). OBJECTIVES: To compare outcomes of recipients of lungs recovered from uDCDDs vs. brain-dead donors. METHODS: After consent and screening, lungs recovered from uDCDDs were assessed by 4 hours ex vivo lung perfusion (EVLP) and computed tomography (CT) scan...
September 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28944731/the-fda-unapproved-drugs-initiative-an-observational-study-of-the-consequences-for-drug-prices-and-shortages-in-the-united-states
#18
Ravi Gupta, Sanket S Dhruva, Erin R Fox, Joseph S Ross
BACKGROUND: Hundreds of drug products are currently marketed in the United States without approval from the FDA. The 2006 Unapproved Drugs Initiative (UDI) requires manufacturers to remove these drug products from the market or obtain FDA approval by demonstrating evidence of safety and efficacy. Once the FDA acts against an unapproved drug, fewer manufacturers remain in the market, potentially enabling drug price increases and greater susceptibility to drug shortages. There is a need for systematic study of the UDI's effect on prices and shortages of all targeted drugs...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28934403/improving-inpatient-medication-adherence-using-attendant-education-in-a-tertiary-care-hospital-in-uganda
#19
Patricia Alupo, Richard Ssekitoleko, Tracy Rabin, Robert Kalyesubula, Ivan Kimuli, Benjamin E Bodnar
Quality problem: Although widely utilized in resource-rich health care systems, the use of quality improvement (QI) techniques is less common in resource-limited environments. Uganda is a resource-limited country in Sub-Saharan Africa that faces many challenges with health care delivery. These challenges include understaffing, inconsistent drug availability and inefficient systems that limit the provision of clinical care. Initial assessment: Poor adherence to prescribed inpatient medications was identified as a key shortcoming of clinical care on the internal medicine wards of Mulago National Referral Hospital, Kampala, Uganda...
August 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28933080/-recent-advances-in-biosynthetic-pathway-and-synthetic-biology-of-taxol
#20
Xue-Jun Kuang, Cai-Xia Wang, Li-Qiu Zou, Ying Li, Chao Sun
Taxol, a kind of terpenoid secondary metabolite produced by Taxus brevifolia, is an effective anticancer drug that manufacture relies mainly on the extraction form plants. In order to solve the resource shortage, a lot of work has been done to develop the alternative method. Recently, using synthetic biology to realize heterologous biosynthesis of the precursors of taxol has become a hotspot. Now, the basic framework of taxol biosynthetic pathways has been confirmed, and most enzyme genes involved in taxol biosynthesis have been cloned and identified...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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