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https://www.readbyqxmd.com/read/28646523/does-clinical-placement-in-a-community-alcohol-and-other-drugs-rehabilitation-centre-influence-students-career-intention
#1
Yenna Salamonson, Lucie M Ramjan, Amy R Villarosa, Brahm Marjadi
Due to an ageing workforce, there is a growing need for greater numbers of nurses to work in areas, such as mental health and alcohol and other drugs (AOD) rehabilitation. These practitioners need to approach their work as 'recovery-oriented practitioners'. Positive experiences and preceptorship during clinical placement in AOD rehabilitation settings might influence students' later career choices and address some of the workforce shortage issues. The aim of the present concurrent, mixed-methods study was to explore students' perceptions of their clinical placement experience in a community-based AOD rehabilitation setting, and to examine attitude, career intention, and satisfaction with the placement...
June 23, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/28644271/norepinephrine-shortage-led-to-increased-deaths-from-septic-shock
#2
Serena Stockwell
Though drug shortages are common, their impact is rarely studied.
July 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28622641/u-s-drug-shortages-for-medications-used-in-adult-critical-care-2001-2016
#3
Maryann Mazer-Amirshahi, Munish Goyal, Suleman A Umar, Erin R Fox, Mark Zocchi, Kristy L Hawley, Jesse M Pines
PURPOSE: We describe trends in U.S. shortages impacting critical care drugs from 2001 to 2016. MATERIALS AND METHODS: Shortages within the scope of critical care were identified using data from the University of Utah Drug Information Services. Shortage characteristics were described using standard descriptive statistics and regression analysis. RESULTS: Of 1969 shortages reported, 1004 (51%) were for drugs used in critical care. New shortages fell from 2001 to 2004, then increased, peaking in 2011 (116)...
June 9, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28619448/the-future-of-pharmaceutical-quality-and-the-path-to-get-there
#4
Lawrence X Yu, Michael Kopcha
While six sigma quality has long been achieved in other industries, it is rarely seen in the pharmaceutical sector. However, consumers and patients deserve six sigma quality pharmaceuticals with minimal risks of shortages or recalls. We propose that the future of pharmaceutical quality is six sigma, meaning that no more than 3.4 defects occur per million opportunities. We discuss the path to get there, including economic drivers, performance-based regulation, Quality by Design, advanced manufacturing technologies, and continuous improvement and operational excellence...
June 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28616498/xenotransplantation-a-special-case-of-one-health
#5
REVIEW
Joachim Denner
The chronic shortage of human transplants to treat tissue and organ failure has led to the development of xenotransplantation, the transplantation of cells, tissues and organs from another species to human recipients. For a number of reasons, pigs are best suited as donor animals. Successful, routine xenotransplantation would have an enormous impact on the health of the human population, including the young, who sometimes require a replacement organ or islet cells, but especially the elderly, who more often suffer the consequences of organ failure...
June 2017: One Health
https://www.readbyqxmd.com/read/28604328/the-status-of-vaccine-availability-and-associated-factors-in-tshwane-government-clinics
#6
Ntombenhle Judith Ngcobo, Mercy G Kamupira
BACKGROUND: Vaccines have greatly contributed to the control of vaccine-preventable diseases and to human development. Efforts by many countries to introduce new vaccines are a significant move towards achieving the sustainable development goal for health. However, effective vaccine supply chains that ensure an uninterrupted supply of vaccines are pivotal to attaining universal access to life-saving vaccines and sustainable development. The introduction of new vaccines puts a strain on supply chains; South Africa (SA) is no exception, as there are indications of vaccine stock-outs in clinics...
May 24, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28597416/phytochemical-studies-for-quantitative-estimation-of-iridoid-glycosides-in-picrorhiza-kurroa-royle
#7
Phalisteen Sultan, Arif Jan, Qazi Pervaiz
BACKGROUND: Picrorhiza kurroa Royle commonly known as 'Kutki or Kutaki' is an important medicinal plant in Ayurvedic system of medicine and has traditionally been used to treat disorders of the liver and upper respiratory tract. The plant is the principle source of iridoid glycosides, picrosides I, II and kutkoside used in various herbal drug formulations mainly as strong hepatoprotective and immune-modulatory compound. The species has become endangered to near extinction due to the unregulated collection from the wild, slower plant growth and ecological destruction of natural habitats...
December 2016: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/28594232/revisiting-the-aids-epidemic-in-pakistan-where-we-stand-and-what-we-must-aim-for
#8
Hamza Arshad Dar, Areeba Mubashir, Manal Adil, Aiman Farzeen, Hasaan Naseer, Gohar Ayub, Sajid Mansoor, Aneela Javed
Human Immunodeficiency type 1 (HIV-1) is the major cause of Acquired Immunodeficiency Syndrome (AIDS) in humans, where the immune system totally succumbs to the virus. Large proportion of the AIDS infected belong to developing countries and AIDS prevalence is intensified by severe poverty, malnutrition and famine; fatal illnesses with a scorn shortage of medical amenities complemented with the lack of education and development. Current Pakistani health system setting is in a dire need of improvement. Low literacy rates, high birth rates and associated maternal mortality plus a lack of clean drinking water and appropriate sanitation system have a serious impact on general living conditions contributing to a relatively short life-span...
June 8, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28591207/long-term-growth-comparison-studies-of-fbs-and-fbs-alternatives-in-six-head-and-neck-cell-lines
#9
Chih-Yeu Fang, Chung-Chun Wu, Chia-Lang Fang, Wei-Yu Chen, Chi-Long Chen
Fetal bovine serum (FBS) is depended upon by investigators as an indispensable supplement in cell and tissue culture systems. Due to increased demand and limited availability, the price of FBS has increased by greater than 300% in the past few years. In addition, there are ethical and scientific controversies about the collection and use of FBS in culture systems. In response to the shortage of FBS, many FBS alternative serum products have been developed. Although many have claimed comparable performance to FBS, their support of long-term cell growth and effects on cell phenotype have not been revealed...
2017: PloS One
https://www.readbyqxmd.com/read/28553023/process-evaluation-of-communitisation-programme-in-public-sector-health-facilities-mokokchung-district-nagaland-2015
#10
Aonungdok Tushi, Prabhdeep Kaur
BACKGROUND: Public sector health facilities were poorly managed due to a history of conflict in Nagaland, India. Government of Nagaland introduced "Nagaland Communitisation of Public Institutions and Services Act" in 2002. Main objectives of the evaluation were to review the functioning of Health Center Managing Committees (HCMCs), deliver health services in the institutions managed by HCMC, identify strengths as well as challenges perceived by HCMC members in the rural areas of Mokokchung district, Nagaland...
April 2017: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/28545614/-hera-quest-hta-evaluation-of-generic-pharmaceutical-products-to-improve-quality-economic-efficiency-patient-safety-and-transparency-in-drug-product-changes-in-hospitals
#11
Miriam Gyalrong-Steur, Anita Kellermann, Rudolf Bernard, Georg Berndt, Meike Bindemann, Elfriede Nusser-Rothermundt, Steffen Amann, Myga Brakebusch, Jörg Brüggmann, Eva Tydecks, Markus Müller, Frank Dörje, Eberhard Kochs, Rainer Riedel
In view of the rising cost pressure and an increasing number of drug shortages, switches between generic drug preparations have become a daily routine in hospitals. To ensure consistently high treatment quality and best possible patient safety, the equivalence of the new and the previous drug preparation must be ensured before any change in the purchase of pharmaceutical products takes place. So far, no easily usable, transparent and standardized instrument for this kind of comparison between generic drug products has been available...
April 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28541542/reducing-stock-outs-of-essential-tuberculosis-medicines-a-system-dynamics-modelling-approach-to-supply-chain-management
#12
L Bam, Z M McLaren, E Coetzee, K H von Leipzig
The under-performance of supply chains presents a significant hindrance to disease control in developing countries. Stock-outs of essential medicines lead to treatment interruption which can force changes in patient drug regimens, drive drug resistance and increase mortality. This study is one of few to quantitatively evaluate the effectiveness of supply chain policies in reducing shortages and costs. This study develops a systems dynamics simulation model of the downstream supply chain for amikacin, a second-line tuberculosis drug using 10 years of South African data...
May 24, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28537981/development-of-education-and-research-in-anesthesia-and-intensive-care-medicine-at-the-university-teaching-hospital-in-lusaka-zambia-a-descriptive-observational-study
#13
Anna Janowicz, Tuma Kasole, Emily Measures, Meg Langley, Fastone M Goma, Feruza Ismailova, John A Kinnear, M Dylan Bould
BACKGROUND: Data from 2006 show that the practice of anesthesia at the University Teaching Hospital in Lusaka, Zambia was underdeveloped by international standards. Not only was there inadequate provision of resources related to environment, equipment, and drugs, but also a severe shortage of staff, with no local capability to train future physician anesthetic providers. There was also no research base on which to develop the specialty. This study aimed to evaluate patient care, education and research to determine whether conditions had changed a decade later...
July 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28535898/treatment-of-postmenopausal-osteoporosis-a-literature-based-algorithm-for-use-in-the-public-health-care-system
#14
Ellen Luz Pereira Caires, Mailze Campos Bezerra, Ana Flávia Torquato de Araújo Junqueira, Sheila Márcia de Araújo Fontenele, Silvana Cristina de Albuquerque Andrade, Catarina Brasil d'Alva
Bisphosphonates are considered first-line agents in the treatment of postmenopausal osteoporosis based on extensive experience of use, safety, and proven efficacy in reducing vertebral, non-vertebral and femur fractures. However, post-marketing reports based on the treatment of millions of patients/year over lengthy periods of time have revealed the occurrence of initially unexpected adverse effects, such as osteonecrosis of the jaw and atypical femoral fracture, leading to the restriction of treatment duration with bisphosphonates by global regulatory agencies...
May 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28503641/the-role-of-a-nurse-specialist-in-palliative-care-an-israeli-experience
#15
Suzanne Csorba
Given the severe shortage of physicians in Israel, the Ministry of Health issued a decree that offered advanced authority and responsibilities to experienced nurses; thus, the status of the nurse specialist (NS) was created. The role of NS in Israel is truly varied, incorporating many different facets that range from stabilizing to changing the existing palliative care (PC) orders, including those involving dosages and methods of care provision, issuing of repeat prescriptions, suspending drug treatment, and prescribing new drugs for a patient according to a protocol issued by a physician...
April 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28496968/resolving-shortages-of-prescription-drugs-the-case-for-public-private-collaboration
#16
Eric Efraim Katz
The recent IJHPR article by Schwartzberg and colleagues presents new data on the growing problem of prescription drug shortages. Resolving shortages typically involves many participants: government, industry, physicians and healthcare facilities. Israel has a strong record of informal collaboration that can fix drug shortages quickly. The success of Israel's informal collaborations, as well as its formal partnerships, deserves broader recognition at home and more attention from the international community.
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28492457/the-role-of-amantadine-withdrawal-in-3-cases-of-treatment-refractory-altered-mental-status
#17
Leah D Fryml, Kristen R Williams, Christopher G Pelic, James Fox, Gregory Sahlem, Sophie Robert, Gonzalo J Revuelta, Edward Baron Short
Amantadine, which was originally developed as an antiviral medication, functions as a dopamine agonist in the central nervous system and consequently is utilized in the treatment of Parkinson disease, drug-induced extrapyramidal reactions, and neuroleptic malignant syndrome. For reasons that are not entirely understood, abrupt changes in amantadine dosage can produce a severe withdrawal syndrome. Existing medical literature describes case reports of amantadine withdrawal leading to delirium, which at times has progressed to neuroleptic malignant syndrome...
May 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28473448/india-and-the-coronary-stent-market-getting-the-price-right
#18
Priya Wadhera, Thomas Alexander, Brahmajee K Nallamothu
On February 13, 2017, India's National Pharmaceutical and Pricing Authority (NPPA) made a landmark decision to fix price ceilings for coronary stents at 7260 rupees for bare metal stents and 29 600 rupees for drug-eluting stents (US equivalents of $108 and $444, respectively).(1,2) Stents had been placed on the National List of Essential Medications (NLEM) in July 2016 by the health ministry.(1) In India, stents turned out to be subject to substantial price markups on their journey from manufacturer to patient, at times exceeding 4 times their original imported value...
May 4, 2017: Circulation
https://www.readbyqxmd.com/read/28472025/addressing-a-yellow-fever-vaccine-shortage-united-states-2016-2017
#19
Mark D Gershman, Kristina M Angelo, Julian Ritchey, David P Greenberg, Riyadh D Muhammad, Gary Brunette, Martin S Cetron, Mark J Sotir
Recent manufacturing problems resulted in a shortage of the only U.S.-licensed yellow fever vaccine. This shortage is expected to lead to a complete depletion of yellow fever vaccine available for the immunization of U.S. travelers by mid-2017. CDC, the Food and Drug Administration (FDA), and Sanofi Pasteur are collaborating to ensure a continuous yellow fever vaccine supply in the United States. As part of this collaboration, Sanofi Pasteur submitted an expanded access investigational new drug (eIND) application to FDA in September 2016 to allow for the importation and use of an alternative yellow fever vaccine manufactured by Sanofi Pasteur France, with safety and efficacy comparable to the U...
May 5, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28454539/workplace-violence-against-nurses-in-the-gambia-mixed-methods-design
#20
Ebrima J Sisawo, Saide Yacine Y Arsène Ouédraogo, Song-Lih Huang
BACKGROUND: The aim of this study was to assess the prevalence, perpetrators and factors associated with workplace violence against nurses in public secondary health care facilities from two health regions in the Gambia. METHODS: Data was collected from 219 nurses using self-administered questionnaire and 35 face-to-face interviews. The data collection was conducted between July and September 2014 in 14 public secondary health care facilities. RESULTS: A sizable majority of respondents (62...
April 28, 2017: BMC Health Services Research
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